NEURO-­‐CELLULITE  TREATMENT  

STRESS = the bane of the century ➥ It upsets: ✓ our behavior ✓ the body metabolism. It causes skin reactions:

◆ Overreacting skin, ◆ Nerve blockage, ◆ High blood pressure, ◆ Poor elimination, ◆ General or localized fat storage.

LIPO-STRESS NEURO-LIPOLYSIS STIMULATION

New scientific technology: ➥ demonstrates interactions between

the nervous system and the skin through neurotransmitters.

Neurotransmitters: ◆ Regulate messages sent from the brain, ◆  Relay nerve impulse. Neuro-cosmetics is the perfect partner for neuro-aesthetics techniques, such as: ✓ Acupuncture ✓ Acupressure ➥ Increase of β-endorphins, pain-killer

molecules.

NEURO-COSMETICS

LIPO-STRESS NEURO-LIPOLYSIS STIMULATION

A new generation slimming treatment. A DUAL ACTION ● In skin upper layers  ✓ Increases the production of β-endorphins → Releases tensions → Eases elimination of fat deposits ● In skin deeper layers   ✓Improves the innervation of adipose tissue → Relieves congestion of adipocytes LIPO-STRESS ACTIONS: ◆ Relieves painful localized cellulite

◆ Decreases stress in body prone to fat retention.

 IN THE UPPER LAYERS OF THE SKIN

● Due to the release of neurotransmitters, the skin nervous system controls: ✓ Cell proliferation and differentiation:

keratinocytes, adipocytes ✓ Production of neurotransmitters ✓ Activation of immune cells.

➡ BUT stress upsets the fragile balance

of the skin neuromodulators: ➪ Eases fat storage ➪ Limits fat release.

RELATIONSHIP BETWEEN SKIN STRESS AND CELLULITE

• Endorphins: specific neurotransmitters produced by nerve endings and keratinocytes. ➔ ANTI-STRESS, pain-killer effect, feeling of well-being. • Due to relaxation:

✓ Lipogenesis resulting from stress decreases ✓ Lipolysis is triggered.

➠ Cellulite is reduced ➠ Orange peel skin is improved.

• You feel better about yourself ➔ the downward spiral generated by stress is

discontinued.

SOLUTION: ENDORPHINS TO FEND OFF STRESS

BETAPHROLINE: new patented neurocosmetic active ingredient of plant origin.

NEUROCOSMETICS: RELEASE OF β-ENDORPHINS

• Tephrosia purpurea extract: plant native to the tropical regions of India, Africa and Sth America. • BETAPHROLINE stimulates the release of ß-endorphins by keratinoyctes.  

STIMULATION OF THE RELEASE OF ß-ENDORPHINS BY KERATINOCYTES

Test carried out on a culture of human keratinocytes incubated for 24 hours.

BETAPHROLINE IN VITRO TEST

+163% Increase of β-endorphins

➥ANTI-STRESS

ACTION

• Numerous enzymatic reactions occur within adipocytes resulting in: ➔ either lipogenesis ➔ or lipolysis.

BETAPHROLINE: STIMULATION OF LIPOLYSIS

• In vitro tests demonstrate the efficacy of BETAPHROLINE: ➠ To stimulate lipolysis ➠ To reduce lipogenesis.

• Lipolysis requires a particular messenger: cyclic AMP, (cAMP) Adenosine Mono Phosphate derived from ATP. cAMP is stimulated by an enzyme: adenylyl cyclase.

BETAPHROLINE: STIMULATION OF cAMP

+ 85 %

Activation of

ADENYLYL CYCLASE

➥ Increase in lipolysis

 

• Lipogenesis is activated in adipocytes by the enzyme Glycerol-3-Phosphate Di-Hydrogenase or G3PDH ➠ Storage of carbs into triglycerides.

BETAPHROLINE: INHIBITION OF LIPOGENESIS

INHIBITION of G3PDH

due to BETAPHROLINE:

-  60 % ➥ Decrease in

Lipogenesis ➥ Activation

of lipolysis

• AQ-PRESS: ACUPRESSURE device using VIBRATIONS ➠ Release of ß-endorphins. • AQ-PRESS provides: ✓ a thorough body relaxation ✓ a relief of tensions.

AQ-PRESS RELIEVES TENSION POINTS AND STIMULATES β-ENDORPHINS

➠ EASES THE SLIMMING PROCESS.  

• Combined with the LIPO-STRESS treatment protocol:

• AQ-PRESS: ACUPRESSURE of ACUPUNCTURE

points on the body: ➔ Restores energy flow ➔ Strengthens body metabolism ➔ Improves well-being.

AQ-PRESS RELIEVES TENSION POINTS AND STIMULATES β-ENDORPHINS

ACTION IN THE UPPER SKIN LAYERS  ON THE

DEEPER LAYERS OF THE SKIN  

A neuron has a cell body with profusely branching extensions extruding from it. ✓ Dendrites →

receive and convey messages or nerve impulse coming from other nerve cells, to the cell body of the neuron.

NERVOUS SYSTEM: NEURON

✓ The axon → transmits signals (nerve impulse) to the other cells of the body.

The transmission of nerve impulse takes place through different neurotransmitters.

Skin nerves answer to stimuli coming from: • Blood circulation • Emotional stress. Due to the production of chemical modulators, they can process information within the skin regarding:  

THE DEEP CUTANEOUS NERVOUS SYSTEM

✓ Vasomotion, ✓ Thermoregulation, ✓ Secretion of glands

and cells such as fibroblasts, adipocytes ✓ Tissue growth and

differentiation.

THE DEEP CUTANEOUS NERVOUS SYSTEM

• In the skin, neuromodulators such as endorphins are produced by: ✓ Skin nerve fibers, ✓ Keratinocytes, ✓ Fibroblasts.

• Keratinocytes, fibroblasts and adipocytes CAN also synthesize: → growth factors.

• Specific proteins that: ✓Participate in the

proliferation of different cell types

✓Exert numerous functions in the development of the body.

• Rita Levi-Montalcini won the Nobel Prize in Medicine

in 1986 for the discovery of the Nerve Growth Factor, NGF.

• NGF: the 1st growth factor that has been discovered. • Since then, various growth factors have been

identified: the epidermal growth factor (EGF), the fibroblast growth factor (FGF), etc.

SKIN GROWTH FACTORS

• NGF: ✓Facilitate the growth of nerve extensions ✓ Keep neuron alive ✓ Work on ADIPOCYTE functioning.

⚠ They are produced in limited quantities.

➤ COMPETITION BETWEEN NEURONS ➥ Neurons without NGF stimulation disappear by

apoptosis or process of programmed cell death.  

NGF: NERVE GROWTH FACTOR

• Development of cellulite: ✓ Hypertrophy of adipocytes ✓ Disruption:

◆ of innervation ◆ of blood and lymph circulation. • Cell aging ➥ Causes a decrease of NGF synthesis. ➥ Hinders communication between cells.

GROWTH FACTOR AND CELLULITE

NEW PATHWAY IN THE FIGHT AGAINST CELLULITE

GROWTH FACTOR AND CELLULITE

Protecting neurons by NGF helps: ◆ Stimulate lipolysis ◆ Reduce lipogenesis

◆ Prevent tissue hypoxia and oxidative stress, ➤ which triggers fat storage.

Statement in laboratory: • Optimum innervation of the adipose tissue, • The more NGF, ⇒ the easier the lipolysis process.

GROWTH FACTOR AND CELLULITE

RESULTS: ⇒ The NGF is in direct contact with adipocytes: no effect on lipolysis ⇒ Low innervation of the adipose tissue with the NGF triggers a slight increase in lipolysis: + 32% ⇒ Optimal innervation of the adipose tissue with the NGF triggers a significant increase in lipolysis: +117%

GROWTH FACTOR AND CELLULITE

OPTIMUM INNERVATION RESULTS IN OPTIMAL LIPOLYSIS  

Our research laboratories have developed a new active ingredient for NEUROPROTECTION: GLUTRAPEPTIDE derived from biotechnology.   GLUTRAPEPTIDE: NGF-LIKE

➤ Activates innervation of adipose tissue ➤ Potentializes the neuron answer to the NGF ➤ Protects deep nerve endings ➤ Stimulates optimum lipolysis by acting on the length of nerve fibers (neurite).

GLUTRAPEPTIDE: NEUROPROTECTION & NEUROLIPOLYSIS

GLUTRAPEPTIDE helps reach optimal innervation characterized by an average length of neurite of more than 20%  

Acting on neurons, GLUTRAPEPTIDE increases: ➤ Their survival rate ➤ Their metabolic activity ➤ Their ability to optimize lipolysis.

GLUTRAPEPTIDE: OPTIMIZATION OF LIPOLYSIS

GLUTRAPEPTIDE increases the release of glycerol by

51%  

IN VIVO TEST: GLUTRAPEPTIDE potentializes the action of the NGF on: ✓ Fibroblast contraction ✓ Collagen fibers ⇒ IMMEDIATE TIGHTENING EFFECT ⇒ LONG TERM EFFECT: FIRMER SKIN WITH MORE TONE

FIRMING EFFECT OF GLUTRAPEPTIDE

GLUTRAPEPTIDE improves skin firmness, elasticity and density after only 28 days  

Increase in lipolysis:

- 4 cm in arm - 6 cm in hip

- 3.5 cm in thigh circumference

LIPO-STRESS, A TREATMENT FOR CELLULITE OF NERVOUS

ORIGIN  

PROFESSIONAL SALON PRODUCTS

HOME CARE PRODUCTS

INDICATION Quickly eliminates dead cells. Activates microcirculation, provides better tissue oxygenation, stimulates the release of β-endorphins.

DIRECTIONS FOR USE Apply all over the body and carry out a message using circular movements. Rinse with hot towels. See our professional protocol.

INGREDIENTS GLUTRAPEPTIDE: stimulates neurolipolysis

BETAPHROLINE: stimulates the release of β-endorphins

ELEUTHERO: toning, rich in vitamins B

WAKAMINE: lightens the skin

PINEAPPLE: draining

GRAPEFRUIT: toning, anti-elastase

PRESENTATION Retail: not available Professional use: 400-ml pot - Ref. E882

LIPO-GUM SLIMMING EXFOLIATION

INDICATION Strengthens skin neuroprotection, stimulates neurolipolysis.

DIRECTIONS FOR USE Apply on cellulite areas. See professional protocol.

INGREDIENTS

GLUTRAPEPTIDE: stimulates neurolipolysis

BETAPHROLINE: stimulates the release of β-endorphins

PALMARIA PALMATA: vein protector, draining

SVELTONYL: inhibits phosphodiesterase, draining

PRESENTATION Retail: not available Professional use: 500-ml bottle Ref. E883

SOLUTION NEUROLYSE

INDICATION Optimal body relaxation, helps the absorption of slimming ingredients due to the warm sensation produced upon application.

DIRECTIONS FOR USE Perform a relaxing massage to tense areas and knead areas with cellulite.

INGREDIENTS GREEN TEA: lipolytic

GUARANA: stimulates lipolysis

MATE: lipolytic

PASSIFLORA: vein protector

PRESENTATION Retail: not available Professional use: 500-ml bottle – Ref. E884

LIPO-MASSAGE ZEOLITHE THERMO-RELAXING ACTION

INGREDIENTS GLUTRAPEPTIDE: stimulates neurolipolysis

BETAPHROLINE: stimulates the release of β-endorphins

- WHITE TEA: lipolytic, anti-inflammatory, antioxidant TAMANU OIL: vein protector

KIMARINE: antioxidant

PRESENTATION Retail: 150-ml bottle - Ref. E879 in box - Ref. E881 Professional use: 200-ml tube - Ref. E885

FLUIDE DESTRESS STRONG SKIN NEUROPROTECTOR

INDICATION Stimulates anti-stress receptors due to the release of β-endorphins.

DIRECTIONS FOR USE Mix DESTRESS FLUID with NEUROLYSIS SERUM in the DESTRESS bottle. Give it a lengthy shake. Apply morning and evening to cellulite areas. See professional protocol.

INDICATION Smoothing effect on unsightly cellulite dimpling. DIRECTIONS FOR USE Mix DESTRESS FLUID with NEUROLYSE SERUM in the DESTRESS bottle. Give it a lengthy shake. Apply morning and evening to cellulite areas. INGREDIENTS PALMARIA PALMATA: vein protector, draining

SVELTONYL: inhibits phosphodiesterase, draining

PRESENTATION Retail: 10-ml bottle - Ref. E880 in box Ref. E881

Professional use: not available

NEUROLYSE SERUM STRONG SKIN NEUROPROTECTOR

SALON TREATMENT PROTOCOL INDICATION

A new-generation slimming treatment Dual action on neuromodulators, on the surface and deep down

Release of relaxing molecules.

DANGER  WARNING!  DO  NOT  USE  THE  ELECTRIC  BLANKET  IN  THIS  TREATMENT  AT  THE  SAME  TIME  AS  THE  ALUMINIUM  FOIL  SHEET.  

NB.  This  treatment  can  be  carried  out  without  a  shower.  

PREPARING THE TREATMENT BED

WITH AN ELECTRIC BLANKET WITHOUT AN ELECTRIC BLANKET

Open out the blanket and cover it with a plastic sheet E07.

Lay a large towel (client comfort)

Lay another plastic sheet E07 folded in half for the scrub

Open out the SLIM EXPRESS ALUMINIUM FOIL E602

Lay a large towel to prevent the skin from sticking to the sheet and

reduce the rustle of the sheet

Lay a plastic sheet E07 folded in half for the scrub

SALON TREATMENT PROTOCOL

EXFOLIATION FRONT / BACK Proceed with a complete scrub of the front of the body with LIPO-GUM E882. Make alternating movements until complete elimination of the product. Shower is not necessary. Proceed with a scrub on the back. Once the scrub is over, remove the plastic sheet.

RELEASING TENSIONS BACK Using one AQ-PRESS E886 device in each hand, position them on the acupuncture points as shown in the diagrams here opposite and press firmly on the handles to make the devices vibrate. Each pressure should last at least 10 seconds. From the feet moving upwards to the shoulders.

SALON TREATMENT PROTOCOL

APPLYING E883 SOLUTION NEUROLYSE BACK Apply on the cellulite areas.

THERMO-RELAXING MASSAGE BACK Carry out a long massage with ZEOLITE LIPO-MASSAGE E884 all over the body. During the massage, add a blob of product regularly to boost the thermo-heating effect. Apply a thick layer of ZEOLITE LIPO-MASSAGE E884. The client turns over. Repeat steps 2, 3 and 4 on the front side.

SALON TREATMENT PROTOCOL BODY WRAP Cover the client with the SLIM EXPRESS E602 aluminium sheet or the PLASTIC SHEET E07 for 20min. Clean the skin with hot towels or a shower.

END OF TREATMENT MASSAGE FRONT / BACK Apply DESTRESS FLUID E885 all over the body.

LENGTH OF TREATMENT = 1HR 15MIN. 8-SESSION TREATMENT

FREQUENCY = TWICE A WEEK

Reminder: you can use an electric blanket instead of the aluminium sheet. Danger warning: Do not use the aluminium SLIM EXPRESS (E602) together with he electric blanket. In this case, replace with a plastic sheet (E07).

LIPO-STRESS : A new-generation slimming treatment A DUAL ACTION

● In the upper skin layers: BETAPHROLINE ✓ Increases the production of β-endorphins → Relieves tensions → Helps the elimination of fat:  stimulation of Adenylyl cyclase by 85%. ● In the deeper skin layers: GLUTRAPEPTIDE ✓Improves innervation of adipose tissue → Relieves congestion of adipocytes LIPOLYSIS GENERATED BY NEURONS IS STIMULATED BY 51% LIPO-STRESS ACTIONS: ◆ Relieve painful localized cellulite

◆ Decrease stress in body prone to fat retention.

LIPO-STRESS NEURO-LIPOLYSE STIMULATION

NEURO-­‐CELLULITE    TREATMENT