cell size regulation in bacteria department of physics, harvard university, cambridge, massachusetts...
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Cell Size Regulation in BacteriaDepartment of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
Ariel Amir
doubling time modelVd=f(Vb) 在時間 τ(Vb) 時,如果 f(Vb)為 constant 則回到 critical size model
constant τd with 2Vb =f(Vb)
• Any two models that agree to lowest order will result in similar distributions We therefore choose to solve an equivalent model that will be amenable to analytic treatment
corresponds
• a=0 → f(Vb) =2Vb ta= τd
doubling time model• a=1 → f(Vb) =2V0
critical size model
• a=1/2
incremental model
• 因為 tn 是 Gaussian variable ,我們發現 也是 Gaussian variable
• 將 的變異數定為 σv2
→∴P(Vb)將是 log-normal distribution
distribution of division times
• vb depends only on the noise ta is independent of tn
• and tn are Gaussian variables
→ the resulting interdivision time is tribution is also Gaussian
distribution of division times• Variance given by
• α → 0 σv diverges
• 只有在 0<a<2 有 stationary distribution
correlation coefficient• the correlation coefficient between
mother size at birth and daughter size at birth is the same as that between size at birth and size at division.
summary1. Cell size depends exponentially on growth rate.2. Cell size distributions are approximately log-
normal.3. The correlation coefficient between size at
birth and division is approximately ½4. The correlation coefficient between size at
birth and time to division is approximately -1/2