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Cell Growth & Differentiation Vol. 10, 545-554, 1999

Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes Gene Amplification

Ruth A. Gjerset, Svetlana Lebedeva, Ali Haghighi, Sally T. Turla and Dan Mercola

Page 3: Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes

Page 4: Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes

(1) MEFs: Mouse Embryonic Fibroblast

Two independent experiment system

(2) A lung tumor cell line derived from mice expressing an oncogenic K-Ras mutation (K-RasG12D)

p53 + or -

DNA damage (Doxorubicin; a drug used in cancer chemotherapy)

p53 + or -

Page 5: Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes

cre-lox recombination system

Cre-Lox recombination involves the targeting of a specific sequence of DNA and splicing it with the help of an enzyme called Cre recombinase.

Page 6: Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes

Page 7: Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes

Page 8: Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes

Page 9: Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes

Page 10: Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes

Page 11: Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes

Page 12: Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes

Page 13: Cell Growth & Differentiation Vol. 10, 545-554, 1999 Inhibition of the Jun Kinase Pathway Blocks DNA Repair, Enhances p53-mediated Apoptosis and Promotes

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