. 00-07.

, , , , , . , , , - .

1

RFn

: ,

2 3

, .

4

, . -, . .

2 / 1-4/ / - , / / /. R , , . R : /VLA 1-6, , , , , N, P, R, T (NCAM), (ICAM), 1 (VCAM-1), (MAG), (L1) D44 CBP 35 R , , .

1. . // - . - . R , . - 20 ,

3 . :

1.1.

HAV-motif

EC1 EC2 EC3 EC4 EC5 N Ca Ca Ca Ca Ca-binding dimerisation C Catenin binding

cell adhesion

- , N - , - , R/-4/ VE-/-5/. - N- HAV-Histidine-Alanine-Valine, . .. 120 550

4 110 , . - -5 12 HAV, . , . His-l-Vl , /, /; 102 , - 80 . - 20 . 2+- /-/ . , . - . 1.2. /, / , . . 1.3. / / /15-22/

5 . . , - . 1.4. 7 GPCR 9 , EGF . 1.5. FAT , EGF . . 1.6. . /- N-/ , - , - .. 102, 88 80; - . , - - . src- 120ctn .

6vinculin like splice 1 N beta-gama binding actinin binding hdmodimerisation actin binding 906 C

GSK3b arm repeat 1 N alpha catenin cadherin 781 C

APC GSK3b 1 gama N alpha catenin cadhirin 745 C

APC

-- - - -- - . - / / N b . 2. . , .

7 III / R/, . 100 , -, . 3. . R . / /. L-, - - ( ; EGF, ; -. 4. . . . R : (ICAM,VCAM-1)

8 /, , -/ R - , D9 , R. /MIDAS/. 8 .. 90-110, 4 210 , . 4 1,3,4 . .. 120-210 - , 1,2,l,m,x I 200 . I ; 3,6 , IIb

9extracellular MIDAS Ca S alpha N S C intracellular

MIDAS beta N

Cys rich

C

. , . 126 9 14 24 . , . : VL /1 , VLA; /2 LeuCAM/; /3 /

10 RGD/51; V; IIb 3 / I, , , , , . 21 1; 2 ; 4 1 ; IIb3 . . 1,3 , 64 , 2 41 47 /I/.

11

aIIb a10 Collagen R a9 b1 a8 a3 RGD R a6

b3

a2 a1 a5

b5 b6 b8 aV

a7 Laminin R a4

b4 b7 aE

aM aL

Leucocyte R aX aD

b2

b1 3 ILK/Integrin Linked Kinase/, . ANK// - , 3 / .

12ANK repeat

N

Ank

PH

k i n a s e

C

ILK ILK, Pinch 1 2 Parvin, . 3. ILKAP 2, , D1. , . / /FAK* . Tyr N SH3 N C FRNK 3 SH3 SH FAT C

e FAK / / -/FAT/ SH3 . FRNK - FAK, FAK. FAK .FERM N kinase FAT FAP C

13

FAK e FERM ; SUMO- ; ; FAT/Fokal Adhesion Targeting/ ILK; FAP/Focal Adhesion Proteins/ , . FAK , GPCR, . . . : /, , /, , , R , -. . R . -

14 , - 3 - , . - .

Rho FAK FAK PI3K

FAK

p130CAS

CD44

- , , 3, . D44

15 11 - 20 . /s1-s5/, 16-20/s6-s10/ /44s,44/. 6-15 v1v10 , v1 . v8-v10/ 44/. 100, 1,000. 361 /37-42/ . s1-s5 . s5. . 23 s8. .