c:\documents and settings\user\desktop\microsoft power point agranulocytic series+abnormal wbc

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Page 1: C:\Documents And Settings\User\Desktop\Microsoft Power Point   Agranulocytic Series+Abnormal Wbc
Page 2: C:\Documents And Settings\User\Desktop\Microsoft Power Point   Agranulocytic Series+Abnormal Wbc

Monoblast

Monocyte

Promonocyte

Page 3: C:\Documents And Settings\User\Desktop\Microsoft Power Point   Agranulocytic Series+Abnormal Wbc

MonoblastSize:- ��� ���������� 10-18 �����

Cytoplasm:-)*� +,-��*-�.-����������-�����+�/

Nucleus:- �3456��+5�7��3����� ���(folded over)

-chromatin� ���@��A��+����+��)B3���C�

-)*� +��3�D� -E/ nucleoli ��456� 1-2 �B

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PromonocyteSize:- ��� ���������� 14-18 �����

Cytoplasm:-)*� +,-��*�.,�����+�/ -E/ fine azurophilic granules

Nucleus:-�B�JKA�+5�7��3�-chromatin 5�/�L, ��+��)B3�������C� -)*� +��3�D�-E/ parachromatin-E/ nucleoli ���/��

Page 5: C:\Documents And Settings\User\Desktop\Microsoft Power Point   Agranulocytic Series+Abnormal Wbc

Monocyte

Size:- ��� ���������� 14-18 �����

Cytoplasm:-)*� +MN-�.,���������+�/ -�DE/ fine azurophilic granule- �DE/ vacuoles

Nucleus:-�B�JKA�+5�7��3�-chromatin 5�/�L, C)��B�� ���@���+��)B3�������C�

-)*� +��3�D�-E/ parachromatin

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Macrophage

Size:- ��� ���������� 25-50 �����

Cytoplasm:-�+P�*�K�� - �+ vacuoles- �+ azurophilic granule

Nucleus:-���-chromatin 5�/C�A�PQD,--�+ nucleoli 1-2 �B

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Histiocyte

Histiocyte

��� Reticuloendothelial cell (RE cell) ��������� �� �!" # $ % &! " �� �! " "!� � ' ���%� "()*+,)+-(./

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e

Page 9: C:\Documents And Settings\User\Desktop\Microsoft Power Point   Agranulocytic Series+Abnormal Wbc

LymphoblastSize:- ��� ���������� 10-18 �����

Cytoplasm: -�+P�*�K��� -����+ granules-�DE/ perinuclear zone

Nucleus:- �3456������456�- �B)� �3��� Nucleus/Cytoplasm = 5-7/1-chromatin �A��+����+��C�-E/ nucleoli 1-2 �B

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Prolymphocyte

Size:- ��� ���������� 10-18 �����

Cytoplasm:-)*� +,-��*4 -E/ azurophilic granules

Nucleus:-�B�JKA���,����@���-chromatin 5�/�L, ��+��)B3�PQ�A�/+�/C�

-�DE/ nucleoli ���

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Lymphocyte

Size:- ��� ���������� 10-15 �����()�U*���� Lymphocyte)

Cytoplasm:-)*� +,-��*4 -�DE/ azurophilic granule

Nucleus:-�����@��� ,�+ 5�7� ��P�)-chromatin 5�/ ��+��)B3C���+�/

Large lymphocyte

Medium lymphocyte

Small lymphocyte

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Large Granular Lymphocyte “N.K cell”

Spindle-shaped lymphocyte

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Atypical lymphocyte

(Transformed lymphocyte)

�PQ lymphocyte .+W����4�A�A.+W�+���P�+W�CP����P��� �7W��D�����4�A�A active stage ��� 3 C// �7�

Type IType 2Type 3

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Atypical lymphocyte type I

Size:-�PQ cell .+W�+�����C�� P�)*��������456�

Cytoplasm:-)*� +,-��*��������plasma cell �PQ foamy -�DE/ fine azurophilic granules

Nucleus:-���5�7���P�)-chromatin 5�/��+��)B3����PQ�A�/+�/

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Size:-��456��3� cell type I

Cytoplasm: -)*� +,-��*4 -�D)*� +����)���/

Nucleus:-��� , ��P�) 5�7�����nucleus ��� monocyte-chromatin 5�/��+��)B3C�

Atypical lymphocyte type II

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Size:-P�)*��@��3� cell type I

Cytoplasm: -)*� +,-��*-�D)*� +����)���/

Nucleus:-�B���� ,�+ 5�7� ��P�)-chromatin �A��+����+��)B3�PQ�A�/+�/- ��[E/ nucleoli

Atypical lymphocyte type III

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Plasmoblast

Proplasmocyte

Plasma cell

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Plasmoblast

Size:- ��� ���������� 18-25 �����

Cytoplasm: - +,-��*����-�B�JKA foamy-�+ perinuclear zone

Nucleus:-��456�,�B�U*���/ -E/ nucleoli 5���B-�DE/����+��)B3��� parachromatin �PQ��P�����3+� (Cartwheel)

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Proplasmocyte

Size:- ��� ���������� 15-25 �����

Cytoplasm: - +,-��*����-�B�JKA foamy -�+ perinuclear zone UB��D

Nucleus:-����@���-�B�U*���/ -�DE/ nucleoli 5���5�7�����

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Plasma cell

Size:- ��� ���������� 8-24 �����

Cytoplasm: - +,-��*����-�B�JKA foamy UB��D-�+ perinuclear zone ���UB�

Nucleus:-����@���-�B�U*���/ -�DE/ 2 nucleus -�+ parachromatin UB��D

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Page 22: C:\Documents And Settings\User\Desktop\Microsoft Power Point   Agranulocytic Series+Abnormal Wbc

������������� ���������������������������������������� �!�"#�����$%���#���&%���$% '(��#���&%���$%�!��)��%�)��:

•Congenital abnormalities•Acquired abnormalities

������������ ��&%���$% ������+ 2222 ��� ,���-.��1.1.1.1. CytoplasmicCytoplasmicCytoplasmicCytoplasmic abnormalities abnormalities abnormalities abnormalities

• .���&%���$% �������������� granulegranulegranulegranule

• �����%�/�������" cytoplasmcytoplasmcytoplasmcytoplasm ((((vacuolization) vacuolization) vacuolization) vacuolization)

2.2.2.2. Nuclear abnormalitiesNuclear abnormalitiesNuclear abnormalitiesNuclear abnormalities

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0 �PQ Large azurophilic granules ��456� 5�/ C�A)*� +����

0 E/���4]3A:- Infections- Serious burns- Septicemia- drug poisoning

Cytoplasmic abnormalities

.���&%���$% �������������� granule

Normal1.Toxic granule

Toxic granule

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0 Congenital (autosomal recessive)0 �PQ granule �+��456�)*� +��3�C��(Abnormal azurophilic granules) E/���4��@���7���3.̀�U*�0 Susceptible to infection�+�B�JKA��3��B/albinismC�A bleeding tendency

2.Chediak- Higashi anomaly

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0 )A������@���@���� 5�7���P��� �� 1-4 µm0 )*� +,-��* �B�DA����U*���/�b��� bLW�E/���4 bandform, neutrophil0 Aggregates of Rough endoplasmic reticulum0E/4]3A:

- Several toxic status- Severe burn- Burns- Chemotherapy- Malignant disease- Pregnancy

0 DA5��P��7W���B/��� ��]3AP�)*

3. Döhle bodies

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4. Alder-Reilly anomaly

0 Autosomal recessive trait0 E/ granule ��@���456� )*� +��3�������AD�.B / nucleus � � � neutrophil C � A � DE/ 4 lymphocyte 5�7� monocyte0 ���� Toxic granules

0 C���3�C)�)��.+W Cytochemical stains:h����� Alder-Reilly45���/3�4��������3� Toluidine blue stain C�A Colloidal iron stain �3 Toxic granule 45��� i�/j.B,����

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5. Auer rod

0 �PQC.�� + ��3�-C�� 0 ��*�D� Abnormal development of

primary granules0 E/4]3A Leukemic Blood cells ���

- Myeloblast- Promyelocyte- Monoblast

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6. May-Hegglin anomaly

0 Autosomal dominant trait 0 �B�JKA�PQ����� 1-3 m, + blue-gray ���� Döhle bodies C)�DAE/)����P 0 ��*�D� Aggregates of mRNA0 �B�E/��3��B/

LeukopeniaThrombocytopeniaE/ Giant platelets

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0 4]3A.+W�+��)*��U7,������̀C��

1 ��E/ vacuole ��3��B/���+ toxic granule 4 neutrophil DAU�3�/��U+,���+]3A septicemia

0 ����@/)B3������7���3�4 ��B��7��C�@�C�A)B,��3�.+W�̀K5]��*5��� ��* 4 UBW3h��

Cytoplasmic abnormalities

/�������" cytoplasm (vacuolization)

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Nuclear abnormalities

1. Hypersegmentation

0 Nucleus C/���PQ lobe ���3� 5 lobes �L,�P 0 ihypersegmented neutrophilj0 Vit.B12 or Folic acid Deficiency(Megaloblastic anemia or Pernicious anemia)

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0 h���)*4 nucleus �����@���7���3DB/��̀���BC� .-45�E/ neutrophil �+ 2 lobe ����C3�) �B�JKA���� band form 0 Congenital (Autosomal dominant) 0 Acquire

h����7��.+W�+���D�*6�������A������*�P�)* (myeloproliferative disorder)�+��)*��U7,��̀C��

2. Pelger-Huet anomaly

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3. Pyknotic cell

0Nucleus �+����@��� �3��B�PQ�����+�3 C� C�A�PQ�B33 0Cytoplasm �B��� ]E45��5@���� 0E/4�b���.+W�-�B�DA ��)B3

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0 �PQ U*, �3��� cells .+W)�C��3 nucleus [��.-�� DL��5@�PQ���C5 0 ��[E/���P�)*C�AE/������3�P�)*4 Leukemic blood cell h���sEA4 Chronic Lymphocytic Leukemia (CLL)

4. Smudge cell or basket cell

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0 �PQ WBC h���sEA PMN .+W�* hematoxylin body0 ��*�D�:Autoimmune disease h�����Pu3��+ Antinuclearfactor (ANF)0�PQPv*��*� Antigen-antibodies complex ��+�� complex+,3� Hematoxylin body (Nucleus:ANF)0 �+ Complement���A��A)̀�45���*��/3�� Chemotaxis

0 PMN ���A�3��B��+�� Rosettes form0 PMN �E+��)B3��+�3.+W�* Hematoxylin body ����P��+��3� iL.E cellj

Rosettes form

L.E.Cell

1. L.E cell

Other

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0 �7� monocyte 5�7� neutrophil .+W��*� phagocytosis0 �B����5@�B�JKAh���)*��� nucleus ����b���.+W[���*����PUB��D

2. Tart cell

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