Sanford-Burnham Medical Research Institute

Challenging Disease, Revolutionizing the Understanding of Human Health

It’s hard to imagine results that will matter more.

We are honored by your interest in Sanford-Burnham Medical Research Institute.

Whether you come from the business world, as we do,or from any other walk of life, results are what matter.Results are equally important to the scientists who work at Sanford-Burnham. Their pioneering spirit hasproduced valuable breakthroughs, and their successinspires researchers around the world.

Your generous support will accelerate research thatholds the power to cure. You can help hasten the discoveries that can change the lives of millions. Join us!

Sincerely,

T. Denny Sanford Malin Burnham

You are invited to invest in a truly distinctive philanthropic opportunity.

Through your support of Sanford-Burnham Medical Research Institute, you will help revolutionize the way disease is treated, diagnosed, and prevented—improving the lives of millions of people.

Sanford-Burnham is one of the few research institutes in the world expressly focusedon narrowing the distance between fundamental laboratory research and patient care.

There is no time to lose.Even though biomedical researchers have decoded the human genome and unlockedmany of the intricate mysteries of cell biology, the pipeline of new treatments and diagnostic tests is drying up. Unfortunately, it can take 15 years and more than $1.5 billion to move a promising therapy from the laboratory into clinical use.

Patients suffer when promising research is so slowly translated into new therapies.

Revolutionizing the understanding

Sanford-Burnham is accelerating innovation in adynamic environment free of distractions and untaintedby bureaucracy. Sanford-Burnham’s collaborative culture builds bridges between cutting-edge laboratoryresearch and the discovery of innovative new medicinesand informative diagnostics that match the right therapyto the right patient. Sanford-Burnham achievesimproved healthcare outcomes with efficiency neverbefore attained. Their research will help patients battling chronic or life-threatening conditions—sooner, rather than later.

In short, Sanford-Burnham scientistsare achieving resultsand putting them towork to save lives.

of human health.

From research, the power to cure.

Sanford-BurnhamMedical ResearchInstitute is:DrivenImpactfulCollaborativeInnovative Compelling

Driven

Sanford-Burnham is driven by the quest tounderstand human disease at its fundamentalmolecular and genetic level. Finding answersabout how cells behave in diseased versushealthy states is essential to developing newstrategies for treatment, diagnosis, and prevention of disease. There is palpable energyat Sanford-Burnham that inspires people toexplore the unknown and dare to challenge conventional approaches.

Drive. Duc Dong, Ph.D., and his lab study diabetes at its fundamental molecular level.

ImpactfulThe discoveries unfolding at Sanford-Burnham impact scientists worldwide. The Institute’s impact in science and medicine is evident in our impressive track record of inventing breakthrough medicines and diagnostics.

The impact of our research is evident in that our publications have been cited more often in peer-reviewed biology and biochemistry journals during the pastdecade than any other organization worldwide—including all medical centers, research institutions, companies, and universities. What’s more, the vast majority of our journal articles illuminate key facets of translating research into prototypetreatments for patients.

Impact. Brandon Nelson is Manager of the Stem Cell Core, one of the Institute’s shared technology centers.

U.S. government statistics rank Sanford-Burnham among the very best in the nation incapital efficiency of generating intellectual property, defined by the number of patentsissued per grant dollars spent. More than anything we do at Sanford-Burnham, patentshelp to stimulate the economy, serving as the foundation upon which new companies are built and jobs are created.

Take a moment to look at our track record of inventing new breakthrough medicines and diagnostics. Much has been accomplished, especially when considering that theworkforce at Sanford-Burnham is a fraction of the size of major research universities.Among noteworthy highlights of Sanford-Burnham research with clinical impact are:

• Invention of the underlying technology for the PSA test, the first blood test for early detection of prostate cancer.

• Contribution of enabling technology used to produce the first “biotech drug” (recombinant protein) for anemia.

• Invention of tumor-targeting drug technology, now in Phase III clinical trials, the final step toward FDA approval.

• Discovery of the first DNA-based drug for cancer treatment to successfully complete Phase III clinical trials.

• Generation of prototypes of two drugs used to prevent heart attack and stroke by inhibiting blood clotting.

• Development of a technique to pull cancer-fighting medications deep into hard-to-penetrate solid tumors.

To date, inventions by Sanford-

• Discovery of the neuroprotective actions ofthe first FDA-approved drug for Alzheimer’sdisease that actually prevents cell death,rather than merely masking the symptoms ofnerve cell loss like other currently availablemedicines.

• Generation of one of the first “vitamin-based”drugs for cancer, tapping into naturally occur-ring cancer defense mechanisms in the body.

• Invention of seminal technology for a newnerve repair treatment drug.

• Development of monoclonal antibody technologies for preventing fibrosis (scarring), now in advanced clinical testing.

• Discovery of protein drugs that neutralizetumor growth factors, now in Phase II clinicaltrials.

• Invention and development of innovative imaging agents that bind tumor blood vessels for improved detection of cancer.

• Demonstration in patients with chronic HIV infection of the brain that a neuroprotectivedrug used for Alzheimer’s disease can slow progression of dementia.

Burnham have resulted in over 600 issued patents.

Collaborative

Collaboration is the cornerstone of Sanford-Burnham Medical Research Institute. Sanford-Burnham recognizes that tackling theworld’s greatest medical challenges demands a team approach,where diverse skills, talents, and resources are organized akin to a “Manhattan Project” in a coordinated effort to conquer specific diseases. The Institute’s commitment to collaboration as a fundamental strategy for achieving superior results is so strong that the word “collaborative” appears in the Sanford-Burnham mission statement.

Collaboration is built into the DNA of Sanford-Burnham MedicalResearch Institute. We extend our collaborative spirit beyond theInstitute to benefit from partnerships with scientific and medical colleagues around the world. We are as collaborative externally as we are internally. Collaboration saves money, and even moreimportant, collaboration saves time and delivers results faster.

Collaborate. Jose Luis Millán, Ph.D.,and postdoctoral researcher NadiaBorowski Scott share their thoughtson an experiment in Dr. Millán’s lab.

The Institute’s structure is designed to achieve results through a multi-disciplinaryapproach that brings scientists and other professionals together to build “dream teams”that take on the most difficult diseases. This approach leverages the power of five discovery research centers that work closely together in partnership, fueling cross-fertilization of ideas that yield new insights and spark innovations:

• NCI-designated Cancer CenterOne of the preeminent cancer research centers in America, the Center investigates the causes of cancer and translates these discoveries into new ways to diagnose andtreat it. The Cancer Center is one of only seven basic science research centers, asselected by the National Cancer Institute (NCI) and has maintained this designation since1981. Sanford-Burnham is one of only three organizations specifically chosen by NCI tolead the nation’s efforts in producing the next generation of cancer medicines, serving as a “comprehensive” drug discovery center for the NCI Chemical Biology Consortium.

• Del E. Webb Neuroscience, Aging and Stem Cell Research Center The Center studies degenerative diseases and seeks to find new treatments forAlzheimer’s disease, Parkinson’s disease, and other neurological conditions. The Centeralso investigates the cellular mechanisms underlying aging to help people enjoy betterquality of life as they age. One of the hallmarks of the Center is its world-class stem cellresearch, which studies ways to regenerate diseased tissues for a variety of maladies,including heart disease, diabetes, paralysis, stroke, and many other conditions. Amongother distinctions, the Center is designated by the National Institutes of Health (NIH) as a national center of excellence for Parkinson’s disease and a regional resource for neuroscience research.

Leveraging the power of fivediscovery research centers.

• Infectious and Inflammatory Disease Center The Center investigates a wide variety of chronic conditions, such as rheumatoid arthritis, lupus, and Crohn’s disease, in which the immune system inadvertently attacksthe body. Researchers are also investigating infectious diseases with a focus on “emerging” pathogens. One of the Center’s goals is to develop new medicines to attack bacteria and viruses that have become resistant to current treatments.

• Diabetes and Obesity Research CenterWith obesity now at epidemic proportions, this Center seeks to understand why people develop metabolic syndrome, insulin resistance, and ultimately type 2 diabetes.Researchers are also investigating various causes of cardiovascular disease. A major goal of the Center is to use genomics and metabolomics to help devise personalizedtreatments for patients with diabetes, obesity, and heart disease.

• Sanford Children’s Health Research CenterResearchers here are working to solve some of the most pressing childhood medicalproblems, such as type 1 (juvenile) diabetes, autism, and muscular dystrophy. The Center is also a world leader in the study of rare hereditary diseases. Using high-throughput chemical screening to find medicines that reverse inborn defects,Sanford-Burnham brings hope to children affected with devastating “orphan” diseases that are largely ignored by the pharmaceutical industry. This Center works in collaboration with Sanford Health, a large healthcare organization with cutting-edgepediatric medicine programs.

Innovative

We strive to transform the way medical research is conducted, overcoming barriers and creating new models that improve efficiency of the discovery research process. We are not afraid to assume the risks necessary to realize the rewards of leadership in promising new areas of medical research.

We attract researchers who are creative, daring, and dedicated to working together onthe biggest challenges in medicine. Importantly, unlike for-profit company environments,Sanford-Burnham scientists are free to pursue discoveries wherever insights lead.

Sanford-Burnham also teaches innovation—the lifeblood of future economic growth andthe key to cures. The Institute nurtures the next generation of researchers. For example,recognizing that great breakthroughs often come from the convergence of technologiesoriginating from different fields, we offer an innovative graduate program in BiomedicalSciences. This graduate degree (Ph.D.) program gives students a foundation in four disciplines (biology, chemistry, biophysics, and either engineering or computational biology),aiming to create a next generation of bridge-building scientists who will spearhead cross-fertilization of ideas and catalyze communication among diverse groups of scientists.

The pioneering spirit inspires everything that happens at Sanford-Burnham Medical Research Institute. Our scientists are creative, courageous, confident, and motivated by the passion to improve human health.

Innovate. Sanford-Burnham scientists strive to transform the way research is conducted.

Compelling

Your generous support has the potential to savethe lives of millions of people. Imagine what your gift means to those who suffer from life-threatening diseases—conditions that may becured tomorrow thanks to your generosity today.

Accelerating innovation and improving humanhealth, your gift will fulfill the promise ofresearch with the power to cure.

Compel. Salvatore Abani, Ph.D.,M.D., exhibits a passion foundthroughout the Institute, for translating basic research into treatments and cures.

Sanford-Burnham Medical Research Institute presents a compelling opportunity formaximum philanthropic impact.

Specifically, your support will make a significant difference by:• Providing the necessary resources to form world-class scientific teams

committed to tackling daunting diseases and spearheading strategies for significant progress.

• Promoting research in promising, high risk/high reward areas not currentlyfunded by conservative government or industry sponsors.

• Prompting new drug development by funding the gaps that impede translation of discoveries into cures.

And, your gift will be leveraged ten-to-one (10:1), enormously expanding its impact.At Sanford-Burnham, every dollar of philanthropic support is historically parlayed by our researchers into ten dollars of competitive grant funding. Moreover, becauseSanford-Burnham does not practice academic traditions such as tenure, where faculty past their prime exhaust much of the organizational resources, you can rest assured that your gift will fuel cutting-edge science that moves the worldforward in our quest for cures.

Please make your gift today.

Join us in our extraordinary questto challenge diseaseand revolutionize the understanding of human health.

From the moment of its founding, the Institute has been blazing trails.

In 1976, Dr. William Fishman and his wife Lillian left their comfortable life at a prestigiousuniversity in Boston to become the founders of what would eventually emerge asSanford-Burnham Medical Research Institute. The Fishmans discovered that many cancers have a “fetal” signature, suggesting that perhaps malignant cells revert back tothe more primitive state from which adult cells emerge during fetal development. In fact,they had discovered that many cancers arise from adult stem cells, now recognized as a central tenant in cancer biology. They staked everything on their belief that the secretto cancer treatment lay in studying developmental biology in tandem with oncology. They called this new enterprise the La Jolla Cancer Research Foundation.

In 1996, honoring the generosity of Malin Burnham and family, the Foundation wasrededicated as The Burnham Institute, later updated to Burnham Institute for MedicalResearch.

In 2009, the Institute’s Florida campus debuted at Lake Nona in Orlando, made possibleby funding from the State of Florida, the City of Orlando, Orange County, the TavistockGroup and numerous philanthropic gifts. Situated at the crossroads of a new “medicalcity,” it provides additional momentum for research matched to urgent patient needs.

History of Sanford-Burnham Medical Research Institute

On January 26, 2010, during a ceremony presided over by Malin Burnham, the Institute became Sanford-Burnham Medical Research Institute in recognition of the transformational support of T. Denny Sanford.

Throughout its history, the Institute has benefitted from dynamic leadership of prominent physician scientists.

John C. Reed, M.D., Ph.D., is currently Chief Executive Officer and holder of the Donald Bren Chief Executive Chair. Dr. Reed is a world leader in cell biology and cancerresearch. He was recognized by the Institute for Scientific Information as the biomedical researcher whose work was cited most often by other researchers during the decade1995-2005. Dr. Reed has authored more than 800 papers and 50 book chapters; his workhas culminated in more than 100 patents and several medicines now in clinical testing.Under Dr. Reed’s leadership, Sanford-Burnham has evolved to become a world-leadingbiomedical research institute with over 1,200 employees working at three locations.

Serving as Sanford-Burnham’s President and holder of the Pauline and Stanley Foster Presidential Chair, Kristiina Vuori, M.D., Ph.D., is renowned for her research on meta stasis, the most-life threatening aspect of cancer. While continuing to manageher laboratory as well as heading the NCI-designated Cancer Center, Dr. Vuori alsooversees scientific programs and operations at Sanford-Burnham.

From research,the power to cure.

Sheila Collins, Ph.D., is part of thedynamic faculty in the Institute’s

Diabetes and Obesity ResearchCenter, located in Orlando, Florida.

www.sanfordburnham.org