cardiology in a heartbeat
TRANSCRIPT
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Cardiology in a heartbeatYour hosts: Malik ‘heart throb’ Fleet and Thomas ‘heart ache’ McLeod
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Objectives
Be able to perform in a cardio related osce.
Describe the key features and management of: Atrial Fibrillation Acute Coronary Syndrome
Answer SBAs related to this week’s teaching
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Outline of session
20 minutes OSCE and debrief
40 minutes tutorial
20 minutes SBAs
Answer any questions
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Notes from the OSCE scenario
DR ABCDE: (Before ‘D’!)
Ask examiner for observations
Does patient meet PERT criteria? They always do so call for help!
(PERT criteria=
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Notes from the OSCE scenario
D - anger R - esponse A -irway B- reathing C - irculation D - isability (AVPU) E - xposure
LOOK
FEEL
LISTEN
MEASURE
TREAT
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Notes from the OSCE scenario
A - irway: Look Feel Listen Measure Treat
Often patient is breathing so able to say airway is patent. If not, suggest ensuring airway e.g Guedel airway
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Notes from the OSCE scenario
B- reathing Look: cyanosed? Trachea central? Chest expansion? Feel: symmetrical chest movement? Percussion? Listen: auscultate chest (ask examiner for findings) Measure:
a. Resp rate B. O2 sats on air
Treat: Give oxygen: high flow (e.g. 15L/min) - non
rebreathe mask (unless C/I e.g COPD)
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Notes from the OSCE scenario
C- irculation Look: cyanosed? General appearance? JVP? Pain? Feel: Peripheries- cool? Clammy?; Pulse Listen: heart sounds Measure:
Heart rate Blood pressure Cap refill Urine output Temp. ECG
Treat: IV access (“two wide bore cannulae”) Bloods (FBC/ U and E) Fluid Challenge (MONA if acute coronary syndrome)
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Notes from the OSCE scenario
D- isability: AVPU + BM Patient responds to:
A - lert V - oice P - ain U - nresponsive
Ask examiner for BM
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Notes from the OSCE scenario
E- xposure: Expose patient from head to toe looking for
any other clue for deterioration.
+ “ending exam”: write notes, hand over to team etc.
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Notes from the OSCE scenario:
8 Reversible causes of VT: The 4 ‘H’s and 4 T’s.
4 T’s:
T-hrombosis (coronary or pulmonary)
T-amponade
T-oxins
T-ension pneumothorax
4 H’s:
H-ypoxia
H-ypovolaemia
H-ypo/er kalaemia (metabolic)
H-ypothermia
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Notes from the OSCE scenario:
2 shockable rhythms: Pulseless Ventricular Tachycardia Ventricular Fibrillation
2 non shock: -Pulseless electrical activity -Asystole
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Notes from the OSCE scenario:
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Tutorial: Atrial Fibrillation
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AF: Objectives
By the end of this session you should be able to:
Identify how AF presents and establish an appropriate differential
Suggest sensible investigations as relating to your differential
Recognise and describe the classic ECG findings and the pathophysiology of AF.
Classify AF as according to its pattern and amenability to cardioversion (‘the 3 P’s)
Describe the management options in terms of Rate and Rhythm control and list suitable examples of patients and medications accordingly.
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Case: “Jo-Jo”
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“Joe” Joe is a 45 year old professional clown.
He has recently returned from a boozy working holiday in Magaluf.
He has the biggest performance of his career at the Brent Cross circus tomorrow. He feels terribly unprepared and begins to sweat when talking about it.
He presents to you in A and E complaining of being aware that his heart is doing ‘funny things’ and feels short of breath.
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Differential Diagnosis at this stage?
Anxiety induced palpitations (panic attack)
Atrial Fibrillation
(hyperthyroidism)
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Examination
“irregularly irregular”* *NICE recognise as very ‘sensitive’ sign for dx of AF. Regular radial pulse= 96% negative predictive value.
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Investigations:
ECG: (Please present)Joseph Jackson D.O.B: 16/3/ 1967
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AF: ECG findings and pathophysiology ECG findings:
Absent p waves ~ no identifiable p waves throughout trace. Narrow QRS (AV conduction in tact)
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AF: ECG findings and pathophysiology Pathophysiology:
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Diagnosis= AF. What are you worried about?
AF: Risk of: EMBOLISM STROKE
Haemodynamic compromise
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Other investigations:
+/-
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Case development
History: diagnosed with hypertension 10 years ago. Stopped taking ‘useless tablets’ after 6 months. Father died at 60 from hypertensive heart disease/failure.
Ix: No echo done Bloods: TFTs: negative
Troponin: negative
Joe begins to feel worse, his heart rate increases to 150 bpm and he has slight pain. No ST elevation on ECG.
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AF: Management: “The Blender”
“Rate” or “Rhythm” Control
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AF: Management: Acute Onset
If HAEMODYNAMIC INSTABILITY:
Non Life threatening:
-RATE (if major contributor to haemodynamic instability):
-Beta Blocker / Ca Channel Blocker
-Amiodarone
-RHYTHM:
-PCV* (or ECV if available)
*Pharmacological Cardioversion:
I.V Amiodarone
-ANTICOAGULATION:
-start heparin
- commence oral warfarin depending on outcome of CV/ onset of AF.
Life threatening:
-RHYTHM:
Emergency electrical cardioversion
-(Anticoagulation should not delay intervention).
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AF: Rhythm Control: Cardioversion
Pharmacological Electrical
< 48 hours > 48 hours
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AF: Rhythm: Cardioversion: WARNING!
AF = clot generator
Normal rhythm (cardiac output restored)
clots disseminated to brain etc.
CARDIOVERSION
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AF: Rhythm: Cardioversion: VTE prophylaxis
<48 hours
-Heparin
-PCV (or ECV)
-Confirm onset of AF:
-If definitely <48hours: no need for further anticoagulation.
-If unsure: warfarin for 4 weeks
>48hours
a. ANTI COAGULATE (3 weeks)
or
b. TRANS OESOPHAGEAL ECHO (TOE)
-detects whether a thrombus is present or not.
-If not: heparin + cardioversion
-If present: warfarin for 3 weeks and repeat TOE.
* Continue warfarin for 4 weeks post cardioversion
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AF: Rhythm: Cardioversion: VTE prophylaxis
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AF: Rhythm: Cardioversion: PHARMACOLOGICAL
<48 hours
Flecainide Amiodarone NO structural heart disease* YES structural heart disease*
(<8 hours) (>8 hours)
*Structural heart disease defined as: “coronary artery disease or LV dysfunction”
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AF: Rhythm: Cardioversion: ELECTRICAL
>48 hours
ECV (= low grade shock to heart): 1st line: > 48 hours
If doubts over success (e.g. previous failure to cardiovert; early recurrence of AF): Give AMIODARONE or SOTALOL for 4 weeks prior to ECV.
Improves rates of cardioversion
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Atrial fibrillation: “3 p’s” Classification
Paroxysmal: Spontaneous self termination <7 days (often <48hours)
Persistent: Lasts > 7 days NOT self terminating
Permanent Does not terminate Not amenable to cardioversion (NOTE: can return to sinus rhythm if cure underlying pathology e.g.
hyperthyroidism)
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AF: Management: Paroxysmal
Classified as…
Therapeutic objective: SUPPRESSION OF PAROXYSMS
Paroxysm defined as…
From the Greek…
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AF: Management: Paroxysmal
Classified as… Spontaneous self termination <7 days (often <48hours)
Paroxysm defined as…"sudden attack, outburst"
From the Greek… (παροξυσμός paroxusmos), "irritation, exasperation".[
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AF: Management: Paroxysmal
Suppression of paroxysms:
CONSERVATIVE:
1.there is a known precipitant of paroxysm E.g. Alcohol; caffeine.
2. the patient asymptomatic/few symptoms
3. No history of left ventricular dysfunction/ ischaemic heart disease
Rx: -drug free / “pill in the pocket” strategy:Pill in a pocket= “Flecainide” (or other Class 1c agent)
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AF: Management: Paroxysmal
Suppression of paroxysms:
MEDICAL/ PHARMACOLOGICAL:
-If patient is symptomatic-Frequent paroxysms-No known precipitant
1st Line: Beta Blocker
2nd line (symptoms not controlled): Sotalol
3rd line/ if poor left ventricular function: Amiodarone
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AF: Management: Persistent
Classified as…
Therapeutic objective: think blender: control the rate or rhythm.
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AF: Management: Persistent
RHYTHM vs RATE
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AF: Management: Persistent: RATE
RATE control strategy should be preferred 1st line option in:
Over 65s
Coronary artery disease
C/I to antiarrhthymic drugs
Not suitable for cardioversion
No heart failure
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AF: Management: Persistent: RATE
RATE control 1st line option: Beta blocker/ rate limiting Ca channel blocker
Monotherapy: Beta blocker Ca Channel Blocker (Digoxin ~ if sedentary)
If require more than monotherapy: Beta blocker/ Ca channel blocker + Digoxin
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AF: Management: Persistent: RHYTHM
RHYTHM control strategy should be preferred 1st line option in:
Younger patients
Symptomatic
AF secondary to treated/ corrected precipitant (e.g. chest infection)
With heart failure
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AF: Management: Persistent: RHYTHM
RHYTHM control strategy 1st line option is:
Cardioversion + Anticoagulation
If recurrence/ unsuccessful/ requires drug to maintain sinus rhythm:
1st line: Beta Blocker
2nd Line (I.e. not effective/ contraindicated):+ structural heart disease :AMIODARONE - NO structural heart disease: FLECAINIDE (or Sotalol)
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AF: Management: Permanent
Classified as…
Therapeutic objective: think blender: control rate as rhythm functions are broken!
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AF: Management: Permanent
RATE only!
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AF: Management: Permanent: RATE
RATE control 1st line option: Beta blocker/ rate limiting Ca channel blocker
Monotherapy: Beta blocker Ca Channel Blocker (Digoxin ~ if sedentary)
If require more than monotherapy: Beta blocker/ Ca channel blocker + Digoxin
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AF: Management: ANTICOAGULATION Acute:
Commence heparin until full risk assessment of emboli has been performed. >48 hours- 3 weeks of oral anticoagulation (warfarin) prior to cardioversion
NO anticoagulation if: Stable sinus rhythm has been restored <48 hours No risk factors for emboli
Chronic:
Discuss with patient risks and benefits of anticoagulation.
CHADS 2 = predictor of stroke.
C= congestive cardiac failure (1)
H= hypertension (1)
A = age (>75) (1)
D= Diabetes (1)
S= stroke/ previous TIA (2)
Warfarin : aim for therapeutic INR 2 -3 (If warfarin C/I : Aspirin 300 mg/day)
CHADS 2 score of: % risk of stroke
0: 1.9%
6: 18.2%
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AF: Summary
You should now be able to:
Identify how AF presents and establish an appropriate differential
Suggest sensible investigations as relating to your differential
Recognise and describe the classic ECG findings and the pathophysiology of AF.
Classify AF as according to its pattern and amenability to cardioversion (‘the 3 P’s)
Describe the management options in terms of Rate and Rhythm control and list suitable examples of patients and medications accordingly.
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Tutorial: Acute Coronary Syndrome
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Case
57 year old Gavin stumbles into A&E complaining of severe chest pain. He’s grey and very sweaty.
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Objectives
Pathophysiology Definitions Presentation Investigations Management of STEMI
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What causes ischaemic heart disease?
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Fatty streak > Simple plaque > Complicated
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Risk Factors
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Non-modifiable
Age Gender (males are at greater risk) family history of IHD
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Modifiable
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Definitions
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Acute Coronary Syndrome
Unstable Angina NSTEMI STEMI
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Ischaemia Reduced perfusion. Purely symptomatic. No cell
death
InfarctionReduced perfusion exceeding tolerance of cells. Cell
death
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Ischaemia Reduced perfusion. Purely symptomatic. No cell
death• Stable Angina• Unstable Angina
InfarctionReduced perfusion exceeding tolerance of cells. Cell
Death• NSTEMI• STEMI
Clinical Application
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Acute Coronary Syndrome
Unstable Angina NSTEMI STEMI
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Differentiate?
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ECG
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Troponin
0Hrs 12Hrs
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Unstable angina
ST elevation
Troponin +ve
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NSTEMI
Troponin +ve
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STEMI
ST elevation
Troponin +ve
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Back to the case
What next?
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History and Examination
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Investigation.
ECG & Troponin
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Anatomy
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ST: Elevation: Localisation
Right Left
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ST: Elevation: Localisation
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ST: Elevation
Mechanism behind ECG changes:
Complete occlusion of coronary vessel leads to ischaemia/infarction which is seen as ST elevation.
The mechanism is, however, poorly understood.
Injury wave hypothesis= abnormal currents are generated between normal and infarcted tissue and detected as an ‘injury wave’.
Localisation: Right Coronary Artery (Post. Descending/ Marginal): Inferior STEMI: Leads II, III, avF Left Anterior Descending: Anterior STEMI: V1-V4 Left circumflex: Lateral STEMI: I, aVL, V5, V6
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Gavin’s ECG
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Initial Treatment
Morphine – 5-10mg IV (+ metoclopramide) Oxygen – aim for SaO2 > 95% Nitrate – 2 puffs or 1 tablet Aspirin – 300mg PO
Restore coronary perfusion
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Restore Coronary Perfusion
Primary PCI Rx of choice if within 12h
Thrombolysis Contraindicated beyond 24hr Streptokinase, Alteplase
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Gavin has Primary PCI at the London Heart Hospital. He survives and is very grateful.
What is the next stage of his management?
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Subsequent Management
Modifiable risk factors
Antiplatelet – Aspirin, Clopidogrel B-blockers Statin ACE
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Summary
Pathophysiology Definitions Presentation Investigations Management of STEMI
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A 45 year old man suffers sudden central chest pain while at rest. It spreads across his chest and up to his neck. After 20 mins, the pain has not eased and he is increasingly sweaty and short of breath. This is the third such episode in the last 3 months
12hr Troponin I <0.05 ug/L
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What is the single most accurate classification of this event?
A. Acute Coronary SyndromeB. Non-ST elevation myocardial infarctionC. ST elevation myocardial infarctionD. Stable anginaE. Unstable angina
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What is the single most accurate classification of this event?
A. Acute Coronary SyndromeB. Non-ST elevation myocardial infarctionC. ST elevation myocardial infarctionD. Stable anginaE. Unstable angina
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A 55 year-old woman has noticed her heart beating fast. It happens infrequently and is not assosciated with any other symptoms. She is anxious about the cause of these attacks as she has no other medical problems.
HR 80bpm, BP 115/75mmHg
After a normal ECG, a 24hr tape is performed
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Which is the single most appropriate treatment?
A. Amiodarone 100mg PO once dailyB. Digoxin 62.5mcg PO once dailyC. Flecainide 150mg PO as requiredD. Metoprolol 25mg PO twice dailyE. Sotalol 40mg PO twice daily
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Which is the single most appropriate treatment?
A. Amiodarone 100mg PO once dailyB. Digoxin 62.5mcg PO once dailyC. Flecainide 150mg PO as requiredD. Metoprolol 25mg PO twice dailyE. Sotalol 40mg PO twice daily
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SBAs:
Which of the following is not a reversible cause of cardiac arrest?
Hypoxia Hypo/Hyperkalaemia Tension Pneumothorax Hyperthyroidism Tamponade
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SBAs:
Which of the following is not a reversible cause of cardiac arrest?
Hypoxia Hypo/Hyperkalaemia Tension Pneumothorax Hyperthyroidism Tamponade
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SBAs:
A 67 year old lady has just been diagnosed with persistent AF. Cardioversion has previously failed. She is symptomatic, has coronary artery disease but no heart failure. What1st line treatment would you prescribe?
Paracetamol Beta Blocker Flecainide Sotalol Amiodarone
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SBAs:
A 67 year old lady has just been diagnosed with persistent AF. Cardioversion has previously failed. She is symptomatic, has coronary artery disease but no heart failure. What1st line treatment would you prescribe?
Paracetamol Beta Blocker Flecainide Sotalol Amiodarone
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A 48-year old patient gives a 5 day history of dyspnoea. He is found to be in atrial fibrillation. Which is the most appropriate management plan?
A. Chemical cardioversion with IV amiodaroneB. Chemical cardioversion with IV flecainideC. Anticoagulation with warfarin and rate controlD. Transthoracic echocardiogram to exclude thrombus
followed by DC cardioversionE. Anticoagulation with warfarin then initiation of oral
amiodarone
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A 48-year old patient gives a 5 day history of dyspnoea. He is found to be in atrial fibrillation. Which is the most appropriate management plan?
A. Chemical cardioversion with IV amiodaroneB. Chemical cardioversion with IV flecainideC. Anticoagulation with warfarin and rate controlD. Transthoracic echocardiogram to exclude thrombus
followed by DC cardioversionE. Anticoagulation with warfarin then initiation of oral
amiodarone