Inpharma 1482 - 9 Apr 2005

Candesartan + nifedipine a nicecombo for essential hypertensionThe combination of candesartan cilexetil plus

controlled-release nifedipine is superior to candesartanalone in the treatment of essential hypertension, reportresearchers from Japan.

In their study, 258 such patients whose BP had notbeen adequately controlled with low-dose candesartanwere randomised to receive candesartan 8mg pluscontrolled-release nifedipine 20mg (n = 130), orcandesartan monotherapy titrated to a maximum doseof 12mg, once daily for 8 weeks.*

Systolic BP and diastolic BP were significantly reducedfrom baseline in both treatment groups. However, thereduction was significantly more pronounced in patientsreceiving candesartan plus nifedipine than incandesartan recipients (–12.1/8.7 vs –4.1/4.6 mmHg).Furthermore, a significantly higher proportion ofpatients achieved target BP** during treatment withcandesartan plus nifedipine, compared withcandesartan alone.* The study was supported by Bayer Yakuhin.** Japanese Society of Hypertension BP goals for patients aged< 60 years and those aged 60–69 years are < 130/85 and< 140/90 mmHg, respectively.

Hasebe N, et al. Controlled-release nifedipine and candesartan low-dosecombination therapy in patients with essential hypertension: the NICE Combi(Nifedipine and Candesartan Combination) Study. Journal of Hypertension 23:445-453, No. 2, Feb 2005 800992095

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Inpharma 9 Apr 2005 No. 14821173-8324/10/1482-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved