CANCER IN TRANSPLANTATION - PREVENTION AND TREATMENT

Transplantation and Clinical Immunology Symposia Fondation Marcel Merieux

VOLUME 27

Cancer in Transplantation: Prevention and Treatment Proceedings of the 27th Conference on Transplantation and Clinical Immunology, 22-24 May 1995

organized by Fondation Marcel Merieux and Universite Claude Bernard-Lyon I

Edited by

J.L. Touraine J. Traeger H. Betuel J.M. Dubernard J.P. Revillard C. Dupuy

KLUWER ACADEMIC PUBLISHERS DORDRECHTI BOSTON I LONDON

A C.I.P. Catalogue record for this book Is available from the Library of Congress.

ISBN-13: 978-94-010-6563-4 e-ISBN-13: 978-94-009-0175-9 001: 10.1007/978-94-009-0175-9

Published by Kluwer Academic Publishers, P.O. Box 17,3300 AA Dordrecht, The Netherlands

Kluwer Academic Publishers incorporates the publishing programs of D. Reidel, Martinus Nijhoff, Dr W. Junk and MTP Press.

Sold and distributed in the U.S.A. and Canada by Kluwer Academic Publishers, 101 Philip Drive, Norwell, MA 02061, U.S.A.

In all other countries, sold and distributed by Kluwer Academic Publishers Group, P.O. Box 322, 3300 AH Dordrecht, The Netherlands

Printed on acid-free paper

All Rights Reserved © 1996 Kluwer Academic Publishers Softcover reprint of the hardcover 1 st edition 1996 No part of the material protected by this copyright notice may be reproduced in any form or by any means, electronic or mechanical, including photocopying, recording or by any other information storage and retrieval system, without written permission. from the copyright owner.

Table of Contents

List of contributors Xlll

Part 1: Epidemiology

1. Epidemiology of cancer in transplant patients 3 1. Penn

2. Multicenter analysis ofposttransplant malignancies 17 G. Opelz, V. Schwarz, H. Grayson, R. Henderson, R. Schnobel, r Wujciak and A. Ruhenstroth

3. German multicenter analysis of malignancies following renal replacement therapy in children 25 A.M Wingen

4. Malignancies transmitted with the transplant 31 N Lefrancois, A.-C Marrast, 1.-L. Garnier, 1.-M Dubernard and 1.-L. Touraine

Part 2: Malignancies preexisting to transplantation

5. Outcome of preexisting urological tumors in dialysis and in renal transplant recipients 41 G. Karam and B. Barrou

6. Screening for breast and gynecologic carcinomas in transplant patients 47 P Mathevet

7. Results of renal transplantation for Wilms' tumour 53 MF. Gagnadoux, D. Beurton, D. Jan, Y. Revillon, C Fekete, C Loirat, 1.-B. Palcoux, 1. Bedrossian, D. Durand, 1.-M Zucker, 1. Lemerle and M Broyer

Vl Table oj Contents

8. Prevention of recurrence after liver transplantation for hepatocellular carcinoma 57 H Bismuth, R. Adam, D. Castaing, L. Chiche and 1.s. Raccuia

Part 3: De novo malignancies after transplantation

9. Skin cancers in organ transplant recipients 65 S. Euvrard, 1. Kanitakis, C. Pouteil-Noble, Y. Chardonnet, G. Dureau, 1.-L. Touraine, D. Schmitt, M Faure, A. Claudy and 1. Thivolet

10. Kaposi's sarcoma in organ transplantation 73 J.L. Touraine, P Raffaele, 1. Traeger, 1.-L. Garnier, N Lejram;ois, C. Pouteil-Noble, A.-C. Marrast, S. Daoud and S. Euvrard

11. Human T-cell leukemia virus type I (HTLV-l) and transplantation 81 A. Bazarbachi and A. Gessain

12. Hepatitis B virus and primary liver cancer in Hepatitis B surface antigen positive and negative patients 89 P Paterlini and C. Brechot

13. Malignancies in patients with pancreas and kidney transplants 115 D. Cantarovich, J Dantal and J.P Soulillou

Part 4: Immunosuppression and cancer

14. Cancer risk factors in transplantation 123 E. Alamartine, N Diab, J.-P de Filippis and F Berthoux

15. Risk of cancer in transplant patients treated with recombinant growth hormone 131 P Cochat, M-H Saia, C. Lesage, C. Gouffrant and P Berlier

16. Malignancies in transplant patients under cyclosporine treatment for more than 10 years 13 5 U. Frei, V. Kliehm, M Kolditz, M Behrend and R. Brunkhorst

17. Risk of malignancies in patients treated with Sandimmun® for autoimmune diseases 141 V. Lamarque, C. Monka, M C. Commare and P Krupp

Table of Contents Vll

18. De novo malignancies following renal transplantation 149 N Yoshimura and T. Oka

Part 5: Epstein-Barr virus related malignancies

19. Virus induced cancer: The lesson of Epstein-Barr virus 161 MG. Masucci, V. Levitsky, T. Frisan, J Levistkaya and P.o. de Campos-Lima

20. Nonlymphoid Epstein-Barr virus induced neoplasms after organ transplantation 177 P.S. Dickman

21. The Epstein-Barr virus latency and reactivation 189 A. Sergeant

22. Early detection ofEBV infection and meaning in transplant patients 201 E.B. Drouet, C. Chapuis-Cellier, JL. Garnier and JL. Touraine

23. Lymphomas in the scidlhu mice: Effect ofEBV on human B-cells in vivo 209 JL. Garnier, N Blanc-Brunat, D. Laurin, G. Vivier, JL. Touraine, A. Sergeant, E. Drouet, MJ Glennie and G. T. Stevenson

Part 6: Lymphoproliferative syndromes after transplantation

24. Types of lymphomas in transplant and other immunosuppressed patients 217 M Raphael, S. Camillero-Broet, F Davi, A. Martin, S. Prevot and J Feuillard

25. Production and role of cytokines in lymphoproliferations of immune deficiency 223 D. Emilie

26. Interleukin 10 and non Hodgkin's lymphomas 229 N VoorzangerandJ-Y. Blay

27. Serum monoclonal immunoglobulins in renal transplant recipients: A study using high resolution electrophoresis and western blotting 243 G. Touchard, T. Pasdeloup, T. Hauet, M. Bauwens, G. Dumont, P. Aucouturier and J-L. Preud 'homme

Vlll Table of Contents

28. Increased risk oflymphoproliferative disorders following the use ofOKT3: Association with cumulative dose 249 L.1. Swinnen

29. Clinical characteristics of lymphoproliferations after renal transplantation. Nantes experience 259 1. Dantal, A. Moreau, M. Hourmant, D. Cantarovich, M Giral-Classe, G. Blancho, F. Buzelin, F. Gaillard and 1.p. Soulillou

30. Therapeutic issues in lymphoproliferative disorders: Treatment and outcome of 28 cases observed in a single center 267 V. Leblond, R. Dorent, M-o. Bitker, C. Soussain, D. Samuel, 1.L. Binet and M Raphael

31. Anti-B-cell MAb therapy of transplant-related lympho-proliferative disease 279 A. Durandy. M Benkerron and A. Fischer

32. Antibody treatment oflymphoma: Experience and prospects 289 G. T. Stevenson, M.J. Glennie and T.1. Hamblin

33. Idiotypic vaccination against low grade follicular B cell lymphoma 299 1. Brissinck, 1. Zhang, M Shaw, F. Stevenson, R. Hawkins and S. Russell

Part 7: Conclusion

34. Immunosurveillance revisited 1.-L. Touraine

Part 8: Posters

LYMPHOPROLIFERATIVE SYNDROMES

Circulating plasmacytoid cells: an early marker of post-transplant

307

lymphoproliferative disorders 315 R. Cahen, P. Felman, F. Berger, P. Trolliet, D. Morel, 1. Pages, H.1. Delecluze and M Labeeuw

Lymphoproliferative disease in heart transplant patients 316 C. Dufay, C. Besson, A. Pol, 1. Saez De Ibarra, A. Prat and H. Warembourg

Table of Contents IX

Successful multi-modality therapy of monoclonallympho proliferative disease in a lung transplant recipient 317 A. End, D. Kandioler, M Grimm, G. Dekan, K. Geissler, M Vogl, G. Mitterbauer, H Pirc-Danoewinata, W Klepetko

Lymphoproliferative disease localized in the renal allograft. French multicentric study 318 E. Renoult and M Kessler

SKIN CANCERS

Prevention of skin cancer during acitretin therapy in renal-transplant recipients: a placebo-controlled study 321 1.N Bouwes Bavinck, L.M Tieben, F.1. van der Woude, A.M Tegzess, 1. Hermans and B.J. Vermeer

Skin cancer after renal transplantation: efficacy of immunosupressive monotherapy on relapse rate 322 B. Branger, M. Dandurand and S. Abou

Dermatological lesions in kidney graft recipients 323 L. Coli, G. Pellerano, M Brunet, M Turin, L. Jost and F. Stengel

Skin cancers and precancerous lesions in renal grafts 324 M Messina, G.P Segoloni, D. Damiani, C. Angelini, F. Giacchino, M Bertero, P Stratta and A. Vercellone

OTHER MALIGNANCIES

De novo malignancies after kidney transplantation 327 F. Alfoldy, A. T6th, 1. Jaray, D. Gorog, P Borka, H Podder and F. Perner

Neoplastic diseases after liver transplantation 328 N Bourgeois, V. Lefebvre, 1. Van de Stadt, M Gelin, M-o. Peny, C. Deprez, T. Velu and M Adler

De novo carcinoma after liver transplant 329 T. Casanovas Taltavull, C. Baliellas, M Sanchez Gili, A. Casanova, C. Benasco, 1. Fabregat, A. Rafecas, 1. Figueras, S. Gil-Vernet, E. Jaurrieta and L.A. Casais

x Table of Contents

Primary bronchogenic carcinoma in transplant recipient 330 F Delcambre, P Rasmon, C. Noel, A. Pol, N Declerck, B. Gosselin, A. Wurtz, 1.1. Laffite, M Dracon and FR. Pruvot

Misdiagnosed malignancy in transplanted organs 331 0. Detry, B Detroz, M D'Silva, 1. 0. Defraigne, M Meurisse, P Honore, R. Limet and N Jacquet

Nephrogenic adenoma of the bladder in renal transplanted patients 332 P Guermani, M Pigato and M Manzo

Transmission of renal carcinomas with cadaveric donor kidneys: a five year follow up 333 P Guermani, F Alladio and M Manzo

Tumors after renal transplantation 334 M. Haberal, H. Karakayalz, E. Velidedeoglu, G. Arslan, H. Akk09, N BuyukpamukfU and N Bilgin

The incidence of malignancy in the population of 1280 kidney transplantations - A complete single center analysis 335 D. Igna, H. Keller and G. Kirste

The malignancies after kidney transplantation in Thailand 336 S. Jirasiritham

Kaposi's sarcoma in kidney transplant recipients 337 A. Toth, F AljOldy, 1. Jaray, D. Gorog, P Borka, I. Fehervari and F Perner

Malignancy in kidney transplant patients 338 V. Tfeska, 1. Valenta and E. Vesela

De novo malignancy following orthotopic liver transplantation for alcoholic cirrhosis 339 C. Vanlemmens, E. Monnet, S. Bresson-Hadni, M C. Becker, A. Minello, B. Heyd, G. Mantion, B. Kantelip, P Hillon and 1.P Miguet

MISCELLANEOUS

Sequential assessment of peripheral B-cells and detection of viral infections in kidney recipients 343 M C. Bene, E. Renoult, MN Kolopp-Sarda, S. Mattei, 1.P Villemot, M Kessler and G.c. Faure

Table of Contents Xl

HCV chronic infection in HD candidates to KT, influence on virus C genotypes on response to IFN treatment 344 T. Casanovas Taltavull, C. Baliellas, A. Pere1l6, X Cervantes, C. Benasco, E. Andres, M T. Gonzalez, S. Gil-Vernet, 1.L. Perez, 1. NiubO, A. Casanova and L.A. Cassis

Essential fatty acid deficiency in children with extrahepatic biliary atresia: influence of orthotopic liver transplantation 345 M. Chambon, A. Lachaux, A. Lapillonne, V. Chirouze, 0. Boillot, V. Fournier, M Lievre, D. Gille and M Hermier

Gammapathies in transplanted children: 18 month follow-up of 39 patients by quarterly immunofixation 346 PH. Desprez, A. Lahlou, ML. Wiesel, M Fischbach, U. Simeoni and 1. Geisert

Unusual infections after pulmonary transplantation 347 B. Etienne, H. Levrey, M Bertocchi, M Rabodonirina, M Celard, 1. Etienne, F. Vandenesh, MA. Piens, S. Paulus, 0. Bastien and 1.F. Mornex

Transient hyperphosphatasemia after liver transplantation in infancy 348 A. Lachaux, M Chambon, 0. Boilloit, C. Le Gall, I Loras, I Can terin 0,

1.M Pouillaude, D. Gille, L. David and M Hermier

Gilbert's syndrome. A possible cause of hyperbilirubinemia after orthotopic liver transplantation 349 A. Lachaux, A. Aboufadel, M Chambon, 0. Boil/at, C. Le Gall, D. Gille and M Hermier

Disseminated tuberculosis with pulmonary miliary and pharyngeal localisation in two kidney transplanted patients 350 A. C. Marrast, S. Daoud, 1.L. Garnier, N. Lefranr;ois, P Muller, F. Philit, 1.M Dubernard and J.L. Touraine

Succesful fibrinolysis following thrombosis in a grafted kidney artery 351 A. C. Marrast, 0. Rouviere, N. Lefranr;ois, M Dawhara, 1.L. Garnier, S. Daoud, 1.M Ramackers, D. Lyonnet, X Martin and 1.L. Touraine

xu Table of Contents

Atypical urinary citology in kidney transplant recipients 352 C. Massara, B. Basolo, L. Funaro, F. Bayle, A. De Marchi, M Formica, P. Guermani, C. Rollino, G.P. Segoloni, S. Coverlizza and G. Piccoli

Interest of radionuc1ide imaging in diagnosis of a case of non evident urinary fistula after renal transplantation 353 J.M Ramackers, C. N'Guyen, N. Lefram;ois, M Dawhara, A. C. Marrast, X Martin, J.L. Touraine, JM Dubernard and J O. Peyrin

Disconinuation of immunosuppressive treatment after kidney transplantation 354 S. Daoud, JL. Garnier, N. Lefram;ois, A.C. Marrast and J.-L. Touraine

Name Index 355

Contributors

E. ALAMARTINE Hopital Nord Avenue Albert Raimond 42277 St Priest en Jarrest France

A. BAZARBACHI Hotel Dieu Servo d'Hematologie 1, Place Parvis de Notre Dame 75004 Paris France

H.BISMVTH Centre Hepato-biliaire Hopital Paul Brousse 14, Av Paul Vaillant Couturier 94800 Villejuif France

JY.BLAY Centre Leon Berard 28, Rue Laennec 69373 Lyon 8 France

C.BRECHOT Carcinogenese Hepatique et Virologie Moleculaire- INSERM U 370 CHUNecker 156, rue de Vaugirard 75730 Paris 15 France

1. BRlSSINCK East Anglian Blood Transfusion Centre Long Road Cambridge CB 2 2PT UK

D. CANTAROVICH CHRU Hotel Dieu Nephrologie Place Alexis Ricordeau BP 1005 44000 Nantes France

P. COCHAT Hopital Edouard Herriot Pavillon S - Nephrologie 5, place d'Arsonval 69437, Lyon France

1. DANTAL CHU Hotel Dieu Nephrologie Place Alexis Ricordeau BP 1005 44035 Nantes France

1. DICKMAN Children's Hospital of Pittsburgh Dept. of Pathology 3705 Fifth Avenue PA 15213, Pittsburgh USA

E.DROUET Faculte de Pharmacie de Grenoble Domaine de la Merci 38706 La Tronche France

J.L. Touraine et al. (eds.), Cancer in Transplantation. Prevention and Treatment, xiii-xv.

XIV Contributors

A. DURANDY Hopital Necker Enfants Malades INSERMU 429 PavilIon Kirmisson 149, rue de Sevres 75743 Paris France

D.EMILIE Unite INSERM 131 32, rue des Camets 92140 Clamart France

S.EUVRARD Hopital Edouard Herriot Dermatologie Place d' Arsonval 69437 d'Arsonval 69437 Lyon France

U. FREI Standort Wedding Universitatsklinikum RudolfVirchow Postfach 65 02 69 13353 Berlin Allemagne

M. F. GAGNADOUX Hopital Necker - Enfants Ma1ades Nephro1ogie - Pediatrie 149, rue de Sevres 75743 Paris CEDEX 15 France

lL. GARNIER Hopital Edouard Herriot PavilIon P 5, Place d' Arsonval 69437 Lyon France

G.KARAM Hopital Hotel Dieu Clinique Urologique Place Alexis Ricordeau 44035 Nantes France

V. LAMARQUE Laboratoires Sandoz 14, Bd Richelieu 92500 Rueil Malmaison France

V. LEBLOND Hopital Pitie Salpetriere 41, Bd de 1 'hopital 75103 Paris France

N. LEFRANCOIS Hopital Edouard Herriot 5, Place d' Arsonval PavilIon P 69437 Lyon France

M.MASUCCI Karolinska Institutet Box 280 Microbiology and Tumor Biology Center S 17177 Stockholm Sweden

P.MATHEVET Hopital Edouard Herriot 5, Place d' Arsonval Gyneco1ogie Obstetique 69437NLyon France

G.OPELZ Abteilung Transplantations Immunologie Institut fUr Immunologie 1m Neuenheimer Feld 305 69120 Heidelberg Germany

P. PATERLINI Carcinogenese Hepatique et Virologie Moleculaire - INSERM U 370 CHUNecker 156, rue de Vaugirard 75730 Paris 15 France

LPENN Department of Surgery University of Cincinnati Medical Center 231 Bethesda Avenue Cincinnati OH 45267-0558 USA

M.RAPHAEL Service d'Hematologie Biologique H6pital d'Avicenne 125, route de Stalingrad 93009 Bobigny France

D. SAMUEL Centre Hepato Biliaire H6pital Paul Brousse 12, Avenue Paul Vaillant Couturier 94804 Villejuif FRANCE

A. SERGEANT H6pital Necker - Enfants Malades INSERMU 412 46, Allee d'Italie 69364 Lyon 7 France

T. STEVENSON Tenovus Research Laboratory General Hospital Tremona Road Southampton S09 4XY UK

J. SWINNEN Loyola University Medical Center Section of hematology Ion co logy Building 54 - 21605 First Avenue Maywood, Illinois 60153 USA

G. TOUCHARD Service de Nephrologie-Reanimation CHU Poitiers 350, Avenue Jacques Coeur - BP 577 86021 Poitiers France

Contributors xv

lL. TOURAINE H6pital Edouard Herriot Pavillon P 5, Place d'Arsonval 69437 Lyon 3 France

N. VOORZANGER Centre Leon Berard 28, Rue Laennec 69373 Lyon 8 France

A.M. WINGEN Universitatsklinikum Essen Hufelandstr. 55 45122 Essen 1 Germany

N. YOSHIMURA The Second Dept. of Surgery Kyoto Prefectural University 465 Kajii-cho Hirokoji, Kawaramachi Kamikyo-ku 602 Kyoto City Japan