canadian asset map for stem cell and regenerative medicine · canadian asset map for stem cell and...

Canadian asset Map for steM Cell and regenerative MediCineThis publication is also available online in HTML and .pdf formats at www.ic.gc.ca/stemcells

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note to readers: This study was completed in March 2011, and the majority of the research was conducted between December 2010 and January 2011. The data and information contained in this report are believed to be reliable and accurate as of December 2010 to January 2011 but are not guaranteed for completeness or accuracy.

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1 EXECUTIVE SUMMARY 2

2 INTRODUCTION 4 2.1 Importance of Regenerative Medicine and Stem Cells 4 2.2 Purpose of the Asset Map 4 2.3 Description of Stem Cells 5

3 OVERVIEW OF STEM CELL AND REGENERATIVE MEDICINE RESEARCH IN CANADA 7 3.1 Canada’s Global Position in Stem Cell and Regenerative Medicine Research 7 3.2 Funding for Stem Cell and Regenerative Medicine Research 8 3.3 Stem Cell and Regenerative Medicine Research Centres 9 3.4 Funding and Researchers by University and Province 9

4 FOCUS OF STEM CELL AND TISSUE ENGINEERING RESEARCHERS 13 4.1 Pluripotent Stem Cells 13 4.2 Tissue-Specific Stem Cells (Somatic) 14 4.3 Cancer Stem Cells 15 4.4 Tissue Engineering 15

5 DISEASES/CONDITIONS TARGETED BY STEM CELL AND REGENERATIVEMEDICINE RESEARCHERS 19

5.1 Cancer 19 5.2 Neurology 19 5.3 Musculoskeletal 20 5.4 Cardiovascular 20 5.5 Metabolic Including Diabetes 20 5.6 Hematological 21 5.7 Other 21 5.8 Translational Medicine 21

6 RELEVANT SUPPORT FACILITIES 25 6.1 Biobanks 25 6.2 Other Relevant Facilities 25

7 NETWORKS 31 7.1 National and International Networks 31 7.2 Provincial Networks 31

8 KEY RESEARCHERS AND INSTITUTIONS 37 8.1 Key Researchers 37 8.2 Key Research Institutions 39

9 CONCLUSION 46

10 ACKNOWLEDGEMENTS 46

11 CONTACTS 47

TABLE OF CONTENTS

iv

CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINETABLE OF CONTENTS

appendiX 48 Appendix 1

Methodology 48

Appendix 2 Interviewees 51

Appendix 3 Lists of Canadian Stem Cells and Regenerative Medicine Researchers 52

3a. Researchers in Alphabetical Order 52 3b. Researchers According to Regenerative Medicine Focus 96 3c. Researchers According to Disease Focus 117 3d. Examples of Researchers Working in Translational Medicine and/or

Clinical Trials 135

Appendix 4 Research Centres Listed by Province 137

Appendix 5References and Notes 141

Prepared by International BioPharma Solutions Ltd.For the Life Science Industries Branch of Industry Canada

Canadian asset Mapfor steM Cell and regenerative MediCine

2

CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

• Regenerative medicine, particularly stem cells, has considerable potential to help in the treatment of numerous common and intractable diseases and conditions

• Canada is a leader in stem cell research as these cells were fi rst discovered by Canadian scientists; however, other countries have become more and more important in this fi eld

• 68 centres within or affi liated with 25 of Canada’s universities are associated with stem cell and regenerative medicine research

• From the sources available for this Asset Map (mainly federal government), more than $277.5 million was spent on stem cell and regenerative medicine research over the last fi ve years (2006/7–2010/11), with Canadian Institutes of Health Research (CIHR) and Canada Foundation for Innovation (CFI) as the largest funders (providing 36% and 23% of funds, respectively); since the data from these sources perhaps account for only 50%–60% of overall funding, approximately $460 million–$560 million were probably spent on stem cell/regenerative medicine research

• Th e majority (65%) of funding went to Ontario (ON), particularly the University of Toronto and the University of Ottawa; Québec (QC) received 15%, followed by British Columbia (BC) and Alberta (AB)

(9% each)• 416 researchers (in professor, associate

professor, or similar positions) were identifi ed as working in the fi eld of stem cells and regenerative medicine research; 47% of these are located in Ontario, 25% in Quebec, 13% in British Columbia and 9% in Alberta

• In terms of universities, the University of Toronto (or its affi liated institutions) houses by far the greatest number of researchers (26%), followed by the University of British Columbia (UBC) (12%), the University of Ottawa, McGill University, and Université de Montréal

• Many of the 416 researchers are extremely well regarded, with 81 endowed Chairholders, 69 of whom are Canada Research Chairs (CRCs); 20 researchers have made signifi cant contributions to stem cell research and/or are particularly well funded and/or cited

• Th e most important research organizations within or affi liated with the universities in terms of numbers of stem cell and regenerative medicine researchers and endowed Chairs are with the University of Toronto (Ontario Cancer Institute, Sick Kids, McEwen Centre, Sunnybrook), the University of British Columbia (Terry Fox Laboratory), Université Laval (Laboratoire d’organogénèse expérimentale—LOEX),

eXeCutive suMMarY

3

EXECUTIVE SUMMARY 1and the University of Ottawa (Sprott Centre)

• 73% of researchers work with stem cells of some type, while 19% work in tissue engineering; others work in social sciences & humanities, bioprocessing, or various stem cell technologies such as high throughput sorting/analysis or cryopreservation

• Within the stem cell research area, 54% of researchers work with tissue-specifi c stem cells, 16% with pluripotent stem cells and 10% with cancer stem cells; another 10% work with a number of stem cell types, with the majority working with both tissue-specifi c and pluripotent

• Of the researchers who only work with tissue-specifi c stem cells, 36% work with hematopoietic, 19% with bone marrow/ mesenchymal and 14% with neural cells

• Of those who work with pluripotent stem cells, 92% work with embryonic and 20% with induced pluripotent stem cells (some researchers work with both types of pluripotent stem cells)

• Within the tissue engineering fi eld, at least 65% work with both scaff olds and cells, while 27% work just with biomaterials; the focus of the other researchers was unspecifi ed

• In terms of disease focus, 25% work in two or more disease areas, 24% work just on cancer, and 14% on neurological, 12% on musculoskeletal, and 10% on cardiovascular conditions

• Perhaps 100 researchers (24%) are involved in the translation of stem cell research from the laboratory to the clinic, with the Stem Cell Network (SCN) so far devoting approximately $50 million to the funding of translational projects over the past 10 years

• Canada has at least 4 public or university cord blood banks, 2 stem cell line banks, and 15 other relevant tissue banks that can be accessed by its regenerative medicine researchers; it also has at least 3 stem cell bioprocessing/manufacturing facilities as well as other relevant shared infrastructure

• Canada’s stem cell and regenerative medicine researchers are members of at least 5 international, 6 national, and numerous provincial relevant networks

• Overall, Canada remains among the world leaders in stem cell research.

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introduCtion2.1 Importance of Regenerative Medicine and Stem Cell Regenerative medicine involves the renewal of body tissues or the restoration of organ and tissue function through the use of living cells, particularly stem cells. Stem cells off er a particularly rich source of regenerative technologies as, under the right conditions, they can diff erentiate into many diff erent cell types (see below). Th ey have considerable potential to help in the treatment of numerous common and intractable diseases and conditions, such as diabetes, arthritis, stroke, renal failure, heart failure, cancer, spinal cord injury, and neurodegenerative diseases, including Parkinson’s and Alzheimer’s. Th ey can also be used in organ regeneration, genetic diseases, and other tissue repair or replacement (e.g., bone and skin transplants, cartilage regeneration).

A number of stem cell-based regenerative technologies are used today, such as eye surface stem cells for the treatment of some corneal diseases and injuries; and blood stem cells for treating hematological cancers (e.g. leukemias) and other conditions, such as sickle cell anemia. In fact, bone marrow transplants have become a standard of care for the treatment of certain hematological cancers, while skin stem cells are frequently used

in wound healing. However, these clinical uses represent just a small fraction of the opportunities in regenerative medicine and researchers are working furiously to understand the role stem cells may play in other diseases, and to translate these findings into the clinic.

To be clinically effective, stem cells need to be delivered to and integrate with the relevant body site. Delivery methods can include gels, films, scaffolds, and targeted carrier technologies that are produced from biomaterials (e.g., polymers, lipids), modified cells or, in the case of some carrier technologies, modified viruses. The combination of stem cells (or other cell types) and a scaffold or similar technology is called tissue engineering. Furthermore, because stem cells occur in highly limited quantities within the body, effective methods are required to mobilize, isolate, culture, and store them. Adequate production methods are essential to unlocking their clinical potential.

2.2 Purpose of the Asset MapUsing the methodology described in Appendix 1, this Asset Map provides a snapshot of Canadian stem cell and regenerative medicine research. Since this research sector could potentially be extremely broad-based, we have specifi cally


55

focused on pluripotent, tissue-specifi c, and cancer stem cell research, biomaterials in terms of scaff olds or similar technologies for use in regenerative medicine, and tissue engineering in terms of production of stem cells and their delivery device. We have not included gene therapy (unless it involves stem cells) or growth factors, xeno-organs, regeneration of plants or animals (unless the studies relate to experimental models of human conditions) or companies working in regenerative medicine.

2.3 Description of Stem CellsTh is Asset Map distinguishes between three overall types of stem cell. Th e two major stem cell types are pluripotent and tissue-specifi c (also known as adult or stromal). Th e third type of stem cell specifi cally targeted in this report are cancer stem cells, a type of tissue-specifi c cell.

Pluripotent stem cells have the ability to give rise to all kinds of cell in the body, such as those of the heart, lungs, muscles, skeleton, or brain. Th ese unspecialized stem cells are derived from either embryos or from adult stem cells that have been reprogrammed (or “induced”) to enter an embryonic stem cell–like state. Th e latter are called induced pluripotent stem cells.

Tissue-specific stem cells have been identifi ed in many organs and tissues, including brain, bone marrow, peripheral blood, blood vessels, skeletal muscle, skin, teeth, heart, gut, liver, ovarian epithelium, and testis. Th ey are undiff erentiated cells that are able to self renew and diff erentiate. Since their primary role in a living organism is to maintain and repair the tissue in which they are found, their

capacity for diff erentiation is usually limited to cell types in the organ of origin.1 So, for example, neural stem cells can become any type of cell in the brain or spinal cord but cannot diff erentiate into heart cells unless they have been reprogrammed into induced pluripotent stem cells.

Cancer stem cells (also known as tumor-initiating cells) are a resilient subset of cells found in tumors with the capacity to self-renew and diff erentiate. Th ey’ve been identifi ed in many types of solid tumor cancers, including cancer of the breast, head and neck, lung, prostate, pancreas and glioblastoma. Cancer stem cells appear to be preferentially resistant to both standard chemotherapy and radiotherapy. Although cancer stem cells are not part of regenerative medicine (they regenerate cancer tissues thereby destroying normal tissues), they are an important aspect of stem cell research.

2INTRODUCTION

inside3.1 Canada’s Global Position in Stem Cell and Regenerative Medicine Research3.2 Funding for Stem Cell and Regenerative Medicine Research3.3 Stem Cell and Regenerative Medicine Research Centres3.4 Funding and Researchers by University and Province

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overvieW of steM Cell and regenerative MediCine researCH in Canada3.1 Canada’s Global Position in Stem Cell and Regenerative Medicine ResearchCanada has been a leader in the stem cell research fi eld since Canadian researchers Drs. James Till and Ernest McCulloch of the Princess Margaret Hospital/Ontario Cancer Institute in Toronto fi rst proved the existence of stem cells (hematopoietic) almost 50 years ago.2 For this achievement, they were awarded the 2005 Lasker Prize (oft en described as America’s “Nobel”).3

Th eir work has contributed to the development of several lifesaving therapies, such as bone-marrow transplantation to treat cancer. In fact, more than 42,000 people worldwide have been treated using blood stem cells to renew their blood supply.4 Furthermore, through the continued training of researchers in their and their former students’ labs, Canada has continued to make signifi cant contributions in this area:5

• Drs. Janet Rossant and Andras Nagy fi rst proved the inherent pluripotential nature of an embryonic stem cell

• Dr. John Dick discovered cancer stem cells

• Dr. Sam Weiss was the fi rst to identify neural stem cells in the brain

• Dr. Connie Eaves discovered breast stem cells

• Dr. Michael Rudnicki identifi ed muscle and cardiac stem cells6

• Dr. Freda Miller demonstrated the existence of stem cells in adult skin tissue

• Dr. Derek van der Kooy identifi ed retinal stem cells

• Dr. Mick Bhatia developed a process to transform skin cells into stem cells.7

In fact, Canada’s importance in hematopoietic stem cell research up until at least 2000 was illustrated by a Nature Immunology review that found 15 of the 32 most important papers in the fi eld over the

8


period from 1960–2000 were authored by Canadians.8 In the fi eld of embryonic stem cell research, Canada ranked second in the number of publications from 1991–2001, and fi rst in both total citations and citations per paper.9

However, in recent years Canada has been slipping in importance, mainly because of a slowdown in comparative research funding. Th us, according to the MaRS Regenerative Medicine 2009 Industry Briefi ng report,10 in 2009 Canada occupied 4th position in the global rankings of stem cell researching countries aft er the United States (US), United Kingdom (UK), and South Korea in terms of government funding and 3rd in terms of infl uential stem cell patents (aft er the US and UK), although it still had a leading position (1st) in terms of citations. Although the South Korean investments mentioned above have probably declined recently following the bogus cloning research results of Hwang, other governments (e.g., Germany, the EU) and US states have been making signifi cant and growing investments (Drew Lyall [Executive Director, SCN], personal communication). Th us, since 2007, individual US states other than California have promised over $1 billion in stem cell research funding, generally over a 10 year period (e.g., Connecticut $100 million, New Jersey $250 million and New York $600 million),11 while Wisconsin has established a $750 million public-private partnership for such research.12 California alone is investing $3 billion in the full spectrum of stem cell research and therapeutic development, from fundamental research to manufacturing facilities to clinical trials and beyond.13

3.2 Funding for Stem Cell and Regenerative Medicine ResearchTh e majority of funding information was obtained from federal government sources. Funding information was also available on the Terry Fox Foundation (TFF), US National Institutes of Health (NIH), AllerGen, the Ontario Government, and the Saskatchewan Health Research Foundation websites. Dollar fi gures were not provided on the websites of other provincial governments. Although the SCN breaks down its funds for individual research projects, only total NCE funding for the Network was used in the analysis (see Appendix 1 Methodology).

A minimum of $277.5 million from the aforementioned sources was spent on stem cell and regenerative medicine research over the last fi ve years (2006/7–2010/11). As illustrated in Figure 1, CIHR was the largest funder, providing 36% of the funds. Th e NCE funds, at 10% of the total, were those dedicated to the SCN.

Based on the data contained in the BC Regenerative Medicine Asset Map, the aforementioned funders included in this analysis probably account for only 50%–60% of funding in stem cell and biomaterials research for regenerative medicine. Th us, over the last fi ve years, approximately $460 million – $560 million were probably spent on research into these fi elds. Information contained on the websites of various researchers indicates that other funders include:

• ALS Society of Canada• Canadian Cancer Society• Canadian Breast Cancer Foundation• Christopher Reeve Foundation (US)• Heart and Stroke Foundation (of Canada

and Ontario)

9

3OVERVIEW OF STEM CELL AND REGENERATIVE MEDICINE

RESEARCH IN CANADA

• Howard Hughes Medical Institute (US)• Juvenile Diabetes Research Foundation

(Canada and US/ International)• Muscular Dystrophy Association (Canada

and US)• National Cancer Institute of Canada• SickKids Foundation• US Muscular Dystrophy Association• Various companies (e.g., Roche

Foundation for Anemia Research; Bayer)

3.3 Stem Cell and Regenerative Medicine Research Centres As listed in Table 1, 25 of Canada’s universities are associated with stem cell and regenerative medicine research. If the

individual research institutes within or affi liated with these universities are also counted (see Appendix 4), then Canada has at least 68 centres where researchers are investigating stem cells and regenerative medicine. Information on the most important of these centres can be found in Section 8.

3.4 Funding and Researchers by University and ProvinceAs illustrated in Figure 2,14 65% of the $277.5 million in funding went to Ontario (ON). Québec (QC) received 15% followed by British Columbia (BC) and Alberta (AB) (9% each).

figure 1: Source of Funding for Stem Cell & Regenerative Medicine Research 2006/7 to 2010/11 ($277.5M)

* Other includes AllerGen, the Saskatchewan Health Research Foundation, and Insception Biosciences Inc.

1% Other*

2% Genome Canada

5% ON Govt

3% NIH (US)3% NSERC

8% CRC

9% TFF

10% NCE

23% CFI

36% CIHR

10


figure 3: University Funding Over $10M (2006/7 to 2010/11)

figure 2: Total Funding by Province 2006/7 to 2010/11 (Total $277.5M)

2% Other*

9% BC

15% QC

65% ON

9% AB

* Other includes MB, SK, NB, NS, NL.

provinCe universitY

BritisH ColuMBia (BC)

Simon Fraser U.

U. British Columbia

U. Victoria

alBerta (aB)

U. Alberta

U. Calgary

sasKatCHeWan (sK)

U. Saskatchewan

ManitoBa (MB)

U. Manitoba

ontario (on)

Carleton U.

McMaster U.

Queen’s U.

U. Guelph

U. Ottawa

U. Toronto

U. Waterloo

U. Western Ontario

York U.

QuÉBeC (QC)

École polytechnique de Montréal

McGill U.

U. Laval

U. Montréal

U. Québec à Montréal

U. Sherbrooke

nova sCotia (ns)

Dalhousie U.

neW BrunsWiCK (nB)

New Brunswick Heart Centre

neWfoundland & laBrador (nl)

Memorial U.

table 1. Canadian Universities Associated with Stem Cell and Regenerative Medicine Research

U.Alberta

McMasterU. McGill

U.

U. Toronto$117M

U. Ottawa$42.8M

U. Montreal$25.7M

UBC$23.2M

$14.4M$14M$9.7M

Associated with the fact that Ontario received the most funding, the University of Toronto received the lion’s share of funds between 2006/7 and 2010/11, at $117 million (Figure 314). All other universities received less than $50 million.

Using the defi nitions stated in section 2.2. and the Methodology (Appendix 1), 416 researchers (in professor, associate professor, or similar positions) were identifi ed as working in the fi eld of stem cells and regenerative medicine research. A list of them can be found in Appendix 3a. Although all these researchers have obtained grants for stem cell and related research and/or mention stem cell and related research on their websites, it should be noted that they oft en work in additional research areas and stem cells may not be their key focus.

A breakdown of the number of researchers working in each province and institution can be found in Appendix 4. Th e provincial spread of researchers is illustrated in Figure 4. Forty seven percent reside in Ontario, 25% in Quebec, 13% in British Columbia and 9% in AB. In terms of universities, the University of Toronto (or its affi liated institutions) houses by far the greatest number of researchers (26%), followed by the University of British Columbia (12%), the University of

Ottawa (8%), McGill University (8%), and Université de Montréal (8%) (Figure 5 and Appendix 4). Information on individual research institutions affi liated with these universities can be found in Section 8.

11

3

SK 5 NL 1 NB 1

ON195

QC102

BC53 AB

37

MB11

NS11

figure 4: Number of Researchers By Province

figure 5: Number of Researchers By University

OVERVIEW OF STEM CELL AND REGENERATIVE MEDICINE

RESEARCH IN CANADA

U. MontrealU. McGill

U. Laval23

UBC50

33 U.WesternOntario

17

U. Toronto110

U.Ottawa

34

19

32 U.Calgary

2116

U.Alberta

McMasterU.

inside4.1 Pluripotent Stem Cells4.2 Tissue-Specifi c Stem Cells (Somatic)4.3 Cancer Stem Cells4.4 Tissue Engineering

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foCus of steM Cell and tissue engineering researCHers Of the 416 researchers working in stem cell and regenerative medicine research, 303 (73%) work with stem cells of some type, while 79 (19%) work in tissue engineering (Figure 6). Th e others work in social sciences and humanities (n=16), bioprocessing (n=6), various stem cell technologies such as high throughput sorting/analysis or cryopreservation (n=9), or their regenerative medicine research focus was unspecifi ed (n=3).

Within the stem cell research area, the majority of researchers (54%, n=166) work with tissue-specific stem cells. Forty nine (16%) investigators work with pluripotent stem cells, while 30 work with cancer stem cells (10%). Another 29 (10%) work with a number of different stem cell types (“various”), with at least 17 working with both tissue-specific and pluripotent (Figure 7). The specific targets of many of these researchers can be found in Appendix 3b.

4.1 Pluripotent Stem CellsAs described previously, pluripotent stem cells consist of embryonic and induced pluripotent stem cells. Of the 49 researchers who work only with pluripotent stem cells, the majority focus on embryonic stem cells (84% exclusively, another 12% working with both types, i.e., 96% in total). Similarly with the 17 who work with both pluripotent and tissue-specifi c cells, 82% focus on embryonic stem cells (65% exclusively, another 17% working with both types). Th us, of all 66 researchers who work with pluripotent stem cells, whether or not exclusively, 92% work with embryonic stem cells. Twenty percent (n=13) of researchers working with pluripotent stem cells work with those that have been induced (four [6%] with induced pluripotent stem cells only, with or without tissue-specifi c cells; and nine [14%] with both types of pluripotent stem cells, again with or without tissue-specifi c cells) (Figure 8). Individual researchers working with each group of cells are listed in Appendix 3b.

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4.2 Tissue-Specifi c Stem Cells (Somatic)Th e majority of Canadian stem cell researchers work with tissue-specifi c cells. Th ese can take many diff erent forms as shown in Figure 9.

Of the 166 researchers who only work with tissue-specifi c stem cells, 58 (36%) work

with hematopoietic cells. Th e next most important stem cell types are bone marrow/ mesenchymal and neural cells. Bone marrow contains at least two kinds of stem cells: hematopoietic stem cells that form all types of blood cells and mesenchymal stem cells that can generate bone, cartilage, fat, cells that support the formation of blood, and fi brous connective tissue.15 In most

figure 6: Percentage of Researchers Working in Each Major Discipline (n=416)

4% Other

19% Tissue Engineering

73% Stem Cells

4% Social Sciences &Humanities

figure 7: Focus of Stem Cell Research (n=303)

10% Stem Cells: Unspecifi ed (n=29)

10% Stem Cells: Various (n=29)

10% Stem Cells: Cancer (n=30)

16% Stem Cells: Pluripotent (n=49)

54% Stem Cells: Tissue-Specifi c (n=166)

4FOCUS OF STEM CELL AND TISSUE ENGINEERING RESEARCHERS

figure 8: Focus of Pluripotent Stem Cell Researchers (n=66)

3% Induced Pluripotent & Tissue-Specifi c (n=2)

2% Unspecifi c Pluripotent & Tissue-Specifi c (n=1)

5% Both Pluripotent Types & Tissue-Specifi c (n=3)

3% Induced Pluripotent Only (n=2)

9% Both Pluripotent Types Only (n=6)

17% Embryonic & Tissue-Specifi c (n=11)

61% Embryonic Only (n=41)

cases where a researcher mentioned bone marrow stem cells, the kind of stem cell was not specifi ed. In regard to neural stem cells, these include stem cells derived from the brain, spinal cord, and eye. Th e category of “other” included the few researchers who were working with the stem cells listed at the end of Figure 9. Two of the researchers working with a number of (“various”) diff erent stem cell types also worked with these rarer stem types. Th e tissue-specifi c focus of individual researchers can be found in Appendix 3b.

4.3 Cancer Stem CellsAs indicated in Figure 7, 30 researchers are working with cancer stem cells. Among those researchers who are working with several diff erent stem cell types, one is also working with cancer stem cells. Cancer stem cells are an important group of rare cancer cells that have the ability to self-renew, thereby maintaining and growing cancerous tissue. A list of cancer stem cell researchers can be found in Appendix 3b.

4.4 Tissue EngineeringMany of those involved in tissue engineering work with both biomaterials and stem cells. However, some are just involved in developing the biomaterials, particularly scaff olds, that are required to deliver and/or integrate stem cells into a person’s body. Figure 10 gives a breakdown of the research focus of Canada’s 79 tissue engineers working in the fi eld of regenerative medicine that includes stem cells. At least 65% work with both scaff olds and cells, while 27% work just with biomaterials. Th e focus of each tissue engineering researcher can be found in Appendix 3b.

15

16


figure 9: Focus of Tissue-Specifi c Stem Cell Researchers (n=166)

4% Muscle (n=7)

3% Pancreas (n=5)

10% Unspecifi ed Adult (n=17)

14% Other (n=23)*

36% Hematopoietic, including cord blood (n=58)

14% Neutral, including retinal (n=24)

19% Bone Marrow/Mesenchymal (n=32)

*Other includes amniotic (n=1), cardiac (n=3), dermal (n=3), fat (n=4), fetal (n=2),

gastrointestinal (n=2), germline (n=3), lung (n=1), mammary (n=2 + a researcher who

worked with various cell types), ovary (n=1), vascular (n=1). Another researcher who

worked with various cell types worked with placental stem cells.

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figure 10: Focus of Tissue Engineering Researchers (n=79)

18% Biomaterials:Unspecifi ed (n=14)

65% Tissue Engineering:Stem Cells and Scaffolds (n=52)

9% Biomaterials:Scaffolds (n=7)

8% Tissue Engineering: Unspecifi ed(n=6)

4FOCUS OF STEM CELL AND TISSUE ENGINEERING RESEARCHERS

inside5.1 Cancer5.2 Neurology5.3 Musculoskeletal5.4 Cardiovascular5.5 Metabolic Including Diabetes5.6 Hematological5.7 Other5.8 Translational Medicine pH

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diseases/Conditions targeted BY steM Cell and regenerative MediCine researCHers Of the 416 researchers working in stem cell and regenerative medicine research, 16 are investigating social science and humanities aspects. Th ese individuals have been excluded from the disease analysis. Th us, the data in Figures 11 to 14 refer only to 400 researchers or a subset thereof. Th e disease focus of each researcher is shown in Appendices 3a and 3c.

As indicated in Figure 11, the highest number of researchers (n=101) work in two or more disease areas (designated “various”), such as hematological and cardiovascular, or neurological, urological, and cutaneous conditions. Th is is particularly true for those who focus on tissue engineering. Some of these individuals are referred to in the sub-sections below.

5.1 CancerTh e most common condition targeted by Canada’s researchers is cancer with 94 working in this area (Figure 11). In addition, two of the nine working in hematological diseases include cancer research, as do nine working in the “various” category. Th us, at least 105 (26%) investigators work in cancer research. As indicated in Figure 12, the most common focus of cancer research is hematological, particularly leukemia.

5.2 NeurologyTh e second most important disease focus is neurological. As well as the 56 individuals almost exclusively focused on such diseases, at least another 10 categorized in the “various” group also work in this area. Th e most common diseases being investigated by these 66 researchers (who constitute 17% of the 400 total number of researchers) are those of the eye, spinal cord, and multiple

20


sclerosis (Figure 13). “Other” conditions include ALS (n=2), Parkinson’s (n=2), Alzheimer’s (n=2), Rett’s syndrome (n=1), stroke (n=2), brain or unspecifi ed injury (n=3), neurological development (n=1), and olfactory (n=2).

5.3 MusculoskeletalFigure 11 indicates that 49 investigators are almost exclusively focused on musculoskeletal conditions, including bone, disc, ligament and cartilage formation and/or regeneration and muscular dystrophy. Th e targeted condition is not specifi ed or involves multiple aspects in 32 cases. An additional eight researchers in the “various” category also work on musculoskeletal conditions, bringing the total to 57 (14% of the 400 total).

5.4 CardiovascularOf the 41 researchers working almost exclusively in cardiovascular research, 23 (56%) are almost entirely focused on the heart. In addition, 16 of those working in several disease areas include cardiovascular conditions among their areas of focus. Th us at least 57 (14% of the 400 total) researchers are working on cardiovascular diseases.

5.5 Metabolic Including DiabetesAll 12 people working on metabolic diseases as shown in Figure 11 work on diabetes. In addition, five of the researchers in the “various” category also work on diabetes. Thus 17 (4% of the 400 total) investigators are using stem cells or related tissue engineering to address diabetes.

figure 11: Disease Focus of Stem Cell and Regenerative Medicine Researchers (n=400)

2% Hematological (n=9)

3% Metabolic (n=12)

25% Various (n=101)

10% Other (n=38)

10% Cardiovascular (n=41)

12% Musculoskeletal (n=49)

24% Cancer (n=94)

14% Neurological (n=56)

21

* Other includes one each of colorectal, liver, ovarian and prostate.

5DISEASES/CONDITIONS TARGETED BY STEM CELL AND REGENERATIVE

MEDICINE RESEARCHERS

5.6 HematologicalFigure 11 shows that nine researchers are working on hematological conditions other than cancer. In addition, fi ve of the researchers working in several disease areas are targeting hematological conditions. Table 2 shows a breakdown of the hematological focus of these 14 researchers.

5.7 OtherFigure 14 shows all other disease areas targeted by Canada’s stem cell and regenerative medicine researchers. Th ose receiving the most attention are immunological conditions (n=6), including

allergies, asthma, immunodefi ciency, and autoimmune. Five researchers are also working on better understanding embryogenesis, while eight researchers are working on aspects of male and female fertility (“reproduction”). Respiratory conditions, such as cystic fi brosis, or lung development or repair, are the focus of four researchers. All other conditions are targeted by three researchers or fewer.

5.8 Translational MedicineAlthough the constraints involved in the preparation of this report did not allow for a detailed analysis of researchers that are

note that in several cases, two neurological indications were given, hence the total of the bars is more than 66.

figure 12: Number of Researchers Working on Cancer (n=105)

figure 13: Number of Researchers Working on Neurological Conditions (n=66)

Brain

Not Specified52

Hematological37

6

Breast4

Cervix2

Other4

52

Multiple Sclerosis

Spinal Cord Injury

Eye

Other

Multiple/Not Specified

5

11

16

15

25

22

driving translational medicine (moving fi ndings from the laboratory to the clinic), many were noted during the analysis that did take place. Th irty nine of these are listed in Appendix 3d.

There is no doubt that many other researchers listed in Appendix 3a are also working to translate the basic stem cell research findings to the clinic, as the SCN indicated that its approximately 100 researchers had spent around $50 million on translational research over the past 10 years (Lyall, personal communication). Furthermore, Canada has a history of clinical innovations with stem cells. For example, clinicians at the University of Alberta published “The Edmonton Protocol” in the New England Journal of Medicine (2000), providing the first proof of principle that Type 1 Diabetes could be treated effectively by using replacement beta cells (in this case from donated pancreases).16 This innovation has spurred researchers to explore the potential of deriving functional beta cells from stem cells. In addition, Canadian clinicians developed the “Halifax Protocol” which is now being used in international clinical trials to treat Parkinson’s disease17. Our researchers are also developing new protocols for multiple sclerosis, graft-versus-host disease, stroke, pulmonary hypertension, neuroblastoma and other diseases that can be addressed with stem cells.

table 2. Number of Researchers Working Within the Hematological Disease Area (excluding Cancer)

tYpe of disease nuMBer of researCHers

Anemia 5

Hemophilia 4

Unspecifi ed 5


23

table 2. Number of Researchers Working Within the Hematological Disease Area (excluding Cancer)

tYpe of disease nuMBer of researCHers

Anemia 5

Hemophilia 4

Unspecifi ed 5

figure 14: Number of Researchers Working on “Other” Conditions (n=38)

5DISEASES/CONDITIONS TARGETED BY STEM CELL AND REGENERATIVE

MEDICINE RESEARCHERS

Aging

Cardiopulmonary

Cutaneous

Dental

Embryogenesis

Gastrointestinal

Genetic

Immunological

Infection

Renal

Reproduction—Female

Reproduction—Male

Respiratory

Urological

1

1

3

3

5

1

2

6

1

1

5

3

4

2

inside6.1 Biobanks6.2 Other Relevant Facilities

25

relevant support faCilities6.1 Biobanks6.1.1 CORD BLOOD BANKS Th ere are two public cord blood banks in Canada: one in Montréal (Héma-Québec Cord Blood Bank) and the other one in Edmonton (Alberta Cord Blood Bank). Th ere are also blood banks at several universities that have samples available for research purposes.18 Furthermore, there are private blood banks in which parents can place their baby’s blood in case of future medical problems. In addition, Canadian Blood Services are trying to establish a national cord blood bank that should be available by 2013.19 Th e blood banks listed in Table 3 are those that may be accessed for scientifi c purposes. It should be noted that this list may not be all-inclusive.

6.1.2 OTHER BIOBANKSOther biobanks include those with tissue samples (generally from cancer patients) or pluripotent stem cell lines (both embryonic and induced pluripotent) available for research purposes. Table 4 lists some of those available in Canada. Again, this list is probably not all-inclusive but includes two stem cell line banks and 15 other tissue banks. Other potential biobanks are in the planning stage, e.g., a brain tumour tissue bank in Vancouver.20

6.2 Other Relevant FacilitiesAs well as the biorepositiories, there are lots of other facilities that may be relevant to stem cell researchers. Th ese include at least three manufacturing/bioprocessing facilities as well as the other centres listed in Table 5.

26


Blood BanK Managed BY url

Alberta Cord Blood Bank U. Alberta www.acbb.ca

Banque publique de sang de cordon du Québec

Héma-Québec www.hema-quebec.qc.ca/donner/cellules-souches/don-de-sang-de-cordon-ombilical/index.fr.html

Registre des donneurs de cellules souches (moelle osseuse)

Héma-Québec www.hema-quebec.qc.ca/donner/cellules-souches/registre-des-donneurs/index.fr.html

Clinical-Research Cord Blood Bank of the McGill University Health Centre

McGill University Health Centre muhc.ca/research/page/core-facilities

Toronto Cord Blood Program Inseption Biosciences, Mount Sinai Hospital

www.insception.com

BioBanK loCation inforMation url

steM Cell lines

Braley Human Stem Cell Library (HSCL)

Stem Cell and Cancer Research Institute (SCC-RI), Hamilton, ON

Has more than 15 iPS cell lines for use in regenerative medicine research.

fhs.mcmaster.ca/SCCRI/21

National Registry for Human Embryonic Stem Cell Lines

Administered by CIHR22 A list of all human embryonic stem cell lines derived under the auspices of an Institution that receives Canadian Agency funds. Includes 4 cell lines (2 each in Toronto and Calgary).

www.cihr-irsc.gc.ca/e/39580.html

otHer BioBanKs

Brain Tumour Tissue Bank

Lawson Research Institute, London, ON

Collects and provides human brain tumour specimens and matching clinical data for neuro-oncology research in Canada and internationally.

www.lawsonresearch.com/clinical_research/brain_tumour_bank.htm

Breast Tumour Bank BC Cancer Research Centre, Vancouver, BC

This BC Cancer Agency’s breast cancer tumour tissue repository (BREAST-TTR) comprises several important banks of breast tissues, contemporaneous as well as archival.

molonc.bccrc.ca/?page_id=421

Canadian Breast Cancer Foundation (CBCF) Tumor Bank

Cross Cancer Institute, Edmonton; Tom Baker Cancer Centre, Calgary; U. of Calgary; all in AB

Collaboration between CBCF—Prairies/NWT Chapter and the Alberta Health Services, providing a comprehensive collection of cancer specimens with related clinical information for use by researchers.

www.abtumorbank.com

Canadian Virtual Brain Tumour Bank

Toronto Western Hospital, Toronto, ON Acts as a resource for researchers to provide them with information on the types of brain tumour tissue samples available and direct them to the tumour tissue banking sites holding these samples.

www.braintumourbank.ca

table 4. Other Biobanks Available to Researchers

table 3. Publicly-Available Cord Blood Banks

27

RELEVANT SUPPORT FACILITIES 6BioBanK loCation inforMation url

Manitoba Breast Tumor Bank

Cancer Care Manitoba, Winnipeg, MB Provides anonymized, processed, and annotated cancer tissues and data for translational research.

www.umanitoba.ca/institutes/manitoba_institute_cell_biology/MBTB/Index4.htm

Maritime Brain Tissue Bank

Dalhousie U., NS Collects brain tissues and makes them available for researchers who are trying to better understand the causes of dementia.

research.medicine.dal.ca/cores-brain.htm

National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) Tissue Bank

Queen’s U., Kingston, ON Contains unique disease specifi c collections, housed, catalogued, and linked to an associated clinical dataset to support correlative science.

www.ctg.queensu.ca/TissueBank/index.html

Ontario Tumour Bank Ontario Institute for Cancer Research, Toronto, ON

Focused on collection of tumour-related human biospecimens for use by academic and industry cancer researchers.

www.ontariotumourbank.ca

OvCaRe Gynaecologic Tissue Bank

Vancouver General Hospital and BC Cancer Agency, Vancouver, BC

Contains tumour and serum samples from over 1,100 consenting patients. In addition to providing research material for OvCaRe researchers, the Tumour Bank has contributed to 43 national and international research projects.

ovcare.ca/research/platforms.php

PROCURE Québec Prostate Cancer Biobank

Mont-Royal, QC Collects and stores standardized high volumes of prostatic tissues, blood, urine, clinical information and socio-demographic data from men undergoing prostate cancer screening and surgery across QC and facilitates access to these resources.

www.procure.ca/tiki-index.php?page=biobank_overview_introduction

Québec Leukemia Cell Bank

Centre de recherche de l’Hôpital Maisonneuve-Rosemont, Montréal, QC

Supports basic and clinical blood cancer research; provides an infrastructure and services aimed at facilitating the work of researchers in various fi elds, such as oncology, hematology and immunology.

www.bclq.org/en/index.html

Le Réseau de recherche sur le cancer du Fonds de la recherche en santé du Québec (RRCancer-FRSQ Network)

Montréal, QC Provides tumour banks and other resources to Québec researchers.

www.rrcancer.ca

Tumour Bank Sunnybrook Research Institute, Toronto, ON

Collects, stores, and distributes tissues for the following body sites: breast, prostate, colorectal, gynecological.

sunnybrook.ca/research/content/?page=sri_core_tbank_home

Tumour Tissue Repository

BC Cancer Agency, The Deeley Research Centre, Victoria, BC

Collects anonymized and appropriately consented biospecimens (tissues and blood) and associated clinical information for use by cancer translational researchers throughout Canada and worldwide.

www.bccrc.ca/dept/ttr

Vancouver Prostate Centre Biorepository

Vancouver Prostate Centre, Vancouver, BC

Contains over 2,000 prostate cancer specimens (both fresh frozen and paraffi n embedded), as well as an integrated database.

www.prostatecentre.com/our-research/core-facilities/biorepository

28

naMe desCription url

Biotechnology and Pharmaceutical Processes Research Unit, École polytechnique de Montréal, QC

Develops bioprocesses to produce and purify high quality, valuable biomolecules.

www.polymtl.ca/bio-p2/

Centre de Recherche de l’Hôpital Maisonneuve-Rosemont, Montreal, QC

As well as the Québec Leukemia Cell Bank described in Table 4 and the CECT described below, the Centre de Recherche de l’Hôpital Maisonneuve-Rosemont also offers other relevant research facilities such as fl ow cytometry and an animal supply facility.

recherche.maisonneuve-rosemont.org/en-ca/research/technical-support-programs/fl ow-cytometry.html

Centre for Applied Genomics (TCAG), Hospital for Sick Children (Sick Kids), MaRS Centre, Toronto, ON

Provides project support to investigators, including laboratory experimentation, statistical analysis and bioinformatics support. It also has a Biobanking and Databasing Facility that provides DNA extraction from lymphoblasts, fi broblasts and other cell types, archiving of white cell pellets, preparation and immortalization of cell lines, and comprehensive databasing and tracking of samples and/or cell lines within the facility.

www.tcag.ca

Centre of Excellence for Cellular Therapy (CECT), Centre de Recherche de l’Hôpital Maisonneuve-Rosemont, Montreal, QC

Opening in 2011, CECT will conduct leading-edge research on stem cells, the immune system and cancer; train young researchers; and bring together basic and clinical research. It will offer bioreactors, a high speed cell sorter, FACS analyzer, a level BSCL2 facility, and other state-of-the-art equipment.

recherche.maisonneuve-rosemont.org/en-ca/research/research-units/centre-of-excellence-for-cellular-therapy.html

LOEX (Experimental Organogenesis Laboratory—Laboratoire d’organogénèse expérimentale), U. Laval. QC

Works with epidermal culture and a self-assembly approach to tissue engineering. Activities cover four major areas: (1) Stem cells, differentiation and cellular interactions; (2) Cutaneous, cardiovascular, orthopedic, ophthalmologic, pulmonary and urinary tissue reconstruction; (3) Biological applications of reconstructed tissues (physiology, pathophysiology, pharmacology, toxicology, transplantation) and pre-clinical trials; (4) Clinical applications of cellular and tissue-based therapies.

www.cha.quebec.qc.ca/en/www/research/fi elds-of-research/tissue-engineering-and-regeneration/index.html; www.loex.qc.ca/recherche.interets.php?langue=2

Ottawa Hospital Research Institute (OHRI), Ottawa, ON

With 230,000 square feet of dedicated basic and clinical research space, the OHRI houses good manufacturing practice laboratories, advanced imaging equipment, fl ow cytometry facilities, a clinical pharmacokinetics laboratory and other facilities. As a member of the Shared Core Facilities Initiative, OHRI makes many of its facilities available to the broader academic health research community in Ottawa.

www.ohri.ca/About/Facilities.asp

Pharmaceutical Production Research Facility, Calgary, AB

Commercializing media development and bioreactor protocols for the expansion of mammalian neural stem cells, as well as developing expansion protocols for pancreatic endocrine tissue and progenitor cells, mesenchymal stem cells, hepatic oval stem cells, embryonic stem cells and mammary stem cells.

www.pprf.ca

Philip S. Orsino Cell Therapy Facility, Princess Margaret Hospital, Toronto, ON23

A state-of-the-art facility offering Good Manufacturing Practice (GMP) grade cell and tissue processing capabilities.

www.uhnres.utoroto.ca/facilities/psoctf/

table 5. Support Facilities for Stem Cell and Regenerative Medicine Research


29


Ontario Human Induced Pluripotent Stem Cell Facility, MaRS Centre, Toronto, ON

Develops best practices in the technologies of reprogramming with a focus on the establishment and banking of patient-specifi c primary fi broblast cell lines, and the subsequent generation and characterization of iPS cells.

www.ontarioips.ca

StemBase, Ottawa Health Research Institute, ON

The largest stem cell gene expression database in the world containing information on genomic and proteomic analysis of stem cells.

www.stembase.ca

Toronto Centre for Phenogenomics, Mount Sinai Hospital, Toronto, ON

Conducts and supports genetic research involving generation of mutant mice, physiological phenotyping, behavioural analysis, imaging, pathology and cryopreservation for storage and distribution. Services include generation of novel ES cell lines, and expansion of ES cell clones.

www.phenogenomics.ca

RELEVANT SUPPORT FACILITIES 6

inside7.1 National and International Networks7.2 Provincial Networks pH

oto

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31

netWorKs7.1 National and International NetworksCanada’s stem cell and regenerative medicine researchers are members of a number of diff erent relevant national and international networks. Th ese include those networks described in Table 6. Unless otherwise indicated, the description information has been sourced from the URL listed in the table.

7.2 Provincial NetworksTh ere are also a number of provincial research networks to which researchers belong. Th ese include those listed in Table 7.27

32



national

Stem Cell Network (SCN) Headquartered at U. Ottawa, ON, this federal government-funded Network of Centers of Excellence (NCE) was formed in 2001 and currently includes 96 researchers and 167 industry, public service and academic partners. It is a catalyst for enabling translation of stem cell research into clinical applications, commercial products or public policy. It will receive $63.62M in federal government funding between 2001 & 2012.

www.stemcellnetwork.ca

Centre for Commercialization of Regenerative Medicine (CCRM)

This federal government-funded Centre of Excellence for Commercialization and Research (CECR) was established at the end of 2010 at U. Toronto, ON. It aims to accelerate the commercialization of regenerative medicine technologies by bringing together business leadership and innovative stem cell and biomaterial technology development. It will receive $15M in federal government funding between 2011 and 2015.24

www.ccrm.ca

AllerGen NCE Inc. Allergy and asthma research federal government-funded NCE headquartered at McMaster U., ON. Formed in 2004, it funds some stem cell research in asthma and infl ammatory disease.

www.allergen-nce.ca

C17 Council Organization composed of the institutionally appointed heads of the 16 pediatric hematology, oncology, and stem cell transplantation programs in Canada. Acts as an authoritative Canadian voice representing the interests of children and adolescents with cancer and blood disorders.

www.c17.ca

Canadian Blood & Marrow Transplant (BMT) Group

National, voluntary, multi-disciplinary organization providing leadership and promoting excellence in patient care, research and education in the fi eld of blood and marrow transplantation.

www.cbmtg.org

Canadian Tumour Repository Network (CTRNet)

A translational cancer research resource, funded by CIHR, that furthers Canadian health research by linking cancer researchers with provincial tumour banks.

www.ctrnet.ca

international

Cancer Stem Cell Consortium (CSCC) Founded in 2007 by a group of Canadian funding agencies (CFI, CIHR, Genome Canada, Ontario Institute for Cancer Research, Stem Cell Network) to support international collaboration on research on cancer stem cells. Currently has a strategic partnership with the California Institute for Regenerative Medicine. Aims to secure and manage an estimated $500M in research funds during an initial 5-year period (2009–2014).25

www.cancerstemcellconsortium.ca

International Consortium of Stem Cell Networks

HQ in Ottawa, ON. Consists of 18 stem cell networks from more than 10 countries; currently chaired by Dr. Michael Rudnicki, Scientifi c Director of Canada’s Stem Cell Network.

www.stemcellconsortium.org

International Society for Cellular Therapy

A global association driving the translation of scientifi c research to deliver innovative cellular therapies to patients that was established in 1992. Dr. Armand Keating is on the Mesenchymal and Tissue Stem Cells Committee.

www.celltherapysociety.org

International Society of Stem Cell Research

An independent, nonprofi t organization formed to foster the international exchange of information on stem cell research between the world’s leading stem cell scientists and researchers. HQ in Deerfi eld, Illinois, US. Drs. Connie Eaves and Derek van der Kooy are on the Board of Directors. Dr. Gordon Keller is a member of the Global Advisory Council.

www.isscr.org

table 6. National and International Stem Cell and Regenerative Medicine Networks

33

7NETWORKS


International Stem Cell Forum Consists of 14 leading funders of stem cell research from 13 countries. Founded in January 2003 to encourage international collaboration and funding support for stem cell research. Canada’s member is CIHR.26

N/A

Pediatric Bone and Marrow Transplant Consortium (PBMTC)

A voluntary group of clinicians and scientists that includes over 100 pediatric PBMTC centers in Canada, US, Australia and New Zealand. Purpose is to engage in scientifi c and educational activities related to the use of hematopoietic stem cells in the treatment of diseases of children and adolescents. Canadian members include Alberta Children’s Hospital, BC Children’s Hospital, Cancer Care Manitoba, Centre Hospitalier Universitaire Ste Justine Chu Ste-Justine, McGill University Health Center—Montreal Children’s Hospital, and Sick Kids.

www.pbmtc.org

34

naMe reaCH url

BritisH ColuMBia

BC Network for Aging Research British Columbia www.bcnar.ca

Child & Youth Health Research Network British Columbia www.cyhrnet.ca

BC Clinical Genomics Network British Columbia www.bccgn.ca

BC Preclinical Research Consortium British Columbia www.bcprc.ca

BC Biolibrary British Columbia www.bcbiolibrary.icapture.ubc.ca

BC Proteomics Network British Columbia www.bcproteomicsnetwork.ca

British Columbia Pancreatic Cancer Research Net

British Columbia www.bccancer.bc.ca/RES/ResearchPrograms/bcpcr/default.htm

Brain Research Centre British Columbia www.brain.ubc.ca

ICORD (International Collaboration On Repair Discoveries)

British Columbia icord.org

Centre for Lymphoid Cancer British Columbia www.bccancer.bc.ca/RES/ResearchPrograms/LymphoidCancers/default.htm

alBerta

Joint Injury and Arthritis Research Group Alberta www.albertahealthservices.ca/services.asp?pid=service&rid=1715

sasKatCHeWan

Airways Research Group U. Saskatchewan www.medicine.usask.ca/research/health-research-groups/airways-research-group/index.html

ManitoBa

Manitoba Neuroscience Network Manitoba www.sbrc.ca/mnn/

Spinal Cord Research Centre U. Manitoba www.scrc.umanitoba.ca/SCRC/About.html

Medical Genetics Research Group Manitoba www.umanitoba.ca/faculties/medicine/units/biochem/research/genetics.html

ontario

Health Services Research Network (cancer research)

Ontario www.oicr.on.ca/newsreleases/2010/Backgrounder_Health_Services_Research_July122010.pdf

Imaging Network Ontario Ontario sunnybrook.ca/research/content/?page=sri_proj_imno_home

Ontario Cancer Genetics Network Ontario www.cancercare.on.ca/cms/one.aspx?pageId=10051

Ontario Stem Cell Initiative (virtual network of over 60 stem cell scientists in Ontario)

Ontario www.ontariostemcell.ca

Ontario Translational Research Network (cancer research)

Ontario www.otrn.ca

QuÉBeC

Network for Oral and Bone Health Research Québec www.rsbo.ca

Vision Research Network Québec www.visionnetwork.ca

table 7. Provincial Networks for Stem cell and Regenerative Medicine Researchers


35

naMe reaCH url

Cancer Research Network Québec www.rrcancer.ca

Réseau de thérapie cellulaire et tissulaire (ThéCell)

Québec www.reseauthecell.qc.ca

Groupe de recherche en sciences et technologies biomédicales (GRSTB)

Institut de génie biomédical of École polytechnique Montréal

www.polymtl.ca/recherche/rc/unites/details.php?NoUnite=42

Groupe de recherche sur le système nerveux central

Faculty of Medicine of Université de Montréal

www.grsnc.umontreal.ca

Montréal Diabetes Research Center Montréal Institutions www.montreal-diabetes-research-center.org/en/index.asp

MaritiMe provinCes

Atlantic Path Research Network (cancer research)

Nova Scotia, New Brunswick, Prince Edward Island, Newfoundland and Labrador

atlanticpath.ca/research/research.html

New Brunswick Cancer Network New Brunswick www.gnb.ca/0051/cancer/index-e.asp

7NETWORKS

inside8.1 Key Researchers8.2 Key Research Institutions

37

KeY researCHers and institutions8.1 Key ResearchersTh ere are several ways to measure the importance of a researcher, including:

• Key contributions• Amount of research funding received • Position within key research institutes• Endowed Chair• Number of publications • Number of citations.

Each of the six criteria metrics provides diff erent outcomes, as described below, but the 21 researchers listed in Table 8 all score high on key contributions and/or levels of research funding ($5 million or greater used as excellence level). Th ree researchers score high on all criteria, while at least eight other researchers score high on a minimum of four of the six criteria (from the information that was available for this project; publication, citation, and contributions data are missing for a number of researchers):

• Mick Bhatia, McMaster University—scores high on all six criteria

• John Dick, University of Toronto—scores high on all six criteria

• Janet Rossant, University of Toronto—scores high on all six criteria

• Connie Eaves—scores high on four criteria

• Keith Humphries—scores high on four criteria

• Armand Keating, University of Toronto—scores high on fi ve criteria

• Gordon Keller—scores high on four criteria• Freda Miller—scores high on four criteria• Andras Nagy, University of Toronto—

scores high on fi ve criteria• Michael Rudnicki, University of Ottawa—

scores high on four criteria• Guy Sauvageau, Université de Montréal—

scores high on four criteria.

In terms of amount of funding received within the constraints of the methodology used in this Asset Map (see Appendix 1), 51 of the 416 researchers received funding of more than $1 million over a five year period (2006/7 to 2010/11). The 13 who received funding of over $5 million are all listed in Table 8, as are two researchers who have recently received over $5 million of funding for use over the next five years from either the Ontario Government (Greenblatt) or Networks of Centres of

38


Excellence (NCE) (Zandstra). Thirteen of the 21 key researchers are directors of or hold similar positions within their research institutions and 11 of these received funding of over $5 million.

As mentioned above, another way of measuring a researcher’s importance is whether or not (s)he holds an endowed Chair. Eighty one of the 416 researchers are Chairholders, 69 of whom are Canada Research Chairs (CRCs). The latter

are high level research professorships created by the Canadian Government to attract and retain some of the world’s most accomplished and promising minds. Eleven Chairholders who have made significant achievements in stem cell/regenerative medicine research and/or received high levels of funding (over $5 million) are shown in Table 8 while the rest are listed in Appendix 3a. Furthermore, using data from Scopus (www.scopus.com), Industry Canada’s Life

table 8. Researchers Who Have Made or Are Making Signifi cant Contributions to Stem Cell Research

researCHer researCH institution and position universitY affiliation endoWed CHair

funding BetWeen 2006/07 & 2010/11a

# puBs. 2005–2010b

Citation indeX (H-indeX)b

KeY ContriButions (froM info. supplied BY industrY Canada onlY, unless otHerWise indiCated)

Bhatia, Mickc Director and Senior Scientist, Stem Cell and Cancer Research Institute

McMaster U., ON CRC in Human Stem Cell Biology; Krembil Chair in Stem Cell Biology

$5M+ 22 13 Developed a process to transform skin cells into stem cells.29

Dick, John Director, Program in Cancer Stem Cells—Genesis, Ontario Institute for Cancer Research

U. Toronto, ON CRC in Stem Cell Biology $5M+ 18 13 Isolated the fi rst cancer stem cell, in acute myeloid leukemia (1994), and subsequent ones in other tumors.

Dirks, Peter Scientist & Principal Investigator, Hospital for Sick Children (Sick Kids)

U. Toronto < $1M N/A N/A Isolated and characterized cancer stem cells from human brain tumours of different phenotypes that express neural stem cell markers and have stem cell-like behaviour in vitro and in vivo.

Eaves, Connie Director, Co-founder, and Senior Scientist, Terry Fox Laboratory; VP Research BC Cancer Agency

UBC, BC $1M–$2.5M 30 14 Pioneering research in basic blood stem cell biology. Discovered breast stem cells. Developed stem cell assays.

Greenblatt, Jack Principal Investigator, The Donnelly Centre, Banting and Best Department of Medical Research

U. Toronto, ON $1M–$2.5M N/A N/A A $5.27M grant for 2011–2014 from the Ontario Government for Protein Complexes in the Epigenetics of Human Disease and Stem Cell Fate research.

Humphries, Keith Director & Distinguished Scientist, Terry Fox Laboratory, BC Cancer Agency

UBC, BC $5M+ 15 8 N/A

Keating, Armand Director, Cell Therapy Program and the Orsino Cell Therapy Translational Research Lab., Princess Margaret Hospital

U. Toronto, ON Epstein Chair in Cell Therapy & Transplantation

$5M+ 33 12 N/A

Keller, Gordon Director, McEwen Centre for Regenerative Medicine and Senior Scientist, Ontario Cancer Institute

U. Toronto, ON CRC in Embryonic Stem Cell Biology

$5M+ N/A N/A Demonstrated that human heart progenitor cells could be grown from embryonic stem cells (2008).30

Korbutt, Gregory Director, Human Islet Quality Control Laboratory, Alberta Diabetes Institute

U. Alberta, AB $5M+ N/A N/A N/A

Miller, Freda Senior Scientist, Developmental & Stem Cell Biology program, Hospital for Sick Children (Sick Kids)

U. Toronto, ON CRC in Developmental Neurobiology

$4M–$5M 16 11 Demonstrated the existence of stem cells in adult skin tissue, and that they could be used to grow nerve cells that could potentially help people with spinal cord injuries or Parkinson’s disease.

Nagy, Andrasd Senior Investigator, Samuel Lunenfeld Research Institute, Mount Sinai Hospital and Investigator, McEwen Centre for Regenerative Medicine

U. Toronto, ON CRC in Stem Cells and Regeneration

$5M+ 18 8 Reconstituted a mouse from a single embryonic stem cell, thus proving the cells’ inherent and defi ning characteristic of pluripotency.31 Established Canada’s fi rst—and to date only—human embryonic stem cell lines (2005). Developed method to create induced pluropotent stem cells (iPS) cells without the use of retroviruses (2009).

Paige, Christopher VP Research, Ontario Cancer Institute U. Toronto, ON $5M+ N/A N/A N/A

39

8KEY RESEARCHERS AND INSTITUTIONS

Science Industries Branch and Science-Metrix on publications and citations,28 at least nine of the 21 researchers had a significant number of publications and citations. The majority of the other researchers probably also had numerous well-cited publications but the data for these could not be collected for this report.

8.2 Key Research InstitutionsAs with researchers, there are several ways of measuring institutional importance, including:

• Amount of funding received• Number of researchers• Number of endowed Chairs• Number of publications and citations.

Th ese criteria metrics give slightly diff erent results in terms of key institutions.

As indicated in section 3.3 and Table 1, 25 of Canada’s universities are associated with stem cell and regenerative medicine research. Associated with the fact that Ontario received 65% of funding (Figure 2



# puBs. 2005–2010b



Bhatia, Mickc Director and Senior Scientist, Stem Cell and Cancer Research Institute

McMaster U., ON CRC in Human Stem Cell Biology; Krembil Chair in Stem Cell Biology

$5M+ 22 13 Developed a process to transform skin cells into stem cells.29

Dick, John Director, Program in Cancer Stem Cells—Genesis, Ontario Institute for Cancer Research

U. Toronto, ON CRC in Stem Cell Biology $5M+ 18 13 Isolated the fi rst cancer stem cell, in acute myeloid leukemia (1994), and subsequent ones in other tumors.

Dirks, Peter Scientist & Principal Investigator, Hospital for Sick Children (Sick Kids)

U. Toronto < $1M N/A N/A Isolated and characterized cancer stem cells from human brain tumours of different phenotypes that express neural stem cell markers and have stem cell-like behaviour in vitro and in vivo.

Eaves, Connie Director, Co-founder, and Senior Scientist, Terry Fox Laboratory; VP Research BC Cancer Agency

UBC, BC $1M–$2.5M 30 14 Pioneering research in basic blood stem cell biology. Discovered breast stem cells. Developed stem cell assays.

Greenblatt, Jack Principal Investigator, The Donnelly Centre, Banting and Best Department of Medical Research

U. Toronto, ON $1M–$2.5M N/A N/A A $5.27M grant for 2011–2014 from the Ontario Government for Protein Complexes in the Epigenetics of Human Disease and Stem Cell Fate research.

Humphries, Keith Director & Distinguished Scientist, Terry Fox Laboratory, BC Cancer Agency

UBC, BC $5M+ 15 8 N/A

Keating, Armand Director, Cell Therapy Program and the Orsino Cell Therapy Translational Research Lab., Princess Margaret Hospital

U. Toronto, ON Epstein Chair in Cell Therapy & Transplantation

$5M+ 33 12 N/A

Keller, Gordon Director, McEwen Centre for Regenerative Medicine and Senior Scientist, Ontario Cancer Institute

U. Toronto, ON CRC in Embryonic Stem Cell Biology

$5M+ N/A N/A Demonstrated that human heart progenitor cells could be grown from embryonic stem cells (2008).30

Korbutt, Gregory Director, Human Islet Quality Control Laboratory, Alberta Diabetes Institute

U. Alberta, AB $5M+ N/A N/A N/A

Miller, Freda Senior Scientist, Developmental & Stem Cell Biology program, Hospital for Sick Children (Sick Kids)

U. Toronto, ON CRC in Developmental Neurobiology

$4M–$5M 16 11 Demonstrated the existence of stem cells in adult skin tissue, and that they could be used to grow nerve cells that could potentially help people with spinal cord injuries or Parkinson’s disease.

Nagy, Andrasd Senior Investigator, Samuel Lunenfeld Research Institute, Mount Sinai Hospital and Investigator, McEwen Centre for Regenerative Medicine

U. Toronto, ON CRC in Stem Cells and Regeneration

$5M+ 18 8 Reconstituted a mouse from a single embryonic stem cell, thus proving the cells’ inherent and defi ning characteristic of pluripotency.31 Established Canada’s fi rst—and to date only—human embryonic stem cell lines (2005). Developed method to create induced pluropotent stem cells (iPS) cells without the use of retroviruses (2009).

Paige, Christopher VP Research, Ontario Cancer Institute U. Toronto, ON $5M+ N/A N/A N/A

40



# puBs. 2005–2010b



Rossant, Janet Chief of Research, Hospital for Sick Children (Sick Kids) U. Toronto, ON Lombard Insurance Chair $5M+ 25 11 Reconstituted a mouse from a single embryonic stem cell, thus proving the cells’ inherent and defi ning characteristic of pluripotency.32

Rudnicki, Michael Director and Senior Scientist, Sprott Centre for Stem Cell Research (also Scientifi c Director, Stem Cell Network)

U. Ottawa CRC in Molecular Genetics $5M+ N/A N/A Discovered adult muscle stem cells.

Sauvageau, Guy Chief Executive Offi cer and founding Scientifi c Director, Institute for Research in Immunology and Cancer

U. Montréal, QC CRC in the Molecular Genetics of Stem Cells

$5M+ N/A N/A Developed the use of recombinant proteins allowing for the expansion of the hematopoietic stem cells.

Sefton, Michael Principal Investigator, Donnelly Centre for Cellular and Biomolecular Research

U. Toronto, ON Michael E. Charles Chair in Chemical Engineering

$5M+ N/A N/A N/A

Till, Jim Senior Scientist, Ontario Cancer Institute U. Toronto, ON Semi-retired N/A N/A Demonstrated the existence of stem cells (1961).

van der Kooy, Derek Professor, Department of Medical Genetics and Microbiology

U. Toronto, ON $2.5M–$4M 16 10 Identifi ed retinal stem cells in mice (1994). Identifi ed retinal stem cells in the human eye (2000).

Weisel, Richard Director, Toronto General Research Institute U. Toronto, ON $5M+ N/A N/A N/A

Weiss, Samuel Director, Hotchkiss Brain Institute U. Calgary, AB $1M–$2.5M N/A N/A Identifi ed stem cells in the adult human brain (1992)—discovered a mammalian central nervous system (CNS) stem cell.

Zandstra, Peter McEwen Centre for Regenerative Medicine, University Health Network and Institute of Biomaterials and Biomedical Engineering, Donnelly Centre

U. Toronto, ON CRC in Stem Cell Bioengineering < $1M N/A N/A $15M from 2011 for an NCE CECR: Centre for Commercialization of Regenerative Medicine.

a Funding (principally federal) collected according to Methodology described in Appendix 1—includes individual investigator funds from Stem Cell Network.b Only publication and citation data supplied within an internal document provided by Industry Canada’s Life Science Industries Branch were used here—see

above text for reference.c Also has a 2011–2014 grant from the Ontario Government of $9.2M for the Ontario Consortium for Regeneration Inducing Therapeutics (OCRiT).d Also has a 2011–2014 grant from the Ontario Government of $7.25M for a project titled: Molecular pathways of reprogramming—from discovery to novel

therapeutics.


table 8. cont’d

41



# puBs. 2005–2010b



Rossant, Janet Chief of Research, Hospital for Sick Children (Sick Kids) U. Toronto, ON Lombard Insurance Chair $5M+ 25 11 Reconstituted a mouse from a single embryonic stem cell, thus proving the cells’ inherent and defi ning characteristic of pluripotency.32

Rudnicki, Michael Director and Senior Scientist, Sprott Centre for Stem Cell Research (also Scientifi c Director, Stem Cell Network)

U. Ottawa CRC in Molecular Genetics $5M+ N/A N/A Discovered adult muscle stem cells.

Sauvageau, Guy Chief Executive Offi cer and founding Scientifi c Director, Institute for Research in Immunology and Cancer

U. Montréal, QC CRC in the Molecular Genetics of Stem Cells

$5M+ N/A N/A Developed the use of recombinant proteins allowing for the expansion of the hematopoietic stem cells.

Sefton, Michael Principal Investigator, Donnelly Centre for Cellular and Biomolecular Research

U. Toronto, ON Michael E. Charles Chair in Chemical Engineering

$5M+ N/A N/A N/A

Till, Jim Senior Scientist, Ontario Cancer Institute U. Toronto, ON Semi-retired N/A N/A Demonstrated the existence of stem cells (1961).

van der Kooy, Derek Professor, Department of Medical Genetics and Microbiology

U. Toronto, ON $2.5M–$4M 16 10 Identifi ed retinal stem cells in mice (1994). Identifi ed retinal stem cells in the human eye (2000).

Weisel, Richard Director, Toronto General Research Institute U. Toronto, ON $5M+ N/A N/A N/A

Weiss, Samuel Director, Hotchkiss Brain Institute U. Calgary, AB $1M–$2.5M N/A N/A Identifi ed stem cells in the adult human brain (1992)—discovered a mammalian central nervous system (CNS) stem cell.


U. Toronto, ON CRC in Stem Cell Bioengineering < $1M N/A N/A $15M from 2011 for an NCE CECR: Centre for Commercialization of Regenerative Medicine.


42

above), the University of Toronto received the lion’s share of funds between 2006/7 and 2010/11, at $117 million (see Figure 3 above). Th is was followed by the University of Ottawa and Université de Montréal. In terms of researchers, the order of importance of the universities changes somewhat. Th e University of Toronto remains the most important, followed by the University of British Columbia, the University of Ottawa, McGill University, and Université de Montréal (see Figure 5 above, Table 9 and Appendix 4). Th e University of Toronto has the most endowed Chairs although there is a higher percentage of Chairs as a ratio of researchers at many of the other universities with more than 10 relevant investigators. On this measure, Université de Montréal comes fi rst (Table 9).

Within or affi liated with the universities are key research organizations, listed in Appendix 4. Th e seven largest of these in terms of numbers of stem cell and regenerative medicine researchers are described in Table 10. Four are affi liated with the University of Toronto (in order of researcher numbers: Ontario Cancer Institute, Sick Kids, McEwen Centre, Sunnybrook) and one of each is affi liated with the University of British Columbia (Terry Fox Laboratory), Université Laval (LOEX), and the University of Ottawa (Sprott Centre). All have endowed Chairs, with the most residing at McEwen (n=6), Sprott (n=5), and Sick Kids (n=4). Table 11 lists 10 other research institutes that each house fi ve or more investigators: three affi liated with the University of British Columbia, two with the University of Toronto, and one each with the University

of Calgary, McMaster University, the University of Ottawa, McGill University and Université de Montréal. In addition, although housing fewer than fi ve researchers (by this report’s analysis), the Institute of Cell Biology at the University of Manitoba is also considered to be a key institution by interviewees.

In terms of publications and citations, data from Industry Canada33 showed that between 1996 and 2009, Canada published over 1,050 regenerative medicine research papers. Overall, Canadian papers in regenerative medicine were cited 30% more oft en than the world average as indicated in Table 10 for our key universities: the University of Toronto, McGill University, and the University of British Columbia, as well as the University of Alberta, the University of Calgary, and McMaster University.


43

provinCe universitY# relevant researCHers

# relevant endoWed CHairs (% of researCHers)

# puBs/ sCi. iMpaCt *

ranK BY researCHer #

alBerta

U. Alberta 16 4 (25%) 116/1.7 10

U. Calgary 21 1 (5%) 60/1.6 7

BC

SFU 1 0 N/A 21 joint

UBC 50 7 (14%) 121/1.3 2

U. Victoria 2 1 (50%) N/A 19

ManitoBa

U. Manitoba 11 2 (18%) N/A 11

neW BrunsWiCK

New Brunswick Heart Centre 1 0 N/A 21 joint

neWfoundland & laBrador

Memorial U. 1 0 N/A 21 joint

nova sCotia

Dalhousie U. 11 1 (9%) N/A 12

ontario

Carleton U. 1 0 N/A 21 joint

McMaster U. 19 5 (26%) 75/1.1 8

Queen’s U. 9 1 (11%) N/A 13

U. Guelph 1 0 N/A 21 joint

U. Ottawa 34 9 (26%) N/A 3

U. Toronto 110 24 (22%) 173/1.5 1

U. Waterloo 3 0 N/A 18

U. Western Ontario 17 1 (6%) N/A 9

York U. 1 1 (100%) N/A 20

QuÉBeC

École polytechnique de Montréal 7 3 (43%) N/A 14

McGill U. 33 8 (24%) 89/1.1 4

U. Laval 23 1 (4%) N/A 6

U. Montréal 32 10 (31%) N/A 5

U. Québec à Montréal 3 1 (33%) N/A 17

U. Sherbrooke 4 1 (25%) N/A 16

sasKatCHeWan

U. Saskatchewan 5 0 N/A 15

table 9. Stem Cell and Regenerative Medicine Researchers and Endowed Chairs by University


44

*First number is the number of researchers/second number is number of endowed Chairs.

researCH institutionuniversitY affiliation Head # res./CHairs* desCription url

Ontario Cancer Institute (OCI), UHN [UHN also includes Toronto General Research Institute and Toronto Western Research Institute]

U. Toronto, ON Director OCI: Neel, Benjamin 19/1 Researchers employ state-of-the-art tools in genomics, proteomics, structural biology, molecular biology, biophysics and the behavioural sciences. With these tools they analyze cancerous cells at the molecular level; test gene and cellular therapies for cancer and other diseases; develop new technologies for diagnosing and treating cancer; determine the effects of diet and behaviour on cancer risks; and develop and test informatics tools for the large-scale analysis of patient populations.

www.uhnresearch.ca/institutes/oci

Hospital for Sick Children (Sick Kids) U. Toronto, ON Chief of Research: Rossant, Janet 16/4 One of the world’s foremost paediatric health-care institutions and Canada’s leading centre dedicated to advancing children’s health through the integration of patient care, research and education. SickKids is one of Canada’s most research-intensive hospitals and has generated discoveries that have helped children globally.

www.sickkids.ca

Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute (OHRI)

U. Ottawa, ON Director Sprott: Rudnicki, Michael; CEO & Sci. Director OHRI: Stewart, Duncan

14/5 One of the leading regenerative medicine centres in Canada. Houses the OHRI’s Regenerative Medicine Program (which encompasses basic sciences such as stem cell biology, molecular genetics and molecular biology, and applied sciences such as transplantation and tissue engineering); headquarters for Canada’s Stem Cell Network. Provides an important hub for stem cell research community in Ottawa.

www.ohri.ca/centres/StemCellResearch/default.asp

McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network (UHN)

U. Toronto, ON Director McEwan: Keller, Gordon 12/6 Aims to be a world-renowned centre for stem cell biology and regenerative medicine. Working to accelerate the development of more effective treatments for conditions such as heart disease, diabetes, respiratory disease and spinal cord injury. Distributes their stem cells globally.

www.mcewencentre.com

Sunnybrook Research Institute (SRI), Sunnybrook Health Sciences Centre (SHSC)

U. Toronto, ONVP Research SRI: Julius, Michael

12/1 Main aims are to understand and prevent disease, and develop treatments that enhance and extend life. Main areas of expertise are in clinical epidemiology and health sciences; clinical integrative biology; imaging; and molecular and cellular biology.

sunnybrook.ca/research

Terry Fox Research Labs. UBC thru BCCA, BC

Director: Humphries, Keith 10/1 Aims to fuel major improvements in cancer outcomes through basic and translational research with a current focus on cancer stem cells. Faculty comprise experts with diverse backgrounds in biology and medicine and internationally recognized leadership in normal and leukemic stem cell investigations, innate and acquired immunity, embryo and tissue development, telomere biology and aging, signalling, genomics, live cell banking, cell separation, imaging and molecular analysis, and bioinformatics and data management. Strategies range from the investigation of model organisms to experiments with patient’s cells and the initiation and laboratory support of clinical trials.

www.terryfoxlab.ca

LOEX (Experimental Organogenesis Laboratory—Laboratoire d’organogénèse expérimentale)

U. Laval, QC Director: Auger, François A Sci. Director: Germain, Lucie

10/1 An international leader in tissue engineering. Its strength lies principally in epidermal culture and its self-assembly approach to tissue engineering. Activities cover four major areas: Stem cells, differentiation and cellular interactions; Cutaneous, cardiovascular, orthopedic, ophthalmologic, pulmonary and urinary tissue reconstruction; Biological applications of reconstructed tissues (physiology, pathophysiology, pharmacology, toxicology, transplantation) and pre-clinical trials; Clinical applications of cellular and tissue-based therapies.

www.cha.quebec.qc.ca/en/www/research/index.html

www.loex.qc.ca

table 10. Institutions Housing More Than Ten Researchers in Stem Cell and Regenerative Medicine Research


45

researCH institutionuniversitY affiliation Head # res./CHairs* desCription url

Ontario Cancer Institute (OCI), UHN [UHN also includes Toronto General Research Institute and Toronto Western Research Institute]

U. Toronto, ON Director OCI: Neel, Benjamin 19/1 Researchers employ state-of-the-art tools in genomics, proteomics, structural biology, molecular biology, biophysics and the behavioural sciences. With these tools they analyze cancerous cells at the molecular level; test gene and cellular therapies for cancer and other diseases; develop new technologies for diagnosing and treating cancer; determine the effects of diet and behaviour on cancer risks; and develop and test informatics tools for the large-scale analysis of patient populations.


Hospital for Sick Children (Sick Kids) U. Toronto, ON Chief of Research: Rossant, Janet 16/4 One of the world’s foremost paediatric health-care institutions and Canada’s leading centre dedicated to advancing children’s health through the integration of patient care, research and education. SickKids is one of Canada’s most research-intensive hospitals and has generated discoveries that have helped children globally.

www.sickkids.ca

Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute (OHRI)

U. Ottawa, ON Director Sprott: Rudnicki, Michael; CEO & Sci. Director OHRI: Stewart, Duncan

14/5 One of the leading regenerative medicine centres in Canada. Houses the OHRI’s Regenerative Medicine Program (which encompasses basic sciences such as stem cell biology, molecular genetics and molecular biology, and applied sciences such as transplantation and tissue engineering); headquarters for Canada’s Stem Cell Network. Provides an important hub for stem cell research community in Ottawa.

www.ohri.ca/centres/StemCellResearch/default.asp

McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network (UHN)

U. Toronto, ON Director McEwan: Keller, Gordon 12/6 Aims to be a world-renowned centre for stem cell biology and regenerative medicine. Working to accelerate the development of more effective treatments for conditions such as heart disease, diabetes, respiratory disease and spinal cord injury. Distributes their stem cells globally.

www.mcewencentre.com

Sunnybrook Research Institute (SRI), Sunnybrook Health Sciences Centre (SHSC)

U. Toronto, ONVP Research SRI: Julius, Michael

12/1 Main aims are to understand and prevent disease, and develop treatments that enhance and extend life. Main areas of expertise are in clinical epidemiology and health sciences; clinical integrative biology; imaging; and molecular and cellular biology.

sunnybrook.ca/research

Terry Fox Research Labs. UBC thru BCCA, BC

Director: Humphries, Keith 10/1 Aims to fuel major improvements in cancer outcomes through basic and translational research with a current focus on cancer stem cells. Faculty comprise experts with diverse backgrounds in biology and medicine and internationally recognized leadership in normal and leukemic stem cell investigations, innate and acquired immunity, embryo and tissue development, telomere biology and aging, signalling, genomics, live cell banking, cell separation, imaging and molecular analysis, and bioinformatics and data management. Strategies range from the investigation of model organisms to experiments with patient’s cells and the initiation and laboratory support of clinical trials.

www.terryfoxlab.ca


U. Laval, QC Director: Auger, François A Sci. Director: Germain, Lucie

10/1 An international leader in tissue engineering. Its strength lies principally in epidermal culture and its self-assembly approach to tissue engineering. Activities cover four major areas: Stem cells, differentiation and cellular interactions; Cutaneous, cardiovascular, orthopedic, ophthalmologic, pulmonary and urinary tissue reconstruction; Biological applications of reconstructed tissues (physiology, pathophysiology, pharmacology, toxicology, transplantation) and pre-clinical trials; Clinical applications of cellular and tissue-based therapies.

www.cha.quebec.qc.ca/en/www/research/index.html

www.loex.qc.ca

researCH instituteuniversitY affiliation

# res./CHairs * url

Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto, ON 8/3 www.lunenfeld.ca

The Donnelly Centre U. Toronto, ON 8/2 thedonnellycentre.utoronto.ca

Stem Cell and Cancer Research Institute McMaster U., ON 7/4 sccri.mcmaster.ca

Institut de recherches cliniques de Montréal U. Montréal, QC 7/3 ircm.qc.ca

Hotchkiss Brain Institute U. Calgary, AB 7/1 www.hbi.ucalgary.ca

Vancouver Coastal Health Research Institute UBC, BC 7/0 www.vchri.ca

BC Cancer Agency (excl. Terry Fox Laboratory) UBC, BC 6/1 www.bccrc.ca

Biomedical Research Centre UBC, BC 6/1 www.brc.ubc.ca

Ottawa Hospital Research Institute U. Ottawa, ON 5/1 www.ohri.ca

The Research Institute of the McGill University Health Centre

McGill U., QC 5/0 muhc.ca

*First number is the number of researchers/second number is number of Endowed Chairs.

table 11. Research Institutes Housing between Five and Ten Researchers



46

In keeping with the fact that Canadian researchers were the fi rst to identify many types of stem cells, Canada has a signifi cant number of current researchers in this fi eld (416 in professor or associate professor positions), many of them internationally renowned. Canada remains among the world leaders in stem cell research, with Ontario, and the University of Toronto in particular, having the greatest number of

researchers and highest levels of funding. Researchers’ main area of focus is tissue-specifi c stem cells (not embryonic stem cells as may have been assumed), particularly hematopoietic, and the most common disease area targeted is cancer. However, a number of other disease areas are also important, particularly neurological, musculoskeletal, and cardiovascular conditions.

ConClusion

We would like to thank everyone who participated in the creation of this document including Eric Cloutier, Policy Advisor, Life Science Industries Branch, Industry Sector, Industry Canada; Sue Kingsley, President, International BioPharma Solutions Ltd. (IBPS); Richard Taylor, via IBPS; Helen Kingsley, via IBPS; Drew Lyall, Executive Director, Canadian Stem Cell Network and Board of Directors of the Canadian Stem Cell Foundation and Canadian Stem Cell Consortium; Michael Rudnicki, Scientifi c Director, Canadian Stem Cell Network and Senior Scientist and Director of the Regenerative Medicine Program and the Sprott Centre for Stem

Cell Research, Ottawa Hospital Research Institute; Cindy Bell, Interim Executive Director, Cancer Stem Cell Consortium and Executive VP Corporate Development, Genome Canada; Gordon Keller, Canada Research Chair in Embryonic Stem Cell Biology, Director, McEwen Centre for Regenerative Medicine, University Health Network, University of Toronto; Juan Carlos Zúñiga-Pfl ücker, Director of the Advanced Regenerative Tissue Engineering Centre, University of Toronto; Jim Till, President, Cancer Stem Cell Consortium and Board of Directors of the Canadian Stem Cell Foundation.

aCKnoWledgeMents

47

ContaCtsIndustry Canada, Life Science Industries BranchEric [email protected]/lsib

International BioPharma Solutions Ltd.Sue Kingsley604-408-4310sue@biopharmasolutions.comwww.BioPharmaSolutions.com

1 Methodology tHis asset Map Was Created as folloWs:1. Initial information on regenerative medicine research in Canada was obtained from:

• Provincial regenerative medicine asset maps:

– Ontario’s MaRS Regenerative Medicine 2009 Industry Briefi ng report (www.marsdd.com/buzz/reports/regenerativemedicine)

– Ontario’s MaRS Regenerative Medicine Asset Map 2009 (www.trra.ca/en/sectors/resources/MRI_asset_maps_RM_050809.pdf)

– Th e BC Regenerative Medicine Asset Map (www.tted.gov.bc.ca/MIT/SBIIO/Documents/AssetMap_RegenMed.pdf)

• Th e websites of: – Canada Research Chairs (www.chairs-chaires.gc.ca)

– Canadian Stem Cell Network (www.stemcellnetwork.ca)

– Canadian Stem Cell Consortium (www.cancerstemcellconsortium.com)

– Canadian Stem Cell Foundation (stemcellfoundation.ca/#/aboutUs)

• Industry Canada’s Life Science Industries Branch.

2. Using this information, we identifi ed key leaders within the area of Canadian regenerative medicine research. We contacted 10 of these individuals by email to ask for an interview or for information. Six replied and, using a discussion guide we created for this purpose, we interviewed fi ve (listed in Appendix 2) to gain factual information and inform the structure and contents of the fi nal report.

3. Th e results of the interviews informed some of the other secondary research sources we used to obtain information on regenerative medicine researchers and research centres in Canada. Information was obtained from the websites and reports listed in activity (1), as well as the following websites, using key word searches “stem cells”, “tissue engineering”, and “regenerative”. Data on researchers and their projects (as well as their associated funding, where available) were obtained for the past 5 years (2006/7 to 2010/11) and, in some cases, into the future from:

• Canada Foundation for Innovation (www.innovation.ca/projects/index.cfm)

• Canadian Institutes of Health Research (www.cihr-irsc.gc.ca/e/826.html)

• Genome Canada (www.genomecanada.ca/en/portfolio/project/health.aspx; www.genomecanada.ca/en/portfolio/project/technologies.

appendiX

48

49

aspx; genomereports.ca/section.php?Lang=En&ID=3&Nav=Section)

• Networks of Centres of Excellence (www.nce-rce.gc.ca/NetworksCentres-CentresReseaux/NCE-RCE_eng.asp)

• National Research Council Canada (www.nrc-cnrc.gc.ca)

• Natural Sciences and Engineering Research Council of Canada (www.outil.ost.uqam.ca/crsng/Outil.aspx?Langue=Anglais)

• US National Institutes of Health (projectreporter.nih.gov/reporter.cfm)

• Terry Fox Foundation (www.tfri.ca/programs/foundation_programs.asp)

• Wellcome Trust (www.wellcome.ac.uk/Funding/International/index.htm —no Canadian projects found)

• MSFHR (Michael Smith Foundation for Health Research: www.msfh r.org)

• Alberta Heritage Foundation for Medical Research—Alberta Innovates (www.ahfmr.ab.ca/experts/search.php)

• Saskatchewan Health Research Foundation (www.shrf.ca)

• Manitoba Health Research Council (researcherdirectory.mb.ca/eprojects/prod/mhrc/mhrcdirectory/index.html)

• Ontario Ministry of Research and Innovation (www.mri.gov.on.ca/english/default.asp)

• Fonds de la Recherche en Santé du Québec (www.frsq.gouv.qc.ca/en/recherche_sante/expertise_quebecoise.shtml)

• Nova Scotia Health Research Foundation (www.nshrf.ca/AbsPage.aspx?siteid=1&lang=1&id=1)

• New Brunswick Health Research Foundation (www.nbhrf.com)

• Newfoundland and Labrador Centre for Applied Health Research (www.nlcahr.mun.ca/research/).

4. Information obtained on researchers from all the aforementioned websites and asset maps was entered into a master Excel spreadsheet. Over 2,000 lines of data were checked for relevance to this project: studentship (undergraduate, Master’s, Doctoral) and postdoctoral fellowship projects and duplicates were deleted; and researchers’ location and activities were checked against their websites to ensure they worked in the research areas covered by this Asset Map and were still residents of Canada. Researchers’ specialties were determined from their funded projects and websites. International reputation was also considered in terms of endowed research chairs and key accomplishments, with data for these being obtained from both CRC and researcher websites, as well as Industry Canada.

5. In terms of funding, dollar amounts were generally only available from federal databases: CFI, CIHR, NSERC, Genome Canada, and NIH. Funding amounts were also available from the Terry Fox Foundation and for some projects supported by the Ontario Ministry of Research and Innovation and Saskatchewan Health Research Foundation. Th e amount of NCE funding was generally gleaned from press releases. CRC funding was calculated according to the number of years a researcher had been a CRC at $100,000/yr for 5 years for a Tier 2 researcher and $200,000/yr for Tier 1 researcher. Such calculations were only conducted if the CRC funding was not included in the NSERC or CIHR information obtained. Where large-scale grants had been announced before January 2011 but monies would be released in the future, only funds deemed to have been used up to 2010/11 were included in the analyses. However, it was not always possible to determine when

appendiXMETHODOLOGY 1

50

the money was made available and in those cases, funds were assumed to be released within a few months of the announcement.

Although the SCN breaks down its funds for individual research projects, generally only total NCE funding for the Network was used in the analysis as the individual data were not identifi ed until the end of this project. Th e NCE funds were dedicated to the University of Ottawa where the SCN is located. NCE funds comprised less than 10% of total funding so although a breakdown according to SCN grants across Canada would have made some diff erence to provincial and university funding (Figures 2 and 3), it would probably have not been signifi cant except as concerns the University of Ottawa. Even so, this university would still have ranked among the top fi ve. On the other hand, funding for key researchers (Section 8.1) did include those granted by the SCN.

6. Th e data for each relevant researcher were categorized according to institution, province, and key research areas. When key research institutes had been identifi ed from this categorization, the websites of those institutes were checked to locate other researchers that may have been missed.

7. Analyses were conducted in Excel to determine researcher numbers, expertise, and government funding according to province and institution; and key researchers according to the amount of funding obtained.

8. For general information on stem cells/ regenerative medicine and Canada’s position in stem research we used the sources listed in Appendix 5, some of which were provided

by interviewees and Industry Canada Life Science Industries Branch.

9. Information on biobank support facilities was obtained from the existing asset maps and Google searches using key words of province or Canada and “cord blood bank”, “tissue bank”, “biobank”, or “biorepository”; some information on biobanks was obtained from www.specimencentral.com/biobank-directory.aspx. Information on other relevant support facilities came from existing asset maps and the research on researchers and their facilities.

10. Information on networks was obtained from Activity (2) interviews, the websites for the FRSQ (www.frsq.gouv.qc.ca/en/index.shtml), NCE (www.nce-rce.gc.ca/NetworksCentres-CentresReseaux/NCE-RCE_eng.asp), and Google searches using key words of province or Canada plus “research network” or “research group”.

11. Information on key research centres was obtained form those centres’ websites.

12. Information on Canada’s global position and expertise was obtained through factual data gathered during Activity 2 interviews, information contained in the MaRS Regenerative Medicine 2009 Industry Briefi ng report, and other publications as shown in Appendix 5.

appendiXMETHODOLOGY1

51

2 Interviewees1. Bell, Cindy. Interim Executive Director, Cancer Stem Cell Consortium and Executive VP Corporate Development, Genome Canada. [email protected]; T: 613-751-4460. Interviewed December 21, 2010.

2. Keller, Gordon. Canada Research Chair in Embryonic Stem Cell Biology, Director, McEwen Centre for Regenerative Medicine, University Health Network, University of Toronto. (www.uhnres.utoronto.ca/researchers/profi le.php?lookup=12091. medbio.utoronto.ca/faculty/keller.html. www.trra.ca/en/profi les/gkeller.asp). [email protected]; T: 416-581-7694. Interviewed Dec 23, 2010.

3. Lyall, Drew (Andrew). Executive Director, Canadian Stem Cell Network and Board of Directors of the Canadian Stem Cell Foundation and Canadian Stem Cell Consortium. (www.stemcellnetwork.ca/index.php?page=network-staff &hl=eng). [email protected]; T: 613-739-6675. Interviewed Dec 17, 2010.

4. Rudnicki, Michael. Scientifi c Director, Canadian Stem Cell NetworkSenior Scientist and Director of the Regenerative Medicine Program and the Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute. (www.ohri.ca/profi les/rudnicki.asp). [email protected]; T: 613-739-6740. Interviewed Dec 20, 2010.

5. Zúñiga-P� ücker, Juan Carlos. Director of the Advanced Regenerative Tissue Engineering Centre, University of Toronto. (www.sunnybrook.ca/research/team/member.asp?t=13&m=191&page=1100) [email protected]; T: 416-480-6112. Interviewed Dec 16, 2010.

appendiXINTERVIEWEES 2

52

researCHer researCH institutionuniversitY/ institution provinCe

tYpe of regen. Med disease

endoWed CHair url eMail

Acker, Jason U. Alberta AB Tissue engineering—cell storage

Various No lmp.med.ualberta.ca/Admin/Faculty/Pages/default.aspx?P=13

[email protected]

Akimenko, Marie-Andrée Ottawa Hospital Research Institute U. Ottawa ON Regeneration—tissue Musculoskeletal No www.careg.uottawa.ca/bio_marie_andree_akimenko.htm

[email protected]

Allan, Alison London Regional Cancer Program, London Health Sciences Centre

U. Western Ontario

ON Stem cells—cancer Cancer—breast No www.uwo.ca/anatomy/department/allana/aallan.html [email protected]

Allan, David Sprott Centre for Stem Cell Research, Ottawa Health Research Institute

U. Ottawa ON Stem cells—hematopoietic

Cardiovascular No www.ohri.ca/profi les/allan.asp [email protected]

Alman, Benjamin Hospital for Sick Children U. Toronto ON Stem cells—mesenchymal

Musculoskeletal CRC in Mus-culoskeletal Research; A.J. Latner Profes-sor and Chair of Orthopaedic Surgery

www.sickkids.ca/AboutSickKids/Directory/People/A/Benjamin-Alman-Staff-Profi le.html

[email protected]

Amsden, Brian Queens U. ON Tissue engineering—scaffolds

Various No chemeng.queensu.ca/people/faculty/amsden/ [email protected]

Anderson, Colin C. U. Alberta AB Stem cells—pancreatic (islet)

Metabolic—diabetes No www.ualberta.ca/~smri/Surgery Research Web Page/DrAnderson.htm

[email protected]

Anderson, Michele Sunnybrook Research Institute U. Toronto ON Stem cells—hematopoietic

Cancer—leukemia, lymphoma

No www.immunology.utoronto.ca/faculty/directory/anderson.htm

[email protected]

Annabi, Borhane U. Québec à Montréal

QC Stem cells—unspecifi ed

Cancer CRC in Molecular Oncology

borhaneannabi.net/index.php?option=com_content&view=section&layout=blog&id=2&Itemid=2

[email protected]

Antel, Jack McGill U. QC Stem cells—adult Neurological—multiple sclerosis

No www.mni.mcgill.ca/neuro_team/cru/jack_antel/ [email protected]

Antoniou, John Jewish General Hospital McGill U. QC Tissue engineering—scaffold; Stem cells—mesenchymal

Musculoskeletal No orthodoc.aaos.org/antoniou/ [email protected]

Aparicio, Samuel BC Cancer Agency U. British Columbia

BC Stem cells—various—hematopoietic, induced pluripotent

Cancer—breast CRC in Molecular Oncology; Nan and Lorraine Robertson Chair

www.pathology.ubc.ca/NewPathology/Professor/Samuel_Aparicio.html

[email protected]

Arora, Rakesh C. Associated with National Research Council of Canada, Institute for Biological Sciences

U. Manitoba MB Stem cells—fat Cardiology No www.sbrc.ca/content/blogcategory/59/93/ [email protected]

Atkins, Harry Sprott Centre for Stem Cell Research, Ottawa Health Research Institute


Various, incl. cancer—hematopoietic, neurological—MS

No www.ohri.ca/profi les/atkins.asp [email protected]

Aubin, Jane U. Toronto ON Stem cells—mesenchymal

Musculoskeletal No medbio.utoronto.ca/faculty/aubin.html [email protected]

Audet, Julie Institute of Biomaterials and Biomedical Engineering

U. Toronto ON Stem cells—hematopoietic

Various No individual.utoronto.ca/julie_audet/ [email protected]

Auger, François A. LOEX U. Laval QC Tissue engineering—cell culture

Various, incl. cardiovascular, transplantation, injury

No www.loex.qc.ca/chercheurs.cv.php?id=2 [email protected]

Bader, Gary Institute of Biomaterials and Biomedical Engineering

U. Toronto ON Stem cells—embryonic Various No www.lunenfeld.ca/researchers/bader [email protected]

LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS33a. Researchers in Alphabetical Order

53

3appendiX3A. RESEARCHERS IN ALPHABETICAL ORDER





Various No lmp.med.ualberta.ca/Admin/Faculty/Pages/default.aspx?P=13

[email protected]

Akimenko, Marie-Andrée Ottawa Hospital Research Institute U. Ottawa ON Regeneration—tissue Musculoskeletal No www.careg.uottawa.ca/bio_marie_andree_akimenko.htm

[email protected]


U. Western Ontario

ON Stem cells—cancer Cancer—breast No www.uwo.ca/anatomy/department/allana/aallan.html [email protected]



Cardiovascular No www.ohri.ca/profi les/allan.asp [email protected]

Alman, Benjamin Hospital for Sick Children U. Toronto ON Stem cells—mesenchymal

Musculoskeletal CRC in Mus-culoskeletal Research; A.J. Latner Profes-sor and Chair of Orthopaedic Surgery

www.sickkids.ca/AboutSickKids/Directory/People/A/Benjamin-Alman-Staff-Profi le.html

[email protected]


Various No chemeng.queensu.ca/people/faculty/amsden/ [email protected]


Metabolic—diabetes No www.ualberta.ca/~smri/Surgery Research Web Page/DrAnderson.htm

[email protected]

Anderson, Michele Sunnybrook Research Institute U. Toronto ON Stem cells—hematopoietic

Cancer—leukemia, lymphoma

No www.immunology.utoronto.ca/faculty/directory/anderson.htm

[email protected]



Cancer CRC in Molecular Oncology

borhaneannabi.net/index.php?option=com_content&view=section&layout=blog&id=2&Itemid=2

[email protected]

Antel, Jack McGill U. QC Stem cells—adult Neurological—multiple sclerosis

No www.mni.mcgill.ca/neuro_team/cru/jack_antel/ [email protected]

Antoniou, John Jewish General Hospital McGill U. QC Tissue engineering—scaffold; Stem cells—mesenchymal

Musculoskeletal No orthodoc.aaos.org/antoniou/ [email protected]



Cancer—breast CRC in Molecular Oncology; Nan and Lorraine Robertson Chair

www.pathology.ubc.ca/NewPathology/Professor/Samuel_Aparicio.html

[email protected]


U. Manitoba MB Stem cells—fat Cardiology No www.sbrc.ca/content/blogcategory/59/93/ [email protected]



Various, incl. cancer—hematopoietic, neurological—MS

No www.ohri.ca/profi les/atkins.asp [email protected]


Musculoskeletal No medbio.utoronto.ca/faculty/aubin.html [email protected]



Various No individual.utoronto.ca/julie_audet/ [email protected]


Various, incl. cardiovascular, transplantation, injury

No www.loex.qc.ca/chercheurs.cv.php?id=2 [email protected]


U. Toronto ON Stem cells—embryonic Various No www.lunenfeld.ca/researchers/bader [email protected]

54

LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS3




Bani, Mahmud Associated with National Research Council of Canada, Institute for Biological Sciences

U. Ottawa ON Stem cells—adult Neurological—brain injury

No www.med.uottawa.ca/NSC/eng/dr_mahmud_bani.html

[email protected]

Barabé, Frédéric U. Laval QC Stem cells—hematopoietic

Cancer—leukemia No www.cri.ulaval.ca/?fbarabe_eng [email protected]

Barber, Dwayne Ontario Cancer Institute, University Health Network


Hematological—anemia, cancer

No www.uhnres.utoronto.ca/researchers/profi le.php?lookup=335

[email protected]

Barralet, Jake McGill U. QC Biomaterials Musculoskeletal—bone formation

CRC in in Osteoinductive Biomaterials

www.mcgill.ca/dentistry/research/barralet/ [email protected]

Barrett, Christopher McGill U. QC Biomaterials Various No www.chemistry.mcgill.ca/directory/people.php?p=9&n=Barrett&t=materials

[email protected]

Baylis, Françoise Dalhousie U. NS Social science & humanities

SSH: Ethics CRC in Bioethics & Philosophy

bioethics.medicine.dal.ca/people/fbaylis.php [email protected]

Beausejour, Christian Hôpital Sainte-Justine (Montréal) U. Montréal QC Stem cells—hematopoietic

Cancer No www.chu-sainte-justine.org/research/chercheurs.aspx?id_nouveau=65947859&id_page=2432&id_menu=2429

[email protected]

Behie, Leo Includes: Pharmaceutical Production Research Facility

U. Calgary AB Bioprocessing—stem cells production/ culture

Various—neurological, metabolic-diabetes

CRC in Biomedical and Biochemical Engineering

schulich.ucalgary.ca/resrch_chem/Chem_Behie.htm [email protected]

Ben-David, Yaacov Sunnybrook Research Institute U. Toronto ON Stem cells—hematopoietic

Cancer—leukemia No medbio.utoronto.ca/faculty/bendavid.html [email protected]

Bennett, Steffany U. Ottawa ON Stem cells—neural Neurological, incl. Alzheimer’s

No www.med.uottawa.ca/bmi/eng/bennett.html [email protected]

Berthod, François LOEX U. Laval QC Tissue engineering—stem cells

Various, incl. neurological, urological, cutaneous

No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/francois-berthod/index.html

[email protected]

Betts, Dean U. Western Ontario

ON Stem cells—pluripotent— induced pluripotent

Various No www.uwo.ca/physpharm/facultyprofi le/betts.html [email protected]

Bhatia, Mickie Stem Cell and Cancer Research Institute

McMaster U. ON Stem cells—various—pluripotent, embryonic, hematopoietic

Various, incl. respiratory—lung disease

CRC in Human Stem Cell Biology; Krembil Chair in Stem Cell Biology

sccri.mcmaster.ca/bhatia_mick.html [email protected]

Biernaskie, Jeffrey A. Associated with Hotchkiss Brain Institute

U. Calgary AB Stem cells—dermal Neurological—injury, wound healing

No www.ucalgary.ca/research4kids/members/biernaskie_full

[email protected]

Bijl, Janetta U. Montréal QC Stem cells—hematopoietic

Cancer—leukemia No recherche.maisonneuve-rosemont.org/en-ca/research/our-research-investigators/bijl-janet.html

[email protected]

Bjerknes, Matthew J. U. Toronto ON Stem cells—gastrointestinal

Gastrointestinal No medbio.utoronto.ca/faculty/bjerknes.html [email protected]

Bramson, Jonathan McMaster U. ON Stem cells—cancer Cancer No fhs.mcmaster.ca/cgt/bramson_jonathan.html [email protected]

Brand, Marjorie Sprott Centre for Stem Cell Research, Ottawa Health Research Institute


Hematological—ß-thalassemia and sickle cell anemia

CRC in the Regulation of Gene Expression

www.ohri.ca/profi les/brand.asp [email protected]

Brash, John McMaster U. ON Biomaterials Various No chemeng.mcmaster.ca/brash.html [email protected]

3a. Cont’d

55






U. Ottawa ON Stem cells—adult Neurological—brain injury

No www.med.uottawa.ca/NSC/eng/dr_mahmud_bani.html

[email protected]


Cancer—leukemia No www.cri.ulaval.ca/?fbarabe_eng [email protected]





[email protected]

Barralet, Jake McGill U. QC Biomaterials Musculoskeletal—bone formation

CRC in in Osteoinductive Biomaterials

www.mcgill.ca/dentistry/research/barralet/ [email protected]

Barrett, Christopher McGill U. QC Biomaterials Various No www.chemistry.mcgill.ca/directory/people.php?p=9&n=Barrett&t=materials

[email protected]


SSH: Ethics CRC in Bioethics & Philosophy

bioethics.medicine.dal.ca/people/fbaylis.php [email protected]

Beausejour, Christian Hôpital Sainte-Justine (Montréal) U. Montréal QC Stem cells—hematopoietic

Cancer No www.chu-sainte-justine.org/research/chercheurs.aspx?id_nouveau=65947859&id_page=2432&id_menu=2429

[email protected]



Various—neurological, metabolic-diabetes

CRC in Biomedical and Biochemical Engineering

schulich.ucalgary.ca/resrch_chem/Chem_Behie.htm [email protected]

Ben-David, Yaacov Sunnybrook Research Institute U. Toronto ON Stem cells—hematopoietic

Cancer—leukemia No medbio.utoronto.ca/faculty/bendavid.html [email protected]

Bennett, Steffany U. Ottawa ON Stem cells—neural Neurological, incl. Alzheimer’s

No www.med.uottawa.ca/bmi/eng/bennett.html [email protected]



No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/francois-berthod/index.html

[email protected]


ON Stem cells—pluripotent— induced pluripotent

Various No www.uwo.ca/physpharm/facultyprofi le/betts.html [email protected]



Various, incl. respiratory—lung disease

CRC in Human Stem Cell Biology; Krembil Chair in Stem Cell Biology

sccri.mcmaster.ca/bhatia_mick.html [email protected]


U. Calgary AB Stem cells—dermal Neurological—injury, wound healing

No www.ucalgary.ca/research4kids/members/biernaskie_full

[email protected]


Cancer—leukemia No recherche.maisonneuve-rosemont.org/en-ca/research/our-research-investigators/bijl-janet.html

[email protected]


Gastrointestinal No medbio.utoronto.ca/faculty/bjerknes.html [email protected]

Bramson, Jonathan McMaster U. ON Stem cells—cancer Cancer No fhs.mcmaster.ca/cgt/bramson_jonathan.html [email protected]



Hematological—ß-thalassemia and sickle cell anemia

CRC in the Regulation of Gene Expression

www.ohri.ca/profi les/brand.asp [email protected]

Brash, John McMaster U. ON Biomaterials Various No chemeng.mcmaster.ca/brash.html [email protected]

56





Brinkman, Ryan Terry Fox Laboratory, BC Cancer Agency

U. British Columbia

BC Stem cells—cancer Cancer No www.terryfoxlab.ca/people/RBrinkman/ryan.aspx [email protected]

Brodt, Pnina The Research Institute of the McGill University Health Centre

McGill U. QC Stem cells—adult—stromal

Cancer No www.mcgill.ca/translational-research-cancer/researcher-biographies/brodt/

[email protected]

Brunette, Donald Biomedical Research Centre U. British Columbia

BC Tissue engineering—biomaterials, stem cells—mesenchymal

Musculoskeletal No www.dentistry.ubc.ca/research/brunette.html [email protected]

Bubela, Tania U. Alberta AB Social science & humanities

SSH: Socioeconomic benefi ts

No www.publichealth.ualberta.ca/en/research/researchers_supersivors/faculty/bubela.aspx

[email protected]

Burt, Helen Mary Biomedical Research Centre U. British Columbia

BC Tissue engineering— biomaterials, stem cells—mesenchymal

Musculoskeletal No https://www.directory.ubc.ca/index.cfm?page=personDetail&row=104080471

[email protected]

Buschmann, Michael École polytechnique de Montréal

QC Biomaterials Musculoskeletal—cartilage cell delivery

CRC in Cartilage Tissue Engineering

www.groupes.polymtl.ca/tissue/en/staff/buschmann.php

[email protected]

Calderone, Angelo Montreal Heart Institute U. Montréal QC Stem cells—neural Cardiology No www.recherche.umontreal.ca/chercheurs_unites/chercheur_affi chage.asp?noseq_chercheur=1596

[email protected]

Cao, Xudong U. Ottawa ON Biomaterials; Tissue engineering—stem cells

Neurological—spinal cord, eye

No www.engineering.uottawa.ca/en/directory/view/xudong_cao/

[email protected]

Carreau, Madeleine Centre hospitalier de l’Université Laval U. Laval QC Stem cells—hematopoietic

Hematological—anemia

No www.crchuq.ulaval.ca/en/research/researchers/8076 [email protected]

Carrier, Patrick LOEX U. Laval QC Stem cells—epithelial (from cornea)

Eye No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/patrick-carrier/index.html

[email protected]

Casper, Robert Samuel Lunenfeld Research Institute, Mount Sinai Hospital


Reproduction—female fertility

No www.obgyn.utoronto.ca/faculty/list/All-Faculty/Casper.htm

[email protected]

Catelas, Isabelle U. Ottawa ON Tissue engineering Musculoskeletal—bone loss

CRC in Bioengineering in Orthopedics

www.engineering.uottawa.ca/en/directory/view/catelas_isabelle/

[email protected]

Caulfi eld, Tim U. Alberta AB Social science & humanities

SSH: Ethics and law CRC in Health Law and Policy

www.law.ualberta.ca/facultystaff/profi les/caulfi eld.php

tcaulfl [email protected]

Cayouette, Michel Institut de recherches cliniques de Montréal

U. Montréal QC Stem cells—neural Neurological, including eye

No www.cenum.umontreal.ca/membres/2_titulaires/en_cayouette_m.html

[email protected]

Chandler, Jennifer U. Ottawa ON Social science & humanities

SSH: Law, policy No www.commonlaw.uottawa.ca/en/jennifer-chandler.html

[email protected]

Chang, Thomas Ming Swi Artifi cial Cells and Organs Research Centre

McGill U. QC Tissue engineering—artifi cial blood cells

Various, incl. cardiovascular

No www.medicine.mcgill.ca/artcell/

www.labome.org/expert/canada/mcgill/chang/thomas-ming-swi-chang-253343.html

[email protected]

Chen, Daniel (Xiongbiao) U. Saskatchewan Sask Tissue engineering—scaffolds

Neurological—peripheral

No www.engr.usask.ca/faculty/Chen_Daniel.php [email protected]

Chen, Jie U. Alberta AB Stem cells—cord blood

Various No www.ece.engineering.ualberta.ca/en/FacultyStaff/FacultyAcademic/JieChen.aspx

[email protected]

Cheng, Hai-Ling Margaret Sunnybrook Research Institute U. Toronto ON Stem cells—unspecifi ed

Neurological—stroke No www.sickkids.ca/AboutSickKids/Directory/People/C/Hai-Ling-Margaret-Cheng-Staff-Profi le.html

[email protected]

Chow, Bob U. Victoria BC Stem cells—retinal Eye CRC in Retinal and Early Eye Development

web.uvic.ca/biology/faculty/facpages/chow.html [email protected]

3a. Cont’d

57






U. British Columbia

BC Stem cells—cancer Cancer No www.terryfoxlab.ca/people/RBrinkman/ryan.aspx [email protected]



Cancer No www.mcgill.ca/translational-research-cancer/researcher-biographies/brodt/

[email protected]

Brunette, Donald Biomedical Research Centre U. British Columbia


Musculoskeletal No www.dentistry.ubc.ca/research/brunette.html [email protected]


SSH: Socioeconomic benefi ts

No www.publichealth.ualberta.ca/en/research/researchers_supersivors/faculty/bubela.aspx

[email protected]

Burt, Helen Mary Biomedical Research Centre U. British Columbia

BC Tissue engineering— biomaterials, stem cells—mesenchymal

Musculoskeletal No https://www.directory.ubc.ca/index.cfm?page=personDetail&row=104080471

[email protected]


QC Biomaterials Musculoskeletal—cartilage cell delivery

CRC in Cartilage Tissue Engineering

www.groupes.polymtl.ca/tissue/en/staff/buschmann.php

[email protected]

Calderone, Angelo Montreal Heart Institute U. Montréal QC Stem cells—neural Cardiology No www.recherche.umontreal.ca/chercheurs_unites/chercheur_affi chage.asp?noseq_chercheur=1596

[email protected]


Neurological—spinal cord, eye

No www.engineering.uottawa.ca/en/directory/view/xudong_cao/

[email protected]

Carreau, Madeleine Centre hospitalier de l’Université Laval U. Laval QC Stem cells—hematopoietic



Carrier, Patrick LOEX U. Laval QC Stem cells—epithelial (from cornea)

Eye No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/patrick-carrier/index.html

[email protected]



Reproduction—female fertility

No www.obgyn.utoronto.ca/faculty/list/All-Faculty/Casper.htm

[email protected]

Catelas, Isabelle U. Ottawa ON Tissue engineering Musculoskeletal—bone loss

CRC in Bioengineering in Orthopedics

www.engineering.uottawa.ca/en/directory/view/catelas_isabelle/

[email protected]


SSH: Ethics and law CRC in Health Law and Policy

www.law.ualberta.ca/facultystaff/profi les/caulfi eld.php

tcaulfl [email protected]


U. Montréal QC Stem cells—neural Neurological, including eye

No www.cenum.umontreal.ca/membres/2_titulaires/en_cayouette_m.html

[email protected]


SSH: Law, policy No www.commonlaw.uottawa.ca/en/jennifer-chandler.html

[email protected]



Various, incl. cardiovascular

No www.medicine.mcgill.ca/artcell/

www.labome.org/expert/canada/mcgill/chang/thomas-ming-swi-chang-253343.html

[email protected]


Neurological—peripheral

No www.engr.usask.ca/faculty/Chen_Daniel.php [email protected]


Various No www.ece.engineering.ualberta.ca/en/FacultyStaff/FacultyAcademic/JieChen.aspx

[email protected]

Cheng, Hai-Ling Margaret Sunnybrook Research Institute U. Toronto ON Stem cells—unspecifi ed

Neurological—stroke No www.sickkids.ca/AboutSickKids/Directory/People/C/Hai-Ling-Margaret-Cheng-Staff-Profi le.html

[email protected]

Chow, Bob U. Victoria BC Stem cells—retinal Eye CRC in Retinal and Early Eye Development

web.uvic.ca/biology/faculty/facpages/chow.html [email protected]

58





Couban, Stephen Dalhousie U. NS Stem cells—cord blood

Cancer—hematological

No dom.medicine.dal.ca/clinicaldivisions/hematology/faculty.htm

[email protected]

Courtman, David Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute

U. Ottawa ON Stem cells—adult—endothelial progenitor

Cardiopulmonary No www.ohri.ca/profi les/courtman.asp [email protected]

Cregan, Sean John P. Robarts Research Institute U. Western Ontario

ON Stem cells—neural Neurological CRC in Neurode-generation and Stem Cell Regen-eration

www.uwo.ca/physpharm/faculty/cregan_sean.html [email protected]

Cross, James Charles U. Calgary AB Stem cells—various—embryonic, trophoblast, placental, germline

Reproduction—female No people.ucalgary.ca/~jcross/homepage.html [email protected]

Crump, Michael A. Ontario Cancer Institute, University Health Network


Cancer—lymphoma No www.uhnresearch.ca/researchers/profi le.php?lookup=1254

[email protected]

Daar, Abdallah McLaughlin-Rotman Centre for Global Health, University Health Network

U. Toronto ON Social science & humanities

SSH: Ethics and law No www.uhnresearch.ca/researchers/profi le.php?lookup=18592

[email protected]

Dankort, David McGill U. QC Stem cells—cancer Cancer No biology.mcgill.ca/faculty/dankort/index.html [email protected]

Davies, John U. Toronto ON Tissue engineering—scaffolds; Stem cells—mesenchymal

Musculoskeletal—bone

No www.utoronto.ca/dentistry/facultyresearch/facultyprofi les/john_davies.html

[email protected]

De Crescenzo, Gregory École polytechnique de Montréal

QC Biomaterials Various—musculoskeletal, cardiovascular

CRC in Protein-Enhanced Biomaterials

www.polymtl.ca/recherche/rc/en/professeurs/details.php?NoProf=302

[email protected]

DeCoteau, John U. Saskatchewan Sask Stem cells—cancer Cancer No www.medicine.usask.ca/pathology/people/faculty/dr-j-decoteau/

[email protected]

Dedhar, Shoukat BC Cancer Agency U. British Columbia

BC Stem cells—mammary Cancer No www.bccrc.ca/dept/ic/genetics/shoukat-dedhar-phd [email protected]

Dekaban, Gregory John P. Robarts Research Institute U. Western Ontario

ON Stem cells—unspecifi ed

Neurological—spinal cord injury

No www.robarts.ca/biotherapeutics/Dekaban.htm [email protected]

Denburg, Judah Aryeh McMaster U. ON Stem cells—hematopoietic

Immunological—allergy, asthma

No fhs.mcmaster.ca/medicine/Immunology_Allergy/faculty_member_denburg.htm

[email protected]

Dennis, James W. Samuel Lunenfeld Research Institute, Mount Sinai Hospital

U. Toronto ON Stem cells—unspecifi ed

Cancer, other CRC in Glycobiology

www.lunenfeld.ca/researchers/dennis [email protected]

Dick, Alexander Sunnybrook Research Institute U. Toronto ON Stem cells—mesenchymal

Cardiology No sunnybrook.ca/research/team/member.asp?t=10&m=53&page=172

[email protected]

Dick, John McEwen Centre for Regenerative Medicine and Ontario Cancer Institute, University Health Network

U. Toronto ON Stem cells—various, incl. hematopoietic

Cancer, incl. leukemia CRC in Stem Cell Biology

www.uhnres.utoronto.ca/researchers/profi le.php?lookup=1468

[email protected]

Dilworth, Jeffrey Sprott Centre for Stem Cell Research, Ottawa Health Research Institute

U. Ottawa ON Stem cells—muscle progenitors

Musculoskeletal: Duchenne

CRC in Epigenetic Regulation of Transcription

www.ohri.ca/profi les/dilworth.asp [email protected]

Dirks, Peter Hospital for Sick Children U. Toronto ON Stem cells—neural Cancer—brain No www.sickkids.ca/AboutSickKids/Directory/People/D/Peter-Dirks.html

[email protected]

Doble, Bradley Stem Cell and Cancer Research Institute

McMaster U. ON Stem cells—embryonic Cancer CRC in Stem Cell Signaling

www.fhs.mcmaster.ca/SCCRI/faculty/doble.html [email protected]

Dobrinski, Ina U. Calgary AB Stem cells—germline—testis

Reproduction—male No www.ucalgary.ca/bmb/dobrinski [email protected]

3a. Cont’d

59







No dom.medicine.dal.ca/clinicaldivisions/hematology/faculty.htm

[email protected]



Cardiopulmonary No www.ohri.ca/profi les/courtman.asp [email protected]

Cregan, Sean John P. Robarts Research Institute U. Western Ontario

ON Stem cells—neural Neurological CRC in Neurode-generation and Stem Cell Regen-eration

www.uwo.ca/physpharm/faculty/cregan_sean.html [email protected]


Reproduction—female No people.ucalgary.ca/~jcross/homepage.html [email protected]



Cancer—lymphoma No www.uhnresearch.ca/researchers/profi le.php?lookup=1254

[email protected]



SSH: Ethics and law No www.uhnresearch.ca/researchers/profi le.php?lookup=18592

[email protected]

Dankort, David McGill U. QC Stem cells—cancer Cancer No biology.mcgill.ca/faculty/dankort/index.html [email protected]

Davies, John U. Toronto ON Tissue engineering—scaffolds; Stem cells—mesenchymal


No www.utoronto.ca/dentistry/facultyresearch/facultyprofi les/john_davies.html

[email protected]


QC Biomaterials Various—musculoskeletal, cardiovascular

CRC in Protein-Enhanced Biomaterials

www.polymtl.ca/recherche/rc/en/professeurs/details.php?NoProf=302

[email protected]

DeCoteau, John U. Saskatchewan Sask Stem cells—cancer Cancer No www.medicine.usask.ca/pathology/people/faculty/dr-j-decoteau/

[email protected]


BC Stem cells—mammary Cancer No www.bccrc.ca/dept/ic/genetics/shoukat-dedhar-phd [email protected]

Dekaban, Gregory John P. Robarts Research Institute U. Western Ontario



No www.robarts.ca/biotherapeutics/Dekaban.htm [email protected]


Immunological—allergy, asthma

No fhs.mcmaster.ca/medicine/Immunology_Allergy/faculty_member_denburg.htm

[email protected]



Cancer, other CRC in Glycobiology

www.lunenfeld.ca/researchers/dennis [email protected]

Dick, Alexander Sunnybrook Research Institute U. Toronto ON Stem cells—mesenchymal

Cardiology No sunnybrook.ca/research/team/member.asp?t=10&m=53&page=172

[email protected]



Cancer, incl. leukemia CRC in Stem Cell Biology


[email protected]



Musculoskeletal: Duchenne

CRC in Epigenetic Regulation of Transcription

www.ohri.ca/profi les/dilworth.asp [email protected]

Dirks, Peter Hospital for Sick Children U. Toronto ON Stem cells—neural Cancer—brain No www.sickkids.ca/AboutSickKids/Directory/People/D/Peter-Dirks.html

[email protected]


McMaster U. ON Stem cells—embryonic Cancer CRC in Stem Cell Signaling

www.fhs.mcmaster.ca/SCCRI/faculty/doble.html [email protected]


Reproduction—male No www.ucalgary.ca/bmb/dobrinski [email protected]

60





Doillon, Charles U. Laval QC Tissue engineering—biomaterials

Various—cardiovascular, cancer


Downey, Gregory U. Toronto ON Regenerative medicine—unspecifi ed

Respiratory CRC in Respiration Sciences

www.utoronto.ca/respirology/who/Gregory_Downey.html

[email protected]

Doyle, John U. Toronto ON Stem cells—hematopoietic

Cancer No www.paeds.utoronto.ca/faculty/doyle.htm [email protected]

Draper, Jonathan Stem Cell and Cancer Research Institute

McMaster U. ON Stem cells—embryonic Various CRC in Human Stem Cell Lineage Commitment

sccri.mcmaster.ca/draper_jon.html [email protected]

Drouin, Jacques Institut de recherches cliniques de Montréal

U. Montréal QC Stem cells—fetal Neurological—Parkinson’s

GlaxoSmithKline Chair in Molecular Genetics

www.ircm.qc.ca/en/recherche/statique/unite27.html [email protected]

Duff, Henry Joseph U. Calgary AB Stem cells—unspecifi ed

Cardiology No cardiacsciences.ucalgary.ca/research/#duff [email protected]

Dufort, Daniel McGill U. QC Stem cells—embryonic Reproduction—implantation

No www.medicine.mcgill.ca/expmed/staff/dufort_daniel.htm

[email protected]

Dumont, Dan Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Various—cardiovascular, cancer

No medbio.utoronto.ca/faculty/dumont.html [email protected]

Duval, Michel U. Montréal QC Stem cells—cord blood

Various No www.chu-sainte-justine.org/research/chercheurs.aspx?ID_nouveau=38393948&id_page=2432&id_menu=2429

[email protected]

Dyck, Richard Henry Associated with Hotchkiss Brain Institute

U. Calgary AB Stem cells—unspecifi ed

Neurological—brain No www.cell.ucalgary.ca/r_dyck.html [email protected]

Eaves, Allen Terry Fox Laboratory, BC Cancer Agency

U. British Columbia

BC Stem cells—hematopoietic

Cancer—leukemia No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.-allen-eaves

[email protected]

Eaves, Connie Terry Fox Laboratory, BC Cancer Agency

U. British Columbia

BC Stem cells—various (embryonic, hematopoietic, breast epithelial)

Cancer No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.-connie-eaves

[email protected]

Egan, Sean Hospital for Sick Children U. Toronto ON Stem cells—mammary epithelial

Cancer—breast No www.sickkids.ca/AboutSickKids/Directory/People/E/Sean-Egan.html

[email protected]

Einsiedel, Edna U. Calgary AB Social science & humanities

SSH: Social science No www.ucalgary.ca/einsiedel/ [email protected]

El-Hakim, Assaad McGill U. QC Tissue engineering—biomaterials, cells

Urological No urology.mcgill.ca/clinicalStaff/associatePart/El-Hakim_A.html

[email protected]

Eliopoulos, Nicoletta Jewish General Hospital, Lady Davis Institute for Medical Research

McGill U. QC Stem cells—mesenchymal

Renal No www.ladydavis.ca/en/nicolettaeliopoulos [email protected]

Elliott, Janet Anne Wade U. Alberta AB Technology—stem cells— cryopreservation

Various CRC in Interfacial Thermodynamics

www.cme.engineering.ualberta.ca/en/FacultyStaff/FacultyAcademicStaff/Elliott.aspx

[email protected]

Ellis, Anne Queen’s U. ON Stem cells—hematopoietic (cord blood)

Immunological—allergy

No microimm.queensu.ca/facultyPages/cross_appointed/ellis.html

[email protected]

Ellis, James Hospital for Sick Children U. Toronto ON Stem cells—pluripotent—embryonic, induced pluripotent

Various, incl. neurological, incl. Rett’s; hematological—anemia

No www.sickkids.ca/Research/Ellis-Lab/index.html [email protected]

3a. Cont’d

61






Various—cardiovascular, cancer



Respiratory CRC in Respiration Sciences

www.utoronto.ca/respirology/who/Gregory_Downey.html

[email protected]


Cancer No www.paeds.utoronto.ca/faculty/doyle.htm [email protected]


McMaster U. ON Stem cells—embryonic Various CRC in Human Stem Cell Lineage Commitment

sccri.mcmaster.ca/draper_jon.html [email protected]



GlaxoSmithKline Chair in Molecular Genetics

www.ircm.qc.ca/en/recherche/statique/unite27.html [email protected]


Cardiology No cardiacsciences.ucalgary.ca/research/#duff [email protected]

Dufort, Daniel McGill U. QC Stem cells—embryonic Reproduction—implantation

No www.medicine.mcgill.ca/expmed/staff/dufort_daniel.htm

[email protected]

Dumont, Dan Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Various—cardiovascular, cancer

No medbio.utoronto.ca/faculty/dumont.html [email protected]


Various No www.chu-sainte-justine.org/research/chercheurs.aspx?ID_nouveau=38393948&id_page=2432&id_menu=2429

[email protected]



Neurological—brain No www.cell.ucalgary.ca/r_dyck.html [email protected]


U. British Columbia


Cancer—leukemia No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.-allen-eaves

[email protected]


U. British Columbia


Cancer No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.-connie-eaves

[email protected]

Egan, Sean Hospital for Sick Children U. Toronto ON Stem cells—mammary epithelial

Cancer—breast No www.sickkids.ca/AboutSickKids/Directory/People/E/Sean-Egan.html

[email protected]


SSH: Social science No www.ucalgary.ca/einsiedel/ [email protected]


Urological No urology.mcgill.ca/clinicalStaff/associatePart/El-Hakim_A.html

[email protected]



Renal No www.ladydavis.ca/en/nicolettaeliopoulos [email protected]


Various CRC in Interfacial Thermodynamics

www.cme.engineering.ualberta.ca/en/FacultyStaff/FacultyAcademicStaff/Elliott.aspx

[email protected]


Immunological—allergy

No microimm.queensu.ca/facultyPages/cross_appointed/ellis.html

[email protected]

Ellis, James Hospital for Sick Children U. Toronto ON Stem cells—pluripotent—embryonic, induced pluripotent

Various, incl. neurological, incl. Rett’s; hematological—anemia

No www.sickkids.ca/Research/Ellis-Lab/index.html [email protected]

62





Emery, Gregory U. Montréal QC Stem cells—unspecifi ed

Cancer No www.iric.ca/Recherche/Unites_Recherche/Signalisation_vesiculaire.htm

[email protected]

Emili, Andrew The Donnelly Centre—Banting and Best Department of Medical Research

U. Toronto ON Stem cells—embryonic Cancer No lambda.med.utoronto.ca/Emili.htm [email protected]

Farhat, Walid Hospital for Sick Children U. Toronto ON Tissue engineering —cells, scaffold

Urological No www.sickkids.ca/AboutSickKids/Directory/People/F/Walid-Farhat-landing-page.html

[email protected]

Farookhi, Riaz McGill U. QC Stem cells—ovarian epithelial

Reproduction—ovary No www.medicine.mcgill.ca/physio/staffpages/rfarookhi.htm

[email protected]

Faucheux, Nathalie U. Sherbrooke QC Biomaterials—scaffolds

Musculoskeletal—bone and cartilage regeneration

CRC in Cell-Biomaterial Biohybrid Systems

www.usherbrooke.ca/gchimiquebiotech/personnel/professeurs/nathalie-faucheux/

[email protected]

Favis, Basil École polytechnique de Montréal

QC Biomaterials—scaffolds

Various No www.polymtl.ca/recherche/rc/en/professeurs/details.php?NoProf=30&showtab=PUB

[email protected]

Fehlings, Michael McEwen Centre for Regenerative Medicine and McLaughlin Centre for Molecular Medicine, Toronto Western Research Institute, University Health Network

U. Toronto ON Stem cells—neural Neurological—spinal cord injury

No www.uhnresearch.ca/researchers/profi le.php?lookup=1781

[email protected]

Ferguson, Peter Charles Mount Sinai Hospital U. Toronto ON Stem cells—mesenchymal stromal

Musculoskeletal No orthopaedics.utoronto.ca/faculty/list/ferguson.htm [email protected]

Fernandes, Karl U. Montréal QC Stem cells—neural Neurological—neurodegenerative diseases, incl. Alzheimer’s

CRC in Stem Cell Neurobiology

www.cenum.umontreal.ca/membres/2_titulaires/en_fernandes_k.html

[email protected]

Fernlund, Goran U. British Columbia


Musculoskeletal No www.mtrl.ubc.ca/faculty_&_staff/fernlund.php [email protected]

Figeys, Daniel U. Ottawa ON Stem cells—cell handling

Various No www.med.uottawa.ca/bmi/eng/fi geys.html dfi [email protected]

Filiaggi, Mark J. Dalhousie U. NS Biomaterials Musculoskeletal—bone

No faculty-server.dentistry.dal.ca/datasystems/faculty_website/Faculty_Staff_details.php?name=Mark_Filiaggi&section=presentations

fi [email protected]

Flynn, Lauren Queen’s U. ON Stem cells—fat; Tissue engineering—scaffolds

Various No chemeng.queensu.ca/people/faculty/fl ynn/index.php lauren.fl [email protected]

Fradette, Julie LOEX U. Laval QC Stem cells—fat; Tissue engineering

Musculoskeletal No www.loex.gc.ca [email protected]

Frei, Hanspeter Carleton U. ON Stem cells—mesenchymal


No research.mae.carleton.ca/Faculty.html [email protected]

Garnier, Alain U. Laval QC Bioprocessing—stem cells—culture

Various No www.gch.ulaval.ca/agarnier/ [email protected]

Gassas, Adam Hospital for Sick Children U. Toronto ON Stem cells—hematopoietic

Cancer—leukemia No www.sickkids.ca/Research/LRG/LRG-members/dr-adam-gassas/index.html

[email protected]

Germain, Lucie LOEX U. Laval QC Stem cells—adult—epithelial

Various, incl. cutaneous, cardiovascular, eye

CRC in Stem Cell and Tissue Engineering

www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/lucie-germain/index.html

[email protected]

3a. Cont’d

63






Cancer No www.iric.ca/Recherche/Unites_Recherche/Signalisation_vesiculaire.htm

[email protected]


U. Toronto ON Stem cells—embryonic Cancer No lambda.med.utoronto.ca/Emili.htm [email protected]

Farhat, Walid Hospital for Sick Children U. Toronto ON Tissue engineering —cells, scaffold

Urological No www.sickkids.ca/AboutSickKids/Directory/People/F/Walid-Farhat-landing-page.html

[email protected]


Reproduction—ovary No www.medicine.mcgill.ca/physio/staffpages/rfarookhi.htm

[email protected]


Musculoskeletal—bone and cartilage regeneration

CRC in Cell-Biomaterial Biohybrid Systems

www.usherbrooke.ca/gchimiquebiotech/personnel/professeurs/nathalie-faucheux/

[email protected]



Various No www.polymtl.ca/recherche/rc/en/professeurs/details.php?NoProf=30&showtab=PUB

[email protected]


U. Toronto ON Stem cells—neural Neurological—spinal cord injury


[email protected]


Musculoskeletal No orthopaedics.utoronto.ca/faculty/list/ferguson.htm [email protected]

Fernandes, Karl U. Montréal QC Stem cells—neural Neurological—neurodegenerative diseases, incl. Alzheimer’s

CRC in Stem Cell Neurobiology

www.cenum.umontreal.ca/membres/2_titulaires/en_fernandes_k.html

[email protected]



Musculoskeletal No www.mtrl.ubc.ca/faculty_&_staff/fernlund.php [email protected]

Figeys, Daniel U. Ottawa ON Stem cells—cell handling

Various No www.med.uottawa.ca/bmi/eng/fi geys.html dfi [email protected]

Filiaggi, Mark J. Dalhousie U. NS Biomaterials Musculoskeletal—bone

No faculty-server.dentistry.dal.ca/datasystems/faculty_website/Faculty_Staff_details.php?name=Mark_Filiaggi&section=presentations

fi [email protected]


Various No chemeng.queensu.ca/people/faculty/fl ynn/index.php lauren.fl [email protected]


Musculoskeletal No www.loex.gc.ca [email protected]



No research.mae.carleton.ca/Faculty.html [email protected]


Various No www.gch.ulaval.ca/agarnier/ [email protected]

Gassas, Adam Hospital for Sick Children U. Toronto ON Stem cells—hematopoietic

Cancer—leukemia No www.sickkids.ca/Research/LRG/LRG-members/dr-adam-gassas/index.html

[email protected]


Various, incl. cutaneous, cardiovascular, eye

CRC in Stem Cell and Tissue Engineering

www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/lucie-germain/index.html

[email protected]

64





Geyer, Ronald U. Saskatchewan Sask Stem cells—cancer Cancer No www.saskcancer.ca/Default.aspx?DN=a7fb7a71-3960-4787-b700-e2925d8a7c8a

N/A

Ghanekar, Anand U. Toronto ON Stem cells—cancer Cancer—liver No www.uhnres.utoronto.ca/researchers/profi le.php?lookup=2011

[email protected]

Ghanem, Amyl Dalhousie U. NS Biomaterials—tissue engineering

Various No chemicalengineering.dal.ca/Faculty/Research/Dr._A._Ghanem_.php

[email protected]

Giacomantonio, Carman A. Dalhousie U. NS Stem cells—cancer Cancer No generalsurgery.medicine.dal.ca/faculty.htm#Giacomantonio

N/A

Giasson, Claude J. LOEX affi liation U. Montréal QC Tissue engineering Eye No mapageweb.umontreal.ca/giassonc/ [email protected]

Glass, Kathleen McGill U. QC Social science & humanities

SSH: Ethics, legal No www.mcgill.ca/biomedicalethicsunit/faculty/glass/ [email protected]

Golding, Michael C. U. Western Ontario (moved to Texas A&M U. June 2010)

ON Stem cells—various—unspecifi ed

Embryogenesis No vetmed.tamu.edu/vtpp/directorydetail?userid=9942; vetmed.tamu.edu/rsl/faculty/michael-golding

N/A

Goulet, Francine LOEX U. Laval QC Tissue engineering—biomaterials, culture

Musculoskeletal No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/francine-goulet/index.html

[email protected]

Gramolini, Anthony Orlando The Donnelly Centre, Banting and Best Department of Medical Research


Cardiovascular CRC in Cardiovascular Proteomics and Molecular Therapeutics

www.physiology.utoronto.ca/res/list/gramolini.htm [email protected]

Grant, Denis U. Toronto ON Stem cells—pluripotent—embryonic, induced pluripotent

Cancer No www.pharmtox.utoronto.ca/faculty/directory/grant.htm

[email protected]

Greenblatt, Jack The Donnelly Centre, Banting and Best Department of Medical Research


Various No tdccbr.med.utoronto.ca/members/jack_greenblatt.html

[email protected]

Gregory-Evan, Kevin Vancouver Coastal Health Research Institute

U. British Columbia

BC Stem cells—embryonic Eye Julia Levy B.C. Leadership Chair in Macular Research

www.ophthalmology.ubc.ca/faculty_pages/k-gregory-evans.html

[email protected]

Grenier, Guillaume U. Sherbrooke QC Stem cells—muscle progenitors

Musculoskeletal—muscle

No www.usherbrooke.ca/departement-chirurgie/francais/recherche/professeurs-ayant-une-activite-de-recherche/fi ches-de-professeurs/guillaume

[email protected]

Griffi th, May Sprott Centre for Stem Cell Research, Ottawa Health Research Institute

U. Ottawa ON Biomaterials—scaffolds; Tissue engineering—stem cells

Eye No www.ohri.ca/profi les/griffi th.asp mgriffi [email protected]

Guidos, Cynthia Hospital for Sick Children U. Toronto ON Stem cells—hematopoietic

Cancer—leukemia No www.sickkids.ca/Research/Guidos-Lab/index.html [email protected]

Gutkowska, Jolanta Centre de recherche du Centre hospitalier de l’Université de Montréal

U. Montréal QC Stem cells—embryonic Cardiology No chumtl.qc.ca/crchum/chercheurs/chercheurs-liste/gutkowska-j.en.html?mode=print

[email protected]

Hamilton, Douglas U. Western Ontario

ON Biomaterials; Tissue engineering

Dental No www.uwo.ca/anatomy/department/hamiltond/dhamilton.html

[email protected]

Hansen, David U. Calgary AB Stem cells—unspecifi ed

Various No homepages.ucalgary.ca/~dhansen/ [email protected]

3a. Cont’d

65





Geyer, Ronald U. Saskatchewan Sask Stem cells—cancer Cancer No www.saskcancer.ca/Default.aspx?DN=a7fb7a71-3960-4787-b700-e2925d8a7c8a

N/A

Ghanekar, Anand U. Toronto ON Stem cells—cancer Cancer—liver No www.uhnres.utoronto.ca/researchers/profi le.php?lookup=2011

[email protected]


Various No chemicalengineering.dal.ca/Faculty/Research/Dr._A._Ghanem_.php

[email protected]

Giacomantonio, Carman A. Dalhousie U. NS Stem cells—cancer Cancer No generalsurgery.medicine.dal.ca/faculty.htm#Giacomantonio

N/A

Giasson, Claude J. LOEX affi liation U. Montréal QC Tissue engineering Eye No mapageweb.umontreal.ca/giassonc/ [email protected]


SSH: Ethics, legal No www.mcgill.ca/biomedicalethicsunit/faculty/glass/ [email protected]

Golding, Michael C. U. Western Ontario (moved to Texas A&M U. June 2010)

ON Stem cells—various—unspecifi ed

Embryogenesis No vetmed.tamu.edu/vtpp/directorydetail?userid=9942; vetmed.tamu.edu/rsl/faculty/michael-golding

N/A


Musculoskeletal No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/francine-goulet/index.html

[email protected]



Cardiovascular CRC in Cardiovascular Proteomics and Molecular Therapeutics

www.physiology.utoronto.ca/res/list/gramolini.htm [email protected]


Cancer No www.pharmtox.utoronto.ca/faculty/directory/grant.htm

[email protected]



Various No tdccbr.med.utoronto.ca/members/jack_greenblatt.html

[email protected]


U. British Columbia

BC Stem cells—embryonic Eye Julia Levy B.C. Leadership Chair in Macular Research

www.ophthalmology.ubc.ca/faculty_pages/k-gregory-evans.html

[email protected]



No www.usherbrooke.ca/departement-chirurgie/francais/recherche/professeurs-ayant-une-activite-de-recherche/fi ches-de-professeurs/guillaume

[email protected]



Eye No www.ohri.ca/profi les/griffi th.asp mgriffi [email protected]

Guidos, Cynthia Hospital for Sick Children U. Toronto ON Stem cells—hematopoietic

Cancer—leukemia No www.sickkids.ca/Research/Guidos-Lab/index.html [email protected]


U. Montréal QC Stem cells—embryonic Cardiology No chumtl.qc.ca/crchum/chercheurs/chercheurs-liste/gutkowska-j.en.html?mode=print

[email protected]



Dental No www.uwo.ca/anatomy/department/hamiltond/dhamilton.html

[email protected]


Various No homepages.ucalgary.ca/~dhansen/ [email protected]

66





Harvey, Edward McGill U. QC Biomaterials; Tissue engineering—cells


No www.medicine.mcgill.ca/orthopaedics/faculty.htm [email protected]

Hassell, John McMaster U. ON Stem cells—adult, cancer

Cancer No www.biology.mcmaster.ca/faculty/hassell/hassell.htm

[email protected]

Hawke, Thomas McMaster U. ON Stem cells—muscle progenitor


No fhs.mcmaster.ca/pathology/contact_us/faculty/faculty_bios/Hawke_000.html

[email protected]

Hazell, Alan Stewart Centre de recherché du Centre hospitalier de l’Université de Montréal

U. Montréal QC Stem cells—neural Neurological—brain injury

No www.chumtl.qc.ca/crchum/chercheurs/chercheurs-liste/hazell-as.en.html

[email protected]

Hebert, Marie-Josee Centre de recherche du Centre hospitalier de l’Université de Montréal

U. Montréal QC Stem cells—mesenchymal

Various—renal, cardiovascular

No www.chumtl.qc.ca/crchum/chercheurs/chercheurs-liste/hebert-mj.fr.html

[email protected]

Hedley, David William Ontario Cancer Institute, University Health Network

U. Toronto ON Stem cells—cancer Cancer—cervical No www.uhnres.utoronto.ca/researchers/profi le.php?lookup=2395

[email protected]

Helgason, Cheryl BC Cancer Agency U. British Columbia

BC Stem cells—embryonic Immunological—autoimmune

No www.bccrc.ca/dept/et/personnel - content/senior-scientists/cheryl-helgason

[email protected]

Hess, David John P. Robarts Research Institute U. Western Ontario

ON Stem cells—bone marrow (mesenchymal, hematopoietic)

Various—cardiovascular; Metabolic—diabetes

No www.robarts.ca/david-hess [email protected]

Heveker, Nikolaus Hôpital Sainte-Justine U. Montréal QC Stem cells—hematopoietic

Various No www.chu-sainte-justine.org/research/chercheurs.aspx?ID_NOUVEAU=35430911&id_page=2432&id_menu=2429

[email protected]

Hicks, Geoffrey Cancer Care Manitoba—Institute of Cell Biology

U. Manitoba MB Stem cells—embryonic Cancer CRC in Functional Genomics

www.umanitoba.ca/institutes/manitoba_institute_cell_biology/MICB/hicks_geoff.htm

[email protected]

Hill, David Lawson Health Research Institute, London Health Sciences Centre

U. Western Ontario

ON Stem cells—adult Metabolic—diabetes No www.uwo.ca/physpharm/faculty/hill_david.html [email protected]

Hill, Richard Ontario Cancer Institute, University Health Network


[email protected]

Hoang, Trang Institute for Research in Immunology and Cancer

U. Montréal QC Stem cells—hematopoietic

Cancer—leukemia CRC in Cell Differentiation and the Genetics of Acute Leukemias

www.iric.ca/Recherche/Chercheurs/Hoang_T.html [email protected]

Hoare, Todd McMaster U. ON Biomaterials Various No chemeng.mcmaster.ca/hoare.html [email protected]

Hoemann, Caroline École polytechnique de Montréal

QC Tissue engineering—cells; Biomaterials

Musculoskeletal No www.polymtl.ca/recherche/rc/en/professeurs/details.php?NoProf=347

[email protected]

Hogge, Donna Terry Fox Laboratory, BC Cancer Agency

U. British Columbia


Cancer—leukemia No www.bccrc.ca/dept/terry-fox-laboratory/faculty/Hogge

[email protected]

Hombach-Klonisch, Sabine U. Manitoba MB Stem cells—cancer Cancer No www.umanitoba.ca/faculties/medicine/units/anatomy/hombachks.html

[email protected]

Hoodless, Pamela Terry Fox Laboratory, BC Cancer Agency

U. British Columbia

BC Stem cells—embryonic Embryogenesis No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.-pamela-hoodless-phd

[email protected]

Hope, Kristin Jill Stem Cell and Cancer Research Institute

McMaster U. ON Stem cells—hematopoietic

Cancer—leukemia No sccri.mcmaster.ca/hope_kristin.html [email protected]

Horb, Markoe Institut de recherches cliniques de Montréal

U. Montréal QC Stem cells—adult—endodermal progenitors

Metabolic—diabetes No www.montreal-diabetes-research-center.org/en/horb/horb.asp

[email protected]

3a. Cont’d

67







No www.medicine.mcgill.ca/orthopaedics/faculty.htm [email protected]


Cancer No www.biology.mcmaster.ca/faculty/hassell/hassell.htm

[email protected]



No fhs.mcmaster.ca/pathology/contact_us/faculty/faculty_bios/Hawke_000.html

[email protected]

Hazell, Alan Stewart Centre de recherché du Centre hospitalier de l’Université de Montréal

U. Montréal QC Stem cells—neural Neurological—brain injury

No www.chumtl.qc.ca/crchum/chercheurs/chercheurs-liste/hazell-as.en.html

[email protected]



Various—renal, cardiovascular

No www.chumtl.qc.ca/crchum/chercheurs/chercheurs-liste/hebert-mj.fr.html

[email protected]



[email protected]


BC Stem cells—embryonic Immunological—autoimmune

No www.bccrc.ca/dept/et/personnel - content/senior-scientists/cheryl-helgason

[email protected]

Hess, David John P. Robarts Research Institute U. Western Ontario


Various—cardiovascular; Metabolic—diabetes

No www.robarts.ca/david-hess [email protected]


Various No www.chu-sainte-justine.org/research/chercheurs.aspx?ID_NOUVEAU=35430911&id_page=2432&id_menu=2429

[email protected]


U. Manitoba MB Stem cells—embryonic Cancer CRC in Functional Genomics

www.umanitoba.ca/institutes/manitoba_institute_cell_biology/MICB/hicks_geoff.htm

[email protected]


U. Western Ontario

ON Stem cells—adult Metabolic—diabetes No www.uwo.ca/physpharm/faculty/hill_david.html [email protected]



[email protected]



Cancer—leukemia CRC in Cell Differentiation and the Genetics of Acute Leukemias

www.iric.ca/Recherche/Chercheurs/Hoang_T.html [email protected]

Hoare, Todd McMaster U. ON Biomaterials Various No chemeng.mcmaster.ca/hoare.html [email protected]



Musculoskeletal No www.polymtl.ca/recherche/rc/en/professeurs/details.php?NoProf=347

[email protected]


U. British Columbia


Cancer—leukemia No www.bccrc.ca/dept/terry-fox-laboratory/faculty/Hogge

[email protected]

Hombach-Klonisch, Sabine U. Manitoba MB Stem cells—cancer Cancer No www.umanitoba.ca/faculties/medicine/units/anatomy/hombachks.html

[email protected]


U. British Columbia

BC Stem cells—embryonic Embryogenesis No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.-pamela-hoodless-phd

[email protected]



Cancer—leukemia No sccri.mcmaster.ca/hope_kristin.html [email protected]



Metabolic—diabetes No www.montreal-diabetes-research-center.org/en/horb/horb.asp

[email protected]

68





Hough, Margaret Sunnybrook Research Institute U. Toronto ON Stem cells—various—embryonic, hematopoietic

Genetic No sunnybrook.ca/research/team/member.asp?t=11&m=83&page=172

margaret.hough@ sri.utoronto.ca

Huang, Annie Hospital for Sick Children U. Toronto ON Stem cells—neural Cancer—brain No www.sickkids.ca/AboutSickKids/Directory/People/H/Annie-A-Huang.html

[email protected]

Huang, Sui U. Calgary AB Stem cells—embryonic Hematological No www.bio.ucalgary.ca/contact/faculty/huang.html [email protected]

Hughes, Timothy The Donnelly Centre—Banting and Best Department of Medical Research

U. Toronto ON Stem cells—embryonic Various No hugheslab.med.utoronto.ca/ [email protected]

Hui, Chi-chung Hospital for Sick Children U. Toronto ON Stem cells—various—unspecifi ed

Neurological No www.sickkids.ca/AboutSickKids/Directory/People/H/Chi-chung-Hu.html

[email protected]

Humphries, Keith Terry Fox Laboratory, BC Cancer Agency

U. British Columbia



No www.terryfoxlab.ca/people/khumphries/keith.aspx [email protected]

Hunter, Christopher U. Calgary AB Tissue engineering—stem cells; Biomaterials

Musculoskeletal—disc No www.eng.ucalgary.ca/resrch_mech/Mech_Hunter.htm

[email protected]

Husain, Mansoor McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network

U. Toronto ON Stem cells—embryonic Cardiovascular No uhnres.utoronto.ca/researchers/profi le.php?lookup=2610

[email protected]

Illes, Judy U. British Columbia

BC Social science & humanities

SSH: Ethics CRCin Neuroethics

www.neuroethics.ubc.ca/National_Core_for_Neuroethics/People.html

[email protected]

Ingram, Liz U. Alberta AB Social science & humanities

SSH: Social No www.artdesign.ualberta.ca/Faculty_and_Staff/Faculty/Liz_Ingram.aspx

[email protected]

Iscove, Norman McEwen Centre for Regenerative Medicine, and Ontario Cancer Institute, University Health Network


Cancer—leukemia No www.uhnresearch.ca/researchers/profi le.php?lookup=2679

[email protected]

Jackson, Michael U. Manitoba MB Stem cells—bone marrow

Cardiology No www.umanitoba.ca/faculties/medicine/units/pharmacology/faculty_members/index.html

N/A

Jervis, Eric U. Waterloo ON Bioprocessing—cell culture; Tissue engineering

Various No chemeng.uwaterloo.ca/faculty/jervis.html [email protected]

Jiang, Xiaoyan Terry Fox Laboratory, BC Cancer Agency

U. British Columbia


Cancer—leukemia No www.terryfoxlab.ca/people/XJiang/xiaoyan.aspx [email protected]

Jirik, Frank Southern Alberta Cancer Research Institute

U. Calgary AB Stem cells—adult Cancer No www.sacri.ucalgary.ca/node/158 [email protected]

Johnson, James U. British Columbia

BC Stem cells—pancreatic (islet)

Metabolic—diabetes No www.cellphys.ubc.ca/faculty_pages/johnson.html [email protected]

Johnston, James U. Saskatchewan Sask Tissue engineering—scaffolds

Musculoskeletal No www.engr.usask.ca/faculty/Johnston_James.php [email protected]

Jolicoeur, Mario École polytechnique de Montréal

QC Bioprocessing Various CRC in Applied Metabolic Engineering

www.polymtl.ca/bio-p2/ [email protected]

Jolicoeur, Paul Institut de recherches cliniques de Montréal

U. Montréal QC Stem cells—various—cancer/mammary

Cancer CRC in in Studies of Pathogenesis of Retrovirus—Induced Diseases

en.wikipedia.org/wiki/Paul_Jolicoeur www.ircm.qc.ca/fr/recherche/statique/unite4.html

[email protected]

Jones, Elizabeth McGill U. QC Tissue engineering Cardiovascular CRC in Embryonic Biomechanics

people.mcgill.ca/elizabeth.jones3/ [email protected]

3a. Cont’d

69





Hough, Margaret Sunnybrook Research Institute U. Toronto ON Stem cells—various—embryonic, hematopoietic

Genetic No sunnybrook.ca/research/team/member.asp?t=11&m=83&page=172

margaret.hough@ sri.utoronto.ca

Huang, Annie Hospital for Sick Children U. Toronto ON Stem cells—neural Cancer—brain No www.sickkids.ca/AboutSickKids/Directory/People/H/Annie-A-Huang.html

[email protected]

Huang, Sui U. Calgary AB Stem cells—embryonic Hematological No www.bio.ucalgary.ca/contact/faculty/huang.html [email protected]


U. Toronto ON Stem cells—embryonic Various No hugheslab.med.utoronto.ca/ [email protected]

Hui, Chi-chung Hospital for Sick Children U. Toronto ON Stem cells—various—unspecifi ed

Neurological No www.sickkids.ca/AboutSickKids/Directory/People/H/Chi-chung-Hu.html

[email protected]


U. British Columbia



No www.terryfoxlab.ca/people/khumphries/keith.aspx [email protected]


Musculoskeletal—disc No www.eng.ucalgary.ca/resrch_mech/Mech_Hunter.htm

[email protected]


U. Toronto ON Stem cells—embryonic Cardiovascular No uhnres.utoronto.ca/researchers/profi le.php?lookup=2610

[email protected]



SSH: Ethics CRCin Neuroethics

www.neuroethics.ubc.ca/National_Core_for_Neuroethics/People.html

[email protected]


SSH: Social No www.artdesign.ualberta.ca/Faculty_and_Staff/Faculty/Liz_Ingram.aspx

[email protected]




[email protected]


Cardiology No www.umanitoba.ca/faculties/medicine/units/pharmacology/faculty_members/index.html

N/A


Various No chemeng.uwaterloo.ca/faculty/jervis.html [email protected]


U. British Columbia


Cancer—leukemia No www.terryfoxlab.ca/people/XJiang/xiaoyan.aspx [email protected]


U. Calgary AB Stem cells—adult Cancer No www.sacri.ucalgary.ca/node/158 [email protected]



Metabolic—diabetes No www.cellphys.ubc.ca/faculty_pages/johnson.html [email protected]


Musculoskeletal No www.engr.usask.ca/faculty/Johnston_James.php [email protected]


QC Bioprocessing Various CRC in Applied Metabolic Engineering

www.polymtl.ca/bio-p2/ [email protected]



Cancer CRC in in Studies of Pathogenesis of Retrovirus—Induced Diseases

en.wikipedia.org/wiki/Paul_Jolicoeur www.ircm.qc.ca/fr/recherche/statique/unite4.html

[email protected]

Jones, Elizabeth McGill U. QC Tissue engineering Cardiovascular CRC in Embryonic Biomechanics

people.mcgill.ca/elizabeth.jones3/ [email protected]

70





Jones, Kim McMaster U. ON Biomaterials Various, incl. immunological

No chemeng.mcmaster.ca/jones.html [email protected]

Joshi, Sadhna U. Toronto ON Stem cells—hematopoietic

Infection—HIV No www.utoronto.ca/idmicro/ [email protected]

Julius, Michael Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Various, incl. immunological, cancer, infection

No www.immunology.utoronto.ca/faculty/directory/julius.htm

[email protected]

Kaern, Mads U. Ottawa ON Stem cells—embryonic Various CRC in Systems Biology

www.med.uottawa.ca/Associations/OISB/members/member_mads_kaern.htm

[email protected]

Kallos, Michael Includes: Pharmaceutical Production Research Facility

U. Calgary AB Bioprocessing—stem cells, tissue culture

Various No schulich.ucalgary.ca/resrch_chem/Chem_Kallos.htm [email protected]

Kamacheva, Eugenia U. Toronto ON Biomaterials Various No www.chem.utoronto.ca/staff/EK/index.htm [email protected]

Kamnasaran, Deepak U. Laval QC Stem cells—cancer Cancer—brain No kamnasaran.yolasite.com/ [email protected]

Kandel, Rita Samuel Lunenfeld Research Institute, Mount Sinai Hospital

U. Toronto ON Tissue engineering—biomaterials, stem cells

Musculoskeletal No www.lunenfeld.ca/researchers/kandel [email protected]

Kaplan, David Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer CRC in in Cancer and Neuroscience

www.sickkids.ca/AboutSickKids/Directory/People/K/David-Kaplan.html

[email protected]

Karimi-Abdolrezaee, Soheila U. Manitoba MB Stem cells—neural Neurological—spinal cord injury

No www.mich.ca/index.php?page=9&id=64 [email protected]

Karsan, Aly BC Cancer Agency U. British Columbia


Cancer—leukemia No www.bccrc.ca/dept/cmsgsc/faculty/dr-aly-karsan-md/?searchterm=Karsan

[email protected]

Keating, Armand U. Toronto ON Stem cells—bone marrow—mesenchymal, hematopoietic


Epstein Chair in Cell Therapy and Transplantation

www.armandkeating.com [email protected]

Keeley, Fred Hospital for Sick Children U. Toronto ON Biomaterials Cardiovascular Heart and Stroke Foundation of Ontario—Robert M. Freedom Chair in Cardiovascular Science

www.sickkids.ca/AboutSickKids/Directory/People/K/Frederick-Keeley-staff-profi le.html

[email protected]

Keller, Gordon McEwen Centre for Regenerative Medicine and Ontario Cancer Institute, University Health Network

U. Toronto ON Stem cells—embryonic Various, incl. hematological, cardiovascular

CRC in Embryonic Stem Cell Biology

www.uhn.ca/donate/tgwh/site/mcewen/bio_keller.asp

[email protected]

Kelly, Kevin Francis Stem Cell and Cancer Research Institute

McMaster U. ON Stem cells—embryonic Various, incl. cutaneous, cancer

No sccri.mcmaster.ca/kelly_kevin.html [email protected]

Khan, Zia U. Western Ontario

ON Stem cells—vascular Various No www.uwo.ca/pathol/faculty/khan.html [email protected]

Kieffer, Tim U. British Columbia

BC Stem cells—gastrointestinal

Metabolic—diabetes No www.cellphys.ubc.ca/faculty_pages/kieffer.html [email protected]

Kim, Seung Vancouver Coastal Health Research Institute

U. British Columbia

BC Stem cells—neural Neurological No www.brain.ubc.ca/people.htm#K [email protected]

Kislinger, Thomas Ontario Cancer Institute, UHN U. Toronto ON Stem cells—unspecifi ed

Cardiovascular No www.uhnres.utoronto.ca/researchers/profi le.php?lookup=12469

[email protected]

3a. Cont’d

71





Jones, Kim McMaster U. ON Biomaterials Various, incl. immunological

No chemeng.mcmaster.ca/jones.html [email protected]


Infection—HIV No www.utoronto.ca/idmicro/ [email protected]

Julius, Michael Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Various, incl. immunological, cancer, infection

No www.immunology.utoronto.ca/faculty/directory/julius.htm

[email protected]

Kaern, Mads U. Ottawa ON Stem cells—embryonic Various CRC in Systems Biology

www.med.uottawa.ca/Associations/OISB/members/member_mads_kaern.htm

[email protected]



Various No schulich.ucalgary.ca/resrch_chem/Chem_Kallos.htm [email protected]

Kamacheva, Eugenia U. Toronto ON Biomaterials Various No www.chem.utoronto.ca/staff/EK/index.htm [email protected]

Kamnasaran, Deepak U. Laval QC Stem cells—cancer Cancer—brain No kamnasaran.yolasite.com/ [email protected]



Musculoskeletal No www.lunenfeld.ca/researchers/kandel [email protected]

Kaplan, David Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer CRC in in Cancer and Neuroscience

www.sickkids.ca/AboutSickKids/Directory/People/K/David-Kaplan.html

[email protected]

Karimi-Abdolrezaee, Soheila U. Manitoba MB Stem cells—neural Neurological—spinal cord injury

No www.mich.ca/index.php?page=9&id=64 [email protected]



Cancer—leukemia No www.bccrc.ca/dept/cmsgsc/faculty/dr-aly-karsan-md/?searchterm=Karsan

[email protected]



Epstein Chair in Cell Therapy and Transplantation

www.armandkeating.com [email protected]

Keeley, Fred Hospital for Sick Children U. Toronto ON Biomaterials Cardiovascular Heart and Stroke Foundation of Ontario—Robert M. Freedom Chair in Cardiovascular Science

www.sickkids.ca/AboutSickKids/Directory/People/K/Frederick-Keeley-staff-profi le.html

[email protected]


U. Toronto ON Stem cells—embryonic Various, incl. hematological, cardiovascular

CRC in Embryonic Stem Cell Biology

www.uhn.ca/donate/tgwh/site/mcewen/bio_keller.asp

[email protected]


McMaster U. ON Stem cells—embryonic Various, incl. cutaneous, cancer

No sccri.mcmaster.ca/kelly_kevin.html [email protected]


ON Stem cells—vascular Various No www.uwo.ca/pathol/faculty/khan.html [email protected]



Metabolic—diabetes No www.cellphys.ubc.ca/faculty_pages/kieffer.html [email protected]


U. British Columbia

BC Stem cells—neural Neurological No www.brain.ubc.ca/people.htm#K [email protected]

Kislinger, Thomas Ontario Cancer Institute, UHN U. Toronto ON Stem cells—unspecifi ed

Cardiovascular No www.uhnres.utoronto.ca/researchers/profi le.php?lookup=12469

[email protected]

72





Klonisch, Thomas CancerCare Manitoba U. Manitoba MB Stem cells—cancer Cancer No www.umanitoba.ca/faculties/medicine/units/anatomy/klonischt.html

[email protected]

Knoppers, Bartha McGill U. QC Social science & humanities

SSH: Ethics, law, policy No academic.mcgill.ca/newfac/profi les/2009/by-name/knoppers.htm

[email protected]

Ko, Frank U. British Columbia

BC Tissue engineering—scaffolds

Various CRC in in Advanced Fibrous Materials

afml.ampel.ubc.ca/ProfKo.php [email protected]

Korbutt, Gregory Alberta Diabetes Institute U. Alberta AB Tissue engineering—stem cells, islet; Transplantation

Metabolic—diabetes; Other

No www.adi.med.ualberta.ca/Home/Research/PrincipalInvestigators/Bio/korbutt.cfm

[email protected]

Kothary, Rashmi K. Ottawa Hospital Research Institute U. Ottawa ON Stem cells—embryonic Various, incl. neurological, cardiovascular

University Health Research Chair in Neuromuscular Disorders

www.ohri.ca/profi les/kothary.asp [email protected]

Kreplak, Laurent Dalhousie U. NS Biomaterials—scaffolds

Various No fi zz.phys.dal.ca/~kreplak/?page_id=14 [email protected]

Krieger, Charles Simon Fraser U. BC Stem cells—bone marrow

Neurological No www2.fas.sfu.ca/kin/Faculty/Krieger.html [email protected]

Krylov, Sergey N. York U. ON Stem cells—unspecifi ed

Various CRC in Bioanalytical Chemistry

www.chem.yorku.ca/profs/krylov/ [email protected]

Krystal, Gerald Terry Fox Laboratory, BC Cancer Agency

U. British Columbia


Cancer No www.bccrc.ca/dept/terry-fox-laboratory/faculty/Krystal

[email protected]

Kuruvilla, John Ontario Cancer Institute, University Health Network



No N/A [email protected]

Kwon, Brian U. British Columbia

BC Stem cells—unspecifi ed


No www.orthosurgery.ubc.ca/faculty_bios/kwon.html [email protected]

Labbé, Jean-Claude U. Montréal QC Stem cells—unspecifi ed

Cancer CRC in Cellular Division and Differentiation

www.iric.ca/Recherche/Chercheurs/Labbe_JC.html [email protected]

Lacroix, Dan LOEX U. Laval QC Tissue engineering Various No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/dan-lacroix/index.html

[email protected]

Lagace, Diane U. Ottawa ON Stem cells—unspecifi ed

Neurological No www.med.uottawa.ca/NSC/eng/lagace.htm [email protected]

Lajoie, Gilles U. Western Ontario

ON Stem cells—embryonic Various; Proteomics No www.biochem.uwo.ca/fac/lajoie/ [email protected]

Langelier, Eve U. Sherbrooke QC Tissue engineering; Biomaterials

Musculoskeletal No www.usherbrooke.ca/gmecanique/departement/personnel/professeurs/eve-langelier/

[email protected]

Lansdorp, Peter Terry Fox Laboratory, BC Cancer Agency

U. British Columbia

BC Stem cells—various—hematopoietic, induced pluripotent, embryonic

Cancer, other No www.bccrc.ca/dept/terry-fox-laboratory/faculty/Lansdorp

[email protected]

Laposa, Rebecca U. Toronto ON Stem cells—neural Neurological No www.pharmtox.utoronto.ca/faculty/directory/laposa.htm

[email protected]

Larouche, Danielle LOEX U. Laval QC Stem cells—unspecifi ed

Various No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/danielle-larouche/index.html

[email protected]

Leavitt, Blair Centre for Molecular Medicine & Therapeutics

U. British Columbia


Neurological No www.cmmt.ubc.ca/research/investigators/leavitt/lab [email protected]

3a. Cont’d

73





Klonisch, Thomas CancerCare Manitoba U. Manitoba MB Stem cells—cancer Cancer No www.umanitoba.ca/faculties/medicine/units/anatomy/klonischt.html

[email protected]


SSH: Ethics, law, policy No academic.mcgill.ca/newfac/profi les/2009/by-name/knoppers.htm

[email protected]



Various CRC in in Advanced Fibrous Materials

afml.ampel.ubc.ca/ProfKo.php [email protected]

Korbutt, Gregory Alberta Diabetes Institute U. Alberta AB Tissue engineering—stem cells, islet; Transplantation

Metabolic—diabetes; Other

No www.adi.med.ualberta.ca/Home/Research/PrincipalInvestigators/Bio/korbutt.cfm

[email protected]

Kothary, Rashmi K. Ottawa Hospital Research Institute U. Ottawa ON Stem cells—embryonic Various, incl. neurological, cardiovascular

University Health Research Chair in Neuromuscular Disorders

www.ohri.ca/profi les/kothary.asp [email protected]


Various No fi zz.phys.dal.ca/~kreplak/?page_id=14 [email protected]


Neurological No www2.fas.sfu.ca/kin/Faculty/Krieger.html [email protected]


Various CRC in Bioanalytical Chemistry

www.chem.yorku.ca/profs/krylov/ [email protected]


U. British Columbia


Cancer No www.bccrc.ca/dept/terry-fox-laboratory/faculty/Krystal

[email protected]




No N/A [email protected]




No www.orthosurgery.ubc.ca/faculty_bios/kwon.html [email protected]


Cancer CRC in Cellular Division and Differentiation

www.iric.ca/Recherche/Chercheurs/Labbe_JC.html [email protected]

Lacroix, Dan LOEX U. Laval QC Tissue engineering Various No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/dan-lacroix/index.html

[email protected]


Neurological No www.med.uottawa.ca/NSC/eng/lagace.htm [email protected]


ON Stem cells—embryonic Various; Proteomics No www.biochem.uwo.ca/fac/lajoie/ [email protected]


Musculoskeletal No www.usherbrooke.ca/gmecanique/departement/personnel/professeurs/eve-langelier/

[email protected]


U. British Columbia


Cancer, other No www.bccrc.ca/dept/terry-fox-laboratory/faculty/Lansdorp

[email protected]

Laposa, Rebecca U. Toronto ON Stem cells—neural Neurological No www.pharmtox.utoronto.ca/faculty/directory/laposa.htm

[email protected]


Various No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/danielle-larouche/index.html

[email protected]


U. British Columbia


Neurological No www.cmmt.ubc.ca/research/investigators/leavitt/lab [email protected]

74





Lecanu, Laurent The Research Institute of the McGill University Health Centre

McGill U. QC Stem cells—neural Neurological No muhc.ca/research/researcher/laurent-lecanu-msc-phd

N/A

Lee, Patrick WK Dalhousie U. NS Stem cells—cancer Cancer No microbiology.medicine.dal.ca/people/plee/ [email protected]

Lefebvre, Louis U. British Columbia

BC Stem cells—embryonic Genetic CRC in Genomic Imprinting

www.medgen.ubc.ca/research/research_faculty/llefebvre.htm

[email protected]

Legge, Raymond U. Waterloo ON Tissue engineering—scaffolds

Various No chemeng.uwaterloo.ca/faculty/legge.html [email protected]

Leibing, Annette U. Montréal QC Social science & humanities

SSH: Social No www.meos.qc.ca [email protected]

Lemmens, Trudo U. Toronto ON Social science & humanities

SSH: Law No www.law.utoronto.ca/faculty_content.asp?profi le=33&cType=facMembers&itemPath=1/3/4/0/0

[email protected]

Leroux, Therese U. Montréal QC Social science & humanities

SSH: Policy No www.crdp.umontreal.ca/en/chercheurs/leroux_therese/index.html

[email protected]

Lessard, Julie Institute for Research in Immunology and Cancer



CRC in Molecular Genetics of Stem Cell Hematopoiesis

www.iric.ca/Recherche/Chercheurs/Lessard_FR.htm [email protected]

Levesque, Eric Centre hospitalier de l’Université Laval U. Laval QC Stem cells—hematopoietic

Cancer No www.pharmacogenomics.pha.ulaval.ca/sgc/lang/en_CA/pid/10271

[email protected]

Levin, Leonard Centre de recherche de l’Hôpital Maisonneuve-Rosemont

U. Montréal QC Stem cells—neural Eye CRC in Ophtalmology and Vision Sciences

recherche.maisonneuve-rosemont.org/en-ca/research/our-research-investigators/levin-leonard.html

[email protected]

Levy, Gary Toronto General Research Institute, University Health Network

U. Toronto ON Stem cells—various—unspecifi ed

Various, incl. immunological


[email protected]

Lewis, James Franklin Lawson Health Research Institute, London Health Sciences Centre

U. Western Ontario

ON Stem cells—bone marrow

Immunological—infl ammation

No dom.lhsc.on.ca/dom/divisions/respirology/jl.htm jfl [email protected]

Li, Julang U. Guelph ON Stem cells—dermal Reproduction—female; Other

No www.aps.uoguelph.ca/?action=faculty&id=104 [email protected]

Li, Ren-Ke McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network


Cardiovascular, cardiology

CRC in Cardiac Regeneration

www.mcewencentre.com/bio_li.asp [email protected]

Lilicrap, David Queen’s U. ON Stem cells—unspecifi ed

Hematological—hemophilia

No www.path.queensu.ca/labs/lillicrap/ [email protected]

Ly, Hung Montreal Heart Institute U. Montréal QC Stem cells—mesenchymal

Cardiology No www.icm-mhi.org/en/medecine-prof.html [email protected]

Lynn, Francis U. British Columbia

BC Stem cells—embryonic Metabolic—diabetes No www.surgery.ubc.ca/faculty/fclynn.html [email protected]

Mak, Tak Ontario Cancer Institute, University Health Network

U. Toronto ON Stem cells—mesenchymal

Cancer No www.uhnresearch.ca/researchers/profi le.php?lookup=3816

[email protected]

Marra, Marco BC Cancer Agency, Genome Sciences Centre

U. British Columbia

BC Stem cells—embryonic Various No www.bcgsc.ca/faculty/mmarra/research/view [email protected]

Marshall, Aaron U. Manitoba MB Stem cells—various—unspecifi ed

Various CRC in Molecular Immunology

umanitoba.ca/faculties/medicine/units/immunology/marshallbio.html

[email protected]

Massie, Bernard Associated with National Research Council—Biotechnology Research Institute

U. Montréal QC Stem cells—various—adult

Various, incl. hematological—hemophilia

No www.universadecouvrir.gc.ca/page/index.php?p=195&l=e

[email protected]

3a. Cont’d

75






McGill U. QC Stem cells—neural Neurological No muhc.ca/research/researcher/laurent-lecanu-msc-phd

N/A

Lee, Patrick WK Dalhousie U. NS Stem cells—cancer Cancer No microbiology.medicine.dal.ca/people/plee/ [email protected]


BC Stem cells—embryonic Genetic CRC in Genomic Imprinting

www.medgen.ubc.ca/research/research_faculty/llefebvre.htm

[email protected]


Various No chemeng.uwaterloo.ca/faculty/legge.html [email protected]


SSH: Social No www.meos.qc.ca [email protected]


SSH: Law No www.law.utoronto.ca/faculty_content.asp?profi le=33&cType=facMembers&itemPath=1/3/4/0/0

[email protected]


SSH: Policy No www.crdp.umontreal.ca/en/chercheurs/leroux_therese/index.html

[email protected]




CRC in Molecular Genetics of Stem Cell Hematopoiesis

www.iric.ca/Recherche/Chercheurs/Lessard_FR.htm [email protected]

Levesque, Eric Centre hospitalier de l’Université Laval U. Laval QC Stem cells—hematopoietic

Cancer No www.pharmacogenomics.pha.ulaval.ca/sgc/lang/en_CA/pid/10271

[email protected]


U. Montréal QC Stem cells—neural Eye CRC in Ophtalmology and Vision Sciences

recherche.maisonneuve-rosemont.org/en-ca/research/our-research-investigators/levin-leonard.html

[email protected]





[email protected]


U. Western Ontario


Immunological—infl ammation

No dom.lhsc.on.ca/dom/divisions/respirology/jl.htm jfl [email protected]

Li, Julang U. Guelph ON Stem cells—dermal Reproduction—female; Other

No www.aps.uoguelph.ca/?action=faculty&id=104 [email protected]



Cardiovascular, cardiology

CRC in Cardiac Regeneration

www.mcewencentre.com/bio_li.asp [email protected]


Hematological—hemophilia

No www.path.queensu.ca/labs/lillicrap/ [email protected]

Ly, Hung Montreal Heart Institute U. Montréal QC Stem cells—mesenchymal

Cardiology No www.icm-mhi.org/en/medecine-prof.html [email protected]


BC Stem cells—embryonic Metabolic—diabetes No www.surgery.ubc.ca/faculty/fclynn.html [email protected]



Cancer No www.uhnresearch.ca/researchers/profi le.php?lookup=3816

[email protected]


U. British Columbia

BC Stem cells—embryonic Various No www.bcgsc.ca/faculty/mmarra/research/view [email protected]

Marshall, Aaron U. Manitoba MB Stem cells—various—unspecifi ed

Various CRC in Molecular Immunology

umanitoba.ca/faculties/medicine/units/immunology/marshallbio.html

[email protected]



Various, incl. hematological—hemophilia

No www.universadecouvrir.gc.ca/page/index.php?p=195&l=e

[email protected]

76





Matyas, John Robert U. Calgary AB Stem cells—embryonic Musculoskeletal No www.cell.ucalgary.ca/j_matyas.html [email protected]

McBurney, Michael Ottawa Hospital Research Institute U. Ottawa ON Stem cells—embryonic Various—aging, cancer

No www.ohri.ca/profi les/mcburney.asp [email protected]

McDonald, Michael U. British Columbia


SSH: Ethics No www.ethics.ubc.ca/index.php?p=personweb2 [email protected]

McElwee, Kevin Vancouver Coastal Health Research Institute

U. British Columbia

BC Stem cells—mesenchymal

Cutaneous No www.hairlaboratory.com/hair-laboratory-team/kevin-mcelwee.html

[email protected]

McGann, Locksley Earl U. Alberta AB Technology—Stem cells— cryopreservation

Various No www.experts.ualberta.ca/expert.cfm?id=40321 [email protected]

McGuigan, Alison Institute of Biomaterials and Biomedical Engineering

U. Toronto ON Tissue engineering—cells

Various No www.ibbme.utoronto.ca/Page502.aspx [email protected]

McInnes, Roderick Jewish General Hospital, Lady Davis Institute

McGill U. QC Stem cells—various—embryonic, adult

Various, incl. eye Alva Chair in Human Genetics; CRC in Neurogenetics

www.ladydavis.ca/en/rodmcinnes [email protected]

McKerlie, Colin Samuel Lunenfeld Research Institute, Mount Sinai Hospital


Various No www.sickkids.ca/AboutSickKids/Directory/People/M/Colin-McKerlie.html

[email protected]

McNagny, Kelly Biomedical Research Centre U. British Columbia


Various—allergy, asthma, cardiovascular, hematological, neurological

No www.brc.ubc.ca/drupal5/node/39 [email protected]

Meakin, Susan John P. Robarts Research Institute U. Western Ontario


Neurological No www.robarts.ca/smeakin/ [email protected]

Megeney, Lynn Sprott Centre for Stem Cell Research, Ottawa Health Research Institute

U. Ottawa ON Stem cells—myocardial

Cardiovascular Mach Gaensslen Chair in Cardiac Research

www.ohri.ca/profi les/megeney.asp [email protected]

Mendez, Ivar Dalhousie U. NS Stem cells—fetal Neurological No neurosurgery.medicine.dal.ca/labs.htm [email protected]

Menon, Devidas U. Alberta AB Social science & humanities

SSH: Policy No www.publichealth.ualberta.ca/research/researchers_supersivors/faculty/menon.aspx

[email protected]

Mequanint, Kibret U. Western Ontario

ON Tissue engineering—scaffolds

Various No www.eng.uwo.ca/research/compendium/faculty/kmequanint.htm

[email protected]

Merrifi eld, Peter U. Western Ontario

ON Stem cells—muscle Musculoskeletal No www.uwo.ca/anatomy/department/merrifi eldp/pmerrifi eld.html

peter.merrifi [email protected]

Metz, Luanne Associated with Hotchkiss Brain Institute

U. Calgary AB Stem cells—adult—endogenous progenitor

Neurological—multiple sclerosis

No www.hbi.ucalgary.ca/members/metz [email protected] [email protected]

Michalak, Marek S. U. Alberta AB Stem cells—embryonic Cardiovascular No www.biochem.ualberta.ca/faculty_detail.php?id=13 [email protected]

Midha, Rajiv Associated with Hotchkiss Brain Institute

U. Calgary AB Stem cells—dermal Neurological No www.hbi.ucalgary.ca/members/midha [email protected]

Miller, Freda McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network

U. Toronto ON Stem cells—various—dermal, neural

Neurological, incl. spinal cord injury

CRC in Developmental Neurobiology

www.sickkids.ca/AboutSickKids/Directory/People/M/Freda-Miller.html

[email protected]

Minden, Mark David Ontario Cancer Institute, University Health Network



[email protected]

3a. Cont’d

77





Matyas, John Robert U. Calgary AB Stem cells—embryonic Musculoskeletal No www.cell.ucalgary.ca/j_matyas.html [email protected]

McBurney, Michael Ottawa Hospital Research Institute U. Ottawa ON Stem cells—embryonic Various—aging, cancer

No www.ohri.ca/profi les/mcburney.asp [email protected]



SSH: Ethics No www.ethics.ubc.ca/index.php?p=personweb2 [email protected]


U. British Columbia


Cutaneous No www.hairlaboratory.com/hair-laboratory-team/kevin-mcelwee.html

[email protected]

McGann, Locksley Earl U. Alberta AB Technology—Stem cells— cryopreservation

Various No www.experts.ualberta.ca/expert.cfm?id=40321 [email protected]



Various No www.ibbme.utoronto.ca/Page502.aspx [email protected]



Various, incl. eye Alva Chair in Human Genetics; CRC in Neurogenetics

www.ladydavis.ca/en/rodmcinnes [email protected]



Various No www.sickkids.ca/AboutSickKids/Directory/People/M/Colin-McKerlie.html

[email protected]

McNagny, Kelly Biomedical Research Centre U. British Columbia


Various—allergy, asthma, cardiovascular, hematological, neurological


Meakin, Susan John P. Robarts Research Institute U. Western Ontario


Neurological No www.robarts.ca/smeakin/ [email protected]


U. Ottawa ON Stem cells—myocardial

Cardiovascular Mach Gaensslen Chair in Cardiac Research

www.ohri.ca/profi les/megeney.asp [email protected]

Mendez, Ivar Dalhousie U. NS Stem cells—fetal Neurological No neurosurgery.medicine.dal.ca/labs.htm [email protected]


SSH: Policy No www.publichealth.ualberta.ca/research/researchers_supersivors/faculty/menon.aspx

[email protected]



Various No www.eng.uwo.ca/research/compendium/faculty/kmequanint.htm

[email protected]


ON Stem cells—muscle Musculoskeletal No www.uwo.ca/anatomy/department/merrifi eldp/pmerrifi eld.html

peter.merrifi [email protected]




No www.hbi.ucalgary.ca/members/metz [email protected] [email protected]

Michalak, Marek S. U. Alberta AB Stem cells—embryonic Cardiovascular No www.biochem.ualberta.ca/faculty_detail.php?id=13 [email protected]


U. Calgary AB Stem cells—dermal Neurological No www.hbi.ucalgary.ca/members/midha [email protected]




CRC in Developmental Neurobiology

www.sickkids.ca/AboutSickKids/Directory/People/M/Freda-Miller.html

[email protected]




[email protected]

78





Moffat, Jason The Donnelly Centre U. Toronto ON Stem cells—pluripotent— induced pluripotent

Various No tdccbr.med.utoronto.ca/members/jason_moffat.html [email protected]

Mollica, Luigina Centre de recherche de l’Hôpital Maisonneuve-Rosemont


Various No recherche.maisonneuve-rosemont.org/en-ca/research/our-research-investigators/mollica-luigina.html

[email protected]

Moroy, Tarik Institut de recherches cliniques de Montréal



CRC in Hematopoiesis and Immune Cell Differentiation

www.ircm.qc.ca/microsites/moroy/en/ [email protected]

Morris, Quaid The Donnelly Centre, Banting and Best Department of Medical Research

U. Toronto ON Stem cells—embryonic Various No thedonnellycentre.utoronto.ca/members/quaid_morris.html

[email protected]

Morshead, Cindi U. Toronto ON Stem cells—neural Neurological, other No www.utoronto.ca/morsheadlab/ [email protected]

Moulin, Véronique LOEX U. Laval QC Tissue engineering—stem cells

Various No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/veronique-moulin/index.html

[email protected]

Munoz Risueno, Ruth Stem Cell and Cancer Research Institute


Cancer—leukemia No sccri.mcmaster.ca/risueno_ruth_munoz.html [email protected]

Mwale, Fackson Jewish General Hospital, Lady Davis Institute


Musculoskeletal—disc No www.ladydavis.ca/en/facksonmwale [email protected]

Nagano, Makoto The Research Institute of the McGill University Health Centre

McGill U. QC Stem cells—germline—sperm

Reproduction—male No people.muhc.ca/makoto.nagano/ [email protected]

Nagy, Andras Samuel Lunenfeld Research Institute, Mount Sinai Hospital and McEwen Centre for Regenerative Medicine, University Health Network

U. Toronto ON Stem cells—various—pluripotent— induced pluripotent, embryonic; Somatic

Various, incl. cancer CRC in Stem Cells and Regeneration

www.lunenfeld.ca/researchers/nagy [email protected]

Nanci, Antonio U. Montréal QC Tissue engineering—cells; Biomaterials

Musculoskeletal No www.nancicalcifi edtissuegroup.com/ananci.htm [email protected]

Nazhat, Showan McGill U. QC Biomaterials—scaffolds; Tissue engineering

Musculoskeletal No www.mcgill.ca/dentistry/research/nazhat/ [email protected]

Neel, Benjamin Ontario Cancer Institute, University Health Network

U. Toronto ON Stem cells—cancer Cancer—ovarian No www.uhnresearch.ca/researchers/profi le.php?lookup=14776

[email protected]

Nemer, Mona U. Ottawa ON Stem cells—unspecifi ed

Cardiology No web5.uottawa.ca/admingov/biography_4.html N/A

Nevill, Thomas Vancouver Coastal Health Research Institute

U. British Columbia


Cancer No www.leukemiabmtprogram.org/general_information/about_us/our_doctors/nevill.html

[email protected]

O’Brien, Catherine Adell Ontario Cancer Institute, University Health Network

U. Toronto ON Stem cells—cancer Cancer—colorectal No generalsurgery.utoronto.ca/faculty/list/obrien.htm [email protected]

Ohasi, Pamela Sumiko Ontario Cancer Institute, University Health Network


Cancer CRC in Autoimmunity and Tumour Immunity


[email protected]

Opas, Michal J. U. Toronto ON Stem cells—embryonic Various—musculoskeletal, cardiovascular

No icarus.med.utoronto.ca/patho/faculty.asp?FacultyID=349

[email protected]

Paige, Christopher Ontario Cancer Institute, University Health Network

U. Toronto ON Stem cells—various—embryonic, cancer

Cancer No www.uhnres.utoronto.ca/researchers/profi le.php?lookup=4608

[email protected]

3a. Cont’d

79





Moffat, Jason The Donnelly Centre U. Toronto ON Stem cells—pluripotent— induced pluripotent

Various No tdccbr.med.utoronto.ca/members/jason_moffat.html [email protected]



Various No recherche.maisonneuve-rosemont.org/en-ca/research/our-research-investigators/mollica-luigina.html

[email protected]




CRC in Hematopoiesis and Immune Cell Differentiation

www.ircm.qc.ca/microsites/moroy/en/ [email protected]


U. Toronto ON Stem cells—embryonic Various No thedonnellycentre.utoronto.ca/members/quaid_morris.html

[email protected]

Morshead, Cindi U. Toronto ON Stem cells—neural Neurological, other No www.utoronto.ca/morsheadlab/ [email protected]


Various No www.cha.quebec.qc.ca/en/www/research/the-research-centre/researchers/veronique-moulin/index.html

[email protected]



Cancer—leukemia No sccri.mcmaster.ca/risueno_ruth_munoz.html [email protected]



Musculoskeletal—disc No www.ladydavis.ca/en/facksonmwale [email protected]



Reproduction—male No people.muhc.ca/makoto.nagano/ [email protected]



Various, incl. cancer CRC in Stem Cells and Regeneration

www.lunenfeld.ca/researchers/nagy [email protected]


Musculoskeletal No www.nancicalcifi edtissuegroup.com/ananci.htm [email protected]


Musculoskeletal No www.mcgill.ca/dentistry/research/nazhat/ [email protected]


U. Toronto ON Stem cells—cancer Cancer—ovarian No www.uhnresearch.ca/researchers/profi le.php?lookup=14776

[email protected]


Cardiology No web5.uottawa.ca/admingov/biography_4.html N/A


U. British Columbia


Cancer No www.leukemiabmtprogram.org/general_information/about_us/our_doctors/nevill.html

[email protected]


U. Toronto ON Stem cells—cancer Cancer—colorectal No generalsurgery.utoronto.ca/faculty/list/obrien.htm [email protected]



Cancer CRC in Autoimmunity and Tumour Immunity


[email protected]

Opas, Michal J. U. Toronto ON Stem cells—embryonic Various—musculoskeletal, cardiovascular


[email protected]




[email protected]

80





Pang, Stephen Queen’s U. ON Stem cells—embryonic Cardiology No anatomy.queensu.ca/faculty/pang.cfm [email protected]

Paquin, Joanne U. Québec à Montréal

QC Stem cells—various embryonic, adult

Musculoskeletal No www.biomed.uqam.ca/spip.php?rubrique60 [email protected]

Parise, Gianni McMaster U. ON Stem cells—muscle Musculoskeletal No www.science.mcmaster.ca/kinesiology/people/faculty/291-Gianni Parise.html

[email protected]

Park, Edward U. Victoria BC Technology—stem cells—cell sorting

Various No N/A [email protected]

Pasumarthi, Kishore Babu S. Dalhousie U. NS Stem cells—cardiac progenitor

Cardiology No pharmacology.medicine.dal.ca/about/people/faculty_detail.cfm?ID_People=105

[email protected]

Pelletier, Marc New Brunswick Heart Centre New Brunswick Heart Centre

NB Stem cells—mesenchymal

Cardiology No www.ctsnet.org/home/mpelletier [email protected]

Perkins, Theodore Sprott Center for Stem Cell Research, Ottawa Health Research Institute

U. Ottawa ON Stem cells—various—unspecifi ed

Various No www.perkinslab.ca/ [email protected]

Pilarski, Linda U. Alberta AB Stem cells—cancer Cancer—multiple myeloma

CRC in Biomedical Nanotechnology

www.oncology.med.ualberta.ca/faculty/facultymember.cfm?id=24

[email protected]

Pilliar, Robert U. Toronto ON Biomaterials; Tissue engineering

Musculoskeletal—bone; Dental

No www.utoronto.ca/dentistry/facultyresearch/facultyprofi les/pilliar_robert.html

[email protected]

Pilon, Nicolas U. Québec à Montréal

QC Stem cells—embryonic Neurological No www.biomed.uqam.ca/spip.php?rubrique87/ [email protected]

Piret, James Michael Smith Laboratories U. British Columbia

BC Technology—stem cells, incl. hematopoietic—high throughput analysis; Bioprocessing—cell culture

Various No www.msl.ubc.ca/faculty/piret [email protected]

Podor, Thomas iCapture U. British Columbia

BC Stem cells—hematopoietic (bone marrow)

Cardiology No www.icapture.ubc.ca/who/who_bios_tom_podor.shtml

[email protected]

Post, Martin Hospital for Sick Children U. Toronto ON Stem cells—embryonic Respiratory No www.sickkids.ca/AboutSickKids/Directory/People/P/Martin-Post.html

[email protected]

Postovit, Lynne-Marie U. Western Ontario


Cancer No www.uwo.ca/anatomy/department/postovitl/lpostovit.html

[email protected]

Pouliot, Roxane LOEX U. Laval QC Tissue engineering; Biomaterials

Musculoskeletal No www.pha.ulaval.ca/sgc/pid/4929 [email protected]

Prakash, Satya McGill U. QC Biomaterials; Tissue engineering

Cancer No www.bmed.mcgill.ca/BTCTRL/ [email protected]

Prato, Frank Lawson Health Research Institute, London Health Sciences Centre

U. Western Ontario

ON Stem cells—adult—endothelial progenitor

Cardiology No www.uwo.ca/radnuc/radiologists/prato.html [email protected]

Puri, Mira Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Embryogenesis No medbio.utoronto.ca/faculty/puri.html [email protected]

Putnins, Edward U. British Columbia

BC Stem cells—bone marrow

Musculoskeletal No www.dentistry.ubc.ca/directory/faculty/detail.asp?user_id=24&from_directory=1

[email protected]

Puymirat, Jack U. Laval QC Stem cells—amniotic Mysculoskeletal myotonic dystrophy

No jpuymiratlab.crchul.ulaval.ca/ [email protected]

Qayumi, Karim Vancouver Coastal Health Research Institute

U. British Columbia


Cardiology No www.researchers.vchri.ca/s/Researchers.asp?ReportID=40705&_Type=Researchers-Database&_Title=Qayumi-Dr.-A.-Karim

[email protected]

3a. Cont’d

81





Pang, Stephen Queen’s U. ON Stem cells—embryonic Cardiology No anatomy.queensu.ca/faculty/pang.cfm [email protected]


QC Stem cells—various embryonic, adult

Musculoskeletal No www.biomed.uqam.ca/spip.php?rubrique60 [email protected]

Parise, Gianni McMaster U. ON Stem cells—muscle Musculoskeletal No www.science.mcmaster.ca/kinesiology/people/faculty/291-Gianni Parise.html

[email protected]


Various No N/A [email protected]


Cardiology No pharmacology.medicine.dal.ca/about/people/faculty_detail.cfm?ID_People=105

[email protected]



Cardiology No www.ctsnet.org/home/mpelletier [email protected]


U. Ottawa ON Stem cells—various—unspecifi ed

Various No www.perkinslab.ca/ [email protected]

Pilarski, Linda U. Alberta AB Stem cells—cancer Cancer—multiple myeloma

CRC in Biomedical Nanotechnology

www.oncology.med.ualberta.ca/faculty/facultymember.cfm?id=24

[email protected]


Musculoskeletal—bone; Dental

No www.utoronto.ca/dentistry/facultyresearch/facultyprofi les/pilliar_robert.html

[email protected]


QC Stem cells—embryonic Neurological No www.biomed.uqam.ca/spip.php?rubrique87/ [email protected]

Piret, James Michael Smith Laboratories U. British Columbia


Various No www.msl.ubc.ca/faculty/piret [email protected]



Cardiology No www.icapture.ubc.ca/who/who_bios_tom_podor.shtml

[email protected]

Post, Martin Hospital for Sick Children U. Toronto ON Stem cells—embryonic Respiratory No www.sickkids.ca/AboutSickKids/Directory/People/P/Martin-Post.html

[email protected]



Cancer No www.uwo.ca/anatomy/department/postovitl/lpostovit.html

[email protected]


Musculoskeletal No www.pha.ulaval.ca/sgc/pid/4929 [email protected]


Cancer No www.bmed.mcgill.ca/BTCTRL/ [email protected]


U. Western Ontario


Cardiology No www.uwo.ca/radnuc/radiologists/prato.html [email protected]

Puri, Mira Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Embryogenesis No medbio.utoronto.ca/faculty/puri.html [email protected]



Musculoskeletal No www.dentistry.ubc.ca/directory/faculty/detail.asp?user_id=24&from_directory=1

[email protected]

Puymirat, Jack U. Laval QC Stem cells—amniotic Mysculoskeletal myotonic dystrophy

No jpuymiratlab.crchul.ulaval.ca/ [email protected]


U. British Columbia


Cardiology No www.researchers.vchri.ca/s/Researchers.asp?ReportID=40705&_Type=Researchers-Database&_Title=Qayumi-Dr.-A.-Karim

[email protected]

82





Quinn, Thomas McGill U. QC Tissue engineering Musculoskeletal—cartilage, ligaments

CRC in Soft Tissue Biophysics

people.mcgill.ca/thomas.quinn/ [email protected]

Radisic, Milica U. Toronto ON Tissue engineering—scaffolds, cells; Stem cells—angiogenic progenitor

Cardiology No www.labs.chem-eng.utoronto.ca/radisic/principal-investigator/

[email protected]

Rafuse, Victor Dalhousie U. NS Stem cells—pluripotent—embryonic, induced pluripotent; Neural

Neurological, including Parkinson’s, ALS

No www.anatomy.dal.ca/Rafuse/index.htm [email protected]

Rajotte, Raymond V. U. Alberta AB Stem cells—pancreatic

Metabolic—diabetes No www.adi.med.ualberta.ca/Home/Research/PrincipalInvestigators/Bio/rajotte.cfm

[email protected]

Rak, Janusz The Research Institute of the McGill University Health Centre

McGill U. QC Stem cells—cancer Cancer—brain No people.muhc.ca/janusz.rak/ [email protected]

Ramsay, Bruce Queens U. ON Tissue engineering—scaffolds

Various No chemeng.queensu.ca/people/adjunct_Instructors/bruce-ramsay/index.php

[email protected]

Rancourt, Derrick U. Calgary AB Stem cells—pluripotent—embryonic, induced pluripotent

Musculoskeletal No people.ucalgary.ca/~derlab/index.html [email protected]

Raouf, Afshin Cancer Care Manitoba—Institute of Cell Biology

U. Manitoba MB Stem cells—cancer Cancer—breast No www.umanitoba.ca/institutes/manitoba_institute_cell_biology/MICB/Rauof Afshin.htm

[email protected]

Rastegar, Mojgan U. Manitoba MB Stem cells—pluripotent—induced pluripotent, embryonic

Neurological, cancer—brain

No umanitoba.ca/faculties/medicine/units/biochem/faculty/facultylists.html

[email protected]

Reilly, Raymond Matthew U. Toronto ON Stem cells—cancer Cancer—leukemia No /www.uhnresearch.ca/researchers/profi le.php?lookup=5062

[email protected]

Reinhardt, Dieter McGill U. QC Tissue engineering—biomaterials, cells

Musculoskeletal CRC in Extracellular Matrix Biology

www.mcgill.ca/dentistry/research/reinhardt/ [email protected]

Reudelhuber, Timothy Luther Institut de recherches cliniques de Montréal

U. Montréal QC Stem cells—unspecifi ed

Cardiovascular No www.medicine.mcgill.ca/expmed/staff/reudelhuber_timothy.htm

[email protected]

Rivest, Serge Centre hospitalier de l’Université Laval U. Laval QC Stem cells—bone marrow

Neurological No www.crchuq.ulaval.ca/en/research/researchers/4681 [email protected]

Robaire, Bernard McGill U. QC Stem cells—germline Reproduction—male; Other

No www.medicine.mcgill.ca/pharma/robairelab/ [email protected]

Robert, François Institut de recherches cliniques de Montréal


Hematological No www.ircm.qc.ca/microsites/francoisrobert/en/ [email protected]

Rogers, Ian Samuel Lunenfeld Research Institute, Mount Sinai Hospital

U. Toronto ON Stem cells—various—cord blood, induced pluripotent, bone marrow

Various, including diabetes

No www.lunenfeld.ca/researchers/rogers [email protected]

Rosenberg, Lawrence The Research Institute of the McGill University Health Centre

McGill U. QC Stem cells—pancreatic

Metabolic—diabetes No www.montreal-diabetes-research-center.org/en/rosenberg/rosenberg.asp

[email protected]

Roskams, Jane U. British Columbia

BC Stem cells—neural Neurological—olfactory

No www.zoology.ubc.ca/person/roskams [email protected]

Rossant, Janet Hospital for Sick Children U. Toronto ON Stem cells—embryonic Embryogenesis Lombard Insurance Chair

www.sickkids.ca/aboutsickkids/directory/people/r/janet-rossant.html

[email protected]

3a. Cont’d

83





Quinn, Thomas McGill U. QC Tissue engineering Musculoskeletal—cartilage, ligaments

CRC in Soft Tissue Biophysics

people.mcgill.ca/thomas.quinn/ [email protected]


Cardiology No www.labs.chem-eng.utoronto.ca/radisic/principal-investigator/

[email protected]

Rafuse, Victor Dalhousie U. NS Stem cells—pluripotent—embryonic, induced pluripotent; Neural

Neurological, including Parkinson’s, ALS

No www.anatomy.dal.ca/Rafuse/index.htm [email protected]


Metabolic—diabetes No www.adi.med.ualberta.ca/Home/Research/PrincipalInvestigators/Bio/rajotte.cfm

[email protected]


McGill U. QC Stem cells—cancer Cancer—brain No people.muhc.ca/janusz.rak/ [email protected]


Various No chemeng.queensu.ca/people/adjunct_Instructors/bruce-ramsay/index.php

[email protected]


Musculoskeletal No people.ucalgary.ca/~derlab/index.html [email protected]


U. Manitoba MB Stem cells—cancer Cancer—breast No www.umanitoba.ca/institutes/manitoba_institute_cell_biology/MICB/Rauof Afshin.htm

[email protected]


Neurological, cancer—brain

No umanitoba.ca/faculties/medicine/units/biochem/faculty/facultylists.html

[email protected]

Reilly, Raymond Matthew U. Toronto ON Stem cells—cancer Cancer—leukemia No /www.uhnresearch.ca/researchers/profi le.php?lookup=5062

[email protected]


Musculoskeletal CRC in Extracellular Matrix Biology

www.mcgill.ca/dentistry/research/reinhardt/ [email protected]



Cardiovascular No www.medicine.mcgill.ca/expmed/staff/reudelhuber_timothy.htm

[email protected]

Rivest, Serge Centre hospitalier de l’Université Laval U. Laval QC Stem cells—bone marrow

Neurological No www.crchuq.ulaval.ca/en/research/researchers/4681 [email protected]

Robaire, Bernard McGill U. QC Stem cells—germline Reproduction—male; Other

No www.medicine.mcgill.ca/pharma/robairelab/ [email protected]



Hematological No www.ircm.qc.ca/microsites/francoisrobert/en/ [email protected]




No www.lunenfeld.ca/researchers/rogers [email protected]



Metabolic—diabetes No www.montreal-diabetes-research-center.org/en/rosenberg/rosenberg.asp

[email protected]


BC Stem cells—neural Neurological—olfactory

No www.zoology.ubc.ca/person/roskams [email protected]

Rossant, Janet Hospital for Sick Children U. Toronto ON Stem cells—embryonic Embryogenesis Lombard Insurance Chair

www.sickkids.ca/aboutsickkids/directory/people/r/janet-rossant.html

[email protected]

84





Rossi, Fabio Biomedical Research Centre U. British Columbia


Various CRC in Regenerative Medicine (previously)

www.brc.ubc.ca/drupal5/node/73 [email protected]

Rottapel, Robert Ontario Cancer Institute, University Health Network


Various No www.uhnres.utoronto.ca/researchers/profi le.php?lookup=5182

[email protected]

Roy, Denis-Claude Centre de recherche de l’Hôpital Maisonneuve-Rosemont

U. Montréal QC Stem cells—cancer Cancer—leukemia No recherche.maisonneuve-rosemont.org/en-ca/research/our-research-investigators/roy-denis-claude.html

[email protected]

Roy, Jean Centre de recherche de l’Hôpital Maisonneuve-Rosemont


Cancer—leukemia Chair Industrielle—Alliance/Université de Montréal Foundation on Leukemia Research

www.sct-hmr.org/en/jroy.php [email protected]

Rudnicki, Michael Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute

U. Ottawa ON Stem cells—various—embryonic, muscle, other adult

Various, incl. neuromuscular

CRC in Molecular Genetics

www.ohri.ca/profi les/rudnicki.asp [email protected]

Ruel, Marc University of Ottawa Heart Institute U. Ottawa ON Stem cells—various—mesenchymal and endothelial progenitor; Tissue engineering

Cardiology Cardiac Surgery Research Chair

www.ottawaheart.ca/misc/marc-ruel.htm [email protected]

Sabourin, Luc Ottawa Hospital Research Institute U. Ottawa ON Stem cells—various—embryonic, adult

Various No www.ohri.ca/profi les/sabourin_summ.asp [email protected]

Santamaria, Pere U. Calgary AB Stem cells—embryonic Various, incl. immunological, metabolic—diabetes

No medicine.ucalgary.ca/research/chairs/santamaria/cv [email protected]

Santerre, Paul U. Toronto ON Tissue engineering—biomaterials, cells

Cardiovascular No www.utoronto.ca/dentistry/facultyresearch/facultyprofi les/santerre.html

[email protected] [email protected]

Sauvageau, Guy Institute for Research in Immunology and Cancer

U. Montréal QC Stem cells—various—hematopoietic, embryonic

Cancer—hematological; Other

CRC in the Molecular Genetics of Normal and Cancer Cells

www.iric.ca/Recherche/Chercheurs/Sauvageau_G.html

[email protected]

Savard, Pierre U. Laval QC Stem cells—muscle Various No www.crchuq.ulaval.ca/recherche/chercheurs/4641 [email protected]

Schimmer, Aaron Ontario Cancer Institute, University Health Network

U. Toronto ON Stem cells—cancer Cancer—leukemia No www.uhnresearch.ca/researchers/profi le.php?lookup=5351

[email protected]

Schrader, John W. Biomedical Research Centre U. British Columbia


Immunological—immunodefi ciency


Schuh, Andre Ontario Cancer Institute, University Health Network

U. Toronto ON Stem cells—embryonic Hematological—hemophilia

No medbio.utoronto.ca/faculty/schuh.html [email protected]

Schultz, Kirk Child & Family Research Institute U. British Columbia


Cancer—leukemia No www.cfri.ca/our_research/researchers/search_researchers/researcher_detail.asp?ID=119

[email protected]

Schuurmans, Carol Associated with Hotchkiss Brain Institute


Neurological—stroke, spinal cord injury, eye

No www.ucalgary.ca/bmb/schuurmans [email protected]

3a. Cont’d

85





Rossi, Fabio Biomedical Research Centre U. British Columbia


Various CRC in Regenerative Medicine (previously)

www.brc.ubc.ca/drupal5/node/73 [email protected]



Various No www.uhnres.utoronto.ca/researchers/profi le.php?lookup=5182

[email protected]


U. Montréal QC Stem cells—cancer Cancer—leukemia No recherche.maisonneuve-rosemont.org/en-ca/research/our-research-investigators/roy-denis-claude.html

[email protected]



Cancer—leukemia Chair Industrielle—Alliance/Université de Montréal Foundation on Leukemia Research

www.sct-hmr.org/en/jroy.php [email protected]



Various, incl. neuromuscular

CRC in Molecular Genetics

www.ohri.ca/profi les/rudnicki.asp [email protected]

Ruel, Marc University of Ottawa Heart Institute U. Ottawa ON Stem cells—various—mesenchymal and endothelial progenitor; Tissue engineering

Cardiology Cardiac Surgery Research Chair

www.ottawaheart.ca/misc/marc-ruel.htm [email protected]

Sabourin, Luc Ottawa Hospital Research Institute U. Ottawa ON Stem cells—various—embryonic, adult

Various No www.ohri.ca/profi les/sabourin_summ.asp [email protected]

Santamaria, Pere U. Calgary AB Stem cells—embryonic Various, incl. immunological, metabolic—diabetes

No medicine.ucalgary.ca/research/chairs/santamaria/cv [email protected]


Cardiovascular No www.utoronto.ca/dentistry/facultyresearch/facultyprofi les/santerre.html

[email protected] [email protected]



Cancer—hematological; Other

CRC in the Molecular Genetics of Normal and Cancer Cells

www.iric.ca/Recherche/Chercheurs/Sauvageau_G.html

[email protected]

Savard, Pierre U. Laval QC Stem cells—muscle Various No www.crchuq.ulaval.ca/recherche/chercheurs/4641 [email protected]


U. Toronto ON Stem cells—cancer Cancer—leukemia No www.uhnresearch.ca/researchers/profi le.php?lookup=5351

[email protected]

Schrader, John W. Biomedical Research Centre U. British Columbia


Immunological—immunodefi ciency



U. Toronto ON Stem cells—embryonic Hematological—hemophilia

No medbio.utoronto.ca/faculty/schuh.html [email protected]

Schultz, Kirk Child & Family Research Institute U. British Columbia


Cancer—leukemia No www.cfri.ca/our_research/researchers/search_researchers/researcher_detail.asp?ID=119

[email protected]



Neurological—stroke, spinal cord injury, eye

No www.ucalgary.ca/bmb/schuurmans [email protected]

86





Sefton, Michael The Donnelly Centre U. Toronto ON Tissue engineering—biomaterials, cells

Various Michael E. Charles Chair in Chemical Engineering

alumni.utoronto.ca/s/731/index.aspx?sid=731&gid=36&pgid=2135; tdccbr.med.utoronto.ca/members/michael_sefton.html

[email protected]

Seguin, Cheryle U. Western Ontario

ON Stem cells—various—pluripotent, neural

Various, incl. metabolic, musculoskeletal, embryogenesis

No www.uwo.ca/physpharm/faculty/seguin_cheryle.html cheryle.seguin@ schulich.uwo.ca

Sen, Arindom U. Calgary AB Bioprocessing—stem cells—adult

Various No www.schulich.ucalgary.ca/chemical/ArindomSen [email protected]

Shaw, Patricia Ann Ontario Cancer Institute, University Health Network



[email protected]

Sheardown, Heather McMaster U. ON Biomaterials Various—eye, cardiovascular

No chemeng.mcmaster.ca/sheardown.html [email protected]

Shoichet, Molly McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network

U. Toronto ON Tissue engineering: Biomaterials—scaffolds; Stem cells

Various—neurological: Spinal cord injury, eye; Cancer

CRC in Tissue Engineering

www.mcewencentre.com/bio_shoichet.asp [email protected]@chem-eng.utoronto.ca

Simmons, Craig U. Toronto ON Technology—high throughput screening; Stem cells—mesenchymal, cord blood; Tissue engineering

Various—cardiology; Musculoskeletal—bone

CRC in Mechanobiology

www.mie.utoronto.ca/staff/profi les/simmons/ [email protected]

Singh, Sheila Stem Cell and Cancer Research Institute

McMaster U. ON Stem cells—cancer Cancer—brain CRC in Human Cancer Stem Cell Biology

sccri.mcmaster.ca/singh_sheila.html [email protected]

Skerjanc, Ilona Sylvia U. Ottawa ON Stem cells—embryonic Various—cardiovascular, musculoskeletal

No www.med.uottawa.ca/bmi/eng/skerjanc.html [email protected]

Slack, Ruth Ottawa Hospital Research Institute U. Ottawa ON Stem cells—unspecifi ed

Neurological No www.med.uottawa.ca/ruthslack/ [email protected]

Smith, Clayton Terry Fox Laboratoy, BC Cancer Agency

U. British Columbia



CRC in Cell Therapies

www.terryfoxlab.ca/people/csmith/clayton.aspx [email protected]

Smith, Lawrence C. U. Montréal QC Stem cells—embryonic Embryogenesis No www.medvet.umontreal.ca/crra/index.php/chercheurs/lawrence-c-smith

[email protected]

Song, Kevin Vancouver Coastal Health Research Institute

U. British Columbia


Cancer—lymphoma No www.vch.ca/bmt/public/referral/attending.htmlwww.leukemiabmtprogram.org/general_information/about_us/our_doctors/song.html

[email protected]

Stanford, William U. Toronto ON Stem cells—various—pluripotent—induced pluripotent, embryonic; Mesenchymal

Various, incl. musculoskeletal—osteoporosis

CRC in Stem Cell Bioengineering and Functional Genomics

www.wlstanfordlab.com/index.php [email protected]

Stanisz, Greg Sunnybrook Research Institute U. Toronto ON Stem cells—unspecifi ed

Neurological No medbio.utoronto.ca/faculty/stanisz.html [email protected]

Stewart, Alexandre University of Ottawa Heart Institute U. Ottawa ON Stem cells—cardiac Cardiology No www.ottawaheart.ca/misc/alexandre-stewart.htm [email protected]

Stewart, Duncan Sprott Centre for Stem Cell Research, Ottawa Health Research Institute

U. Ottawa ON Stem cells—adult Cardiovascular No www.ohri.ca/profi les/stewart.asp [email protected]

Stifani, Stefano Montreal Neurological Institute McGill U. QC Stem cells—embryonic Neurological—ALS No www.mni.mcgill.ca/neuro_team/neuronal_survival/stefano_stifani/

[email protected]

3a. Cont’d

87






Various Michael E. Charles Chair in Chemical Engineering

alumni.utoronto.ca/s/731/index.aspx?sid=731&gid=36&pgid=2135; tdccbr.med.utoronto.ca/members/michael_sefton.html

[email protected]



Various, incl. metabolic, musculoskeletal, embryogenesis

No www.uwo.ca/physpharm/faculty/seguin_cheryle.html cheryle.seguin@ schulich.uwo.ca


Various No www.schulich.ucalgary.ca/chemical/ArindomSen [email protected]




[email protected]

Sheardown, Heather McMaster U. ON Biomaterials Various—eye, cardiovascular

No chemeng.mcmaster.ca/sheardown.html [email protected]


U. Toronto ON Tissue engineering: Biomaterials—scaffolds; Stem cells

Various—neurological: Spinal cord injury, eye; Cancer

CRC in Tissue Engineering

www.mcewencentre.com/bio_shoichet.asp [email protected]@chem-eng.utoronto.ca


Various—cardiology; Musculoskeletal—bone

CRC in Mechanobiology

www.mie.utoronto.ca/staff/profi les/simmons/ [email protected]


McMaster U. ON Stem cells—cancer Cancer—brain CRC in Human Cancer Stem Cell Biology

sccri.mcmaster.ca/singh_sheila.html [email protected]

Skerjanc, Ilona Sylvia U. Ottawa ON Stem cells—embryonic Various—cardiovascular, musculoskeletal

No www.med.uottawa.ca/bmi/eng/skerjanc.html [email protected]

Slack, Ruth Ottawa Hospital Research Institute U. Ottawa ON Stem cells—unspecifi ed

Neurological No www.med.uottawa.ca/ruthslack/ [email protected]


U. British Columbia



CRC in Cell Therapies

www.terryfoxlab.ca/people/csmith/clayton.aspx [email protected]

Smith, Lawrence C. U. Montréal QC Stem cells—embryonic Embryogenesis No www.medvet.umontreal.ca/crra/index.php/chercheurs/lawrence-c-smith

[email protected]


U. British Columbia


Cancer—lymphoma No www.vch.ca/bmt/public/referral/attending.htmlwww.leukemiabmtprogram.org/general_information/about_us/our_doctors/song.html

[email protected]


Various, incl. musculoskeletal—osteoporosis

CRC in Stem Cell Bioengineering and Functional Genomics

www.wlstanfordlab.com/index.php [email protected]

Stanisz, Greg Sunnybrook Research Institute U. Toronto ON Stem cells—unspecifi ed

Neurological No medbio.utoronto.ca/faculty/stanisz.html [email protected]

Stewart, Alexandre University of Ottawa Heart Institute U. Ottawa ON Stem cells—cardiac Cardiology No www.ottawaheart.ca/misc/alexandre-stewart.htm [email protected]


U. Ottawa ON Stem cells—adult Cardiovascular No www.ohri.ca/profi les/stewart.asp [email protected]

Stifani, Stefano Montreal Neurological Institute McGill U. QC Stem cells—embryonic Neurological—ALS No www.mni.mcgill.ca/neuro_team/neuronal_survival/stefano_stifani/

[email protected]

88





Sun, Yu U. Toronto ON Tissue engineering—screening

Various CRC in Micro and Nano Engineering Systems

amnl.mie.utoronto.ca%20/ [email protected]

Suuronen, Erik University of Ottawa Heart Institute U. Ottawa ON Stem cells—mesenchymal and endothelial progenitor; Biomaterials—scaffolds

Cardiology No www.ottawaheart.ca/misc/erik-suuronen.htm [email protected]

Tabori, Uri Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer—brain No www.sickkids.ca/aboutsickkids/directory/people/t/uri-tabori.html

[email protected]

Tabrizian, Maryam McGill U. QC Biomaterials; Tissue engineering—scaffolds

Cardiovascular No /www.bmed.mcgill.ca/tabrizian/people_pages/maryam.htm

[email protected]

Tanentzapf, Guy U. British Columbia


Musculoskeletal No celldevelopment.ubc.ca/research/researchers/dr-guy-tanentzapf/

[email protected]

Tang, Damu St. Joseph’s Hospital (Hamilton) McMaster U. ON Stem cells—cancer Cancer—prostate No /www.hamiltonkidneyresearch.ca/page.aspx?menu=39&app=173&cat1=433&tp=2&lk=no

[email protected]

Tanner, Scott U. Toronto ON Technology—Stem cells—cancer; High throughput technology

Cancer No www.chem.utoronto.ca/ppl/faculty_profi le.php?id=186

[email protected]

Tannock, Ian Frederick Ontario Cancer Institute, University Health Network

U. Toronto ON Stem cells—cancer Cancer No www.uhnresearch.ca/researchers/profi le.php?lookup=5941

[email protected]

Tator, Charles Toronto General Research Institute, University Health Network

U. Toronto ON Stem cells—adult Neurological—spinal cord injury


[email protected]

Tetzlaff, Wolfram U. British Columbia



No www.zoology.ubc.ca/person/~tetzlaff www.zoology.ubc.ca/person/~tetzlaff

Thebaud, Bernard U. Alberta AB Stem cells—lung Respiratory CRC in Translational Lung and Vascular Development Biology

www.physiology.ualberta.ca/home/People/Academic/thebaud.cfm

[email protected]

Tian, Ganghong (Hong) Associated with National Research Council of Canada, Institute for Biological Sciences

U. Manitoba MB Stem cells—fat Cardiology No www.nrc-cnrc.gc.ca/eng/people/tian_ganghong_6253.html

[email protected]

Till, Jim Ontario Cancer Institute, University Health Network


Cancer No myprofi le.cos.com/tillj16 [email protected]

Toyserkani, Ehsan U. Waterloo ON Biomaterials—scaffolds

Musculoskeletal No www.mme.uwaterloo.ca/people/info.php?id=70 [email protected]

Toze, Cynthia BC Cancer Agency U. British Columbia



No www.leukemiabmtprogram.org/general_information/about_us/our_doctors/toze.html

[email protected]

Tran, Simon McGill U. QC Stem cells—bone marrow

Dental CRC in Craniofacial Stem Cells and Tissue Engineering

www.mcgill.ca/dentistry/research/tran/ [email protected]

Tredget, Edward Eric U. Alberta AB Stem cells—bone marrow

Cutaneous No www.surgery.ualberta.ca/Home/Divisions/surgical_research.cfm

[email protected]

Tremblay, Jacques Centre hospitalier de l’Université Laval U. Laval QC Stem cells—bone marrow

Musculoskeletal—muscular dystrophy

No www.vrr.ulaval.ca/bd/chercheur/fi che/228703.html [email protected]

3a. Cont’d

89






Various CRC in Micro and Nano Engineering Systems

amnl.mie.utoronto.ca%20/ [email protected]

Suuronen, Erik University of Ottawa Heart Institute U. Ottawa ON Stem cells—mesenchymal and endothelial progenitor; Biomaterials—scaffolds

Cardiology No www.ottawaheart.ca/misc/erik-suuronen.htm [email protected]

Tabori, Uri Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer—brain No www.sickkids.ca/aboutsickkids/directory/people/t/uri-tabori.html

[email protected]


Cardiovascular No /www.bmed.mcgill.ca/tabrizian/people_pages/maryam.htm

[email protected]



Musculoskeletal No celldevelopment.ubc.ca/research/researchers/dr-guy-tanentzapf/

[email protected]

Tang, Damu St. Joseph’s Hospital (Hamilton) McMaster U. ON Stem cells—cancer Cancer—prostate No /www.hamiltonkidneyresearch.ca/page.aspx?menu=39&app=173&cat1=433&tp=2&lk=no

[email protected]

Tanner, Scott U. Toronto ON Technology—Stem cells—cancer; High throughput technology

Cancer No www.chem.utoronto.ca/ppl/faculty_profi le.php?id=186

[email protected]


U. Toronto ON Stem cells—cancer Cancer No www.uhnresearch.ca/researchers/profi le.php?lookup=5941

[email protected]


U. Toronto ON Stem cells—adult Neurological—spinal cord injury


[email protected]




No www.zoology.ubc.ca/person/~tetzlaff www.zoology.ubc.ca/person/~tetzlaff

Thebaud, Bernard U. Alberta AB Stem cells—lung Respiratory CRC in Translational Lung and Vascular Development Biology

www.physiology.ualberta.ca/home/People/Academic/thebaud.cfm

[email protected]


U. Manitoba MB Stem cells—fat Cardiology No www.nrc-cnrc.gc.ca/eng/people/tian_ganghong_6253.html

[email protected]



Cancer No myprofi le.cos.com/tillj16 [email protected]


Musculoskeletal No www.mme.uwaterloo.ca/people/info.php?id=70 [email protected]




No www.leukemiabmtprogram.org/general_information/about_us/our_doctors/toze.html

[email protected]


Dental CRC in Craniofacial Stem Cells and Tissue Engineering

www.mcgill.ca/dentistry/research/tran/ [email protected]


Cutaneous No www.surgery.ualberta.ca/Home/Divisions/surgical_research.cfm

[email protected]

Tremblay, Jacques Centre hospitalier de l’Université Laval U. Laval QC Stem cells—bone marrow

Musculoskeletal—muscular dystrophy


90





Tremblay, Michel L. McGill U. QC Stem cells—hematopoietic

Cardiology No www.mcgill.ca/biochemistry/department/faculty/tremblay/

[email protected]

Trigatti, Bernardo Louis McMaster U. ON Stem cells—bone marrow

Cardiovascular No www.science.mcmaster.ca/biochem/faculty/trigatti/ [email protected]

Tropepe, Vince U. Toronto ON Stem cells—neural Neurological development

No www.utoronto.ca/tropepe-lab/people.html [email protected]

Tsai, Eve Sprott Centre for Stem Cell Research, Ottawa Health Research Institute

U. Ottawa ON Stem cells—unspecifi ed


No www.ohri.ca/profi les/tsai.asp [email protected]

Tsilfi dis, Catherine Sprott Centre for Stem Cell Research, Ottawa Health Research Institute

U. Ottawa ON Stem cells—adult Eye Don and Joy Maclaren Chair for Vision Research (previously)

www.ohri.ca/profi les/tsilfi dis.asp ctsilfi [email protected]

Tufenkji, Nathalie McGill U. QC Biomaterials—scaffolds

Musculoskeletal CRC in Biocolloids and Surfaces

people.mcgill.ca/nathalie.tufenkji/ [email protected]

Turksen, Kursad Sprott Centre for Stem Cell Research, Ottawa Health Research Institute

U. Ottawa ON Stem cells—various—embryonic, epidermal

Cutaneous No www.ohri.ca/profi les/turksen.asp [email protected]

Turner, Robin Michael Smith Laboratories U. British Columbia

BC Technology—Stem cells—embryonic; Analysis, production

Various No www.msl.ubc.ca/faculty/turner [email protected]

Tyndale, Rachel U. Toronto ON Stem cells—pluripotent—embryonic, induced pluripotent

Various CRC in Pharma-cogenetics

www.pharmtox.utoronto.ca/faculty/directory/tyndale.htm

[email protected]

Underhill, Michael U. British Columbia

BC Stem cells—cord blood

Musculoskeletal No www.cellphys.ubc.ca/faculty_pages/underhill.html [email protected]

Unsworth, Larry U. Alberta AB Biomaterials—scaffolds

Various No www.cme.engineering.ualberta.ca/en/FacultyStaff/FacultyAcademicStaff/Unsworth.aspx

[email protected]

van der Kooy, Derek McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network

U. Toronto ON Stem cells—neural (incl. retinal)

Neurological—brain; Eye

No medbio.utoronto.ca/faculty/vanderkooy.html [email protected]

Vanderluit, Jacqueline Memorial U. NL Stem cells—neural Neurological No www.med.mun.ca/Medicine/Faculty/Vanderluit,-Jackie.aspx

[email protected]

Verchere, Bruce U. British Columbia

BC Stem cells—adult Metabolic—diabetes No www.pathology.ubc.ca/NewPathology/Professor/Bruce_Verchere.html

[email protected]

Veres, Teodor U. Laval QC Biomaterials; Tissue engineering—cells

Cardiovascular No www.vrr.ulaval.ca/bd/chercheur/fi che/551399.html [email protected]

Vermette, Patrick U. Sherbrooke QC Tissue engineering—cell culture; Biomaterials—scaffolds

Metabolic—diabetes No www.usherbrooke.ca/gchimiquebiotech/personnel/professeurs/patrick-vermette/

[email protected]

Vincent, Michel U. Laval QC Stem cells—muscle progenitor

Various—cardiovascular, musculoskeletal


von Harsdorf, Rudiger McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network

U. Toronto ON Regeneration—heart Cardiology No www.uhnresearch.ca/researchers/profi le.php?lookup=10949

[email protected]

3a. Cont’d

91






Cardiology No www.mcgill.ca/biochemistry/department/faculty/tremblay/

[email protected]


Cardiovascular No www.science.mcmaster.ca/biochem/faculty/trigatti/ [email protected]


No www.utoronto.ca/tropepe-lab/people.html [email protected]




No www.ohri.ca/profi les/tsai.asp [email protected]


U. Ottawa ON Stem cells—adult Eye Don and Joy Maclaren Chair for Vision Research (previously)

www.ohri.ca/profi les/tsilfi dis.asp ctsilfi [email protected]


Musculoskeletal CRC in Biocolloids and Surfaces

people.mcgill.ca/nathalie.tufenkji/ [email protected]



Cutaneous No www.ohri.ca/profi les/turksen.asp [email protected]

Turner, Robin Michael Smith Laboratories U. British Columbia

BC Technology—Stem cells—embryonic; Analysis, production

Various No www.msl.ubc.ca/faculty/turner [email protected]


Various CRC in Pharma-cogenetics

www.pharmtox.utoronto.ca/faculty/directory/tyndale.htm

[email protected]



Musculoskeletal No www.cellphys.ubc.ca/faculty_pages/underhill.html [email protected]


Various No www.cme.engineering.ualberta.ca/en/FacultyStaff/FacultyAcademicStaff/Unsworth.aspx

[email protected]




No medbio.utoronto.ca/faculty/vanderkooy.html [email protected]

Vanderluit, Jacqueline Memorial U. NL Stem cells—neural Neurological No www.med.mun.ca/Medicine/Faculty/Vanderluit,-Jackie.aspx

[email protected]


BC Stem cells—adult Metabolic—diabetes No www.pathology.ubc.ca/NewPathology/Professor/Bruce_Verchere.html

[email protected]


Cardiovascular No www.vrr.ulaval.ca/bd/chercheur/fi che/551399.html [email protected]


Metabolic—diabetes No www.usherbrooke.ca/gchimiquebiotech/personnel/professeurs/patrick-vermette/

[email protected]


Various—cardiovascular, musculoskeletal



U. Toronto ON Regeneration—heart Cardiology No www.uhnresearch.ca/researchers/profi le.php?lookup=10949

[email protected]

92





von Tigerstrom, Barbara U. Saskatchewan Sask Social science & humanities

SSH: Law No www.usask.ca/law/about_us/bio.php?id=19 [email protected]

Waddell, Thomas McEwen Centre for Regenerative Medicine, Toronto General Research Institute, University Health Network


Respiratory—lung transplant


[email protected]

Waldman, Stephen Queens U. ON Tissue engineering—cell culture

Musculoskeletal CRC in Engineering of Human Joints

www.chemeng.queensu.ca/people/faculty/waldman/ [email protected]

Walker, Gilbert Creighton U. Toronto ON Biomaterials Cardiovascular CRC in Molecular Microscopy and Nanophotonic Devices

www.chem.utoronto.ca/~gwalker/ [email protected]

Wall, Donna Cancer Care Manitoba U. Manitoba MB Stem cells—hematological

Cancer No www.cancercare.mb.ca/resource/File/Super_Seven_Bios.pdf

[email protected]

Wallace, Valerie Sprott Centre for Stem Cell Research, Ottawa Health Research Institute

U. Ottawa ON Stem cells—retinal Eye No www.ohri.ca/profi les/wallace.asp [email protected]

Walus, Konrad U. British Columbia

BC Biomaterials—scaffolds

Various—musculoskeletal, cutaneous

No www.mina.ubc.ca/konradw [email protected]

Wang, Chen U. Toronto ON Stem cells—hematopoietic



[email protected]

Wang, Lisheng U. Ottawa ON Stem cells—embryonic Various No www.med.uottawa.ca/associations/oisb/members/member_lisheng_wang.htm

[email protected]

Ward, Christopher Andrew Queen’s U. ON Stem cells—mesenchymal

Cardiology No www.queensu.ca/cgi-bin/ph/whois.queensu.ca?Query=deptcode=D922_34

[email protected]

Warnock, Garth Vancouver Coastal Health Research Institute

U. British Columbia


Metabolic—diabetes No www.surgery.ubc.ca/faculty/gwarnock.html [email protected]

Weisel, Richard Toronto General Research Institute, University Health Network

U. Toronto ON Tissue engineering: Stem cells—transplantation

Cardiology No www.uhn.ca/media/faq/experts/research/res_exp_weisel.asp

[email protected]

Weiss, Samuel Associated with Hotchkiss Brain Institute

U. Calgary AB Stem cells—neural Neurological—brain, olfactory

No www.ucalgary.ca/gdrg/sweiss.html [email protected]

Wells, Richard Alexander Sunnybrook Research Institute U. Toronto ON Stem cells—hematopoietic

Cancer—leukemia No sunnybrook.ca/research/team/member.asp?t=13&m=177&page=187

[email protected]

Wells, Sarah Dalhousie U. NS Tissue engineering—scaffolds

Cardiovascular No bme.medicine.dal.ca/faculty/wells/ [email protected]

Wertheimer, Michel Robert École polytechnique de Montréal

QC Biomaterials Various No www.polymtl.ca/recherche/rc/en/professeurs/details.php?NoProf=150

[email protected]

Whyne, Cari Sunnybrook Research Institute U. Toronto ON Tissue engineering Musculoskeletal No sunnybrook.ca/research/team/member.asp?t=13&m=178&page=172

[email protected]

Wiper-Bergeron, Nadine Louise U. Ottawa ON Stem cells—mesenchymal

Musculoskeletal No www.med.uottawa.ca/research/wiper-bergeronlab/ [email protected]

Wong, Peggy Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer—leukemia No www.ontariodoctordirectory.ca/Toronto/Doctor-Peggy-Pui-Chi-Wong-31836.html

N/A

Woodgett, James Samuel Lunenfeld Research Institute, Mount Sinai Hospital

U. Toronto ON Stem cells—adult Various, incl. cancer, metabolic—diabetes, neurological

No www.lunenfeld.ca/researchers/woodgett [email protected]

3a. Cont’d

93






SSH: Law No www.usask.ca/law/about_us/bio.php?id=19 [email protected]



Respiratory—lung transplant


[email protected]


Musculoskeletal CRC in Engineering of Human Joints

www.chemeng.queensu.ca/people/faculty/waldman/ [email protected]

Walker, Gilbert Creighton U. Toronto ON Biomaterials Cardiovascular CRC in Molecular Microscopy and Nanophotonic Devices

www.chem.utoronto.ca/~gwalker/ [email protected]

Wall, Donna Cancer Care Manitoba U. Manitoba MB Stem cells—hematological

Cancer No www.cancercare.mb.ca/resource/File/Super_Seven_Bios.pdf

[email protected]


U. Ottawa ON Stem cells—retinal Eye No www.ohri.ca/profi les/wallace.asp [email protected]



Various—musculoskeletal, cutaneous

No www.mina.ubc.ca/konradw [email protected]




[email protected]

Wang, Lisheng U. Ottawa ON Stem cells—embryonic Various No www.med.uottawa.ca/associations/oisb/members/member_lisheng_wang.htm

[email protected]


Cardiology No www.queensu.ca/cgi-bin/ph/whois.queensu.ca?Query=deptcode=D922_34

[email protected]


U. British Columbia


Metabolic—diabetes No www.surgery.ubc.ca/faculty/gwarnock.html [email protected]



Cardiology No www.uhn.ca/media/faq/experts/research/res_exp_weisel.asp

[email protected]



No www.ucalgary.ca/gdrg/sweiss.html [email protected]

Wells, Richard Alexander Sunnybrook Research Institute U. Toronto ON Stem cells—hematopoietic

Cancer—leukemia No sunnybrook.ca/research/team/member.asp?t=13&m=177&page=187

[email protected]


Cardiovascular No bme.medicine.dal.ca/faculty/wells/ [email protected]


QC Biomaterials Various No www.polymtl.ca/recherche/rc/en/professeurs/details.php?NoProf=150

[email protected]

Whyne, Cari Sunnybrook Research Institute U. Toronto ON Tissue engineering Musculoskeletal No sunnybrook.ca/research/team/member.asp?t=13&m=178&page=172

[email protected]


Musculoskeletal No www.med.uottawa.ca/research/wiper-bergeronlab/ [email protected]

Wong, Peggy Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer—leukemia No www.ontariodoctordirectory.ca/Toronto/Doctor-Peggy-Pui-Chi-Wong-31836.html

N/A


U. Toronto ON Stem cells—adult Various, incl. cancer, metabolic—diabetes, neurological

No www.lunenfeld.ca/researchers/woodgett [email protected]

94





Woodhouse, Kimberly Queen’s U. ON Tissue engineering—scaffolds, stem cells

Cardiovascular No chemeng.queensu.ca/people/faculty/woodhouse/index.php

[email protected]

Wouters, Bradley Ontario Cancer Institute, University Health Network

U. Toronto ON Stem cells—cancer Cancer No www.uhnres.utoronto.ca/researchers/profi le.php?lookup=27665

[email protected]

Wrana, Jeffrey Samuel Lunenfeld Research Institute, Mount Sinai Hospital

U. Toronto ON Technology—stem cells—high throughput analysis

Cancer CRC in Systems Biology; Mary Janigan Research Chair in Molecular Cancer Therapeutics

www.lunenfeld.ca/researchers/Wrana [email protected]

Wynder, Christopher McMaster U. ON Stem cells—embryonic Cancer CRC in Epigenetic Control of Stem Cells

fhs.mcmaster.ca/main/canada_chairs/epigenetic_control_of_stem_cells_chair.html

[email protected]

Yahia, L’Hocine École polytechnique de Montreal

QC Biomaterials Musculoskeletal No www.polymtl.ca/recherche/rc/en/professeurs/details.php?NoProf=243

[email protected]

Yang, Xiang-Jiao McGill U. QC Stem cells—various—unspecifi ed

Aging No www.mcgill.ca/mog/research/yang/ [email protected]

Yip, Christopher The Donnelly Centre U. Toronto ON Stem cells—hematopoietic

Various No biochemistry.utoronto.ca/yip/bch.html [email protected]

Yong, Von Wee Associated with Hotchkiss Brain Institute

U. Calgary AB Stem cells—hematopoietic


No www.hbi.ucalgary.ca/members/yong [email protected]

Zackenhaus, Eldad U. Toronto ON Stem cells—cancer Cancer No medbio.utoronto.ca/faculty/zacksenhaus.html [email protected]


U. Toronto ON Stem cells—various including embryonic, hematopoietic

Various, incl. hematological

CRC in Stem Cell Bioengineering

stemcell.ibme.utoronto.ca/ [email protected]

Zhang, Ze U. Laval QC Tissue engineering—scaffolds

Various No www.crchuq.ulaval.ca/en/research/researchers/8491 www.vrr.ulaval.ca/bd/chercheur/fi che/283780.html

[email protected]

Ziltener, Hermann Johann Biomedical Research Centre U. British Columbia


Various No www.brc.ubc.ca/drupal5/node/38 [email protected]

Zúñiga-Pfl ücker, Juan-Carlos Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Immunological—immunodefi ciency

CRC in Developmental Immunology

www.sunnybrook.ca/research/team/member.asp?t=13&m=191&page=1100

[email protected]

3a. Cont’d

95






Cardiovascular No chemeng.queensu.ca/people/faculty/woodhouse/index.php

[email protected]


U. Toronto ON Stem cells—cancer Cancer No www.uhnres.utoronto.ca/researchers/profi le.php?lookup=27665

[email protected]



Cancer CRC in Systems Biology; Mary Janigan Research Chair in Molecular Cancer Therapeutics

www.lunenfeld.ca/researchers/Wrana [email protected]

Wynder, Christopher McMaster U. ON Stem cells—embryonic Cancer CRC in Epigenetic Control of Stem Cells

fhs.mcmaster.ca/main/canada_chairs/epigenetic_control_of_stem_cells_chair.html

[email protected]

Yahia, L’Hocine École polytechnique de Montreal

QC Biomaterials Musculoskeletal No www.polymtl.ca/recherche/rc/en/professeurs/details.php?NoProf=243

[email protected]

Yang, Xiang-Jiao McGill U. QC Stem cells—various—unspecifi ed

Aging No www.mcgill.ca/mog/research/yang/ [email protected]


Various No biochemistry.utoronto.ca/yip/bch.html [email protected]




No www.hbi.ucalgary.ca/members/yong [email protected]

Zackenhaus, Eldad U. Toronto ON Stem cells—cancer Cancer No medbio.utoronto.ca/faculty/zacksenhaus.html [email protected]



Various, incl. hematological

CRC in Stem Cell Bioengineering

stemcell.ibme.utoronto.ca/ [email protected]


Various No www.crchuq.ulaval.ca/en/research/researchers/8491 www.vrr.ulaval.ca/bd/chercheur/fi che/283780.html

[email protected]

Ziltener, Hermann Johann Biomedical Research Centre U. British Columbia


Various No www.brc.ubc.ca/drupal5/node/38 [email protected]

Zúñiga-Pfl ücker, Juan-Carlos Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Immunological—immunodefi ciency

CRC in Developmental Immunology

www.sunnybrook.ca/research/team/member.asp?t=13&m=191&page=1100

[email protected]

96

researCHerresearCH institution

universitY/ institution provinCe regen. Med desCription

tissue engineering inCluding BioMaterials



Antoniou, John Jewish General Hospital

McGill U. QC Tissue engineering—scaffold; Stem cells—mesenchymal


Barralet, Jake McGill U. QC Biomaterials

Barrett, Christopher McGill U. QC Biomaterials


Brash, John McMaster U. ON Biomaterials

Brunette, Donald Biomedical Research Centre

U. British Columbia


Burt, Helen Mary Biomedical Research Centre

U. British Columbia



QC Biomaterials


Catelas, Isabelle U. Ottawa ON Tissue engineering




Davies, John U. Toronto ON Tissue engineering—scaffolds; Stem cells—mesnchymal


QC Biomaterials



Farhat, Walid Hospital for Sick Children

U. Toronto ON Tissue engineering —cells, scaffold

LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCHERS33b. Researchers According to Regenerative Medicine Focus

3

97

appendiX3B. RESEARCHERS ACCORDING TO

REGENERATIVE MEDICINE FOCUS








Filiaggi, Mark J. Dalhousie U. NS Biomaterials


Giasson, Claude J. LOEX affi liation U. Montréal QC Tissue engineering







Hoare, Todd McMaster U. ON Biomaterials





Jones, Elizabeth McGill U. QC Tissue engineering

Jones, Kim McMaster U. ON Biomaterials

Kamacheva, Eugenia U. Toronto ON Biomaterials



Keeley, Fred Hospital for Sick Children

U. Toronto ON Biomaterials



Korbutt, Gregory Alberta Diabetes Institute

U. Alberta AB Tissue engineering—stem cells, islet; Transplantation

98





Lacroix, Dan LOEX U. Laval QC Tissue engineering













Quinn, Thomas McGill U. QC Tissue engineering






Sheardown, Heather McMaster U. ON Biomaterials


U. Toronto ON Tissue engineering: biomaterials—scaffolds; Stem cells








3b. Cont’d

3

99






Walker, Gilbert Creighton U. Toronto ON Biomaterials







QC Biomaterials

Whyne, Cari Sunnybrook Research Institute

U. Toronto ON Tissue engineering


Yahia, L’Hocine École polytechnique de Montréal

QC Biomaterials


Ziltener, Hermann Johann Biomedical Research Centre

U. British Columbia


BioproCessing






QC Bioprocessing




steM Cell Handling teCHnologies (e.g., HigH tHrougHput sorting, CrYopreservation)


Figeys, Daniel U. Ottawa ON Technology—stem cells—cell handling

McGann, Locksley Earl U. Alberta AB Technology—stem cells— cryopreservation


100




Piret, James Michael Smith Laboratories

U. British Columbia



Tanner, Scott U. Toronto ON Technology—stem cells—cancer; High throughput technology

Turner, Robin Michael Smith Laboratories

U. British Columbia

BC Technology—stem cells—embryonic; Analysis, production



regeneration unspeCified

Akimenko, Marie-Andrée Ottawa Hospital Research Institute

U. Ottawa ON Regeneration—unspecifi ed—tissue



U. Toronto ON Regeneration—unspecifi ed—heart

soCial sCienCes & HuManities



















3b. Cont’d

3

101






steM Cells—pluripotent

eMBrYoniC


U. Toronto ON Stem cells—embryonic


McMaster U. ON Stem cells—embryonic



Dufort, Daniel McGill U. QC Stem cells—embryonic

Dumont, Dan Sunnybrook Research Institute





U. British Columbia

BC Stem cells—embryonic


U. Montréal QC Stem cells—embryonic




U. Manitoba MB Stem cells—embryonic


U. British Columbia


Huang, Sui U. Calgary AB Stem cells—embryonic





Julius, Michael Sunnybrook Research Institute


Kaern, Mads U. Ottawa ON Stem cells—embryonic

102








Kothary, Rashmi K. Ottawa Hospital Research Institute

U. Ottawa ON Stem cells—embryonic


ON Stem cells—embryonic






U. British Columbia


Matyas, John Robert U. Calgary AB Stem cells—embryonic

McBurney, Michael Ottawa Hospital Research Institute

U. Ottawa ON Stem cells—embryonic

Michalak, Marek S. U. Alberta AB Stem cells—embryonic



Opas, Michal J. U. Toronto ON Stem cells—embryonic

Pang, Stephen Queen’s U. ON Stem cells—embryonic


QC Stem cells—embryonic

Post, Martin Hospital for Sick Children


Puri, Mira Sunnybrook Research Institute


Rossant, Janet Hospital for Sick Children


Santamaria, Pere U. Calgary AB Stem cells—embryonic



Skerjanc, Ilona Sylvia U. Ottawa ON Stem cells—embryonic

Smith, Lawrence C. U. Montréal QC Stem cells—embryonic

Stifani, Stefano Montreal Neurological Institute

McGill U. QC Stem cells—embryonic

Wang, Lisheng U. Ottawa ON Stem cells—embryonic

3b. Cont’d

3

103





Wynder, Christopher McMaster U. ON Stem cells—embryonic

Zúñiga-Pfl ücker, Juan-Carlos Sunnybrook Research Institute


induCed pluripotent


ON Stem cells—pluripotent—induced pluripotent

Moffat, Jason The Donnelly Centre U. Toronto ON Stem cells—pluripotent—induced pluripotent

induCed pluripotent and eMBrYoniC

Ellis, James Hospital for Sick Children

U. Toronto ON Stem cells—pluripotent—embryonic, induced pluripotent


Rafuse, Victor Dalhousie U. NS Stem cells—pluripotent—embryonic, induced pluripotent; neural




steM Cells—tissue speCifiC

steM Cells—adult unspeCified

Antel, Jack McGill U. QC Stem cells—adult unspecifi ed


U. Ottawa ON Stem cells—adult unspecifi ed



Carrier, Patrick LOEX U. Laval QC Stem cells—adult—epithelial (from cornea)






U. Western Ontario

ON Stem cells—adult unspecifi ed



104





U. Calgary AB Stem cells—adult unspecifi ed




U. Western Ontario





U. Toronto ON Stem cells—adult unspecifi ed




BC Stem cells—adult unspecifi ed


U. Toronto ON Stem cells—adult unspecifi ed

steM Cells—aMniotiC

Puymirat, Jack U. Laval QC Stem cells—amniotic

steM Cells—Bone MarroW

Hess, David John P. Robarts Research Institute

U. Western Ontario






U. Western Ontario





U. British Columbia


Rivest, Serge Centre hospitalier de l’Université Laval

U. Laval QC Stem cells—bone marrow

3b. Cont’d

3

105









Tremblay, Jacques Centre hospitalier de l’Université Laval

U. Laval QC Stem cells—bone marrow


steM Cells—CanCer


U. Western Ontario

ON Stem cells—cancer

Bramson, Jonathan McMaster U. ON Stem cells—cancer


U. British Columbia

BC Stem cells—cancer

Dankort, David McGill U. QC Stem cells—cancer

DeCoteau, John U. Saskatchewan Sask Stem cells—cancer

Geyer, Ronald U. Saskatchewan Sask Stem cells—cancer

Ghanekar, Anand U. Toronto ON Stem cells—cancer

Giacomantonio, Carman A. Dalhousie U. NS Stem cells—cancer


U. Toronto ON Stem cells—cancer



Hombach-Klonisch, Sabine U. Manitoba MB Stem cells—cancer

Kamnasaran, Deepak U. Laval QC Stem cells—cancer

Kaplan, David Hospital for Sick Children


Klonisch, Thomas CancerCare Manitoba U. Manitoba MB Stem cells—cancer

Lee, Patrick W.K. Dalhousie U. NS Stem cells—cancer





Pilarski, Linda U. Alberta AB Stem cells—cancer


McGill U. QC Stem cells—cancer

106





U. Manitoba MB Stem cells—cancer

Reilly, Raymond Matthew U. Toronto ON Stem cells—cancer


U. Montréal QC Stem cells—cancer




McMaster U. ON Stem cells—cancer

Tabori, Uri Hospital for Sick Children


Tang, Damu St. Joseph’s Hospital (Hamilton)

McMaster U. ON Stem cells—cancer



Wong, Peggy Hospital for Sick Children




Zackenhaus, Eldad U. Toronto ON Stem cells—cancer

steM Cells—CardiaC


U. Ottawa ON Stem cells—cardiac


Stewart, Alexandre University of Ottawa Heart Institute

U. Ottawa ON Stem cells—cardiac

steM Cells—Cord Blood






steM Cells—derMal


U. Calgary AB Stem cells—dermal

3b. Cont’d

3

107





Li, Julang U. Guelph ON Stem cells—dermal


U. Calgary AB Stem cells—dermal

steM Cells—fat


U. Manitoba MB Stem cells—fat




U. Manitoba MB Stem cells—fat

steM Cells—fetal


U. Montréal QC Stem cells—fetal

Mendez, Ivar Dalhousie U. NS Stem cells—fetal

steM Cells—gastrointestinal




steM Cells—gerMline




Robaire, Bernard McGill U. QC Stem cells—germline

steM Cells—HeMatopoietiC



Anderson, Michele Sunnybrook Research Institute




108









Beausejour, Christian Hôpital Sainte-Justine (Montréal)


Ben-David, Yaacov Sunnybrook Research Institute





Carreau, Madeleine Centre hospitalier de l’Université Laval

U. Laval QC Stem cells—hematopoietic








U. British Columbia



Gassas, Adam Hospital for Sick Children


Guidos, Cynthia Hospital for Sick Children






U. British Columbia





U. British Columbia


3b. Cont’d

3

109








U. British Columbia






U. British Columbia




Levesque, Eric Centre hospitalier de l’Université Laval

U. Laval QC Stem cells—hematopoietic



McNagny, Kelly Biomedical Research Centre

U. British Columbia











U. British Columbia






Rossi, Fabio Biomedical Research Centre

U. British Columbia




110






Schrader, John W. Biomedical Research Centre

U. British Columbia


Schultz, Kirk Child & Family Research Institute

U. British Columbia



U. British Columbia



U. British Columbia





Wall, Donna Cancer Care Manitoba U. Manitoba MB Stem cells—hematopoietic


Wells, Richard Alexander Sunnybrook Research Institute





steM Cells—lung

Thebaud, Bernard U. Alberta AB Stem cells—lung

steM Cells—MaMMarY


BC Stem cells—mammary

Egan, Sean Hospital for Sick Children

U. Toronto ON Stem cells—mammary epithelial

steM Cells—MesenCHYMal

Alman, Benjamin Hospital for Sick Children



Dick, Alexander Sunnybrook Research Institute


Eliopoulos, Nicoletta McGill U. QC Stem cells—mesenchymal





3b. Cont’d

3

111





Ly, Hung Montreal Heart Institute





U. British Columbia




Ohashi, Pamela Sumiko Ontario Cancer Institute, University Health Network


Pelletier, Marc New Brunswick Heart Centre

New Brunswick Heart Centre




Suuronen, Erik University of Ottawa Heart Institute

U. Ottawa ON Stem cells—mesenchymal and endothelial progenitor; Biomaterials—scaffolds





steM Cells—MusCle






ON Stem cells—muscle

Parise, Gianni McMaster U. ON Stem cells—muscle

Savard, Pierre U. Laval QC Stem cells—muscle


steM Cells—neural

Aviv, Tzvi Hospital for Sick Children

U. Toronto ON Stem cells—neural

Bennett, Steffany U. Ottawa ON Stem cells—neural

Calderone, Angelo Montreal Heart Institute

U. Montréal QC Stem cells—neural

112






Cregan, Sean John P. Robarts Research Institute

U. Western Ontario

ON Stem cells—neural

Dirks, Peter Hospital for Sick Children


Fehlings, Michael McEwen Centre for Regenerative Medicine and McLaughlin Center for Molecular Medicine, Toronto Western Research Institute, University Health Network


Fernandes, Karl U. Montréal QC Stem cells—neural

Hazell, Alan Stewart Centre de recherche du Centre hospitalier de l’Université de Montréal


Huang, Annie Hospital for Sick Children


Karimi-Abdolrezaee, Soheila U. Manitoba MB Stem cells—neural


U. British Columbia

BC Stem cells—neural

Laposa, Rebecca U. Toronto ON Stem cells—neural


McGill U. QC Stem cells—neural



Morshead, Cindi U. Toronto ON Stem cells—neural


BC Stem cells—neural

Tropepe, Vince U. Toronto ON Stem cells—neural



Vanderluit, Jacqueline Memorial U. NL Stem cells—neural

3b. Cont’d

3

113






U. Calgary AB Stem cells—neural

steM Cells—ovarian epitHelial


steM Cells—panCreatiC








U. British Columbia


steM Cells—retinal

Chow, Bob U. Victoria BC Stem cells—retinal


U. Ottawa ON Stem cells—retinal

steM Cells—vasCular


ON Stem cells—vascular

steM Cells—unspeCified



Cheng, Hai-Ling Margaret Sunnybrook Research Institute


Dekaban, Gregory John P. Robarts Research Institute

U. Western Ontario










114







Kislinger, Thomas Ontario Cancer Institute, UHN











U. British Columbia



Meakin, Susan John P. Robarts Research Institute

U. Western Ontario









Slack, Ruth Ottawa Hospital Research Institute


Stanisz, Greg Sunnybrook Research Institute








steM Cells—various



3b. Cont’d

3

115











U. British Columbia


Golding, Michael C. U. Western Ontario

ON Stem cells—various

Hough, Margaret Sunnybrook Research Institute

U. Toronto ON Stem cells—various—embryonic, hematopoietic

Hui, Chi-chung Hospital for Sick Children

U. Toronto ON Stem cells—various




U. British Columbia




Marshall, Aaron U. Manitoba MB Stem cells—various









116









QC Stem cells—various—embryonic, adult


U. Ottawa ON Stem cells—various





Ruel, Marc University of Ottawa Heart Institute

U. Ottawa ON Stem cells—various—mesenchymal and endothelial progenitor; Tissue engineering

Sabourin, Luc Ottawa Hospital Research Institute

U. Ottawa ON Stem cells—various—embryonic, adult








Yang, Xiang-Jiao McGill U. QC Stem cells—various



3b. Cont’d

3

117

3c. Researchers According to Disease Focus


disease desCription

aging

Yang, Xiang-Jiao McGill U. QC Aging

CanCer


U. Western Ontario ON Cancer—breast

Anderson, Michele Sunnybrook Research Institute U. Toronto ON Cancer—leukemia, lymphoma

Annabi, Borhane U. Québec à Montréal QC Cancer

Aparicio, Samuel BC Cancer Agency U. British Columbia BC Cancer—breast

Barabé, Frédéric U. Laval QC Cancer—leukemia

Beausejour, Christian Hôpital Sainte-Justine (Montréal)

U. Montréal QC Cancer

Ben-David, Yaacov Sunnybrook Research Institute U. Toronto ON Cancer—leukemia

Bijl, Janetta U. Montréal QC Cancer—leukemia

Bramson, Jonathan McMaster U. ON Cancer


U. British Columbia BC Cancer


McGill U. QC Cancer

Couban, Stephen Dalhousie U. NS Cancer—hematological


U. Toronto ON Cancer—lymphoma

Dankort, David McGill U. QC Cancer

DeCoteau, John U. Saskatchewan Sask Cancer

Dedhar, Shoukat BC Cancer Agency U. British Columbia BC Cancer


U. Toronto ON Cancer, other


U. Toronto ON Cancer, incl. leukemia

Dirks, Peter Hospital for Sick Children U. Toronto ON Cancer—brain


McMaster U. ON Cancer

Doyle, John U. Toronto ON Cancer


U. British Columbia BC Cancer—leukemia



appendiX3C. RESEARCHERS ACCORDING TO DISEASE FOCUS

118



disease desCription

Egan, Sean Hospital for Sick Children U. Toronto ON Cancer—breast

Emery, Gregory U. Montréal QC Cancer


U. Toronto ON Cancer

Gassas, Adam Hospital for Sick Children U. Toronto ON Cancer—leukemia

Geyer, Ronald U. Saskatchewan Sask Cancer

Ghanekar, Anand U. Toronto ON Cancer—liver

Giacomantonio, Carman A. Dalhousie U. NS Cancer

Grant, Denis U. Toronto ON Cancer

Guidos, Cynthia Hospital for Sick Children U. Toronto ON Cancer—leukemia

Hassell, John McMaster U. ON Cancer


U. Toronto ON Cancer—cervical


U. Manitoba MB Cancer


U. Toronto ON Cancer—cervical


U. Montréal QC Cancer—leukemia



Hombach-Klonisch, Sabine U. Manitoba MB Cancer


McMaster U. ON Cancer—leukemia

Huang, Annie Hospital for Sick Children U. Toronto ON Cancer—brain


U. Toronto ON Cancer—leukemia




U. Calgary AB Cancer


U. Montréal QC Cancer

Kamnasaran, Deepak U. Laval QC Cancer—brain

Kaplan, David Hospital for Sick Children U. Toronto ON Cancer

Karsan, Aly BC Cancer Agency U. British Columbia BC Cancer—leukemia

Keating, Armand U. Toronto ON Cancer—hematological

Klonisch, Thomas CancerCare Manitoba U. Manitoba MB Cancer

3c. Cont’d

3

119



disease desCription




U. Toronto ON Cancer—hematological

Labbé, Jean-Claude U. Montréal QC Cancer


U. British Columbia BC Cancer, other

Lee, Patrick W.K. Dalhousie U. NS Cancer


U. Montréal QC Cancer—hematological


U. Laval QC Cancer






U. Montréal QC Cancer—hematological


McMaster U. ON Cancer—leukemia


U. Toronto ON Cancer—ovarian




U. Toronto ON Cancer—colorectal





Pilarski, Linda U. Alberta AB Cancer—multiple myeloma

Postovit, Lynne-Marie U. Western Ontario ON Cancer

Prakash, Satya McGill U. QC Cancer


McGill U. QC Cancer—brain


U. Manitoba MB Cancer—breast

Reilly, Raymond Matthew U. Toronto ON Cancer—leukemia





120



disease desCription


U. Montréal QC Cancer—hematological; Other








McMaster U. ON Cancer—brain


U. British Columbia BC Cancer—hematological


U. British Columbia BC Cancer—lymphoma

Tabori, Uri Hospital for Sick Children U. Toronto ON Cancer—brain

Tang, Damu St. Joseph’s Hospital (Hamilton)

McMaster U. ON Cancer—prostate

Tanner, Scott U. Toronto ON Cancer





Toze, Cynthia BC Cancer Agency U. British Columbia BC Cancer—hematological

Wall, Donna Cancer Care Manitoba U. Manitoba MB Cancer

Wells, Richard Alexander Sunnybrook Research Institute U. Toronto ON Cancer—leukemia

Wong, Peggy Hospital for Sick Children U. Toronto ON Cancer—leukemia





Wynder, Christopher McMaster U. ON Cancer

Zackenhaus, Eldad U. Toronto ON Cancer

CardiopulMonarY


U. Ottawa ON Cardiopulmonary

CardiovasCular


U. Ottawa ON Cardiovascular

Arora, Rakesh C Associated with National Research Council of Canada, Institute for Biological Sciences

U. Manitoba MB Cardiology

3c. Cont’d

3

121



disease desCription

Calderone, Angelo Montreal Heart Institute U. Montréal QC Cardiology

Dick, Alexander Sunnybrook Research Institute U. Toronto ON Cardiology

Duff, Henry Joseph U. Calgary AB Cardiology


U. Toronto ON Cardiovascular


U. Montréal QC Cardiology


U. Toronto ON Cardiovascular

Jackson, Michael U. Manitoba MB Cardiology

Jones, Elizabeth McGill U. QC Cardiovascular

Keeley, Fred Hospital for Sick Children U. Toronto ON Cardiovascular

Kislinger, Thomas Ontario Cancer Institute, UHN U. Toronto ON Cardiovascular


U. Toronto ON Cardiovascular, cardiology

Ly, Hung Montreal Heart Institute U. Montréal QC Cardiology



Michalak, Marek S. U. Alberta AB Cardiovascular

Nemer, Mona U. Ottawa ON Cardiology

Pang, Stephen Queen’s U. ON Cardiology

Pasumarthi, Kishore Babu S. Dalhousie U. NS Cardiology


NB Cardiology

Podor, Thomas iCapture U. British Columbia BC Cardiology


U. Western Ontario ON Cardiology


U. British Columbia BC Cardiology

Radisic, Milica U. Toronto ON Cardiology


U. Montréal QC Cardiovascular

Ruel, Marc University of Ottawa Heart Institute

U. Ottawa ON Cardiology

122



disease desCription

Santerre, Paul U. Toronto ON Cardiovascular

Stewart, Alexandre University of Ottawa Heart Institute




Suuronen, Erik University of Ottawa Heart Institute


Tabrizian, Maryam McGill U. QC Cardiovascular


U. Manitoba MB Cardiology

Tremblay, Michel L. McGill U. QC Cardiology

Trigatti, Bernardo Louis McMaster U. ON Cardiovascular

Veres, Teodor U. Laval QC Cardiovascular


U. Toronto ON Cardiology

Walker, Gilbert Creighton U. Toronto ON Cardiovascular

Ward, Christopher Andrew Queen’s U. ON Cardiology


U. Toronto ON Cardiology

Wells, Sarah Dalhousie U. NS Cardiovascular

Woodhouse, Kimberly Queen’s U. ON Cardiovascular

Cutaneous


U. British Columbia BC Cutaneous

Tredget, Edward Eric U. Alberta AB Cutaneous


U. Ottawa ON Cutaneous

dental

Hamilton, Douglas U. Western Ontario ON Dental

Tran, Simon McGill U. QC Dental

Tran, Simon McGill U. QC Dental

eMBrYogenesis

Golding, Michael C. U. Western Ontario ON Embryogenesis


U. British Columbia BC Embryogenesis

3c. Cont’d

3

123



disease desCription

Puri, Mira Sunnybrook Research Institute U. Toronto ON Embryogenesis

Rossant, Janet Hospital for Sick Children U. Toronto ON Embryogenesis

Smith, Lawrence C. U. Montréal QC Embryogenesis

gastrointestinal

Bjerknes, Matthew J. U. Toronto ON Gastrointestinal

genetiC

Hough, Margaret Sunnybrook Research Institute U. Toronto ON Genetic

Lefebvre, Louis U. British Columbia BC Genetic

HeMatologiCal


U. Toronto ON Hematological—anemia, cancer


U. Ottawa ON Hematological—ß-thalassemia and sickle cell anemia

Carreau, Madeleine Centre hospitalier de l’Université Laval

U. Laval QC Hematological—anemia

Huang, Sui U. Calgary AB Hematological


U. British Columbia BC Hematological—anemia, cancer

Lilicrap, David Queen’s U. ON Hematological—hemophilia


U. Montréal QC Hematological


U. Toronto ON Hematological—hemophilia

Wang, Chen U. Toronto ON Hematological—anemia

iMMunologiCal

Denburg, Judah Aryeh McMaster U. ON Immunological—allergy, asthma

Ellis, Anne Queen’s U. ON Immunological—allergy

Helgason, Cheryl BC Cancer Agency U. British Columbia BC Immunological—autoimmune


U. Western Ontario ON Immunological—infl ammation

Schrader, John W. Biomedical Research Centre U. British Columbia BC Immunological—immunodefi ciency

Zúñiga-Pfl ücker, Juan-Carlos Sunnybrook Research Institute U. Toronto ON Immunological—immunodefi ciency

infeCtion—Hiv

Joshi, Sadhna U. Toronto ON Infection—HIV

124



disease desCription

MetaBoliC—diaBetes

Anderson, Colin C. U. Alberta AB Metabolic—diabetes


U. Western Ontario ON Metabolic—diabetes


U. Montréal QC Metabolic—diabetes

Johnson, James U. British Columbia BC Metabolic—diabetes

Kieffer, Tim U. British Columbia BC Metabolic—diabetes

Korbutt, Gregory Alberta Diabetes Institute U. Alberta AB Metabolic—diabetes; other

Lynn, Francis U. British Columbia BC Metabolic—diabetes

Rajotte, Raymond V. U. Alberta AB Metabolic—diabetes


McGill U. QC Metabolic—diabetes

Verchere, Bruce U. British Columbia BC Metabolic—diabetes

Vermette, Patrick U. Sherbrooke QC Metabolic—diabetes


U. British Columbia BC Metabolic—diabetes

MusCulosKeletal

Akimenko, Marie-Andrée Ottawa Hospital Research Institute

U. Ottawa ON Musculoskeletal

Alman, Benjamin Hospital for Sick Children U. Toronto ON Musculoskeletal

Antoniou, John Jewish General Hospital McGill U. QC Musculoskeletal

Aubin, Jane U. Toronto ON Musculoskeletal

Barralet, Jake McGill U. QC Musculoskeletal—bone formation

Brunette, Donald Biomedical Research Centre U. British Columbia BC Musculoskeletal

Burt, Helen Mary Biomedical Research Centre U. British Columbia BC Musculoskeletal


QC Musculoskeletal—cartilage cell delivery

Catelas, Isabelle U. Ottawa ON Musculoskeletal—bone loss

Davies, John U. Toronto ON Musculoskeletal—bone


U. Ottawa ON Musculoskeletal: Duchenne

Faucheux, Nathalie U. Sherbrooke QC Musculoskeletal—bone and cartilage regeneration

Ferguson, Peter Charles Mount Sinai Hospital U. Toronto ON Musculoskeletal

3c. Cont’d

3

125



disease desCription

Fernlund, Goran U. British Columbia BC Musculoskeletal

Filiaggi, Mark J. Dalhousie U. NS Musculoskeletal—bone

Fradette, Julie LOEX U. Laval QC Musculoskeletal

Frei, Hanspeter Carleton U. ON Musculoskeletal—bone

Goulet, Francine LOEX U. Laval QC Musculoskeletal

Grenier, Guillaume U. Sherbrooke QC Musculoskeletal—muscle

Harvey, Edward McGill U. QC Musculoskeletal—bone

Hawke, Thomas McMaster U. ON Musculoskeletal—muscle


QC Musculoskeletal

Hunter, Christopher U. Calgary AB Musculoskeletal—disc

Johnston, James U. Saskatchewan Sask Musculoskeletal


U. Toronto ON Musculoskeletal

Langelier, Eve U. Sherbrooke QC Musculoskeletal

Matyas, John Robert U. Calgary AB Musculoskeletal

Merrifi eld, Peter U. Western Ontario ON Musculoskeletal


McGill U. QC Musculoskeletal—disc

Nanci, Antonio U. Montréal QC Musculoskeletal

Nazhat, Showan McGill U. QC Musculoskeletal

Paquin, Joanne U. Québec à Montréal QC Musculoskeletal

Parise, Gianni McMaster U. ON Musculoskeletal

Pilliar, Robert U. Toronto ON Musculoskeletal—bone; Dental

Pouliot, Roxane LOEX U. Laval QC Musculoskeletal

Putnins, Edward U. British Columbia BC Musculoskeletal

Puymirat, Jack U. Laval QC Mysculoskeletal myotonic dystrophy

Quinn, Thomas McGill U. QC Musculoskeletal—cartilage, ligaments

Rancourt, Derrick U. Calgary AB Musculoskeletal

Reinhardt, Dieter McGill U. QC Musculoskeletal

Tanentzapf, Guy U. British Columbia BC Musculoskeletal

Toyserkani, Ehsan U. Waterloo ON Musculoskeletal

Tremblay, Jacques Centre hospitalier de l’Université Laval

U. Laval QC Musculoskeletal—muscular dystrophy

126



disease desCription

Tufenkji, Nathalie McGill U. QC Musculoskeletal

Underhill, Michael U. British Columbia BC Musculoskeletal

Waldman, Stephen Queens U. ON Musculoskeletal

Whyne, Cari Sunnybrook Research Institute U. Toronto ON Musculoskeletal

Wiper-Bergeron, Nadine Louise U. Ottawa ON Musculoskeletal

Yahia, L’Hocine École polytechnique de Montréal

QC Musculoskeletal

neurologiCal

Antel, Jack McGill U. QC Neurological—multiple sclerosis

Aviv, Tzvi Hospital for Sick Children U. Toronto ON Neurological


U. Ottawa ON Neurological—brain injury

Bennett, Steffany U. Ottawa ON Neurological, incl. Alzheimer’s


U. Calgary AB Neurological—injury, wound healing

Cao, Xudong U. Ottawa ON Neurological—spinal cord, eye

Carrier, Patrick LOEX U. Laval QC Eye


U. Montréal QC Neurological, including eye

Chen, Daniel (Xiongbiao) U. Saskatchewan Sask Neurological—peripheral

Cheng, Hai-Ling Margaret Sunnybrook Research Institute U. Toronto ON Neurological—stroke

Chow, Bob U. Victoria BC Eye

Cregan, Sean John P. Robarts Research Institute

U. Western Ontario ON Neurological


U. Western Ontario ON Neurological—spinal cord injury


U. Montréal QC Neurological—Parkinson’s


U. Calgary AB Neurological—brain


U. Toronto ON Neurological—spinal cord injury

Fernandes, Karl U. Montréal QC Neurological—neurodegenerative diseases, incl. Alzheimer’s

3c. Cont’d

3

127



disease desCription

Giasson, Claude J. LOEX affi liation U. Montréal QC Eye


U. British Columbia BC Eye


U. Ottawa ON Eye

Hazell, Alan Stewart Centre de recherche du Centre hospitalier de l’Université de Montréal

U. Montréal QC Neurological—brain injury

Hui, Chi-chung Hospital for Sick Children U. Toronto ON Neurological

Karimi-Abdolrezaee, Soheila U. Manitoba MB Neurological—spinal cord injury


U. British Columbia BC Neurological

Krieger, Charles Simon Fraser U. BC Neurological

Kwon, Brian U. British Columbia BC Neurological—spinal cord injury

Lagace, Diane U. Ottawa ON Neurological

Laposa, Rebecca U. Toronto ON Neurological


U. British Columbia BC Neurological


McGill U. QC Neurological


U. Montréal QC Eye

Meakin, Susan John P. Robarts Research Institute

U. Western Ontario ON Neurological

Mendez, Ivar Dalhousie U. NS Neurological


U. Calgary AB Neurological—multiple sclerosis


U. Calgary AB Neurological


U. Toronto ON Neurological, incl. spinal cord injury

Morshead, Cindi U. Toronto ON Neurological, other

Pilon, Nicolas U. Québec à Montréal QC Neurological

Rafuse, Victor Dalhousie U. NS Neurological, including Parkinson’s, ALS

Rastegar, Mojgan U. Manitoba MB Neurological, cancer-brain

128



disease desCription

Rivest, Serge Centre hospitalier de l’Université Laval

U. Laval QC Neurological

Roskams, Jane U. British Columbia BC Neurological—olfactory


U. Calgary AB Neurological—stroke, spinal cord injury, eye


U. Ottawa ON Neurological

Stanisz, Greg Sunnybrook Research Institute U. Toronto ON Neurological

Stifani, Stefano Montreal Neurological Institute

McGill U. QC Neurological—ALS


U. Toronto ON Neurological—spinal cord injury

Tetzlaff, Wolfram U. British Columbia BC Neurological—spinal cord injury

Tropepe, Vince U. Toronto ON Neurological development


U. Ottawa ON Neurological—spinal cord injury


U. Ottawa ON Eye


U. Toronto ON Neurological—brain; Eye

Vanderluit, Jacqueline Memorial U. NL Neurological


U. Ottawa ON Eye


U. Calgary AB Neurological—brain, olfactory


U. Calgary AB Neurological—multiple sclerosis

renal


McGill U. QC Renal

reproduCtion


U. Toronto ON Reproduction—female fertility

3c. Cont’d

3

129



disease desCription

Cross, James Charles U. Calgary AB Reproduction—female

Dobrinski, Ina U. Calgary AB Reproduction—male

Dufort, Daniel McGill U. QC Reproduction—implantation

Farookhi, Riaz McGill U. QC Reproduction—ovary

Li, Julang U. Guelph ON Reproduction—female; Other


McGill U. QC Reproduction—male

Robaire, Bernard McGill U. QC Reproduction—male; Other

respiratorY

Downey, Gregory U. Toronto ON Respiratory

Post, Martin Hospital for Sick Children U. Toronto ON Respiratory

Thebaud, Bernard U. Alberta AB Respiratory


U. Toronto ON Respiratory—lung transplant

soCial sCienCes & HuManities

Baylis, Françoise Dalhousie U. NS SSH: Ethics

Bubela, Tania U. Alberta AB SSH: Socioeconomic benefi ts

Caulfi eld, Tim U. Alberta AB SSH: Ethics and law

Chandler, Jennifer U. Ottawa ON SSH: Law, policy


U. Toronto ON SSH: Ethics and law

Einsiedel, Edna U. Calgary AB SSH: Social science

Glass, Kathleen McGill U. QC SSH: Ethics, legal

Illes, Judy U. British Columbia BC SSH: Ethics

Ingram, Liz U. Alberta AB SSH: Social

Knoppers, Bartha McGill U. QC SSH: Ethics, law, policy

Leibing, Annette U. Montréal QC SSH: Social

Lemmens, Trudo U. Toronto ON SSH: Law

Leroux, Therese U. Montréal QC SSH: Policy

McDonald, Michael U. British Columbia BC SSH: Ethic

Menon, Devidas U. Alberta AB SSH: Policy

von Tigerstrom, Barbara U. Saskatchewan Sask SSH: Law

130



disease desCription

urologiCal

El-Hakim, Assaad McGill U. QC Urological

Farhat, Walid Hospital for Sick Children U. Toronto ON Urological

various

Acker, Jason U. Alberta AB Various

Amsden, Brian Queens U. ON Various


U. Ottawa ON Various, incl. cancer—hematopoietic, neurological—MS


U. Toronto ON Various

Auger, François A. LOEX U. Laval QC Various, incl. cardiovascular, transplantation, injury



Barrett, Christopher McGill U. QC Various


U. Calgary AB Various—neurological, metabolic—diabetes

Berthod, François LOEX U. Laval QC Various, incl. neurological, urological, cutaneous

Betts, Dean U. Western Ontario ON Various


McMaster U. ON Various, incl. respiratory—lung disease

Brash, John McMaster U. ON Various


McGill U. QC Various, incl. cardiovascular

Chen, Jie U. Alberta AB Various


QC Various—musculoskeletal, cardiovascular

Doillon, Charles U. Laval QC Various—cardiovascular, cancer


McMaster U. ON Various

Dumont, Dan Sunnybrook Research Institute U. Toronto ON Various—cardiovascular, cancer

Duval, Michel U. Montréal QC Various

Elliott, Janet Anne Wade U. Alberta AB Various

Ellis, James Hospital for Sick Children U. Toronto ON Various, incl. neurological, incl. Rett’s; Hematological—anemia

3c. Cont’d

3

131



disease desCription


QC Various

Figeys, Daniel U. Ottawa ON Various

Flynn, Lauren Queen’s U. ON Various

Garnier, Alain U. Laval QC Various

Germain, Lucie LOEX U. Laval QC Various, incl. cutaneous, cardiovascular, eye

Ghanem, Amyl Dalhousie U. NS Various



Hansen, David U. Calgary AB Various


U. Montréal QC Various—renal, cardiovascular

Hess, David John P. Robarts Research Institute

U. Western Ontario ON Various—cardiovascular; Metabolic—diabetes

Heveker, Nikolaus Hôpital Sainte-Justine U. Montréal QC Various

Hoare, Todd McMaster U. ON Various



Jervis, Eric U. Waterloo ON Various


QC Various

Jones, Kim McMaster U. ON Various, incl. immunological

Julius, Michael Sunnybrook Research Institute U. Toronto ON Various, incl. immunological, cancer, infection

Kaern, Mads U. Ottawa ON Various


U. Calgary AB Various

Kamacheva, Eugenia U. Toronto ON Various


U. Toronto ON Various, incl. hematological, cardiovascular


McMaster U. ON Various, incl. cutaneous, cancer

Khan, Zia U. Western Ontario ON Various

Ko, Frank U. British Columbia BC Various

132



disease desCription

Kothary, Rashmi K. Ottawa Hospital Research Institute

U. Ottawa ON Various, incl. neurological, cardiovascular

Kreplak, Laurent Dalhousie U. NS Various

Krylov, Sergey N. York U. ON Various

Lacroix, Dan LOEX U. Laval QC Various

Lajoie, Gilles U. Western Ontario ON Various; Proteomics

Larouche, Danielle LOEX U. Laval QC Various

Legge, Raymond U. Waterloo ON Various


U. Toronto ON Various, incl. immunological


U. British Columbia BC Various

Marshall, Aaron U. Manitoba MB Various


U. Montréal QC Various, incl. hematological—hemophilia

McBurney, Michael Ottawa Hospital Research Institute

U. Ottawa ON Various—aging, cancer

McGann, Locksley Earl U. Alberta AB Various




McGill U. QC Various, incl. eye



McNagny, Kelly Biomedical Research Centre U. British Columbia BC Various—allergy, asthma, cardiovascular, hematological, neurological

Mequanint, Kibret U. Western Ontario ON Various

Moffat, Jason The Donnelly Centre U. Toronto ON Various


U. Montréal QC Various



Moulin, Véronique LOEX U. Laval QC Various

3c. Cont’d

3

133



disease desCription


U. Toronto ON Various, incl. cancer

Opas, Michal J. U. Toronto ON Various—musculoskeletal, cardiovascular

Park, Edward U. Victoria BC Various


U. Ottawa ON Various

Piret, James Michael Smith Laboratories U. British Columbia BC Various

Ramsay, Bruce Queens U. ON Various


U. Toronto ON Various, including diabetes

Rossi, Fabio Biomedical Research Centre U. British Columbia BC Various




U. Ottawa ON Various, incl. neuromuscular

Sabourin, Luc Ottawa Hospital Research Institute

U. Ottawa ON Various

Santamaria, Pere U. Calgary AB Various, incl. immunological, metabolic—diabetes

Savard, Pierre U. Laval QC Various

Sefton, Michael The Donnelly Centre U. Toronto ON Various

Seguin, Cheryle U. Western Ontario ON Various, incl. metabolic, musculoskeletal, embryogenesis

Sen, Arindom U. Calgary AB Various

Sheardown, Heather McMaster U. ON Various—eye, cardiovascular


U. Toronto ON Various—neurological: Spinal cord injury, eye; Cancer

Simmons, Craig U. Toronto ON Various—cardiology; Musculoskeletal—bone

Skerjanc, Ilona Sylvia U. Ottawa ON Various—cardiovascular, musculoskeletal

134



disease desCription

Stanford, William U. Toronto ON Various, incl. musculoskeletal—osteoporosis

Sun, Yu U. Toronto ON Various

Turner, Robin Michael Smith Laboratories U. British Columbia BC Various

Tyndale, Rachel U. Toronto ON Various

Unsworth, Larry U. Alberta AB Various

Vincent, Michel U. Laval QC Various—cardiovascular, musculoskeletal

Walus, Konrad U. British Columbia BC Various—musculoskeletal, cutaneous

Wang, Lisheng U. Ottawa ON Various


QC Various


U. Toronto ON Various, incl. cancer, metabolic—diabetes, neurological

Yip, Christopher The Donnelly Centre U. Toronto ON Various


U. Toronto ON Various, incl. hematological

Zhang, Ze U. Laval QC Various

Ziltener, Hermann Johann Biomedical Research Centre U. British Columbia BC Various

3c. Cont’d

3

135

3d. Examples of Researchers Working in Translational Medicine and/or Clinical Trials


universitY/ institution provinCe tYpe of regen. Med disease


U. Ottawa ON Stem cells—hematopoietic Various, incl. cancer—hematopoietic, neurological—MS

Aubin, Jane U. Toronto ON Stem cells—mesenchymal Musculoskeletal



Various—neurological, metabolic—diabetes



Bramson, Jonathan McMaster U. ON Stem cells—cancer Cancer

Couban, Stephen Dalhousie U. NS Stem cells—cord blood Cancer—hematological



Cardiopulmonary


U. Toronto ON Stem cells—hematopoietic Cancer—lymphoma


U. Western Ontario

ON Stem cells—unspecifi ed Neurological—spinal cord injury

Doyle, John U. Toronto ON Stem cells—hematopoietic Cancer



Gassas, Adam Hospital for Sick Children

U. Toronto ON Stem cells—hematopoietic Cancer—leukemia



Eye

Kaplan, David Hospital for Sick Children

U. Toronto ON Stem cells—cancer Cancer




U. Toronto ON Stem cells—unspecifi ed Cancer—hematological


BC Stem cells—unspecifi ed Neurological—spinal cord injury


U. Laval QC Stem cells—hematopoietic Cancer

appendiX3D. EXAMPLES OF RESEARCHERS WORKING IN

TRANSLATIONAL MEDICINE AND/OR CLINICAL TRIALS

136







Mendez, Ivar Dalhousie U. NS Stem cells—fetal Neurological







Morshead, Cindi U. Toronto ON Stem cells—neural Neurological, other





U. Montréal QC Stem cells—cancer Cancer—leukemia


U. Toronto ON Stem cells—cancer Cancer—leukemia


U. British Columbia

BC Stem cells—hematopoietic Cancer—leukemia


U. Calgary AB Stem cells—unspecifi ed Neurological—stroke, spinal cord injury, eye


U. Ottawa ON Stem cells—unspecifi ed Neurological


U. British Columbia

BC Stem cells—hematopoietic Cancer—lymphoma


U. Ottawa ON Stem cells—adult Cardiovascular




BC Stem cells—bone marrow Cancer—hematological


3d. Cont’d

137




U. Ottawa ON Stem cells—unspecifi ed Neurological—spinal cord injury




Wall, Donna Cancer Care Manitoba U. Manitoba MB Stem cells—hematological Cancer



Wong, Peggy Hospital for Sick Children







Mendez, Ivar Dalhousie U. NS Stem cells—fetal Neurological







Morshead, Cindi U. Toronto ON Stem cells—neural Neurological, other





U. Montréal QC Stem cells—cancer Cancer—leukemia




U. British Columbia

BC Stem cells—hematopoietic Cancer—leukemia


U. Calgary AB Stem cells—unspecifi ed Neurological—stroke, spinal cord injury, eye


U. Ottawa ON Stem cells—unspecifi ed Neurological


U. British Columbia

BC Stem cells—hematopoietic Cancer—lymphoma


U. Ottawa ON Stem cells—adult Cardiovascular




BC Stem cells—bone marrow Cancer—hematological


provinCe/ universitY

departMent/affiliated institution url

# asset Map researCHers

# endoWed CHairs

# puBs/sCi. iMpaCt *

alBerta 37 5

U. Alberta All www.ualberta.ca 16 4 116/1.7

Alberta Diabetes Institute www.adi.med.ualberta.ca 1 0 N/A

Other 15 4

U. Calgary All www.ucalgary.ca 21 1 60/1.6

Hotchkiss Brain Institute www.hbi.ucalgary.ca 7 0 N/A

Pharmaceutical Production Research Facility

www.pprf.ca 2 1 N/A

Southern Alberta Cancer Research Institute

www.sacri.ucalgary.ca 1 0 N/A

Other 11 0

BritisH ColuMBia 53 8

Simon Fraser U. All www.sfu.ca 1 0 N/A

U. British Columbia

All www.ubc.ca 50 7 121/1.3

BC Cancer Agency (BCCA) (excl. Terry Fox Laboratory)

www.bccancer.bc.ca 6 1 83/1.9

Biomedical Research Centre www.brc.ubc.ca 6 1 N/A

Centre for Molecular Medicine & Therapeutics

www.cmmt.ubc.ca 1 0 N/A

Child & Family Research Institute www.cfri.ca 1 0 N/A

iCapture www.icapture.ubc.ca 1 0 N/A

Michael Smith Labs www.michaelsmith.ubc.ca 2 0 N/A

appendiX 4 Research Centres Listed By Province

4appendiXRESEARCH CENTRES LISTED BY PROVINCE

138

LIST OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCH CENTRES




# endoWed CHairs


Terry Fox Labs, BCCA www.terryfoxlab.ca 10 1 N/A

Vancouver Coastal Health Research Institute

www.vchri.ca 7 0 N/A

Other 2 0

U. Victoria All www.uvic.ca 2 1 N/A

ManitoBa 11 2

U. Manitoba All www.umanitoba.ca 11 2 N/A

Cancer Care Manitoba (incl. Institute of Cell Biology)

www.cancercare.mb.ca; www.umanitoba.ca/institutes/manitoba_institute_cell_biology

4 1 N/A

Other 7 1

neW BrunsWiCK 1 0

All (New Brunswick Heart Centre) www.ahsc.health.nb.ca 1 0 N/A

neWfoundland & laBrador 1 0

Memorial U. All www.mun.ca 1 0 N/A

nova sCotia 11 1

Dalhousie U. All www.dal.ca 11 1 N/A

ontario 195 41

Carleton U. All www.carleton.ca 1 0

McMaster U. All www.mcmaster.ca 19 5 75/1.1

St. Joseph’s Hospital www.stjosham.on.ca 1 0 N/A

Stem Cell and Cancer Research Institute (SCC-RI)

sccri.mcmaster.ca 7 4 N/A

Other 11 1

Queen’s U. All www.queensu.ca 9 1 N/A

U. Guelph All www.uoguelph.ca 1 0 N/A

U. Ottawa All www.uottawa.ca 34 9 N/A

Ottawa Hospital Research Institute (OHRI) (excl. Sprott Centre)

www.ohri.ca 5 1 N/A

Sprott Centre for Stem Cell Research, OHRI

www.ohri.ca/centres/StemCellResearch

14 5 N/A

University of Ottawa Heart Institute www.ottawaheart.ca 3 1 N/A

Other 11 2

U. Toronto All www.utoronto.ca 110 24 173/1.5

McLaughlin-Rotman Centre for Global Health, University Health Network (UHN)

www.mrcglobal.org 1 0 N/A

Mount Sinai Hospital www.mountsinai.on.ca 1 0 N/A

appendiX 4 Cont’d

4

139

4appendiXRESEARCH CENTRES LISTED BY PROVINCE




# endoWed CHairs


The Donnelly Centre (Terrance Donnelly Centre for Cellular and Biomolecular Research) (incl. Banting and Best Department of Medical Research)

thedonnellycentre.utoronto.ca 8 2 N/A

Hospital for Sick Children www.sickkids.ca 16 4 47/1.2

Institute of Biomaterials and Biomedical Engineering

www.ibbme.utoronto.ca 3 0 N/A

McEwen Centre for Regenerative Medicine, Toronto General Research Institute, UHN

www.mcewencentre.com 12 6 N/A

Ontario Cancer Institute (Princess Margaret Hospital), UHN


19 1 N/A

Samuel Lunenfeld Research Institute, Mount Sinai Hospital

www.lunenfeld.ca 8 3 N/A

Sunnybrook Research Institute sunnybrook.ca/research 12 1 N/A

Toronto General Research Institute (excl. McEwen Centre), UHN

www.uhnres.utoronto.ca/institutes/tgri

3 0 N/A

Other 27 7

U. Waterloo All www.uwaterloo.ca 3 0 N/A

U. Western Ontario

All www.uwo.ca 17 1 N/A

John P. Robarts Research Institute www.robarts.ca 4 1 N/A

Lawson Health Research Institute, London Health Sciences Centre

www.lawsonresearch.com 3 0 N/A

London Regional Cancer Program, London Health Sciences Centre

www.lrcc.on.ca 1 0 N/A

Other 9 0

York U. All www.yorku.ca 1 1 N/A

QueBeC 102 24

École polytechnique de Montréal

All www.polymtl.ca 7 3 N/A

McGill U. All www.mcgill.ca 33 8 89/1.1

Artifi cial Cells and Organs Research Centre

www.medicine.mcgill.ca/artcell 1 0 N/A

Jewish General Hospital incl. Lady Davis Institute for Medical Research

www.jgh.ca 2 1 N/A

Montreal Neurological Institute 1 0 N/A

The Research Institute of the McGill University Health Centre

muhc.ca 5 0 N/A

Other 24 7

U. Laval All www.ulaval.ca 23 1

Centre hospitalier de l’Université Laval

www.crchuq.ulaval.ca 4 0 N/A

140




# endoWed CHairs



www.cha.quebec.qc.ca/en/www/research/fi elds-of-research

www.loex.qc.ca

10 1 N/A

Other 9 0

U. Montreal All www.umontreal.ca 32 10 N/A

Centre de recherche de l’Hôpital Maisonneuve-Rosemont

recherche.maisonneuve-rosemont.org

3 2 N/A

Centre de recherche du Centre hospitalier de l’Université de Montréal

www.chumtl.qc.ca/crchum.en.html

3 0 N/A

Hôpital Sainte-Justine www.chu-sainte-justine.org 2 0 N/A

Institut de recherches cliniques de Montréal

www.ircm.qc.ca 7 3 N/A

Institute for Research in Immunology and Cancer

www.iric.ca 3 3 N/A

Montreal Heart Institute www.icm-mhi.org 2 0 N/A

Other 10 2

U. Québec à Montréal

All www.international.uqam.ca/pages/anglais.aspx

3 1 N/A

U. Sherbrooke All www.usherbrooke.ca 4 1 N/A

sasKatCHeWan 5 0

U. Saskatchewan All www.usask.ca 5 0 N/A

*Publications and scientifi c impact data were produced by Industry Canada in 2010 in a report titled Mapping Canadian BioPharmaceutical Assets. Data were collected from 1996–2009. For the Scientifi c Impact rating, the global average is 1.0.

LIST OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCH CENTRES

appendiX 4 Cont’d

4

141

5appendiXREFERENCES AND NOTES

general inforMation• US National Institutes of Health.

Regenerative Medicine. Department of Health and Human Services. August 2006. stemcells.nih.gov/info/2006report/. Accessed January 21, 2011.

endnotes1 Stem Cell Basics. National Institutes of

Health. stemcells.nih.gov/info/basics/. Accessed January 21, 2011.

2 Till, JE, McCulloch, EA. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiation Res. 1961; 14, 213–222; Becker AJ, McCulloch EA, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature. 1963; 197:452–454.

3 Stem Cell Network. Book Two: Strategic Plan for Second Funding Cycle 2007. Provided by Drew Lyall.

4 www.stemcellnetwork.ca. Accessed December 16, 2010.

5 (1) www.stemcellnetwork.ca. Accessed December 16, 2010; (2) Lyall, A, Isasi, R. Stem Cell Research: Perspectives from Canada. World Stem Cell Report 2010. Chapter 11. pp. 173–177. www.worldstemcellsummit.com/node/663. Accessed December 16, 2010. (3) Industry Canada.

6 (1) Stem Cell Network. Book Two: Strategic Plan for Second Funding Cycle 2007. Provided by Drew Lyall. (2) Industry Canada.

7 Canadian Scientists Transform Human Skin into Blood. www.canada.com/story_print.html?id=3793787&sponsor=. Accessed November 24, 2010.

8 Editorial. Betting on HSC. Nature Immunology. 2002: 3. Cited in Stem Cell Network. Book Two: Strategic Plan for Second Funding Cycle 2007. Provided by Drew Lyall.

9 ISI index reference. Cited in Stem Cell Network. Book Two: Strategic Plan for Second Funding Cycle 2007. Provided by Drew Lyall.

10 Ontario’s MaRS Regenerative Medicine 2009 Industry Briefi ng report. www.marsdd.com/buzz/reports/regenerativemedicine. Accessed November 17, 2010.

11 Technology, talent and capital: State Bioscience Initiatives 2008. Battelle Memorial Institute and Biotechnology Industry Organization. www.bio.org/local/battelle2008/State_Bioscience_Initiatives_2008.pdf. Accessed February 23, 2011.

12 States applaud new stem cell funding. March 11, 2009. www.stateline.org/live/details/story?contentId=383210. Accessed February 23, 2011.

13 (1) See reference #11. Also (2) Fitzpatrick, Meagan. Canada’s mantle as stem-cell leader fading, experts warn. November 2, 2010. www.canada.com/story_print.html?id=3766795&sponsor=. Accessed November 24, 2010. (3) Evidence to Standing Committee on

142

Health Nov 2, 2010. www2.parl.gc.ca/HousePublications/Publication.aspx?Language=E&Mode=1&Parl=40&Ses=3&DocId=4750819&File=0. Accessed December 15, 2010.

14 All NCE funds were dedicated to U. Ottawa where the Stem Cell Network (SCN) is located. A breakdown of funds according to SCN grants across Canada would have made some diff erence to provincial and university funding (Figures 2 and 3), although this generally would not have been signifi cant except for U. Ottawa. Even so, this university would still have ranked among the top fi ve.

15 Stem Cell Basics. National Institutes of Health. stemcells.nih.gov/info/basics/. Accessed January 21, 2011.

16 Shapiro, A.M., J.R. Lakey, E.A. Ryan, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000; 343:230–38. Cited in Lyall, A. Investment Models 3: Public Investment In Stem Cell Research In Canada.

17 Stem Cell Network. Stem cells for the treatment of Parkinson’s disease project. www.stemcellnetwork.ca. Accessed February 7, 2011.

18 www.suite101.com/content/cord-blood-banking-university-research-in-canada-a274345; www.cordbloodassociationofcanada.com/Cord_Blood_Banking.php; Accessed January 28, 2011.

19 v(1) www.canada.com/health/Funding +only+remaining+obstacle+national +cord+blood+bank/3877607 /story.html#ixzz16EF5Hh40. Accessed January 28, 2011. (2) Evidence to Standing Committee on Health Nov 2, 2010. www2.parl.gc.ca/HousePublications/Publication.aspx? Language=E&Mode=1&Parl=40&Ses=3&DocId=4750819&File=0. Accessed December 15, 2010. Note: there was an announcement on March 14, 2011 that governments had agreed to fund a national blood bank with $48 million over the next 9 years with operations expected from 2013. See “National cord blood bank to get $48M”. CBC News March 14, 2011. www.cbc.ca. Accessed March 17, 2011.

20 www.bccancer.bc.ca/NR/rdonlyres/41981E57-778D-4E85-82E2-58D8EE5C16D8/33204/Headlines_Spring_2009.pdf. Accessed February 3, 2011.

21 Ontario’s MaRS Regenerative Medicine Asset Map 2009. www.trra.ca/en/sectors/resources/MRI_asset_maps_RM_050809.pdf. Accessed December 15, 2010.

22 Stem Cell Banks, Libraries and Registries. Stem Cell Network. (Page 4). www.stemcellnetwork.ca/uploads/File/whitepapers/Stem-Cell-Banks-Libraries-and-Registries.pdf. Accessed February 3, 2011.

23 Ontario’s MaRS Regenerative Medicine Asset Map 2009. www.trra.ca/en/sectors/resources/MRI_asset_maps_RM_050809.pdf. Accessed December 15, 2010.

LIST OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE RESEARCH CENTRES5

143

5appendiXREFERENCES AND NOTES

24 www.nce-rce.gc.ca/Media-Medias/news-communiques/News-Communique_eng.asp?ID=93. Accessed January 10, 2011.

25 www.cancerstemcellconsortium.com/uploads/PDFs/CSCC.Full.Str.Plan FINAL REVISED 18 November 2008_Corrected Date.pdf. Accessed January 10, 2011.

26 Information from: stemcells.nih.gov/research/intlresearch.asp, www.vr.se/inenglish/aboutus/internationalcollaboration/globalcollaboration/internationalstemcellforumiscf.4.aad30e310abcb9735780006480.html. Accessed February 3, 2011.

27 Data were obtained from the fi rst 50 hits from Google searches naming province, “research network”, or “research group”.

28 (1) Mapping Canadian BioPharmaceutical Assets: Academic and Hospital Research Institutes (September 2010), internal document provided by Life Science Industries Branch at Industry Canada. Citation data source: Scopus, Website: www.scopus.com. Explanation: Researchers were selected using a formula based on number of papers and citation counts in regenerative medicine and stem cells from 2005 to 2010. Self-citations were excluded. Citation index (h-index) quantifi es the impact of a researcher’s publications. So an h-index of 16 means that the top 16 of a researcher’s articles were cited 16 or more times; an h-index of 12 means that the top 12 articles were cited 12 or more times (Research Performance Measurement: Introducing the SciVerse Scopus h-index). Report published August 2007. www.info.

sciverse.com/UserFiles/2508.SciVerse.Research Performance Measurement(LR).pdf. Accessed January 11, 2011). (2) Report by Science-Metrix for Industry Canada 2010: Performance of Canadian Biopharmaceutical Organizations: A Scientometric and Technometric Analysis (1996–2009), dated March 31, 2010.

29 Canadian Scientists Transform Human Skin into Blood. www.canada.com/story_print.html?id=3793787&sponsor=. Accessed November 24, 2010.

30 Ontario—a leading centre of stem cell research. Biotechnology Focus. 2008; June: 22–25.

31 Nagy, A., J. Rossant, R. Nagy, et al. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA. 1993; 90(18): 8424–28. Cited in Lyall, A. Investment Models 3: Public Investment In Stem Cell Research In Canada.

32 Nagy, A., J. Rossant, R. Nagy, et al. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A. 1993; 90(18): 8424–28. Cited in Lyall, A. Investment Models 3: Public Investment In Stem Cell Research In Canada.

33 Mapping Canadian BioPharmaceutical Assets: Academic and Hospital Research Institutes (September 2010), internal document provided by Industry Canada’s Life Science Industries Branch.

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