campus virchow klinik ardiology science lunch erlin€¦ · a weekly exchange of insights and ideas...
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Cardiology Science Lunch Berlin
Prof. Dr. Dr. med. Frank R. Heinzel Priv. Doz Dr. med. Florian Blaschke Klinik für Innere Medizin m.S. Kardiologie Charité Universitätsmedizin Berlin Campus Virchow Klinik
Prof. Dr. med. Philipp Stawowy Klinik für Innere Medizin und Kardiologie Deutsches Herzzentrum Berlin
Prof. Dr. med. Burkert Pieske Klinik für Innere Medizin m.S. Kardiologie Charité Universitätsmedizin Berlin – Campus Virchow Klinik
und Deutsches Herzzentrum Berlin Klinik für Innere Medizin ─ Kardiologie
Correspondence for Cardiology Science Lunch Berlin to: [email protected]
Wednesday, 4.5.2016
12:00 – 13:00h
Bibliothek at DHZB
PD Dr. Ralf Dechend
Experimental and Clinical Research Center, Charité, Campus Buch
a weekly exchange of insights and ideas in cardiovascular medicine
Campus Virchow Klinik
The following CSLB is on 11.05.2016.
Augustenburger Platz 1, Berlin
x Bibliothek
Cardiology Science Lunch Berlin is sponsored by Servier Deutschland GmbH
Preeclampsia (PE) is a leading cause of maternal death, and perinatal morbidity and mortality resulting from premature delivery and intrauterine growth restriction (IUGR). New onset of hypertension and proteinuria arises secondary to maternal endothelial and inflammatory and immunological dysfunction. Arteriosclerotic lesion develops in the placenta within 9 months and systemic vascular resistance in these patients often exceeds 3000 dyne/cm5m2. Trophoblasts, which are of fetal origin invade maternal vessels against the blood stream and via the interstitium and induce a unique vascular remodeling. Specialized Natural killer cells (uterine NK cells) together with T-cells are regulating this semi-invasive, risky immunological invasion. Together with the remarkable and underappreciated cardiac adaptation process during pregnancy the rapid fetal growth can be accomplished. In preeclampsia something goes dramatically wrong, threatening 3% of pregnant women worldwide with a potential life threating disease....and we do not understand it at all....this is why preeclampsia is called the disease of theories.... However, preeclampsia is not over, when the baby is delivered, since it is now established that preeclampsia predisposes to future cardiovascular disease with an odds ratio similar to smoking.
Preeclampsia – Linking Hypertension and Immunology