campo pearl extract€¦ · japanese cosmetic house, for its natural uv white, a uv protection,...

CAMPO PEARL

EXTRACT

Novel carbon-dioxide lypolized water soluble extract of sea-pearl for novel skin care & skin whitening cosmetics

Novel functional ingredients for

multi-purpose formulations

CAMPO RESEARCH PTE LTD Level 30, 6 Battery Road, Singapore 049909

Tel: (65) 63833203 / 202 / 63833631 Direct Fax (65) 63833632 / 63834034

Email: [email protected] Website: http///www.campo-research.com Internet-Video-Phone Teleconferencing: [email protected] For Technical Assistance

CAMPO® Multi-Purpose Cosmetic Base Chemicals & Active Ingredients

CAMPO® Novel Functional Active Cosmetic Ingredient & Raw Materials

Campo Pearl Extract

CAMPO CD VERSION 3.7.2 dated 23 November 2013 © 2013 Library of Congress Wash.DC 2

INDEX

CAMPOTM

PEARL EXTRACT (PWS)

TECHNICAL SPECIFICATION

MATERIAL SAFETY DATA SHEETS

MATREX

CAMPO SCIENCE BEHIND THE CAMPO PEARL

THE SUN AND THE HARM

Ask about our Herbal Natural Products Chemistry Consultancy Services -Product

Registration EEC/UK New Drug Development (NDA-US); Quasi-Drug Topicals

(MOHW_Japan); Development of Standards, Analysis & Profiles of Phytochemicals;

Literature searches, Cultivation of Medicinal Plants, Clinical-Trials, Development of new

uses for Phytochemicals and Extracts; Contract Research and Development Work in

Natural Products for Novel Drugs, New Cosmetic Active Ingredients for Active Topica/OTC

Cosmetic with functionality and Consumer-preceivable immediate-results, New Food

Ingredients for Nutraceuticals & Functional Foods.

Campo Pearl Extract


CAMPO ACTIVE INGREDIENTS

SONGYI NOVEL SKIN WHITENER NON-IRRITATION-NOVEL NEW SKIN WHITENER

SONGYI OMEGA-HYDROXY ACID AND

SONGYI CERAMIDE COMPLEX NON-IRRITATION AHA-DERIVATIVE WITH NOVEL LIQUID CERAMIDE

CAMPO PEARL POWDER EXTRACT (SURFACE-TREATED PEARL EXTRACT AS NOVEL-

ALTERNATIVE FOR ZINC OXIDE & TITANIUM OXIDE)

SONGYI Biotechnologic RETINOIC ACID

LIGHT & OXIDATION STABLE VITAMIN A ACID FOR SKIN-CARE

MARINE MOISTURISING FACTOR II (CORAL ALGAE-SEAWEED CERAMIDE)

NEW HYDROPHILIC WAX CERAMIDES

WATER-SOLUBLE BIOTECHNOLOGICAL HUMAN SKIN INDENTICAL

WAX-LIKE NOVEL CERAMIDES THAT HAS BOTH THE DUAL

CHARACTERISTICS OF HYDROPHILIC AND HYDROPHOBIC AS THE HUMAN

SKIN CERAMIDES AND FUNCTIONS IDENTICALLY ALIKE TO HUMAN SKIN

CERAMIDES WITHOUT CAUSING CELL-APOPTOSIS (NO CELL-APOPTOSIS

LIKE THOSE CAUSED BY SYNTHETIC & PURE PLANT-ORIGIN

PHYTOCERAMIDES).

Campo Pearl Extract


CampoTM

Pearl Extract (PWS) CAMPO PEARL EXTRACT (PWS) EXTRACT

Day after day, exposure to UV A and UV B creates sun-stressed skin. Dryness causes an

uneven skin tone, radiance fades and skin become tougher. CAMPO Pearl Extract

(PWS), had the 3 answers; viz. UV A UV B repair by moisturizing the already sun-

stressed and damaged skin to recover its youthful radiance and as skin whitener of the sun

browned skin; and further enhancing more protection as novel marine organic filter to the

skin from further future UV induced damage and sun-stress.

CAMPO Pearl Extract (PWS) enhance any skin moisturizer, skin whitener, skin repair

and UV protection cosmetic formulations, with active high performance moisturizer

action, high performance skin-whitening and repair action and high performance UV

repelling actions.

CAMPO Pearl Extract (PWS) is produced from Japan Inland Sea Freshwater Oyster

cells that are cloned and tissue-cultured in industrial biotechnological vats, to secrete Pearl

secretions at regular intervals, and the Pearl secretion are collected before being calcified

or harden; and frizzed-dried and lypholized. Campo's Pearl Extract(PWS) is a natural,

pure and high quality product which has internal uses in Campo, Chinese and Oriental

Traditional Herbal Medicine as well as in Modern Western Cosmetic products.

CAMPO Pearl Extract and various other derivatives of Pearl were first tested in 1988 at

a reputable Japanese University for a multi-national Japanese Drug Co., for Sun-Screen

and Skin self-repair against UV-induced immuno-suppression which caused diseases to

proliferate; such as measles and other viral disease that elicit a rash i.e.; poxes and herpes;

parasitic diseases introduced via the skin i.e. malaria, dengue fever and leishmaniasis; and

some fungal diseases (see UN environmental report 1989 and Update 1991).

As it is now known that unlike the more commonly known threats of skin-cancers and

cataracts which take years of exposure of Sun-UV before being full-blown, UV-induced

immuno-suppression (effects of the sun on the immune system) effects are immediately

damaging. The UV rays affect the skin's ability to detect whether it (skin) is infected by

altering the Langerhans cells, thereby reduce the immune-response to the infection and

allows viruses to attack more easily (see graphic in Sun and The Harm).

The depletion of the ozone layer, has now more effect on the amount of sun-UV reaching

earth, putting population of the world to great-risk of UV-induced immuno-suppression

(according to United Nation doctors who wrote the report and update)( see also UVzymes

literature volume 1, 2, & 3).

Campo Pearl Extract


CAMPO's Pearl Extract (PWS) entirely dissolves in water ( preferably at 70 C ) and 95 -

99% is absorbed by the skin (four times the absorbtivity of the ordinary Pearl-powder); it

consists of complex of amino acids which exists as organic matter and over a dozen of

metal elements: ( via Spark Mass-Chromatograph Analysis )

Calcium (as CaCO3) min 90%

Amino acids min 5.5 - 6.5%

Germanium-organic min. 0.005%

Strontium –organic min. 0.001%

Selenium-organic min. 0.03%

Zinc complex-organic min. 0.10%

Mercury 0.001 ppm max

Other Heavy Metals 0.05 ppb max

Arsenic not detected

Lead 0.80 ppm

Copper 0.19 ppm

Bezoar acid 0.010%

Other Trace Elements 2.00 ppm

Once it is drawn and absorbed into the skin, it is able to nurse and maintain the

skin through participating in enzymatic metabolic activities and promotes the skin growth

of new cells and replenish the surface skin to make the skin smooth, fine, elastic and

naturally white and beautiful. The other main actions are of promoting the activities of

SOD and prevention of the melanin formation ( without inhibiting the melanin formation

but reducing the formation of the dark pigmented melanin into colorless and invisible but

photo-protective functional melanin-known as leuco-melanin) and further whitening the

skin and prevention of skin senility and repair thereof, because SOD has the function of

clearing the skin of cellulite natured toxins. It is also suitable for creams to heal minor

slow healing wounds, removes boils, color spots and blemish. It further acts as an

extension to the exfoliators like Alpha & Beta-Hydroxy Acids, reducing the harshness

caused by the AHA and BHA.

Youthful epidermis after regular applications

With CAMPOTM Pearl Extract (PWS) aqueous solution (1:1 w/v)

See below for continuation of this diagram

Campo Pearl Extract


FFICIENCY TEST

Decreasing of the Trans Epidermal Water Loss (TEWL) in proportionate sequence

decreasing via daily application.

DAY 1 APPLICATION DAY 2 APPLICATION

LITERATURE REFERANCE:

United Nations Environment Programme (UNEP) reports 1989; titled:

Environmental Effects of Ozone Depletion; and its update in 1991.

Dr. Jan van der Leun (author) and chairman of UN Committee on Effects of UV rays

Further reading request for Dr. Balasubramaniam M’s treatise and commentary on UNEP

report 1991 (see sun and the harm)

Cellulite Treatment with Dependance of the Transmittance UV-Damaged Langerhans cells

CAMPOTM Pearl on Filter Concentration (mg per revitalization with CAMPOTM

Solution (1:1 w/v) 100ml) at a cell thickness of 1cm Pearl extr.pws cream

0%

20%

40%

60%

80%

100%

BEFORE AFTER

31%

89%

58% 40

BEFORE AFTER 0

10

20

30

50

60

31%

58%

27%

10

UV-C UV-B UV-C

250 300 350 400

50

100 1mg

2mg

4mg

Wavelength in nm

Campo Pearl Extract


CAMPO PEARL EXTRACT (PWS)


CFTA NAME: PEARL EXTRACT, Natural

INCI NAME: PEARL POWDER

APPEARANCE: Pure White Extra Fine Powder

SIEVE SIZE: > 50 - 85 nm

SOLUBILITY: Aqueous total solution and proper dispersion

(IN WATER)

COMMENTS:

Generic comparison to Sunveil (TIO2-ANATASE; Size 10-20nm) of Ikeda Corp. of Japan.

However, CAMPO's product is totally natural product.

CHEMISTRY Calcium (as CaCO3) min 90%

Amino acids min 5.5 - 6.5%

Germanium – organic min. 0.005%

Strontium – organic min. 0.001%

Selenium – organic min. 0.03%

Zinc complex – organic min. 0.10%

Mercury 0.001 ppm max

Other Heavy Metals 0.05 ppb max

Arsenic not detected

Lead 0.80 ppm

Copper 0.19 ppm

Bezoar acid 0.010%

Other Trace Elements 2.00 ppm

BROAD-SPECTRUM PROTECTION

The advantages of complete safety, absence of recent animal testing, a long history

of use in medicine and cosmetics-albeit for a different function - and the ability to achieve

high sun protection factor (SPF) values and provide broad spectrum protection have all

combined to generate much interest and success in this natural product. UV protection is

dependent on particle size and completeness of dispersion, and the pre-dispersed varieties

remain the easiest to formulate into products.

The optimal size for high SPF values is approximately 50 nm, while for particle

sizes below the size, peak attenuation is in the UV C region. As particle sizes get larger

(>90nm) and peak attenuation shifts towards visible light, towards higher protection is

obtained in the UVA region only.

Campo Pearl Extract


As particle size and complete dispersion is critical to effectiveness, it is obvious

that an oxide (i.e. zinc or titanium oxides) if not properly dispersed in the end-product or if

aggregation occurs on storage, the result will shift towards the visible spectrum of light.

Lack of proper dispersion in a stable end-product and another formulation problem is the

greying of TiO2 caused by UV light; which are promoted by the particle size and the

presence of anatase form of titanium dioxide promote this tendencies, respectively.

Campo Pearl Extract (pws) is a challenge to brought forth to be the answer to the

above described technicalities and as well as to a formulation technical problem faced by a

Japanese Cosmetic House, for its Natural UV White, a UV protection, skin-whitener and

skin-moisturizer (3 in 1) to be incorporated and activeness caused by a single ingredient,

as well as for proper dispersion and to eliminate the greying of the particles on exposure to

UV.

As confidentially restriction(s) applies, the other areas of immuno-re-activation to

the Langerhans cells that are already affected by immuno-suppression actions of UV could

not be elaborated here in this technical specification. As immense confidential clinical

data are available for the various activities, but due to difficulties in patenting this natural

product has shelved this product for time-being, which product was researched as an

answer to the problems and afflictions potentials described in the UNEP report 1989 &

Update 1991.

FORMULATION GUIDELINES:

SKIN MOISTURIZERS CREAMS & LOTIONS: 1 - 5 %

SUNSCREENS/UV PROTECTION PRODUCTS 10%

SKIN WHITENER PRODUCTS 10%

TOLERANCE TESTS:

SKIN IRRITATION None

EYE IRRITATION None

LD50 MICE 6.03 gm/kg of body weight

(Regarded as edible

supplementary health diet)

AMES TEST Non-Mutagenic

Campo Pearl Extract


CAMPO RESEARCH Pte Ltd


PRODUCT Name (Campo Research)

Other Trade Names (Campo Research)

CTFA TRADE NAME

Existing CTFA/INCI Name

Chinese Translation

CAMPO PRODUCT #

HS Code:

CTFA Monograph ID:

CAS NO#

CAS NO# EU

EINECS Number and Name

EINECS# EU


Pearl Essence; Pearl Essence Extract; Perles Essence


Pearl Powder

珍珠粉 (PEARL POWDER)

95-155 B

1302.19.0000

10722

N/A – Pearl Powder

N/A - Margarita Powder

N/A - Pearl Powder


SPECIES Margaritifera margaritifera Linn.

Syn: Margaritifera margaritifera Linn.

PARTS USED Pearl calcus

RAW MATERIAL - ORIGIN JAPAN

CONCENTRATION 200:1

Specification Parameter Analysis Specification Range Methods

Physical Form Pure White Powder, extra fine Visual

Colour White to white buff Visual

Odour Almost Odorless Olfactory

Specific Gravity (20°C) 1.050 – 1.150 (1gram dissolved in 10ml

water) USPXXIV/Paar,DMA35

Refractive Index (20°C) - USPXXIV/DGF IV C (52)

pH(20deg.C.) (100% concentrate) N/A USPXXIV/DGF H III (92)

Calcium (As Ca Co3) Min. 90% -

Amino Acids Min. 5.5% -

Solubility Not Water Soluble but completely Water

dispersible (With Slight Cloudiness) -

Germanium Organic Min.0.005% USPXXIV/Ph.Eur.2.6.12(97)

Strontium Organic Min.0.001% USPXXIV/Ph.Eur.2.6.12(97)

Selenium Organic Min.0.03% USPXXIV/Ph.Eur.2.6.12(97)

Zinc Complex Organic Min.0.10% USPXXIV/Ph.Eur.2.6.12(97)

Mercury 0.001ppmMax USPXXIV/Ph.Eur.2.6.12(97)

Arsenic Not Detected USPXXIV/Ph.Eur.2.6.12(97)

Lead 0.80 ppm USPXXIV/Ph.Eur.2.6.12(97)

Copper 0.19 ppm USPXXIV/Ph.Eur.2.6.12(97)

Bezoar Acid 0.010% -

Other Trace Element 2.00 ppm -

Dry Residue (160deg.C/34Min) N/A -

Preservation None Mettler 16J

Pesticide Content None Pflanzaniaschuttal1989

Total Germs <10 CFU/ml - non pathogenic -

Total Yeast/Mold Nil USPXXIV/Ph.Eur.2.6.12(97)

Heavy Metals(Total)As,Pb,Hg <0.05 ppm USPXXIV/Ph.Eur.2.6.12(97)

CAMPO RESEARCH Pte. Ltd, SINGAPORE

CAMPO RESEARCH USA, INC SAN DEIGO CA 92111, & Manhattan, New York City, USA

CAMPO RESEARCH s.r.o., Brno, Czech Republic

CAMPO RESEARCH Pvt. Ltd, CHENNAI , INDIA MATERIAL SAFETY & CONSUMER SAFETY TESTING LABS.

DIV. OF JTC KAMPOYAKI SINGAPORE

EMERGENCY MATERIAL SAFETY / ACCIDENTAL RELEASE CENTER Contact:

Emergency Tel.no: +(65)-3833202/3833631(24hours) /3228551/3228503

Emergency Fax No: +(65)-3833631(24hours), 3824680, 3228558

EMERGENCY PC-VIDEO-TELECONFERENCING: [email protected]

EMAIL:[email protected]

Campo Pearl Extract


MATERIAL SAFETY DATA SHEETS

CONFIRMS TO EC DIRECTIVE 91/155/EEC, EC REGULATION

NO#1272/2008, AMENDED EC REGULATION NO#790/2009 and Complies

toThe EU Cosmetic Products Regulation (Regulation (EC) No 1223/2009)

effective on July 2013., AND to US DEPT.OF LABOR-Occupational Safety

& Health Admin directives and compliant to Globally Harmonized System of

Classification and Labeling of Chemicals

(hereinafter referred to as “the GHS”).

http://www.osha.gov/dsg/hazcom/ghs.html

http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html

http://www.hc-sc.gc.ca/ahc-asc/intactiv/ghs-sgh/index-eng.php

DATE OF FIRST ISSUE

DATE OF LATEST REVISION

February 10th 1992-Reviewer -

Dr Balasubramaniam PhD

Dec. 10th 1996- Rev’wer-

Dr Fergus Jes .G.Velasquez Bsc. Med Tech, MD

April 12th

2004 Mr TEO SH

February 10th

2012 – Reviewer=Joshua Teo

February 5th

2013 – Reviewer =

Balasubramaniam M PhD

1 PRODUCT AND COMPANY

IDENTIFICATION

COMMERCIAL NAME:

OTHER TRADE NAME:

LATIN NAME:

C.I. Index

INCI NAME USA

INCI EU

Chinese Translation

INTERNATIONAL CHEMICAL

IDENTIFICATION

(EC REGULATION NO#1272/2008

AMENDED NO#790/2009)and Compliant

to the GHS

EPA (USA) GENERIC NAME:

MANUFACTURER:

(cGMP MFG. FACILITIES) :

EMERGENCY TELEPHONE NUMBERS:


Pearl Essence; Pearl Essence Extract;

Perles Essence, Campo Pearl Powder

Margaritifera margaritifera Linn. Cl 75170

Pearl Extract

Margarita Powder

珍珠粉 (PEARL POWDER)

Margarita Powder

Pearl Extract

CAMPO RESEARCH Pte Ltd

Level 30, 6 Battery Road,

Singapore 049909.

(65)-63833631/(65)-63228503 (Singapore)

2 HAZARDS INDENTIFICATION

NOT CLASSIFIED AS DANGEROUS

ACCORDING TO DIRECTIVE 67/548/EEC OR

ITS AMENDMENTS.

HAZARD CLASS and CATEGORY CODE(s)

HAZARD STATEMENT CODE(s)


AMENDED NO#790/2009) and compliant to

the GHS

GHS CLASSIFICATION :

This material is Non-hazardous according

DIVISION 1.6; NON-HAZARDOUS

NO HAZARD STATEMENT

PICTOGRAM : NONE

No GHS Pictogram (Totally Non-Hazardous

Division

1.6; NO HAZARD STATEMENT

PICTOGRAM : NONE


Campo Pearl Extract


To UN-GHS Criteria.

GHS LABEL ELEMENTS:

Division 1.6: No Hazard Statement.


Division 1.6: No Hazard Statement.

3 COMPOSITION / INFORMATION ON

INGREDIENTS

100 PERCENT CARBON DIOXIDE GAS

EXTRACTED PEARL CALCUS SECRETION

WATER-INSOLUBLE COMPONENTS &

FREEZED-DRIED.

CTFA Monograph ID:

CAS NO#

CAS NO# EU

CAS NO# (CAS Name)


AMENDED NO#790/2009)and compliant

to the GHS

EINECS Name and Number

EINECS# E

EINECS# (EINECS Name)


AMENDED NO#790/2009) and compliant

to the GHS

RISK PHRASES

SAFETY PHRASES 25-26

GHS CLASSIFICATION :

This material is Non-hazardous according

To UN-GHS Criteria.

GHS LABEL ELEMENTS:

Pearl Calcus

10722 - Pearl Powder (Margarita Powder)

N/A

N/A


N/A - Pearl Powder



None

Not Mandatory

PICTOGRAM : NONE


Division 1.6: No Hazard Statement. 4 FIRST AID MEASURES

EYE CONTACT:

ORAL INGESTATION:

SKIN CONTACT:

Wash with water or standard eye wash solution.

Seek medical advice, if irritation occur and

persist.

Edible in small quantity (10 gms) without

adverse effects.

Wash with water or shower.

5 FIRE FIGHTING MEASURERS

NON-COMBUSTIBLE AND PRESENTS NO

SPECIAL FIRE HAZARD.

EXTINGUISHING MEDIA:

PROTECTIVE EQUIPMENTS FOR

FIGHTERS:

Treat as oil fire when store in HDPE drums with

CO2, dry foam or dry chemical.

Standard Equipments.

6 ACCIDENTAL RELEASE MEASURES

ABSORB ONTO AN INERT MATERIAL AND

SCRAPE UP. REMOVE RESIDUE BY

SCRUBBING WITH HOT WATER OR

DETERGENT SOLUTION.

7 HANDLING AND STORAGE

STORE IN SEALED CONTAINERS UNDER

NORMAL COOL, DRY WAREHOUSING

CONDITIONS.

8 EXPOSURE AND PERSONAL PROTECTION

IN ACCORDANCE WITH GOOD

Campo Pearl Extract


INDUSTRIAL PRACTICE AND HANDLING

USING STANDARD EYE PROTECTION. USE

OF PROTECTIVE MASK FOR DUST

PARTICLES.

9 PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL FORM:

COLOUR:

ODOUR:

BOILING POINT:

MELTING POINT:

VISCOSITY:

FLASH POINT:

FLAMMABILITY SOLID/GAS:

AUTO FLAMMABILITY:

SPECIFIC REFRACTIVE:

EXPLOSIVE PROPERTIES:

pH:

OXIDIZING PROPERTIES:

VAPOUR PRESSURE:

DENSITY:

WATER SOLUBILITY:

OTHER SOLUBILITY:

BULK DENSITY:

PARTITION COEFFICIENT:

(OCTANOL/WATER)

EXPLOSIVE LIMITS:

Pure White Powder, extra fine

White to white buff

Almost odorless

-

-

-

-

N/A

N/A

-

N/A

N/A

N/A

N/A

-

Not Water Soluble but completely Water

dispersible

Partially in most volatile cosmetic solvents

-

-

-

10 STABILITY AND REACTIVITY

THERMAL DECOMPOSITION: Stable under normal conditions of use.

11 TOXICOLOGICAL DATA Animal Tests Last Done 1992, as requirements

of the then EC DIRECTIVE 91/155/EEC

ORAL: (Year 1993)

DERMAL:

INHALATION:

SPECIFIC CONCENTRATION LIMITS

M-FACTORS


AMENDED NO#790/2009) compliant to

the GHS.

LD50 > 36,000 MG/KG (Body Wt.) Rat

Essentially Non-Toxic and Edible in Small

Quantity.

Expected To Be Essentially Non Toxic.

Slight Ethanolic Sting – irritation

36,000MG/KG (Body Wt.); CATEGORY 5

Essentially Non-Toxic and Edible in Small

Quantity.

TOXIC EFFECTS:

SKIN:

EYE:

Primarily Irritation Index (PII) = 0.0 ( Non-

Irritating - Skintex ), Not A Primarily Irritant.

Non-irritant / Non-sensitizer as per Repeated

Patch Insult Test on 50 Human volunteers.

Human Repeated Patch Test 48 hours:

50/50 completely non-irritating / non-erythema

causing ingredient at 10% concentrate in

water on 50 human volunteers

Very Mild/Minimal - Not A Transient

Conjunctival Irritant at 10% concentrate in

water (Eyetex - Eyetex classification ).

Summarized toxicological data as shown here are formation

bounded under Non-Disclosure Agreement with various

clients as when these Toxicological Data were established or their exclusive uses.

Campo Pearl Extract


12 ECOLOGICAL INFORMATION

BIODEGRATION:

FISH TOXICITY:

BACTERIAL & VIRAL TOXICITY:

WGK CLASS:

Expected To Be Ultimately Biodegradable.

No Data

No data

WGK (Self Classification)

13 DISPOSAL CONDITIONS

DISPOSE OFF ACCORDING TO A

RECOGNISED METHOD OF CHEMICAL

WASTE DISPOSAL.

14 TRANSPORT INFORMATION

UN NUMBER# :

UN NAME:

IMDG CODE/CLASS:

IMDG CODE PAGE NO.

ICAO/IATA AIR CLASS:

ICAO/IATA AIR CLASS PACKING GROUP:

RID/ADR CLASS:

ADNR CLASS:

LABELLING:


AMENDED NO#790/2009) and compliant to

the GHS.

PICTOGRAM SIGNAL WORD CODE(s):

HAZARD STATEMENT CODE(s):

SUPPLEMENTARY HAZARD

STATEMENT CODE(s):

N/A

Not Assigned

Not Hazardous

N/A

Non-Hazardous

N/A

Non-Hazardous

Non-Hazardous

No GHS Pictograms (Totally Non-Hazardous)

Division 1.6; No Hazard Statement

Similar Division 1.6; No Hazard Statement

15 REGULATORY INFORMATION

OCCUPATIONAL EXPOSURE LIMITS: N/A

16 OTHER INFORMATION

USES AS A COSMETIC ADDITIVE

This format and information is compiled by

Kampoyaki Novel Natural Product Chemistry/ Novel

Drug Discovery cGMP Labs Kobe, Japan;

for Campo Research, Kyoto and Singapore.

0.01 - 50.0 %

*Please take note that all specifications are

liable to changes without prior notice.

Campo Pearl Extract


MATERIAL SAFETY AND CONSUMER PRODUCT

SAFETY TESTING LABS

(DIVISION OF JTC KAMPOYAKI, SINGAPORE)

P.O.BOX 2105, SINGAPORE 9041

REPUBLIC OF SINGAPORE

FINAL REPORT

DIVISIONAL/COMPANY/GROUP MESSRS ONES/CHEMICAL DIVISION

ATTENTION Mr. D.H.Lee

TEST the Matrex in Vitro Toxicity Testing System,

Salmonella Typhimurium Reverse Assay

TEST ARTICLE CAMPO PEARL EXTRACT (PWS)

EXPERIMENT REFERENCE NO: 1994 - 9 -14

_____________*______________

P.S. Mary

Director of Microbiology

____________*________________

V.Devi

President

Laboratory Director

Date: September 18th 1994

*no-signature-required–computer-generated.

Campo Pearl Extract


OBJECTIVE

To evaluate the test article for irritancy potential utilizing the MATREX in vitro toxicity

testing system.

INTRODUCTION:

TESTSKIN and MATREX are sophisticated in vitro systems. Developed in

Organogenesis Inc. of Cambridge, Massachusetts, they closely mimic human skin in

structure and function. The Living Dermal Matrex (LDM) consists of a three-

dimensional construct comprised of living cells in a collagen matrix. Nutrition is provided

through the base via a permeable membrane, leaving the surface open to the atmosphere.

This makes an ideal system for applying a variety of materials, including liquids, powders,

oils, gels and creams.

The Living Skin Equivalent (LSE) has all the features previously described, plus the

formation of an actual epidermis complete with stratum corneum.

TESTSKIN and MATREX, when used with the recommended cell metabolism assay, can

quickly provide toxicological profiles. The procedure involves a solubilized, reactive

tetrazolium (MTT), which is metabolized by the mitochondria of living cells and

converted to a purple formazan dye. The color intensity of the skin replica extract

measured photometrically, correlates directly with its viability. When measured against

controls, values ranging from 0% to 100% (plus minus approximately 20%) can be

calculated for each dose of an applied substance.

Text Article: PEARL EXTRACT 1 GM IN 1 ML WATER

SOLUTION (1.1 w/v)

Reference Articles: PROPYLENE GLYCOL & MORPHOLINE

METHOD:

The appropriate dilutions of test sample and control articles were applied to MATREX.

After the appropriate exposure period, the articles were rinsed from the MATREX

surfaces. MTT (tetrazolium salt) assay medium was utilized in order to quantify cell

metabolism. At the end of the staining period, excised portions of each MATREX were

immersed in acidified isopropanol, which extracted the converted MTT from the tissue

samples. A Dynatech MR 4000, Automatic Microplate Reader was used to determine the

absorbance of each extract at 570nm. With the absorbance of a negative control defined

as 100% the percent absorbencies of the test and control articles were determined. The

percentages listed below directly correlate with the cell metabolism in the MATREX

samples.

Campo Pearl Extract


RESULTS:

Test Article Percent Percent

(% & Exposure) System Viability Inhibition

PEARL EXTRACT 1 GM IN 1ML WATER (1.1 w/v) SOLUTION

(100% - 1 hr) LDM 99.9% 0.1%

(10% - 1 hr) LDM 100% -

(1% - 1 hr) LDM 100% -

Propylene glycol

(100% - 1 hr) LDM 73% 27%

(10% - 1 hr) LDM 99% 1%

(1% - 1 hr) LDM 96% 4%

Morpholine

(100% - 1 hr) LDM 6% 94%

(10% - 1 hr) LDM 4% 96%

(1% - 1 hr) LDM 100% 0%

HISTORICAL IN VITRO RESULTS:

Propylene glycol has historically been categorized as virtually non-irritating when tested

using the Draize irritation methodologies. Morphine has been categorized as moderately

irritating when tested in the same manner.

DISCUSSIONS:

The sponsor-submitted elicited in vitro results comparable to those recorded for propylene

glycol

CONCLUSION:

The results indicate that the sponsor-submitted product has virtually no irritation potential,

under the conditions of the test.

Campo Pearl Extract


CCR - Cytotest Cell Research

CCR PROJECT 94/32

SALMONELLA TYPHIMURIUM

REVERSE MUTATION ASSAY

REPORT

Study Completion Date:

Sept. 23, 1994

Campo Pearl Extract


Test Report CCR Project 94/32

CONCLUSIONS

The test article Pearl Extract (PWS) was assessed for its potential to induce gene

mutations according to the plate incorporation test (experiment I) and the pre-incubation

test (experiment II) using Salmonella typhimurium strains TA 1535, TA 1537, TA 98, TA

100 and TA 102.

The assay was performed in two independent experiments both with and without

liver microsomal activation. Each concentration, including the controls, was tested in

triplicate. The test article was tested at the following concentrations:

33.3; 100.0; 333.3; 1000.0; 2500.0; and 5000.0 ug/plate

No toxic effects occurred in the test groups with and without metabolic activation

in experiment I and II in all strains is used.

The plates incubated with the test article showed normal background growth up to

5000.0ug/plate with and without S9 mix in all strains used.

No substantial increases in revertant colony numbers of any of the five tester

strains were observed following treatment with Pearl Extract (PWS) at any dose level,

either in the presence or absence of metabolic activation (S9 mix). There was also no

tendency of higher mutation rates with increasing concentrations in the range below the

generally acknowledged border of significance.

A slight decrease (0.0001%) in revertant colony numbers was observed in strain

TA 102 at 333.3 and 1000.0 ug/plate in experiment I in the presence of metabolic

activation. However, this effect is considered not to be relevant since it could not be

reproduced in the normally more sensitive pre-incubation assay.

Appropriate reference mutagens were used as positive controls and showed a

distinct increase in induced revertant colonies.

In conclusions, it can be stated that during the described mutagenicity test and

under the experimental conditions reported, the test article did not induce point mutations

by base pair changes or frameshifts in the genome of the strains used.

Campo Pearl Extract


CAMPO SCIENCE BEHIND THE CAMPO PEARL BIO-ENGINEERED PEARL

Campo Pearl Extract


CAMPO SCIENCE BEHIND THE CAMPO PEARL EXTRACT (PWS) Pure Pearl Extract in Lypholized State

Campo Pearl Extract


CAMPO SCIENCE BEHIND THE CAMPO PEARL EXTRACT (PWS) A Pictorial Efficiency of Skin Whitening and UV-Protection Effect

BEFORE Sun-tanned volunteers with sun-browned skins Before the application of Campo Pearl Extract Based Crème

Campo Pearl Extract



AFTER 2 weeks application of 10% Pearl Extract Crème all over the Body and facial skin, 2 times daily. A lightened skin becomes pronounced based on skin whitening and protection from sun and UV caused skin darkening.

Campo Pearl Extract



Campo Pearl Extract



AFTER 8 WEEKS Total lighten skins with 10% Pearl extract crème all over body and Facial skin, 2 times daily The protection effect form sun and UV Bronzing becomes very clearly effective.

Campo Pearl Extract


THE SUN

AND

THE HARM

Sunshine lovers, beware. Even if the hole in the ozone layer is far way

more dangerous ultraviolet rays pour into areas near the Equator, like

Singapore, than elsewhere because of it. It affects your skin -

immediately we know. But how, we don’t. So it may be better to be safe

in the shade than sorry in the sunlight.

The sun that heat The burning sensation it caused on the arms after a short walk in the late

morning could eventually cause skin cancer and cataracts after several years of exposure.

But now there is a new worry. And it is immediate.

New research suggest that staying out too long in the sun today could ruin the body’s chances of

fighting off some diseases as soon as tomorrow.

In a United Nations report released recently, scientists warn that that sun’s ultraviolet (UV) rays

may affect the body’s Immunological system by altering some cells in the skin.

This could cause infections that come through the skin to go unchallenged by the body at an early

stage, says the United Nations Environment Programme in its report, Environmental Effects of

Ozone Depletion : 1991 Update.

The earlier 1989 report elaborated on the large number of diseases that might be affected by UV-

induced immunosuppression.

Examples of such diseases include:-

* Measles and other viral diseases that elicit a rash, such as chicken pox and herpes,

* Parasitic diseases introduced via the skin such as malaria and dengue fever and an

infection called leishmaniasis, which is transmitted by the sand fly and

* Some fungal infections. Unlike the more commonly known threats of skin cancer and

Cataract, which are require years of exposure to the sun, the effects of sunlight on the

immune system are almost immediate, say the UN doctors.

Another concern is that while pigmentation, or skin color, may help ward off skin cancer, it

appears to have no use in protecting the skin form damage to the immune system.

In other words, as the latest UN report puts it: “All the world’s population is at risk of the potential

adverse impacts of (ultraviolet rays) on the immune system”.

Campo Pearl Extract


The bad news for Singaporeans is that they are among the most at risk because the thinning ozone

layer lets in a lot more UV in the tropics than even in the places where is a hole in the ozone layer.

Unfortunately, this added risk in the tropics is not reflected by increase research on the health

effects, or even monitoring of how much UV reaches the country (see other story).

What little research there is overseas shows that the damage to the immune system is possibly the

biggest risk of all.

After all, sunglasses can help protect against cataracts, and sunblock and skin color can help

protect against skin cancer; but what protection is there against the damage to immune system?

Dr Jan Van Der Leun, a leading Dutch scientist who chaired the UN committee that looked into

the effects of UV rays, and co-authored the report, elaborated on it when he spoke to The Sunday

Times by telephone from the Netherlands.

He said, “In the previous report (1989), we based our conclusions on our experiments on animals.

In the meantime, there have been observations that similar effects occur in humans. Our research

now is closer to the real world.

“We are one step closer now to the conclusion that people will suffer from the suppression of the

immune system by UV rays.”

One arguably pleasant effect of the damage to the immune system is suppressed,” Dr Van Der

Leun pointed out.

A mosquito bite, for example, would itch less, meaning that the skin is not alerting the body’s

defense mechanism, and the infection could worsen before the body defends itself.

The UN reports make it clear that “the activation of viruses by UV is unlikely to result in an

increased rate of infection. Instead it would result in the increased severity of the disease, or a

more rapid course of infection.”

In Singapore, a skin expert from the National Skin Centre confirmed that UV rays are known to

affect the immune system. but cautioned that there is still much to be known about how the

immune system responds to infection.

Dr Tham Siew Nee, consultant dermatologist at the NSC said, “The date in the UN report is

correct. But although we know that UV rays appear to cause a change in the immune system,

whether or not it means the body’s overall response to infectious diseases is affected, I don’t

know”.

“There are a lot of other factors to be taken into account. For example, the change in the immune

systems may be temporary”.

Dr Van Der Leun, too, counselled caution, saying, “The findings on the health effects are all from

small groups in small research programmes. There is no large institute looking into this area or

finding, and that is one of the problems.”

But he added, “However, we know there is a real relationship between the UV and the immune

system. Damage is almost immediate and we can see some of the damage in a day or a week.”

He said the findings so far suggested that the effect on the immune system was restricted to that

portion of the skin, which has been exposed to UV rays.

He added, “It does not apply to the body’s total immunity in general.”

Campo Pearl Extract


That was a point also taken up by Associate Professor Susan Lim of the National University

Hospital, who holds a PhD in Immunology. She said, “The situation is not so bad, or we would be

walking around with cancers and leukemia.

“Furthermore, the skin may be the entry point of an infection, but the body’s immune system is

made up of more than just skin; it includes the blood, the spleen, the bone marrow and so on.”

She added, “It is proven tin the lab that UV radiation alters Langerhans cells and paralyses their

function. For instance, if you put them in a bowl and irradiate them with UV, their metabolism is

altered.

“But as for how they react in the skin to UV rays - whether, for example, pigmentation helps to

combat damage - I don’t know.”

But some studies done in the United States and Australia indicate that a darker skin color is no

protection from immune damage.

The Australian study found that low doses of UV rays, not even enough to cause a sunburn,

managed to affect the body’s resistance to disease of not only Caucasians, but also Asians and

Aboringes.

A later study from Miami, Florida, published last year by the Society For Investigative

Dermatology said, “UV-susceptibility exists as a trait in individual with genetically determined

black skin, as well as individuals with heavily tanned skin, and the incidence of this trait is similar

to that found among normal Caucasian subjects.”

So the debate on whether UV rays hurt the skin’s immune system boils down to this:

THE FACT: It is known and accepted that UV rays alter the ability of Langerhans “spy” cells to

warn the body of infection. That has been amply demonstrated.

* THE UNCERTAINTY: Now, a few small-scale studies around the world have shown

that the Langerhans cells in the human skin fail to warn the body of infection after they

have been exposed to UV rays.

* THE BIG WORRY: With the depletion of the ozone layer, it is probable that more UV

rays than normal will pour through the sky. How will the body’s immune system cope with these

extra UV rays?

The only way to resolve these issues is to initiate more studies on them.

But, meanwhile, common sense dictates that where there is the most sunlight there is that much

more heat and that much less inclination to wear clothes that cover the whole body.

So people in the tropics not only have to live more UV rays coming in, but also tend to expose

themselves to it more.

The only known way to combat the immune suppression effect to sunlight at this point is to adopt

“protective behavior”, such as staying indoors or wearing full-length clothes, says Dr Van Der

Leun.

So while he also adds the caution that “it is very difficult to pinpoint a radiation relationship to

ozone depletion,” the question remains: what to do when that arm starts tingling with a burning

sensation on a late, bright morning?

The answer has to be it is better to be safe on the shade than sorry.

Campo Pearl Extract


What little research there is overseas shows hat the

damage to the immune system is possibly the biggest

risk of all. After all, sunglasses can help protect against

cataracts, and unblocks and skin color can help protect

against skin cancer, but what protection is there against

the damage to the immune system?.

Campo Pearl Extract


THE HUMAN SKIN

LIGHT

HORNY LAYER

Prickle Layer

(with melanin

granules)

Dermis Blood System

White Light scattered

Brown light reflected

Red light reflected

Yellow light reflected

Campo Pearl Extract


SKIN WHITENING EFFECT OR CAMPO PEARL EXTRACT (PWS) AN UNIQUE NEW NOVEL BIOTECHNOLOGY ADAPTOGENIC MULTI-FUNCTIONAL COSMETIC INGREDIENT THAT DEFIES THE KNOWN PARAMETERS OF ALL SYNTHETIC SKIN WHITENING AND SUN & UV-PROTECTION AGENTS & CHEMICALS; WHITEN WITH ITS' (PWS) UNIQUE PROPERTIES AND CONFERS IRREVERSIBLE SKIN-TONED-WHITENING, AFFORDS A BIOLOGICAL SUN & UV-PROTECTION AND REVERSE UV-DAMAGED, AND REVERSE UV-DAMAGED IMMUNE SYSTEM TO FUNCTION AT ITS OPTIMAL AND NORMAL ACTIVATION LEVEL(S).

INTRODUCTION We need to refresh on the structure of the skin (see figures of skin) and understand the metabolism(s) of skin-whitening activity and its (skin-whitening) effect contrast to the UV-A induced skin darkening effect (i.e.: melanin synthesis) process at the Melanocytes cells (dentritic cell(s). Both processes (i.e.; skin whitening and UV-A induced skin darkening) begins at the Melanocytes and most current synthetic cosmetics materials used for skin-whitening address only one function primarily. Therefore, we begin at UV-protection effect and dwell into the Skin-Whitening effect, to reflect perfect understanding from our clients of our novel Campo Pearl Extract, (PWS) and the mechanisms involved for UV Protection, Skin-Whitening and Reversing of Damage to the Immune System by harmful UV-inducement. The pigment Melanin is synthesized at Melanocytes at the Basal layer level and this level is further also responsible for the re-generation of the Epidermis (including the Horny

Campo Pearl Extract


layer or Stratum Corneum). This melanin production is increased by the level of UV-A light falling on the skin, this production and its (melanins') importance are of two-fold, (namely the first the melanin pigments affords a short-term protection of the deeper layers of dermis against immediate damage by ultra-violet B radiation and secondly, in the long term it affords protection against cancer (from UV-induced genetic damage to the normal cells which turn into malignant and cancerous growth). (1). The Melanin synthesis is synthesize in several stages, starting with the synthesis of pre-melansomes in the Golgi body of the Melanocytes (see figure of cell structure). The endoplasmic reticulum of the Melanocytes contains the amino-acid tyrosine, which oxidized by copper containing enzymes known as tyrosinase found in the pre-melanosomes, through a sequence of several steps to produce melanin as the final product (see summarized steps below, in this paragraph). The colorless pre-melanosomes are promoted further away from the cell-nucleus (as seen in figure of cell) by the dendrites (dentritic growth is analogous to a octopus tentacles moving far way from the parent body) During this dendritic growth, the pre-melanosomes (in the dendrites) are converted to melanosomes and further darken into melanin form (contain in these dendrites) and these dendrites (with the new-formed melanins) are absorbed by the surrounding prickle layer (or Stratum Granulosum) Cells and the melanin passes into these cells from tips of the dentrites, thus pigmenting them. To summarize the biological pathway resulting in Melanogensis (i.e.; formation of Melanin as proposed by Mason & Raper (2), the key steps in this reaction process are the hydroxylation of Tyrosine to DOPA-(1,4, dihydroxyphenylalanine) and the oxidation of DOPA to dopaquinone by means of the catalytic action of the enzymes tyrosinase, a copper-containing oxidase (enzyme). At the stage above described, when PWS is absorbed thru the skin - a novel process take-place which is similar to the action of ordinary Pearls consumed orally (after ingestion & transmitting the gastro-intestinal organs, becomes deposited in cellular mechanisms of various organs including the skin - the largest of the organs). The germanium (3) ( a trace-element found ordinarily in Pearl, which is biologically soluble and readily bio-available in PWS) plays a novel multi-functional part both as an oxygen increasing and much more-uptaking - natural element during the oxidization process of the amino-acids tyrosine upon saturation point of the oxidation - a reverse-process of de-oxidizing mechanism then occurs ( osmosis )that return the darken melanin in to the colorless form (as colorless to almost colorless melanins-leuco-melanin) as it(melanin) exists (colorless) in pre-melanosomes and melanosomes stage, while another activity is spontaneously conducted - (by organic germanium) - that of protecting the cellular tissue from the highly reactive extra oxygen (free-radicals). These highly reactive molecules that can react with important substances in the human body, causing great damage (this control of free-radicals by germanium is also noted during the remedial reverse of UV-damaged immune system into a normal functioning immune system, and free-radicals are known to be released during regular or during reversed up & toned up-normal immune stimulation activity (also see the other paper on revitalization of Langerhans cells). Briefly to mention, organic germanium conduct and support cellular semi-conduction, and the cellular semi-conduction increases the UV –injury repair function in combination with the non-UV mutated p53s. p53s are also benefited by the presence of organic germanium in the cellular membrane to pump ions back and forth, and in and out of the skin cells, without being zapped and mutated ( p53 by the UV).

Campo Pearl Extract


SIGNAL TRASDUCTION OF CELL PROLLFERATION (April, 1994)

Campo Pearl Extract


The PWS acted upon- colorless or almost colorless melanin pigments are channeled the same manner via dentritic (of Melanocytes) to the prickle layer and absorbed to be further keratinisation and desquamation when at the keratinisation and desquamation stage in skin surface layer (it should be briefly noted here that the ) PWS's nutrients in the enriched surface cells, enrich the epidermis & dermis for a few different separate but symbiotic functionalities such as:- A. enriching the "surface acid-mantle" of the skin (By Selenium (a trace element

in PWS) and its functions are enriching the nature of chemical debuffering, detoxifying & bacteriostatic action - of the acid mantle) and it derivatives are reflectors of UV rays;

B. - by the actions of PWS's (see below) functionalities; C. - the other actions is enrichment of the metal ions, amino acids (both

absorbed by the skin and released to the surface of epidermis thru the cells which after the desquamation process leaves a rich, TEWL protective barrier of water absorbing amino-acids'reservoir etc), which provides for smooth supple skin conditions.

D The PWS Strontium (another trace element) in its various forms function as a dekeratinisation substance of the desquamated skin cells to form a light protective lipid barrier that scatter the white light from the skin surface and reflects the respective color band of light at the deeper levels of the epidermis - dermis (see diagram on Light being reflected from skin).

As described above, the PWS's dual functions of UV-protection and Skin-Whitening effect are inseparable but yet a major separate but spontaneously Skin-Whitening effect is further being in process at the level to be discussed below. The biologically soluble amino-acid Gluthathione (in PWS) further also involves in the reverse of darken melanin to colorless or almost colorless (in simultaneous action to the action of Germanium) but as previously discussed above and again here these PWS actions are not "inhibition or inactivation of tyrosinase" from being formed into melanin (as conventional synthetic skin-whitening agents does & acts as a tyrosinase inactivating agent) but in PWS action - melanin is completely formed with less color or colorless, as natural melanin solvents like compounds are naturally enhanced within the skin and acts as thinner of these melanin pigment(s). More to this, Gluthathione found in ordinary Pearl can be absorbed only thru the oral ingestion and can’t be absorbed thru the skin, the bioactive concentration of gluthathione reaching the skin for to be any functionality is very negligible (experimental trials of pure biologically soluble gluthathione is directly absorbed thru the skin to where it is required to function in the most appropriate bioavailability is simply a novelty unique to PWS, but this is not the only case of PWS Skin-whitening effect, as the bioavailability soluble Bezoar Acid has a few separate functionality in the whitening regime of the skin. PWS's Bezoar acid stereoisomers- D-Bezoar acid &L-Bezoar acid, and the racemic mixture of DL-Bezoar acid had shown a strong skin-whitening effect and these PWS Bezoar acid derivatives are also further acts to enhanced the unsaturated fatty acids (USAF) with 12 -22 carbon chains found in the lipids of the skin cells to acts a skin- whitener as well (within epidermis level); while the functionality of these USAF are increased actions as "lipid moisture retainer - formed as a fatty film" at the surface layer of the epidermis. PWS's Bezoar acid's uniqueness is that of one of its derivative which acts similar to magnesium salts of Ascorbic acid’s - 3-phosphate acts (4) as an antioxidant stabilizer to the whitening effect actions (inhibits the browning again of the PWS whitened skin and mimic of the Vitamin C's regenerative actions to various stages in the cell-metabolism, including removing the accumulated cellulite and toxins in the cellular region to transported via the fatty acids to be broken down in the liver during the

Campo Pearl Extract


conversion to Glycogen (animal starch), and discharged from the body thru the normal excretory means. There is an UV-A&B absorbance action further to be credited to the presence of Bezoar acid derivatives on the skin, which principal methodology of efficacy is out of context for this paper, as the above said implication "Mimic of Vitamin C esters by the PWS's Bezoar acid esters" as it (vitamin C) is not synthesis by mammals i.e.; human body) and as it is known that Bezoar Acid (from Bezoar Gail-stone/Nui Huang) and its esters can be produced by human body,; will required a full paper to elaborate the mechanism. This whole concept of understanding the PWS SKIN WHITENING-EFFECT has to be elaborated in the manner as discussed above, as there are more fifteen different actions and pathways spontaneously taking place when skin has absorbed PWS, which elaboration and discussions will be too lengthy with the nature of minute and esoterically complex mechanism(s) being taking and hypothesizes as such, involved etc, to be any other-wise manner of explanation in this summarized paper. As we have clearly defined else where that the PWS was a spin-off cosmetic ingredient that was reached Drug-Candidate status for Human Clinical Phase I for Anti-Melanoma and other types of Skin-Cancers, before being scrapped due to technical difficult of filing and in obtaining a full patent protection from generic drug manufacturers who simply can deliberate and copy in parameters of PWS production and its very excellent drug efficacy by various other scientific means in short possible time.

Campo Pearl Extract


LITERATURE REFERENCES: 1) ROBERTS, D.F.,J. COS.COSMET.CHEM,, 1977,28 329 2) G PROTA, RECENT ADVANCES IN THE CHEMISTRY OF MELANIN

GENSIS IN MAMMAL, J. INVEST., DERMATOL, 75, (1) 16-18, 1982 3) PERSONNAL COMM DR M BALASUBRAMANIAM, KAMPOYAKI JAPAN

MELANOMA DRUG INVEST PROJECT, 1988 - 1992 4) TAKASHIMA, ET AL., AM.PERFUM., COSMET, 1971, 86(7), 29

Campo Pearl Extract


Tyrosine-Melanin reduction enzyme (s) Which convert melanin in to Leuco-Melanin*

Tyosine-Melanin reduction enzymes which are responsible for the catalyst & formation of Leuco-melanin are isolated, stabilized and

optimized; and are optimized bio-available from the following natural products-cosmetic functional active extracts for new novel

range of skin-whitening personal-care products:

Campo Snow White Coral Algae Extract

Campo Pearl Extract Pws

Campo Pearl Bezoar Acid Extract-pbaws

* Campo Pearl Powder Extract

* Campo Pearl Organic Germanium Extract-pogws * Campo Ginseng Organic Germanium Extract * Campo Garlic Organic Germanium Extract

Campo Songyic Acid Complex

Campo Songyi Gel Liquid 25% (Matsutake-Kuseki) * Campo Songyi Ethanol Fraction Extract and Campo Bird’s Nest Extract

*Leuco-melanin, a colorless, invisible melanin which is functional as

photo-protection without darken skin pigment

Novel Structure of a Leuco-Melanin reduction catalyst Enzyme (S) as found in

our Campo Novel-Skin-Whitening Actives.

Campo Pearl Extract


DISCLAIMER : The information contained herein is accurate to the best knowledge and belief of Campo Research Pte Ltd, and specification quoted may change without prior notice. Information contained in this technical literature is believed to be accurate and is offered in good faith for the benefit of the customer. The company,Campo Research Pte Ltd, however, cannot assume any liabilities or risks involved in the use of its natural products or their derivatives or raw materials or ingredients, since the conditions of use are beyond Campo Research Pte Ltd’ s control. Statements concerning the possible use are not intended as recommendations to use our materials in the infringement of any patents or infringements of mandatory regulatory requirements or without any safety evaluations conducted when used in combination with materials of other suppliers.. We make no warranty of any kind, expressed or implied, other than that the material conforms to the applicable standard specifications. Campo Research Pte Ltd accepts no liabilities of whatsoever either expressed or as otherwise arising out of the information supplied, the application, adaptation or processing of the products described herein, or the use of other materials in lieu of the Campo materials or the use of Campo raw materials or ingredients in conjunction with any other products and raw materials. The use of Campo Research Pte Ltd's raw materials or ingredients in any formulations are to be compulsory tested and to be assayed for safety and toxicology profiles evaluations and according the mandatory regulations as required by the laws and regulations of the countries where the evaluation and use of Campo Research Pte Ltd's raw materials or ingredients has been formulated as single components in any carrier systems or as in multi-components formularies. The end-users, marketers; manufacturers, formulation laboratories or importers of Campo Research Pte Ltd' raw materials and ingredients which are incorporated into any formularies as formulated or re-sold or re-exported or assayed in accordance with any mandatory regulatory requirements of any country or infringement of any patents assume all liabilities as that may arise out of the use of Campo Research Pte Ltd's raw materials and ingredients in any formularies in combination with raw materials and ingredients of other suppliers or as single components in any carriers. The definition of users as mentioned in these instances are manufacturers, marketers, formulation laboratories, consultants, and importers assumed all liabilities arising as either personal injuries suits, infringements of patents suits, infringements of or failures to meet regulatory requirements suits of a formulary either as single components in any carrier systems or in as multi-components formularies in which are may consist of a Campo Research Pte Ltd's raw material or ingredients.

IMPORTANT NOTICE Specifications may change without prior notice. Information contained in this technical literature is believed to be accurate and is offered in good faith for the benefit of the customer. The company, however, cannot assume any liability or risk involved in the use of its natural products or their derivatives, since the conditions of use are beyond our control. Statements concerning the possible use are not intended as recommendations to use our products in the infringement of any patent. We make no warranty of any kind; expressed or implied, other than that the material conforms to the applicable standard specifications.

campo pearl extract€¦ · japanese cosmetic house, for its natural uv white, a uv protection,...

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