calyx bio-ventures corporate presentation

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……………………………………………………………………………………………………… TSX-V: CYX | Corporate Presentation May 2013 Renewable Energy Founded in Agriculture

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Calyx Bio-Ventures Inc. trades on the TSX Venture Exchange under the symbol "CYX" and owns a majority position in Agrisoma Biosciences Inc. Agrisoma is an agricultural biotechnology company that uses a proprietary Engineered Trait Loci (ETL) technology licensed from Calyx to commercialize a suite of industry-leading oil quality and crop improvement traits for use in energy feedstock crops. For further information about Calyx, its technology, collaborations and partnerships, please visit www.calyxbio.com. Resonance™ is a trademark of Agrisoma Biosciences Inc. For more information about Resonance, visit www.agrisoma.com.

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Page 1: Calyx Bio-Ventures Corporate Presentation

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TSX-V: CYX | Corporate Presentation

May 2013

Renewable Energy Founded in Agriculture

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Forward  Looking  Statements  

Certain   statements   contained   in   this   document   constitute   “forward   looking   statements”.   When  used   in   this   document,   the  words   “may”,   “would”,   “could”,   “will”,   “intend”,   “plan”,   “propose”,  “anticipate”,  “believe”,  “forecast”,  “estimate”,  “expect”  and  similar  expressions  as  they  relate  to  the   Company   or   its   management,   are   intended   to   identify   forward-­‐looking   statements.   Such  statements   reflect   the  Company’s   current   views  with   respect   to   future  events   and  are   subject   to  certain  risks,  uncertainties  and  assumptions.  Many  factors  could  cause  the  Company’s  actual  results,  performance   or   achievements   to   be  materially   different   from   any   future   results,   performance   or  achievements   that  may  be  expressed  or   implied  by  such   forward-­‐looking  statements.  Given   these  risks  and  uncertainties,  readers  are  cautioned  not  to  place  undue  reliance  on  such  forward-­‐looking  statements.  The  Company  does  not  intend,  and  does  not  assume  any  obligation,  to  update  any  such  factors  or  to  publicly  announce  the  result  of  any  revisions  to  any  of  the  forward  looking  statements  contained  herein  to  reflect  future  results,  events  or  developments  except  as  required  by  law.  

2 www.calyxbio.com

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We’re  all  about  

•  leveraging  our  IP  to  improve  crop  yield  &  performance  

•  the  first  crop  “Resonance-­‐carinanta”  can  …  

•  reduce  the  world’s  petroleum  dependence  and  greenhouse  gas  emissions  associated  with  transportation  fuels  by  creating  a  …  

•  drop-­‐in,  cost  competitive  alternative  to  petroleum-­‐derived  fuels,  compatible  with  existing  engines  yet  with  superior  performance.  

3 www.calyxbio.com

a  scalable  seed  business  

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4 www.calyxbio.com

 

Carbon  Dioxide  Emissions:    •  Flying  accounts  for  a  large  portion  

of  emissions  

•  There  is  currently  no  large  scale  production  of  alternative  energy  for  air  travel  

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•  Calyx  owns  a  proprietary  portfolio  of  patents  with  respect  to  modifying  and  engineering  agricultural  crop  traits  

•  Technologies  have  been  licensed  to  Agrisoma  Biosciences  Inc.,  a  majority-­‐owned  subsidiary,  which  is  applying  these  technologies  primarily  to  a  new  oilseed  crop  called  “Resonance®”,  a  variety  of  brassica  carinata  

•  Resonance  carinata  produces  oil  that  is  superior  for  industrial  applications,  such  as  biofuel  production,  than  are  food-­‐based  oils  like  soy  or  canola  

•  Resonance  carinata  grows  more  oil  per  acre  than  other  oilseed  feedstocks  on  target  lands  

•  Agrisoma  is  a  seed  technology  company  that  sells  Resonance  carinata  seed  to  farmers.    2012  was  the  commercial  launch  of  Resonance  carinata  seed  sales  

5 www.calyxbio.com

Renewable  Energy  Rooted  in  Technology  

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Carinata  Uses  

100%  of  the  Resonance  carinanta  crop  is  used  and  produces  two  products:  oil  &  meal  

OIL    -­‐  CAN  BE  REFINED  INTO  •  drop-­‐in  jet  fuel  •  biodiesel  •  other:  naptha,  emulsifiers  

MEAL  •             animal  feed  that  is  high  in  soluble  protein  •             approved  for  sale  in  the  United  States  as                cattle  feed  

6  www.calyxbio.com

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Why  Resonance?  

•  multi-­‐billion  gallon  demand  for  renewable  oil  feedstock  for  biodiesel  and  biojet  fuel  from  non-­‐food  sources    

•  aviation  is  an  industry  that  has  committed  itself  to  zero  carbon  growth  through  biojet  fuel  usage,  creating  huge  demand  

•  Resonance  carinata  offers  a  hugely  scalable  opportunity  to  profitably  produce  high-­‐quality  renewable  oil  at  a  price  point  superior  to  other  feedstocks  

•  Resonance  carinata  is  suited  to  semi-­‐arid  lands  and  crop  rotations  and  can  be  scaled  to  multi-­‐millions  of  acres  of  production  without  displacing  food  crops  

•  Resonance  carinata  utilizes  existing  infrastructure  throughout  the                              farm  to  the  end-­‐user  

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Resonance  carinata  –  ideal  for  brown  soil  zones  

16  million  acres  

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Resonance  carinata  =  oil  +  meal  

•  sustainable  production  on  semi-­‐arid,  marginal  lands  

•  40M+  acres  of  lands  suitable  for  Resonance  in  just  North  America  

•  ideal  rotation  crop  -­‐  no  displacement  or  competition  with  food  crops  

•  Resonance  carinata  entered  first  commercial  year  in  2012  –  successfully  harvested  6,000+  acres  at  all  growing  sites  

•  meal  approved  for  sale  as  cattle  feed  in  the  USA  

9 9  www.calyxbio.com

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growers  have  fallow  lands  

Crop  Ramp-­‐Up  ü  2011  -­‐            50  acres  ü  2012  -­‐  6,049  acres      Ø  significant  grower  demand  

for  product  

Ø  excellent  performance  in  drought  conditions  

Ø  scalable  business  opportunity  into  key  US  markets  

Ø  in  excess  of  40  million  acres  of  production  capacity  in  North  America  alone  

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Market  development  through  field  tours  and  trade  show  promotion  with  target  growers  

www.calyxbio.com

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grower  marketing  &  support:  Crop  Walk  Series  (summer  2012)    

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•  farmer  focused,  field  walks  of  production  sites    •  opportunity  to  meet  with  producers  and  see  real  world  results  •  total  2012  summer  Crop  Walk  Series  reached  500  growers  across  AB  &  SK  

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Carinata’s  competitive  advantage:  more  yield  per  acre  on  target  lands  

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a  distant  cousin  of  Canola,  yet:    

•  higher  heat  tolerance  

•  more  resistant  to  drought  

www.calyxbio.com

Resonance-­‐carinata  

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Global Demand for Energy Crop Feedstock

2006 % of total production

2012 % of total production

Oilseeds 6% 25%

Palm oil 3% 21%

Wheat / barley 1% 2%

Corn 7% 15%

Sugarcane 17% 28%

Source : Rabobank analysis

2006 2012

Ethanol 11 B gal 27 B gal

Biodiesel 2 B gal 8.9 B gal

Total 13 B gal 35.9 B gal

Biofuel Demand Biofuel Feedstock Source

Ø  according  to  the  International  Energy  Agency,  or  IEA,  biofuel  production  could  reach  approximately  112B  gallons  by  2030.  To  meet  these  targets,  the  IEA  believes  feedstock  production  would  need  to  increase  to  150M  acres  in  2030,  up  from  75M  acres  in  2010.  

Ø  oilseeds  are  the  fastest  growing  feedstock  source  –  biodiesel  and  aviation  

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Source : Cere’s S-1

www.calyxbio.com

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Dedicated Feedstock Crops Enable The Biofuels Value Chain

•  Feedstock Oil Quality & Cost

•  Production on Farm – Scalability, Infrastructure

•  Crop Processing and Delivery of Oil

•  Biofuel –Manufacturing Efficiencies

long  chain  oils  –  uniform  chemistry  for  manufacturing  efficiencies  -­‐  lower  cost  than  food  oils  being  used  now      easily  scaled  to  large  acreage  -­‐  Crop  production  infrastructure  in  place,  including  strong  agronomic  package  –  growers  engaged    and  committed  to  Carinata  production      standard  oilseed  processing  with  valuable  meal  co-­‐product,  uses  current  infrastructure      long  chain  oils  =  most  efficient  feedstock  for  conversion  technologies  –  less  waste,  more  fuel,  better  quality  fuel    

Value  Chain  -­‐  Needs                                  Resonance  Carinata  Energy  Feedstock  Solution  

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competitive  edge  for  Resonance  carinata  

•  high  concentration  of  Erucic  acid  (22:1)  

•  two  jet  fuel  molecules  (C8-­‐C14)  from  one  C22  fatty  acid  whereas  C18  oils  can  only  produce  one  jet  fuel  molecule  

•  higher  yields  of  jet  fuel  and  better  cost  structure  

•  higher  probability  of  optimal  cracking  and  diversity  of  carbon  chains  

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resonance-­‐carinata  biojet  exceeds  ASTM  specs  

HRJ Renewable Green Jet™

Agrisoma RediJet Carbon Distribution

Resonance Biojet Analysis1 Match to ASTM Specifications2 Manufacturer3

16 www.calyxbio.com

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April  2012:  Porter  Airlines  Flight  

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•  on   April   17,   2012   Porter   Airlines  conducted   Canada's   first   bio-­‐fuel  powered  revenue  flight    

•  porter   airlines   flew   one   of   its  Bombardier   Q400   turboprops  from   its   base   at   Billy   Bishop  Toronto   City   Airport   to   Ottawa  using  a  50/50  blend  of  biofuel  and  Jet   A1   fuel   in   one   of   its   engines.  The   fuel  was   certified   to   the  new  American   Society   for   Testing   and  Materials   (ASTM)   D7566/D1655  standard  and  the  biofuel  used  was  derived   from   oilseed   crops  including   the     Resonance   oilseed  grown  and  produced  by  Agrisoma.  

www.calyxbio.com

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April  2012:  NRC  National  Research  Council  

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•  biojet  fuel  refined  from  Resonance-­‐Carinata  blended  50/50  with  petroleum-­‐based  jet  fuel  for  NRC  flight  

•  real-­‐time,  in-­‐flight  emissions  testing  conducted  by  trailing  jet  using  a  “sniffer  probe”  

“particulate emissions, including aerosols of black carbon, sulphates and by-products of the combustion of aromatic compounds, are significantly lower”

In-flight trailing emissions testing in six independent flight segments using Honeywell Green Jet Fuel™ including above the 50/50 blend ratio1

1As reported by the National Research Council Aerospace at the Farnborough Airshow July 9, 2012

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October  2012:  a  world  first  !  civilian  jet  aircraft  powered  by  100%  biofuel  

19 www.calyxbio.com

NRC  flew  a  Falcon  20  jet  powered  100%  by  biojet  fuel  refined  from  Resonance-­‐carinata.        This  flight  was  the  first  time  in  the  world  a  civilian  jet  aircraft  was  powered  by  100%,  un-­‐blended,  renewable  jet  fuel  that  met  petroleum  jet  fuel  specifications      

Results  of  Flight:  •  no  engine  modifications  were  required  

•  50%  reduction  in  aerosol  emissions  

•  25%  reduction  in  particles  

•  49%  reduction  in  black  carbon  

•  improvement  of  1.5%  in  fuel  consumption  

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December  2012:  Popular  Science  

20 www.calyxbio.com

Popular  Science  Magazine  declared  the  100%  biofuel  flight  as    

“one  of  the  year's  25  most  important    scientific  events”  

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Next  Steps:  North  American  Expansion,  Extensive  Testing  Program  

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•  northern  production  zone  

•  50  trials,  27  locations  

•  nursery  sites  established:  

•  Swift  Current,  Saskatchewan  

•  Minot,  North  Dakota,  SDSU  

•  winter  crop  development  in  the  south:  

•  Successful  testing  in  Mississippi  

valley  and  Southeast  (Univ  Florida)  

•  North  America  production  potential  

exceeds  40MM  acres  without  impacting  

food  production  

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Continued  Development:  ETL  technology  

•  our  ETL  technology  is  a  proprietary,  field-­‐validated  crop  improvement  platform  that  creates  enhanced  crops  

•  the  platform  is  able  to  efficiently  introduce  or  stack  multiple  traits  simultaneously  into  engineered  plant  chromosomes  

•  the  ability  to  introduce  all  of  these  traits  in  one  cycle  is  far  superior  to  current  trait  introduction  methods  that  require  multiple  cycles  

•  ETL  will  significantly  increase  the  amount  of  oil  per  acre  yielded  and  further  enhance  the  superior  economics  of  Resonance-­‐carinata  

•  ETL  technology  viability  supported  by  licensing  agreement  with  Dow  Agrosciences,  which  has  licensed  ETL  for  use  in  food  crops  

22 www.calyxbio.com

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Continuous  Improvement:  breeding  &  trait  stacking  

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•  Breeding:  

•  largest  Brassica  Carinata  collection  in  the  world,  over  1,000  accessions  

•  hybrid  development,  extensive  testing  program  with  over  >50  trials,  winter  and  

summer  nurseries  

•  molecular  markers,  haploidy,  hybrids,  genome  sequencing,  advanced  breeding  

tools    

•  Traits:  

•  unique  trait  stacking  ability:  proven  chromosome  engineering  technology  

(Engineered  Trait  Loci  -­‐  ETL)  

•  extensive  trait  collection  related  to  oil  and  yield  

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Business  Milestones  

ü Initial  commercial  rollout  –  6,000  acres  seeded  and  harvested  in  2012    

ü secured  strategic  partnership  with  PGF  Biofuels  for  logistics,  handling  &  commercial  contracting  in  North  America  &  Australia  

ü commercial  test  flights  

ü acquired  majority  ownership  of  Agrisoma  Biosciences  Inc.  

ü Introduced  higher  yielding  line  of  Resonance  carinata  in  2013  q  secure  off-­‐take  agreements  

q  biojet  fuel  production  underway  

q  Certification  of  carinata  under  Renewable  Fuel  Standard  in  USA  

q  meal  approval  in  Canada  

q  continue  trials  in  USA  in  advance  of  commercialization  

q  continue  field  trials  of  ETL  Carinata  to  achieve  commercial  status  by  2015  

 

24 www.calyxbio.com

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Why  Calyx?  

ü  timing:  16  years  of  science  and  $20  million  of  aggregate  investment  -­‐  commercial  product  now  ready  

ü management  track  record  of  building  companies  and  delivering  returns  to  shareholders  

ü proprietary  technologies:  Calyx  owns  master  license  for  “ETL”  chromosome  technology  and  Agrisoma  owns  the  breeder  rights  for  Carinata  

ü 2012  saw  first  significant  seed  sales  and  crop/revenue  growth  –  6,000+  acres  planted  

ü great  crop  performance  on-­‐farm  in  spite  of  2012’s  severe  drought  conditions  in  much  of  North  America  

ü huge  market  for  oilseed  feedstock  –  currently  a  feedstock  shortage  exists  globally  including  North  America  –  strong  demand  means  farmers  will  quickly  adopt  Carinata  

ü Carinata  provides  feedstock  better  suited  to  fuel  and  industrial  uses  than  other  feedstocks,  thereby  enabling  biofuel  production  to  be  more  economic  –  sustainable  competitive  advantage  

25 www.calyxbio.com

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Calyx  Bio-­‐Ventures  capital  structure    

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Calyx  Bio-­‐Ventures  Inc.  (CYX-­‐T)  capital  structure  

common  shares  issued  &  outstanding:    29.8  million  

fully  diluted:          39.3  million  

recent  price:          $0.27  

market  capitalization:                                                                    ~$8  million  

v  Closed  on  $4.0M  in  December  2012  @  $0.30/unit  with  a  ½  warrant  (1-­‐year)  at  $0.60                                      

www.calyxbio.com

Calyx’s  ownership:          50.0%  

BDC  Venture  Capital’s  ownership:      49.9%  

Others:                  0.1%  

v  Each  party  responsible  for  pro-­‐rata  portion  of  Agrisoma  funding  

 

Agrisoma  Biosciences  Inc.,  capital  structure  

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Calyx Bio-Ventures Management

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Wm. Hugh Notman, President & CEO •  Partner at Stirling Mercantile Corporation, corporate

finance advisory •  Corporate director of public and private companies

Richard Whittall, Director •  CEO Newstrike Capital Inc. ($300M Market Cap) •  Corporate director of several public and private

companies •  Former Director of Burcon Nutrascience Kevin Rathbun CFA, Corporate Development •  Former CFO of Realm Energy (bought out in 2011) •  Director of Newstrike Capital Inc.

Keir Reynolds, Investor Relations •  President of Mammoth Market Advisory Corp. •  Raised in excess of $120M in public venture capital

Stuart MacGregor, Director •  President of MacGregor Equities Inc., a Toronto

based manager of an investment partnership with a focus on private equity investments; previously, a Partner of Polar Capital Corporation

David T Howard, Director •  Previously a director of JRI International Ltd., a

privately-owned agriculture company and SemBioSys Genetics, Inc., an ag-biotech company

Louis P Lacasse, Director •  President of GeneChem Management Inc.,

manager of a specialized biotechnology venture fund

www.calyxbio.com

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Agrisoma - Management Team

•  Steven Fabijanski, PhD President & CEO •  20+ years senior executive experience in the agriculture and biotechnology industry,

previously built and sold a seed company specializing in oilseed technology (Sold to Pioneer)

•  Patrick Crampton, MBA VP Business Development •  15+ years global marketing and product management for Syngenta Seeds

•  Michael Lindenbaum, PhD VP Technology •  15+ years R & D, inventor, as well as the scientific and technical leader of the ETL

technology applications

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Supported by management and advisors with decades of agricultural business experience: • Daryl Males – Agrisoma Product Manager (previously product development manager at Viterra Inc.)

• Mejda Lortie – Director of Government & Regulatory Affairs (previously government affairs leader at Biotech Canada)

www.calyxbio.com

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Calyx Bio-Ventures Inc. (TSXV:CYX) www.calyxbio.com

Hugh Notman President & CEO T: (604) 689-2495

[email protected]

Keir Reynolds Investor Relations T: (778) 998-9242

[email protected]

Kevin Rathbun Corporate Development

T: (604) 837-4360 [email protected]