california tumor tissue registryheterogeneous right adrenal mass with calcification and central...

CALIFORNIA TUMOR TISSUE REGISTRY

"Endocrine Pathology"

Study Cases, Subscription A

November 2006

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Loma Linda University School of Medicine 11021 Campus Avenue, AH 335 Loma Linda, Calltornla 92350

(909) 558-4788 FAX: (909) 558-(1188

E-mail: [email protected]

I'ID'f

2

Target audience: Ptacticing pathologists aod pathology residents.

Goal: To acquaint the participant with the' histologic features of a variety of benign alid

mal.ignant ntQpla.'<IIIS and tumor-like conditions:

Objectives: The participant will be able to retQgnize morphologic features of a variety of benign

and malignant neoplasms and tumor-like cOnditions and relate those processes to pertinentreferenoes in the medical literature.

Edutational method• and media: Review of represenlative glass slides with associated histories. Feedback on consensus diagnoses from participating pathologists. Listing of selected refe-rences from the medical literature.

Priocinal faculty: Donald R. Chase, MD

CME Cred.it: Lorna Linda University School of Medicine designates·this continuing medical

education activity for up to 2 houn; of Category I of the Physician' s· Recognition Award of the American Medical Association.

CME credit is offered for the subscription year only.

Acereditatioo: Lorna Linda University School of Medicine is accredited by the Aceredilation

Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians.

Study Cases, November 2006, Subscription A

Contributor: Lorna Linda Pathology Group (mm) Lorna Linda, CA

Tissue from: Adrenal glands

Clinical Abstract:

Case No. 1 - November 2006 A

Accession #29173

A 42 year old man had worsening symptoms of Cushing's syndrome. A full work-up showed no localized masses. A bilateral adrenalectomy was performed.

Gross Pathology: The left adrenal specimen weighed 27 grams and contained a 7.0 x 4.5 x 2.0 em adrenal gland

with a slightly nodular, dark red cortex and a red-tao medulla. The right adrenal gland specimen weighed 32 grams and contained a 6.5 x 3.2 x 2.5 ~m adrenal gland with a slightly nodular purple-tan cortex.

Contributor: Xuedong Wang, M.D. Case No. 2 - November 2006 A Pasadena, CA

Tissue from: Adrenal gland Accession #29472

Clinical Abstract: Multiple medical problems developed in this 33 year old woman during the late stages of her

pregnancy. She was admitted at 36 weeks' gestation because of fetal demise. During work-up, a mass was noted in her right adrenal gland and very high norepinephrine levels were found.

Gross Pathology: The 120 gram, 7.5 x 6.5 x 4.8 em adrenal gland was largely replaced by a yellow-gray mass

with areas of necrosis.

Study Cases, November 2006, Subscription A 3

Contributor: Loma Linda Pathology Group (mrd) Loma Linda, CA

Tissue from: Right adrenal gland

Clinical Abstra.ct:

Case No.3 - November 2006 A

Aecession #29239

A pregnant 21 year old woman was discovered to have elevated serum and urine cortisol levels. A mass was found in her right adrenal gland.

Gross Pathology: The specimen consisted of a I 08 gram, 7.0 x 6.0 x 4.5 em, well-circumscribed orange-colored

mass.

Contributor: Lester Thompson, M.D. Case No. 4 - November 2006 A Woodland Hills, CA

Tissue from: Left adrenal gland Accession #30274

Clinical Abstract: A 63 year old woman had a history of hypertension, which recently had become postural. She

presented to the emergency department with epistaxis. During work-up she became diaphoretic and complained of chest pain. A CT scan showed a left adrenal mass.

Gross Pathology: The resected mass was 2 em in diameter and had a yellow-red cut surface with areas of

degeneration and hemorrhage.

4 Study Cases, November 2006, Subscription A

Contributor: Loma LiDda Pathology Group (bl) Loma LiDda, CA

Tissue from: Thyroid

Clinical Abstract:


Accession #29237

While pregnant, this 30 year old woman was noted to have a thyroid mass. A needle aspiration biopsy was negative and the mass was watched for two years until it increased in size. At that time, a subtotal thyroidectomy was perfonned.

Gross Pathology: The left lobe of the thyroid was replaced by a 4.9 x 3.4 x 2.5 em friable red-tan mass.

Contributor: Phillip Gordon, M.D. Case No. 6 - November 2006 A Winter Haven, FL

Tissue from: Thyroid Accession #30193

Clinical Abstract: A 35 year old woman presented with a fullness in the left side of her neck. A thyroidectomy

was performed.

Gross Pathology: The left lobe was 8.4 grams and 3.5 x 3 x 1.3 em.

Srudy Cases, November 2006, Subscription A s

Contributor: Robert James, M.D. Case No. 7 - November 2006 A Ventu.ra, CA


Clinical Abstract: This 60 year old woman had a goiter and cervicallympliadenopathy. A total thyroidectomy

was performed. After surgery, her blood calcitonin level was 1550pglmL (reference range for females, post-calcium stimulation: 35 pglmL or less).

Gross Pathology: The markedly irregular thyroid gland had a 9 x 5 x 5 em right lobe and a4.5 x 2 x 2 em left

lobe. The right lobe contained an 8.5 em diametc:r rubbery, pale tan tumor.

Contri"utor: Scott Silveira, M.D. Case No. 8 - November 2006 A Dearbom,MI


Clinical Abstract: For three years, this 38 year old woman had been known ro have a .right sided thyroid nodule

and for one year she had been on medication for hypothyroidism. After symptoms of recurrent laryngeal nerve involvement we.re noted, she underwent aright h.emithyroidectomy.

Gross Pathology: The 56 gram, 7.0 x 4.5 x 3.0 em thyroid lobe was replaced by a firrn, homogeneous pale yellow

tumor.

Special Studies: AEI/AE3: TTF-1: Thyroglobulin:

6

positive positive negative

Study Cases, November 2006, Subscrip1:ion A

Contributor: Lorna Linda Pathology Group (mp) Lorna Linda, CA

Tissue from: Adrenal

Clinical Abstract:


Accession 1#30619

Angiography showed this 52 year old woman to have a thrombus involving her inferior vena cava and extending into her right hepatic vein. Additional radiographic findings included a heterogeneous right adrenal mass with calcification and central necrosis.

Gross Pathology: The 1,168 gram specimen included the right lobe of the liver with an attached 12.0 x 11.5 x 9.0

em well-circumscribed gray-tan mass. The heterogeneous cut surface consisted of multiple pink, yellow and gray-tan nodules up to 3 em in diameter, with areas of residual yellow adrenal cortex. There were large areas of necrosis.

Special Studies: Positive: ]llegative:

Synaptophysin, calretinin EMA, S-100, HMB-45

Contributor: Peter Morris, M.D. Santa Barbara, CA

T~ue from: Thyroid

Clinical Abstract:

Case No. tO - November 2006 A

Accession #30389

After a 6-month course of treatment for thyroiditis, this 18 year old woman was referred for thyroidectomy because of the presence of three thyroid nodules.

Gross Pathology: The right lobe of thyroid weighed 64 grams and was 6.5 x 6 x 3.3 em. The cut surfaces showed

innumerable pale tan-white nodules ranging from 0.3 to 2.5 em in greatest diameter. There were no areas of calcification, hemorrhage or cystic degeneration.

Special Studies: Abnormal cells negative: Abnormal cells negative, with

positive staining of background lymphocytes:

Abnorm.-tl cells positive:

Study Cases, November 2006, Subscription A

TIF-1, AE1/AE3, CAM5.2, CK8, CD45

CD3, CD43, CD20 CDJO

7

CALIFORNIA TUMOR T ISSUE REGISTRY

ENDOCRINE PATHOLOGY

Minutes- Subscription A

November, 2006

SUGGESTED READING (General Topics from Recent Literature):

Pediatric Salivary Gland Malignancies. Shapiro N Land Bhattacharyya N ., Otolaryngol NaM Neck Surg 2006; 134:63 I -634.

Implications oflntratubular Seminoma. Berney OM, Lee A, et at. Hum Patlto/2006; 37:458-461. Higb.(irade Pelvic Urothclial Carcinoma of the Renal Pelvis. Clinicopathologic Study of 108 cases With Emphasis 011

Unusual Morphologic Variants. Perez-Montiel 0, Wakely PB JR, et al. Mod Patho/2006; 19:494-503. Special Stains for Upper Gl Biopsies Not That Helpful. Wright Cl and Kelly JK. Am J Surg Patho/2006; 30:357-361. Ovarian Krukenberg Tumors. K.Jyokawa T, YoUIIg RH, Scully RE, et at. Am JSurg Palho/2006; 30:277-299.

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: [email protected] Web site & Case of the Month: www.cttr.org

FILE DIAGNOSES

(Preferably submitted on website at www.cttr.org. Click "subscriptions", then submit answers".)

CTTR Subscription A

Case 1: .

Case2:

Case3:

Case4.:

CaseS:

Case6:

Adrenal cortical ~yperplasia, nodular T-93000, M-83700

Phe~hromocytoma, adrenal gland T-930QO, M-87000

Adrenal cortical adenoma T-93000, M-81400

Pheochromocytoma, adrenal T-93000, M-87000

Papillary carcinoma, thyroid T-96200, M-80503

Tall cell/columnar papillary carcinoma, thyroid T-96000, M-45810

Case 7:

CaseS:

Medullary carci.noma, thyroid T -96000, M-851 03

November, 2006

Sclerosing mucoepidermoid carcinoma with eo~inophilia, thyroid T-96000, M-84303

ca.~_ejl;

Adrenal cortical carcinoma T,93 100, M-83703

Case 10: Nodular sclerosing Hodgkin's lymphoma, thyroid

T-96100, M-96563

Case No. I, Accession No. 29173 November 2006

~ - Adrenal cortical hyperplasia, nodular Bt!dwin PJrk (Kaiser Pqmanente) - Adteoal conical hyperplasia (4) Chico - Nodular adrenal cortical hyperplasia l,a Jolla IScrjovs ·Hcallhl - Adrenal cortical hyperplasia with atypia Lone Beach - Adrenal cortical hyperplasia (S) Mooterey ICommunjlY Hospital oflhc Monterey Peni!l!l!lol - Acquired hyperplasia Qllis.!l!l!!! - Adrenal hyperplasia Ommre (]{ajser Pe!maocnlel - Multinodular adrenal cortical hyperplasia Ognoe <O!JD•• County Medical Gmuo) - Adrenal cortical hyperplasia Onngc CUCI Medical Centa:l - Cortical hyperplasia Oxnard 1St. John's Rcojonal Medical Center) -Adrenal cortical hyperplasia Sacrnmcnto IUC Davjs Resjdent<l • Primary pigmented nodular adrenocortical disease Son Dieoo IUCSDl - Diffuse adrenocortical hyperplasia Sonia Barl!ara - Adrenal cortical byperpt.sia SIQ!a Roy - Nodular adrenal hyperplasia (J) Woo!!lan!l Hills ISuda's Soldiers\ - Adrenal cortical hyperplasia (pituitary, ectatle) (I); Adrenal cortical hyperplasia ( I ) Arkansas (!Jnjvcrsily of Arkansas Cor Medical Scjepces) - Adrenocortical nodular hyperplasia, adrenal Florida. AmerjQ3!h - Adtcoal hc:monbage florida IJacbon Memorial Hospjtn!l - Adrenal gland hyperplasia floric!a /Munroe Re•ionul Medical Center) - Micrunodular hyperplasia Florida ITa!l&hassce Po!bology As:socjatesl - Adrenal conical hyperplasia f!orida<W'mtq Haven Hospilall - Adn:oocortical hyperplasia Georgia IWcllgar KennC$!one Hospjlall - Primary pigmented nodular adenocortical disease Illinois IM!l&Ncal Memorial Hospjl!l!\ - Cortical nodule/adenoma ( l ); Adrenal cortical hyperplasia (Cushing syndrome) ( I) Illinois £Heartland Rcojona! Medical Coo!erl - Adrenul cortical hyperplasia lm!iana (HoW!I!'d Regjopa! Medical Center! - Adrenocortical hyperplasia M•swhwcns !Berlcsbln: Medical Center) - Bilateral adrenal hyperplasia M•'W•usetts !Tufts. New England Medical Center Resjdenls) - Pigmented nodular hypcrpii!Sia Michigan !O!!kwood Ho:;pjtaJ) • Adrenal hyperplasia (I); Diffuse hyperplasia ( I) lleb!asb <Ctd@ton !Jnjvmirtl - Adrenal conical hyperplasia New York CNgssau Uniymity Medical CenwrJ - Nodular cortical hyperplasio, adrenal, functional New York !SUNX Stony Brook! - Cortical adrenal hyperplasia North CaroUna (Mounlajo Area Pathology! - Adrenal cortical hyperplasia (1); Nodular hyperplasia (2) PmnsyMoja !Conemau&h Memorial Medical Center! - Adrcttal hyperpt.sia Pennsylyanla (Lehigh Valley Hosoitoll - Diffuse cortical hyperplasia Pcnnsylvnnjn <Magee Women's liospitall - Adrcnocortienl hyperplasia J>ennsylyanja (ML Nj!tAny Medical Center! - Macronodular adrenal hyperplasia with hypercortisolism Pamsylyonjo CPcnnsylnnia Hospj!AI Residents) - Adrenal hyperplasia Texas (The Melhodist HO§l1itall - Adrenocortical hyperplasia Texas. HoUSJoo - Nodular adrenocortical hyperplasia Icm l..ubb9ck - Nodular bype<plasia We!! Yiroinja (Greenbrier Valley Medical Center> - Adrenal nodular hyperplasia West Virginjo /Wetzel Coyoty tlospjtall - Cortical hyperplasia Conada IPosoua Hospital! - Cortical hyperplasia Clnada !Shcrbruoke llnjycrsity HQSpjtaJl - Nodular hyperplasia of the adrenal gland Gcnnanv llpstitut fur Paihologie UKEJ - Adrenal conical hyperplasia !long Kong (Pamela Youde Nethersole Eastern Hosoitall - Adrenal cortical hyperplasia O.w !Hamad Medjcol Corpornllon\ - Adrenal cortical hyperplasia Saudi Arabja £King l'ahot! Natlooa! Guard Hospilllll - Adrenal hyperplasia The Ncthcdands, Ams!elvcen - Adrenal cortical hyperplasia United Kin8dom IOxfor!l Study Gmuol - Adrenal diffuse cortical hyperplasia

Case I - Diagnosis: Adrenal cortical hyperplasia, nodular

T-93000, M-83700 Directors nott: "'The process also shows focal pigmentation in a minority oCihc slides." drc.

ClTR. November 2006 "Minutes" (Sub$<ription 1\) J

Case l - References: Kohler 0. Anding K, nnd Bohm N. Primary Pigmented Nodular Adrenocortical Dy.plasia. Pathol, ReseOJ'cl~ & Practice 1998;

194(3):201-204. Wu HH, Cramer HM, Kho J, eta!. Fine Needle Aspiration Cytology ofBenigo Adrenal Cortical Nodules. A Compllrision of

Cytologic F'mdings with Those of Primary nnd Metastatic Adrenal Maligoaneies. Acta Cytologlca 1998; 42(6): 1352-1358. Endo Hand Olea T. Jwcta-Adrmal COrtical Cell Ne:m or Nodular Fonnali011 in the Younger Oencralion- \YIIat Does It Mean?

l'athol, Research & Practice 1998; 194(11):765-772. Tcrzolo M, Boccuzzi A, Ali A, et at. Cushing's Syndrome Due to ACTH-lndcpende<~t Bilateral Adrenooortlcnl Maeronodular

Hyperplasia. J of Endocrine lnvost l991; 20(5):270-275. Jalali M and Krishnamunhy $. COmparision oflmmunomarkers for the Identification of Adrenooorlical Cells in Cytology

Specimens. Diog Cytopatlu>l2005; 33(2):78-82.

Case No. 2, Accession No. 29472

Alameda - Pheochroonocyloma Baldwin PorldKaiser l' crmaneptel • Phcochromocytoma(4) Olico - Pheochromocytoma La Jolla !Scripps Health) - Pheochromocytoma Lon• Beach - Pheochromocytoma (5) Monterey <Community HospitaJ.oflhe Monterey pcnjnsu1al - Phoochromocytomu l2l!k!!Ylll - Pheochromocytoma Qrange (){•i:ter Pqmancntcl - Pheochrotoocytoma Onmoe CQrangc COunty Medical GroUP) - Pheochromocytoma Orange CUC! Medical Center\ - Pheochromocytoma Oxnanj !St. John's Regional Medical Center! - Pheochromocytoma (2) Sacramento IUC Davjs Residen!Sl - Pheochromocytoma San Djego I!!CSDl - Pheochromocytoma Santa l!arbata - Pheochromocytoma Santa Rosa - PheochromocytOma (3) Woodland l·lills ISuda's Soldiers\ - Pheochromocytoma (2) Arkansas (University of Arkansas for Medical Scjcnces\ - Phcochromocytomn. adrenal Florida. Amqjpath - Medullary hyperplasia Florida !Jackson Mem9ria] Hosnitall - Pheochromocytoma Florida (Munroe Rcgjonal Medical Center\ - Pheochromocytoma flortdaffi!!ahassce Pathology Assocjn!es) - Pheochmmocytomn Florida CWintcr ffayen Uospital\ - Pheochromocytoma Gcomia IWclls!ar Kenncstono Hospila!\ - Pheochromocytoma Illinois !MacNeal Memorial Hospitatl - Pheochromocytoma (2) Illinois CHc!lCl!and Rcaion!!l Medical Center\ - Pheochromocytoma Indian• (1-!oward Regjona] Medical Center) - Phoochromoeytoma Massachusetts CBcrksttjre Medical Center) - Phoocbromocytoma M!I.<S!Gbuset!S fTuiW-Ncw Ens land Medical Center Residents\ • Pheochromocytoma MichjRI!J C<la!;wooc! Hospital\ - PheochromocytOma (2) Nebruka CCreishton Unjyec;ityl - Pheochromocytoma New York <Nassau linjyersity MediCAl Center! - Pheochromocytoma New York CSUNY Stony Brookl - l'hcoehromocytoma No!!h Carolina(MounWo Area Pathology) • Pheochromocytoma (3) Pennsylyania !Conemaugh Memorial Me!ljca! Center) • Pbeochromocytoma Pennsylyania CLehigh Valley Hospital> - Pheochromocytoma Pcoosylynnja (Magee Women's Bosnilall - Phoochromocytoma Pennsylyania IML Njuany Medical Center> - PheochromOcytoma, adrenal gland Pennsylvania (Peposvlyania Hospi!Al R.,;dentsl - l'hoochromocytoma Texas Obe Methodist HQSI)i!all • Pheochromocytoma Iexa'!, Houston • Pheochromocytoma Texa.<. Lubbock - Phcochromocytomn West Vjr2jnia (Gn;enbder Valley Mcdjeal Center\ - Pheochromocytoma West Vjminia CWet:t.el Counw HospHall - Pheochromocytoma C4Mda CJ>a.wua RospjWl - Pheochromocytoma Can&da CShcrbrookc Uojvcr.;ity Hospilal\ - Pheochromocytoma

November 2006

4 CTTR. Noven>ber 2006 .;Minulfs" (Subscription A)

GC!l!13!lv !ln5titut fur Pi,tbologie UK!ll - Pheochromocytoma Hong Kons (paroela YoydeNethcrsolc Epm H9!fpilal) - Pheochromocytoma Oatar (Hamad Medjcal ComoratiQO) - l'bcochromoeytoma Saudi Ar!bia !King Fabod National Oyard Rosnitall - Pheochromocytoma The Netbq!apds. Amsldyeen - Pheochromocytoma of the adrenal gland United Kinadom COxford Study Grpuo> - Adrenal pheochromocytoma

Cas• 2- Dlunosis: Pheochromocytoma, adrenal gland

T-93000, M-87000

Case 2 - References: Plouin PF and Gimeocz-Roqueplo AP. The Genetic Basis of PbcochromoeytomL Who to Sa= and How? Nat Clln Pract

Endocrlnol Metab 2006; 2(2):60-61 . Orodski S, lung C, Kertes P, ol al. PhMOchromocytoma in PregnWJcy. lnttm Med 12006; 36(9):604-606. Ouller U, Turck J, EubiiJlkS S, et al. Detecting Pheochromocytoma. D<fining tho Most Sensitive Test A 1m Surg 2006; 243(1 ): I 02-

107. Dahia PL. lfao K, Rogus J. et al. Novd Phcochromocytoma Susceptibility l..oci ldenlif"Jed by lottgJativc Geoomies. Omcor Ru

2005; 6$(21):9651-9658. -llanda U Kbullar U and Mohon H. Pigmeoted PhcocbromocytomtL Report of a case with Diagnosis by Fine Needle Aspiration.

Acta C)!to/2005; 49(4):421-423.

Case No. 3, Accession No. 29239 November 2006

A]ameda - Adrenal cortJcnl neoplasm !)aldwin Park CKaiser Pcnnanentel - Cortical adenoma (adrennl) (4) lJlli;!! - Adrenal cortical adeoolllll !.a Jolla CScrioos Heal!hl - Adrenal eortical neoplasm, tavor adenoma Long Jleach - Adrcoal cortical adenoma (5) Monterey <Community HoSJ>ital of the Monterey Peojnsulal - Adrenal cortical carcinoma (2); Adrenocortical adenoma (2) ~ - Cortical adenoma Orange !K ajyr Pcrmanentcl - Ad~ conical adenoma Orange <Orange County Medical Groypl - Adrenal cortical adenoma Omnge IUC! Medical Center! - Cortical adenoma Oxnard 1St lobo's Reclooa! Medical Center! -Adrenal cortical adenoma Saqamq]IO 0/C Dayjs Resjdcn!>l - Cortical adenoma San Diego IUCSOl - Adrenocortical adenoma Santa BarbllrJl - Adrenal cortical adenoma Santa Rosa - Invasive adenoma of adrenal gland ( I); Adrenal cortical adenoma (2) Woo<lland Hms ISuda's Soldiers) - Adrenal cortical adenoma (2) 1\rbosa;; IUnivqsity ofAd<llllS8S for M<dical Scicru;esl - Adrcoocortical adenoma, adrenal florida. Amsripath - Adn:oal adenoma flori<fa !Jackson Memorjal Hospi!8Jl - Adrenal cortical adenoma f lorida <Munroe Regionnl Medical Ceoterl - Cortical adenoma florida !Tallahassee Pathology Asroc!arcsl - Adrenal adenoma florida CWjntcr Haveo HO!!pitaD - Adrenocortical adenoma Georgia IWei!S!¥ Kenocsrone HospiJu!) - Cortical adenoma !!Unois <MacNeal Memorial liosni!8)) - Cortical adenoma (2) !llloois <Heart]and Reajonal Mediql Center! - Adrenal cortical neoplasm, favor adenoma !ndiaoa <Hol!l!!d RcgipoaJ Medical Ceo]&rl - Adrenal cortical adenoma MB.'-<aCbUSC!JS merkshire Medical CCQ!tC) - Adrenocortical adenoma MIISSachugr[S Crufts-New England Medical Cen!er Residents\ - Adrenal cortical adenoma Michiaan COakwooc! HosojlaJ\ - Adrenal cortical adenoma (2) Nebra<b <Creishton Unjvrnjlyl - Adrenal cortical adeooma New Yodc !Nassau Univenity Medical Center) - Cortical adenoma New York ISl/NY Siony Orookl - Cortical adrcnnl ndenoma North Carolina (Mount4in Area Pathology! - Adrenal cortical neoplasm (3) Peonsv!I'Mja CConernaugh Memorial Medical Ccn!crl - Adrenal corticaladcooma

Cri'R, November 2006 "Mintrtc:s• (Subscription A} 5

Pcnnsvlynnja (Lehigh Valley Hospjtall • Cortical adenoma vs. foeal nodular hyperplasia Pmnsylvaoja (Magee Women's Hospjta!l • Adcnocortical adenoma Pcnnsvlunia(Mt. Ninaoy Mec!ical Center) • Adlenoeortical adenoma Pennsylvania CPennsyhaoia HospjJal Rqidcotsl • Adreoal adenoma Tgn Obe Mdbsxlist Hospital) ... Adrenocortical adenoma Texas. Houston - Adrenal adenoma IexM. Lubbock - Cortical adenoma \Vc:o.1 yjrajoia <Greenbrier Valley MedjcAI Center) .. Adrenal cortical adenoma West Virginia CWetzel County Hosnltnll - Cortical adenoma Cann!la ll'osgua Hosoi!all - Cortic.~l adenoma Can!!da ISberbmoke University Ho:mjtall • Adenoma (fascicular bone) GennMv Clnstitut fur Patholooic !JKEl - Adrenal cortical adenoma Hona Kons CParnola Youde Nethersole Eascm H<»yital\ - Adncnal eorticnladcnoma Oatar fHama4 Medical Cnrponuionl • Adrenal cortical adenoma Sauc!j Ambia CKin2 Fahad NatiOMI Guard Hosnita!l • Adncnal cortical adenoma The N!:thcrl8!!ds. Amstelyeq! - Adrenal cortical adenoma United Kjnsdom <Oxford Study Group) • Adrenal cortical adenoma

Co•e 3- Diagnosis: Adrenal cortical adenoma

T·93000, M-81400

Case 3 - References: Ghorab Z, lorda M, Ganjei P, et al. Melan A (A103) is Expressed in Adrenocortical Neoplasms But Not In Renal Cell and

Hepatocellular Carcinomas. Appllmmunohisto & Molecular Morpho/2003: 11(4 ):330.333. Zhllllg Pl, Gcncga EM. Tomaszewski JE, ct al. The RoleofCalretinin, lnhibio. Melan-A. BSL-2 and C-Kit in Oilfereotialing

Adrenal Cortical and MeduUary Tumors. An lmmunobiSIOCbemical Study. 2003; Modern Potho/2003; 16(6):591-597. Sasano H, Suzuki T and Moriya T. Oiseeming Malignancy in Resected Adrenoeortical Neoplasms. Endocrlnt Potho/2001;

12(4):397-406. Stojadinovic A, Brennan MF, Hoos A, ct al. Adrenocortical Adenoma and Carcinoma Histopathological and Molecular

Comparative Analysis. Modern Patho/2003; 16(8):742-751. Erickson LA, Lloyd RV, Hartman R, et al. Cystic Adrenal Neoplasms. Canctr· 2004; 101(7):1537·1544.


Alamq!a - Pheochromocytoma Baldwjn Pad< (Kaiser Penmancntcl • Cortical adenoma (adrenal) (4) QUsQ - PheochromocytOma La Jolla CScnoos Health! - Pheochromocytoma !.ono Qeach - Malignant pheoehromoeytoma {S) Montqey CCommunitv Hospital of the MontereY Peninsula) .. Pheochromocytoma Q.Qkl.crul - Adrenal carcinoma Ornnso O<aiscr Pcrmancntel - Phe<>chromoeytoma Omnoe IOcange County Medical Group) • Pheoehromoeytoma Orange CUCI Medical Cenrerl - Pheochromocytoma Oxnard ISL John's Regional Medical Center> - PheocbromoeytOma {2) Slmmen!O fUC Davis Residco!S) • Pheochromocytoma San Ojqo ruq;m - Pheochromocytoma Santa Bltbara - Pbeoehromocytoma Sontn RoS!l • Pheochromocytoma (3) W90dland Hms CSuda' s Soldiers) - Pheochromocytoma (2) ArkanS!I.:i fUnivcrsity of Arkansas lb r Medical Sciences! - Pheochromocytoma. adrenal florida Amerinath • Pheochromocytoma Florjda (Jackson Memorial Hosi2W!!} • Phcoehromocytoma Florida (Munroe Regional Medical Ccmer) • Nodular adrenal medullruy hyperplasia Floddg Cipllahassee-Pathology Assocjatesl - Pheochromocytoma floric!a C\Vintcr Haven Hosoita!) - Phcoehromocytoma Gco!!!i& !WeiiS!l!r Kenncstonc RospjtaD • Pboochromocytoma

November 2006

Illinois (MacNeal Memorial HosnitaD • Neuroeodocrineturnor(l): Adrenal cortical adenoma (Conn's syndrome){!)

6 C1TR. Novm>ber 2006 "Minutes" (SUbscription A)

Illinois <Heartland Regiopal Meciical Center) - Pheochromocytoma lndiw <Howard RegjonaJ Medical Center> - Phc:ocbromocytoma ~!Jnarhysens CBcrkshin; Medjcal Center> • Pheochromocytoma M'""thusctts ITyfts..N;w England Medjcal Csntg Residents> - PheochromocytOma Micbhll!!! CQakwood Hospila!l - PheochromOCytoma (2) Nebraska !Crei•hton Up!yersitvl - Pheochromocyll>ma New York <Nassau llniyc[$jty Medical <&otcr> - Pheochromocytoma New York <SUNY Stony Brook! - Pheochromocytoma Nonh Carolina !Moun!Ajn Area Patl!o!ogy) - Phcochromocytoma (3) Pennsylyanja !Conqnau!!h Memorial Medical Center> - PheochromocytOma PenosvlvBI!i•IUbi•h valley Hosnitall - Phc:ocbromocytoma Pcnnsylyanja CMagee Women's Hospital) .. Pheochromocytoma l'ennsylvani• CMtNitww Medical Center! - Pheochromocytoma, adrenal gland Pennsylvania <Pennsvlyonio HospicaJ Residents) - Pheochromocytoma Tex;s !The Mcthodistliospilall - Pheochromocytoma Tg'$ HoUSion ... Phcoehromocyt.oma Tem Lubl!ock - Phcochromoc:ytoma West virginia fGreenbri<t Valley Medical Ccoterl - Phc:ocbromocytoma West Yirgjnia I'Wctzel County 1-Jospitall .. Phcochromocytoml\ CBOada CPasoua HOSTJjlol\ - Pheochromocytoma Canoda ISherbrooke University Hosoitall - Pheochromocytoma Gqmuw (lnstiM fur PaJhologie UKEl - Pheochro!OOC)1oma HOQ8 Kong CPamc;la Youde Ne!lte!1!01e Eastern Hospi1all - Phcochromocytoma Ol!lr !Hamad Medical C0!!!0!1!!ionl - Phcochromocytoma Saudi Arabi• <King Fabad National Guard Hospital> - Phc:ochromoeyll>ma The Ncthedands Amstolycco - Adrenal pheocbromoeyll>ma l)nlied Kingdom !Oxford Study Grougl - Adrenal pheochromocytoma

Case 4 - Diagn0$is: Pheochromocytoma. adrenal

T-93000, M-87000

Case 4 - References: Din<.~ BK. Franks ME, Bebarl A, et al. Pl!rlinl Adrenalectomy. Tite National Cancer lnstiMe 13xperience. Uro/2005: 66(1):19-23. A marL, Servais A, Gimcncz.-Roqueplo AP, et Ill. Year of Diagnosis, Featurts nt Presentation, and Risk oi'Recurreocc in Patients

with Pbc:ocbromocytoma or Sc:crelins, l'4f18Ntglioma. J Clin Endocrinol Me tab 2005; 90( 4 ):21 1 0.2116. Elder E£. Elder G and l..aiSSOO C. Pbeoc:bromocytoma and Functional Paraganglioma Syndrome.. No longer the 10% Tumor. J Sutg

Oocvi200S; 89(3):193-201. Naya X, Ichikawa T, Su~lci H, ctal. Efficocy and Sa!c:ty of Laparoscnpic Surgery for Pheochromocytoma. lnt J Uro/2005;

12(2):128-133. Westphal SA. Diagnosis of a Pbeocbromoeytoma. Am J Med Sc/2005; 329(1 ): tS-21.

Case No. S, Accession No. 29237 November 2006

~ - PaplUary th)'l'Oid careinoma Ba!dwjn l)ark(J(Wser Pemmnentcl .. Papillary cnrcinoma (4) ~ - Papillary thyroid careinoma 4 JO)Ia (Scripps Heahbl - Papillary thyroid carcinoma Lon& Jls!T - Papillary carcinoma of !be thyn>id (S) Monterey !Community Hosnjta! of the Mommy Peninsula) - Papillary thyn>id can:inoma !l!ildlll.!l - Papillary careinoma Omoac CKniser Pennnnenjel ~ Papillary t.hyroid carcinoma OrMae f'Or;mge County Medical Group) - Pepillary carcinoma Or!noe fUCl Me<lica! Center) - Papillary lh)'l'Oid carcinoma Oxnard (SL John's BcsionaJ Medical Center! -Papillary ca:einoma ofthy.oid (2) SacrJmq!to CUC Davjs Resick:ntsl - Papillll)' can:innma of !he lhyn>id San Ojcgo CUCSDl - Well-<liff"""'tiated papillll)' thyn>id carcinoma SantaBarbara - Papillary carcinoma Santa Rosa - Papillary carcinoma of!hyroid (3)

C'ITR. Novanber2006 "Minutes" (Subscripcion A) 7

Wondi!U!d Hl!ls CSuda's Soldiers) - Papillllt)' thyroid carcinomo (2) • Ar1uy!sM OJnh•er.;itv of Arkanw for Mcdjcal Sciences> - Papillary thyroid c.arcinoma, thyroid florida. Amcrioa!h - Papillary thyroid carcinoma Florida CIA£ls!!!n Memorial Hospjlllll - ~illary thyroid carcinoma Florida (Muome Regional Medical Center\ - Papillary careinoma flori4a ITa!labessee Pa!hology Ass9cja!C$) - Papillary carcinoma ofll>e thyroid Florida CWjntcr Ha~n Hospital) - Papillary can:inoma Georgia CWcllstar Kennestonc Hospjloll - PapUJruy thyroid can:inoma ll!jnois (MacNeal Memorial Hosoitall • Papillary carcinoma, thyroid l!ljoojs CHeartland Re&ional Medical Ccpterl - Papillary carcinoma !ndjana <Howard Reeional Medical Center! - Papillary careiooma, thyr<>id Ma:!S!!Cbusctts £Berkshire Medical Center! - Papillary carcinoma Massachusetts ITufts-New Enoland Medjcal Center Residents) • Papillary carcinoma, thyroid Michjgan !O!!lswoo<i Hosnilllll - Papillary carcinoma (2) Nebmk& !Crcigllton Uojversityl - Papillary thyroid carcinoma New Xort <Nassau Univqsitv Medical Ccntql • Papillary thyroid careinoma New York !SUNY Stony Brook) - ~illary thyroid can:inoma, panly sclctotie North Carolina CMoontam Area Pa!holo1rtl - Papillary thyroid carcinoma (3) Pennsylyania <Conemaugh Memorial Medical Center> - Papillary can:inona ofth)Toid J'eonsvlynni• <Lchieb Valley Hospital> - Papillary careinoroa Pcnnsylyania <Mngee Women's Howitol> .. Papillary carcinoma Pennsyll'lllli• !ML Njttany Medical (;eOJ'!) • Papillary careinoma, thyroid g!Wld f>coosyJya.nia CPennsvlvap'ja Hosnjtnl Rgsjdcots) · Papillary carcinoma Texas CThe Methodist Hosnitall - Papillary thyroid carcinoma Texas Houston - Papillary thyroid carcinoma Tex..,. Lubbocls - Papillary carcinoma of thyroid Wcs Virginia C<Jrecnbrier Valley M<dlcal Center! - Adenocarcinoma, papillary WCSJ Yirgjnja (Wetzel County Hospjta!l • Papillary carcinoma Canada CPasoua HQS'!illlll - Papillary cateinoma and Hashimoto's disease Canada CShabrookc Univqsjty Hospjtall - ~illary carcinoma Gennanx Onstil1lt fur Pathologjc UKID - Papillary tarcinoma Hons Kons <Pamela Youde Nethersole Eastern Hospital) • Papillary ean:inoma ofth~Toid O!!W fHamad Medical Comorationl - Papillary thyroid carcinoma Saudj Arubia CKing faha!l National Guard tlospjl!!ll - Papillary thyroid carcinoma '!be Ntthcdwu!s. Amslclvccn - Papillary thyroid carcinoma Unl!ed Kjnodom (Oxford Study Groyp) - Thyroid papillary can:inoma

Case 5 - Diagnosis: Papillary C3l'Cinoma, thyroid

T-96200, M-80503

Case S - References: Mehmood RK, Basha SJ and Ghan:eb E. A Case of Papillary Careinoma Arising in Ectopic Thyroid Ttssu<: within a Branchial Cyst

with Neck Node Metastasis. Ear Nos• Thr«U J 2006; 85(10):675-676. Haas SN. Management ofl'apillary Microcarclnoma of the Thyroid. SD Med 2006; 59(10}:425-427. Wang Z, Qiu S, Eltork)' MA, et al. HlslUpathologic and Immunohistochemical Characterization of a Prinuory Pupillary Thyroid

Carcinoma in tbe Lateral Cervical Lymph Node. &p Mol Patho/2006. Collin! P Moltavelli F. Pellegrinelli A, Cl a!. Papillary Carcinoma of the Tioyroid Glllltd of Childhood and Adolescence.

Morphologic Subtypes, Biologic Behavior and Prognosis. A Clinieopathologic Study of 42 Sporwlic Cases Treated at a Single Institution During a 3().Ycar Period. Am J Surg Padwl '1006; 30(11):142().1426.

Oionigi G. Dionigi R, Banalena L. 01 a!. Surgery of Lymph Nodes In Papillary Thyroid cancer. E:sper Rtrv AlllfCQJKW Tiler 2006; 6(9): 1217-1229.

Case No. 6, Accession No. 30193 November 2006

AlamedA - Papillary thyroid eareinoma, IIIII cell variant Ba!dwjo J>art <Kaiser Pcrmanentel - Papillary careinoma ("tall cell" variant) (4)

8

~ - Columnar cell corcinoma (columnar wriant of papillary carcinoma) l.alolla CScrinns Health) - Papillary thyroid carcinoma, columnar cell variant l,ong Beach - Papillary carcinoma, tall cell variant (~) Mootgey <eommunity Hosnital of the Monterey Penigsulal - Papillary lh)TOid careinoma, tall cell variant (2); Folticular adenoma

(I); Columnar cell c:arcinoma {I) ~-Adenoma

Omgge CKojsq PennansDJc\ - Papillary thyroid carcinoma, !All-cell variant Oragge !Orange County Medical Group) - Tall cell variant of papillary carcinoma Oranoe !tiC! Medical Cemcrl - Papillary thyroid, columnar variant Oxnard !St. J9hn's Reojognl Medicn! Center) ·Papillary carcinoma, tall cell variant (I); follicular adenoma vs. tall cell variant (I) Saaa!nento OJC Davis Residents) • Tall cell carcinoma of tile thyroid s.o Diego cucsm - Papillary thyroid carcinoma. columnar cell variant Santa Barbnra • Thyroid hypetpl"-'ia &mta Rosn - Papillary carcinoma of tull cell variant (2); Papillary thyroid CArcinoma, cncopsulated ( I) Woodland Hills CSuda's Soldjers) - Papillary carcinoma, columnar wriant (2) M!n:s!:; CUgjversity of Arlsansas for Mc;dical Scicnc:csl - Papillary thyroid carcinoma. tall cell wri11111, tb)TOid florida. Ameripatb • Tall cell papillary carcinoma • florida Oaclsson MemoriAl HospjtaJl · Columnar variant or papillary thyroid carcinoma florida <Munroe Rcgion!!l Medical Center> - Papillary carcinoma, taU cell variant FJorida iD!!eh•ssce Palhg!ogy AS5"QA1§l - Papilla.ycartinomaofthe thyroid Florida !Winter Haven HospjtaD - Columnar variant papillary cnrcinoma Georgia !Well:.w Kenneslone HOMil!!!\ - Papillary thyroid carcinoma, columnar variant Illinois !MacNeal Memorial Hosnilall- Papillary carcinoma, thyroid (I); Thyroid papillary carcinoma, tall cell wriant {I) Jlljnois !Heartland Regional Medical Center) - Follicular adenoma with papillary areas Indiana fHownrd Regional Medlen! Cco1cr\ - Tall cell varian~ papillary thyroid carcinoma Massachusens<Berkshire Mcdjcal Center\ - Papillary carcinoma, variant tall cell Mossl!fhusetq qufts..New En&lan<l Mc!lical Center Residents\ - Papillary c:arcinoma, colwnnar type thyroid/medullary carcinoma Miehi!!l!!l. !Qnkwood Homjta!\ - Papillary carcinoma, tall cell variant (2) Nebraska !Crejsh.ton linjycr!jiM - Papillary thyroid carcino!IUI, tall/columnar cell variant New Vorl: lN•ssm University Medical Center) • Papillary thyroid carcinoma, columnar-tall cell type

New York ISVNY Stony Brook) - Tall cell wrian~ papillary thyroid carcinoma North Carolina (Mountain Area Patholosyl - Papillary thyroid carcinoma (2); Papillary thyroid carcinoma, tall cell type (I} Pennsylyanla !Conemaugh Memorial M¢jcal Center) - Papillary carcinoma of thyroid, columnar variant Pc:on.wlvanjp Q&bigh ¥alley HOSDitAl) - Papillary carcinoma. call ceU variant hnnsvlvan!a fM...,., WOroeo's Hospila!> • Papillary carcinoma, taU cell wriant Pcogsytvanjn !Mt. Njttany Medical Center\ • Columnar cell carcinoma (a variant of papillary carcinoma), thyroid gland Pennsylvanja CPennsyiYAAja HospitAl Residents) .. Columnar cell cw-cinomn Texas !The Mctboc!iS! Ho:mital\ - Papillary tllyroid carcinoma (columnar cell variant) TCI!!t< Ho\Lll()n - Follicular adenoma with papillary hyperplasia Texas. Lubbock - l'apillury carcinoma, tall cell variant We:.1 Virginia !Greenbrier v alley Mcdjcal Center) - Follicular varinnt of papillary carcinoma West Y'trgjnja (Wetz<:l Counsv HOS!!ilall - Papillary carcinoma Canada !Pasqua Hosoi!l!)\ · Papillary carcinoma, columnar cell type Canada IShc;rbrogke tlnjycrsitv Homilnl\ - Papillary carcinoma, lall cell variant Geananv Onsthut fur Pathologic \IKEl ·· Papillary carcinoma, columnar cell variant Hong Kong IPan!ela YoudeNctbenlole East<m HospjtaD - Papillaryca..:inomaoftbyroicl. tall cell wriant Oa!ar !Hamgd Mc!lical Cgrponuionl - Columnar cell varian~ papillary carcinoma Saudi Arabia CKing Fahad National Gu8!!l HQMitall • Papillary thyroid carcinoma The Nethedands. Amstelvecn - Columnar cell carcinoma of the thyroid United Kin&dom !Oxford Study Gmuol - Thyroid, tall cell wriant papillary con:inoma, lymphocytic thyroiditis

CITR, November 2006 .. Minutes" (Subscription A) 9

Case 6- Diagnosis: Tall celVcolumnar papillary carcinoma, thyroid

T-96000, M-45810

Case 6 • References: Euscbi v. Damiani S, Ellis 10, et al. Breast Tumor Resembling lhe Tall Cell Varillllt of Papillary Thyroid Carcinoma. Report of5

Cases. AmJ Surg Pathol2003; 27(8):1 114-1118. Gupta S. SodhMi P, Join S, e< at. Morphologic Spectrum of Papillary Carcinoma of the Th)'I'Oid. Rok of Cytology in IdentifYing the

Variants. Acta Cyto/2004; 48(6):79$-800. Yiagan LR, Dehner LP, Huettner PC, et al. Columnar Cell Variant of Papillary Thyroid Carcinoma. Report of a Case with Cytologic

Findings. Acta Cyto/2004; 48(1):73-77. Solomon A, Gupta PK, LiVolsi VA, ct at. Distinguishing Tall Cell Variant ofl'apillwy Thryoid Carcinoma from Usual Variant of

PapiUarylbyroid Carcinoma in Cytologic Specimens. Diagn Cytopatlw/; 2002; 27(3):143-148. Nair M, Kapita K. Karole AK, ct at. Papillary Carcinoma of the 'Thyroid and its Variants. A Cytohistologieal Correlation. Diagn

Cytopolho/2001; 24(3):167-173.


Alameda - Medullary carcinoma Baldwin Parle fKaiscr Pcrmllllcntcl • Medullary carcinoma ( 4) ~ • Medullary carcinoma Lil Jolla CScrjpps Hcalthl - Medullary thyroid carcinoma !.cmg Beacll - Medullary carcinoma (S) Monterey{Communjty Hosoital oftheMonterev Peninsula) • Medullary carcinoma Oakland - Medullary carcinoma Osanoe CK•iw Pqmansntcl - Medullary carcinoma Qrungc {Or!!llae County Medical Grounl • Medullary CftrCinoma Omnge OJCI Medjcnl Centerl • Medullary carcinoma Oxn!l!'d CSl John's Regional Medical Center\ - Medullary carcinoma (2) Sacramento C!JC P!lyjs Residents) - Medullary carcinoma San Diego (UCSQl • Medullary carci.noma Santa Barbara • Carcinoma Santa Ro5a • Medullwy carcinoma (3) Wooslland Hills CSuda's So!diml • Medullary carcinoma (2) Ar!sansas OJniveaitv ofA!kansa< for Mc!lical ScjenMl - Medullary carcinoma, thyroid florida: Ameripath - Medullary carcinoma florida <Jackson Memorial Hosoitall • Medullary carcinoma, poorly differentiated florida <Munroe RegjonaJ MedjcaJ Center - Medullary weinoma florida <Ta)!aha•m Pathology AsSQCjprul - Medullary carcinoma of the thyroid florida (Winter Hayen Rosoitall - Medullary carcinoma Georgia (Wcllstar Krope:Ftone Ho.mitall - Medu.JJary eercinoma lllinojs <MacNeal Memorial Hospj(Ail - Medullary carcinoma, thyroid (2) Illinois CHcartland &•ional Medical Center) • Medullary car~:inoma Indiana CHownrd Rcajnnal Medical CcnJer) • Medullary carcinoma Massachusetts <DcrkShjl'f Mes!ica! Center) - Medullary carcinoma Massacbusens Cl\lfls-New England Medical Center Residents> • Medullary earclno.ma, thyroid Miobi21lll <Otlswoo<l Hosoitall - Medullary carcinoma, squamous variant (I): Medullary carcinoma ( I) Nebraska <Ctcig!JJoo 1/nivqsityl - Medullwy carcinoma New York <Na'S'" Universirv Medigl Center) - Medullary carcinoma New York CSVNY Stony Brook) • Medullary carcinoma. thyroid J'!orth Carolina CMoyntain Area l'niholoay) - Medullary thyroid carcinoma (3) Pennsylvania CConcroaugh Memorial Medical Center) • Medullary carcinoma of thyroid PennsyiVllllia ().e!Jish Valley Hosoital) - Medullary carcinoma PennsviYl!Di• <Magoe Women's Hospj(Ail - Medullary carcinoma Pcnnsvlvaoia (ML J'!jttany Medical Cguql • Medullary carcinoma, tb)'I'Oid gland Pennsyl·vania CPennsylyania Hospital Rgjdentsl - Medullary carcinoma Texa< <The Methodjs! HospiJII!l - Medullary thyroid carcinoma Texas Houston • Medullary thyroid carcinoma Tex!L'l Lubbock • Medullary carcinoma

November 2006

10 CTTR, Novcmba 2006 "Mim!!es" (SUI»<riptioo A)

WCSJ virginia IG!CC!lbricr Valley Medjsa! Center) - Medullaty can:inolllll West yjrgjnia QVetzeJ Coyntv HosnjtBU - Medullary carci.noma Canoda !Pasqua Ho1ohal\ - Medullary carcinoma Cana!la (Shcrbrookc Unjvcrsitv Hosojtall • Medullary CIIJ'Cinoma f1!2!Jl!!Av Onstitut fur Patholosie UKEl • Medullary can:inoma Hooa Kong <Pamela Youdc Ne!herljole Eastern Hospital\ · Medullary c:on:inoma of thyroid O.W Oianmd Medical Co!!lO!ll!ionl - Medullaty carcinoma S.1udj Arabja <Kino faha4 National Guard Hospital\ • Me<lullary carcinoma The Netherlands. AmS)clvccn · Medullary carcinoma of the thyroid Unite<! Kingdom IOxfqrd Study Grounl - Thyroid. medullary carcinonlO

Case 7- Diagnosis: Medullary carcinoma, thyroid

T ·96000, M -85 I 03

Ca.w 7 · References: Bockbom M. Sheu SY, Frilling A. ct al. ParagangJioma-LikeMedullaty 'lluyoid Carcinoma. A Rare Entity. Thyroid 200S;

IS(I2):1363-1367. Brauckhoff M, Lon:nz K, Ukkat J, ct al. Medullary Thyroid Carcinoma. Scandin J o[SW'g 2004; 93(4):249-260. KhuranA R, Agarwal A, Bajpai VK, ct al. Unraveling the Amyloid ll.1$ocinted with Human Medullary Thyroid Carcinoma.

l.':ndocrino/2004; 14S( 12):5465-S470. Ensinger C, Prommegger R, Kcndlcr D, et al. Hcr2JNcu Expression inC-Cell Hyperplasia and Medullary Thyroid Carcinomas.

Alllicczncer ~ 2003; 23(38):2241·2243. Tlbmi H. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type2. Endocrine Patho/2003; 14(2):123-131.

Cast: No. 8, Accession No. 29543 November 2006

6lilmedJ! • Sclerosing mucoepidermoid carcinoma with eosinophilia Bllldwjn Park (Kajser Pennanentel • Poorly-diffe<enliated carcinoma (2); Poorly difTi:rontiated carcinoma with squamous features

(2) ~ - Sclerosing mucoepidermoid carcinoma with eosinophilia !,a Jolla (Sqipos Heal(hl • Sclerosing mucoepidermoid carcinoma with eosinophilia loos Beach - Metastatic poorly difTerentialfd squamous cell carcinoma, lung primary (S) Mootcrev CCommonjty Hosoi!J!! of the Montmv Pcnjruulal - Anaplestie carcinoma (2): Sclerosing mucoepidermoid carcinoma

with eosinophilia (2) ~ .. Neuroendocrine vs. insular carcinoma O!JnRC CKN:;er PcanMcnlel • Mucocpidennoid carcinoma Oranoe lOran•• COuntY Medical Omupl • Lymphocytic thyroiditis Omnse IUC£ Medical Centfrl • Poorly differentiated squamous cell carcinoma OxnAI!! CSL John's Rcsional Me<lica! Center) · Sclerosing mucoepidermoid carcinoma with eosinophilia (2) SI!Cramcnto (UC Dayls Residents) • Metastatic squamous cell carcinoma of lung SM Djego CUCSDl - Sclausiog mucoepidermoid thyroid carcinoma with eosinophilic San!l B8rl!am • Carcinoma Santa Rosa • Mucoepidermoid carcinoma wilh eosinophilia associated with Hashimoto tllyroiditis (2); Sclerosing mucoepidermoid

carcinoma with eosinophilic (I) WOO<!Innd Hills ISudfs Soldiers) • Mucoepidermoid carcinoma with eosinophilia (2) ArkJlll!!;M CUnivcr.sitv ofArtansa~ for McdicaJ Sciences> - SeJerosing muoocpi9ennoid carc.inoma with cosi_nophilia, thyruid florida, A!l!CriQ!!lh • Squamous carcinoma Floric!aiJackson Memorial Hosnitall • Squamous mucoepidermoid carcinoma witll eosinophilia arising in liashimoto's thyroiditis P!oric!a (Munroe Reajonal Medical Center! • Papillary carcinoma, sclerosing variant florida ITallahas;oee Pa!holosv Ass!leiatcsl • Medullary carcinoma of the thyroid Florida CWintcr Hayen Hosnitall • Sclerosing mucoopidennoid carcinoma Goorgjo IWcllstar KepneS)One HD>pj\a!l • PTCA witll squamous diffCJ<:ntintion ll!joojs <MacNeal Memorial H2S!!itall - Mucoepidermoid carcinoma. thyroid (I); Muooepidcrmal carcinoma. rule out metastatic

carcinoma (I) ll!inojs CHean!and R£Ci9!la! Medical Ccntql • Sclerosing mucoepidermoid carcinoma with eosinophilia lndi:w. <Howan! Bcajonal Medical Center) • Mucoepidcnnoid c:on:inoma M!I$$!1Chusetts ffi,>cksbjre Medical Center\ - Sclcrosina mucoepidermoid carcinoma with eosinophilia Mj1S3!1Chusetts ITuO&:New llns!and Mc4jca! Center Rcsjd<'D!Sl • Sclt:ro$ing mucpepidcrmoid carcinoma with cosinophiliu

crrR, November 2006 "MinlltOS" (Subocription A) II

Mjehigan (Oakwood Hospital! - Sclerosing mucoepidermoid carcinoma with eosinophilia (2) Nebraska CCrejghton llniversity) · Hashimoto•s thyroiditis with squamous metaplasia vs. pure squamous cell carcinoma New York CNassau University Medical Center) • Mueoepithelioma New York CSUNY Stony Brook) - Muooepidermoid carcinoma with eosinophilia North Carolina (Mountain Area Pathology\ • Muoocpidennoid carcinoma, sclerosing variwll (2); Muooepidennoid carcinoma (I) Pennsvlvania (Conemaugh Memorial Me<lica! Center) • Sclerosing mucoepidermoid tumo1 of thyroid Pennsylvania (Lehigh Valley Hosnitall . ~lcrosing mucoepidermoid carcinoma wi·th eosinophilia Pcnnsvlvania fMagee Women•s ijof'pitnl) - Medtilhuy carcinoma Pennsylvania <Mt. Nittany Medical Center) - Primary thyroid mucoepidermoid carcinoma Pennsvlvania <Pennsylvania Hospital Residents> - Sclerosing mucoepidennoid carcinoma with eosinophilia Texas llbe Me!hodist tlosrita!) • Sclerosing mucocpidennoid carcinoma with eosinophilia Texa').. Houston .. Sclerosing mucoepidennoid carcinoma with eosinophilia Iexas. Lubbock • Follicular carcinoma West Virginia <Grecnbrjer Valley Medical Center\ • Sclerosing anaplastic carcinoma West Virginia <Wetzel County Hospital) • Thymoma Canada <Pasqua Hospital) • Squamous cell carcinoma Canada CShed>ro9ke University ~lospitall • Ectopic thymoma (2); Papillary carcinoma with squamous metaplasia (2) C'rermany lln>1itut fur Pathologic UKfl) - Sclerosing mucocpidcr:moid carcinoma with eosinophilia Hong Kong<Pwnela Youdc Nethersole Eqstem Uosritall - P"oorly·diffcrcntiated carcinoma, thyroid Qatar <Hamad Medical Comoration) • Sclerosing mucoepidermoid carcinoma with eosinophilia {6); Metastatic squamous cell

carcinoma (2) . Saudi Arabia <King Fab!l!fN!!ljonal Guan! Hospital\ • Ha.mimoto's thyroiditis, fi)>rous type The Netherlands. Amstclvccn • Anaplastic carcinoma· of !be thyroid with squamous differentiation United Kingdom <Oxford Study Gmunl • Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia

Case 8 · Diognosis: Sclerosing mucoepidermoid carcinoma with eosinophilia, thyroid

T-96000, ~-84303

Case 8 -References: Geisinger KR. Stetfee Ctl, McQeeRS, eta! .. The Cytomorphologic Features of Sclerosing Mucoepidermoid Carcinoma ofU>e

'l)lyroid Gland with Eosinophilia. Am J Clin Patho/1998; 109(3):294-301. Sim Sl, RoN, Ordonez NG, ct a!. Sclerosing Mucoepidermoid CarciJ>oma wiO> Eosinophilia of the Thyroid. Report of Two

Patients, One with Distant Metastasis, and Review of the Literature. Hum Palhol !997; 28(9): 1091-1096. Bondes0n Land Bondeson AG. Cytologic Felllllres in Fine-Needle Aspirates from a Sclerosing Mucoepidermoid Tbyr0id

Carcinoma with Eosinophilia. Diagn CytOpalho/1996; 15( 4):30 1·305. Chan 11<. A!bores-Saavedra J, .Battifo.ra H, ct aL S~lcrosing Muooepidermoid Thyroid Carcinoma with Eosinophilia. A Distinctive

Low-Grade Malignancy Arising from the Metapla.o;tie Follicles of Hashimoto's Thyroiditis. Am J Surg Patlw/ 1991 ; 15(5):438· 448.

Soares J, Limbert E and Sobrinbo·Simocs M. Diffuse Sclerosing Variant ofPapill:uy Thyroid Carcinoma. A Clinicopathologic Study of 10 Cases. Pathol Res f'racl t989; 185(2):200-206.


Alameda • Adrenal cortical carcinoma Baldwjn l'w-k !Kaiser Permanentc) • Adrenalcorlical carcinoma (3); Maligrum! ph·eodtromOC)iOma (I) Chico - Adrenal cortical carcinoma ta Jolla <Scripps Health! - Adrenal cortical carcinoma Lone Beach • Neuroendocrine carcinoma, high grade (5) Monterey CCQmmyoity Hosnita).ofthe Monterey PcninsuJal · AdcnocorticaJ carcinoma Oakland • Pheochromocytoma Orange O<aiser Permanentel • Adrenal cortical carcinoma Orange<Qrange €ounw Medjcal Grouol · Adrenal cortical c·axcinoma Orange /UCI Medical Ccnte.rl • Adrenal corfica! carcinoma Oxnard !St. Jobn's Regional Medical Center! -Adrenal cortical carcinoma (2) Sacramento !UC Davi~ Resident~) - Cortica1 carcinoma San Diego /UCSDl - Adrenocortieal carcinoma Snnta Barbara • Adrenal cortical carcinoma

November 2006

Santa Rosa - Adrenal cortical carcinoma with rhabdoid features(!); Adrenocortical carcinoma (I); Adrenal coiticaladcnocarcinoma

12 CITR. November 2006 "Minutes" (Subscription A)

(I) Wpodland Hills !SUllo's Soldiasl - Adrenal corti<:al carcinoma (2) Arbnsas CUniversitv or Arknnll!S for Medical Scjences) • Adrenal cortical carcinoma. adrenal florida, A!neripath - Adrenal carcinoma tlori!la Oacl<son Memorjal Hosnil3ll - Adrcnlll cortical cQI()inoma Florida {Munroe Reoional Medjclll Caller) • Adrenal cortical carcinoma florida Cfal!!!ha.<see Pathology Associates) - Adrenal cortical carcinoma Flods!a £Winter Haven Hospjlall - Adrenocortical carcinoma Geomja CWellsrar Kcnncstope Ho;;pitall • Adrenal cortical carcinoma lt!jnojs rMoeNeal Memorial Hospjtall - Adrenal corticlll carcinoma (2) lt!inojs fHgutland Regional Mediclll <&nterl • Adrenal cortical carcinoma lnd!Ma <Howard Regiopo! Medjcal Center) • Adrenocortical cQI()inoma Ma.<wchusetlS merk.<hjre Medical Center> • Adrenocortical carcinoma MR.<sru;husctts ffiJ!Is-New Enoland Meclical Center Residents) - Adrenocortical carcinoma Michj&ao <Oakwood Hospjhlll • Adrenal cortical carcinoma (2) Ndmh CCtei&hton Unjymi1Yl • Adrenal cortical carcinoma New York <Namw Unlvmitv Medical Centql . Pbcocbromoeytoma New York !SUNY Stony Brookl - Myxoid cortical adrenal carcinoma North Carolina <Mountojn Art• Pathology) - Adrenal corticnl.cnrcinoma (3) Pennsvlyania (Conemaugh Memorial Medical Center) - Adrenal cortical carcinoma Pennsylvania CLcltillh Valley Hosnilall - Adrenal cortical carcinoma Ptnnsylvania<Magee Women•s Hospital) - Adrenocortical carcinoma. Pmp:.-ylyaaia !ML Nittany Mo!!jcal Caltcrl • Malignant composite pbeocbromocytorna, adrenal gland Pennsvlrania IPcnnsvlvania Hospital Residents) - Malignant pheochromocytoma Texas !The Methodist Hgsl!.ili!} - Adrenocortical carcinoma TexM· Houston • Adrenocortical carcinoma TeJSM. L.ubbock - Adrenal corticaL carcinoma Wes! virginia !Greenbrier yallcy Medical CentciJ - Adrenal CW"Cinoma West virginia (Wc:tzx:l Coupty Hoopjtal) • Adrenal cortical carcinoma Canada <Pasaua Hospi!Jil • Adrenal cortical careinoma Canm !Shqbmoke Unjvqsitv Ho;;pj!Jil - Adrenal eortical carcinoma Germany Clnstitut fur Patbologie UK.El • Adrenal cortical carcinoma Hong Kong !pamela Yoyde Ne!her.oolc !las!erp HospjWl • MalignMttumor, favor adrenal cortical carcinoma O!ltar CHamru! Medical Corpomtjonl - Adrenocortical carcinoma Saud! AT8bia CKino Fahad National Guard llgspjlall - Adrenocortical carcinoma The NeJber!ands. AmstcLvcen • Adrenal corticaL carcinoma Unitec! Kjn&dom /Oxford $tydy Grouol - Adrcoal cortical caJcinoma

Ca~ 9 • Diagnosis: Adrenal corticAl carcinoma

T-93100ff·56000, M-83703

Case 9 - References: Stojadinovic A, Brennan MA, Haas A. et a!. Adrenocortical Adenoma and Carcinoma. llistopathoLogical and Molecular

Comparative Analysis. Mod Pmlw/2003; 16(8):742-751. Allolio Band Fassnacht M. Clinical Review. Adrenocortical Carcinoma. C~nical Updal<:. J o[Ciin Endo & Metabo/ 2006;

91(6):2027-2037. Sasooo U. Suzuki T and Moriya T. Disccmln& Malignancy in Rc:scctod Adrenocortical Neoplasms. 6ndo Patho/200L; L2(4):397·

406. ~

~-alis C, Fassnacht M, Willen berg HS, ct aL. Dendritic Cells os Potcotial Adjuvam ror Immunotherapy in Adrenocortical Carcinoma. C/in Endocrino/2006; 65(2):215-222.

Rod&en SE, Evans DB, Lee IE, et al. Adrenocortical Carcinoma. Surg Oncol Clln N Am 2006;. LS(3):S3S-SS3.

Cue No. 10, Accession No. 30389 November 2006

~ - Hodgkin's lymphoma Baldwin Pwl< CKru:;erPerm!l!!cntcl - Hodgkin's lymphoma (nodular sclerosing) (2); ~lodgkin's lymphoma (2) ~ • Hodgkin's lymphoma. nodular sclerosing type 4 Jolla !Sqipns l·lealthl - liodgkin's lymphoma

C1TR. November 2006 --Minutes" (Subscription A) I)

Lon• Beach • Hodgkin's lymphoma, nodu.Jar sc.lerosing type (5) • Monterey (Community Hosnital of the Monterey Peninsula) · Classical Hodgkin's lymphoma, nodular sclerosing type Oakland · Hodgkin's disease(NS) Orange (Kaiser Permancntcl · Hodgkin's disease Orange (Qmnge County Medical Grounl • Hodgkin' s disease Oran•e (UCI Medical Center) · Hodgkin's disease (nodular sclerosing type) Oxnard (St. John's Regional Medical Cen!¢rl • Hodgkin's disease, nodular scleros.ing (2) Sacramento IIJC Davis Residents> • Hodgkin's lymphoma, nodular sclerosing S;m Diego IUCSDl • Nodular sclerosing Hodgkin's lymphoma Santa Bamara • Hodgkin's disease Santa Rosa - Hbdgkin' s lymphoma (3) Woo<ltand Hills (Suda's Soldiers) · Hodgkin's lymphoma vs. diffuse large B-cell with RS-like cells (I); Hodgkin's lymphoma (I) Arkansas (University of Arkansas for Medical Sciences) • Hodgkin's lymphoma, thyroid Florida. Ameripath • Hodgkin's lymphoma Plnrida llackson Memorial H(!spi]all • Hodgkin's disease Florida (Munroe Regional Medical. Center) • Hodgkin's disease F!ori!laiiallah•¥£ Pillhology Associates) · Hodgkin's lymphoma Florida (Winlcr Haven Hospi!Jl!) • liodgkin's disease Georgia <Wcllstar; Kennestone HospitaJl - ALCL vs. HD · lllinojs <MacNeal Memorial Hosoitall • Hodgkin's lymphoma(2) Illinois CHcartland Regional Meclical Genter) • Hodgkin's lymphoma, nodular sclerosis Indiana <Howard Regional Medical Center\ • Hodgkin's disease Massachusetts ffierksbirc Medical eentei\ . Hodgkin's lymphoma Massacbuseus ffufts-New Ens land Medical Center Re>identsl · Hodgkin' s lymphoma. thyroid Michigan <oakwood Hosoitall • Hodgkin's lymphoma, classic lype (2) Nebrnska(Crcigbton University) · Hodgkin's lymphoma, nodular sclerosis type New york (Na.<sau University Medical Center) · Hodgkin's lymphoma: New Yorls (SUNY Stony Brook) • Hodgkin's lymphoma, nodular sclerosing variEUlt North Carolina (Moun!!ljn Area PaJhology.) • Hodgkin's lymphoma (3) Penn.wlvania <Conemaugh Memorial Medica! Center> - Anaplastic large cell lymphoma Pennsv!vaqia <Lehigh Valley HoSpitall · Hodgkin's lymphoma, nodular sclerosing type PcnnsvlvanialMagee Women's Hosnitall . Hodgkints lymphoma Pennsylvania {Mt. Nittany Medical Center! · Hodgkin's lymphoma Pennsylvania <Pennsylvania Ro>pital ResidCOlts) • Nodular sclerosing Hodgkin's Texas (The Me!hodist Hoseital) • Anaplastic large cell lymphoma Texas; Houston · Hodgkin's lympbO)ma. NS type I exa.s. Lubbock· · Hodgkin's lymphoma, nodular sclerosis WeSt Viminja <Greenbtier Valley Medical Center) • Anapl.,iic large cell lymphoma West Virginia (Wetz.el County Hospjtnll · Hodgkin's disease, nodular sclerosis Canada <Pasqua Hospital) • Hodgkih's disease Clinada <Sherl>rooke University Hospital\ • Hodgkin's lymphoma Germany ()nstitut fur Palhnlosie lJKEl • Hodgkin's lymphoma Hong Kong (pii!Dcla Youde Nethefliole Eas!em H9spitall - ~lodgkin's l)mphoma, nodular sclerosis Oatpr Mamad Medical Comorationl • Hodgkin's lymphoma Saudi Arabia {King Fahad National Guar4 Hospital) • Hodgkin's lymphoma The Netherlands. Amstelveen · Hodgkin's lymphoma of the thyroid United Kinodem (Oxford Studv Grouel - Thyroid, nodular sclerosing Hodgkin's lymphoma

Case 10 ·Diagnosis: Nodular sclerosing Hodgkin's lymphoma, thyroid

T-96100, M-96563

Case I 0 • References: Wang SA, Rabemrullah A, Faquin WE, et at. Hodgkin' s Lymphoma of the Thyroid. A Clinicopathologic Study of Five Cases and

&eview of' the Literature. Mod Patho/2005; 1&(12):1577-1584. Aco>1a·Ortega J; MoJltalban-Romero S, Garcia-Solano J, ct a!. Simultaneous Medullary Carcinoma of the Thyroid Gland and

Hodgkin's Lymphoma in Bilateral Lymph Nodes of the Neck. A Potential Pitfall in Fine-Needle Aspiration Cytology. Diagn Cytopatho/2004; 31(4):255-258.

Khurana KK, Stanley MW, Powers GN, et al. Aspiration Cytology of Malignant Neoplasms Associated with Granulomas and Granuloma-Like Fcaturcs. Diagno>1ic Dilemmas. Cancer 1998; 84(2):84-91.

Nakamura S, Mizul<ami K, Yokoyama K, ct a!. Thyroid Tumor as Jnitial Presentation of Hodgkin's Disease. A Case Report Including atll.mmunophenotypic Characterization. Acta Haematologica 1997; 98(4):214-216.

14 CITR: No"cmb<:r 2006 "Minutes" (Subscription A)

Weber AL. Rllllemtullah A 8l!d Ferry JA. Hodgl<in and Non-Hodgkin Lympboma of the Head and Neck. Clinical, Pathologic, and Imaging Ev•luation. Neurofmaging Clin N Am 2003; 13(3):371·392.

C'ITR. November 2006 "Minutes" (Subscription II) 15

california tumor tissue registryheterogeneous right adrenal mass with calcification and central...

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