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CHEMICAL SAFETY PLAN FOR LABORATORIES
CALIFORNIA STATE POLYTECHNIC UNIVERSITYPOMONA
ENVIRONMENTAL HEALTH AND SAFETY DEPARTMENT
Revised: August 15, 2012
California State Polytechnic University, Pomona
Chemical Safety Plan for Laboratories
Table of Contents
1. AUTHORITY....................................................................................
2. BACKGROUND................................................................................
3. UNIVERSITY POLICY.......................................................................
4. SCOPE AND APPLICATION..............................................................
5. OBJECTIVES ................................................................................2
6. RESPONSIBILITIES..........................................................................
7. ELEMENTS OF THE CHEMICAL SAFETY PLAN FOR LABORATORIES....
8. STANDARD OPERATING PROCEDURES ............................................
9. CRITERIA FOR DETERMINING WHICH CONTROL MEASURES SHALL BE IMPLEMENTED..............................................................................
1O. MANAGEMENT OF CONTROL MEASURES AND PROTECTIVE EQUIPMENT.......................................................................................
11. PRIOR APPROVAL FOR HAZARDOUS OPERATIONS.....................18
12. WORK WITH PARTICULARLY HAZARDOUS CHEMICALS...............21
13. ENVIRONMENTAL MONITORING & EMPLOYEE EXPOSURE ASSESSMENT ....................................................................................
14. EMPLOYEE INFORMATION AND TRAINING..................................23
15. MEDICAL MONITORING.............................................................25
16. RECORD KEEPING.....................................................................26
California State Polytechnic University, PomonaChemical Safety Plan for Laboratories
Table of Appendices
Appendix A Occupational Exposure to Hazardous Chemicals in Laboratories
California Code of Regulations, Title 8, Section 5191……………….28
Appendix B Laboratory Safety Inspection Checklist ..…………………………….38
Appendix C Hazard Communication Program Summary………………………….46
Appendix D Training Documentation Form……………………………………….48
Appendix E Chemical Donation Procedure……………………………………….50
Appendix F Chemical Donation Form…………………………………………….52
Appendix G Standard Operating Procedures and Prior Approval Form …….…….55
Appendix H Permissible Exposure Limits for Chemical ContaminantsCalifornia Code of Regulations, Title 8, Section 5155, Table
AC-1...60
Appendix I Signs and Symptoms of Select Agents and Toxins Used inLaboratories………………………………………………………….89
Appendix J Risk Assessment of Work with Toxin andDetermination of Personal Protective Equipment………...
………….91
Appendix K Certification of Annual Review of
Chemical Safety Plan for Laboratories……………………………….93
CALIFORNIA STATE POLYTECHNIC UNIVERSITY, POMONACHEMICAL SAFETY PLAN FOR LABORATORIES
1. AUTHORITY
This Chemical Safety Plan for Laboratories (CSPL) fulfills the requirement of Title 8, California Code of Regulation, Section 5191. The title of that regulation is “Occupational Exposures to Hazardous Chemicals in Laboratories” (see Appendix A). The Regulatory Agency responsible for this regulation is the California Department of Industrial Relations, Division of Occupational Safety and Health (Cal/OSHA).
2. BACKGROUND
It is the University's intent that careful attention be given to the health and safety of all employees and students, and that protection of the environment be maintained. To achieve these goals, this Chemical Safety Plan for Laboratories provides policies and procedures which are to be applied in both teaching laboratories and research laboratories.
Also, the CSPL is the University's document which addresses the State of California regulation concerning exposure to hazardous chemicals in laboratories (Title 8, California Code of Regulations, Section 5191). This regulation states, for example, in Section 5191(c):
For laboratory uses of Cal/OSHA regulated substances, the employer shall ensure that laboratory employees' exposures to such substances do not exceed the exposure limits specified in Title 8, California Code of Regulations, Group 16, Section 5139 et seq., of the General Industrial Safety Orders.
The regulation perhaps is best known for its requirement that "all employers engaged in the laboratory use of hazardous chemicals... shall develop and carry out the provisions of a written Chemical Hygiene Plan...." (8 CCR 5191(a)(1) and (e)(1)). The Plan must be "capable of protecting employees from health hazards associated with hazardous chemicals in that laboratory." (Section 5191(e)(1)(A))
It should be noted that although the term "Chemical Hygiene Plan" is utilized in the regulation, this term is not used at this University. Instead, it is the Chemical Safety Plan for Laboratories (CSPL) which is the document fulfilling all requirements specified in the regulation under the topic "Chemical Hygiene Plan." In addition, the University's CSPL provides comprehensive coverage of the entire regulation (Section 5191), including several requirements which are not actually within the Chemical Hygiene Plan subsections of the regulation.
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Finally, this CSPL recognizes that effective health and safety practices are closely linked to chemical management practices which provide maximum protection for the environment.
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3. UNIVERSITY POLICY
It is the policy of this University that campus laboratory environments where chemicals are used and stored, shall be maintained in such a manner that there shall not be adverse health and safety hazards for University employees, students and visitors. The health and safety of the campus community shall be given priority during all phases of daily activities. The University also supports and promotes procedures designed to reduce the impact on the environment of any hazardous materials used on the campus. To accomplish these goals, the following steps shall be taken:
A. The University shall provide facilities and equipment that meet the requirements of current federal, state and local safety and environmental regulations.
B. The University shall promulgate written procedures, standards and management plans which ensure not only compliance with government regulations but also achievement of University health, safety and environmental goals.
C. All faculty and staff shall ensure that--within the areas under their control--safe and healthful conditions are provided and appropriate safety practices are followed. All members of the campus community shall cooperate fully with all aspects of the various campus health, safety and environmental programs.
D. All faculty and staff shall follow established procedures for disposal of chemical, infectious and radioactive waste, and shall be vigilant in seeking opportunities to reduce the amount of chemical waste generated in laboratories.
E. The procedures outlined in this CSPL shall be continuing efforts, not merely short-term activities.
4. SCOPE AND APPLICATION
The provisions of this Chemical Safety Plan for Laboratories apply to all personnel who work in laboratory environments. The provisions of this Plan apply to, but are not necessarily limited to: faculty; principal investigators; laboratory and stockroom technicians; technical assistants; student employees; building service engineers; and building trades and maintenance staff.
Although Title 8, CCR 5191 legally applies only to employees, it is the policy of the University that any student who is present in a laboratory where hazardous chemicals are in use shall receive appropriate protection from the chemicals and shall be given appropriate training. This includes students
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enrolled in a laboratory class, students providing voluntary unpaid assistance to a faculty or staff member, and students in a laboratory because of a club or other co-curricular activity.
5. OBJECTIVES
The objective of the CSPL is to maintain at lowest possible levels the exposure of employees and students to hazardous chemicals and to provide guidelines that promote the safe use and storage of chemicals in laboratories. The CSPL will also serve to establish an effective system for implementing the following provisions:
A. Employee and student exposures to hazardous chemicals shall be below the established Cal/OSHA Permissible Exposure Levels.
B. The CSPL shall be readily available to all employees and students.
C. The CSPL shall be reviewed annually.
D. There shall be regular laboratory inspections and regular maintenance of laboratory equipment.
E. There shall be additional controls and employee protection when work with particularly hazardous chemicals is undertaken.
F. There shall be an effective employee medical monitoring program.
G. The responsibility of the Principal Investigators and Laboratory Instructors for implementation of the CSPL in their laboratories shall be clearly specified.
H. The responsibility of the Lead Technicians for implementation of the CSPL in the work areas under their control shall be clearly specified.
I. There shall be effective health and safety information and training for employees and students, and appropriate training records shall be maintained.
6. RESPONSIBILITIES
A. University Administration
The campus President has ultimate responsibility for establishing and maintaining effective policies regarding health and safety within the institution. The activities and responsibilities of the Environmental Health and Safety Programs are thereby established under the final authority of the President. Departmental managers are responsible for
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the implementation of Environmental Health and Safety Programs and shall provide continuing support.
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B. Deans, Directors, Department Chairs, Department Heads
It is the responsibility of the Deans, Directors, Department Chairs, and Department Heads to develop departmental procedures to ensure effective compliance with the CSPL and other university health and safety policies as they relate to operations within their departments. Specifically, these individuals will:
1. Identify and appoint a Department Safety Coordinator (DSC).
2. Identify all laboratories in the department.
3. Identify the Principal Investigators or Course Instructors who are responsible for each laboratory.
4. Identify Lead Technicians who are responsible for chemical storage and handling functions in locations outside the physical boundaries of the actual teaching and research laboratories.
5. Ensure that Principle Investigators, Course Instructors and Lead Technicians have received and completed the required Hazard Communications Training and the appropriate CSPL Training. The latter shall include requirements for compliance, elements of the CSPL and specifics regarding the content, methods and documentation of training to be provided to other employees and to students.
6. Review the departmental program quarterly, including:
a. inspection checklists;
b. accident reports;
c. Chemical Safety Committee recommendations;
d. training records;
e. fiscal prioritization.
7. Provide avenue for fiscal requests.
8. Ensure that all chemical inventory procedures are followed.
9. Provide access to Material Safety Data Sheets (MSDSs) when requested.
10. Assist Principle Investigators or Course Instructors in identifying laboratory hazards.
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11. Assist Lead Technicians in identifying hazards in stockrooms or other locations under their control where chemicals are stored or handled outside the physical boundaries of the actual teaching and research laboratories.
12. Review all Requests for Prior Approval and grant approval when appropriate. Maintain related records.
C. Environmental Health and Safety Department (EH&S).
It is the responsibility of EH&S to develop and maintain the CSPL and to monitor compliance. Further responsibilities are outlined below:
1. Provide consultation to administrative personnel, Deans, Directors, Department Chairs, Department Heads and Safety Coordinators regarding program compliance. Consult and advise on issues of: hazard identification and evaluation; correction of unsafe conditions; procedures for obtaining fiscal resources; determining and implementing control measures; employee information and training programs; and employee medical monitoring.
2. Provide centralized monitoring of campus-wide chemical safety activities on a consultative basis.
3. Maintain centralized copies of records and program documentation.
4. Maintain current information on legal requirements concerning regulated substances.
5. Seek ways to improve the CSPL.
6. Verify that appropriate audits are conducted. Review and evaluate the effectiveness of the CSPL and update if necessary.
7. Designate an EH&S staff member to serve as Chemical Safety Officer.
D. Chemical Safety Committee
The Chemical Safety Committee shall function as a cooperative effort between colleges for information dissemination and to ensure that the CSPL procedures are followed. The Committee shall include a member of the Environmental Health and Safety (EH&S) Department who will serve as the committee Chairperson. Department Safety Coordinators appointed to the committee by each department’s Chairperson will make-up the body of the Chemical Safety Committee and will sit as department representatives. The Committee will support the CSPL with the following responsibilities:
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1. Submit and prepare agenda items to be discussed at committee meetings.
2. Assist in dissemination of information and regulatory updates.
3. Provide recommendations to assist in the evaluation of safety suggestions.
4. See that appropriate surveys, inventories and training records are maintained.
5. Assist departments in developing procedures and policies for operational use when necessary.
6. Review and evaluate various departmental safety concerns and regulatory deficiencies.
7. As a committee, collectively prioritize resource allocation to fulfill the safety needs of the various departments.
8. Submit these resource prioritization’s through the appropriate channels to ensure resource allocation.
9. Seek ways to improve the CSPL.
10. Meet at least once each quarter or as requested by the CSC Chairperson.
E. Department Safety Coordinators (DSC)
DSCs are those persons appointed by the Department Chairs or Department Heads to ensure compliance with regulatory guidelines and CSPL procedures. Responsibilities for the DSC’s include but are not limited to the following:
1. Department representative on the Chemical Safety Committee.
2. Liaison with the EH&S office.
3. Assist the departments in development and implementation of EH&S programs.
4. Primary resource person for aiding EH&S activities.
5. Attend established EH&S Train-the-Trainer Programs.
6. Ensure that all department surveys and chemical inventories are completed and returned to the EH&S office in the requested time frame.
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7. Ensure that all copies of the MSDS and training records are forwarded to the EH&S office for centralized record keeping.
8. Ensure that all markings, labeling and identifications per regulatory requirements are in place.
9. Assist and expedite correction of identified deficiencies.
10. Ensure that all regulatory information is disseminated.
11. Provide access to all department employees for safety concerns without fear of reprisal.
12. Prepare written reports and recommendations towards improving compliance with EH&S programs.
13. Maintain an up-to-date listing of all Principal Investigators and Course Instructors who have been designated for laboratory use of chemicals.
14. Maintain an up-to-date listing of all lead technicians who have been given responsibility for chemical storage and handling functions in locations outside the physical boundaries of the actual teaching and research laboratories.
15. Review and maintain a file of SOPs created in the Department.
16. Identify and make available SOPs which are appropriate for use as generic SOPs within the Department.
F. Principal Investigators (PIs) and Course Instructors
Principal Investigators and Course Instructors are faculty or staff who are responsible for particular laboratory or research areas. PIs and Course Instructors will have the following responsibilities:
1. Implement the CSPL in laboratory areas under their control.
2. Identify potential laboratory hazards. 3. Develop site-specific Standard Operating Procedures.
4. Provide employee training at initial assignment and prior to new exposure situations.
5. Maintain training records.
6. Supervise employees and students to ensure that laboratory safety procedures are being followed.
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7. Identify materials considered particularly hazardous (including "select carcinogens," reproductive toxins, and substances which have a high degree of acute toxicity). Establish designated areas when appropriate. (For definition of "high degree of acute toxicity," see below, Section 11(A)(5)).
8. Obtain prior approval from Department Chair for work with particularly hazardous substances and for work involving any of the other unusual situations listed in Section 11(A).
9. Define special circumstances under which employees under their supervision must request approval before engaging in a given work activity.
G. Lead Technicians
Lead Technicians are employees who have primary responsibility for certain chemical storage or handling areas. Lead Technicians will have the following responsibilities:
1. Implement the CSPL in areas under their control.
2. Identify potential chemical hazards. 3. Develop site-specific Standard Operating Procedures
4. Provide employee training at initial assignment and prior to new exposure situations.
5. Maintain training records.
6. Supervise employees and students to ensure that laboratory safety procedures are being followed.
7. Identify materials considered particularly hazardous (including "select carcinogens," reproductive toxins, and substances which have a high degree of acute toxicity). Establish designated areas when appropriate. (For definition of "high degree of acute toxicity," see below, Section 11(A)(5)).
8. Obtain prior approval from Department Chair for work with particularly hazardous substances and for work involving any of the other unusual situations listed in Section 11(A).
9. Define special circumstances under which employees under their control must request approval before engaging in a given work activity.
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H. Laboratory Workers (Instructional Support Technicians, Student Assistants, other employees)
Any employee who works in a laboratory environment is responsible for the following:
1. Plan and conduct each operation in accordance with chemical safety procedures and in accordance with site-specific Standard Operating Procedures.
2. Use good safety judgment at all times.
3. Understand and comply with all EH&S programs. Report any significant problems arising from the implementation of the Standard Operating Procedures (SOPs), to the PI, Course Instructor or Lead Technician.
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4. Report and document all facts pertaining to every accident or "near miss." Report any action or condition that may exist that could result in an accident.
5. Attend scheduled education and training sessions.
6. Ask questions of the PI, Course Instructor or Lead Technician when there is concern about an unknown or a potentially hazardous situations.
7. Understand the function and proper use of all personal protective equipment (PPE). Wear appropriate PPE when required or necessary.
8. Contact the PI, Course Instructor, Lead Technician and/or EH&S if any of the above procedures are not clearly understood.
I. Students
Students are expected to always adhere to safe and healthful work practices defined by written and oral campus and departmental safety and health guidelines. They must also report to a responsible party any laboratory hazard that becomes known to them. Failure to do so will result in the initiation of disciplinary measures.
7. ELEMENTS OF THE CHEMICAL SAFETY PLAN FOR LABORATORIES
This Chemical Safety Plan for Laboratories addresses the following elements:
A. Standard Operating Procedures (SOPs) relevant to safety and health which are to be followed when laboratory work involves the use of hazardous chemicals.
B. Criteria to be used to determine what control measures are appropriate in order to reduce employee exposure to hazardous chemicals, particularly chemicals that are extremely hazardous.
C. A requirement that fume hoods comply with existing regulations, and that specific measures be taken to ensure proper and adequate performance of all protective equipment.
D. Specification of the circumstances under which a particular laboratory operation, procedure, or activity will require prior approval from the PI, Course Instructor or Lead Technician before implementation.
E. Specification of the circumstances under which a PI, Course Instructor or Lead Technician must obtain prior approval from the department
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prior to implementation of a particular laboratory operation, procedure, or activity.
F. Personnel responsible for implementation of the CSPL.
G. Provisions for work with particularly hazardous substances. These include “select carcinogens,” reproductive toxins, and substances which have a high degree of acute toxicity.
H. Provisions for employee information and training.
8. STANDARD OPERATING PROCEDURES
A. Basic Chemical Safety Procedures for Laboratories
The following mandatory safety procedures shall apply in all laboratories where work with chemicals is conducted. The procedures/rules shall also apply in all chemical storage/handling areas associated with a university teaching or research laboratory:
1. Do not taste chemicals or intentionally smell them.
2. Do not eat, drink, smoke, chew gum or apply cosmetics.
3. Do not use mouth suction for pipeting or starting a siphon.
4. Minimize all chemical exposure. Even for substances of no known significant hazard, exposure should be minimized.
5. Avoid horseplay or practical jokes which might startle, distract or confuse another worker.
6. Wear appropriate eye protection.
7. Do not wear sandals or open toed shoes.
8. Use a lab coat or apron to cover legs if you are wearing shorts or a skirt.
9. Do not store food or beverages in refrigerators or cabinets which are used for chemicals or laboratory supplies.
10. Properly secure long hair and loose clothing.
11. Wear appropriate gloves when the potential for contact with toxic materials exists.
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12. All aisles and hallways must be kept clear of furniture or other obstructions. There must be unimpeded access to exits and safety equipment at all times.
13. When inserting glass tubing into stoppers, lubricate the tubing and protect hands with a towel or with leather gloves.
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14. Check equipment before use, and do not use damaged equipment.
15. Stored chemicals shall be examined periodically (at least every 6 months) for replacement, deterioration, container integrity and condition of the label.
16. Wash hands thoroughly with soap and water after working with chemicals.
17. Familiarize yourself with the location of safety equipment.
18. All hazardous chemicals or other hazardous substances shall be transported in secondary containment that is sufficient to contain any leaks or spills. The use of a cart for this purpose is standard practice.
B. Laboratory-Specific Standard Operating Procedures
Principal Investigators, Course Instructors, and Lead Technicians shall evaluate the chemicals and procedures used in the areas under their control. Based on this evaluation they shall create a written Standard Operating Procedure which shall be attached to and become a part of the CSPL for their laboratory. The SOP shall:
1 Provide a clear description of the chemicals that will be used and the procedures that will be followed.
2. Provide a logical sequence for workers to follow.
3. Describe the steps to be taken to minimize the exposure of laboratory workers to hazardous chemicals. Discuss engineering controls and personal protective equipment.
4. Indicate any procedures which require prior approval from the Principal Investigator.
5. Describe, where appropriate, special precautions to be used to deal with particularly hazardous substances.
6. Take into account the background and experience of the workers who will conduct a laboratory procedure. Although Departments are encouraged to develop generic SOPs for certain simple processes, a Principal Investigator, Course Instructor or Lead Technician may need to provide additional information in a SOP if workers lack sufficient experience with laboratory chemicals.
7. The SOP, together with a copy of the CSPL, shall be readily available in the applicable laboratory or stock room.
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8. A copy of the SOP shall be provided to the Department Safety Coordinator prior to the start of the procedure.
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C. Standard Operating Procedures for Botulinum Neurotoxin are included in the Biosafety Plan for Clostridium botulinum & Botulinum Neorotoxin.
D. Sources of Information
A number of sources of information are available for individuals who are preparing SOPs:
1. The publication Prudent Practices in the Laboratory (1995) contains 88 Laboratory Chemical Safety Summaries for chemicals ranging from acetaldehyde and acetic acid to trimethylaluminum and trimethyltin chloride. The Chemical Safety Summaries include information concerning toxicity, reactivity, incompatibility, storage, handling, accidents, disposal, etc.
2. Howard Hughes Medical Institute (http://www.hhmi.org).
3. The Cal Poly Standard Operating Procedures and Prior Approval Form may be used as a template (see Appendix G).
4. The American Chemical Society (http://portal.acs.org)
9. CRITERIA FOR DETERMINING WHICH CONTROL MEASURES SHALL BE IMPLEMENTED
A. Recognition of Potential Hazards
Principal Investigators, Course Instructors and Lead Technicians are responsible for recognizing potential hazards in work areas under their jurisdiction. This requires familiarity with the processes and work operations involved, maintenance of an inventory of the chemicals associated with those processes, and periodic review of the different research or instructional activities in a work area. Consideration shall be given to the level of expertise of the individuals working in any area and the level of training they have received. The basic chemical safety rules required as a Standard Operating Procedure in all laboratories and storage/handling areas (see above, Section 8(A)) serve to provide a measure of health and safety protection. However, Principal Investigators, Course Instructors and Lead Technicians must continually review the types of hazards created by the chemicals being used and make determinations as to the effectiveness of existing control measures.
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B. Hazard Identification
In order to be able to assess hazards, a good system of records is needed to provide information about all chemicals. Key elements in the system are the following:
1. Labeling
Principal Investigators, Course Instructors and Lead Technicians will ensure that labels on newly received containers of hazardous chemicals are not removed or defaced and that all primary and secondary containers meet the minimum requirements for labeling as discussed in the Cal Poly Pomona manual “Employee's Guide To Container Labels.”
2. Chemical Inventory and Material Safety Data Sheets (MSDSs)
Principal Investigators, Course Instructors and Lead Technicians will be responsible for maintaining a complete chemical inventory and a file of Material Safety Data Sheets. MSDSs will be made available to any employee upon submittal of the Cal Poly MSDS Employee Request Form.
3. Hazardous Chemicals Produced in the Laboratory
a. If the chemical composition is known and the chemical is produced exclusively for the laboratory of origin, the Principal Investigator, Course Instructor or Lead Technician shall determine if it is hazardous as defined in Appendix A. If it is a hazardous chemical, the PI, Course Instructor or Lead Technician shall provide and document training.
b. If the chemical produced is a by-product with an unknown composition, the PI, Course Instructor or Lead Technician shall assume that the substance is a hazardous chemical and shall implement the applicable sections of the CSPL.
c. Any chemical substance produced in a chemical laboratory may not be transferred to a user outside the Department, unless special procedures are followed. Contact EH&S for assistance in this matter.
d. Laboratory-prepared solutions of hazardous chemicals must be labeled with the identity of the chemical and an appropriate health and physical hazard warning. The identification used shall permit cross-referencing to the laboratory's MSDS collection.
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C. Evaluation of Potential Hazards
Departments, in conjunction with Environmental Health and Safety, shall perform evaluations of the degree of risk arising from exposure to chemical, physical and biological agents. Risk evaluation involves making judgments based on observations and detailed measurements of the potential exposure to these agents. Risk evaluation also involves determining:
1. Toxicity level and quantity of chemical agents.
2. Routes of entry.
3. Possibility of reaction with another agent (either chemical or physical).
4. Length or duration of exposure.
5. Airborne concentration levels of air contaminants arising from a process or work operation.
6. Effectiveness of any control measures used.
D. Exposure Control
1. Exposure levels to hazardous materials shall be kept below the established Action Levels. In the absence of Action Levels, exposure shall not exceed the Permissible Exposure Level (PEL). Action level criteria are also provided on the PEL list. MSDS’s and the Environmental Health and Safety Department can also provide this information.
2. Exposure control measures shall be employed by departments to eliminate or reduce to the lowest practical level, employee exposure to airborne contaminants. This may be done by one or more of the following types of control measures.
E. Types of Control Measures
The following are the three types of mandated control measures. Departments, in cooperation with the Environmental Health and Safety Department, shall establish effective and practical exposure control methods based on departmental needs and regulatory mandates.
1. Engineering Controls - Methods of controlling employee exposures by reducing the quantity of contaminants released into the workroom environment (e.g., fume hoods, glove boxes, local exhaust systems), or by modifying the source (using a substitute which is less hazardous).
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2. Administrative Controls - Methods of controlling employee exposures to contaminants by job rotation, work assignment or time periods away from the contaminant.
3. Personal Protective Equipment (PPE) - Includes respirators and other protective equipment or devices. PPE shall only be considered as a secondary alternative to the use of engineering and administrative controls.
F. Selection
Departments, with the assistance of EH&S, shall always attempt to first design safety into a potentially hazardous process. Only when engineering controls are determined to be ineffective or impractical shall administrative controls be considered. The use of Personal Protective Equipment (PPE) to achieve exposure levels below PELs shall be considered only when all other options have been found to be ineffective or impractical.
G. Review and Updating
The level of severity of hazards and potential hazards typically changes over time. For this reason, departments shall continually review, evaluate and update health hazard control measures.
10. MANAGEMENT OF CONTROL MEASURES AND PROTECTIVE EQUIPMENT
A. General Laboratory Ventilation
1. The University shall provide general chemical laboratory ventilation systems which are managed to achieve the following:
a. Compliance with the American Society of Heating Refrigeration and Air Conditioning Engineers (ASHRAE) Handbook of Fundamental Guidelines, the Uniform Building Code, and Title 8, California Code of Regulations, Section 5142.
b. The system operates continuously during working hours.
c. The system provides a source of air for breathing and for input to local ventilation devices.
d. The general ventilation system is not relied on for protection from toxic substances released into the laboratory.
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e. Laboratory air is continually replaced, thus preventing a build-up of toxic or odoriferous air concentrations during the work day. The system shall provide six (6) to twelve (12) room air changes per hour.
f. Air pressure in chemical laboratories is negative with respect to the rest of the building.
g. Air flow is directed into the laboratories from non-laboratory areas. All air from chemical laboratories is directed out to the exterior of the building.
h. Systems are inspected at least annually. Problems found during these inspections shall be corrected within a reasonable time.
2. General ventilation shall only be used as method for control of airborne toxic substances when local exhaust systems are impractical.
3. General ventilation rates within a given workplace shall be calculated based on the types and location of air supply vents, location of people in the room, and relative toxicity of the vapor(s).
B. Local Exhaust Ventilation
1. The University shall only use local exhaust ventilation systems when every effort has been made to control the contaminant by isolation, a change in the process, or by substitution of a less harmful substance.
2. Laboratory apparatus that may discharge dangerous levels of toxic vapors, such as vacuum pump exhausts, gas chromatograph exit ports, and distillation columns, shall vent to an exhaust device such as a snorkel.
3. Local exhaust systems shall be utilized for control if:
a. The contaminant in the atmosphere constitutes a health, fire, or explosion hazard.
b. Regulations require local exhaust ventilation for a particular process.
c. Emission sources are large, few and fixed, or widely dispersed.
d. Emission sources are near the employee breathing zone.
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e. Emission rates vary widely by time.
C. Laboratory Fume Hoods
1. General Guideline for Fume Hood Operation
a. Fume hood exhaust fans should be kept on at all times when an experiment is in progress.
b. All work should be performed by reaching under the sash and keeping the glass between the worker and the chemical.
c. Place chemical sources at least 6 inches behind the face of the hood.
d. In order to ensure that air flows easily around all instruments, apparatus should be separated and elevated.
e. People should not walk rapidly past a fume hood, as this may create cross draft.
f. Fume hoods should have a continuous monitoring device which can be checked every time the hood is used.
g. Fumes hoods should not be used for storage of chemicals.
2. Testing
a. Fume Hoods shall be tested annually.
b. In general, the face velocity of a fume hood shall be maintained between 100 and 120 feet per minute.
c. Proper flow shall be checked using smoke tubes or fog generators.
D. Flammable Solvent Hazard Control
1. Departments shall provide for safe handling of flammable liquids, regardless of the quantities involved. Problems associated with each flammable liquid shall be analyzed to determine the extent of flammability and health hazards so that appropriate control measures can be taken.
2. To control these hazards, departments shall consider the characteristics of the specific substance in use, the amounts of vapor involved, potential ignition sources, the kinds of
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operations, unsafe temperatures, ventilation and type of building construction.
3. Departments shall determine the necessity of safeguarding electrical equipment; ventilation requirements; the need for eliminating sparks, open flames and other sources of ignition; safe material handling procedures; proper grounding procedures; and other factors promoting the maintenance of a safe work environment.
4. Flammable liquids shall be stored in flammable cabinets when not in use and always at the end of a work day.
5. Departments shall obtain and use proper safety devices to protect workers from the possible hazards associated with flammable liquids.
E. Emergency Eyewashes and Safety Showers
1. Location
a. Emergency eyewash facilities and safety showers shall be installed in easily accessible locations that require no more than 10 seconds for the injured person to reach.
b. If both an eyewash and shower are needed, they shall be located so that an individual can use both at the same time.
c. The area around the eyewash and shower equipment shall be maintained free of items which could obstruct their use.
2. Performance
a. The control valve shall be designed so that the water flow remains on without requiring the use of the operator's hands, and so that the valve remains activated until intentionally shut off,
b. Personal eyewash units shall deliver tempered clean potable water or an approved eye-flushing solution for a minimum of 15 minutes continuously.
3. Maintenance
a. Eyewash and shower equipment shall be activated by Department Safety Coordinator or designee at least monthly to flush the line and to verify proper operation.
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b. Other units shall be maintained in accordance with the manufacturers instructions.
11. PRIOR APPROVAL FOR HAZARDOUS OPERATIONS
A. Prior Approval by the Department Chairperson or Department Head.
Occasionally, a particular laboratory operation, procedure, or activity will require prior approval. The Principal Investigator, Course Instructor or Lead Technician shall obtain approval from the Department Chairperson or Department Head. The following are examples of circumstances that will require such approval. Circumstances are not limited to these examples:
1. When the likelihood of exceeding the Action levels or PEL is suspected, or is indicated during the Evaluation of Potential Hazards process (see above, Section 9(c)).
2. Whenever work will be performed outside the normal operating hours of the laboratory.
3. Whenever experiments will involve one person working alone. If an experiment is known to be hazardous, it may not be conducted by one person working alone; however, permission may be granted for less dangerous work, provided a Principal Investigator establishes procedures for the lone worker to be checked on periodically.
4. Whenever operations with hazardous chemicals will take place when no one is present. For such operations, appropriate signs must be posted and laboratory lights must be left on. Precautions must be taken to ensure that no hazardous chemicals will be released if utility service should fail.
5. Whenever an experiment involves a highly toxic substance. A "highly toxic substance" is defined as one which falls into any of the following categories:
a. A substance that has a median lethal dose (LD50) of 50 milligrams or less per kilogram of body weight when administered orally to albino rats weighing between 200 and 300 grams each.
b. A substance that has a median lethal dose (LD50) of 200 milligrams or less per kilogram of body weight when administered by continuous contact for 24 hours (or less if death occurs within 24 hours) with the bare skin of albino rabbits weighing between two and three kilograms each.
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c. A substance that has a median lethal concentration (LC50) in air of 200 parts per million by volume or less of gas or vapor, or 2 milligrams per liter or less of mist, fume, or dust, when administered by continuous inhalation for one hour (or less if death occurs within one hour) to albino rats weighing between 200 and 300 grams each. (8 CCR, Appendix to Section 5194)
B. Approval Procedure
1. The request for approval shall be made by submitting a proposal to the Department Chair/Head for review with a copy to EH&S. A Department may elect to have a preliminary review carried out by the DSC who will forward the request to the Chair.
2. The proposal shall include the following:
a. Description of the project, process or test.
b. Hazardous materials that will be used (MSDSs for each material).
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c. Specification of the safety precautions to be used at each step of the process.
d. Possible exposure hazards.
e. Control measures utilized (engineering, administrative or personal protective equipment)
f. Flow sheet of the process showing the substances and equipment that will be used.
g. The proposed handling procedure of the products, by-products, and waste material.
h. Location and expected duration of the project, process or test.
3. The request shall be made using the Prior Approval Form (Appendix G); additional pages may be attached if necessary.
4. If the required description of Standard Operating Procedures (see above, Section 8) has already been prepared, that document may contain most of the information needed in the application for prior approval.
5. If the project or process is approved, a copy of the Prior Approval Form containing the signature of the Chair shall be kept in the applicable laboratory together with the CSPL and the SOP.
6. If the project or process is approved, the project requester and Department Chair/Head shall meet to ensure that all hazards, prescribed safety procedures and control measures of the project are known. The project requester and/or PI shall ensure workplace controls are in place prior to starting a new procedure. If there is a potential for an employee exposure, monitoring shall be conducted in the beginning phases of the new procedure to ensure exposures are below PELs. Employee exposure monitoring data will be performed by EH&S and made readily available to the employees being monitored.
7. Prior approval by the Chair is granted for a maximum of 3 months (90 days).
C. Prior Approval to Be Obtained from the Principal Investigator, Course Instructor or Lead Technician
In preparing Standard Operating Procedures, Principal Investigators, Course Instructors and Lead Technicians shall specify any
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circumstances under which the workers they are supervising must obtain prior approval.
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D. Departmental Review of an Existing Program
In order that appropriate departmental review of on-going programs may occur, notification in writing to the Department Chairperson or Department Head shall be made concerning any newly identified or suspected hazards. Laboratory related injuries or illnesses are also reportable. Follow notification procedures described on the hazard communications poster, and send copies to EH&S. The following are situations where Departmental review shall be conducted:
1. Whenever there is a change in toxicological data (resulting in an increased hazard potential).
2. When an injury or illness has occurred as a result of a new process, product, or procedure, or due to an exposure to a hazardous chemical.
3. When faculty, staff or others have been accidentally exposed to a hazardous chemical, or otherwise suspect ineffective or inappropriate safeguards.
4. Whenever an existing (previously unidentified) hazard is discovered or suspected.
12. WORK WITH PARTICULARLY HAZARDOUS CHEMICALS
Departments shall follow special procedures when performing laboratory work with particularly hazardous substances, including “select carcinogens,” reproductive toxins, and substances which have a high degree of acute toxicity. (Special control measures are also in place on this campus for radioactive materials; these are found in the Radiation Safety Manual, California State Polytechnic University, Pomona) Work with particularly hazardous chemicals requires that the following provisions be considered and included where appropriate:
A. Careful planning shall precede any work with high toxicity substances.
1. A determination shall be made as to special requirements, such as training or documentation, that may be required by state or federal regulations.
2. The experiment plan shall be reviewed by experienced personnel.
3. Consideration shall be given to reducing risk by substitution of a less toxic substance and by using the smallest amount of a substance that is practical.
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4. Planning shall include methods for managing a substance throughout its entire life cycle, from acquisition and storage through eventual safe disposal.
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B. Designated areas shall be established, and work with highly toxic chemicals shall be restricted to these areas.
1. These areas must be a restricted access hood, glove box, or portion of a laboratory designated for use of the particularly hazardous substances.
2. Designated areas shall be clearly indicated by signage, and the boundaries of such areas shall be clearly marked.
3. Access to these areas shall be allowed only to persons who are directly involved in the laboratory work and who have been informed of the special precautions required. Only those persons with demonstrated knowledge and ability to work with particularly hazardous substances shall work with chemicals in the designated area.
C. Containment devices, such as fume hoods or glove boxes, shall be used when handling particularly hazardous chemicals which are volatile; when procedures involve manipulations that may result in the generation of an aerosol or airborne dust; and with any manipulation, handling, or reaction that may result in the uncontrollable release of the substance.
D. Special consideration shall be given to planning for accidents and spills. Emergency response procedures may be the last line of defense when working with highly toxic chemicals.
1. Laboratory workers should be trained in the use of spill control and emergency response kits.
2. Emergency response kits should not be stored within the immediate area where a highly toxic substance is being handled. Otherwise, the equipment could be inaccessible or contaminated in case of an accident.
3. Prior to the start of an experiment, the contents of the emergency response kit should be verified.
E. Decontamination procedures shall be designed based on laboratory circumstances.
F. Removal of contaminated wastes shall involve approved safety procedure.
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13. ENVIRONMENTAL MONITORING AND EMPLOYEE EXPOSURE ASSESSMENT
A. Environmental Monitoring
Regular monitoring of airborne chemical concentrations is not usually justified or practical in laboratories because chemicals are used for short periods of time and in small quantities. However, monitoring may be appropriate when testing or redesigning hoods or other ventilation devices, or when a highly toxic or hazardous substance is stored or used regularly.
B. Exposure Assessment
1. Monitoring needs will be identified by the department during laboratory safety inspections or when a Request for Prior Approval is received from a Principal Investigator or Laboratory Instructor. In addition, if there is a risk or concern of potential employee overexposure, departments will evaluate potential exposures on a case by case basis.
2. When an exposure risk is identified or suspected, notification shall be made to the Environmental Health and Safety Department which will employ appropriately approved industrial hygiene practices and procedures to assess the level of airborne chemical concentrations.
14. EMPLOYEE INFORMATION AND TRAINING
A. Frequency of Training
Employees shall be informed and trained on the hazards of chemicals present in the work area. Such information shall be provided at the time of an employee's initial assignment to a work area where hazardous chemicals are present, prior to starting a new assignment involving previously unused hazardous chemicals, or when work is commenced in an unfamiliar laboratory environment or with unfamiliar procedures.
B. Employee Information
Employees shall be informed of the following:
1. The contents of the CSPL and its appendices, which shall be made available to all employees.
2. The location and availability of the CSPL.
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a. Master copies of the CSPL will be kept by the Deans, Directors, Department Chairs and Department Heads responsible for laboratory areas, and at EH&S.
b. The CSPL will be available for review during normal work hours, and additional copies may be distributed to employees as appropriate.
c. A copy of the CSPL shall be kept in each laboratory or stock room together with the SOP for that laboratory. In teaching the case of laboratories, the CSPL may be kept in the Department office.
3. The contents of Title 8 of the California Code of Regulations, Section 5191.
4. The exposure limits for Cal/OSHA regulated substances, or the recommended exposure limits for other hazardous chemicals where there is no applicable Cal/OSHA regulation. The following reference sources can be used to obtain this information:
a. Cal/OSHA Airborne Contaminants (see Appendix H).
b. American Conference of Governmental Industrial Hygienists, Threshold Limit Values {ACGIH, TLVs} (Contact Environmental Health & Safety for access to a copy of this publication).
c. Material Safety Data Sheets (Obtain directly from Manufacurer or Contact Environmental Health & Safety).
d. Environmental Health and Safety Department.
5. Signs and symptoms associated with exposures to hazardous chemicals used in the laboratory. This information can be found in the MSDSs for the chemical(s) in use. Additionally, the Signs and symptoms associated with exposures to some select agents and Toxins are available in Appendix J of this plan.
6. The location and availability of known reference materials on the hazards, safe handling, storage and disposal of hazardous chemicals, including, but not limited to, MSDSs received from the chemical supplier.
C. Employee Training
Employee Training should be initiated at the time of an employee's initial assignment to a work area where hazardous chemicals are
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present, and prior to an assignment which involves a new type of chemical exposure. Employee training shall include:
1. Methods and observations that may be used to detect the presence or release of a hazardous chemical (i.e. continuous monitoring devices, visual appearance or odor of hazardous chemicals, etc.). These methods and observations are listed below:
Methods and Observation to Detect the Presence of a Spill or Release of Botulinum Toxin The presence of broken containers. The presence of overturned containers with missing
lids The presence of a somewhat reflective clear film on
cabinets, counters or other equipment, etc. The presence of a rotten garbage smell which is a
description of the odor of Clostridium Botulinum bacteria which may be presence in some samples of Botulinum.
The presence of any strange or unusual odor. The presence of a color or odor matching the
information for a particular hazardous substance (Refer to Material Safety Date Sheet).
2. The physical and health hazards of chemicals in the work area.
3. The methods of protection from potential hazards, including specific University, campus, or departmental procedures that have been implemented to protect employees from exposure to hazardous chemicals (i.e. appropriate work practices, emergency procedures, personal protective equipment, etc.).
4. The Standard Operating Procedures which have been developed for the particular laboratory in which the employee will be working.
5. Whenever employees are trained, records shall be kept to document that this training has occurred. The Training Documentation Form (Appendix D) shall be used for this purpose.
15. MEDICAL MONITORING
A. The University Medical Monitoring Program is designed to assist in the maintenance of employee health and to ascertain the effectiveness of hazard control methods. Certain laboratory workers who work with hazardous chemicals shall be provided an opportunity to receive
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medical consultation and examination. Employees who meet specific criteria shall be provided with appropriate medical consultation and exams at no cost to the employees, without loss of pay, and at a reasonable time and place. The circumstances under which medical consultation for an employee may be appropriate include the following:
1. Whenever an employee develops signs or symptoms associated with a hazardous chemical to which the employee may have been exposed in the laboratory.
2. Whenever exposure monitoring reveals an exposure level above the action level (or in the absence of an action level, the exposure limit) for a Cal/OSHA regulated substance for which there are exposure monitoring and medical surveillance requirements. In such circumstances, medical surveillance shall be established for the affected employee as prescribed by the particular standard.
3. Whenever an event takes place in the work area, such as a spill, leak, explosion or other occurrence resulting in the likelihood of a hazardous exposure. In such circumstances, consultation with a physician shall be for the purpose of determining the need for a medical examination.
B. Information Provided to Physician
The following information shall be provided to the physician:
1. The identity of the hazardous chemical(s) to which the employee may have been exposed.
2. A copy of the MSDS for the chemical to which the employee may have been exposed.
3. A description of the conditions under which the exposure occurred, including quantitative exposure data, if available.
4. A description of the signs and symptoms of exposure that the employee is experiencing, if any.
C. Physician's Written Opinion
1. A written report from the physician to whom the employee was referred, must be provided to the of Environmental Health and Safety Department. The report shall include the following:
a. Any recommendation for further medical follow-up.
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b. The results of the medical examination and any associated tests, if requested by the employee.
c. Any medical condition which may be revealed in the course of the examination which may place the employee at increased risk as a result of exposure to a hazardous chemical found in the workplace.
d. A statement that the employee has been informed by the physician of the results of the consultation or medical examination and any medical condition that may require further examination or treatment.
2. The written opinion shall not reveal any specific findings or diagnoses unrelated to the hazardous exposure.
16. RECORD KEEPING
A. Records related to occupational injuries and illnesses, exposure monitoring, inspections and other activities and incidents relevant to occupational health and safety shall be kept by EH&S and individual departments. Detailed responsibilities and procedures are contained in the University IIPP Policy.
B. Where medical monitoring is required, individual medical surveillance records shall be kept by EH&S and are subject to strict privacy regulations. Access to these records by departmental committees, designated PIs, course instructors, or anyone else other than the employee can only be done with a written approval by the employee. Written record access approvals are subject to verification prior to release of documents. Employees requesting copies of these records must provide appropriate identification.
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APPENDIX A
Occupational Exposure to Hazardous Chemicals in Laboratories
California Code of Regulations, Title 8, Section 5191
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§5191. Title 8, CCR
Occupational Exposure to Hazardous Chemicals in Laboratories
(a) Scope and application.(1) This section shall apply to all employers engaged in the laboratory use of
hazardous chemicals as defined below.(2) Where this section applies, it shall supersede, for laboratories, the
requirements of Title 8 of the California Code of Regulations Section 5190 and Article 110, Regulated Carcinogens of the General Industry Safety Orders, except as follows:
(A) The requirement to limit employee exposure to the specific exposure limit.
(B) When that particular regulation states otherwise, as in the case of Section 5209(c)(6).
(C) Prohibition or prevention of eye and skin contact where specified by any health regulation shall be observed.
(D) Where the action level (or in the absence of an action level, the exposure limit) is exceeded for a regulated substance with exposure monitoring and medical surveillance requirements.
(E) The "report of use" requirements of Article 110, (Section 5200 et. seq.) Regulated Carcinogens regulations.
(F) Section 5217 shall apply to anatomy, histology and pathology laboratories.
(3) This regulation shall not apply to:(A) Uses of hazardous chemicals which do not meet the definition of
laboratory use, and in such cases, the employer shall comply with the relevant regulations in Title 8, California Code of Regulations, even if such use occurs in a laboratory.
(B) Laboratory uses of hazardous chemicals which provide no potential for employee exposure. Examples of such conditions might include:
1. Procedures using chemically-impregnated test media such as Dip-and-Read tests where a reagent strip is dipped into the specimen to be tested and the results are interpreted by comparing the color reaction to a color chart supplied by the manufacturer of the test strip; and
2. Commercially prepared kits such as those used in performing pregnancy tests in which all of the reagents needed to conduct the test are contained in the kit.
(b) DefinitionsAction level. A concentration designated in Title 8, California Code of Regulations for a specific substance, calculated as an eight (8)-hour time weighted average, which initiates certain required activities such as exposure monitoring and medical surveillance.Carcinogen (see "select carcinogen").Chemical Hygiene Officer. An employee who is designated by the employer, and who is qualified by training or experience, to provide technical guidance in the development and implementation of the provisions of the Chemical Hygiene Plan. This definition is not intended to place limitations on the position description or job
37
classification that the designated individual shall hold within the employer's organizational structure.
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§5191. Title 8, CCR
Chemical Hygiene Plan. A written program developed and implemented by the employer which sets forth procedures, equipment, personal protective equipment and work practices that
(1) are capable of protecting employees from the health hazards presented by hazardous chemicals used in that particular work place and
(2) meets the requirements of subsection 5191(e).Chief. The Chief of the Division of Occupational Safety and Health.Combustible liquid. Any liquid having a flash point at or above 100 o F (37.8 o C), but below 200 o F (93.3 o C) except any mixture having components with flash points of 200 o F (93.3 o C), or higher, the total volume of which make up 99 percent or more of the total volume of the mixture.Compressed gas.
(1) A gas or mixture of gases having, in a container, an absolute pressure exceeding 40 psi at 70o F (21.1o C); or
(2) A gas or mixture of gases having, in a container, an absolute pressure exceeding 104 psi at 130o F (54.4o C) regardless of the pressure at 70o F (21.1o C); or
(3) A liquid having a vapor pressure exceeding 40 psi at 100o F (37.8o C) as determined by ASTM D-323-72.Designated area. An area which may be used for work with "select carcinogens," reproductive toxins or substances which have a high degree of acute toxicity. A designated area may be the entire laboratory, an area of a laboratory or a device such as a laboratory hood. Emergency. Any occurrence such as, but not limited to, equipment failure, rupture of containers or failure of control equipment which results in an uncontrolled release of a hazardous chemical into the workplace.Employee. An individual employed in a laboratory workplace who may be exposed to hazardous chemicals in the course of his or her assignments.Explosive. A chemical that causes a sudden, almost instantaneous release of pressure, gas, and heat when subjected to sudden shock, pressure, or high temperature.Flammable. A chemical that falls into one of the following categories:
(1) "Aerosol, flammable" means an aerosol that, when tested by the method described in 16 CFR 1500.45, yields a flame projection exceeding 18 inches at full valve opening, or a flashback (a flame extending back to the valve) at any degree of valve opening;
(2) "Gas, flammable" means:(A) A gas that, at ambient temperature and pressure, forms a flammable
mixture with air at a concentration of 13 percent by volume or less; or(B) A gas that, at ambient temperature and pressure, forms a range of
flammable mixtures with air greater than 12 percent by volume, regardless of the lower explosive limit.
(3) "Liquid, flammable" means any liquid having a flash point below 100o F (37.8o C), except any mixture having components with flash points of 100o F (37.8o C) or higher, the total of which make up 99 percent or more of the total volume of the mixture.
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§5191. Title 8, CCR
(4) "Solid, flammable" means a solid, other than a blasting agent or explosive as defined in 29 CFR 1910.109(a), that is liable to cause fire through friction, absorption of moisture, spontaneous chemical change, or retained heat from manufacturing or processing, or which can be ignited readily and when ignited burns so vigorously and persistently as to create a serious hazard. A chemical shall be considered to be a flammable solid if, when tested by the method described in 16 CFR 1500.44, it ignites and burns with a self-sustained flame at a rate greater than one-tenth of an inch per second along its major axis. Flashpoint. The minimum temperature at which a liquid gives off a vapor in sufficient concentration to ignite when tested as follows:
(1) Tagliabue Closed Tester (See American National Standard Method of Test for Flash Point by Tag Closed Tester, Z11.24 - 1979 (ASTM D 56-79) - for liquids with a viscosity of less than 45 Saybolt Universal Seconds (SUS) at 100 o F (37.8 o C), or that do not contain suspended solids, and do not have a tendency to form a surface film under test; or
(2) Pensky-Martens Closed Tester (see American National Standard Method of Test for Flash Point by Pensky-Martens closed tester), Z11.7 - 1979 (ASTM D 93-79) for liquids with a viscosity equal to or greater than 45 SUS at 100 o F (37.8 o C), or that contain suspended solids, or that have a tendency to form a surface film under test; or
(3) Setaflash Closed Tester (see American National Standard Method of Test for Flash Point by Setaflash Closed Tester (ASTM D 3278-78)). Organic peroxides, which undergo auto-accelerating thermal decomposition, are excluded from any of the flash point determination methods specified above.Hazardous chemical. A chemical for which there is statistically significant evidence based on at least one study conducted in accordance with established scientific principles that acute or chronic health effects may occur in exposed employees. The term "health hazard" includes chemicals which are carcinogens, toxic or highly toxic agents, reproductive toxins, irritants, corrosives, sensitizers, hepatotoxins, nephrotoxins, neurotoxins, agents which act on the hematopoietic systems, and agents which damage the lungs, skin, eyes, or mucous membranes. Appendices A and B of the Hazard Communication Standard (Section 5194) provide further guidance in defining the scope of health hazards and determining whether or not a chemical is to be considered hazardous for purposes of this regulation.Laboratory. A facility where the "laboratory use of hazardous chemicals" occurs. It is a workplace where relatively small quantities of hazardous chemicals are used on a non-production basis.Laboratory scale. Work with substances in which the containers used for reactions, transfers, and other handling of substances are designed to be easily and safely manipulated by one person. "Laboratory scale" excludes those workplaces whose function is to produce commercial quantities of materials.Laboratory-type hood. A device located in a laboratory, enclosed on five sides with a movable sash or fixed partial enclosure on the remaining side; constructed and maintained to draw air from the laboratory and to prevent or minimize the escape of air contaminants
40
§5191. Title 8, CCR
into the laboratory; and allows chemical manipulations to be conducted in the enclosure without insertion of any portion of the employee's body other than hands and arms.Walk-in hoods with adjustable sashes meet the above definition provided that the sashes are adjusted during use so that the airflow and the exhaust of air contaminants are not compromised and employees do not work inside the enclosure during the release of airborne hazardous chemicals.Laboratory use of hazardous chemicals. Handling or use of such chemicals in which all of the following conditions are met:
(1) Chemical manipulations are carried out on a "laboratory scale";(2) Multiple chemical procedures or chemicals are used;(3) The procedures involved are not part of a production process, nor in any way
simulate a production process; and(4) "Protective laboratory practices and equipment" are available and in common
use industry-wide to minimize the potential for employee exposure to hazardous chemicals.
Medical consultation. A consultation which takes place between an employee and a licensed physician for the purpose of determining what medical examinations or procedures, if any, are appropriate in cases where a significant exposure to a hazardous chemical may have taken place.Organic peroxide. An organic compound that contains the bivalent -o-o- structure and which may be considered to be a structural derivative of hydrogen peroxide where one or both of the hydrogen atoms has been replaced by an organic radical.Oxidizer. A chemical other than a blasting agent or explosive as defined in Section 5237(a), that initiates or promotes combustion in other materials, thereby causing fire either of itself or through the release of oxygen or other gases.Physical hazard. A chemical for which there is scientifically valid evidence that it is a combustible liquid, a compressed gas, explosive, flammable, an organic peroxide, an oxidizer, pyrophoric, unstable (reactive) or water-reactive.Protective laboratory practices and equipment. Those laboratory procedures, practices and equipment accepted by laboratory health and safety experts as effective, or that the employer can show to be effective, in minimizing the potential for employee exposure to hazardous chemicals.Reproductive toxins. Chemicals which affect the reproductive capabilities including chromosomal damage (mutations) and effects on fetuses (teratogenesis).Select carcinogen. Any substance which meets one of the following criteria:
(1) It is regulated by Cal/OSHA as a carcinogen; or(2) It is listed under the category, "known to be carcinogens," in the Annual
Report on Carcinogens published by the National Toxicology Program (NTP) (1985 edition); or
(3) It is listed under Group 1 ("carcinogenic to humans") by the International Agency for Research on Cancer Monographs (IARC) (Volumes 1-48 and Supplements 1-8); or
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§5191. Title 8, CCR
(4) It is listed in either Group 2A or 2B by IARC or under the category, "reasonably anticipated to be carcinogens" by NTP, and causes statistically significant tumor incidence in experimental animals in accordance with any of the following criteria:
(A) After inhalation exposure of 6-7 hours per day, 5 days per week, for a significant portion of a lifetime to dosages of less than 10 mg/m 3 ;
(B) After repeated skin application of less than 300 mg/kg of body weight per week; or
(C) After oral dosages of less than 50 mg/kg of body weight per day.Unstable (reactive). A chemical which is the pure state, or as produced or transported, will vigorously polymerize, decompose, condense, or will become self-reactive under conditions of shocks, pressure or temperature.Water-reactive. A chemical that reacts with water to release a gas that is either flammable or presents a health hazard.
(c) Exposure limits. For laboratory uses of Cal/OSHA regulated substances, the employer shall ensure that laboratory employees' exposures to such substances do not exceed the exposure limits specified in Title 8, California Code of Regulations, Group 16, Section 5139 et seq., of the General Industry Safety Orders.
(d) Employee exposure determination(1) Initial monitoring. The employer shall measure the employee's exposure
to any substance regulated by a standard which requires monitoring if there is reason to believe that exposure levels for that substance exceed the action level (or in the absence of an action level, the exposure limit). The person supervising, directing or evaluating the monitoring shall be competent in industrial hygiene practice.
(2) Periodic monitoring. If the initial monitoring prescribed by subsection 5191(d)(1) discloses employee exposure over the action level (or in the absence of an action level, the exposure limit), the employer shall immediately comply with the exposure monitoring provisions of the relevant regulation.
(3) Termination of monitoring. Monitoring may be terminated in accordance with the relevant regulation.
(4) Employee notification of monitoring results. The employer shall, within 15 working days after the receipt of any monitoring results, notify the employee of these results in writing either individually or by posting results in an appropriate location that is accessible to employees.
(e) Chemical hygiene plan.(1) Where hazardous chemicals as defined by this regulation are used in the
workplace, the employer shall develop and carry out the provisions of a written Chemical Hygiene Plan which is:
(A) Capable of protecting employees from health hazards associated with hazardous chemicals in that laboratory and
(B) Capable of keeping exposures below the limits specified in subsection 5191(c).
(2) The Chemical Hygiene Plan shall be readily available to employees. employee representatives and, upon request, to the Chief.
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§5191. Title 8, CCR
(3) The Chemical Hygiene Plan shall include each of the following elements and shall indicate specific measures that the employer will take to ensure laboratory employee protection;
(A) Standard operating procedures relevant to safety and health considerations to be followed when laboratory work involves the use of hazardous chemicals:
(B) Criteria that the employer will use to determine and implement control measures to reduce employee exposure to hazardous chemicals including engineering controls, the use of personal protective equipment and hygiene practices; particular attention shall be given to the selection of control measures for chemicals that are known to be extremely hazardous;
(C) A requirement that fume hoods comply with Section 5154.1, that all protective equipment shall function properly and that specific measures shall be taken to ensure proper and adequate performance of such equipment;
(D) Provisions for employee information and training as prescribed in subsection 5191(f);
(E) The circumstances under which a particular laboratory operation, procedure or activity shall require prior approval from the employer or the employer's designee before implementation;
(F) Provisions for medical consultation and medical examinations in accordance with subsection 5191(g);
(G) Designation of personnel responsible for implementation of the Chemical Hygiene Plan including the assignment of a Chemical Hygiene officer and, if appropriate, establishment of a Chemical Hygiene Committee; and
(H) Provisions for additional employee protection for work with particularly hazardous substances. These include "select carcinogens," reproductive toxins and substances which have a high degree of acute toxicity. Specific consideration shall be given to the following provisions which shall be included where appropriate;
1. Establishment of a designated area;2. Use of containment devices such as fume hoods or glove boxes;3. Procedures for safe removal of contaminated waste; and4. Decontamination procedures.(4) The employer shall review and evaluate the effectiveness of the Chemical
Hygiene Plan at least annually and update it as necessary.Appendix A of this section is non-mandatory but provides guidance to assist employers in the development of the Chemical Hygiene Plan.
(f) Employee information and training.(1) The employer shall provide employees with information and training to
ensure that they are apprised of the hazards of chemicals present in their work area. Information and training may relate to an entire class of hazardous substances to the extent appropriate.
(2) Such information shall be provided at the time of an employee's initial assignment to a work area where hazardous chemicals are present and prior to
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§5191. Title 8, CCR
assignments involving new exposure situations. The frequency of refresher information and training shall be determined by the employer.
(3) Information. Employees shall be informed of:(A) The contents of this regulation and its appendices which shall be
available to employees;(B) The location and availability of the employer's Chemical Hygiene Plan;(C) The exposure limits for Cal/OSHA regulated substances or recommended
exposure limits for other hazardous chemicals where there is no applicable Cal/OSHA regulation;
(D) Signs and symptoms associated with exposures to hazardous chemicals used in the laboratory; and
(E) The location and availability of known reference material on the hazards, safe handling, storage and disposal of hazardous chemicals found in the laboratory including, but not limited to, Material Safety Data Sheets received from the chemical supplier.
(4) Training.(A) Employee training shall include;1. Methods and observations that may be used to detect the presence or
release of a hazardous chemical (such as monitoring conducted by the employer, continuous monitoring devices, visual appearance or odor of hazardous chemicals when being released, etc.);
2. The physical and health hazards of chemicals in the work area; and3. The measures employees can take to protect themselves from these
hazards, including specific procedures the employer has implemented to protect employees from exposure to hazardous chemicals, such as appropriate work practices, emergency procedures, and personal protective equipment to be used.
(B) The employee shall be trained on the applicable details of the employer's written Chemical Hygiene Plan.
(g) Medical consultation and medical examinations.(1) The employer shall provide all employees who work with hazardous
chemicals an opportunity to receive medical attention, including any follow-up examinations which the examining physician determines to be necessary, under the following circumstances;
(A) Whenever an employee develops signs or symptoms associated with a hazardous chemical to which the employee may have been exposed in the laboratory, the employee shall be provided an opportunity to receive an appropriate medical examination.
(B) Where exposure monitoring reveals an exposure level above the action level (or in the absence of an action level, the exposure limit) for a Cal/OSHA regulated substance for which there are exposure monitoring and medical surveillance requirements, medical surveillance shall be established for the affected employee as prescribed by the particular standard.
(C) Whenever an event takes place in the work area such as a spill, leak, explosion or other occurrence resulting in the likelihood of a hazardous exposure, the affected employee shall be provided an opportunity for a medical consultation. Such consultation shall be for the purpose of determining the need for a medical examination.
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§5191. Title 8, CCR
(2) All medical examinations and consultations shall be performed by or under the direct supervision of a licensed physician and shall be provided without cost to the employee, without loss of pay and at a reasonable time and place.
(3) Information provided to the physician. The employer shall provide the following information to the physician;
(A) The identity of the hazardous chemical(s) to which the employee may have been exposed;
(B) A description of the conditions under which the exposure occurred including quantitative exposure data, if available; and
(C) A description of the signs and symptoms of exposure that the employee is experiencing, if any.
(4) Physician's written opinion.(A) For examination or consultation required under this standard, the
employer shall obtain a written opinion from the examining physician which shall include the following;
1. Any recommendation for further medical follow-up;2. The results of the medical examination and any associated tests, if
requested by the employee;3. Any medical condition which may be revealed in the course of the
examination which may place the employee at increased risk as a result of exposure to a hazardous chemical found in the workplace; and
4. A statement that the employee has been informed by the physician of the results of the consultation or medical examination and any medical condition that may require further examination or treatment.
(B) The written opinion shall not reveal specific findings of diagnoses unrelated to occupational exposure.
(h) Hazard identification.(1) With respect to labels and material safety data sheets;(A) Employers shall ensure that labels on incoming containers of hazardous
chemicals are not removed or defaced.(B) Employers shall maintain in the workplace any material safety data
sheets that are received with incoming shipments of hazardous chemicals, and ensure that they are readily accessible to laboratory employees during each work shift when they are in their work area(s).
(2) The following provisions shall apply to chemical substances developed in the laboratory;
(A) If the composition of the chemical substance which is produced exclusively for the laboratory's use is known, the employer shall determine if it is a hazardous chemical as defined in subsection 5191(b). If the chemical is determined to be hazardous, the employer shall provide appropriate training as required under subsection 5191(f).
(B) If the chemical produced is a byproduct whose composition is not known, the employer shall assume that the substance is hazardous and shall implement subsection 5191(e).
45
§5191. Title 8, CCR
(C) If the chemical substance is produced for commercial purposes by another user outside of the laboratory, the employer shall comply with the Hazard Communication Standard (Section 5194) including the requirements for preparation of material safety data sheets and labeling.
(i) Use of respirators.Where the use of respirators is necessary to maintain exposure below
permissible exposure limits, the employer shall provide, at no cost to the employee, the proper respiratory equipment. Respirators shall be selected and used in accordance with the requirements of Section 5144.
(j) Record keeping.(1) The employer shall establish and maintain for each employee an accurate
record of any measurements taken to monitor employee exposures and any medical consultation and examinations including tests or written opinions required by this regulation.
(2) The employer shall ensure that such records are kept, transferred, and made available in accordance with Section 3204.
(k) Dates(1) Employers shall have developed and implemented a written Chemical
Hygiene Plan no later than October 31, 1991.(2) Subsection (a) (2) shall not take effect until the employer has developed
and implemented a written Chemical Hygiene Plan.( l ) Appendices. The information contained in the appendices is not intended, by itself, to create any additional obligations not otherwise imposed or to detract from any existing obligation. Note: Authority cited: Sections 142.3 and 9020, Labor Code. Reference: Sections 142.3, 9004(d), 9009 and 9020, Labor Code.
History 1. New section filed 3-25-91; operative 4-24-91 (Register 91, No. 17).
2. Editorial correction of printing errors (Register 92, No. 33).
3. Change without regulatory effect amending Appendix B subsections (b)1. and (c)1. filed 12-28-92 pursuant to section 100, title 1, California Code of Regulations (Register 93, No. 1).
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APPENDIX B
Laboratory Safety Inspection Checklist
47
LABORATORY SAFETY INSPECTION CHECKLISTPage 1
This form is consistent with current governmental regulations. However, the regulations are subject to interpretation by individual inspectors. This form shall be used as a guideline for performing a laboratory inspection; it is not intended to bring a lab into full compliance.
The design of the form is to identify areas that need improvement with respect to regulatory compliance. “Y” answers indicate a satisfactory situation, while “N” indicates an area that needs improvement. These areas can then be prioritized in order of severity. “N/A” indicates a not applicable situation.
Building #:________
Room #:______ Date:____________ Time:_______
Principal Investigator:___________________________
Department:__________________________
Survey Conducted By:______________________________________________________________
Y - Satisfactory N - Needs Improvement N/A - Not ApplicableY N N/A
HAZARDOUS MATERIALS
1. DOCUMENT AVAILABILITY a. Chemical inventory is complete, current and readily accessible to employees at a central location.
Location: ______________________________________b. MSDSs are on file in department and readily accessible to employees.
Location:_______________________________________c. The CSPL is readily available in the laboratory, and the Standard Operating Procedures for this
specific laboratory are attached.d. In the case of teaching laboratories, the CSPL and SOPs are filed in the department office.e. If applicable, a current Prior Approval Form signed by the Department Chairperson is readily
available in the laboratory.
2. LABELINGa. Containers of stock solutions properly identified (e.g. buffers labeled and marked with the words
"buffer"). b. Original product names (or full chemical names) and hazards (health and physical hazards)
clearly identified on labels. This includes those in fume hoods and bio-safety cabinets. c. Containers of non-hazardous substances (e.g., water) labeled explicitly to avoid confusion. d. Synthesized, unnamed chemicals labeled by their reactants and possible products (or by a useful
generic description) and with their probable hazards (health and physical hazards). e. All containers such as vats and storage tanks labeled as to their contents.
3. CONTROL a. Designated area established for the use of particularly hazard substances, including "select
carcinogens," reproductive toxins and substances which have a high degree of acute toxicity. . b. Incompatible chemicals segregated by chemical physical class. c. Infectious waste placed in closed, leak-proof containers, bags or puncture-resistant holders with
proper labels. d. Containers of peroxide-forming chemicals are dated upon receipt and disposed of within
manufacturer's suggested expiration dates (shelf life).
48
e. Secondary containment provided, as required.
49
LABORATORY SAFETY INSPECTION CHECKLISTPage 2
Y - Satisfactory N - Needs Improvement N/A - Not ApplicableY N N/A
HAZARDOUS MATERIALS (cont’d)
3. CONTROL (cont'd)f. All chemical containers capped and sealed, except when actively adding or removing materials
from them. g. No disposal of chemicals by evaporation into a fume hood.
4. STORAGE OF FLAMMABLE /COMBUSTIBLE LIQUIDSa. Liquids not dispensed from gravity-fed or bottom-dispensing containers (use lid-mounted
pumps). b. Approved containers and tanks used for the storage and handling of flammable and combustible
liquids.c. Flammable liquid storage cabinet(s) used and adequate for needs d. Flammable liquids in quantities in excess of 10 gallons are stored in a flammable liquid storage
cabinet with self-closing door.e. All flammable liquid cabinets are free of combustible materials (cardboard, paper, etc.) f. Approved metal safety cans are limited to 5 gallons maximum. g. Flammable liquids in excess of one day's operational supply kept in approved flammable
cabinets.h. Storage areas for hazardous substances are properly segregated to ensure that incompatible
chemicals are not kept together (e.g., corrosives not stored with flammables). i. Bulk drums of flammable liquids grounded and bonded to containers during dispensing. j. All flammable liquids kept in closed containers when not in use (e.g. parts cleaning tanks, pans). k. Storage rooms for flammable and combustible liquids have explosion-proof lights.l. Storage rooms for flammable and combustible liquids have mechanical or gravity ventilation.m. Fire separators placed between containers of combustibles or flammables, when stacked one
upon another, to assure their support and stability.n. Ether and other highly-flammable liquids are stored away from sources of heat and ignition.
HAZARDOUS WASTE
1. CONTAINMENT AND STORAGEa. Waste is contained according to the campus hazardous waste management Policy and Procedures
Manual. b. Specific storage containers provided for (check applicable categories): chemical wastes ( ); recyclable solvents ( ); radioactive waste ( ); bio-hazardous wastes ( ); sharps
( ); mixed wastes ( ).c. Waste containers are sturdy, routinely inspected for leaks, compatible with the waste, and kept
closed when hazardous waste is not being added or removed.d. Incompatible wastes are not stored together.e. Not stored for more than 90 days from the initial date of accumulation.f.. Records kept of waste pick-up requests, including date contacted and date picked up.
2. CHEMICAL WASTE LABELINGa. Containers are labeled with the initial date of accumulation, with the words "Hazardous Waste,"
with the waste's physical state and hazard class (e.g. flammable), with full product names, with appropriate percentages, and with the EH&S tracking number.
b. EH&S waste tracking forms are available and used on all hazardous waste containers. c. Synthesized, unnamed chemical wastes labeled by their reactants and possible products (or by a
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useful generic description) and with their probable hazards (physical and health hazards).
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LABORATORY SAFETY INSPECTION CHECKLISTPage 3
Y - Satisfactory N - Needs Improvement N/A - Not ApplicableY N N/A
HAZARDOUS WASTE (cont’d)
3. BIOHAZARDOUS WASTESa. Contained in red bags that are labeled as bio-hazardous waste. b. Syringes/needles and other sharps disposed of in sharps containers and emptied regularly
(weekly). c. All infectious waste bags are red in color. d. Animal carcasses and/or infectious tissues are properly contained and disposed of.
HEALTH AND SAFETY TRAINING
1. TRAINING OCCURS:a. When an employee or student first begins work.b. When an employee or student is given a new assignment for which training has not previously
been received.c. Whenever new hazards are introduced into the workplace by new substances, processes or
equipment.d. Whenever the supervisor is made aware of a new or previously unrecognized hazard.
2. EMPLOYEES TRAINED ON: a. The University's Hazard Communication Program.b. The University's Chemical Safety Plan for Laboratories.c. The applicable laboratory-specific Standard Operating Procedures.d. Any supplemental procedures listed on a Prior Approval Form for this laboratory.e. Information concerning safety administration, programs, and procedures applicable to the
college, department or building. f. Employees are periodically instructed in the use of fire extinguishers.
RECORD KEEPING
a. Records of employee and student participation in safety and health training are maintained (retain records for duration of employment).
b. Documentation is complete for safety training classes and other training situations (e.g. one-on-one).
c. Documentation of safety inspections and corrections maintained.d. Carcinogen use reports filed with Cal/OSHA as required.e. Chemical Safety Committee meeting records maintained.f. A file of departmental Standard Operating Procedures is maintained by the DSC.g. A central departmental file is maintained for Prior Approval Forms signed by Chairperson.
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LABORATORY SAFETY INSPECTION CHECKLISTPage 4
Y - Satisfactory N - Needs Improvement N/A - Not ApplicableY N N/A
HEALTH AND SAFETY EQUIPMENT
1. SAFETY SHOWERS AND EYE WASHES a. Approved safety showers and eye washes provided within the work area for immediate use
(within 10-15 seconds of exposure) and with access to them unobstructed.b. Safety showers and eye washes are unobstructed.c. Safety showers and eye washes are inspected and maintained regularly to ensure proper
operation.
2. LABORATORY FUME HOODS a. Certified (air flow check) within the last year.b. Air flow indicator present and operating properly.c. Storage within the hood minimized and containers kept sealed.d. Front sash is lowered to appropriate level when hood is in use (sticker is in place to indicate sash
height).
3. BIOLOGICAL SAFETY CABINETS (e.g., Laminar flow hoods)a. Tested and certified within last year.b. Proper type of work being conducted in cabinet.
4. COMPRESSED GAS CYLINDER SAFETYa. Cylinders protected from external heat sources and stored in well-protected, well-vented, dry
locations away from highly combustible materials.b. Storage space will not be damaged by passing or falling objects and not subject to tampering by
unauthorized persons. c. Secured to a structural component of the building with chains at 2/3 and l/3 of the cylinder height. d. Protective caps in place while the cylinders are not in use or connected for use.e. Only chemically compatible cylinders stored together. f. Cylinder contents adequately identified on a label that can easily be seen.
5. HOUSEKEEPING AND MISCELLANEOUS LABORATORY SAFETYa. Damaged or malfunctioning equipment is tagged out of service.b. All work areas (bench tops, office/desk areas) are kept clean and organized and environment
maintained to eliminate harmful exposures or unsafe conditions.c. Vacuum lines are equipped with traps designed specifically to accumulate/filter the hazardous
materials being evacuated.d. All vacuum pump belts adequately protected by a rigid belt guard or housing. e. Extension cords not used as permanent wiring and no equipment has frayed electrical cords.f. High voltage equipment (greater than 600 V) labeled, grounded, and insulated.
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LABORATORY SAFETY INSPECTION CHECKLISTPage 5
Y - Satisfactory N - Needs Improvement N/A - Not ApplicableY N N/A
HEALTH AND SAFETY EQUIPMENT (cont’d)
6. PERSONAL PROTECTIVE EQUIPMENT (PPE) USED AND REQUIRED IN LAB(Check applicable categories)
( ) Safety glasses/goggles/face shields ( ) Lab coats/aprons ( ) Gloves( ) Respiratory protection ( ) No open-toe footwear ( ) PPE for radiological work
a. When not in use, is personal protective equipment properly maintained/stored?b. Are areas requiring use of protective equipment adequately posted and enforced? c. Respiratory protection use conforms to the university "Respiratory Protection Program".d. Respirators are stored in a way that avoids exposure to excessive heat, dust and chemicals.
EMERGENCY PREPAREDNESS
1. BASIC EARTHQUAKE SAFETYa. Shelves have lips or other seismic restraints.b. Cabinets and bookshelves are secured to walls.c. Computers secured to desks, bench tops. d. Overhead storage is minimized and restrained from falling. e. Emergency action and fire prevention plans available.
2. CONTINGENCY PLANNING AND EMERGENCY PROCEDURESa. Chemical spill kit/cleanup materials provided.b. Training in spill clean-up procedures provided and documented.
3. FIRST AID MATERIALS a. kept in adequate supply. b. kept in sanitary and usable condition. c. are made readily available.
4. FIRE PREVENTION AND ELECTRICAL SAFETYa. Appropriate fire extinguisher available (unobstructed) within 75 feet and inspected within the last
year. b. Fire extinguishers mounted and clearly visible.c. 18 inch vertical clearance maintained from sprinkler heads (e.g., over shelves or equipment).
5. EXITS AND WIDTH OF EXITSa. Exits and aisles are clear and free of potential obstructions in case of emergency.b. Exit signs are posted to clearly indicate exits.c. Width of exit aisles and pathways not less than 28 inches.
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LABORATORY SAFETY INSPECTION CHECKLISTPage 6
Y - Satisfactory N - Needs Improvement N/A - Not ApplicableY N N/A
EMERGENCY PREPAREDNESS (cont’d)
6. ELECTRICAL a. At least 30 inches of clearance in front of electrical panels/breaker boxes.b. Electric hand tools are properly grounded/double insulated.c. Electric cords are insulated and free from damage/fraying.d. Circuit breaker panels are free of combustible materials.
EMPLOYEE EXPOSURE
a. Employee exposure to chemicals is monitored and kept within acceptable levels (below regulated limits).
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APPENDIX C
Hazard Communication Program Summary
56
HAZARD COMMUNICATION PROGRAM SUMMARY
The information below provides a summary of the provisions under the Hazard Communication Program (HCP). For specific details concerning the HCP refer to the Cal Poly Hazard Communication Program Manual.
Departments shall ensure that each employee receives information and training on hazardous substances in his/her work area at the time of initial assignment, whenever a new potential hazard is introduced into the work area, or when an employee is given a new job or task assignment for which no previous training has been provided. The Environmental Health and Safety Department will provide general Hazard Communication Training.
Departments shall furnish employees with general information about the purpose of an MSDS as well as specific information concerning the contents of the MSDS for any hazardous substance to which the employees are exposed.
When training employees who may be exposed to hazardous substances, the department shall ensure that each of the following hazard communication training requirements are covered:
a. Each department shall ensure the following information is explained as outlined in the MSDS: 1. Any health hazards associated with the use of this substance or
mixture; 2. Proper precautions for handling, necessary personal protective
equipment, and other safety precautions necessary to minimize or prevent exposure to the hazardous substance;
3. Emergency procedures for fire, spills, disposal, and first aid. The information may relate to an entire class of hazardous substances to the extent appropriate and related to the job.
4. Significant revisions in the MSDS shall be provided to all employees.
b. Each department shall inform employees of their right: 1. To personally receive information regarding hazardous substances
to which they may be exposed; 2. For their physician or collective bargaining agent to receive such
information; 3. To be protected from dismissal or other discrimination due to the
employee's exercise of their rights afforded by this law. c. Departments shall ensure employees are informed of:
1. Requirements of the HCP; 2. Any operations in their work area where hazardous substances
are present; 3. Location and availability of the written HCP.
d. Departments shall ensure that employees are trained in: 1. Methods and observations that may be used to detect the
presence or release of hazardous substances in the work area.
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2. Physical and health hazards of the substances in the work area and the measures they can take to protect themselves from these hazard; These measures shall include specific procedures the department has implemented to protect employees from exposure to hazardous substances.
3. Details of the HCP including an explanation of the labeling system, the MSDS, and how employees can obtain and use the appropriate hazard information.
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APPENDIX D
Training Documentation Form
59
TRAINING DOCUMENTATION FORM
Name of Trainer:_________________________________ Dept._____________ Date:___________
Subjects Covered:_______________________________________________________________________________________________________________________________________________________________________________________________________________________________
Type of Training: ______________________ Initial____ Refresher____ Total Time: ______hours
Handouts Provided:________________________________________________________________
ATTENDEESPrint Name Signature
Distribution of Copies: Department Office, DSC, EH&S, Training Provider
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APPENDIX E
Chemical Donation Procedure
61
CHEMICAL DONATION PROCEDURE
Due to regulatory requirements and escalating disposal costs, this procedure for chemical donations applies to all Departments which accept chemical donations regulated by Federal, State, and local agencies. The Environmental Health and Safety Department will assist in the donation process by providing information on legal requirements and estimates of potential costs associated with proposed donations.The following are the procedures to be followed:
1. Donations of hazardous chemicals must receive clearance in advance by the Dean or Director, Manager, and the Environmental Health and Safety Department (see attached form).
2. All chemicals accepted must be in sealed, unopened, undamaged, and properly labeled original containers (manufacturer’s label is usually the best certification that the contents are accurately identified).
3. Material Safety Data Sheets (MSDSs) must be obtained for all donated materials before the materials are brought onto campus. The MSDS must be provided to the Environmental Health and Safety Department as part of the approval process.
4. Delivery of the donations must adhere to all DOT regulations relating to the transportation of hazardous materials (which include chemical materials). If the donation quantities are large amounts (5 gal. or more) or if they are “extremely hazardous,” radioactive, or FDA regulated substances, special transportation, packaging, or labeling may be required. The EH&S Department must be contacted prior to pickup/delivery of any donated chemicals, without exception.
5. Complete inventories of all materials received shall be provided to the EH&S Department to insure campus inventory update requirements in accordance with Business Plan regulations (Chapter 6.95, California Health and Safety Code). Inventories must be provided as part of the approval process in advance of taking possession of the donated materials.
6. Certain donated chemicals and regulated materials may be subject to special disposal requirements or limitations which may result in costly disposal fees.
7. The following Chemical Donation Form and abbreviations must be used when accepting or donating chemicals.
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63
APPENDIX F
Chemical Donation Form
64
CHEMICAL DONATION FORMAbbreviations
The abbreviations presented below must be used on the Chemical Donation Form. All mixtures must identify the chemical compounds in the mixture and the corresponding concentrations. Examples are provided on the first few lines on the attached Form.
Unit Values Container TypePhysical
StateDOT Classification
(Hazard Class- list all that apply)
L - liters C - Can G - Gas Class-1 Explosivesml - milliliters
CY - Cylinder L - Liquid Class-2 Compressed Gasses
gal - gallons DM - Metal Drum S - Solid Class-3 Flammable liquidscf - cubic feet
DF - Fiber/Plastic Drum Class-4 Flammable Solids
g - grams CM - Metal Box/Container Class-5 Oxidizersoz - ounces CF - Fiber/Plastic Box
/ContainerClass-6 Poisons
kg - kilograms
CW - Wood Box/Container Class-7 Radioactive Material
lb - pounds BA - Bag Class-8 Corrosive MaterialBG - Bottle Glass Class-9 Misc. Dangerous
MaterialBF - Bottle Fiber/Plastic
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CHEMICAL DONATION FORM
Name:________________________________ Department:____________________________Date:_____________ Time:_____________ Building:__________ Room:____________
Aisle:_____________ Shelf:_____________
Location
Chemical NameConcentration Mixture (%)
Container
Type
ContainerQuantity
Units Per Container
Total Units
Physical State
003-201
Hydrofluoric Acid 97 BG 2 2.5 L 3 L
044-002
NitroxOxygen 35 Nitrogen 65 CY 2 80 cf 160 cf
003-132
Borax (Soap) 25 CF 3 1.5 lb. 3.5 lb.
* Location - Building and Room Number
Proposed Method of Shipment/Delivery:____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________
Reviewed by DSC Department Safety Coordinator:________________________________________________________________
Approve DisapproveDepartment Chair/Manager:___________________________________________________________________
Approve DisapproveDean/Director:_____________________________________________________________________________
Approve DisapproveEH&S Office:______________________________________________________________________________
Comments:__________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________
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APPENDIX G
Standard Operating Procedures & Prior Approval Form
67
Standard Operating Procedures & Prior Approval Form(page 1 of 3)
INSTRUCTIONS: COMPLETE THIS PAGE AND PART I AND/OR PART II, AS APPLICABLE
Indicate with a check () which of the following apply:[ ] SOP Submission Only- prior approval from Department Chair is not required for this experiment. [ ] Both SOP Submission and Application for Prior Approval- complete both Parts I & II of this form.[ ] Prior Approval Only- SOP is already on file (complete Part II and attach a copy of the SOP).
Prepared by: ______________________________________ Dept.______________ Date: _________Check () One: [ ] Principal Investigator; [ ] Course Instructor; [ ] Lead Technician
Name of the Specific Experiment or Process: _____________________________________________
For instructional laboratory: Title of Course ____________________________________________For research laboratory: Name of Research Project _______________________________________
Laboratory Location: Bldg. ____________; Room _______
If applicable: Location in Room: ______________________________________________________(in situations where the same room is divided into several research areas)
If applicable: Day of week _________________ ; time of day ___________(in situations where the same work area is utilized by another instructor or investigator at another time)
Distribution:a. If submitting only a Standard Operating Procedures Form:
Send original to DSC with copy to Department Office; keep a copy in the room where the experiment or process will take place.
b. If this submission contains an Application for Prior Approval:Submit all paperwork to Dept. Chair (or, depending on department policy, to the DSC for preliminary review); after approval, keep a copy with the Chair's signature in the laboratory.
Training and Documentation:Principal investigators, course instructors and lead technicians must ensure that SOPs and any additional precautions listed on an Application for Prior Approval have been explained to and understood by the workers/students under their control. Maintain written documentation showing that this training has taken place.
Department Tracking Information: ____________________________________EH&S Tracking Information: _______________________________________
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PART I: STANDARD OPERATING PROCEDURES (SOP&PA page 2 of 3)
List the hazardous chemical(s) which will be used and the class* of each chemical. Include information about hazardous byproducts: ___________________________________________________________________________________________________________________________________________________________________________________________________________________________________
Describe the process: __________________________________________________________________ ____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________
Describe the methods laboratory workers shall use to minimize the health and safety risks associated with the hazardous chemicals. (circle all that apply and add details as necessary)a. personal protective equipment: goggles - face shield - gloves - protective apparel - shoes - respiratorb. engineering controls: fume hood - snorkel - glove box________________________________________________________________________________________________________________________________________________________________________
Indicate any special chemical storage procedures:____________________________________________ ____________________________________________________________________________________
List equipment which will be available in case of a spill or accident(circle all that apply and add details as necessary): Eyewash - shower - fire extinguisher - spill control materials - first aid kit____________________________________________________________________________________
Describe emergency procedures for spills or accidents: _______________________________________________________________________________________________________________________________________________________________________________________________________________
Discuss steps you will take to minimize the amount of waste created: ____________________________________________________________________________________________________________________________________________________________________________________________________
Discuss waste disposal: ____________________________________________________________________________________________________________________________________________________
Is prior approval to be obtained by laboratory workers who are assisting on the project? YES - NOIf "YES," please provide details in the following questions:a. Indicate whether prior approval is required for the experiment as a whole: YES - NOb. Indicate whether prior approval is required for certain aspects of the experiment or in certain circumstances: YES - NO If yes, give details ___________________________________________c. If answer to either (a) or (b) is "yes," who is authorized to give prior approval (check one)? [ ] person listed in at top of page one; or [ ] another person (specify) __________________________
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* SUGGESTED ABBREVIATIONS OF HAZARD CLASSES: Explosion- E; Compressed Gas- CG; Flammable- F; Oxidizer- Ox; Toxic- T; Infectious- I; Radioactive- RA; Corrosive- CPART II: PRIOR APPROVAL FROM DEPARTMENT CHAIR (SOP&PA page 3 of 3)
(submit this section only when there are special circumstances which require prior approval)
REASON PRIOR APPROVAL IS REQUIRED (check () all that apply):[ ] A. Work will take place outside normal operating hours.[ ] B. Experiments will involve one person working alone. (Note: such permission is seldom granted.)[ ] C. Experiments will be running at times when nobody is present in the laboratory.[ ] D. Experiment involves the use of a particularly hazardous substance.
If you have checked A, B, or C:
Describe special precautions which will be taken: ____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________
If you have checked box D (Particularly Hazardous Substances), discuss all of the following:
a. Describe the establishment of a designated area: _______________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________
b. Describe special decontamination procedures: __________________________________________________________________________________________________________________________________________________________________________________________________________________
c. Describe procedure to handle particularly hazardous waste: ________________________________________________________________________________________________________________________________________________________________________________________________________
SIGNATURE OF APPLICANT __________________________________ Date ____________- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Preliminary Review by Dept. Safety Coordinator (optional, depending on department policy):Comments:___________________________________________________________________Signature of DSC _____________________________________ Date ___________
Action by Dept. Chair: Approve [ ] Deny [ ] Comments:_______________________________________________________________________________________________________________Signature of Dept. Chair ______________________________________ Date ___________
Approval expires on:_____________________ (approvals granted for maximum of three months)
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Distribution: Dept. Chair will sign and send copies to the DSC, EH&S, and applicant.
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APPENDIX H
Permissible Exposure Limits for Chemical Contaminants
California Code of Regulations, Title 8, Section 5155, Table AC-1
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
75070 Acetaldehyde 25 45 C64197 Acetic acid 10 25 40 ppm 15 37108247 Acetic Anhydride 5 20 C67641 Acetone 500 1200 3000 ppm 750 178075868 Acetone cyanohydrin as CN 4.7 5 C75058 S Acetonitrile 40 70 60 10598862 Acetophenone 10 4953963 S 2-Acetylaminofluorene; N-fluoren-2-yl
acetamide; see Section 520974862 Acetylene (h)540590 Acetylene dichloride; see 1,2-
Dichloroethylene79276 Acetylene tetrabromide:1,1,2,2-
tetrabromoethane1 14
79345 Acetylene tetrachloride; see 1,1,2,2-Tetrachloroethane
50782 Acetylsalicylic acid (Aspirin) 5107028 S Acrolein 0.1 0.25 C79061 S Acrylamide -- 0.0379107 S Acrylic acid 2 5.9107131 S Acrylonitrile; see Section 5213 2 4.5124049 Adipic acid -- 5111693 S Adiponitrile 2 8.8309002 S Aldrin; 1,2,3,4,10,10-hexachloro-
1,4,4a,5,8,8a-hexahydro-endo-1,2-exo-5,8-dimethanonaphthalene
-- 0.25
107186 S Allyl alcohol 0.5 1.25 4 10107051 Allyl chloride 1 3 2 6106923 S Allyl glycidyl ether; AGE 5 22 10 442179591 Allyl propyl disulfide 2 12 3 181344281 Alumina; see Particulates not otherwise
regulatedAluminum, alkyls (not otherwise classified) -- 2Aluminum soluble salts -- 2Aluminum metal and oxide Total dust -- 10Aluminum metal and oxide Respirable fraction(n)
-- 5(n)
Aluminum pyro powders -- 5Aluminum welding fumes -- 5
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Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
300925 Aluminum distearate -- 107047849 Aluminum stearate -- 10637127 Aluminum tristearate -- 101300738 Aminodimethylbenzene; see Xylidene92671 S 4-Aminodiphenyl; see Section 5209141435 2-Aminoethanol; see Ethanolamine91598 2-Aminonapthalene; see beta-Naphthylamine,
Section 5209504290 2-Aminopyridine 0.5 261825 Amitrole -- 0.27664417 Ammonia 25 18 35 273825261 S Ammonium perfluorooctanoate -- 0.112125029 Ammonium chloride fume -- 10 -- 201002897 Ammonium stearate -- 107773060 Ammonium sulfamate Total dust -- 107773060 Ammonium sulfamate Respirable fraction(n) -- 5620111 3-Amyl acetate; See Pentyl acetate628637 n-Amyl acetate; See Pentyl acetate626380 sec-Amyl acetate (all isomers and mixtures);
See Pentyl acetate625161 tert-Amyl acetate; See Pentyl acetate62533 S Aniline 2 7.629191524 S Anisidine (ortho and para isomers) 0.1 0.5
Antimony and compounds, as Sb -- 0.586884 ANTU; 1-(1-naphthyl)-2-thiourea; Bantu;
Rattrack-- 0.3
7440371 Argon (h)7440382 Arsenic and inorganic arsenic compounds;
see also Section 52140.01
Arsenic, organic compounds, as As -- 0.27784421 Arsine; AsH3 0.05 0.21332-21-4 Asbestos (including actinolite, amosite
anthophyllite, chrysotile, crocidolite, and tremolite); see Section 5208
0.1 f/cc
8052424 Asphalt (petroleum) fumes -- 51912249 Atrazine -- 586500 S Azinphos methyl; o,o-dimethyl S-(4-oxo-1,2,3-
benzotriazin-3(4H)-ylmethyl) phosphorodithioate
-- 0.2
3333526 S 2,2'-Azobisisobutyronitrile decomposition product, see Tetramethyl succinonitrile
7440393 Barium, soluble compounds, as Ba -- 0.57727437 Barium sulfate; see Particulates not otherwise
regulated17804352 Benomyl Total dust -- 1017804352 Benomyl Respirable fraction(n) -- 571432 S Benzene; see also Section 5218 1 5 --
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Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
92875 S Benzidine; 4,4'-diaminobiphenyl, see Section 5209
71432 Benzol; see Benzene106514 D-Benzoquinone; see Quinone98884 Benzoyl chloride 0.2 1.1 C94360 Benzoyl peroxide; dibenzoyl peroxide -- 5140114 Benzyl acetate 10 61100447 benzyl chloride; alpha-chlorotoluene 1 57440417 Beryllium, and beryllium compounds as Be -- 0.0002 0.025mg/M3 --92524 Biphenyl; diphenyl; phenylbenzene 0.2 1.5542881 Bis(chloromethyl) ether, see bis-Chloromethyl
ether, Section 52093033623 S Bis (Dimethylaminoethyl) ether (DMAEE) 0.05 0.328 0.15 0.9831304821 Bismuth telluride Total dust -- 101304821 Bismuth telluride Respirable fraction(n) -- 5
Bismuth telluride (selenium-doped) -- 5Borates, tetra, sodium salts Anhydrous -- 5Borates, tetra, sodium salts Decahydrate -- 5Borates, tetra, sodium salts Pentahydrate -- 5
1303862 Boron oxide -- 1010294334 Boron tribromide 1 10 C7637072 Boron trifluoride 1 3 C314409 Bromacil 1 107726956 Bromine 0.1 0.7 C7789302 Bromine pentafluoride 0.1 0.774975 Bromochloromethane; see Chlorobromethane74964 Bromoethane; see Ethyl bromide75252 S Bromoform; tribromomethane 0.5 574839 Bromomethane, see Methyl bromide75638 Bromotrifluoromethane; see
Trifluorobromomethane106990 1,3-Butadiene (see also section 5201) 1 2.2 5 11106978 Butane 800 1,900109795 1-Butanethiol; see Butyl mercaptan71363 1-Butanol; see n-Butyl alcohol78933 2-Butanone; see Methyl ethyl ketone111762 S 2-Butoxyethanol (EGBE) 20 97123864 n-Butyl acetate 150 710 200 950105464 sec-Butyl acetate 200 950540885 tert-Butyl acetate 200 950141322 Butyl acrylate 2 1171363 S n-Butyl alcohol; 1-butanol 50 150 C78922 sec-Butyl alcohol 100 30575650 tert-Butyl alcohol 100 300 150 450109739 S Butylamine 5 15 C1189851 S tert-Butyl chromate; di-tert-butyl chromate, as
CrO3 (see also Sections 1532.2, 5206 & 8359)
-- 0.1 C
74
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
1189851 S tert-Butyl chromate; di-tert-butyl as Cr (see also Sections 1532.2, 5206 & 8359)
0.005
1189851 S tert-Butyl chromate; di-tert-butyl2426086 n-Butyl glycidyl ether; BGE; 1-butoxy-2,3-
epoxypropane25 135
138227 n-Butyl lactate 5 25109795 n-Butyl mercaptan 0.5 1.589725 S o-sec-Butylphenol 5 3098511 p-tert-Butyltoluene 1 6.1 20 1207440439 Cadmium metal dust, as Cd (see also
Sections 1532 & 5207)-- 0.005
Cadmium, soluble salts, as Cd (see also Sections 1532 & 5207)
-- 0.005
1306190 Cadmium oxide fume, as Cd (see also Sections 1532 & 5207 )
-- 0.005
7778441 Calcium arsenate; see Arsenic,inorganic (see also Section 5214)
471341 Calcium carbonate; see Particulates not otherwise regulated
--
156627 Calcium cyanamide -- 0.51305620 Calcium hydroxide -- 51305788 Calcium oxide -- 2
Calcium silicate; see Particulates not otherwise regulated
1344952 Calcium silicate (synthetic): see Particulates not otherwise regulated
1592230 Calcium stearate -- 107778189 Calcium sulfate; see Particulates not
otherwise regulated76222 Camphor (synthetic) -- 2105602 Caprolactam dust -- 1 -- 3105602 Caprolactam vapor 5 20 10 402425061 S Captafol -- 0.1133062 Captan -- 563252 Carbaryl; 1-naphthyl N-methylcarbamate -- 51563662 Carbofuran -- 0.11333864 Carbon black -- 3.5124389 Carbon dioxide 5,000 9,000 30,000 54,00075150 S Carbon disulfide 4 12 30 ppm 12 36630080 Carbon monoxide 25 29 200 ppm558134 Carbon tetrabromide 0.1 1.4 0.3 456235 S Carbon tetrachloride 2 12.6 200 ppm 10 6375445 Carbonyl chloride; see Phosgene353504 Carbonyl fluoride 2 5 5 15120809 S Catechol; pyrocatechol 5 209004346 Cellulose (paper fiber); see Particulates not
otherwise regulated21351791 Cesium hydroxide 2
75
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
57749 S Chlordane; 1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
-- 0.5
8001352 S Chlorinated camphene; toxaphene -- 0.5 -- 1Chlorinated diphenyl oxide -- 0.5
7782505 Chlorine 0.5 1.5 1 310049044 Chlorine dioxide 0.1 0.3 0.3 0.97790912 Chlorine trifluoride 0.1 0.4 C107200 Chloroacetaldehyde 1 3 C78955 S Chloroacetone 1 3.8 C532274 alpha-Chloroacetophenone;phenacyl chloride 0.05 0.379049 S Chloroacetyl chloride 0.05 0.2 0.15 0.69108907 Chlorobenzene; monochlorobenzene 10 462698411 S o-Chlorobenzylidene malononitrile; OCBM 0.05 0.4 C74975 Chlorobromomethane; bromochloromethane 200 1,050126998 S 2-Chloro-1,3-butadiene; see Chloroprene75456 Chlorodifluoromethane; Fluorocarbon 22 1,000 3,50053469219 S Chlorodiphenyl (42% chlorine) -- 111097691 S Chlorodiphenyl (54% chlorine) -- 0.5106898 1-Chloro-2,3-epoxypropane; see
Epichlorohydrin75003 Chloroethane; see Ethyl chloride107073 2-Chloroethanol; see Ethylene chlorohydrin75014 Chloroethylene, see Vinyl chloride, Section
521067663 Chloroform; trichloromethane 2 9.7874873 Chloromethane, see Methyl chloride107302 Chloromethyl methyl ether; see Methyl
chloromethyl ether, Section 5209542881 bis-Chloromethyl ether, see also Section 5209 0.001 0.005100005 1-Chloro-4-nitrobenzene; see p-
Nitrochlorobenzene600259 1-Chloro-1-nitropropane 2 1076153 Chloropentafluoroethane 1,000 6,32076062 Chloropicrin; trichloronitromethane 0.1 0.7126998 S Chloroprene; 2-chloro-1,3-butadiene 10 36598787 S 2-Chloropropionic acid 0.1 0.442039874 o-Chlorostyrene 50 285 75 42895498 S o-Chlorotoluene 50 2501929824 2-Chloro-6-(trichloromethyl)pyridine; see
Nitrapyrin2921882 S Chlorpyrifos -- 0.2
Chromite ore processing (chromate), as Cr (see also Sections 1532.2, 5206 & 8359)
-- 0.005
7440473 Chromium metal -- 0.5Chromium (II) compounds, as Cr -- 0.5
76
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
Chromium (III) compounds, as Cr -- 0.5Chromium (VI) compounds, as Cr (see also Sections 1532.2, 5206 & 8359)
-- 0.005 0.1mg/M3
14977618 Chromyl chloride 0.025 0.152971906 Clopidol Total dust -- 10
Clopidol Respirable fraction -- 5Coal (Bituminous) dust <5% quartz, respirable fraction(n)
-- 2
Coal (Bituminous) dust >5% quartz, respirable fraction(n)
-- 0.1
Coal tar pitch volatiles(i) -- 0.27440484 Cobalt, metal fume and dust, as Co -- 0.02
Cobalt carbonyl, as Co -- 0.116842038 Cobalt hydrocarbonyl, as Co -- 0.1
Coke oven emissions, see Section 5211 0.157440508 Copper metal fume, as Cu -- 0.1
Copper salts, dusts and mists, as Cu -- 1Corundum, see Particulates not otherwise regulatedCotton dust, see also Section 5190 -- 1(j)
1319773 S Cresol (all isomers) 5 22123739, 4170303
S Crotonaldehyde; beta-methylacrolein 0.3
299865 Crufomate -- 598828 S Cumene; isopropylbenzene 50 245420042 Cyanamide -- 2
S Cyanide, as CN -- 5460195 Cyanogen 10 20506774 Cyanogen chloride 0.3 0.6 C110827 Cyclohexane 300 1,050108930 S Cyclohexanol 50 200108941 S Cyclohexanone 25 100110838 Cyclohexene 300 1,015108918 S Cyclohexylamine 10 40121824 S Cyclonite; RDX; cyclotrimethylenetrinitramine -- 1.5542927 Cyclopentadiene 75 200287923 Cyclopentane 600 1,72013121705 Cyhexatin; tricyclohexyltin hydroxide 594757 2,4-D;2,4-dichlorophenoxyacetic acid -- 1050293 S DDT; 1,1,1-trichloro-2,2-bis-(p-
chlorophenyl)ethane-- 1
62737 DDVP, see Dichlorvos17702419 S Decaborane 0.05 0.3 0.15 0.98065483 S Demeton; a mixture of o,o-diethyl o-
2(ethylthio)ethyl phosphorothloate and o,o'-diethyl S-2(ethylthio)ethyl phosphorothioate
0.01 0.1
123422 Diacetone alcohol; 4-hydroxy-4-methyl-2-pentanone
50 240
107153 1,2-Diaminoethane; see EthylenediamineDiatomacous earth; see Silica-amorphous
333415 S Diazinon; o,o-diethyl o-(2-isopropyl-6-methyl- -- 0.1
77
4-pyrimidinyl) phosphorothioate
78
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
334883 Diazomethane 0.2 0.494360 Dibenzoyl peroxide; see Benzoyl peroxide19287457 Diborane 0.1 0.12528361 S Dibutyl phenyl phosphate 0.3 3.596128 1,2-Dibromo-3-chloropropane; DBCP; see
Section 52120.001 0.01
75616 Dibromodifluoromethane; see Difluorodibromomethane
106934 S 1,2-Dibromomethane; see Ethylene dibromide, Section 5219
102818 S 2-N-Dibutylaminoethanol 2 14107664 Dibutyl phosphate 1 5 2 1084742 Dibutyl phthalate -- 57572294 Dichloroacetylene 0.1 0.4 C95501 S o-Dichlorobenzene 25 150 50 ppm106467 p-Dichlorobenzene; 1,4-dichlorobenzene 10 60 200 ppm 110 67591941 S 3,3'-Dichlorobenzidine; 4,4'-diamino-3,3'-
dichlorobiphenyl; see Section 5209764410 S 1,4 -Dichloro-2-butene 0.005 0.02575718 Dichlorodifluoromethane 1000 4950 6200 ppm118525 1,3-Dichloro-5,5-dimethyl hydantoin -- 0.2 -- 0.475343 1,1-Dichloroethane 100 400107062 1,2-Dichloroethane, see Ethylene dichloride75354 1,1-Dichloroethylene; see Vinylidene chloride540590 1,2-Dichloroethylene; acetylene dichloride 200 790111444 S Dichloroethyl ether; bis(2-chloroethyl) ether 5 30 10 6075434 Dichlorofluoromethane; Fluorocarbon 21 10 4275092 Dichloromethane; see Methylene chloride594729 1,1-Dichloro-1-nitroethane 2 1078875 1,2-Dichloropropane; see Propylene
dichloride542756 S Dichloropropene 1 575990 2,2-Dichloropropionic acid 1 676142 1,2-Dichlorotetrafluoroethane; Fluorocarbon
1141,000 7,000
62737 S Dichlorvos (DDVP); 2,2-dichlorovinyl dimethyl phosphate
0.1 1
141662 S Dicrotophos -- 0.255124301 Dicyclohexylmethane-4,4'-diisocyanate; see
Methylene bis-(4-cyclohexylisocyanate)77736 Dicyclopentadiene 5 30102545 Dicyclopentadienyl iron Total dust -- 10102545 Dicyclopentadienyl iron Respirable fraction(n) -- 560571 S Dieldrin; 1,2,3,4,10,10-hexachloro-6,7-epoxy-
1,4,4a,5,6,7,8,8a-octahydro-1,4-endo-exo-5,8-dimethanonaphthalene
-- 0.25
111422 S Diethanolamine 0.46 2
79
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
109897 S Diethylamine 5 15 C112367 S Diethylene glycol diethyl ether,Ethyl diglyme 5 33111966 S Diethylene glycol dimethyl ether, Diglyme 1 5.5 5 27100378 S 2-(Diethylamino) ethanol 2 9.6123911 1,4-Diethylene dioxide; see p-Dioxane111400 S Diethylenetriamine 1 460297 Diethyl ether; see Ethyl ether298044 Di-(2-ethylhexyl) phthalate; see Di-sec-octyl
phthalate96220 Diethyl ketone 200 705 300 105784662 Diethyl phthalate -- 575616 Difluorodibromomethane;
dibromodifluoromethane100 860
2238075 Diglycidyl ether; DGE; bis(2,3-epoxypropyl) ether
0.1 0.5
123319 p-Dihydroxybenzene; see Hydroquinone108838 Diisobutyl ketone; 2,6-dimethyl-4-heptanone 25 150108189 S Diisopropylamine 5 20108203 Diisopropyl ether; see Isopryl ether109875 Dimethoxymethane; see Methylal127195 S Dimethylacetamide 10 35124403 Dimethylamine 5 9.2 15 27.660117 4-Dimethylaminoazobenzene, see Section
52091300738 Dimethylaminobenzene; see Xylidene121697 S N,N-Dimethylaniline; dimethylphenylamine 5 25 10 501330207 Dimethylbenzene; see Xylene108849 1,3-Dimethylbutyl acetate; see sec-Hexyl
acetate300765 o,o-Dimethyl o-(1,2-dibromo-2,2-dichloroethyl)
phosphate; see Naled14857342 Dimethylethoxysilane 0.5 2.1 1.5 6.468122 S Dimethylformamide; DMF 10 30108838 2,6-Dimethyl-4-heptanone; see Diisobutyl
ketone57147 S 1,1-Dimethylhydrazine 0.01 0.02567641 Dimethyl ketone; see Acetone62759 N,N-Dimethylnitrosamine; see N-
Nitrosodimethylamine, Section 5209131113 Dimethyl phthalate -- 577781 S Dimethyl sulfate; methyl sulfate 0.1 0.5148016 Dinitolmide; 3,5-Dinitro-o-toluamide -- 5528290, S Dinitrobenzene (all (isomers) 0.15 199650, S Dinitrobenzene ortho and meta isomers 0.15 1100254 S Dinitrobenzene para isomers 0.15 1534521 S 4,6-Dinitro-o-cresol; 2-methyl-4,6-
dinitrophenol-- 0.2
80
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
25321146 S 2,4-Dinitrotoluene -- 0.15123911 S p-Dioxane, tech. grade; 1,4-
dioxacyclohexane; 1,4-diethylene dioxide25 90
78342 S Dioxathion -- 0.292524 Diphenyl; see Biphenyl122394 Diphenylamine; N-phenylaniline -- 10101688 Diphenylmethane diisocyanate; see
Methylene bis(phenylisocyanate)123193 Dipropyl ketone 50 23534590948 S Dipropylene glycol methyl ether 100 600 150 90085007 Diquat; 1,1'-ethylene-2,2'-dipyridinium
dibromide Total dust-- 0.5
85007 Diquat; 1,1'-ethylene-2,2'-dipyridinium dibromide Respirable fraction(n)
117817 Di-sec-octyl phthalate; bis(2 ethylhexyl) phthalate
-- 5 --
97778 Disulfiram -- 2298044 S Disulfoton; o,o-diethyl S-2-(ethylthio)ethyl
phosphorodithioate-- 0.1
128370 2,6-Di-tert-butyl-p-cresol -- 10330541 Diuron -- 1068122 DMF; see Dimethylformamide57147 DMH; see 1,1-Dimethylhydrazine1321740 Divinyl benzene 10 50
Dust, nuisance dust and particulates, see Particulates not otherwise regulated
12415348 Emery; see Particulates not otherwise regulated
115297 S Endosulfan; 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin-3-oxide 8-dimethanonaphthalene
-- 0.1
72208 S Endrin; 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo-5,
-- 0.1
13838169 Enflurane 2 15106898 S Epichlorohydrin; 1-chloro-2,3-epoxypropane 0.05 0.192104645 S EPN; o-ethyl o-(p-nitrophenyl)
phenylphosphonothioate-- 0.1
75569 1,2-Epoxypropane; see Propylene oxide556525 2,3-Epoxypropanol; see Glycidol74840 Ethane (h) --75081 Ethanethiol; see Ethyl mercaptan64175 Ethanol; see Ethyl alcohol141435 Ethanolamine; 2-aminoethanol 3 8 6 15563122 S Ethion -- 0.4110805 S 2-Ethoxyethanol 5 18111159 S 2-Ethoxyethyl acetate 5 27
81
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
141786 Ethyl acetate 400 1,400140885 S Ethyl acrylate 5 20 25 10064175 Ethyl alcohol; ethanol 1,000 1,90075047 S Ethylamine 5 9.2 C541855 Ethyl sec-amyl ketone; 5-methyl-3-heptanone 25 130100414 Ethylbenzene 100 435 125 54574964 S Ethyl bromide 5 22106354 Ethyl butyl ketone; 3-heptanone 50 230 75 34575003 S Ethyl chloride; chloroethane 100 2647085850 Ethyl cyanoacrylate 0.2 1.02673923 Ethyl tert-butyl ether 5 2174851 Ethylene (h) --107073 S Ethylene chlorohydrin; 2-chloroethanol 1 3 C107153 Ethylenediamine; 1,2-diaminoethane 10 25106934 S Ethylene dibromide; 1,2-dibromoethane, see
Section 52190.13 1 C
107062 Ethylene dichloride; 1,2-dichloroethane 1 4 200 ppm 2 8107211 Ethylene glycol (vapor) 40 100 C629141 S Ethylene glycol diethyl ether, 1,2-
diethoxyethane5 24
110714 S Ethylene glycol dimethyl ether,1,2-dimethoxyethane, Glyme
1 3.7 5 18
628966 S Ethylene glycol dinitrate (k) -- 0.1110805 S Ethylene glycol monoethyl ether, see 2-
Ethoxyethanol109864 S Ethylene glycol monomethyl ether, see 2-
Methoxyethanol110496 S Ethylene glycol monomethyl ether acetate;
see 2-Methoxyethyl acetat151564 S Ethyleneimine; see also Section 5209 0.5 175218 Ethylene oxide; see Section 5220 1 2 560297 Ethyl ether 400 1,200 500 1500109944 Ethyl formate 100 30075343 Ethylidene chloride; see 1,1-Dichloroethane16219753 Ethylidene norbornene 5 25 C75081 Ethyl mercaptan; ethanethiol 0.5 178933 Ethyl methyl ketone; see Methyl ethyl ketone100743 S N-Ethylmorpholine; 4-ethyl-1,4-
tetrahydrooxazine5 23
78104 Ethyl silicate; tetraethyl silicate 10 8522224926 S Fenamiphos 0.1115902 Fensulfothion -- 0.155389 S Fenthion -- 0.214484641 Ferbam; ferric N,N-dimethylthiocarbamate -- 1012604589 Ferrovanadium dust -- 1 -- 3
82
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
14808607 Fibrous glass, see GlassFlour dust 0.5(s)
Fluorides, as F -- 2.57782414 Fluorine 0.1 0.275694 Fluorocarbon 11; see Trichlorofluoromethane75718 Fluorocarbon 12; see
Dichlorodifluoromethane75434 Fluorocarbon 21; see Dichlorofluoromethane75456 Fluorocarbon 22; see Chlorodifluoromethane76120 Fluorocarbon 112; see 1,1,2,2-Tetrachloro-
1,2-difluoroethane76131 Fluorocarbon 113; see 1,1,2-Trichloro-1,2,2-
trifluoroethaneFluorocarbon 114; see 1,2-Dichlorotetrafluoroethane
75694 Fluorotrichloromethane; see Trichlorofluoromethane
944229 S Fonofos -- 0.150000 Formaldehyde, see Section 5217 0.75 -- 2 --75127 S Formamide 10 1864186 Formic acid 5 9 10 1998011 S Furfural 2 898000 S Furfuryl alcohol 10 40 15 608006619 Gasoline 300 900 500 15007782652 Germanium tetrahydride 0.2 0.6
Glass, fibrous 1.0 f/cc(q)
111308 Glutaraldehyde (t) 0.05 0.2 C(u)
56815 Glycerin mist; see Particulates not otherwise regulated
123944 Glyceryl stearate -- 10556525 Glycidol; 2,3-epoxy-1-propanol 2 6.1111762 Glycol monobutyl ether; see 2-Butoxyethanol110805 Glycol monoethyl ether; see 2-Ethoxyethanol109864 Glycol monoethyl ether; see 2-
MethoxyethanolGrain dust (oat, wheat, barley) -- 10
7782425 Graphite, natural respirable dust 2.5Graphite, synthetic Total dust -- 10Graphite, synthetic Respirable fraction(n) -- 5
13397245 Gypsum; Calcium sulfate dihydrate; see Particulates not otherwise regulated
7440586 Hafnium -- 0.5151677 Halothane 2 16822060 HDI; see Hexamethylene diisocyanate7440597 Helium (h) --76448 S Heptachlor; 1,4,5,6,7,8,8-hepta-chloro-
3a,4,7,7a-tetrahydro-4,7-methanoindene-- 0.05
142825 n-Heptane 400 1,600 500 2000118741 S Hexachlorobenzene -- 0.00287683 S Hexachlorobutadiene 0.02 0.24
83
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
77474 Hexachlorocyclopentadiene 0.01 0.1167721 S Hexachloroethane; perchloroethane 1 101335871 S Hexachloronaphthalene -- 0.2684162 S Hexafluoroacetone; 1,1,1,3,3,3-hexafluoro-2-
propanone0.1 0.7
822060 Hexamethylene diisocyanate; HDI 0.005 0.034110543 S n-Hexane 50 180
Hexane, other isomers 500 1800 1000 3600124094 1,6-Hexanediamine 0.5 2.3591786 2-Hexanone; see Methyl butyl ketone592416 1-Hexene 50 180108101 Hexone; see Methyl isobutyl ketone108849 sec-Hexyl acetate; 4-methyl-2-pentyl acetate;
1,3-dimethyl-butyl acetate50 300
107415 Hexylene glycol 25 125 C302012 S Hydrazine 0.01 0.01310035106 Hydrobromic acid; see Hydrogen bromide7647010 Hydrochloric acid; see Hydrogen chloride74908 Hydrocyanic acid; see Hydrogen cyanide7664393 Hydrofluoric acid; see Hydrogen fluoride1333740 Hydrogen (h) --61788327 Hydrogenated terphenyls 0.5 510035106 Hydrogen bromide 3 10 C7647010 Hydrogen chloride; muriatic acid 5 7 C74908 S Hydrogen cyanide 4.7 5 C7664393 Hydrogen fluoride, as F 3 2.5 6 --7722841 Hydrogen peroxide, as H2O2 1 1.47783075 Hydrogen selenide, as Se 0.05 0.27783064 Hydrogen sulfide 10 14 50 ppm 15 21123319 Hydroquinone; 1,4-benezendiol -- 2999611 S 2-Hydroxypropyl acrylate 0.5 395136 Indene 10 487440746 Indium -- 0.1
Indium compounds -- 0.17553562 Iodine 0.1 1 C75478 Iodoform 0.6 104098719 IPDI; see Isophorone diisocyanate1309371 Iron oxide fume -- 513463406 Iron pentacarbonyl, as Fe 0.1 0.8 0.2 1.6
Iron salts, soluble, as Fe -- 1123922 Isoamyl acetate; 3-methylbutyl acetate; see
Pentyl acetate123513 Isoamyl alcohol; 3-methylbutanol 100 360 125 450
84
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
110190 Isobutyl acetate; 2-methylpropyl acetate 150 70078831 Isobutyl alcohol; 2-methylpropanol 50 15026675467 Isoflurane 2 1526952216 S Isooctyl alcohol 50 27078591 Isophorone; 3,5,5-trimethyl-2-cyclohexene-1-
one4 23
4098719 S Isophorone diisocyanate; IPDI 0.005 0.045 0.02 --109591 Isopropoxyethanol 25 105108214 Isopropyl acetate 250 950 310 118567630 Isopropyl alcohol 400 980 500 122575310 Isopropylamine 5 12 10 24768525 S N-isopropylaniline 2 10108203 Isopropyl ether; diisopropyl ether 250 1,0504016142 Isopropyl glycidyl ether; IGE; 1,2-epoxy-3-
isopropoxypropane50 240 75 360
1332587 Kaolin; (respirable dust containing no asbestos and <1% crystaline silica)
-- 2
463514 Ketene; ethenone 0.5 0.9 1.5 3Lead arsenate, see Sections 5214 and 5198
7758976 Lead chromate, as Pb (see also Section 5198, 1532.1, 1532.2, 5206 & 8359)
-- 0.02
7758976 Lead chromate, as Cr (see also Section 5198, 1532.1, 1532.2, 5206 & 8359)
-- 0.005
Lead (metallic) and inorganic compounds, dust and fume, as Pb (see also Section 5198 )
-- 0.05
78002 Lead tetraethyl, see Tetraethyl lead75741 Lead tetramethyl, see Tetramethyl lead1317653 Limestone; calcium carbonate; see
Particulates not otherwise regulated58899 S Lindane; 1,2,3,4,5,6-hexachlorocyclohexane,
gamma isomer-- 0.5
7580678 Lithium hydride -- 0.025L.P.G.; liquefied petroleum gas 1,000 1,800
4485125 Lithium stearate -- 1013717005 Magnesite; magnesium carbonate; see
Particulates not otherwise regulated1309484 Magnesium oxide fume, as Mg -- 10557040 Magnesium stearate -- 10121755 S Malathion; o,o-dimethyl S-1(1,2-
dicarboethyoxyethyl) phosphorodithioate-- 10
108316 Maleic anhydride; cis-butenedioic anhydride 0.1 0.4Manganese and compounds, as Mn -- 0.2
7439965 Manganese fume, as Mn -- 0.2 -- 312079651 S Manganese, cyclopentadienyl-tricarbonyl, a
Mn-- 0.1
Manganese tetroxide -- 0.2Marble; calcium carbonate; see Particulates not otherwise regulated
85
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
101779 S MDA; see 4,4'-Methylene dianiline101688 MDI; see Methylene bis(phenylisocyanate)7439976 S Mercury alkyls, as Hg -- 0.01 0.04 mg/M3 -- 0.037439976 S Mercury, metallic and inorganic compounds
as Hg-- 0.025 0.1 mg/M3
7439976 S Mercury aryl compounds as Hg -- 0.01 C108678 Mesitylene; see 1,3,5-Trimethylbenzene141797 Mesityl oxide; 4-methyl-3-pentene-2-one 15 60 25 10079414 S Methacrylic acid 20 7074828 Methane (h) --74931 Methanethiol; see Methyl mercaptan67561 Methanol; see Methyl alcohol16752775 S Methomyl -- 2.572435 Methoxychlor; 1,1,1-trichloro-2,2-bis(p-
methoxyphenyl)ethane-- 10
109864 S 2-Methoxyethanol 5 16110496 2-Methoxyethyl acetate 5 2476380 Methoxyflurane 2 13150765 4-Methoxyphenol -- 579209 Methyl acetate 200 610 250 76074997 Methyl acetylene; propyne 1,000 1,650
Methyl acetylene-propadiene mixture; MAPP 1,000 1,800 1250 225096333 S Methyl acrylate 10 35126987 S alpha-Methylacrylonitrile 1 3624419 2-Methylbutyl acetate; see Pentyl acetate109875 Methylal; dimethoxymethane 1,000 3,10067561 S Methyl alcohol; methanol 200 260 1000 ppm 250 32574895 Methylamine 5 6.4 15 19108112 Methyl amyl alcohol; see Methyl isobutyl
carbinol110430 Methyl n-amyl ketone; 2-heptanone 50 235100618 S N-Methylaniline; monomethylaniline 0.5 295534 o-Methylaniline; see o-Toluidine74839 S Methyl bromide 1 3.88 20 ppm591786 S Methyl butyl ketone; 2-hexanone 5 2074873 Methyl chloride 50 105 300 ppm 100 21071556 Methyl chloroform; 1,1,1-trichloroethane 350 1900 800 ppm 450 2450107302 Methyl chloromethyl ether; see Section 520975058 Methyl cyanide; see Acetonitrile137053 Methyl 2-cyanoacrylate 0.2 0.908 4108872 Methylcyclohexane 400 1,60025639423 Methylcyclohexanol (meta- and para-isomer
mixture)50 235
86
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
583608 S o-Methylcyclohexanone 50 230 75 34512108133 S 2-Methylcyclopentadienyl manganese
tricarbonyl, as Mn-- 0.2
8022002 S Methyl demeton; a mixture of o,o-dimethyl o-(2-(ethylthio)ethyl) phosphorothioate and o,o-dimethyl S-(2-(ethylthio)-ethyl) phosphorothioate
-- 0.5
101144 S 4,4'-Methylene bis(2-chloroaniline), see also Section 5215
-- 0.01
5124301 Methylene bis(4-cyclohexylisocyanate); hydrogenated MDI
0.005 0.054
101688 Methylene bis(phenylisocyanate); MDI; diphenylmethane diisocyanate
0.005 0.051
75092 Methylene chloride; dichloromethane (see also section 5202)
25 87 125 435
101779 S 4,4'-Methylene dianiline; MDA (see also Sections 1535 and 5200 )
0.01 0.08 0.1 0.8
78933 Methyl ethyl ketone; MEK; 2-butanone; ethyl methyl ketone
200 590 300 885
1338234 Methyl ethyl ketone peroxide 0.2 1.5 C107313 Methyl formate 100 250 150 37560344 S Methyl hydrazine; monomethyl hydrazine 0.01 0.01974884 S Methyl iodide 2 10110123 Methyl isoamyl ketone 50 234108112 S Methyl isobutyl carbinol; 4-methyl-2-pentanol;
methyl amyl alcohol25 100 40 165
108101 Methyl isobutyl ketone; Hexone 50 205 75 300624839 S Methyl isocyanate 0.02 0.05563804 Methyl isopropyl ketone 200 70574931 Methyl mercaptan 0.5 180626 Methyl methacrylate; methyl 2-methyl-2-
propenoate50 205 100 410
298000 S Methyl parathion; o,o-dimethyl o-(p-nitrophenyl) phosphorothioate
-- 0.2
107879 Methyl propyl ketone; 2-pentanone 200 700 250 875681845 Methyl silicate; tetramethyl silicate 1 698839 alpha-Methylstyrene; 1-methyl-1-
phenylethene50 240 100 485
77781 Methyl sulfate; see Dimethyl sulfate1634044 Methyl tert-butyl ether; MTBE 40 14421087649 Metribuzin -- 57786347 S Mevinphos; 2-carbomethoxyl-1-propen-2-yl
dimethyl phosphate0.01 0.1 0.03 0.3
Mica, see SilicatesMineral wool fiber; see Particulates not otherwise regulated
7439987 Molybdenum, insoluble compounds, as Mo Total dust
-- 10
7439987 Molybdenum, insoluble compounds, as Mo Respirable fraction (n)
-- 3
Molybdenum, soluble compounds, as Mo -- 0.5(n)
87
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
6923224 Monocrotophos -- 0.25100618 Monomethylaniline; see N-Methylaniline60344 Monomethylhydrazine; see Methyl hydrazine110918 S Morpholine; tetrahydro-4H-1, 4-oxazine 20 70 30 1057647010 Muriatic acid; see Hydrogen chloride8030317 Naphtha, coal tar 100 40091203 Naphthalene 10 50 15 75134327 alpha-Naphthylamine; 1-naphthylamine, see
Section 520991598 beta-Naphthylamine; 2-naphthylamine, see
Section 520963252 1-Naphthyl N-methylcarbamate; see Carbaryl25551284 Naphthalene diisocyanate; NDI 0.01 0.085 C7440019 Neon (h)13463393 Nickel carbonyl; Ni (CO)4 0.001 0.0077440020 Nickel metal, as Ni -- 1
Nickel, insoluble compounds, as Ni -- 1Nickel, soluble compounds, as Ni -- 0.1
54115 S Nicotine; 1-methyl-2-(3-pyridyl)-pyrrolidine 0.075 0.51929824 Nitrapyrin Total dust -- 101929824 Nitrapyrin Respirable fraction(n) -- 57697372 Nitric acid 2 5 4 1010102439 Nitric oxide; NO 25 30100016 S p-Nitroaniline -- 398953 S Nitrobenzene 1 5100005 S p-Nitrochlorobenzene; 1-chloro-4-
nitrobenzene0.1 0.64
92933 4-Nitrodiphenyl, see Section 520979243 Nitroethane 100 3107727379 Nitrogen (h) --10102440 Nitrogen dioxide 1 1.8
Nitrogen tetroxide; N2O4; see Nitrogen dioxide7783542 Nitrogen trifluoride 10 2955630 S Nitroglycerin (k) -- 0.175525 Nitromethane 2 5108032 1-Nitropropane 25 9079469 2-Nitropropane 10 3562759 N-Nitrosodimethylamine, see Section 52091321126, S Nitrotoluene 2 1199081, S Nitrotoluene 2 1188722, S Nitrotoluene 2 1199990 S Nitrotoluene 2 1176062 Nitrotrichloromethane; see Chloropicrin
88
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
10024972 Nitrous oxide 50 90111842 Nonane 200 1,050
Nuisance particulates, see Particulates not otherwise regulated Total dust
-- 10
Nuisance particulates, see Particulates not otherwise regulated Respirable fraction(n)
-- 5
2234131 S Octachloronaphthalene -- 0.1 -- 0.3111659 Octane 300 1,450 375 18008012951 Oil (mineral) mist, particulate -- (5)(l)
Oil (vegetable) mists (except castor, cashew nut or similar irritant oils); see Nuisance particulatesOrganic arsenic compounds; see Arsenic, organic
20816120 Osmium tetroxide, as Os 0.0002 0.002 0.0006 0.006144627 Oxalic acid -- 1 -- 27783417 Oxygen difluoride 0.05 0.1 C10028156 Ozone 0.1 0.2 0.3 0.68002742 Paraffin wax fume -- 21910425, 2074502
S Paraquat, total particulates -- 0.5
1910425, 2074502
S Paraquat, respirable sizes -- 0.1(n)
56382 S Parathion; o,o-diethyl o-(p-nitrophenyl) phosphorothioate
-- 0.1
Particulates not otherwise regulated Total dust
-- 10
Particulates not otherwise regulated Respirable fraction(n)
-- 5
Particulate polycyclic; aromatic hydrocarbons (PPAH) see Coal tar pitch volatilesPCB; see Chlorodiphenyl
87865 S PCP; see Pentachlorophenol19624227 Pentaborane 0.005 0.01 0.015 0.031321648 S Pentachloronaphthalene -- 0.587865 S Pentachlorophenol; PCP -- 0.5115775 Pentaerythritol; tetrakis-
(hydroxymethyl)methane; tetra-methylolmethane; see Particulates not otherwise regulated
109660 Pentane 600 1,800107879 2-Pentanone; see Methyl propyl ketone628637, 626380, 123922, 625161, 620111, 624419
Pentyl acetate 50 266 100 532
67721 Perchloroethane; see Hexachloroethane127184 Perchloroethylene 25 170 300 ppm 100 685594423 Perchloromethyl mercaptan;
trichloromethanethiol0.1 0.8
7616946 Perchloryl fluoride; C1O3F 3 14 6 28382218 Perfluoroisobutylene 0.01 0.082 C
89
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
Perlite Total dust -- 10Perlite Respirable fraction(n) -- 5
108952 S Phenol 5 1992842 S Phenothiazine; dibenzothiazine -- 5106503 S p-Phenylenediamine -- 0.1101848 Phenyl ether, vapor 1 7100425 Phenylethylene; see Styrene122601 S Phenyl glycidyl ether, PGE;1,2-epoxy-3-
phenoxypropane0.1 0.6
100630 S Phenylhydrazine 5 20 10 45108985 Phenyl mercaptan 0.5 2638211 Phenylphosphine 0.05 0.25 C298022 S Phorate; o,o-diethyl S-
(ethylthio)methylphosphorodithioate-- 0.05 -- 0.2
75445 Phosgene; carbonyl chloride; COCl2 0.1 0.47803512 Phosphine; PH3 0.3 0.4 1 17664382 Phosphoric acid -- 1 -- 37723140 Phosphorus, yellow -- 0.110025873 Phosphorus oxychloride 0.1 0.610026138 Phosphorus pentachloride 0.1 11314803 Phosphorus pentasulfide; P2S5 -- 1 -- 37719122 Phosphorus trichloride 0.2 1.5 0.5 385449 Phthalic anhydride 1 6626175 m-Phthalodinitrile -- 51918021 Picloram Total dust -- 101918021 Picloram Respirable fraction(n) -- 588891 S Picric acid; 2,4,6-trinitrophenol -- 0.183261 Pindone; 2-pivalyl-1, 3-indandione 0.1142643 Piperazine dihydrochloride -- 526499650 Plaster of Paris; calcium sulfate hemihydrate;
see Particulates not otherwise regulated7440064 Platinum, metal -- 1
Platinum, soluble salts, as Pt -- 0.002Polychlorobiphenyls, see ChlorodiphenylPolytetrafluoroethylene, decomposition products
-- (m)
Portland Cement; see Particulates not otherwise regulated
1310583 Potassium hydroxide; caustic potash -- 2 C593293 Potassium stearate -- 1074986 Propane 1000 1800 (h)
107197 S Propargyl alcohol; 2-propyn-1-o1 1 257578 beta-Propiolactone, see Section 5209 0.5 1.579094 Propionic acid 10 30
90
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
114261 Propoxur; 2-isopropoxyphenyl N-methylcarbamate
0.5
109604 n-Propyl acetate 200 840 250 105071238 S n-Propyl alcohol 200 500 250 625115071 Propylene (h) --78875 Propylene dichloride; 1,2-dichloropropane 75 350 110 5106423434 S Propylene glycol dinitrate; PGDN 0.05 0.3107982 S Propylene glycol monomethyl ether 100 360 150 540108656 S Propylene glycol monomethyl ether acetate 100 541 150 81175558 S Propyleneimine; 2-methylaziridine 2 575569 Propylene oxide; 1,2-epoxy-propane 2 4.75627134 n-Propyl nitrate 25 107 40 17074997 Propyne; see Methylacetylene8003347 Pyrethrum -- 5110861 Pyridine 5 15106514 Quinone 0.1 0.4121824 RDX; see Cyclonite108463 Resorcinol 10 45 20 907440166 Rhodium, metal -- 0.17440166 Rhodium, metal Insoluble compounds, as Rh -- 0.17440166 Rhodium, metal Soluble salts, as Rh -- 0.001299843 Ronnel; o,o-dimethyl o-(2,4,5-trichlorophenyl)
phosphorothioite-- 10
Rosin core solder, pyrolysis products, as formaldehyde
-- 0.1
83794 Rotenone, commercial -- 51309371 Rouge; see Particulates not otherwise
regulatedRubber solvent (Naphtha) 400 1,600Selenium compounds, as Se -- 0.2
7783791 Selenium hexafluoride 0.05 0.4136787 Sesone; sodium 2,4-dichloro-
phenoxyethylsulfate Total dust-- 10
Sesone; sodium 2,4-dichloro-phenoxyethylsulfate Respirable fraction(n)
-- 5
61790532 Silica, amorphous Diatomaceous earth Total dust
-- 6
61790532 Silica, amorphous Diatomaceous earth Respirable fraction(n)
-- 3
61790532 Silica, amorphous Diatomaceous earth Precipitated and gel
-- 6
14464461 Silica, crystalline Cristobalite, respirable dust -- 0.0514808607 Silica, crystalline Quartz, respirable dust -- 0.114808607 Silica, crystalline Quartz, total dust -- 0.360676860 Silica, crystalline Silica, fused, respirable dust -- 0.115468323 Silica, crystalline Tridymite, respirable dust -- 0.05
91
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
1317959 Silica, crystalline Tripoli, respirable dust -- 0.1Silicates (<1% crystalline silica)
12001262 Silicates (<1% crystalline silica) Mica (respirable dust)
-- 3
Silicates (<1% crystalline silica) Soapstone, total dust
-- 6
Silicates (<1% crystalline silica) Soapstone, respirable dust
-- 3
Silicates (<1% crystalline silica) Talc (containing asbestos); see Section 5208
14807966 Silicates (<1% crystalline silica) Talc (containing no asbestos fibers), respirable dust
-- 2
Tremolite (containing no asbestos fibers), respirable dust
-- 2
7440213 Silicon; see Particulates not otherwise regulated
409212 Silicon carbide; SiC; see Particulates not otherwise regulated
7803625 Silicon tetrahydride; silane 5 77440224 Silver metal, as Ag -- 0.01
Silver, soluble compounds, as Ag -- 0.01Soapstone, see Silicates
26628228 S Sodium azide 0.1 0.3 C7631905 Sodium bisulfite -- 5136787 Sodium 2,4-dichlorophenoxyethyl sulfate; see
Sesone62748 S Sodium fluoroacetate -- 0.05 -- 0.151310732 Sodium hydroxide; caustic soda -- 2 C7681574 Sodium metabisulfite -- 5822162 Sodium stearate -- 109005258 Starch; see Particulates not otherwise
regulated7789062 Strontium chromate, as Cr (see also
Sections 1532.2, 5206 & 8359)-- 0.0005
Stearates; see specific compound7803523 Stibine; SbH3 0.1 0.58052413 Stoddard solvent 100 52557249 Strychnine -- 0.15100425 S Styrene (monomer); phenylethylene 50 215 500 ppm 100 4259014011 Subtilisins (as pure crystalline proteolytic
enzymes)-- 0.00006(r)
57501 Sucrose; see Particulates not otherwise regulated
74222972 Sulfometuron methyl -- 3.53689245 S Sulfotep; tetraethyl dithionopyrophosphate 0.27446095 Sulfur dioxide 2 5 5 102551624 Sulfur hexafluoride 1,000 6,0007664939 Sulfuric acid -- 1 -- 3
92
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
10025679 Sulfur monochloride; S2Cl2 1 6 C5714227 Sulfur pentafluoride; S2F10 0.01 0.1 C7783600 Sulfur tetrafluoride 0.1 0.4 C2699798 Sulfuryl fluoride; SO2F2 5 20 10 4035400432 Sulprofos 193765 2,4,5-T;2,4,5-trichlorophenoxyacetic acid -- 10
Talc; see Silicates7440257 Tantalum metal dust, as Ta -- 51314610 Tantalum oxide dust, as Ta -- 578308 TCP; see Triorthocresyl phosphate584849 TDI; see Toluene-2,4-diisocyanate3689245 S TEDP; see Sulfotep
Tellurium and compounds, as Te -- 0.17783804 Tellurium hexafluoride 0.02 0.23383968 Temephos; o,o,o' ,o'-tetramethyl o,o'-thiodi-p-
phenylene phosphorothioate Total dust-- 10
Temephos; o,o,o' ,o'-tetramethyl o,o'-thiodi-p-phenylene phosphorothioate Respirable fraction(n)
-- 5
107493 S TEPP; tetraethyl pyrophosphate; 0.004 0.05100210 Terephthalic acid -- 10
Terphenyls 0.5 5 C79276 1,1,2,2-Tetrabromoethane; see Acetylene
tetrabromide76119 1,1,1,2-Tetrachloro-2,2-difluoroethane 500 417076120 1,1,2,2-Tetrachloro-1,2-difluoroethane;
fluorocarbon 112500 4,170
79345 S 1,1,2,2-Tetrachloroethane; acetylene tetrachloride
1 7
127184 Tetrachloroethylene; see Perchloroethylene56235 Tetrachloromethane; see Carbon tetrachloride1335882 S Tetrachloronaphthalene -- 23689245 Tetraethyl dithionopyrophosphate; see
Sulfotep78002 S Tetraethyl lead; tetraethylplumbane, as Pb -- 0.075107493 Tetraethyl pyrophosphate; see TEPP109999 Tetrahydrofuran 200 590 250 73575741 S Tetramethyl lead; tetramethylplumbane, as Pb -- 0.075115775 Tetramethylolmethane; see Pentaerythritol3333526 S Tetramethyl succinonitrile (decomposition
product of 2,2'-azobisisobutyronitrile)0.5 3
137268 Tetramethyl thiuram disulfide, see Thiram509148 Tetranitromethane 0.005 0.047722885 Tetrasodium pyrophosphate -- 5479458 S Tetryl; 2,4,6-trinitrophenylmethylnitramine -- 1.5
93
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
S Thallium, soluble compounds, as Tl -- 0.1109999 THF; see Tetrahydrofuran
4,4'-Thiobis(6-tert-butyl-m-cresol) Total dust -- 1096695 4,4'-Thiobis(6-tert-butyl-m-cresol) Respirable
fraction(n)-- 5
68111 S Thioglycolic acid 1 3.87719097 Thionyl chloride 1 5 C137268 Thiram; bis(dimethylthiocarbamoyl) disulfide -- 5
S Tin, organic compounds, as Sn -- 0.1 -- 0.221651194 Tin, tin oxide and inorganic compounds,
except SnH4, as Sn-- 2
13463677 Titanium dioxide, as Ti; see Particulates not otherwise regulated
137268 TMTD; see Thiram118967 TNT; see 2,4,6-Trinitrotoluene108883 S Toluene; toluol 50 188 500 ppm 150 560584849 Toluene-2,4-diisocyanate; TDI 0.005 0.04 0.02 ppm 0.02 0.15108441 S m-Toluidine 2 995534 S o-Toluidine; o-methylaniline 2 9106490 S p-Toluidine 2 98001352 Toxaphene; see Chlorinated camphene115866 TPP; see Triphenyl phosphate
Tremolite, nonasbestiform; see Silicates75252 Tribromomethane; see Bromoform126738 Tributyl phosphate 0.2 2.576039 Trichloroacetic acid 1 5120821 1,2,4-Trichlorobenzene 5 40 C50293 1,1,1,-Trichloro-2,2-bis(p-
chlorophenyl)ethane; see DDT71556 1,1,1-Trichloroethane; see Methyl chloroform79005 S 1,1,2-Trichloroethane 10 4579016 Trichloroethylene; trichloroethene 25 135 300 ppm 100 53775694 Trichlorofluoromethane; Fluorocarbon 11 1,000 5,600 C67663 Trichloromethane; see Chloroform594423 Trichloromethanethiol; see Perchloromethyl
mercaptan1321659 S Trichloronaphthalene -- 576062 Trichloronitromethane; see Chloropicrin93765 2,4,5-Trichlorophenoxyacetic acid see 2,4,5-T96184 1,2,3-Trichloropropane 10 6076131 1,1,2-Trichloro-1,2,2- trifluoroethane 1000 7600 2000 ppm 1250 950078308 Tricresyl phosphate; see Triorthocresyl
phosphate13121705 Tricyclohexyltin hydroxide; see Cyhexatin102716 Triethanolamine -- 5121448 S Triethylamine 1 4.1 C
94
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
112492 S Triethylene glycol dimethyl ether, Triglyme 5 3675638 Trifluorobromomethane 1,000 6,1002451629 1,3,5-Triglycidyl-s-triazinetrione 0.005552307 Trimellitic anhydride 0.005 0.04 C75503 Trimethylamine 5 12 15 36
Trimethylbenzene, all isomers 25 125121459 Trimethyl phosphate 2 1088891 2,4,6-Trinitrophenol; see Picric acid479458 2,4,6-Trinitrophenylmethyl nitramine; see
Tetryl118967 S 2,4,6-Trinitrotoluene; TNT -- 0.578308 S Triorthocresyl phosphate -- 0.1603349 Triphenylamine -- 5115866 S Triphenyl phosphate; TPP -- 37440337 Tungsten metal, as W -- 5
Tungsten, insoluble compounds, as W -- 5 -- 10Tungsten, soluble compounds, as W -- 1 -- 3
8006642 Turpentine 100 560Uranium (natural), insoluble compounds, as U -- 0.2 -- 0.6Uranium (natural), soluble compounds, as U -- 0.05
110623 Valeraldehyde 50 1751314621 Vanadium pentoxide (V2O5), respirable dust
and fume-- 0.05(n)
75014 S VC; see Vinyl chloride, Section 5210Vegetable oil mists (except castor, cashew nut or similar irritant oils); see Particulates not otherwise regulated
108054 Vinyl acetate 10 30 15 45100425 Vinylbenzene; see Styrene593602 Vinyl bromide; bromoethylene 5 2075014 S Vinyl chloride, see Section 5210 1107131 S Vinyl cyanide, see Acrylonitrile, Section 5213100403 S 4-Vinyl cyclohexene 0.1 0.4106876 S Vinyl cyclohexene dioxide 0.1 0.5775354 Vinylidene chloride; 1,1-dichloroethylene 1 475387 Vinylidene fluoride 100 26225013154 Vinyltoluene 50 2408030306 VM & P (Varnish Makers and Painters)
Naphtha300 1,350 400 1800
81812 Warfarin; 3-(alpha-acetonyl-benzyl)-4-hydroxycoumarin
-- 0.1
Welding fumes; total particulates (see also individual constituents)
-- 5
Wood dust All soft and hard woods, except Western red cedar
-- 5 -- 10
Wood dust, Western red cedar-- -- 2.5
95
Chemical Abstracts Registry Number (a)
Skin(b) Name(c) PEL (d) ppm(e)
PEL (d) mg/M3(f)
Ceiling(g) STEL (o) ppm(e)
STEL (o) mg/M3(f)
1330207 Xylene; xylol; dimethylbenzene 100 435 300 ppm 150 6551477550 S m-Xylene-a,a'-diamine -- 0.1 C1300738 S Xylidine; aminodimethylbenzene 0.5 2.5
Yttrium compounds, as Y -- 17646857 Zinc chloride fume -- 1 -- 213530659 Zinc chromate, as Cr (see also Sections
1532.2, 5206 & 8359)-- 0.005
15930946 Zinc chromate hydroxide, as Cr (see also Sections 1532.2, 5206 & 8359)
-- 0.005
1314132 Zinc oxide fume -- 5 -- 10Zinc oxide dust, see Particulates not otherwise regulated
11103869 Zinc potassium chromate, as Cr (see also Sections 1532.2, 5206 & 8359)
-- 0.005
557051 Zinc stearate -- 1037300235 Zinc yellow, as Cr (see also Sections 1532.2,
5206 & 8359)-- 0.005
Zirconium compounds, as Zr -- 5 -- 10
Footnotes to Table AC-1
(a) The Chemical Abstracts Service Registry Number is a designation used to identify a specific compound or substance regardless of the naming system; these numbers were obtained from the Desk Top Analysis Tool for the Common Data Base and from the Chemical Abstracts Indexes.
(b) Refer to section 5155(d) for the significance of the Skin notation.
(c) Trade Names Removed from Table AC-1.
Trade Name Chemical/Generic Name Abate see Temephos Ammate see Ammonium Sulfamate Aqualin see Acrolein Arasan see Thiram Azodrin see Moncrotophos Baygon see Propoxur Bidrin see Dicrotophos Butyl Cellosolve see 2-Butoxyethanol Cellosolve see 2-Ethoxyethanol Cellosolve Acetate see 2-Ethoxyethyl acetate Compound 1080 see Sodium Fluoracetate Coyden see Clopidol Crag Herbicide see Sesone Cythion see Malathion Dasanit see Fensulfothion Delnav see Dioxathion Dibrom see Naled Difolatan see Captafol Disyston see Disulfoton
Dowtherm Asee Phenylether and Biphenyl
96
Dursban see Chloropyrifos Dyfonate see Fonofos Fermate see Ferbam Freons see Fluorocarbons Furadan see Carbofuran Guthion see Azinphos Methyl Korlan see Ronnel Lannate see Methomyl Mariate see Methoxychlor MLT see Malathion Moxie see Methoxychlor Nialate see Ethion Nankor see Ronnel Phosdrin see Mevinphos Pival see Pindone Plictran see Cyhexatin Santobrite see Pentachlorophenol Sevin see Carbaryl Systox see Demeton Teflon see Polytetrafluoroethylene Thimet see Phorate Thiodan see Endosulfan Tordon see Picloram Trolene see Ronnel Vapona see Dichlorvos Weedone 638 see 2, 4-D Zoalene see Dinitolmide
(d) For the definition and the application of the Permissible Exposure Limit (PEL), refer to section 5155(b) and (c)(1).
(e) Parts of gas or vapor per million parts of air by volume at 25oC and 760mm Hg pressure.
(f) Milligrams of substance per cubic meter of air at 25oC and 760mm Hg pressure.
(g) Refer to section 5155(b) and (c)(3) for the significance of the Ceiling notation. A "C" notation in this column means the values given in the PEL columns are ceiling values. A numerical entry in this column represents a ceiling value in addition to the TWA values.
(h) A number of gases and vapors, when present in high concentrations, act primarily as asphyxiants without other adverse effects. A concentration limit is not included for each material because the limiting factor is the available oxygen. (Several of these materials present fire or explosion hazards.)
(i) Coal tar pitch volatiles (benzene or cyclohexane-soluble fraction) include fused polycyclic hydrocarbons (some of which are known carcinogens) which volatilize from the distillation residues of coal, petroleum (excluding asphalt), wood, and other organic matter. Asphalt (CAS 8052-42-4, and CAS 64742-93-4) is not covered under the "coal tar pitch volatiles" standard.
(j) This standard applies to the cotton waste processing operations of waste recycling (sorting, blending, cleaning, and willowing) and garnetting. It does not apply to cotton gins, cottonseed oil industry, or operations covered by section 5190.
(k) A PEL of 0.05 ppm shall apply to exposures involying a mixture of ethylene glycol dinitrate and nitroglycerin.
(l) As sampled by method that does not collect vapor.
(m) Thermal decomposition of the fluorocarbon chain in air leads to the formation of oxidized products containing carbon, fluorine and oxygen. An index of exposure to these products is possible through their alkaline hydrolysis followed by a quantitative determination of fluoride content. No particular concentration limit is specified pending evaluation of the toxicity of the products but concentrations should be kept below the sensitivity of the analytical method.
(n) The concentration and percentage of the particulate used for this limit are determined from the fraction passing a size selector with the following characteristics:
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Aerodynamic Diameterin Micrometers
(unit density sphere)≤ 22.53.5510
Source: American Conference of Governmental Industrial Hygienists TLV Committee 1968 Proceedings.
(o) Refer to sections 5155(b) and (c)(2) for the definition and application of the Short Term Exposure Limit (STEL).
(p) (Reserved)
(q) Fibers per cubic centimeter of air at 25oC and 760mm Hg pressure. To be considered a fiber for this limit the glass particle must be longer than 5µm, have a length to diameter ratio of three or more, and have a diameter less than 3µm. The National Institute for Occupational Safety and Health (NIOSH), Method 7400, Issue 2, August 15, 1994, which is hereby incorporated by reference, shall be used for measuring airborne fiber concentrations.
(r) Compliance with the subtilisins PEL is assessed by sampling with a high volume sampler (600-800 liters per minute) for at least 60 minutes.
(s) The concentration and percentage of the particulate used for this limit are determined from the fraction passing a size selector with the following characteristics:
Aerodynamic Diameterin Micrometers
(unit density sphere)01251020304050100
(t) Glutaraldehyde can cause occupational asthma and skin sensitization responses such as contact dermatitis. Exposure related symptoms may include one or more of the following: shortness of breath, chest tightness, wheeze, cough, skin rash, hives, and irritation of the nose, throat, skin or eye. Hazard communication training required by sections 5191 or 5194 shall address these health hazards and symptoms along with the measures taken by the employer to evaluate and control exposures that can include medical evaluations, exposure monitoring, ventilation systems, work practices, and personal protective equipment. The communication system required by section 3203 shall inform employees where to report possible health symptoms and where to ask questions, report concerns, and receive information about the employer’s evaluation and control measures.
(u) The Ceiling Limit of 0.05 ppm will take effect July 6, 2008. Until that time the following be in effect: PEL 0.05 ppm (8-hour time-weighted average) Ceiling Limit 0.2 ppm.
NOTE: Authority cited: Section 142.3, Labor Code. Reference: Sections 142.3 and 144.6, Labor Code.
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APPENDIX I
Signs and Symptoms of Select Agents and Toxins Used in Laboratories(Extracted form Bioterrorism Response Card Published by New York State Department of Health May 2003)
Disease Incubation Period
Early Symptoms Treatment Prophylaxis
Inhalational Anthrax
1-7 days (possibly up to days)
Non-specific: fever, malaise, cough, dyspnea, headache, vomiting, abdominal and chest pain.
Ciprofloxacin; doxycycline Combination therapy of ciprofloxacin or doxycycline, plus one or two other antimicrobials should be considered with inhalation anthrax. PCN should be considered if strain is susceptible.
Ciprofloxacin or doxycycline, with or without vaccination. If susceptible, PCN or amoxicillin should be considered.
Cutaneous Anthrax
1-12 days Painless or pruritic papule
Ciprofloxacin; doxycycline Combination therapy of ciprofloxacin or doxycycline, plus one or two other antimicrobials should be considered with inhalation anthrax. PCN should be considered if strain is susceptible.
Ciprofloxacin or doxycycline, with or without vaccination. If susceptible, PCN or amoxicillin should be considered.
Botulism (Includes Clostridium Boulinum and Botulinum Toxin)
Foodborne: 12-72 hours range, 2 hours – 8 days Inhalational: 12-80 hours
Usually none. If foodborne, possibly nausea, vomiting, abdominal cramps or diarrhea.
Supportive care – ventilation may be necessary. Trivalent equine antitoxin (serotypes A, B, E – available from CDC) should be administered immediately following clinical diagnosis.
None
Brucellosis Very variable, 5-60 days
Fever (often intermittent), headache, chills, heavy sweats, arthralgias.
Doxycycline plus streptomycin or rifampin. Alternatives: ofloxacin plus rifampin; doxycycline plus gentamicin; TMP/SMX plus gentamicin.
Doxycycline plus streptomycin or rifampin
Equine Encephaltides (Eastern, Western, Venezuelan)
2-6 days, Venezuelan 5-15 days, others
Non-specific: Sudden onset o malaise, fever, rigors, severe headache, photophobia, myalgias of legs and back.
Supportive care – analgesics, anticonvulsants as needed.
None
Pneumonic Plague (Yersinia pestis infection)
1-6 days Non-specific: high fever, cough, chills, dyspnea, headache, hemoptysis, nausea, vomiting, diarrhea.
Streptomycin; gentamicin. Alternatives: doxycycline; tetracycline; ciprofloxacin; and chloramphenicol.
Tetracycline; doxycycline; ciprofloxacin
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Signs and Symptoms of Select Agents and Toxins Used in Laboratories(Extracted form Bioterrorism Response Card Published by New York State Department of Health May 2003)
Disease Incubation Period
Early Symptoms Treatment Prophylaxis
Q fever (Coxiella burnetii infection)
10-40 days Fever, headache, chills, heavy sweats, arthralgias.
Tetracycline; doxycycline Tetracycline; doxycycline (may delay but not prevent illness).
Ricin (toxin from castor bean oil)
18-24 hours Inhalation: fever, weakness, cough, hypothermia, hypotension, cardiac collapse.
Supportive care. Treatment for pulmonary edema. Gastric decontamination if toxin is ingested.
None
Smallpox 12 days; range: 7-17 days
Non-specific: fever, malaise, headache, prostration, rigors, vomiting, severe backache.
Supportive care. Cidofovir shown to be effective in vitro.
Vaccination given within 3-4 days of exposure can prevent or decrease the severity of disease.
Staphylococcal enterotoxin B
3-12 hours for inhalation. Minutes to hours for ingestion.
Inhalation: Fever, chills, headache, myalgias, cough, nausea. Short incubation and rapid onset suggestive of chemical agent.
Supportive care. None
Tularemia (Francisella tularensis infection)
3-5 days; range: 1-14 days
Non-specific: fever, fatigue, chills, cough, malaise, body aches, headache, chest discomfort, GI symptoms.
Streptomycin; gentamicin. Alternative: ciprofloxacin
Tetracycline; doxycycline; ciprofloxacin
Viral hemorrhagic fevers (Ebola, arenavirus, filoviruses)
2-21 days; varies among viruses
Fever, myalgias, petechiae, easy bleeding, red itchy eyes, hematemesis.
Supportive care. Ribavirin may be effective for Lassa fever, Congo-Crimean hemorrhagic fever, Rift Valley fever.
Ribavirin may be effective for Lassa fever, Congo-Crimean hemorrhagic fever, Rift Valley fever.
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APPENDIX J
Risk Assessment of Work with Toxin and Determination of Personal Protective Equipment
(Revised 04/21/2011)
Description of agents:
Botulinum toxin, described as Level II agents (non-airborne). Dr. Lin is listed as the “Principal Investigator.”
Risk Assessment of Toxin
The following table lists the probability of exposure occurrence, consequences of exposure, and recommended protective measures. The probability of exposure occurrence is rated as low, moderate or high based on the use and probability of the exposure occurring. The consequences of exposure are rated as low, moderate or high based on the following:
Low level means the exposure identified would have little or no probability for harm. Moderate level means the exposure identified may have some probability for harm. High level means the exposure identified is likely to cause harm.
Any use with any of the following ratings for the probability of exposure occurrence and consequences of exposure was considered significant and recommended protective measures are listed:
Moderate Probability of Exposure and Moderate Consequence of Exposure High Probability of Exposure and Moderate Consequence of Exposure Moderate Probability of Exposure and High Consequence of Exposure High Probability of Exposure and High Consequence of Exposure
The recommended protective measures are determined based on the risk assessment of how the toxin is used. It should be noted that probability and consequences may vary due to the type of use of the toxin.
Use Probability of Exposure Occurrence
Consequences of Exposure
Recommended Protective Measures
Agent Specific Risk Assessment: Botulinum Toxin□ Low risk includes agents that are
handled in a diagnostic, nonpropagative manner (e.g., single specimen, no culture).
□ Moderate risk includes agents that are handled in a diagnostic, propagative manner. This level includes only the amounts necessary for experiments at hand (e.g., specimen cultured for diagnostic purposes or produced only in amounts required for the research or
Moderate High Use Biosafety Level 2 practices including the use of a Biosafety Cabinet for manipulations of the liquid.
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experiments being conducted).□ High risk includes agents that are
handled in large or highly pure quantities such as liters or grams. It would also include those agents and toxins used in restricted experiments or experiments that may increase virulence, and also includes high-risk use (e.g., centrifugation).
Amount of Toxin Used Relative to Lethal Dose (LD): May Exceed LD
Low High
Physical state of the toxin (solution or dry form): Solution
Low High
Volume of the Material Manipulated: Microliters
Low Moderate
methodology
Aerosolization of Toxin Given Physical State and Volume Used
Low Moderate
Is Controlled generation of aerosols Used for Testing: No
Low High
Are Pressurized Containers Used: No Low HighIs the Toxin Injected (e.g. Into Animals): Yes High High Train
individuals on animal injection techniques with non-toxic materials and demonstrate proficiency prior to actual work.
Is Glass Used to Store or Handle the Toxin: Yes, Hungate Culture Tubes Only
Moderate High Include broken glassware clean up procedures in SOPs and Biosafety Plan. Consider replacement of glass Hungate Tubes with plastic.
Decontamination of Non-Disposable Laboratory Coats prior to sending out for laundry.
High Moderate Non-Disposable laboratory coats will be soaked in 500 ppm bleach for a minimum of
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20 minutes.
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APPENDIX K
California State Polytechnic University, Pomona
Certification of Annual Review of Chemical Safety Plan for Laboratories
Signature of Reviewer Date of Review
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