calbiochem new products nov 2011
DESCRIPTION
The Calbiochem® brand of high quality small molecules have been cited in thousands of peer reviewed publications. From libraries and pathway panels to individual small molecules, the Calbiochem® line of products offers the widest and most cited selection of inhibitors and activators worldwide.TRANSCRIPT
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INtrODuCtOry DIsCOuNt
Inhibitorselect™ signaling Pathway Panels
EMD Millipore is a division of Merck KGaA, Darmstadt, Germany
small Molecules, Inhibitors, and Biochemicals
What’s New from Calbiochem®
NOVEMBEr 2011
Small molecules offer a powerful approach to temporally and spatially modulate the activity of individual proteins that control biological processes. This includes identifying signaling molecules that define and maintain the extensive intracellular communication networks controlling critical cellular functions.
Researchers traditionally perform signal transduction analysis as a linear path, restricting to a specific pathway in an isolated cell, but more recently, have undertaken more of a “systems” approach, involving dynamic interaction networks. Such dynamic analysis integrates high throughput molecular profiling, database and literature mining, mechanistic modeling, and cell culture experiments.
Recognizing the opportunities and challenges in analyzing signal transduction, EMD Millipore, has developed an array of Signaling Pathway Inhibitor Panels that contain carefully selected, potent small molecule inhibitors in convenient, cost effective formats. These panels allow the researcher to modulate their pathway of interest and gain useful information by manipulating specific proteins or families.
Calbiochem®: Publish or Perish
Nucleus
Off-State On-State
Frizzled Frizzled Frizzled Frizzled
• Casein Kinase IIInhibitor III, TBCA
• LY 294002 • PP2
• U0126
• SB 202190
• Rapamycin
• PKG Ia Inhibitor,Cell-Permeable
• K-252a, Nocardiopsis sp.
• KN-93; K-252a, Nocardiopsis sp.
• JNKInhibitor
• H-89, Dihydrochloride
• (5Z)-7-Oxozeaenol,Culvaria sp.
• GSK-3 Inhibitor IX
• Casein Kinase I Inhibitor, D4476
• K-252a, Nocardiopsis sp.• H-89, Dihydrochloride
• β-Catenin/Tcf Inhibitor, FH535
NFAT
CaderinCer
Caderin
APCAXIN
DSH TAB DSH
Rac1
α-Cateninβ-Catenin
β-Catenin
β-Catenin
GSK-3β
CK1 CKII
GSK-3β
TAK1 PI3-K
Akt
Src
ERKS MAP3Ks
CaMKII
PLCMEKKS
p38
CalnPKC
PDE
PKG
MAPKK4/7Rho Kinase
JNK
mTORNLKPKA
Proteasome
ERK Pathway
CellPolarity
Cell Survival
NFATPathway
PKCPathway
MAPKCascade
Cell Survival/Protein Synthesis
Gene Expression Gene ExpressionCell Fate Proliferation,Differentiation,
Adhesion, and Survival
APCAXIN
β-Catenin
RhoA
β-Catenin
β-Catenin
β-Catenin Degradation
Ca2+
TCF/LEFCREB
ATF2
c-Myc
WNTWNT5A
WNT1/11 WNT5
G Proteins
EMD Millipore offers the Calbiochem® brand of high quality small molecules that have been cited in thousands of peer-reviewed publications. From libraries and pathway panels to individual small molecules, the Calbiochem® line of products offers the widest and most cited selection of inhibitors and activators worldwide.
New! Wnt signaling Pathway Panel and small Molecules The Wnt signaling pathway is evolutionarily conserved and involved in fate specification, developmental cell proliferation, cell migration, and polarity. Wnt genes encode a large family of secreted, cysteine-rich proteins that are important in the development and maintenance of adult tissues. See inside for details.
Featuring
NOV2011
Nucleus
Off-State On-State
Frizzled Frizzled Frizzled Frizzled
• Casein Kinase IIInhibitor III, TBCA
• LY 294002 • PP2
• U0126
• SB 202190
• Rapamycin
• PKG Ia Inhibitor,Cell-Permeable
• K-252a, Nocardiopsis sp.
• KN-93; K-252a, Nocardiopsis sp.
• JNKInhibitor
• H-89, Dihydrochloride
• (5Z)-7-Oxozeaenol,Culvaria sp.
• GSK-3 Inhibitor IX
• Casein Kinase I Inhibitor, D4476
• K-252a, Nocardiopsis sp.• H-89, Dihydrochloride
• β-Catenin/Tcf Inhibitor, FH535
NFAT
CaderinCer
Caderin
APCAXIN
DSH TAB DSH
Rac1
α-Cateninβ-Catenin
β-Catenin
β-Catenin
GSK-3β
CK1 CKII
GSK-3β
TAK1 PI3-K
Akt
Src
ERKS MAP3Ks
CaMKII
PLCMEKKS
p38
CalnPKC
PDE
PKG
MAPKK4/7Rho Kinase
JNK
mTORNLKPKA
Proteasome
ERK Pathway
CellPolarity
Cell Survival
NFATPathway
PKCPathway
MAPKCascade
Cell Survival/Protein Synthesis
Gene Expression Gene ExpressionCell Fate Proliferation,Differentiation,
Adhesion, and Survival
APCAXIN
β-Catenin
RhoA
β-Catenin
β-Catenin
β-Catenin Degradation
Ca2+
TCF/LEFCREB
ATF2
c-Myc
WNTWNT5A
WNT1/11 WNT5
G Proteins
Inhibitorselect™ Wnt signaling Pathway Inhibitor Panel (Catalogue No. 681666)
EMD Millipore’s Calbiochem® Wnt Pathway Panel contains 15 carefully selected, cell-permeable, potent small molecules to
help determine specific gene and protein functionality along Wnt signaling pathways.
FEAturED sIGnALInG PAtHWAy PAnEL
Phosphorylation
Ubiquitin
GTP
Calbiochem® InhibitorsFor more information visit www.emdbiosciences.com/inhibitorselect
nEW PrODuCts
Description Catalogue No.
Bax Channel Blocker II, iMAC3 196806
Caspase Modulator I, 1541 264157
DAPK Inhibitor 324788
Meriolin 2 445820
p53-Snail Binding Inhibitor, GN25 506170
PKCθ/δ Inhibitor 539649
RNAi Enhancer, Enoxacin Sodium Salt 557305
Description Catalogue No.
ACC2 Inhibitor, CD-017-0191 104551
Adipogenesis Inducers Panel 121000Autotaxin Inhibitor I, S32826 189510Autotaxin Inhibitor II, HA130 189511Dual Specificity Protein Phosphatase 1/6 Inhibitor, BCI 317496
Glucagon-Like Peptide 1 Receptor Agonist II 346007
GSK-3 Inhibitor IV, SB-216763 361566
GSK-3 Inhibitor XXII, Compound A 361563
GSK3β Inhibitor XIX, IM-12 361565HDL Receptor SR-BI Inhibitor, BLT-1 373210Hexokinase II Inhibitor II, 3-BP 376817
InhibitorSelect™ FGF Signaling Pathway Inhibitor Panel 341612
InhibitorSelect™ IGF Signaling Pathway Inhibitor Panel 407249
Phosphatase Inhibitor Cocktail Set III, Lyophilized 524631
PI 3-K inhibitor IX, PIK-90 528117
PI 3-K Inhibitor XI, HWT 528119
PI3Kδ Inhibitor, SW30 526559
PTP LYP Inhibitor 540217
SIRT2 Inhibitor II, AK-2 566331
Description Catalogue No.
CFTR Inhibitor IV, PPQ-102 219677
CFTR-F508del Corrector II, Corr-4a 219673
Description Catalogue No.
Aminopeptidase N/CD13 Inhibitor 164606
APT1 Inhibitor, palmostatin B 178501
Autotaxin Inhibitor I, S32826 189510
Bax Channel Blocker II, iMAC2 196806
Bcr-abl Inhibitor III, GNF-5 197224
BCRP Inhbitor 197226
c-Met Kinase Inhibitor III 448105
c-Myc Inhibitor II 475957
C-Raf Inhibitor 475958
Caspase-3 Activator, BETT 235428
CDK Inhibitor II, LGR1406 219501
Ceramide Kinase Inhibitor II, NVP-231 219493
DAPK Inhibitor 324788
DNA Methyltransferase Inhibitor II, SGI-1027 260921
Dual Specificity Protein Phosphatase 1/6 Inhibitor, BCI 317496
Dvl-PDZ Domain Inhibitor II 322338
ESFTs Inhibitor, YK-4-279 330000
Fibroblast Growth Factor-2 Inhibitor, NSC37204 341598
Formin FH2 Domain Inhibitor, SMIFH2 344092
GAG Agonist, Adhesamine 362331
Glucagon-Like Peptide 1 Receptor Agonist II 346007
HDAC Inhibitor XXIV, OSU-HDAC-44 382181
Hesperadin 375680
Hexokinase II Inhibitor II, 3-BP 376817
Hh Signaling Pathway Modulators 373386
HIF Prolyl Hydroxylase Inhibitor 400084
HIF-Hydroxylase Inhibitor, DMOG 400091
Histone Acetyltransferase p300 Inhibitor, C646 382113
HMTase Inhibitor II, Chaetocin 382191
IM-412 401251
InhibitorSelect™ TGF-βR and BMPR Signaling Pathway Inhibitor Panel
616466
InhibitorSelect™ VEGF Signaling Pathway Inhibitor Panel 676502
JAK3 Inhibitor VII, AD412 420145
JMJD2 Inhibitor, 5-carboxy-8HQ 420201
MDMX Antagonist, SJ-172550 444155
Meriolin 3 445821
Mitaplatin 475851
MRP1 Inhibitor II, Reversan 475730
Neurotrophin Antagonist, Y1036 480870
NF-κB Activation Inhibitor VII, CID-2858522 480457
Nicotinamide Phosphoribosyltransferase Inhibitor, FK866 481908
Notch Transcription Factor Inhibitor SAHM1 491002
p53 Activator VII, STIMA-1 506168
PAD3 Inhibitor, Cl4-amidine 506281
PARP Inhibitor XV, UPF-1035 528825
Phosphatase Inhibitor Cocktail Set III, Lyophilized 524631
PI 3-K Inhibitor IX, PIK-90 528117
PI 3-K Inhibitor XI, HWT 528119
Description Catalogue No.
TNAP Inhibitor 613810
Apoptosis
Diabetes, Obesity, and Cardiovascular Disease
Cystic Fibrosis
Cancer
Bone Disorders
NOV2011
nEW PrODuCts
Description Catalogue No.
HDAC Inhibitor XXIV, OSU-HDAC-44 382181
Histone Acetyltransferase Inhibitor IV, CPTH2 382111
Histone Acetyltransferase p300 Inhibitor, C646 382113
HMTase Inhibitor II, Chaetocin 382191
LSD1 Inhibitor 489476
LSD1 Inhibitor II, S2101 489477
PAD3 Inhibitor, Cl4-amidine 506281
Protein Lysine Methyltransferase Inhibitor, UNC0321 476496
SIRT2 Inhibitor II, AK-1 566331
Description Catalogue No.
Dkk-1 Inhibitor, WAY-262611 317700
Dvl-PDZ Domain Inhibitor II 322338
GAG Agonist, Adhesamine 362331
Hesperadin 375680
Hh Signaling Pathway Modulators 373386
InhibitorSelect™ TGF-βR and BMPR Signaling Pathway Inhibitor Panel
616466
LSD1 Inhibitor 489476
LSD1 Inhibitor II, S2101 489477
Notch Transcription Factor Inhibitor SAHM2 491002
Pluripotin 540020
Protein Lysine Methyltransferase Inhibitor, UNC0321 476496
Pyrintegrin 544049
Rho Kinase Inhibitor VII 555556
Rho Kinase Inhibitor XI, Y-39983 555561
Tankyrase1/2 Inhibitor, XAV939 575545
V-ATPase Inhibitor, KM91104 672999
Wnt Antagonist III, Box6 681673
Wnt Antagonist III, CCT036477 681674
Description Catalogue No.
Cathepsin L Inhibitor, CAA0225 219502
γ-Secretase Inhibitor XXIII, Aβ42-Selective 565792
GSK-3 Inhibitor IV, SB-216763 361566
GSK-3 Inhibitor XXII, Compound A 361563
GSK3β Inhibitor XIX, IM-12 361565
LRRK2-IN-1 438193
Tau Aggregation Inhibitor, ATPZ, Cpd16 580222
Epigenetics
stem Cell Biology
neurodegeneration
Cancer (continued)Description Catalogue No.
PI 3-K/PDK-1 Inhibitor, NVP-BAG956 528121
PI3Kδ Inhibitor, SW30 526559
Polo-like Kinase Inhibitor IV, SBE13 528281
PP1 Analog III, 3-MB-PP1 529582
Proteasome Inhibitor X, PI-083 539187
PTP LYP Inhibitor 540217
Pyrintegrin 544049
Rac1 Inhibitor II 553511
RNAi Enhancer, Enoxacin Sodium Salt 557305
ROS Inhibitor, YCG063 557354
RXRα Inhibitor, K-80003 557451
Tankyrase1/2 Inhibitor, XAV939 575545
Topoisomerase IIα Inhibitor, TSC24 614852
Ursolic Acid 672315
USP7 Inhibitor, HBX 41,108 662084
Wnt Antagonist III, Box5 681673
Wnt Antagonist III, CCT036477 681674
NOV2011
Wnt Antagonist III, Box5 (Catalogue No. 681673)
A Wnt-5A-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5A-
mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and
MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that
mimics, instead of antagonizes, Wnt-5A biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide
sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via
direct FZD5 binding as is the case with Foxy5.
Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist
Dvl-PDZ Domain Inhibitor II (Catalogue No. 322338)
A cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ
domain (Kd = 10.6 µM) of Dvl, blocking Wnt3A-induced (10 ng/mL) transcription activity (~50% inhibition at 3 µM in
293 cell SuperTOPflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3
cells (by 16% in 72 h at ≥50 µM; IC50 = 12.5 µM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus
embryo deformation (effective conc. = 25 µM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular
endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nL/eye) in vivo.
2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625, Wnt Pathway Inhibitor V
ADDItIOnAL FEAturED PrODuCts FOr tHE InVEstIGAtIOn OF Wnt sIGnALInG
For more information visit www.emdbiosciences.com/inhibitors
O
O
HN N
HCO2H
H3C
t-boc-
CH3
CH3
CH3
CH3
CH3
0
O O
O
O
OO
O
O
OH
OHOH
SH
S
HN H
N
NH N
H
NH N
H
EMD MIllipore, the M logo, and InhibitorSelect are trademarks, and Calbiochem is a registered trademark of Merck KGaA, Darmstadt, Germany.Lit No. PR4100EN00 LS-SBU-11-04938 Printed in the USA. 10/2011. © 2011 Millipore Corporation. All rights reserved.
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