cajal atsb keynote speakers - fens.org files/cajal/2019... · later he got recruited to vib leuven...

CAJAL Neuroscience Training Course Advanced Techiques for synapse Biology Bordeaux, 13th October - 1st November, 2019

TheCAJALAdvancedNeuroscienceTrainingProgramme www.cajal-training.org

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Speakers

Tuesday15thOctober9:00InnaSlutsky,PhD(TelAvivUniversity,Israel)Dr.InnaSlutskyisanAssociateProfessorattheDepartmentofPhysiologyand Pharmacology and the Sagol School of Neuroscience at Tel AvivUniversity.Her research is focused on understanding the basicmechanisms thatmaintain synaptic plasticity andmemory function andinitiatememorydysfunctioninAlzheimer’sdisease(AD).Usingadvancedoptical imaging,electrophysiologyandmolecularbiology,Slutsky’s teamfocuseson identifying themechanismsthatdrivesynapticandcognitiveimpairments in AD. Dr. Slutsky and her team discovered how neuronal

activityandsensoryexperienceregulatemolecularcompositionofamyloid-beta(Dolevetal.,NatureNeurosci,2013),thephysiologicalroleofamyloid-beta(Abramovetal.,NatureNeurosci,2009),theroleofmagnesiumionincognitiveenhancement(Slutskyetal.,Neuron,2010)andthemechanismtriggeringsynaptichyperactivityattheearliestADstages(Gazitetal.,Neuron,2016;Fogeletal.,CellReports, 2014). Currently, her team is focused on stabilitymechanisms underlying neural circuit’sfunctioning(Slomowitzetal.,eLife,2015;Vertkinetal.,PNAS,2015)andfiringhomeostasisfailuresasthedriversofAD(Styr&Slutsky,NatureNeurosci2018;Frere&Slutsky,Neuron2018).Dr.SlutskycompletedherPhDintheHebrewUniversityofJerusalemandpost-doctoratestudiesatMIT.Slutsky is the recipientof theMetLife foundationprize inAlzheimer’s research,BernardKatzPrize inNeuroscience, Sieratzki Prize inNeuroscience, theNew Investigator Award in Alzheimer’sdiseasefromAmericanFederationforAgeingResearch,theSieratzkiPrizeandtheERCstartingandconsolidatorawards.SelectedPublications:

- Styr, B. & Slutsky, I. (2018). Imbalance between firing homeostasis and synaptic plasticitydrivesearly-phaseAlzheimer’sdisease.NatureNeuroscience21(4),463-473.

- Frere, S. & Slutsky, I. (2018). Alzheimer’s Disease: From Firing Instability to HomeostasisNetworkCollapse.Neuron97(1),32-58.

- GazitN,VertkinI,ShapiraI,HelmM,SlomowitzE,SheibaM,MorY,RizzoliS,andSlutskyI(2016). IGF-1 receptor differentially regulates spontaneous and evoked transmission viamitochondriaathippocampalsynapses.Neuron89(3),583-597.

- Frere, S &Slutsky, I (2016).Targeting PTEN interactions for Alzheimer’s disease.NatureNeurosci.19:416-418.

Tuesday17thOctober9:00MonicaDiLuca,PhD(UniversityofMilano,Italy)MonicaDiLucaisProfessorofPharmacologyandChairofNeuroscienceCenter(NeuroNest)theattheUniversityofMilano,whereshegraduatedinPharmacology. In1992shediscussedherPhDthesisat theUniversityofMilano, and in 1993 she completed a PhD programme inMolecularBiology at the University of Utrecht. Her primary research interest isrelatedtosynapticplasticityinphysiologicalandpathologicalconditions,with the primary aim to apply basic findings to the cure ofneurodegenerativediseasesasAlzheimerandParkinsonDisease.

Sheisauthorofmorethan200scientificpublicationsonpeerreviewedjournals;shewasandstilliscoordinatorofseveralEuropeanCommissionprojectsfromVIframeworkProgrammeon,whereshe



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alwayshadaclearvisionoftransdisciplinarityinvolvingallactorsincludingpatientsorganizationsatthe highest possible level of participation. She has been awarded of several honors including aLaureaHonorisCausaat theFacultyofMedicineandPharmacyof theUniversityofMons in2017andEMBOmembershipin2017andsince2008invitedmemberofEuropeanDanaAlliancefortheBrain.ShehasbeenPresidentofFederationofEuropeanNeuroscienceSocieties(FENS)from2014to2016.SheisactuallyPresidentofEuropeanBrainCouncil.SelectedPublications:

- PrefaceDrugdiscoveryinneurodegenerativedisorders:adefeatforpharmacology?CaraciF,KraneveldA,KrzanM,LucaMD.EurJPharmacol.2017Dec15;817:1.

- ADAM10 as a therapeutic target for brain diseases: from developmental disorders toAlzheimer'sdisease.MarcelloE,BorroniB,PelucchiS,GardoniF,DiLucaM.ExpertOpinTherTargets.2017Nov;21(11):1017-1026.

- Rabphilin3AretainsNMDAreceptorsatsynapticsitesthroughinteractionwithGluN2A/PSD-95complex.StanicJ,CartaM,EberiniI,PelucchiS,MarcelloE,GenazzaniAA,RaccaC,MulleC,DiLucaM,GardoniF.NatCommun.2015Dec18;6:10181

- Targeting glutamatergic synapses in Parkinson's disease. Gardoni F, Di LucaM. Curr OpinPharmacol.2015Feb;20:24-8.

Wednesday18thOctober9:00DanielChoquet,PhD(UniversityofBordeaux,France)Daniel Choquet obtained an engineering degree from Ecole Centrale(Paris, France) in 1984. He then got attracted to neuroscience andcompleted his PhD in the lab of Henri Korn at the Pasteur Institute(Paris), studying ion channels in lymphocytes.He got appointed tenureResearch officer at the CNRS in 1988. He then performed a post-

doctoral/sabbaticalattheDukeUniversity(NorthCarolina,USA)inthelaboratoryofMichaelSheetzwhere he studied the regulation of integrin-cytoskeletal linkage by force, and demonstrated thatcellscansenseandrespondtoextracellulartraction.HethensetuphisgroupinBordeaux(France)atthe Institute forNeurosciencewhere he got a directorship position at the CNRS. He launched aninterdisciplinary program on the combination of physiology, cell and chemical biology and highresolution imaging to study the functional role of the dynamic organization and trafficking ofneurotransmitter receptors in synaptic transmission. He is now heading the Institute forInterdisciplinaryNeuroscienceandtheBordeauxImagingCentercorefacility.HeisalsothedirectorofthecenterofexcellenceBRAIN,BordeauxRegionAquitaineInitiativeforNeuroscience.Hehasbeentherecipientof severalawards including the1990BronzeMedal fromtheCNRS, theResearchprizefromtheFondationpourlaRechercheMédicale(FRM),1997,theGrandPrixfromtheFrenchAcademyofSciences,PrixduCEAandthe2009SilverMedalfromtheCNRS.HeisaMemberof the Institut de France, the French Science Academy since November 2010 and Officier de laLégiond’honneur.HehasbeenawardedthreeERCadvancedgrantsin2008,2013and2018.Histeamdevelopsseveralresearchtopics,combiningneuroscience,physicsandchemistryinordertounravelthedynamicsandnanoscaleorganizationofmultimolecularreceptorcomplexesandtheirfunctional role in glutamatergic synaptic transmission.Recently, the teamhas engaged in amajorprogramtoanalyseandunderstandtheinterplaybetweenAMPAtypeglutamatereceptornanoscaledynamics,synapticplasticityandmemoryformationinthehealthyanddiseasedbrain.SelectedPublications:

- Linking Nanoscale Dynamics of AMPA Receptor Organization to Plasticity of ExcitatorySynapsesandLearning.ChoquetD.JNeurosci.2018Oct31;38(44):9318-9329.



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- ModulationofAMPAreceptorsurfacediffusionrestoreshippocampalplasticityandmemoryinHuntington'sdiseasemodels.ZhangH,ZhangC,VincentJ,ZalaD,BenstaaliC,SainlosM,Grillo-BoschD,DaburonS,CoussenF,ChoY,DavidDJ,SaudouF,HumeauY,ChoquetD.NatCommun.2018Oct15;9(1):4272

- CaMKIIMetaplasticityDrivesAβOligomer-MediatedSynaptotoxicity.OpazoP,VianadaSilvaS,CartaM,BreillatC,CoultrapSJ,Grillo-BoschD,SainlosM,CoussenF,BayerKU,MulleC,ChoquetD.CellRep.2018Jun12;23(11):3137-3145

- LengtheningoftheStargazinCytoplasmicTailIncreasesSynapticTransmissionbyPromotingInteractiontoDeeperDomainsofPSD-95.HafnerAS,PennAC,Grillo-BoschD,RetailleauN,Poujol C, Philippat A, Coussen F, Sainlos M, Opazo P, Choquet D. Neuron. 2015 Apr22;86(2):475-89.

Tuesday22ndOctober9:00Dietmar Schmucker, PhD (Leuven Center for Brain & Disease Research,Belgium)ProfSchmuckerstudiedatLudwigMaximiliansUniversity inMunich (LMU)anddidhisPh.D.at theMax-Planck Institute inGoettingen,Germany.Thesubject was Drosophila Neurogenetics, his supervisor Dr. H. Jaeckle. Hewent on to do a 4 year postdoc in LosAngeleswith Larry Zipursky,HHMIInvestigatoratUCLA.Attheendof2001ProfSchmuckerstartedhisownlabas Assistant Professor at Harvard Medical School, Department ofNeurobiology, with promotion to Associated Professor in January 2008.

LaterhegotrecruitedtoVIBLeuvenattheendof2009andhasbeenagroupleaderatVIBsince.For2019hewasawardedaAlexandervonHumboldtProfessorshipwiththeopportunitytoexpandandcontinuehisresearchattheLIMESandDZNEinBonnGermany.Throughout his professional career his research interestwas on neuronalwiring,with a focus ongenetics, biochemistry and imaging. Prof Schmucker discovered the molecular diversity of theneuronal receptor Dscam1, an alternatively spliced gene providing tens of thousands of receptorisoforms, essential forneuronal self-avoidanceandaxonalbranching.His current studies focusonelucidatingmechanismsofaxonalbranching,axondegeneration/regeneration,CNSsynaptogenesis,and membrane receptor function/signaling. His group uses the model organisms Drosophila andXenopustropicalis.SelectedPublications:

- Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibitingsynapse formationSachse S, Lievens S, Ribeiro L, Dascenco D, Masschaele D, Horré K,Misbaer A, Vanderroost N, De Smet A, Salta E, ErfurthM, Kise Y, Nebel S, Van DelmW,Plaisance S, Tavernier J, De Strooper B, deWit J, Schmucker DEMBO JOURNAL, , e99669,2019

- SlitandReceptorTyrosinePhosphatase69DConferSpatialSpecificitytoAxonBranchingviaDscam1DascencoD*ErfurthM*IzadifarASongMSachseSBortnickRUrwylerOPetrovicMAyazDHeHKiseYThomasFKiddTSchmuckerDCELL,162,1140-54,2015*Theseauthorscontributedequally

- InvestigatingCNSsynaptogenesisatsingle-synapseresolutionbycombiningreversegeneticswithcorrelativelightandelectronmicroscopyUrwylerO,IzadifarA,DascencoD,PetrovicM,HeH,AyazD,KremerA,LippensS,BaatsenP,GuerinC,SchmuckerDDEVELOPMENT,142,394-405,2015

- Axonal wiring in neural development: Target-independent mechanisms help to establishprecisionandcomplexityPetrovicM,SchmuckerDBIOESSAYS,37,996-1004,2015



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Wednesday23rdoctobre9:00BrainPrizeWinners

Bart De Strooper, PhD (UK-Dementia Research Institute, UnitedKingdom)Bart De Strooper is scien'fic director of the UK-Demen%a ResearchIns$tutesinceOctober2016.HeisprofessorofmolecularmedicineattheKU Leuven andVIB, Belgiumandprofessor in demen8a research at theUniversityCollegeLondon,UK.

BartDe Strooper’s scien0ficwork focuses on the understanding of the fundamentalmechanismsthatunderlieAlzheimer’sandParkinson’sdisease.Hismajorfindingsare the roleofADAM10andpresenilin/gamma-secretase intheproteolysisoftheamyloidprecursorproteinandNotch,andhehasworkedonmicroRNA,mitochondria, andmore recently on the roleof thedifferentbrain celltypesinthepathogenesisofAlzheimer’sDisease.He received his M.D. in 1985 and Ph.D. in 1991 from KU Leuven. He worked as postdoctoralresearcher in the EuropeanMolecular Biology Laboratory (EMBL) in Heidelberg, Germany, in thelaboratoryofCarlosDo-.In 2018, Bart De Strooper, together with John Hardy, Chris<an Haas and Michel Goedert, wasawarded the Brain Prize for their groundbreaking research on the gene6c andmolecular basis ofAlzheimer disease. Other awards include the Potamkin Award of the American Academy ofNeurology in 2002 (USA). the 2003 Alois Alzheimer Award of the Deutscher Gesellscha* fürGerontopsychiatrieundpsychotherapie(Germany),theJosephMaisinPrizein2005forfundamentalbiomedical sciences, (FWO Flanders, Belgium), the 2008 Metlife Founda>on Award for medicalresearch(USA)andthe2018EuropeanGrandPrixforResearch(France).SelectedPublica-ons:

- TheroleofastrogliainAlzheimer'sdisease:pathophysiologyandclinicalimplications.ArranzAM,DeStrooperB.LancetNeurol.2019Apr;18(4):406-414.

- Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibitingsynapse formation. Sachse SM, Lievens S, Ribeiro LF,DascencoD,MasschaeleD,Horré K,MisbaerA,VanderroostN,DeSmetAS, SaltaE,ErfurthML,KiseY,NebelS,VanDelmW,PlaisanceS,TavernierJ,DeStrooperB,DeWitJ,SchmuckerD.EMBOJ.2019Mar15;38(6).pii:e99669

- Secretedamyloid-βprecursorproteinfunctionsasaGABABR1aligandtomodulatesynaptictransmission.RiceHC,deMalmazetD,SchreursA,FrereS,VanMolleI,VolkovAN,CreemersE,VertkinI,NysJ,RanaivosonFM,ComolettiD,SavasJN,RemautH,BalschunD,WierdaKD,SlutskyI,FarrowK,DeStrooperB,deWitJ.Science.2019Jan11;363(6423).pii:eaao4827

- Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. McInnes J, Wierda K,SnellinxA,BountiL,WangYC,Stancu IC,ApóstoloN,GevaertK,Dewachter I,Spires-JonesTL,DeStrooperB,DeWitJ,ZhouL,VerstrekenP.Neuron.2018Feb21;97(4):823-835.e8.

ChristianHaass,PhD(Ludwig-MaximiliansUniversity,Germany)Dr.HaassgraduatedinMolecularBiologyattheUniversityofHeidelberg,Germany. HewasapostdocandassistantprofessorofNeurologyattheHarvardMedicalSchool inthe instituteofDr.DennisSelkoe. Since1999he is theheadof thedivisionofBiochemistryat theLudwig-MaximiliansUniversityandsince2009heisalsothespeakeroftheGermanCenterforNeurodegenerative Diseases (DZNE) in Munich. Dr. Haass received anumber of prestigious awards, among them, the Gottfried Wilhelm



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Leibniz-Award of the Deutsche Forschungsgemeinschaft, the Potamkin Award of the AmericanAcademyofNeurology,anERCadvancedgrant,andmostrecentlythebrainprize.Dr.HaassisthespeakeroftheMunichClusterofSystemsNeurology(SyNergy).SelectedPublications:

- SecretedAPPModulatesSynapticActivity:ANovelTargetforTherapeuticIntervention?HaassC,WillemM.Neuron.2019Feb20;101(4):557-559.

- CSF progranulin increases in the course of Alzheimer's disease and is associated withsTREM2, neurodegeneration and cognitive decline. Suárez-Calvet M, Capell A, AraqueCaballeroMÁ,Morenas-RodríguezE,FellererK,FranzmeierN,KleinbergerG,ErenE,DemingY, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM,Morris JC, Levin J,DanekA,JuckerM,MastersCL,RossorMN,RingmanJM,ShawLM,TrojanowskiJQ,WeinerM, Ewers M, Haass C; Dominantly Inherited Alzheimer Network; Alzheimer's DiseaseNeuroimagingInitiative.EMBOMolMed.2018Dec;10(12).pii:e9712

- The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA andproteininmicebutnotinhumans.XiangX,PiersTM,WefersB,ZhuK,MallachA,BrunnerB,Kleinberger G, Song W, Colonna M, Herms J, Wurst W, Pocock JM, Haass C. MolNeurodegener.2018Sep6;13(1):49.

- An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affectsshedding and phagocytic function. Schlepckow K, Kleinberger G, Fukumori A, Feederle R,LichtenthalerSF,SteinerH,HaassC.EMBOMolMed.2017Oct;9(10):1356-1365.

Saturday26thOctober9:00Reinhard Jahn, PhD (Max Planck Institute for Biophysical Chemistry,Germany)ReinhardJahnstudiedbiologyandchemistryattheUniversitiesofFreiburgandGöttingen(doctorate in1981).Hewaspostdoctoral fellowatYaleandRockefeller University (1983-1985), and assistant professor at RockefellerUniversity (1985-1986). Between 1986 and 1991 he was junior researchgroup leaderat theMaxPlanck InstituteofPsychiatry inMunich.1991hemoved toYaleUniversityasassociate/fullprofessor forpharmacologyandcellbiologyandas investigatoroftheHowardHughesMedical Institute. In

1997 he becameDirector at theMax Planck Institute for Biophysical Chemistry. He has obtainedseveralawards including theLeibniz-Prize (2000), theErnst JungPrize forMedicine (2006), theSirBernhardKatzAward(2008),theHeinrichWielandPrize(2014)andtheBalzanPrize(2016).ElectedMemberships include theEuropeanMolecularBiologyOrganization (EMBO), theGermanNationalAcademyLeopoldina,theAcademiaEuropaea,andtheNationalAcademyofSciencesoftheUnitedStates of America. His research focuses on the molecular mechanism of exocytosis in neurons,focusingonthefunctionofSNAREproteinsandtheirregulationbyaccessoryproteins. Inaddition,hisgroupworksonthestructureandfunctionofsynapticvesicles,withparticularemphasisontheuptakeandstorageofaminoacidneurotransmitters.SelectedPublications:

- Hubrich, R.;Park, Y.; Mey, I.;Jahn, R.; Steinem, C.:SNARE-mediated fusion of singlechromaffingranuleswithpore-spanningmembranes.Biophysical Journal116(2),pp.308 -318(2019)

- Hubrich, B.; Kumar, P.; Neitz, H.;Grunwald, M.;Grothe, T.;Walla, P. J.;Jahn, R.;Diederichsen, U.:PNA hybrid sequences as recognition units in SNARE-protein-mimickingpeptides.AngewandteChemieInternationalEdition57(45),pp.14932-14936(2018)



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- Oroz,J.;Chang,B.J.;Wysoczanski,P.;Lee,C.T.;Perez-Lara,A.;Chakraborty,P.;Hofele,R.V.;Baker, J.D.; Blair, L. J.; Biernat, J.et al.:Structure andpro-toxicmechanismof thehumanHsp90/PPIase/Taucomplex.NatureCommunications9(1),4532(2018)

- Witkowska,A.;Jahn,R.:RapidSNARE-mediatedfusionofliposomesandchromaffingranuleswithgiantunilamellarvesicles.BiophysicalJournal113(6),pp.1251-1259(2017)

Monday28thOctober9:00ClaudiaBagni,PhD(UniversityofLausanne,Switzerland)My laboratory has a long-lasting interest in the study ofintellectual disabilities such as Fragile X Syndrome (FXS),Autism(ASD)andSchizophrenia(SCZ)inwhichtherecurringaspect is the dysregulation of the synaptic proteome. Theknowledgeweacquireexaminingmolecularmechanismsatthe synapses will offer a major inroad into theunderstanding of processes that govern, not only learning

and memory and human behavior, but disorders called “synaptopathies” that arise frommalfunctioningsynapses.Weuserodents,patients’cellsandrecentlyDrosophila.FXS,ASDandSCZarestillwithoutaneffectivecureandweaim,ultimatelywiththeuseofbiologicalmodels,humanstem cells and in collaboration with clinical researchers, to develop possible pharmacologicalapproachestomodulatesomeaspectsofthesesynaptopathies.SelectedPublication:

- ASynapticPerspectiveofFragileXSyndromeandAutismSpectrumDisorders.BagniC,ZukinRS.Neuron.2019Mar20;101(6):1070-1088

- Maintenance mechanisms of circuit-integrated axons. Mariano V, Domínguez-Iturza N,NeukommLJ,BagniC.CurrOpinNeurobiol.2018Dec;53:162-173.

- Thenon-codingRNABC1regulatesexperience-dependentstructuralplasticityandlearning.BrizV,RestivoL,PasciutoE,JuczewskiK,MercaldoV,LoAC,BaatsenP,GounkoNV,BorrecaA, Girardi T, Luca R, Nys J, Poorthuis RB,Mansvelder HD, Fisone G, Ammassari-TeuleM,ArckensL,KriegerP,MeredithR,BagniC.NatCommun.2017Aug17;8(1):293

- Neurons acetylate their way to migration. Borrie SC, Bagni C. EMBO Rep. 2016Dec;17(12):1674-1676.Epub2016Oct21.

Monday29thOctober9:00MatthijsVerhage,PhD(VrijeUniversiteit,Netherlands)MatthijsVerhageobtainedhisPhDattheUniversityofAmsterdamin1990(cumlaude).Hereceivedpost-doctoraltrainingatthelabsofprof.DavidG.Nicholls (Dundee, UK) and the recent Nobel laureate prof. Thomas C.Südhof(HHMI,Dallas,USA).Since2001he is fullprofessorandheadof theDepartmentofFunctionalGenomics at the VUmc and at the Faculty of Life Sciences, VrijeUniversiteit, Amsterdam, The Netherlands. In 2003 he became the firstchairmanoftheCenterforNeurogenomicsandCognitiveResearch(CNCR).He was co-founder and vice chair of the Dutch NeuroBsik Mouse

Phenomicsconsortium.Since2014,heisalsoaffiliatedwiththeKarolinskaInstitutetinStockholm,Sweden(0.1fte)andsince2015alsowiththeBroadInstituteattheMassachusettsInstituteofTechnology(MIT)inBoston,USA(0.1fte).MatthijsVerhagewaspartneroftheEUconsortiumEU-Synapse,vicechairofEuroSpinandSynSys, co-founder and vice chair of H2020 consortium COSYN and founder and coordinator ofSynGO.



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In2013hereceivedtheERCAdvancedGrantoftheEuropeanResearchCouncil.Matthijs Verhage has studied the presynaptic nerve terminal in health and disease for severaldecades.His labcontributed to theelucidationof secretorypathways inmammalianCNSneuronsand synaptic plasticity mechanisms. His team is also involved in studying the role of synapticdysfunctioninencephalopathies,intellectualdisability,autismandschizophrenia.SelectedPublications:

- Poolsizeestimationsfordense-corevesiclesinmammalianCNSneurons.PersoonCM,MoroA,NassalJP,FarinaM,BroekeJH,AroraS,DominguezN,vanWeeringJR,ToonenRF,VerhageM.EMBOJ.2018Oct15;37(20).pii:e99672.

- Vti1a/bregulatesynapticvesicleanddensecorevesiclesecretionviaproteinsortingattheGolgi. Emperador-Melero J, Huson V, vanWeering J, Bollmann C, Fischer vonMollard G,ToonenRF,VerhageM.NatCommun.2018Aug24;9(1):3421.

- Munc13-1andMunc18-1togetherpreventNSF-dependentde-primingofsynapticvesicles.He E, Wierda K, van Westen R, Broeke JH, Toonen RF, Cornelisse LN, Verhage M. NatCommun.2017Jun21;8:15915.

- Asolutiontodependency:usingmultilevelanalysistoaccommodatenesteddata.Aarts E, Verhage M, Veenvliet JV, Dolan CV, van der Sluis S. Nat Neurosci. 2014Apr;17(4):491-6.

Tuesday30thOctober,9:00StephaneOliet(NeurocentreMagendie,France)StéphaneOliet is a neurophysiologistwith a strong interest in synaptictransmission and neuron-glia interactions. He has made somebreakthroughdiscoveries in the fieldofsynapticplasticityanddidsomepioneeredworkon the contributionof astrocytes to synaptic functions.Hewasamongthefirsttoidentifydistinctformsoflong-termdepressionin thehippocampuswhile in the laboratoryofRogerNicoll atUCSF.He

also participated to the demonstration that NMDA-receptor dependent synaptic plasticity wasexpressedpostsynapticallyatCA3-CA1synapses.Hethendescribedtheimportanceoftheastroglialenvironment forglutamatergic transmissionthroughglutamatetransportandgliotransmission.HisgroupinBordeauxhascontributedsignificantlytotheemergingconceptofofthetripartitesynapsethat considers astrocytes as active partners of chemical synapses. In particular, they showed thatastroglial glutamate transporters were key regulators of synaptic efficacy through the control ofpresynaptic metabotropic receptors activity. He also demonstrated that membrane trafficking ofthesereceptorsatthesurfaceofastrocyteswasessentialforensuringanefficientglutamateuptake.His group also focused on the ability of astrocytes to supply synaptic NMDA receptors with anendogenous co-agonist, D-serine. Through this process, astrocytes gate hippocampal NMDAR-dependent plasticity and thus play a role in learning and memory. His interest in glia cells nowextendedtopathologicalsituationincludingcognitivedeficitassociatedwithAlzheimerdiseaseandmoregenerallyneuroinflammation.Stephane Oliet is the acting director of the NeurocentreMagendie, an Inserm Research Institutewhich is part of Bordeaux Neurocampus. This Institute is composed of about 200 persons, 11researchteams,and6technicalplatforms.Selectedpublications:

- Astroglial CB1Receptors Determine Synaptic D-Serine Availability to Enable RecognitionMemory.RobinLM,OliveiradaCruzJF,LanglaisVC,Martin-FernandezM,Metna-LaurentM,Busquets-Garcia A, Bellocchio L, Soria-Gomez E, Papouin T, Varilh M, Sherwood MW,



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Belluomo I,BalcellsG,Matias I,BosierB,DragoF,VanEeckhautA,Smolders I,GeorgesF,AraqueA,PanatierA,OlietSHR,MarsicanoG.Neuron.2018Jun6;98(5):935-944.e5.

- Co-agonistsdifferentiallytuneGluN2B-NMDAreceptortraffickingathippocampalsynapses.Ferreira JS, Papouin T, Ladépêche L, Yao A, Langlais VC, Bouchet D, Dulong J,Mothet JP,SacchiS,PollegioniL,PaolettiP,OlietSHR,GrocL.Elife.2017Jun9;6.pii:e25492.

- Surfacediffusionofastrocyticglutamatetransportersshapessynaptictransmission.Murphy-RoyalC,DupuisJP,VarelaJA,PanatierA,PinsonB,BaufretonJ,GrocL,OlietSH.NatNeurosci.2015Feb;18(2):219-26.

- Gliotransmitters travel in time and space. Araque A, Carmignoto G, Haydon PG, Oliet SH,RobitailleR,VolterraA.Neuron.2014Feb19;81(4):728-39.

cajal atsb keynote speakers - fens.org files/cajal/2019... · later he got recruited to vib leuven...

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