c teratoma
DESCRIPTION
http://www.dnbpediatrics.com/TRANSCRIPT
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CONGENITAL CERVICAL TERATOMA
Ajay Agade
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CASE REPORT
1 day old neonate
Antenatal History of anterior neck swelling
Confirmed postnatally
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ANTENATAL COURSE
Maternal age 26 years
Second gravida with one alive child
Previous LSCS
No other significant Medical/Surgical issues Regular follow up while in Antenatal period
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ANTENATAL ASSESSMENT
Clinical assessments normal
Fetus has large neck mass on USG in 37th week
Mild Polyhydramnios
Antenatal diagnosis was cystic hygroma
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ANTENATAL ULTRASOUND
11.01.2011
Fetus with vertical lie
Cephalic presentation
No abnormality detected
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ANTENATAL ULTRASOUND
8.03.2011
Well defined hypo echoic mass
Dimensions 5.5 X 6 cm
located in cervical region
Lateral to neck vessels
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ANTENATAL MANAGMENT
Guarded prognosis was explained
Continuation of pregnancy was advised
Mode of delivery was to be decided upon obstetric indications
Antenatal procedures not feasible
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LABOUR ROOM ASSESSMENT
FTLSCS at JLNHRC on 19/3/2011 12:50 pm
Baby had massive neck mass
Cried immediately after birth
Had mild respiratory distress in supine position
APGAR score at 1 min – 7 5 min - 8
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LABOUR ROOM MANAGMENT Birth of high risk newborn anticipated
Instruments for securing airways were ready had the baby deteriorated further
Kept in thermo neutral environment
Dried and wrapped in warm clothing's
Oro-nasal suctioning were performed
Distress was alleviated in right lateral position
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TRANSPORTATION
Initial stabilization assured in labour room
Necessary equipments kept ready in NICU
Transported with warm clothes
Airway positioning while transporting assured
Case was informed to pediatric surgeon
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NICU ASSESSMENT-VITALS
› Euthermic
› No other dysmorphic features
› CRT < 2 sec
› Heart rate 122/min
› Respiratory Rate 40/min
› BP 58/32 (40) mm Hg
› Anthropometry
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NICU ASSESSMENT-SYSTEMIC
› Respiratory system - B/L breath sounds distinct equally heard
conducted sounds + Inspiratory stridor
› CVS – S1S2 +, no murmurs
› Per Abdomen – soft, non distended, non tender
› CNS – NNR present
› Ext genital – female, normal
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NICU ASSESSMENT-LOCAL
› Solitary neck mass
› Large –10x8x6 cms
› Midline, encroaching towards right
› Non pulsatile
› Skin - normal
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Palpation confirmed the findings
Temp – normal
Tenderness – absent
firm to hard mass
Not compressible
Well encapsulated
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Mobile in all the directions
Not adherent to underlying structures
Not adherent to skin
Trans illumination- absent
Not pulsatile
No thrills or hum
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NICU MANAGMENT
Thermo neutral environment with servo control
Airways management and positioning
Fluid and electrolyte
Nutrition
Respiratory and Hemodynamic monitoring
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DIFFERENTIAL DIAGNOSIS
› Tense cystic hygroma
› Teratoma
› Hemangioma
› Neuorblastoma
› Rhabdomyosarcoma
› Rarer conditions Congenital thymic cyst Congenital goitre Branchial cleft cyst
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BEDSIDE USG NECK
› Solid mass
› Well encapsulated
› Few areas of cystic degeneration
› Few stipulated calcifications
› No large calibre vessels inside the tumor
› Neck vessels pushed laterally
› Tracheal displacement +
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ENT consultation
› airway status › need of elective/emergent intubation› Intra operative help
ENT Opinion
› No pressure effect on trachea› No need of emergent intubation› CT scan› FNAC
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FNAC avoided due to
› possible risk of hemorrhage within the mass leading to airway compromise.
› Non representative areas aspirated
› Limited sensitivity of FNAC
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CT SCAN NECK WITH THORAX
› Origin
› extent
› compression effects
› associated malformations.
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C.T NECK AND THORAX
Localisation of mass Characterisation of nature of lesion Airway column assesment Relationship with major neck vessels
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CT NECK AND THORAX
3 mm section thickness plain and post contrast
Base of skull to diaphragm
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LARGE HETEROGENOUS MASS WITH NODULAR CALCIFICATIONS
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LT THYROID GLAND SEEN
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POSTCONTRAST SCAN SHOWS DISPLACEMENT OF PAROTID GLAND AND
MAJOR VESSELS
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WELL ENCAPSULATED NOT INVOLVING SKIN
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NO INTRATHORACIC EXTENSION
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CORONAL RECONSTRUCTION C.T
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C.T scan findings
A large 6.5x6x5 cm sized heterogenous Mildly enhancing mass lesion wnich is well
encapsulated containing scattered nodular calcification seen involving neck anteriorly and on rt side
Supreiorly upto submandibular space Inferiorly supraclavicular region Displacing airway column on left and major
vessels posteriorly possibility of cervical teratoma.To be correlated with clinical and histopathological findings
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TUMOUR MARKER ASSAY
Serum alpha feto-protein on day 2- 83,000 ng/ml
Normal range = 100000 to 125 ng/ml from neonatal to infancy
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PROVISIONAL DIAGNOSIS
› Clinical findings - solid mass
› USG - Non vascular
› CT - Heterogenous - Calcification
› Raised AFP
Cervical Teratoma
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TREATMENT PLAN
› Primary Surgical excision
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ANAESTHESIA
Airway assessment
General anaesthesia
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AIRWAY ASSESSMENT
Direct larngoscopy Difficult airway
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ENDOTRACHEAL INTUBATION
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POSITION
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INCISION
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DISSECTION
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PREOP POSTOP
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HPE REPORT
Immature cervical teratoma , grade 2
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GROSS SPECIMEN
Specimen of
6.5x6x3.5 cm
received.
O/S- nodular with
retracted capsule.
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GROSS SPECIMEN C/S- shows lobulated grey white
mass predominantly solid with
multiple small cysts .
Cysts are of varying size from
1mm to1cm diameter filled with
mucinous material.
Few cartilagenous area, slimy
area & bony spicules were
present in solid part of the
mass.
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H&E STAIN 40XMature cartilage
H&E STAIN 10XImmature cartilage
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H&E STAIN 10X RESPIRATORY EPITHLIAL CLEFT WITH LINING
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H&E STAIN 10X SQUAMOUS EPITHELIUM WITH KERATINIZATION
H&E STAIN 10X NESTS OF IMMATURE SQUAMOUS EPITHELIUM
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H&E STAIN 10X IMMATURE NEURAL EPITHELIUM
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H&E STAIN 10X BLASTEMAL CELLS
H& E STAIN BLASTEMAL CELLS
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H & E STAIN 20X MUCIN PRODUCING GLANDS
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Microscopic examination
• Multiple sections studied from tumour shows mature as
well as immature elements derived from all 3 germ layers.
• Mature elements comprise of nests of squamous cells,
glands, mature cartilage, occasional bony tissue, neural
tissue & smooth muscle tissue.
• Immature elements include neuroepithelial elements,
occasional group of blastemal cells & immature cartilage in
myxoid stroma. Mitosis is in the range of 2/10HPF. Normal
thyroid tissue is not seen in the section studied.
• Impression:- ABOVE FEATURES FAVOUR IMMATURE CERVICAL TERATOMA (Grade –II)
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HISTOLOGICAL GRADING OF IMMATURE TERATOMA
0 Mature solid teratoma
I Abundance of mature tissues, intermixed with loose mesenchymal tissue with occasional mitoses; immature cartilage; tooth anlage
II Fewer mature tissues; rare foci of neuroepithelium with common mitoses, not exceeding three 40X fields in any one slide
III Few or no mature tissue ; numerous neuroepithelial elements, merging with a cellular stroma occupying ≥four 40X fields
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WHAT IS TERATOMA? Greek word – monstrous tumour
Derived from all three embryonic germ layers-ectoderm, endoderm and mesoderm
Can occur anywhere in the body
Most common location – sacral region
Rarer in adults since most are detected in childhood.
Neonatal period are uncommon and virtually always benign
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CERVICAL TERATOMA
Rare congenital tumours of neck
Challenging in the neonatal period
Present as massive neck swelling with airway compression
High perinatal mortality and morbidity rates.
Predominantly of the mature variety
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CERVICAL TERATOMA
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WHAT IS THE INCIDENCE OF CERVICAL TERATOMA?
Constitute 1.6 to 9.3% of pediatric teratomas, 1per 40,000 births
Global scenario - Over 150 cases reported so far
Indian scenario - 4 cases ,1stiiborn, 1 died soon after birth, 2 surviving
No apparent relationship to the mother's age
No greater odds of occurance in males versus females
No racial or ethnic preference.
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WHAT CAUSES CERVICAL TERATOMA?
Exact cause still unknown
Inability of totipotent cells to differentiate into a complete body or organ
Abnormal development of a conjoined twin
Arises from stem cells within the thyroid gland
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PROBABLE GENETIC FACTORS
Novel karyotypic changes on comparative genomic hybridization
› 1p21.1 amplification
› 9p22 deletion
› 17q21.33 1-copy gain
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ASSOCIATED ANOMALIES
Rare
› Imperforate anus
› Chondrodystrophia fetalis,
› Hypoplastic left ventricle with pulmonary
hypoplasia,
› Cystic fibrosis,
› Absence of corpus callosum,
› Arachanoid cyst
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CLASSIFICATION
Based on birth status, age at diagnosis, and the presence or absence of respiratory distress.
› Group I--stillborn and moribund live newborns
› Group II--newborn with respiratory distress
› Group III--newborn without respiratory distress
› Group IV--children age 1 month to 18 years
› Group V--adults
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IS CLINICAL DIFFERENTIATION
POSSIBLE? Physical Examination
› Size› Multiplicity› Laterality› Consistency› Color› Mobility› Tenderness› Fluctuation› Transillumination test
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MOST IMPORTANT IS LOCATION.
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LYMPHANGIOMA (CYSTIC HYGROMA)
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HAEMANGIOMA
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BRANCHIAL CLEFT CYST
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THYROGLOSSAL CYST
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DERMOID CYST
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THYMIC CYST
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HOW IS CERVICAL TERATOMA DIAGNOSED ANTENATALLY?
USG
MRI
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ANTENATAL USG
Ultrasound – best modality
Asymmetric, well-defined
masses
Large and bulky.
Calcifications
Polyhydramnios in 20 to 40
percent cases
Other fetal abnormalities +
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ANTENATAL MRI
Shows mediastinal
involvement
position of the
airway.
Partial / total
Compression
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What are the Fetal Interventions for Cervical Teratoma?
Ex utero intrapartum
treatment (EXIT)
procedure / OOPS
procedure
Specifically designed to
preserve uteroplacental
gas exchange to provide
time to secure the airway
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EXIT PROCEDURE
provides time for:
› Neck dissection
› Clip removal
› Bronchoscopy
› Endotracheal intubation
› Surfactant administration
› Placement of umbilical arterial and venous
catheters
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HOW IS PREGNANCY MANAGED WHEN CERVICAL TERATOMA IS DIAGNOSED?
Frequent ANCs Frequent ultrasound exams
recommended to monitor› amniotic fluid volume, › tumor size, › growth and the general health of the fetus
Institutional delivery encouraged Elective cesarean preferred Team approach for ex utero management
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HOW TO INVESTIGATE ?
Baseline hemogram and blood biochemistry
USG
CT scan/MRI
FNAC and Biopsy
Thyroid and parathyroid function test
Serum alpha fetoprotien and beta HCG
Transcription factors GATA-4 and GATA-6
Genetic studies
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POSTNATAL MANAGEMENT
Expedient multidisciplinary approach
› Airway management
› Definitive management
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WHAT ARE TREATMENT OPTIONS FOR THE NEWBORN?
Primary surgical excision
If malignancy proved then
› Chemotherapy
› Radiotherapy
› Combination therapy
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WHAT IS THE LONG-TERM OUTCOME WITH CERVICAL TERATOMA?
Risk for serious thyroid conditions
› Hypoparathyroidisim
› Hypothyroidism
Developmental delay and mental
retardation
Malignant transformation
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Recurrence
Metastasize to regional lymph nodes
Occurring among siblings (only one
case reported)
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Follow up
Recommendations › AFP levels be obtained
at birth at 1month, three-month intervals in infancy and yearly thereafter, upto 3 years of life
› MRI scanning twice a year for the first three years of life.
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PROGNOSIS
Airway obstruction at birth
Degree of maturity of tissues Completeness of resection
Associated anomalies
Mortality is high in untreated infants & low if treated surgically
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MULTIDISCIPLINARY TEAM APPROACH