brain basics - understanding sleep
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Brain Basics - Understanding SleepTRANSCRIPT
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24/01/2015 BrainBasics:UnderstandingSleep:NationalInstituteofNeurologicalDisordersandStroke(NINDS)
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BrainBasics:UnderstandingSleep
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Doyoueverfeelsleepyor"zoneout"duringtheday?DoyoufindithardtowakeuponMondaymornings?Ifso,youarefamiliarwiththepowerfulneedforsleep.However,youmaynotrealizethatsleepisasessentialforyourwellbeingasfoodandwater.
Sleep:ADynamicActivityHowMuchSleepDoWeNeed?WhatDoesSleepDoForUs?DreamingandREMSleepSleepandCircadianRhythmsSleepandDiseaseSleepDisordersTheFutureTipsforaGoodNight'sSleep
Sleep:ADynamicActivity
Untilthe1950s,mostpeoplethoughtofsleepasapassive,dormantpartofourdailylives.Wenowknowthatourbrainsareveryactiveduringsleep.Moreover,sleepaffectsourdailyfunctioningandourphysicalandmentalhealthinmanywaysthatwearejustbeginningtounderstand.
Nervesignalingchemicalscalledneurotransmitterscontrolwhetherweareasleeporawakebyactingondifferentgroupsofnervecells,orneurons,inthebrain.Neuronsinthebrainstem,whichconnectsthebrainwiththespinalcord,produceneurotransmitterssuchasserotoninandnorepinephrinethatkeepsomepartsofthebrainactivewhileweareawake.Otherneuronsatthebaseofthebrainbeginsignalingwhenwefallasleep.Theseneuronsappearto"switchoff"thesignalsthatkeepusawake.Researchalsosuggeststhatachemicalcalledadenosinebuildsupinourbloodwhileweareawakeandcausesdrowsiness.Thischemicalgraduallybreaksdownwhilewesleep.
Duringsleep,weusuallypassthroughfivephasesofsleep:stages1,2,3,4,andREM(rapideyemovement)sleep.Thesestagesprogressinacyclefromstage1toREMsleep,thenthecyclestartsoveragainwithstage1(seefigure1).Wespendalmost50percentofourtotalsleeptimeinstage2sleep,about20percentinREMsleep,andtheremaining30percentintheotherstages.Infants,bycontrast,spendabouthalfoftheirsleeptimeinREMsleep.
Duringstage1,whichislightsleep,wedriftinandoutofsleepandcanbeawakenedeasily.Oureyesmoveveryslowlyandmuscleactivityslows.Peopleawakenedfromstage1sleepoftenrememberfragmentedvisualimages.Manyalsoexperiencesuddenmusclecontractionscalledhypnicmyoclonia,oftenprecededbyasensationofstartingtofall.Thesesuddenmovementsaresimilartothe"jump"wemakewhenstartled.Whenweenterstage2sleep,oureyemovementsstopandourbrainwaves(fluctuationsof
DisordersAZ:ABCDEFGHIJKLMNOPQRSTUVWXYZ
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electricalactivitythatcanbemeasuredbyelectrodes)becomeslower,withoccasionalburstsofrapidwavescalledsleepspindles.Instage3,extremelyslowbrainwavescalleddeltawavesbegintoappear,interspersedwithsmaller,fasterwaves.Bystage4,thebrainproducesdeltawavesalmostexclusively.Itisverydifficulttowakesomeoneduringstages3and4,whichtogetherarecalleddeepsleep.Thereisnoeyemovementormuscleactivity.Peopleawakenedduringdeepsleepdonotadjustimmediatelyandoftenfeelgroggyanddisorientedforseveralminutesaftertheywakeup.Somechildrenexperiencebedwetting,nightterrors,orsleepwalkingduringdeepsleep.
WhenweswitchintoREMsleep,ourbreathingbecomesmorerapid,irregular,andshallow,oureyesjerkrapidlyinvariousdirections,andourlimbmusclesbecometemporarilyparalyzed.Ourheartrateincreases,ourbloodpressurerises,andmalesdeveloppenileerections.WhenpeopleawakenduringREMsleep,theyoftendescribebizarreandillogicaltalesdreams.
ThefirstREMsleepperiodusuallyoccursabout70to90minutesafterwefallasleep.Acompletesleepcycletakes90to110minutesonaverage.ThefirstsleepcycleseachnightcontainrelativelyshortREMperiodsandlongperiodsofdeepsleep.Asthenightprogresses,REMsleepperiodsincreaseinlengthwhiledeepsleepdecreases.Bymorning,peoplespendnearlyalltheirsleeptimeinstages1,2,andREM.
Peopleawakenedaftersleepingmorethanafewminutesareusuallyunabletorecallthelastfewminutesbeforetheyfellasleep.Thissleeprelatedformofamnesiaisthereasonpeopleoftenforgettelephonecallsorconversationsthey'vehadinthemiddleofthenight.Italsoexplainswhyweoftendonotrememberouralarmsringinginthemorningifwegorightbacktosleepafterturningthemoff.
Sincesleepandwakefulnessareinfluencedbydifferentneurotransmittersignalsinthebrain,foodsandmedicinesthatchangethebalanceofthesesignalsaffectwhetherwefeelalertordrowsyandhowwellwesleep.Caffeinateddrinkssuchascoffeeanddrugssuchasdietpillsanddecongestantsstimulatesomepartsofthebrainandcancauseinsomnia,oraninabilitytosleep.ManyantidepressantssuppressREMsleep.HeavysmokersoftensleepverylightlyandhavereducedamountsofREMsleep.Theyalsotendtowakeupafter3or4hoursofsleepduetonicotinewithdrawal.Manypeoplewhosufferfrominsomniatrytosolvetheproblemwithalcoholthesocallednightcap.Whilealcoholdoeshelppeoplefallintolightsleep,italsorobsthemofREMandthedeeper,morerestorativestagesofsleep.Instead,itkeepstheminthelighterstagesofsleep,fromwhichtheycanbeawakenedeasily.
PeoplelosesomeoftheabilitytoregulatetheirbodytemperatureduringREM,soabnormallyhotorcoldtemperaturesintheenvironmentcandisruptthisstageofsleep.IfourREMsleepisdisruptedonenight,ourbodiesdon'tfollowthenormalsleepcycleprogressionthenexttimewedozeoff.Instead,weoftenslipdirectlyintoREMsleepandgothroughextendedperiodsofREMuntilwe"catchup"onthisstageofsleep.
Peoplewhoareunderanesthesiaorinacomaareoftensaidtobeasleep.However,peopleintheseconditionscannotbeawakenedanddonotproducethecomplex,activebrainwavepatternsseeninnormalsleep.Instead,theirbrainwavesareveryslowandweak,sometimesallbutundetectable.
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HowMuchSleepDoWeNeed?
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Theamountofsleepeachpersonneedsdependsonmanyfactors,includingage.Infantsgenerallyrequireabout16hoursaday,whileteenagersneedabout9hoursonaverage.Formostadults,7to8hoursanightappearstobethebestamountofsleep.Womeninthefirst3monthsofpregnancyoftenneedseveralmorehoursofsleepthanusual.Theamountofsleepapersonneedsalsoincreasesifheorshehasbeendeprivedofsleepinpreviousdays.Gettingtoolittlesleepcreatesa"sleepdebt,"whichismuchlikebeingoverdrawnatabank.Eventually,yourbodywilldemandthatthedebtberepaid.Wedon'tseemtoadapttogettinglesssleepthanweneedwhilewemaygetusedtoasleepdeprivingschedule,ourjudgment,reactiontime,andotherfunctionsarestillimpaired.
Peopletendtosleepmorelightlyandforshortertimespansastheygetolder,althoughtheygenerallyneedaboutthesameamountofsleepastheyneededinearlyadulthood.Abouthalfofallpeopleover65havefrequentsleepingproblems,suchasinsomnia,anddeepsleepstagesinmanyelderlypeopleoftenbecomeveryshortorstopcompletely.Thischangemaybeanormalpartofaging,oritmayresultfrommedicalproblemsthatarecommoninelderlypeopleandfromthemedicationsandothertreatmentsforthoseproblems.
Expertssaythatifyoufeeldrowsyduringtheday,evenduringboringactivities,youhaven'thadenoughsleep.Ifyouroutinelyfallasleepwithin5minutesoflyingdown,youprobablyhaveseveresleepdeprivation,possiblyevenasleepdisorder.Microsleeps,orverybriefepisodesofsleepinanotherwiseawakeperson,areanothermarkofsleepdeprivation.Inmanycases,peoplearenotawarethattheyareexperiencingmicrosleeps.Thewidespreadpracticeof"burningthecandleatbothends"inwesternindustrializedsocietieshascreatedsomuchsleepdeprivationthatwhatisreallyabnormalsleepinessisnowalmostthenorm.
Manystudiesmakeitclearthatsleepdeprivationisdangerous.Sleepdeprivedpeoplewhoaretestedbyusingadrivingsimulatororbyperformingahandeyecoordinationtaskperformasbadlyasorworsethanthosewhoareintoxicated.Sleepdeprivationalsomagnifiesalcohol'seffectsonthebody,soafatiguedpersonwhodrinkswillbecomemuchmoreimpairedthansomeonewhoiswellrested.Driverfatigueisresponsibleforanestimated100,000motorvehicleaccidentsand1500deathseachyear,accordingtotheNationalHighwayTrafficSafetyAdministration.Sincedrowsinessisthebrain'slaststepbeforefallingasleep,drivingwhiledrowsycanandoftendoesleadtodisaster.Caffeineandotherstimulantscannotovercometheeffectsofseveresleepdeprivation.TheNationalSleepFoundationsaysthatifyouhavetroublekeepingyoureyesfocused,ifyoucan'tstopyawning,orifyoucan'trememberdrivingthelastfewmiles,youareprobablytoodrowsytodrivesafely.
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WhatDoesSleepDoForUs?
Althoughscientistsarestilltryingtolearnexactlywhypeopleneedsleep,animalstudiesshowthatsleepisnecessaryforsurvival.Forexample,whileratsnormallylivefortwotothreeyears,thosedeprivedofREMsleepsurviveonlyabout5weeksonaverage,andratsdeprivedofallsleepstagesliveonlyabout3weeks.Sleepdeprivedratsalsodevelopabnormallylowbodytemperaturesandsoresontheirtailandpaws.Thesoresmaydevelopbecausetherats'immunesystemsbecomeimpaired.Somestudiessuggestthatsleepdeprivationaffectstheimmunesystemindetrimentalways.
Sleepappearsnecessaryforournervoussystemstoworkproperly.Toolittlesleepleavesusdrowsyandunabletoconcentratethenextday.Italsoleadstoimpairedmemoryand
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physicalperformanceandreducedabilitytocarryoutmathcalculations.Ifsleepdeprivationcontinues,hallucinationsandmoodswingsmaydevelop.Someexpertsbelievesleepgivesneuronsusedwhileweareawakeachancetoshutdownandrepairthemselves.Withoutsleep,neuronsmaybecomesodepletedinenergyorsopollutedwithbyproductsofnormalcellularactivitiesthattheybegintomalfunction.Sleepalsomaygivethebrainachancetoexerciseimportantneuronalconnectionsthatmightotherwisedeterioratefromlackofactivity.
Deepsleepcoincideswiththereleaseofgrowthhormoneinchildrenandyoungadults.Manyofthebody'scellsalsoshowincreasedproductionandreducedbreakdownofproteinsduringdeepsleep.Sinceproteinsarethebuildingblocksneededforcellgrowthandforrepairofdamagefromfactorslikestressandultravioletrays,deepsleepmaytrulybe"beautysleep."Activityinpartsofthebrainthatcontrolemotions,decisionmakingprocesses,andsocialinteractionsisdrasticallyreducedduringdeepsleep,suggestingthatthistypeofsleepmayhelppeoplemaintainoptimalemotionalandsocialfunctioningwhiletheyareawake.Astudyinratsalsoshowedthatcertainnervesignalingpatternswhichtheratsgeneratedduringthedaywererepeatedduringdeepsleep.Thispatternrepetitionmayhelpencodememoriesandimprovelearning.
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DreamingandREMSleep
Wetypicallyspendmorethan2hourseachnightdreaming.Scientistsdonotknowmuchabouthoworwhywedream.SigmundFreud,whogreatlyinfluencedthefieldofpsychology,believeddreamingwasa"safetyvalve"forunconsciousdesires.Onlyafter1953,whenresearchersfirstdescribedREMinsleepinginfants,didscientistsbegintocarefullystudysleepanddreaming.Theysoonrealizedthatthestrange,illogicalexperienceswecalldreamsalmostalwaysoccurduringREMsleep.WhilemostmammalsandbirdsshowsignsofREMsleep,reptilesandothercoldbloodedanimalsdonot.
REMsleepbeginswithsignalsfromanareaatthebaseofthebraincalledthepons(seefigure2).Thesesignalstraveltoabrainregioncalledthethalamus,whichrelaysthemtothecerebralcortextheouterlayerofthebrainthatisresponsibleforlearning,thinking,andorganizinginformation.Theponsalsosendssignalsthatshutoffneuronsinthespinalcord,causingtemporaryparalysisofthelimbmuscles.Ifsomethinginterfereswiththisparalysis,peoplewillbegintophysically"actout"theirdreamsarare,dangerousproblemcalledREMsleepbehaviordisorder.Apersondreamingaboutaballgame,forexample,mayrunheadlongintofurnitureorblindlystrikesomeonesleepingnearbywhiletryingtocatchaballinthedream.
REMsleepstimulatesthebrainregionsusedinlearning.Thismaybeimportantfornormalbraindevelopmentduringinfancy,whichwouldexplainwhyinfantsspendmuchmoretimeinREMsleepthanadults(seeSleep:ADynamicActivity).Likedeepsleep,REMsleepisassociatedwithincreasedproductionofproteins.OnestudyfoundthatREMsleepaffectslearningofcertainmentalskills.PeopletaughtaskillandthendeprivedofnonREMsleepcouldrecallwhattheyhadlearnedaftersleeping,whilepeopledeprivedofREMsleepcouldnot.
Somescientistsbelievedreamsarethecortex'sattempttofindmeaningintherandomsignalsthatitreceivesduringREMsleep.Thecortexisthepartofthebrainthatinterpretsandorganizesinformationfromtheenvironmentduringconsciousness.Itmaybethat,givenrandomsignalsfromtheponsduringREMsleep,thecortextriestointerpretthese
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signalsaswell,creatinga"story"outoffragmentedbrainactivity.
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SleepandCircadianRhythms
Circadianrhythmsareregularchangesinmentalandphysicalcharacteristicsthatoccurinthecourseofaday(circadianisLatinfor"aroundaday").Mostcircadianrhythmsarecontrolledbythebody'sbiological"clock."Thisclock,calledthesuprachiasmaticnucleusorSCN(seefigure2),isactuallyapairofpinheadsizedbrainstructuresthattogethercontainabout20,000neurons.TheSCNrestsinapartofthebraincalledthehypothalamus,justabovethepointwheretheopticnervescross.Lightthatreachesphotoreceptorsintheretina(atissueatthebackoftheeye)createssignalsthattravelalongtheopticnervetotheSCN.
SignalsfromtheSCNtraveltoseveralbrainregions,includingthepinealgland,whichrespondstolightinducedsignalsbyswitchingoffproductionofthehormonemelatonin.Thebody'slevelofmelatoninnormallyincreasesafterdarknessfalls,makingpeoplefeeldrowsy.TheSCNalsogovernsfunctionsthataresynchronizedwiththesleep/wakecycle,includingbodytemperature,hormonesecretion,urineproduction,andchangesinbloodpressure.
Bydeprivingpeopleoflightandotherexternaltimecues,scientistshavelearnedthatmostpeople'sbiologicalclocksworkona25hourcycleratherthana24hourone.ButbecausesunlightorotherbrightlightscanresettheSCN,ourbiologicalcyclesnormallyfollowthe24hourcycleofthesun,ratherthanourinnatecycle.Circadianrhythmscanbeaffectedtosomedegreebyalmostanykindofexternaltimecue,suchasthebeepingofyouralarmclock,theclatterofagarbagetruck,orthetimingofyourmeals.Scientistscallexternaltimecueszeitgebers(Germanfor"timegivers").
Whentravelerspassfromonetimezonetoanother,theysufferfromdisruptedcircadianrhythms,anuncomfortablefeelingknownasjetlag.Forinstance,ifyoutravelfromCaliforniatoNewYork,you"lose"3hoursaccordingtoyourbody'sclock.Youwillfeeltiredwhenthealarmringsat8a.m.thenextmorningbecause,accordingtoyourbody'sclock,itisstill5a.m.Itusuallytakesseveraldaysforyourbody'scyclestoadjusttothenewtime.
Toreducetheeffectsofjetlag,somedoctorstrytomanipulatethebiologicalclockwithatechniquecalledlighttherapy.Theyexposepeopletospeciallights,manytimesbrighterthanordinaryhouseholdlight,forseveralhoursnearthetimethesubjectswanttowakeup.Thishelpsthemresettheirbiologicalclocksandadjusttoanewtimezone.
Symptomsmuchlikejetlagarecommoninpeoplewhoworknightsorwhoperformshiftwork.Becausethesepeople'sworkschedulesareatoddswithpowerfulsleepregulatingcueslikesunlight,theyoftenbecomeuncontrollablydrowsyduringwork,andtheymaysufferinsomniaorotherproblemswhentheytrytosleep.Shiftworkershaveanincreasedriskofheartproblems,digestivedisturbances,andemotionalandmentalproblems,allofwhichmayberelatedtotheirsleepingproblems.Thenumberandseverityofworkplaceaccidentsalsotendtoincreaseduringthenightshift.MajorindustrialaccidentsattributedpartlytoerrorsmadebyfatiguednightshiftworkersincludetheExxonValdezoilspillandtheThreeMileIslandandChernobylnuclearpowerplantaccidents.Onestudyalsofoundthatmedicalinternsworkingonthenightshiftaretwiceaslikelyasotherstomisinterprethospitaltestrecords,whichcouldendangertheirpatients.Itmaybepossibletoreduceshiftrelatedfatiguebyusingbrightlightsintheworkplace,minimizingshiftchanges,and
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takingschedulednaps.
Manypeoplewithtotalblindnessexperiencelifelongsleepingproblemsbecausetheirretinasareunabletodetectlight.Thesepeoplehaveakindofpermanentjetlagandperiodicinsomniabecausetheircircadianrhythmsfollowtheirinnatecycleratherthana24hourone.Dailysupplementsofmelatoninmayimprovenighttimesleepforsuchpatients.However,sincethehighdosesofmelatoninfoundinmostsupplementscanbuildupinthebody,longtermuseofthissubstancemaycreatenewproblems.Becausethepotentialsideeffectsofmelatoninsupplementsarestilllargelyunknown,mostexpertsdiscouragemelatoninusebythegeneralpublic.
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SleepandDisease
Sleepandsleeprelatedproblemsplayaroleinalargenumberofhumandisordersandaffectalmosteveryfieldofmedicine.Forexample,problemslikestrokeandasthmaattackstendtooccurmorefrequentlyduringthenightandearlymorning,perhapsduetochangesinhormones,heartrate,andothercharacteristicsassociatedwithsleep.Sleepalsoaffectssomekindsofepilepsyincomplexways.REMsleepseemstohelppreventseizuresthatbegininonepartofthebrainfromspreadingtootherbrainregions,whiledeepsleepmaypromotethespreadoftheseseizures.Sleepdeprivationalsotriggersseizuresinpeoplewithsometypesofepilepsy.
Neuronsthatcontrolsleepinteractcloselywiththeimmunesystem.Asanyonewhohashadthefluknows,infectiousdiseasestendtomakeusfeelsleepy.Thisprobablyhappensbecausecytokines,chemicalsourimmunesystemsproducewhilefightinganinfection,arepowerfulsleepinducingchemicals.Sleepmayhelpthebodyconserveenergyandotherresourcesthattheimmunesystemneedstomountanattack.
Sleepingproblemsoccurinalmostallpeoplewithmentaldisorders,includingthosewithdepressionandschizophrenia.Peoplewithdepression,forexample,oftenawakenintheearlyhoursofthemorningandfindthemselvesunabletogetbacktosleep.Theamountofsleepapersongetsalsostronglyinfluencesthesymptomsofmentaldisorders.Sleepdeprivationisaneffectivetherapyforpeoplewithcertaintypesofdepression,whileitcanactuallycausedepressioninotherpeople.Extremesleepdeprivationcanleadtoaseeminglypsychoticstateofparanoiaandhallucinationsinotherwisehealthypeople,anddisruptedsleepcantriggerepisodesofmania(agitationandhyperactivity)inpeoplewithmanicdepression.
Sleepingproblemsarecommoninmanyotherdisordersaswell,includingAlzheimer'sdisease,stroke,cancer,andheadinjury.Thesesleepingproblemsmayarisefromchangesinthebrainregionsandneurotransmittersthatcontrolsleep,orfromthedrugsusedtocontrolsymptomsofotherdisorders.Inpatientswhoarehospitalizedorwhoreceiveroundtheclockcare,treatmentschedulesorhospitalroutinesalsomaydisruptsleep.Theoldjokeaboutapatientbeingawakenedbyanursesohecouldtakeasleepingpillcontainsagrainoftruth.Oncesleepingproblemsdevelop,theycanaddtoaperson'simpairmentandcauseconfusion,frustration,ordepression.Patientswhoareunabletosleepalsonoticepainmoreandmayincreasetheirrequestsforpainmedication.Bettermanagementofsleepingproblemsinpeoplewhohaveotherdisorderscouldimprovethesepatients'healthandqualityoflife.
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SleepDisorders
Atleast40millionAmericanseachyearsufferfromchronic,longtermsleepdisorderseachyear,andanadditional20millionexperienceoccasionalsleepingproblems.Thesedisordersandtheresultingsleepdeprivationinterferewithwork,driving,andsocialactivities.Theyalsoaccountforanestimated$16billioninmedicalcostseachyear,whiletheindirectcostsduetolostproductivityandotherfactorsareprobablymuchgreater.Doctorshavedescribedmorethan70sleepdisorders,mostofwhichcanbemanagedeffectivelyoncetheyarecorrectlydiagnosed.Themostcommonsleepdisordersincludeinsomnia,sleepapnea,restlesslegssyndrome,andnarcolepsy.
InsomniaSleepApneaRestlessLegsSyndromeNarcolepsy
Insomnia
Almosteveryoneoccasionallysuffersfromshortterminsomnia.Thisproblemcanresultfromstress,jetlag,diet,ormanyotherfactors.Insomniaalmostalwaysaffectsjobperformanceandwellbeingthenextday.About60millionAmericansayearhaveinsomniafrequentlyorforextendedperiodsoftime,whichleadstoevenmoreserioussleepdeficits.Insomniatendstoincreasewithageandaffectsabout40percentofwomenand30percentofmen.Itisoftenthemajordisablingsymptomofanunderlyingmedicaldisorder.
Forshortterminsomnia,doctorsmayprescribesleepingpills.Mostsleepingpillsstopworkingafterseveralweeksofnightlyuse,however,andlongtermusecanactuallyinterferewithgoodsleep.Mildinsomniaoftencanbepreventedorcuredbypracticinggoodsleephabits(see"TipsforaGoodNight'sSleep").Formoreseriouscasesofinsomnia,researchersareexperimentingwithlighttherapyandotherwaystoaltercircadiancycles.
SleepApnea
Sleepapneaisadisorderofinterruptedbreathingduringsleep.Itusuallyoccursinassociationwithfatbuilduporlossofmuscletonewithaging.Thesechangesallowthewindpipetocollapseduringbreathingwhenmusclesrelaxduringsleep(seefigure3).Thisproblem,calledobstructivesleepapnea,isusuallyassociatedwithloudsnoring(thoughnoteveryonewhosnoreshasthisdisorder).Sleepapneaalsocanoccuriftheneuronsthatcontrolbreathingmalfunctionduringsleep.
Duringanepisodeofobstructiveapnea,theperson'sefforttoinhaleaircreatessuctionthatcollapsesthewindpipe.Thisblockstheairflowfor10secondstoaminutewhilethesleepingpersonstrugglestobreathe.Whentheperson'sbloodoxygenlevelfalls,thebrainrespondsbyawakeningthepersonenoughtotightentheupperairwaymusclesandopenthewindpipe.Thepersonmaysnortorgasp,thenresumesnoring.Thiscyclemayberepeatedhundredsoftimesanight.Thefrequentawakeningsthatsleepapneapatientsexperienceleavethemcontinuallysleepyandmayleadtopersonalitychangessuchasirritabilityordepression.Sleepapneaalsodeprivesthepersonofoxygen,whichcanleadtomorningheadaches,alossofinterestinsex,oradeclineinmentalfunctioning.Italsoislinkedtohighbloodpressure,irregularheartbeats,andanincreased
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riskofheartattacksandstroke.Patientswithsevere,untreatedsleepapneaaretwotothreetimesmorelikelytohaveautomobileaccidentsthanthegeneralpopulation.Insomehighriskindividuals,sleepapneamayevenleadtosuddendeathfromrespiratoryarrestduringsleep.
Anestimated18millionAmericanshavesleepapnea.However,fewofthemhavehadtheproblemdiagnosed.Patientswiththetypicalfeaturesofsleepapnea,suchasloudsnoring,obesity,andexcessivedaytimesleepiness,shouldbereferredtoaspecializedsleepcenterthatcanperformatestcalledpolysomnography.Thistestrecordsthepatient'sbrainwaves,heartbeat,andbreathingduringanentirenight.Ifsleepapneaisdiagnosed,severaltreatmentsareavailable.Mildsleepapneafrequentlycanbeovercomethroughweightlossorbypreventingthepersonfromsleepingonhisorherback.Otherpeoplemayneedspecialdevicesorsurgerytocorrecttheobstruction.Peoplewithsleepapneashouldnevertakesedativesorsleepingpills,whichcanpreventthemfromawakeningenoughtobreathe.
RestlessLegsSyndrome
Restlesslegssyndrome(RLS),afamilialdisordercausingunpleasantcrawling,prickling,ortinglingsensationsinthelegsandfeetandanurgetomovethemforrelief,isemergingasoneofthemostcommonsleepdisorders,especiallyamongolderpeople.Thisdisorder,whichaffectsasmanyas12millionAmericans,leadstoconstantlegmovementduringthedayandinsomniaatnight.SevereRLSismostcommoninelderlypeople,thoughsymptomsmaydevelopatanyage.Insomecases,itmaybelinkedtootherconditionssuchasanemia,pregnancy,ordiabetes.
ManyRLSpatientsalsohaveadisorderknownasperiodiclimbmovementdisorderorPLMD,whichcausesrepetitivejerkingmovementsofthelimbs,especiallythelegs.Thesemovementsoccurevery20to40secondsandcauserepeatedawakeningandseverelyfragmentedsleep.Inonestudy,RLSandPLMDaccountedforathirdoftheinsomniaseeninpatientsolderthanage60.
RLSandPLMDoftencanberelievedbydrugsthataffecttheneurotransmitterdopamine,suggestingthatdopamineabnormalitiesunderliethesedisorders'symptoms.Learninghowthesedisordersoccurmayleadtobettertherapiesinthefuture.
Narcolepsy
Narcolepsyaffectsanestimated250,000Americans.Peoplewithnarcolepsyhavefrequent"sleepattacks"atvarioustimesoftheday,eveniftheyhavehadanormalamountofnighttimesleep.Theseattackslastfromseveralsecondstomorethan30minutes.Peoplewithnarcolepsyalsomayexperiencecataplexy(lossofmusclecontrolduringemotionalsituations),hallucinations,temporaryparalysiswhentheyawaken,anddisruptednighttimesleep.ThesesymptomsseemtobefeaturesofREMsleepthatappearduringwaking,whichsuggeststhatnarcolepsyisadisorderofsleepregulation.Thesymptomsofnarcolepsytypicallyappearduringadolescence,thoughitoftentakesyearstoobtainacorrectdiagnosis.Thedisorder(oratleastapredispositiontoit)isusuallyhereditary,butitoccasionallyislinkedtobraindamagefromaheadinjuryorneurologicaldisease.
Oncenarcolepsyisdiagnosed,stimulants,antidepressants,orotherdrugscanhelp
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controlthesymptomsandpreventtheembarrassinganddangerouseffectsoffallingasleepatimpropertimes.Napsatcertaintimesofthedayalsomayreducetheexcessivedaytimesleepiness.
In1999,aresearchteamworkingwithcaninemodelsidentifiedagenethatcausesnarcolepsyabreakthroughthatbringsacureforthisdisablingconditionwithinreach.Thegene,hypocretinreceptor2,codesforaproteinthatallowsbraincellstoreceiveinstructionsfromothercells.Thedefectiveversionsofthegeneencodeproteinsthatcannotrecognizethesemessages,perhapscuttingthecellsofffrommessagesthatpromotewakefulness.Theresearchersknowthatthesamegeneexistsinhumans,andtheyarecurrentlysearchingfordefectiveversionsinpeoplewithnarcolepsy.
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TheFuture
Sleepresearchisexpandingandattractingmoreandmoreattentionfromscientists.Researchersnowknowthatsleepisanactiveanddynamicstatethatgreatlyinfluencesourwakinghours,andtheyrealizethatwemustunderstandsleeptofullyunderstandthebrain.Innovativetechniques,suchasbrainimaging,cannowhelpresearchersunderstandhowdifferentbrainregionsfunctionduringsleepandhowdifferentactivitiesanddisordersaffectsleep.Understandingthefactorsthataffectsleepinhealthanddiseasealsomayleadtorevolutionarynewtherapiesforsleepdisordersandtowaysofovercomingjetlagandtheproblemsassociatedwithshiftwork.Wecanexpecttheseandmanyotherbenefitsfromresearchthatwillallowustotrulyunderstandsleep'simpactonourlives.
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TipsforaGoodNight'sSleep:
Adaptedfrom"WhenYouCan'tSleep:TheABCsofZZZs,"bytheNationalSleepFoundation.
Setaschedule:
Gotobedatasettimeeachnightandgetupatthesametimeeachmorning.Disruptingthisschedulemayleadtoinsomnia."Sleepingin"onweekendsalsomakesithardertowakeupearlyonMondaymorningbecauseitresetsyoursleepcyclesforalaterawakening.
Exercise:
Trytoexercise20to30minutesaday.Dailyexerciseoftenhelpspeoplesleep,althoughaworkoutsoonbeforebedtimemayinterferewithsleep.Formaximumbenefit,trytogetyourexerciseabout5to6hoursbeforegoingtobed.
Avoidcaffeine,nicotine,andalcohol:
Avoiddrinksthatcontaincaffeine,whichactsasastimulantandkeepspeopleawake.Sourcesofcaffeineincludecoffee,chocolate,softdrinks,nonherbalteas,dietdrugs,andsomepainrelievers.Smokerstendtosleepverylightlyandoftenwakeupintheearlymorningduetonicotinewithdrawal.AlcoholrobspeopleofdeepsleepandREMsleepandkeepstheminthelighterstagesofsleep.
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Relaxbeforebed:
Awarmbath,reading,oranotherrelaxingroutinecanmakeiteasiertofallsleep.Youcantrainyourselftoassociatecertainrestfulactivitieswithsleepandmakethempartofyourbedtimeritual.
Sleepuntilsunlight:
Ifpossible,wakeupwiththesun,oruseverybrightlightsinthemorning.Sunlighthelpsthebody'sinternalbiologicalclockresetitselfeachday.Sleepexpertsrecommendexposuretoanhourofmorningsunlightforpeoplehavingproblemsfallingasleep.
Don'tlieinbedawake:
Ifyoucan'tgettosleep,don'tjustlieinbed.Dosomethingelse,likereading,watchingtelevision,orlisteningtomusic,untilyoufeeltired.Theanxietyofbeingunabletofallasleepcanactuallycontributetoinsomnia.
Controlyourroomtemperature:
Maintainacomfortabletemperatureinthebedroom.Extremetemperaturesmaydisruptsleeporpreventyoufromfallingasleep.
Seeadoctorifyoursleepingproblemcontinues:
Ifyouhavetroublefallingasleepnightafternight,orifyoualwaysfeeltiredthenextday,thenyoumayhaveasleepdisorderandshouldseeaphysician.Yourprimarycarephysicianmaybeabletohelpyouifnot,youcanprobablyfindasleepspecialistatamajorhospitalnearyou.Mostsleepdisorderscanbetreatedeffectively,soyoucanfinallygetthatgoodnight'ssleepyouneed.
ForinformationonotherneurologicaldisordersorresearchprogramsfundedbytheNationalInstituteofNeurologicalDisordersandStroke,contacttheInstitute'sBrainResourcesandInformationNetwork(BRAIN)at:
BRAINP.O.Box5801Bethesda,MD20824(800)3529424www.ninds.nih.gov
Preparedby:OfficeofCommunicationsandPublicLiaisonNationalInstituteofNeurologicalDisordersandStrokeNationalInstitutesofHealthBethesda,MD20892
NINDShealthrelatedmaterialisprovidedforinformationpurposesonlyanddoesnotnecessarilyrepresentendorsementbyoranofficialpositionoftheNationalInstituteofNeurologicalDisordersandStrokeoranyotherFederalagency.Adviceonthetreatmentorcareofanindividualpatientshouldbeobtainedthroughconsultationwithaphysicianwhohasexaminedthatpatientorisfamiliarwiththatpatient'smedicalhistory.
http://www.ninds.nih.gov/
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24/01/2015 BrainBasics:UnderstandingSleep:NationalInstituteofNeurologicalDisordersandStroke(NINDS)
http://www.ninds.nih.gov/disorders/brain_basics/understanding_sleep.htm 11/11
AllNINDSpreparedinformationisinthepublicdomainandmaybefreelycopied.CredittotheNINDSortheNIHisappreciated.
NIHPublicationNo.063440c
LastupdatedJuly25,2014
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