bone mineral density measurements and risk factor assessment for osteoporosis in saudi females...
DESCRIPTION
Introduction The bones in our skeleton are made of a thick outer shell and a strong inner mesh filled with collagen (protein), calcium salts and other minerals. The inside looks like honeycomb, with blood vessels and bone marrow in the spaces between bone.TRANSCRIPT
Bone Mineral Density Measurements and Risk Factor Assessment for Osteoporosis in
Saudi FemalesPresenter: Jamilah Al-Saedan, Bsc. Pharm
Advisor: Dr. Hisham Abou Auda, PhDCo-Advisor: Maha M Al-Rasheed, Msc. Pharm
Introduction
• Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture.
• Osteoporotic bone changes are initially silent and can progress undetected until a low trauma fraction occurs.
Introduction
• The bones in our skeleton are made of a thick outer shell and a strong inner mesh filled with collagen (protein), calcium salts and other minerals.
• •The inside looks like honeycomb, with blood vessels and bone marrow in the spaces between bone.
Introduction
• Osteoporosis results from an unhealthy imbalance between two normal activities of bone: bone resorption and bone formation.
• •These activities rely on two major types of cells: osteoblasts for bone formation and osteoclasts for bone resorption.
• •These combined processes are referred to as bone remodeling or bone turnover.
Introduction
• Under normal circumstances, bone remodeling should not lead to a net loss of bone.
• Conditions that increase bone resorption or decrease bone formation can cause uncoupling of the remodeling process and lead to bone loss.
Research Question
• Are Bone Mineral Density measurements associated with local cultural risk factors for osteoporosis in healthy Saudi females?
Logistical Procedures
Centers
KSU Malaz PSC Al-Manahil
•Study Design is cross sectional, prospective.
•Participants included 160 healthy Saudi female volunteers from three centers.
Instruments
• 1)Quantitative Ultrasound Device (QUS): SAHARA ultrasound bone densitometer (Hologic, Waltham, USA).
• 2) A scale to measure the weight and height of the entrants.
• 3) Data collection sheet, via a structured interview as a checklist for obtaining the pertinent information.
SAHARA QUS
Exercise Status
Group 1n (%)
Group 2n (%)
Sedentary29(28.7)15(25.4)
Mildly Active
38(37.6)26(44.1)
Moderately Active
25(24.8)10(16)
Very Active
9(8.9)8(13.6)
Total101(100)59(100)
Characteristics of Participants
Participant CharacteristicsExposure to sun (mins/day)
Group 1 (n)
Group 1 (%)
Group 2 (n)
Group 2 (%)
< 159796%5389.8%
15-3033%58.5%
> 3011%11.7%
Total101100%59100%
Participant CharacteristicsReproductiveHistory
Group 1 (n)
Group 1 (%)
Group 2 (n)
Group 2 (%)
Amenorrhea>3month87.9%23.4%
Irregular Menstrual Periods
2726.7%813.6%
Menopause0058.5%
Late menarche (onset>13 yr)
2625.8%2033.9%
Hx of oral contraceptives
98.9%1220.3%
Family Hx of osteoporosis
1716.8%813.6%
Participant CharacteristicsBMD and T-score
Group 1 (Mean)
Group 1 (SD)
Group 2 (Mean)
Group 2 (SD)
BMD0.5690.1230.540.1069
T-Score-0.0771.1-0.350.961
Participant Characteristics
T-ScoreGroup 1 (n)
Group 1 (%)
Group 2 (n)
Group 2 (%)
Normal>17978.2%4169.5%
Osteopenia (-1 to -2.4)
1918.8%1728.8%
Osteoporosis ( >2.5)
11%11.7%
Total101100%59100%