*BLOOD

TRANSFUSION

- Dr.Chintan(9441375293)

**Blood loss – accidents, surgical operations

*Severe anemia

(Pregnancy & emergency surgery

– quick restoration of Hb)

*Exchange transfusion

*Blood diseases – Aplastic anemia, agranulocytosis, leukemias, hemophilia, purpura, clotting & bleeding disorders

*Acute CO poisoning

*Autologous (Elective surgery) - Advantageous

**Donor selection

*Cross matching

*Major – Donor cell with recipient plasma

*Minor – Recipient cells with donor plasma

*Universal donor (O –ve)

*Universal recipient (AB +ve)

*

**Chills, rigors, fever, skin rash, itching, urticaria

*Anaphylactic shock

*Circulatory overload

* Iron overload – hemosiderosis

*Transmission of diseases, alloimmunization

* Infection

*Thrombophlebitis

*Air embolism

*Hyperkalemia

*Hypocalcaemia

*Hypothermia → cardiac arrest → sudden death

**Hemolysis – hemoglobinemia & hemoglobinuria (red urine), heart rate ↑, BP ↓, dyspnea, bronchospasm, nausea, vomiting,, pulmonary edema, CCF…………. Jaundice

*Chest pain, back pain

*Renal stone

*Renal shutdown – anuria

*Renal vasoconstriction, circulatory shock, kidney tubules blockage

*Uremia, Coma, death

*TRALI, FNHTR, DHTR, GVHD

**1 unit of blood (300 ml) – every 3 months

*ACD mixture (21 days)

*Cold storage

- RBC swell (loss of K, ↑ in Na, water)

- 80 % - 24 hrs. – Destroyed at 1% / day

- WBCs, Platelets – absent after 24 hrs.

* Blood components – PCV, FFP, Platelets

*THANQ……