Blood, Sweat, & Tears IIMay 17 & 18, 2016

Dr. Melissa Grupen-ShemanskyCTO SEMI / FlexTechNano-Bio Manufacturing Consortium

Agenda

2

Acknowledgements Schedule at a glance SEMI FlexTech NBMC : Who are

we? NBMC projects Concluding remarks

Acknowledgements

Thank you to our hosts

Thank you to our Governing Council members

17-May

Time Name Talk Title / Focus

8:30

9:00 Dr. Nina Joshi CEO, UESDr. Melissa Grupen-Shemansky CTO, NBMC

Welcome - Day 1

9:30 Charles L. Geraci, Jr., Ph.D., CIH, National Institute for Occupational Safety and Health

The NIOSH Nanotechnology Research Program: The need for Advanced Sensors for Worker Exposure Evaluation and Protection

10:00 Jason Marsh, NextFlex FHE Manufacturing

10:3010:45 Dr. Douglas Casa, University of Connecticut, Korey Stringer Institute Thriving During Physical Activity in the Heat- How Can Technology Help?

11:15 Dr. William Casebeer, Lockheed Martin Advanced Technology Labs (form. AF & DARPA)

Sensor Interpretation: Understanding Blood, Sweat, Tears and Human Performance

11:45 Gaurav N. Pradhan, Ph.D, Mayo Clinic, AZ Application of Eye Tracking and Galvanic Vestibular Inputs for Tracking and Enhancing Human Performance

12:151:15 Dr. Pete Demitry, Form. AFRL - Surgeon General Office Applications for Bio Markers

1:45 Dr. Christian Whitchurch, Defense Threat Reduction Agency Wearable Host-Based Threat Exposure Monitoring

2:15 Jeffery A SteevenJeffrey A Steevens, Ph.D., US Army Engineer Research & Development Centers, Ph.D.

A Risk-Based Framework to Guide the Safe and Rapid Development of Army Nanotechnologies

2:453:00 Dr. Andrew Steckl, University of Cincinnati Paper-Based Microfluidics for Diagnostic Applications3:30 PANEL DISCUSSION Moderated by: Melanie Tomczak, UES & Jeff Stuart, Lockheed Martin

4:20 Dr. Melissa Grupen-Shemansky closing remarks for day 1

4:30

5:30 Networking Dinner Lily's Bistro

18-May

8:30

9:00 Dr. Melissa Grupen-Shemansky, CTO, NBMC Welcome - day 2

9:10Christopher M. Hartshorn, Ph.D. Office of Cancer Nanotechnology Research (OCNR) Center for Strategic Scientific Initiatives (CSSI) National Cancer Institute (NCI) National Institutes of Health (NIH)

Wearable Technologies: Their Future in Patient / Clinician Decision Making

9:40 Dr. Esther Sternberg, MD, Arizona Center for Integrative Medicine Measuring the Impact of the Built Environment on Health and Wellbeing An Overview10:1010:25 Mounir Zok, Ph.D., United States Olympic Committee #REF!10:55 Jorge L. Chvez, Ph.D., 711 HPW/RHXBC STRONG Lab. and Forensic Analysis

11:25 PANEL DISCUSSION Moderated by: Melanie Tomczak, UES & Jeff Stuart, Lockheed Martin

11:50 Dr. Melissa Grupen-Shemansky, CTO, NBMC closing remarks

12:00

12:00 Tour Air Force Research Laboratory

Break

Adjourn

Continental Breakfast

Break

Lunch

Break

Adjourn

Continental Breakfast

Schedule at a Glance

Agenda

17-May

TimeNameTitleCompanyLeadEmailTalk Title / FocusStatusNOTESTelephoneInvite SentInstructionsAbstractHeadshotBioLogoSpeaker AgreementRegistered?PresentationPresentation Notes

8:30Continental Breakfast

9:00Dr. Nina Joshi CEO, UESDr. Melissa Grupen-Shemansky CTO, NBMCNBMCmegshemansky@semi.orgWelcome - Day 1YES

9:30Charles L. Geraci, Jr., Ph.D., CIH, National Institute for Occupational Safety and HealthAssociate Director for NanotechnologyNational Institute for Occupational Safety and HealthDoyle Edwardscgeraci@cdc.govThe NIOSH Nanotechnology Research Program: The need for Advanced Sensors for Worker Exposure Evaluation and ProtectionCONFIRMEDSent bio, hs, and summary513-533-8339YESThe National Institute for Occupational Safety and Health (NIOSH) is the lead agency within the US National Nanotechnology Initiative (NNI) charged with occupational safety and health research as part of the US goal for responsible development of nanotechnology. The NIOSH program is a broad research effort intended to explore the possible worker implications and applications of nanotechnology. Evaluating potential health impacts of worker exposure to nanomaterials relies heavily on measurements that could be improved dramatically by advances in sensor technology: environmental and biological. Worker safety would also benefit from more advanced sensor systems that could provide information on the performance of protective clothing and equipment. This presentation will provide an overview of the NIOSH program and the role sensor technology will play.YESYESYESYES

10:00Jason Marsh, NextFlex CMSGTAir Force Materiel CommandLaura ReaFHE ManufacturingCONFIRMEDExpanding the scope of USAF applications beyond the cockpit, CMSGT Nixon, and other representatives from AFMC, will discuss environmental and operational situations on the flight line, within the security forces, and in the realm of the nuclear mission, which could benefit from advanced human performance monitors.

10:30Break

10:45Dr. Douglas Casa, University of Connecticut, Korey Stringer InstituteUniversity of Connecticut, Korey Stringer InstituteAzar douglas.casa@uconn.eduThriving During Physical Activity in the Heat- How Can Technology Help?CONFIRMEDSent bio, headshot, talk title & abstractYESThe ability of a soldier, athlete, or laborer to thrive during intense exercise in the heat is directly related to their ability maximize exercise heat tolerance. The process of enhancing exercise heat tolerance brings together a myriad of factors such as fitness, hydration, heat acclimatization, core temperature tracking, sleep, body cooling, and many other issues. The advancements in portable/wearable/field expedient tracking/monitoring devices have allowed for an enhanced preparation and performance when intense exercise needs to be conducted in hot conditions. The challenge ahead is real time assessment of hydration and body temperature in a convenient fashion for the equipment laden individual.YESYESYES

11:15Dr. William Casebeer, Lockheed Martin Advanced Technology Labs (form. AF & DARPA)Lockheed Martin Advanced Technology Labs (form. AF & DARPA)Jeff Stuartwilliam.d.casebeer@lmco.comSensor Interpretation: Understanding Blood, Sweat, Tears and Human PerformanceCONFIRMEDSent bio, hs, title & abstractYESAssessing the meaning of data collected by physiologic sensors is difficult. Here, I discuss the need for coevolution between sensor development and novel techniques for interpreting data in near-real time so that it can be used for performance assessment and improvement in human-machine teams.YESYESYESYES

11:45Gaurav N. Pradhan, Ph.D, Mayo Clinic, AZAssociate Professor of MedicineMayo ClinicMelissastepanek.jan@mayo.edupradhan.gaurav@mayo.eduApplication of Eye Tracking and Galvanic Vestibular Inputs for Tracking and Enhancing Human PerformanceCONFIRMED - wants a spot earlier in your program (Moved from 2:20)Sent title, abstract, headshots & biosYESThe work environment for operators in the Aerospace and Defense Arena have become increasingly more focused on sophisticated and highly dynamic visual inputs. This very fact offers the opportunity to assess cognitive status of the operator by virtue of noncontact monitoring of surrogate measures of performance such as eye tracking parameters (measured via infrared light). Eye tracking allows for the derivation of performance patterns, that can be identified and then can serve as a warning to the operator should cognitive compromise/decline due to a variety of factors such as hypoxia, fatigue, concussion, drug effect or other factors occur.Our laboratory has studied the effects of hypoxia and concussions on eye tracking performance building upon a modification of the King Devick test.Another important consequence of highly dynamic visual inputs in the work environment, especially in simulation and remote monitoring, is the inherent conflict between the rich visual stimulating input and a lacking corresponding inner ear input resulting in simulator sickness or virtual reality sickness.The application of galvanic vestibular stimulation (GVS) can be a valuable physiologic resynchronization with what the human body expects and hence mitigate the potential motion sickness and performance degradation.YES

12:15Lunch

1:15Dr. Pete Demitry, Form. AFRL - Surgeon General OfficeForm. AFRL - Surgeon General OfficeLaura Reademitry@me.comApplications for Bio MarkersCONFIRMEDSent bio, headshot, talk title, abstractYESThis presentation will address end user requirements and attributes for discussed biomarker solutions from the speaker's perspective. The objective is to provide industry with understanding and rationale for the various configurations based on final field applications so that they are confident in extrapolating and being able to align with operational requirements as researched by the speaker.YES

1:45Dr. Christian Whitchurch, Defense Threat Reduction AgencyERROR:#REF!Elizabeth to reach out for confirmation(4-20-16) / Laura Rea reach out Christian.j.whitchurch.civ@mail.milWearable Host-Based Threat Exposure MonitoringCONFIRMED Sent title, abstract, LOAYESTwo technologies are rapidly converging: wearable technologies for health/physiology monitoring, and biomarker discovery for exposure/infection. Progress here predicts development of a wear-and-forget, host-based sensor suite that continually monitors the warfighter for signs of infection or exposure to a range of threats that degrade health and performance. The DTRA initiative aims to develop a suite of wear-and-forget sensors capable of recognizing and tracking physiological signs of infection, injury or insult prior to the onset of mission disruptive symptoms. This is not intended to be a specific diagnostic, but rather a cue for testing (data rich check engine light) aiding in health tracking of individuals, units, and populations. This S&T approach will exploit biotech, system autonomy, miniaturization, big data, and advanced manufacturing industries. Such a capability would facilitate pre-symptomatic detection of threats to force readiness, thus enabling rapid countermeasure deployment and associated reduction in rate of spread of infectious disease, leading to accelerated defeat of disease outbreaks, decreased health costs, and the preservation of force strength. YESYES

2:15Jeffery A SteevenJeffrey A Steevens, Ph.D., US Army Engineer Research & Development Centers, Ph.D.Senior Scientist (ST)US Army Engineer Research and Development Center - Environmental LaboratoryDoyle EdwardsJeffery.A.Steevens@usace.army.milA Risk-Based Framework to Guide the Safe and Rapid Development of Army NanotechnologiesCONFIRMEDSent bio, headshot, title & abstract601-634-4199YESA risk-based framework was developed by USACE to classify nanotechnologies and guide the collection of data to support an assessment of environmental health and safety of technologies that employ engineered nanoparticles. The Nano Guide for Risk Informed Deployment (Nano GRID) is a 5 tiered process to guide the collection of exposure and effects data balancing the cost of the data collection with the value of the information; ultimately supporting regulatory and business decision-making. The goal of this tiered screening guidance is to guide the generation of relevant, nano-specific data, as well as provide information with respect to data collection methods, and when sufficient data have been collected. In addition to the decision framework, ERDC is developing a series of test protocols to support the data requirements identified in the framework. The utility of the framework and protocols will be described for several Army technologies that are in development.YESYESYES

2:45Break

3:00Dr. Andrew Steckl, University of CincinnatiDistinguished Research Professor, Gieringer Professor and Ohio Eminent ScholarUniversity of CincinnatiMelaniea.steckl@uc.edu; steckla@ucmail.uc.eduPaper-Based Microfluidics for Diagnostic ApplicationsCONFIRMED513-556-4777 YESTo Be ProvidedYES

3:30PANEL DISCUSSIONModerated by: Melanie Tomczak, UES & Jeff Stuart, Lockheed MartinCONFIRMED

4:20Dr. Melissa Grupen-ShemanskyNBMCmegshemansky@semi.orgclosing remarks for day 1YES

4:30Adjourn

5:30Networking DinnerLily's Bistro

18-May

8:30Continental Breakfast

9:00Dr. Melissa Grupen-Shemansky, CTO, NBMCNBMCmegshemansky@semi.orgWelcome - day 2YES

9:10Christopher M. Hartshorn, Ph.D. Office of Cancer Nanotechnology Research (OCNR) Center for Strategic Scientific Initiatives (CSSI) National Cancer Institute (NCI) National Institutes of Health (NIH)Program DirectorOffice of Cancer Nanotechnology Research (OCNR) Center for Strategic Scientific Initiatives (CSSI) National Cancer Institute (NCI) National Institutes of Health (NIH)Laura Rea christopher.hartshorn@nih.govWearable Technologies: Their Future in Patient / Clinician Decision MakingCONFIRMEDReceived abstract, title, bio & headshot301-435-3941 (office)202-322-3081 (mobile)YESWearable technologies for the consumer market have recently seen widespread adoption with a massive increase in sales of more than 180% in 2015. These wearable devices are designed to measure multiple human performance-based metrics via built-in and/or external sensors, continuously. As such, they offer much as a personal measure to relative health. While these consumer devices mature and the next generation of devices make their way to market, vis--vis lower-complexity flexible designs, perspiration sensors, and much more, will they offer more than just a relative health assessment by the user? Will they be able to convey objective information en masse to measure the subtler aspects of health versus disease in large epidemiology cohorts, give clinicians the ability to measure patient fatigue during treatment, or more? This talk will focus on several large scale initiatives at the National Institutes of Health and attempt to chart the path forward relative to these questions.YESYESYES

9:40Dr. Esther Sternberg, MD, Arizona Center for Integrative MedicineResearch Director, Arizona Center for Integrative MedicineDirector, UA Institute on Place and WellbeingProfessor of MedicineArizona Center for Integrative MedicineLaura Reaesternberg@email.arizona.eduMeasuring the Impact of the Built Environment on Health and Wellbeing An OverviewCONFIRMED - May 18 onlyReceived abstract, title, bio & hs(520) 626-9947YESDr. Sternberg will review how the built environment affects health, and will introduce cutting edge wearable, real-time technologies measuring the health and wellbeing impacts of buildings, going beyond removing negative factors towards adding positive factors. She will review previous research with the US General Services Administration in this domain, and will discuss how the University of Arizona sweat biomarker program fits with this approach. This knowledge will help design professionals create healthy environments in all building types, and policymakers include health outcomes in green design standards.YESYESYES

10:10Break

10:25Mounir Zok, Ph.D., United States Olympic CommitteeSenior Sports TechnologistUnited States Olympic CommitteeERROR:#REF!MOUNIR.ZOK@USOC.ORGERROR:#REF!CONFIRMED719-866-2005; 719-439-6974YESTo Be ProvidedYES

10:55Jorge L. Chvez, Ph.D., 711 HPW/RHXBCResearch Chemist711 HPW/RHXBCLaura Reajorge.chavez_benavides.2@us.af.milSTRONG Lab. and Forensic AnalysisCONFIRMED937-938-2575YESTo Be ProvidedYES

11:25PANEL DISCUSSIONModerated by: Melanie Tomczak, UES & Jeff Stuart, Lockheed MartinCONFIRMEDYES

11:50Dr. Melissa Grupen-Shemansky, CTO, NBMCNBMCmegshemansky@semi.orgclosing remarks

12:00Adjourn

12:00TourAir Force Research Laboratory

mailto:megshemansky@semi.orgmailto:cgeraci@cdc.govmailto:Christian.j.whitchurch.civ@mail.milmailto:Jeffery.A.Steevens@usace.army.milmailto:megshemansky@semi.orgmailto:megshemansky@semi.orgmailto:jorge.chavez_benavides.2@us.af.milmailto:megshemansky@semi.org

Sheet1

WHO ARE WE?

Enabling the FHE Industry Ecosystem from Market Research to Manufacturing

6

Promoting the development of the global electronics supply

chain through Market research Business, collaboration, and

& education events Standards Consortium

R&D ProgramsFHE

R&D Programs

1970s 1993 2013 2015

For the advancement of US manufacturing in

flexible hybrid electronicsClosing technology gaps in flexible hybrid electronics

NBMC Projects Underway

# Development Partner/Project

5 Visca - Helmet Integrated Neurospinal-Hydration Sensor

6 Molex - Biomarker Monitoring Device Manufacturing

7 Binghamton University - Biometric Human Performance Monitor

8 Lockheed Martin - Computational Approaches to Enhancing Performance in FHE Sensor Architectures

9 American Semiconductor Enabling Manufacturing of Flexible Hybrid Circuits

10 Univ. of Massachusetts @ Amherst - Wearable Paper-based Microfluidic Biomarker Sensor Patch

11 UES Selective Reversible Surface Functionalization of RF Sensors for Non-Invasive Hydration Monitoring

12 GE - Wearable Device for Dynamic Assessment of Hydration Status

Representing more than $7.5M in public and private development investment

Wearable Device for Dynamic Assessment of Hydration Status GE Global Research

OBJECTIVES: Design and fabricate an integrated flexible and fully wearable hydration monitoring system composed of electrical impedance and sweat sensors for continuous and non-invasive measurements of fluid and electrolyte content.

BENEFITS: Military safety, physical, and cognitive performance during training & combat.

Civilian medical patient monitoring & athletic performance enhancement

Selective electrodes: absorb/desorb of Na+ and K+

Define clinically relevant hydration index Sensitivity to 0.5% change in body fluid Microfluidics

6 hour continuous operation initially Wireless communication R2R printing demonstration

Pr

Project Team

Technology Elements

Enabling Manufacturing of Flexible Hybrid Systems American Semiconductor

Project Team

12 Month, $1M Project for Maturing the MRL and Enabling Manufacturing of Flexible Hybrid Electronics

OBJECTIVE: Leverage the FleXform-ADC kit to improve printed electronics and hybrid assembly to MRL6.

BENEFITS: Accelerate FHE on-shore manufacturing capability reducing cost, increasing yield, and establishing reliability

3081 Zanker Road, San Jose, CA 95134Office: 408-943-7030

FleX-IC wafer handling: mount, demount, test, pick & place FleX-IC wafer singulation Hybrid electrical interconnect and sensor integration Torsion and bend tests

Technology Elements

Sensor for Monitoring Human Biometric Parameters Binghamton University

Project Team

Copper trace to printed circuit interconnection and reliability Printed thermistor and electrode optimization Wireless data transmission Improved signal conditioning to minimize noise and motion artifacts Reduced power

Technology Elements

OBJECTIVE: Develop wearable biometric monitor for ECG, skin temperature, heart rate, heart rate variations and wireless transmission of complete ECG waveform

BENEFITS: Accurate biometric monitoring for personnel performing stressful or repetitive tasks for military, health and wellness, and athletic performance applications.

Biomarker Monitoring Device Manufacturing - Molex

12 Month, $1.4MM Program to increase the MRL ofFlexible Lactate Biomarker Carbon-NanotubeDevice Manufacturing Processes and IntegratedBiomarker Sensor Systems.

Project Team

OBJECTIVE: Develop a lactate biomarker sensing platform and fabricate prototypebiosensor monitoring devices to detect lactate at concentrations relevant to humanphysiological monitoring.

BENEFITS: Noninvasive continuous monitoring of lactate levels in sweat of humansunder intense physical exertion or hypoxia symptomatic of some health conditions.

Functionalized single-walled carbon nanotube manufacturing Lactic acid sensor multi scale print fabrication at MRL5 Sensor system integration Hybrid component, FleX-ADC, & FleX-MCU integration

Technology Elements

Wearable Microfluidic Biomarker Sensor PatchStatus UMass

Project Team

OBJECTIVE: Develop wearable impedance RF sweat sensor and microfluidics for non-invasive, continuous and simultaneous monitoring of multiple biomarkers (Orexin A, IL-6,NP-Y) .

BENEFITS: Military safety, physical, and cognitive performance during training & combat.Civilian medical patient monitoring & care

Multi-variant resonant impedance RF sensor Multi-biomarker functionalized sensor sensitivity and selectivity R2R printing architectures and scalable manufacturing process

Technology Elements

Helmet Integrated Neurospinal- Hydration Sensor Visca, LLC

The goal of this proposed program is todesign and integrate an ultra-thin, flexibleelectronics based, low cost, stretchablesensor system for precision passivemeasurement of both levels of humanhydration and motion for both military andcivilian needs. The proposed approach forhuman performance hydration monitoring,body stress and injury detection supports theemerging field of individualized medicalmonitoring for real time-event. alert andpost-event treatment.

Project to Develop an Integrated Hydration and Motion Assessment Device

Technical ApproachTo meet the program goal, four key objectives have been identifiedto be achieved during the proposed effort. These are:

Objective

Fabrication & Integration of Flexible Electronics Based Sensor System, to include: Fabrication of Arrays for 4 complete

Prototype Sensors Integration of Prototype Sensor into

Flight Helmet Integration of Prototype Sensor into

Soldier/Pilot Helmet

Demonstration of Flexible Sensor System, to include: Limited (non-human subject) Testing Impact Testing Hydration Simulation TestingManufacturing Roadmap Development, to include: Production Process, Gap Analysis and

Readiness Production Scale Plan

Deliverables

Design & Modeling of the Flexible Electronics Based Sensor System, to include: Impedance Hydration Biometric Array Microgryo Accelerometer Array and

Head Placement Location(s) Thin Film Polymer Battery &Flexible

Electronic Conductors Blue Tooth Transmitter & Data

Recording

Anticipated Benefits Accurate determination of hydration andsingle event/cumulative events head/spineinjury is seminal to determiningindividual military readiness and longterm post event healthcare

Computational Approaches to Enhancing Performance in FHE Sensor Architectures Lockheed Martin

Team Lockheed Martin Advanced

Technologies Laboratories (LM ATL, Shashi Adiga and Jeff Stuart)

AFRL/RX (Ruth Pachter)

ObjectivesLM ATL and AFRL/RX will coordinate with the separately funded NBMC effort led by Binghamton University (BU), including I3 Electronics, American Semiconductor, and UC Berkeley. The team will use computational physics based approaches to identify and mitigate design and fabrication challenges, and optimize electrical and mechanical performance in BU Biometric Human Performance Monitor (BHPM) through actionable guidance. As such, iterative modeling and fabrication cycles will accelerate device design.

ApproachChallenge: First generation multi-laminate FHE sensor devices fabricated by BU have experienced problems with electrical and mechanical reliability. Furthermore, optimized power utilization solutions are needed. Four tasks have been formulated through extensive discussions with the BU team and have been designed to address specific challenges:

Mechanical reliability Electrical interface reliability (with AFRL) Optimization of communications system

architecture and design Analysis of alternatives antenna study

Task 2: CFD, FEA, and DFT approaches will be used to address current fabrication issues with heterogeneous electrical interfaces on flexible substrates.

Task 1: Iterative computational, design, and fabrication cycles will close the loop by accelerating device maturity through predictive computational models.

Task 4: EM model of an ATL-designed harmonic radar reflector antenna: alternatives will be explored for both design and fabrication

Deliverables Analyses of mechanical and

electrical performance as a function of materials, design, and fabrication approach.

Detailed computational models for each system investigated

Recommendations for design revisions for both device fabrication and communication system architectures

Comparative antenna performanceBenefits Efficient exploration of the design

parameters space Risk mitigation Demonstration of the importance

of in-the-loop computational modeling to FHE

Long-Term: Predictive physics-based models will advance NBMC & FHE MII goals through design rules, materials & process selection, and ultimately, selection of standards.

Features and Benefits of Being a Member of NBMC

Technical Council Seat Help define technology gaps & ecosystem needs Work closely with Air Force Research Lab

visionaries to create solutions Participate in the proposal review and project

selection R&D project participation / leadership Share strategies and/or results with potential

partners and customers in a collaborative, confidential environment

Member discounts for workshops & conferences

Flexible Hybrid Electronics

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Application space for conformal electronics merging printed technologies with conventional high performance ICs is far reaching

Driving low cost Pushing low power with wireless

connectivity Demanding non-invasive, real-time,

continuous accuracy and precision with an increasing sensory experience

The supply chain is distributed connecting manufacturers and technologies that have not coexisted in the past creating technology gaps and integration opportunities

Flexible

Hybrid

BLOOD, SWEAT, & TEARS IIWithout further delay

The Mission

Advocate for the FHE Industry

Connect & Educate

Champion R&D Funding

Build awareness within stakeholder communities about flexible hybrid electronics (FHE) and the impact of the technology on products and markets.

Work with the community to create advanced systems that leverage FHE strengths of lower weight, lower power, printable and large area electronics.

Develop and sponsor conferences, workshops, webinars and other networking opportunities for our community.

NextFlex NNMI Mission

Advance the FHE ecosystem through partnerships and development funding in gap areas

Create Americas axis of collaboration for FHE technology and provide expertise and tools sets to innovators in that space

Develop processes for FHE manufacturing that can be deployed to industry - hastening the learning curves

Engage in workforce development at the university, trade-school, and industry level to create a talent pool within the US for FHE manufacturing

Ensure that America and NextFlex members have leading technology and access to a global ecosystem for FHE serving both DOD and commercial product development interests

Flexible Hybrid Electronics are.Flexible:

Not rigid: plastic, paper, fabric. Also glass, metal foil, ceramic

20

Hybrid: Combination of printing &

silicon-based die (usually thinned)

Combo of intelligence + printed (see )

Components must stay attached when flexed and stretched

Printed Electronics: Using conventional

printing technique At atmosphere Conductive inks Bigger market, but

less challenging

Advantages of Devices based on FHE

21

Advanced Materials:Functional InksNanomaterialsGrapheneAdhesives EncapsulantsSubstrate MaterialsBio-recognition Elements

Manufacturing Challenges:Integration StrategiesModeling & Simulation ToolsPrototype DevelopmentMoving to Pilot line Roll-to-Roll Web ProcessingPackaging & Pick-PlaceToolsetsPrinters throughput Material HandlingTest & Reliability

Applications/IoT:Human Health Monitoring/WearablesStructural Health Monitoring Consumer GoodsSmart Packaging/Secure PackagingSolar/PV/Energy harvestingPharmaceuticalsSmart Sensor SystemsAnd Many More..

Enable electronics to use less power & be lighter Manufacture more economically and closer to the customer Conform to people and things (get out of the box!) Enable the internet of things intelligence based on automatic collection and

analyzed information Greener in many cases

Our Network Includes the Leaders in FHEWe connect, educate and fund companies, universities and organizations throughout the supply chain.

23

FlexTech, NBMC, NextFlex

Focus FHE demonstrators, equipment, materials, processes, industry-bldg. information

$2, 36hr patch which measures biomarkers, every 20s, and communicates that info

FHE Manufacturing

Started 1993 2013 2015

Lead Michael Ciesinski, President Melissa Grupen-Shemansky, CTO

Malcolm Thompson, Exec. Director

Membership SEMI dues as basePlus $500 FlexTech SIG or $5000 for Ind. Gov. Council & Technical CouncilBased on desired involvement

3 Levels for Corporate $25K/30K/35K$12.5K/15K/18K$5K/6K/7KAcademic $1500Desired Involvement

3 Levels of Corporate$150K/50K/10K 2 Levels for Academic $15K/7.5Based on desired level of involvement

Funding Avg. $3M every other year through Army Research Labs (ARL) Projects 60% industry funded

$1.8M to start from AFRLAdded $5M in 2015Projects 60% industry funded

$75 M over 5 yearsProjects 60% industry funded

Projects 200+, over $300M total value; 5-10 projects/yr

10 Projects over 3 years Just about to contract for first round 8 projects

Project Calls/RFP

Once a year, although good ideas always welcome

Whenever $ are available Oct. 15, April 16, Oct 16, etc.

24

Manufacturing Readiness Level (MRL) Assessment Criteria

Definitional Material Solution Analysis Technology Development & Commercial Merit

Engineering & Manufacturing Development

MRL 1Mfg

feasibility assessed

MRL 2Mfg

conceptsdefined

MRL 3Proof of

mfgconcept

MRL 4Breadboard

and manufacturing processes in a

laboratory environment

MRL 5Breadboard &

component manufacturing in a relevant environment

MRL 6Prototype, system &

subsystem in

production relevant

environment

MRL 7Prototype, system &

subsystem in

operations and

production environment

MRL 8Pilot line capability

demonstrated; Ready to begin low-rate initial

production

MRL 9Low-rate

production demonstrated;

capability in place to begin

full-rate production

FHE Overall funding has recently been focused on development of components

Very focused on Nano-Bio Manufacturing Development (Patch)

FHE Manufacturing

Blood, Sweat, & Tears IIMay 17 & 18, 2016AgendaAcknowledgementsSchedule at a GlanceWho are we?Enabling the FHE Industry Ecosystem from Market Research to ManufacturingNBMC Projects Underway Wearable Device for Dynamic Assessment of Hydration Status GE Global ResearchEnabling Manufacturing of Flexible Hybrid Systems American Semiconductor Sensor for Monitoring Human Biometric Parameters Binghamton UniversityBiomarker Monitoring Device Manufacturing - MolexWearable Microfluidic Biomarker Sensor PatchStatus UMassHelmet Integrated Neurospinal- Hydration Sensor Visca, LLCComputational Approaches to Enhancing Performance in FHE Sensor Architectures Lockheed MartinFeatures and Benefits of Being a Member of NBMCFlexible Hybrid ElectronicsBlood, Sweat, & Tears iiThe MissionNextFlex NNMI MissionFlexible Hybrid Electronics are.Advantages of Devices based on FHEOur Network Includes the Leaders in FHEFlexTech, NBMC, NextFlexSlide Number 24