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Okogtbchogigmy kod Hbkithckrb ao thb Dbvbigpaom ]grid Syfpgsauf

SQOTHBSAS KOD JAGCHBFACKI CHKZKCTBZAPKTAGOGL SGFB OB] KOTALROMKI KMBOTS DBZA\BD LZGFCG^^BZ (AA) SRZLKCTKOT ]ATH O-DGOKZ IAMKODS

^GG@K SKXBOK,OBT-@ZL,Chbfastry

MG\T. CGIIBMB DKRSK, ZK@KSTHKO (AODAK)

:;-:: Sbp.:>>1

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KJSTZKCTThb chbfastry gl cgfpibxbs dbravbd lrgf cgppbr surlkctkots wath O-

dgogr iamkod ao faxbd sgivbots krb afpgrtkot lgr thbgrbtacki kod

kppiabd krbks gl rbsbkrch aociudaom jkctbraki kod luomacadki kokiysas.

Fbtki cgfpibxbs gl thb iamkods cgotkaoaom oatrgmbo kod suiphur dgogr

ktgfs krb eogwo tg pgssbss kotafacrgjaki, kotavarki, kotaluomki kod

kotacgovuiskot kctavatabs. Thb O-dgogr iamkods hkvb jbbo sbrvaom ks

thb jksas gl k vkrabty gl drums lgr gvbr lavb dbckdbs. Thbsb iamkods krbrbcgmoazbd ks phkrfkcgphgrbs hkvb rbcbavbd mrbkt kttbotago ao drum

dascgvbry kod Ibkd gptafazktago. Ao thb cgfpibxktago cgppbr as gob gl

thb hbkvy trkosatago fbtki thkt as ckpkjib gl jbaom tgxac whbo prbsbot

jbygod thb tgibrkocb ibvbi kod thus cgppbr cgfpibxbs kct ksaosbctacadbs kod luomacadbs. Thb pkthgmboac kctavaty as bohkocbd go

cgfpibxaom kod O-C-S iaoekmb prbsbot ao kjgvb cgfpguods fkebs

thbf tg vbrsktaib jagigmacki aotbrbst kod chbfgthbrkpbutac kmbots..

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Thus go thb jksas gl kjgvb kppiacktagos, at jbcgfbs vbry cibkr thkt :-

kfaog jbozgthakzgib kod thbar sujstatutbd dbravktavbs hkvb jbbo lguod

tg jb vbry kctavb kmkaost vkrabty gl jkctbrak, luoma, hbrjs kod aotbrsbct,

sg ao thb prbsbot aovbstamktago sgfb obw kotaluomki kmbots krb dbravbdlrgf cgppbr-pkifatktb kod :-kfaog jbozgthakzgib, thb fgibcuikr

structurb kod mbgfbtry gl thb syothbsazbd cgfpibxbs hkvb jbbo

cgolarfbd jy thbar bibfbotki kokiysas, fgibcuikr wbamht, R.\., A.Z,

OFZ kod BSZ spbctrki studabs. Thb puraty gl thb cgfpguods hks jbbochbcebd jy thao ikybr chrgfktgmrkphy, kii thb cgfpguods krb cgigrbd

kod pgwdbrbd ao okturb. Thb kotaluomki studabs gl thb syothbsazbd

surlkctkot, iamkods kod cgfpibxbs hkvb jbbo tbstbd kmkaost dallbrbot

cgocbotrktago jy kmkr piktb tbchoaqub. Thb bllbct gl sgivbot hks jbbo

bxciudbd jy cgfpibtb bvkpgrktago.

At hks jbbo gjsbrvbd thkt thb kctavaty aocrbksbs wath thb aocrbksb ao

thb cgocbotrktago gl thb sgiutago. Thb cgfpibxbs shgw hamhbr kctavaty,

summbstaom thkt thb cgfpibxbs krb fgrb pgwbrlui kotaluomki kmbots ks

cgfpkrb tg purb surlkctkot kod iamkods.

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Syothbsas gl cgfpibxbs

Spbctrki studabs gl cgfpibxbs

Jagcadki studabs gl cgfpibxbs

CGOTBOTS

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O

S

OH:

Z

Z6GCH3,OG:,Ci,CH3

Sujstatutbd Jbozgthakzgib

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Lgrfktago gl Sujstatutbd

Jbozgthakzgib

Thb rbquarbd jbozgthakzgib wks

syothbsazbd jy THAGCQOGMBOKTAGO gl p-

fbthgxykoaiaob ao thb prbsbocb gl thagcyogmbomks, whach wks mbobrktbd ao satu jy thb rbkctago

gl cuprac chigradb kod kffgoauf thagcyoktb.

Faxturb wks rbliuxbd lgr gob hgur. Kltbr cggiaomsgdauf ckrjgoktb wks faxbd tg obutrkiazb thb

faxturb. Thb sgiad sbpkrktbd gut wks laitbrbd kod

rbcrystkiiasbd wath bthkogi.

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Sujstatutbd

Jbozkthakzgib

Sujstatutbd

Koaiaob

Z

OH:

SCO:

Z

OH: ( SCO ):

Z

O

S

OH:

Z6 Ci,CH3,GCH3,OG:,

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IAMKOD FGABTQ

:-kfaog-

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LGZFKTAGO GL CGF^IBXIAMKOD 0 CG^^BZ SGK^

: ;

FAXAOM

ZBLIRX

Thb cgfpibxbs waii jb prbpkrbd jy faxaom thb fbtki-

surlkctkot kod iamkod ao thb fgikr rktag gl ;0:,dassgivaom aobthkogi kod faxturb as rbliuxbd lgr kjgut ;-: hgurs.

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CGF^IBXS

C^UJTKVT- Cgfpibx gl cgppbr pkifatktb wath

:-kfaog-

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Hamhiamht go Kppiacktago

Thbsb cgostatutb k afpgrtkot kod aotbrbstaom cikss gl drums/dybs ogtgoiy gr samoalackot jut kisg lgr thbar usbluiobss tg rbsast dasbksb aohufko jbaoms.

Cgppbr (AA) surlkctkots hkvb fkoy kppiacktagos ao vkragus labids iaeb

wggd prbsbrvktago, lgkfaom, wbttaom, hbrjacadki, pbstacadki kctavatabs,dbtbrmbocy, bfuisalacktago, pkaots, iujracktago btc.

Cgfpguods hkvaom k wadb rkomb gl phkrfkcgigmacki kod jagigmackikctavatabs, thby hkvb jbbo usbd ks trkoquaiazbrs, kota-aolikffktgry,

sbdktavb, kotavarki, kotafkikrakis btc.

Cgfpibxbs spbcakiiy cgotkaoaom O dgokr iamkod prgducb kobxcbiibot cikss gl dybs lgr lajbrs whach krb stkjib tgwkrds suoiamht,kcadac kod jksac fbdaufs.

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Tkjib-:

Kokiytacki Dktk gl Cgppbr Sgkp, Iamkod kod Cgfpibxbs

Fbtki Cgotbot(%) O- Cgotbot SCgotbot

gkp/ IamkodCgfpibx Gjsbrvbd Ckicuiktbd Gjsbrvbd Ckicuiktbd Gjsbrvbd Ckicuiktbd

C^ - ;;.>= - - - -

(JTK)T - - 8.4= 8.23 ;1.4> ;1.2;

(JTK)C - - ;2.;> ;2.;8 ;=.:8 ;=.34

C^(JTK)T 8.8; 8.8= - 3.8> - 4.34

C^(JTK)C 8. 8.

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AZ spbctrk gl CSUJTKVOK

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AZ spbctrk gl CSUJTKVK

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AZ spbctrk gl CSUJTKVT

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AZ spbctrk gl CSUJTKVT

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AZ spbctrk gl CSUJTKVT

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KOTALROMKI STRDQ

C.kijackos

C.ErusaKtbrokrak kitbroktk

Kspbrmaius oambr

Dase Dallusago TbstRSK,CISA F-44K

Dbpkrtfbot gl Facrgjagigmy, @.I.O. Fbdacki Cgiibmb, K`fbr

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Daspbosaom thb Stkodkrd kod Tbstaom Dase goaogcuiktbd Kmkr ^iktbs

Aogcuiuf Suspbosago go kmkr piktbs

^rbprktago gl Fubiibr Haotgo kmkr Fbdauf

Fubiibr-Haot go kmkr ^iktbs

^iktbs wbrb stgrbd ao aocujktbr

Aohajatgry Pgob dakfbtbr wks fbksurbd

Dase Dallusago Tbst rgcbdurb

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;>>)(% XC

TCAohajatao

T 6 Dakfbtbr gl luomki cgigoy ao rbst piktb

kltbr 48 hgurs

C6 Dakfbtbr gl luomki cgigoy ao cgotrgi piktbkltbr 48 hgurs

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Kotafacrgjaki kctavaty gl tbstaom cgfpguods kmkaost

C. kijackos

>

2

;>

;2

:>

CSUJTK

VK

CSUJT

KVOK

CSUJTK

VT

CSUJTK

VC

UJTK

VK

UJTKVOK

UJTK

VT

UJTK

VC

TBSTAOM CGF^IBX

AOHAJATAG

O

PGOB(f

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Kotafacrgjaki kctavaty gl tbstaom cgfpguods

kmkaost C. eruska

>

:

4

;:

;4

;1, 11.

3.@kiki F.K.L, Hgsskao. F.J, \kodbr Hbif. D, Skodbrs Igbhr. @, Kctas, I.K kod

Crgsk. @.H @.Kf. Chbf. Sgc., ;181, ;;;, :1:,

.4.Fastry. E, kod Dbska. E.Z, Aodako @. Chbf. Sbct. J, :>>4, 44, ;28.

>:).

=.Okfkza. H, Farzkba. Q.Z, kod Kzkfkt. H, @. Hbtbrgcyciac Chbf. :>>;,38, ;>2;.

8.Saomh D.\, Fashrk. K.Z kod Fashrk. Z.F, Aod. @. Hbtbrgcyciac Chbf, :>>4, ;4, 43.

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1.Fktuurk. Z. Oappgo Ekmgeu Ekasha 8: (;1>>

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;1.Kdkfs. Z 0 Grmkoac Zbkctagos @gho ]aiby kod Sgos, Obw Qgre 3 (;121) :4>.

:>.Hgrslkii. M 0 Jgt. Zbv. ;; (;142) 32=.

:;.(k) Jbiikfy. I. @, Aolrkrbd Spbctrk gl cgfpibx Fgibcuibs. @gho ]aiby&

Sgos, Aoc, Obw Qgre, ^. 3 (;1>

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Thkoes lgr ygur eaod ttbotago....

Supbrvasgr Dr. Obhk Fkthur

Cg-aovbstamktgr Afrko Khfkd