Relationship between measured average glucose by continuous glucosemonitor and HbA 1c measured by three different routine laboratory methodsTze Ping Loh, Sunil Kumar Sethi, Moh Sim Wong, E. Shyong Tai,Shih Ling KaoPII:DOI:Reference:

S0009-9120(15)00066-1doi: 10.1016/j.clinbiochem.2015.02.012CLB 8969

To appear in:

Clinical Biochemistry

Received date:Revised date:Accepted date:

26 December 20143 February 201523 February 2015

Please cite this article as: Loh Tze Ping, Sethi Sunil Kumar, Wong Moh Sim, Tai E.Shyong, Kao Shih Ling, Relationship between measured average glucose by continuousglucose monitor and HbA1c measured by three dierent routine laboratory methods,Clinical Biochemistry (2015), doi: 10.1016/j.clinbiochem.2015.02.012

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ACCEPTED MANUSCRIPTTitle: Relationship between measured average glucose by continuous glucose monitor

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and HbA1c measured by three different routine laboratory methods

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Category: Full Research Paper

Author: Tze Ping Loh,a* Sunil Kumar Sethi,a Moh Sim Wong,b E Shyong Tai,c Shih

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Department of Laboratory Medicine, National University Hospital, Singapore.Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore.

Department of Medicine, National University Hospital, Singapore.

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*Corresponding author

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Ling Kaoc

Tze Ping Loh

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National University Hospital, 5 Lower Kent Ridge Road, 119074 Singapore.

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Phone: +65-67724345

Email: tploh@hotmail.com

Running title: HbA1c and average glucose

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ACCEPTED MANUSCRIPTAbstractObjectives

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The relationship between glycated hemoglobin A1c (HbA1c) and average glucose hasbeen described by the empirically derived estimated average glucose (eAG) equation

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in the A1c-derived Average Glucose (ADAG) study, with extensive calibration effortsin four secondary reference HbA1c methods. It is not known if this relationship ispreserved when HbA1c is measured by routine laboratory methods under routine

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conditions.

Design and Methods

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We measured average glucose (mAG) by six days of continuous glucose monitoringin 45 adults with stable HbA1c (