bipolar (theories and treatment)

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    BIPOLAR:

    THEORIES AND TREATMENT

    Princess Zena M. Avery

    III-9 BS Psychology

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    Biological

    Psychological

    Theories of Mood Disorders

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    Biological Theories of Mood Disorders

    Genetic Theory

    Disordered genes predispose people to depression

    or bipolar disorder.

    Family history studies

    Family history studies of people with bipolar disorder

    find that their first-degree relatives have rates of both

    bipolar disorder and unipolar depression at least two to

    three times higher than the rates of relatives of people

    without bipolar disorder.

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    Twin Studies

    Twin studies of bipolar disorder have shown that the

    probability that both twins will develop the disorder, or

    its concordance rate, is about 60% among monozygotic(identical) twins, compared with about 13% among

    dizygotic (non-identical) twins.

    -- Specific Genetic Abnormalities

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    Neurotransmittertheories

    Dysregulation ofneurotransmittersand their receptorscauses depression

    and mania. Themonoamineneurotransmitters-norepinephrin,

    serotonin, anddopamine- have beenmost researched.

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    Neurophysiological

    (Brain) Abnormalities

    Abnormalities in the

    structure and

    functioning of theprefrontal cortex,

    hippocampus,

    anterior cingulate

    cortex and amygdala.

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    Neuroendocrine abnormalities

    Depressed people show chronic hyperactivity in

    the hypothalamic-pituitary-adrenal axis and slow

    return to baseline after a stressor, which affectsthe functioning of neurotransmitters.

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    Psychological Theories of Mood

    Disorders

    (The psychological theories of depression have focused

    on aspects of the environment, of thinking and of a

    persons past.)

    Behavioral theories LEWINSOHNS THEORY

    Depressed people experience a reduction in positive

    reinforcers and an increase in aversive events, which

    leads to their depression.

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    LEARNED HELPLESSNESS THEORY

    Depressed people lack control which leads to the belief

    that they are helpless which leads to depressive

    symptoms.

    Cognitive TheoriesAARON BECKS THEORY

    Depressed people have a negative cognitive triad of

    beliefs about the self, the world, and the future which is

    maintained by distorted thinking.

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    REFORMULATED LEARNED HELPLESSNESS THEORY

    Depressed people have the tendency to attribute

    events to internal, stable, and global factors whichcontributes to depression.

    RUMINATIVE RESPONSE STYLES THEORY

    Depressed people tend to ruminate about their

    symptoms and problems.

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    Psychodynamic Theory

    Depressed people are unconsciously punishingthemselves because they feel abandoned by

    another person but cannot punish that person;

    dependency and perfectionism are risk factors for

    depression.

    Interpersonal Theories

    Depressed people have poor relationships withothers.

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    Treatments

    Pharmacotherapy

    Psychotherapy

    Social interventions ECT (Electroconvulsive Therapy)

    rTMS (Repititive Transcranial Magnetic

    Stimulation) VNS (Vagus Nerve Stimulation)

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    Available Types of Pharmacotherapy

    Tricyclic antidepressants (TCA)

    MAOIs

    SSRIs

    SNRIs

    Atypical antidepressants

    Mood stabilizers Antipsychotics

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    Psychotherapy in Depression

    Supportive

    Insight-oriented

    Interpersonal Cognitive-behavioral

    Psychodynamic

    Individual, group or family

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    THANK YOU!!!