bipn 148 lecture 16. remembering jennifer anniston
Post on 21-Dec-2015
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BIPN 148 Lecture 16
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RememberingJennifer Anniston
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Activate Visual and Auditory Neurons
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Stimulate Hippocampal Neurons
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Visual Somatosensory
Olfactory
Auditory
Perirhinal Cortex
Entorhinal Cortex
Dentate GyrusCA3
CA1
Sensory RegionsOf Cortex
Perirhinal/ Entorhinal
Cortex
HippocampalFormation
Get info from cortex to hippocampus
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Stimulate hippocampal synapses
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Activate Spines
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Potentiate Synapses
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Activate CaMKII
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Phosphorylate AMPA receptors
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Phosphorylate GluR1on S831
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Insert GluR1 at synapses
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Unsilence synapses
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Use Stargazin to traffic AMPA-R
Stargazin interacts with AMPA receptors in an intracellular compartment in the cell and promotes their delivery to the cell surface. The carboxyl terminus of stargazin binds specifically to the anchor protein PSD-95 and mediates recruitment of the stargazin-AMPA receptor complex to postsynaptic sites.
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Induce gene expression
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Use CaMKIV to induce gene expression
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CRE SRE zif268
C/EBP krox20
AMPARHOMERBDNFNT-3
Arc
CBP/CREB
CaMKIV + ERK
Elk-1
RSK2
Express new genes
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New gene products or
proteins
Signal to
nucleus
New gene products or
proteins
Synaptic Potentiation
Locally generated tag captures new gene product
Synaptictag
NMDAR
Send gene products to synapse
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RememberingJennifer Anniston
Activate visual & auditory neurons
Stimulate hippocampal neurons
Change synaptic strengthby inserting AMPA receptorsInduce gene expressionStabilize change in synaptic strengthRecall image with visual cueDon’t confuse with Angelina Jolie