Biotech.Obs® Analytical Solutions

AGUIDEL Consulting

68 Bld Port Royal, 75005 Paris France

www.aguidel.com

Biotech vs. Bioindustry

• Biotech not reducible to « biotech start up »

• From suppliers to consumers

• SMEs+Firms+ start up

• Catalytic tools: science parks/ Incentives/ incubators/ genopoles/ canceropoles etc…

Bioindustrycase studies /assets

• SMEs in MP

• Inserm

• Panorama

• CRITT Brittany

• International/global networks

Proposals

• Regional accurate and validated data base

• Assets assessment : – Technology platform/Collaboration platform– Networks (marketing, science, technology

driven)

• Dashboard (Real time)

• Tools accessible from SMEs to civil servants and politicians.

Sources/Network

• DRRT

• CR and local

• Unions

• CES

• CCI

• ANVAR

• etc

Data

• Data Collection

• Data Warehouse

• Data Analysis

• Reporting & Communication

Methods/Traditions/Solutions

• Statistics / Data Mining• Textual Analysis Tools / Text Mining• Web Cartography• Scientometrix• Tools for Qualitative Data Analysis• Social / Socio-Technical Networks• GIS• Etc ?

Back Office

Patents

Actors

Literature

Links

ProductsProjects

J ohnson & J ohnson

Glaxo SmithKline plc

Aventis

Wyeth

Merck & Co. Inc.

Roche

Bristol-Myers Squibb Co.

Schering-Plough Corp.

Pfizer

Novartis

Pharmacia

Eli Lilly and Co.

Bayer AG

AstraZeneca

Abbott

NETWORK ORIENTED DATABASE

TechnologiesClusters

Design of Analytical Solution

Back Office

- data tables- web crawler- matching tools- tools for textual analysis- tools for data update and control

Front Office

Middle Office

- a layer of analytical queries - pre-defined queries for multilevel -data aggregationand synthetic analysis and indicators

- graphical/analytical interfaces (GIS, Relational Mappings, Statistical Charts)- statistical tables, indicators and textual synthesis- integrated querying tools

ON-LINEOFF-LINE

DATA UPDATE FEED-BACK

“Online” Data Collection Tool

Front Office “Desktop”

0

50

100

150

200

250

300

350

cancer familyhistory

risk factors hormonal-contraception

personalmedicalhistory

family relatives environment-tobacco

cancer genes

Front Office “Online”

Scientometrix

PubMed (Medline)

ISI

Derwent

Scientometrix

1

10

100

1000

1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003

20Proceedings of the National Academy of

Sciences of the United States of America

22Environmental Entomology

23Biofutur

23Current Science

26Euphytica

27Science

28Molecular Breeding

30OCL - Oleagineux, Corps Gras, Lipides

32Nature Biotechnology

32Transgenic Research

33Molecular Ecology

33Nature

37Biotechnology and Development Monitor

41Theoretical and Applied Genetics

98Journal of Economic Entomology

N. Art.Top Journals

20Proceedings of the National Academy of

Sciences of the United States of America

22Environmental Entomology

23Biofutur

23Current Science

26Euphytica

27Science

28Molecular Breeding

30OCL - Oleagineux, Corps Gras, Lipides

32Nature Biotechnology

32Transgenic Research

33Molecular Ecology

33Nature

37Biotechnology and Development Monitor

41Theoretical and Applied Genetics

98Journal of Economic Entomology

N. Art.Top Journals

selectable markers

biosafetyOil plants

rape

weeds

herbicides

herbicide resistance

gene flow

Insect pests

pest resistancegenes

gene expression

agricultural entomology

risk assessment

release

control

plant pests

glufosinate

maize

Pest control

transgenics

potatoes

reviews

resistance

interspecific hybridization

plant pathogensplant pathology

food safety

wild relatives

polymerase chain reaction

plant diseases

tobacco

foods

DNA

stimulant plants

plant breeding

hybridization

risk

disease resistance

molecular genetics

soyabeans

Biology

pollen

entomopathogenic bacteria

root crops

genetics

toxins

glyphosate

nontarget effects

legislation

natural enemies

environmental impact

sugarbeet

Pathogenstomatoes

cereals

intergeneric hybridization

enzymes

regulations

bacterial insecticidescultivars

toxicity

rice

entomopathogensvegetables

tolerance

chemical control

pesticides

gene transfer

insect control

public opinion

coat proteins

plant genetic resources

biological control agents

dispersal

biological control

seed production

survival

genetic markers backcrossing

larvae

detection

sugar crops

weed control

phosphinothricin acetyltransferase

microbial pesticides

swede rape

pollination

parasitoids

lectins

insecticides

nucleotide sequences

trypsin inhibitors

ecology

analytical methods

volunteer plants

introgression

proteinase inhibitors

European Union

Herbicide resistant weedscrop plants as weeds

reporter genes

methodology

plant pathogenic fungi

labelling

nontarget organisms

allergens

flowering

plant parasitic nematodes

invasion

lines

evolution

food allergies safety

oilseed plants

growth

effects

promoters

plant pathogenic bacteria

agglutinins

genomes

fruitsfood products

models

leaves

consumer attitudes

contamination

marker genes

population dynamics

beta-glucuronidase

population genetics

Potyvirus

proteins

food legislation

Mol. Biol. and Virol.

Detection

Agr. entomology

Weed management - geneflow

GM Food safety

Scientometrix / Adds: Actor/Networks Actor/Networks

Aventis

Glaxo SmithKline plc

Johnson & Johnson

Roche

Pfizer

Novartis

Bristol-Myers Squibb Co.

Abbott

Pharmacia

Wyeth

National Institutes of Health

Eli Lilly and Co.

Genzyme Corp.

AstraZeneca

Merck & Co. Inc.Elan Corporation plc.

Applera Corporation

Chiron Corp.

Bayer AG

Amersham Pharmacia Biotech

Monsanto

Merck KGaABaxter International inc.

Schering AGSchering-Plough Corp.

Celltech Group plc

Genentech Inc.

Incyte Genomics

Boehringer Ingelheim EI DuPont de Nemours & Co. Inc.

Perkin Elmer

Amgen

Sanofi-SynthelaboBecton Dickinson and Co.

Novo NordiskShire Pharmaceuticals Group plc

Pharmacopeia Inc.

BASF

IVAX Corporation

Mitsubishi Group

Millennium Pharmaceuticals Inc.

University of California

Akzo Nobel NV

Medarex Inc.

Tyco International Ltd.

Affymetrix Inc.

Procter & Gamble Co.

Harvard University

MedImmune Inc.

Massachusetts Institute of Technology

Solvay Pharmaceuticals incChugai Biopharmaceuticals Inc.

Biogen Inc.

Mds Inc.

Johns Hopkins University

Biovail Corporation

Corixa Corp.

Stanford University School of MedicineMedtronic Inc.

Vertex Pharmaceuticals Incorporated

Watson Pharmaceuticals Inc

Harvard Medical School

Sequenom Inc.

University of Texas Interneuron

Fujisaw a Healthcare INCLigand Pharmaceuticals

ISIS Pharmaceuticals Inc.

Bio-Technology General Corp.

Lion Bioscience AG

Cytogen Corp.Schw arz Pharma AG

QUIDEL Corp.

Allergan INC.

Abgenix Inc.

Cardinal Health Inc.

Acambis plc

Teva Pharmaceutical Industries Ltd

Yamanouchi Pharmaceutical Co. Ltd.Lexicon Genetics Incorporated

Degussa AG

Cell Pathw ays Inc.

Corning Inc

Applied Biosystems Group

SankyoCephalon Inc.Takeda Chemical Industries Ltd

ICN Pharmaceuticals Inc.

Duke University Health SystemDyax Corporation

Xoma ltd.

SkyePharmaOSI Pharmaceuticals Inc.

Nycomed Amersham plc.

King Pharmaceuticals Inc

Xenova Group plc

ArQule Inc.

Genome Therapeutics Corp.

Aurora Biosciences Corp.

Valentis Inc.

0%

1%

2%

3%

4%

5%

6%

7%

8%

0% 2% 4% 6% 8% 10% Density

Cen

trality Pharma Group I

Central, Star-like hierarchical networks

Pharma Group IILess central, Less hierarchical

Platform Tech. CompaniesClique-like, complex networks

Mapping of Collaborative NetworksWeb Tool Box for Heterogeneous Data Analysis

Andrei Mogoutov | AGUIDEL Paris - www.aguidel.com - andrei@aguidel.com

Sources: Bibliographical Databases: PubMed (Medline), ISI etc

Heterogeneous Network OutputAnalysis & Mapping: Co-Authorship NetworksContent Analysis – Keyword MappingHeterogeneous Networks Authors vs KeywordsStatistical tables and row data downloadable for desktop tools

SVG Mapping Output

Web Cartography Online Demo: Aguidel Web Toolbox

Evolution of collaboration Networks

MATERIEL_ET_EQUIPEMENT_POUR_LA_RECHERCHE BIOPROCEDE

BIOLOGIE MOLECULAIRE

SANTE_HUMAINE

BIOLOGIE CELLULAIRE

ALIMENTATION_ANIMALE

PHARMACOLOGIE

SANTE_ANIMALE

CHIMIE

BIOLOGIE VEGETALE

PRODUCTION_VEGETALE

COSMETIQUE

ALIMENTATION_HUMAINE

BIOINFORMATIQUE

DIAGNOSTIC

TRANSGENESE

ENVIRONNEMENT

MICRO_NANOSCIENCES

MICROSCOPIE

IMAGERIE

MATERIEL_SCIENTIFIQUE

Technology vs. Sector mapping of French biotech