Engineering: a key knowledge for boosting the competitiveness of biotechnology-based companies:

PRODINTEC – Introduction

Date created: October 2004. Formed as a private non-profit. Board composed of private companies in Asturias, University and Government of the Principality of Asturias. Location: Science and Technology Park of Gijón (Asturias) Delegation in Madrid: Science and Technology Park of Madrid, PC 28760 Madrid

Tarjet

Enhancing competitiveness of enterprises through the application of technological advances both their products and their manufacturing processes and management.

The bridge between research & innovation Tarjet: the market

Research

Spain: - 9º worldwide position - 3,3% scientific production

Fuente: SCImago, Scopus, ISI, Thomson Reuters

Innovation

Fuente: The Global Competitiveness Report 2011–2012

http://www3.weforum.org/docs/WEF_GCR_Report_2011-12.pdf

39º worldwide position 36º in Europe

What is the reason?

Who would go?

What steps do I follow?

How I can have functional prototype

pre-series or commercial?

How I can industrialize my idea?

• Improving the quality of life of individuals and society

Why innovate in Biotechnology?

Technologies, techniques, tools, equipment, devices, medical and surgical procedures, information systems, health programs, organization forms for the prevention, diagnosis, treatment and rehabilitation.

DEMAND AS SOCIETY

THE ECONOMY AS REQUIRED

TECHNOLOGY ALLOWS

HEALTH

• From the research to the market

- Companie - Research group - Spin Off - Hospital - Tech Based companies

Estrategic Definition Producto definition

Conceptual Design Concept generation

Detailed design Specification, assembly drawings, prototypes

Product Engeneering Technical Solution and Manufacturing drawings

Production Manufacturing Process definition

Merchandising

CD DD PE P M ED

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Licensee

Law firm

1. Detect potentially interested 2. Contact potential applicants 3. Negotiations and drafting transfer agreement

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VIABILITY, INTELECTUAL PROPERTY RIGHTS

Value chain

• Provide technical support from invention / patent to the market.

• Provide technological muscle for design and manufacturing process to provide "value" to the contact process, selection and negotiation with a licensee end.

- "Convince" the licensee of the technical end.

- Checking the operating principle and development prototypes to assist in this process.

• Cover the gap between the licensee and technical office, production and commercialization.

- Provide tools that facilitate the industrialization and placing on the market

Objetives

IVD: Kits and diagnostic devices, sensors, microfluidics, etc.. Detection and measurement of biochemical and biological parameters, identification of toxic substances, drugs, etc.. Biomedical engineering: Surgical tools, implants, custom designs, accessories, new features, etc.. Food Biotechnology: Systems for use in situ detection of contaminants or pollutants detection of biological agents. Biosensors / Equipment / Instruments: Prototypes (first series, enclosures, laboratory equipment, cells, interfaces, developing analytical instrumentation, robotics). Security and Defence: Devices for the detection of biochemical weapons, explosives, and drugs, etc..

Biocatalysis/ Bioreactors Scale-up, Industrialization, bioreactors design and manufacturing, etc.

Applications

Predica Model

PRODUCT DESIGN

PRODUCT ENGINEERING

PROCESS ENGINEERING

INSPECTION PROCESSES

MANUFACTURING TECHNOLOGIES

INNOVATION PROCESSES

Areas of activities

Future

Biomedical Models

Generation 3D Modeling

and CAD

Patient/Model

Choice of technology and

manufacturing

Rapid production of 3D models at low cost. Time reduction interventions, better communication and decision making, precise adjustment of implant training. Applications

Tools, Implants, orthopedic, …

Generation 3D Modeling

and CAD

Need, implementation,

//Know how/Idea

Choice of technology and

manufacturing

Medical Devices, PoC, Biosensors, …

Mechanical design and

generation of CAD

Protocolo

Electrical and electronic

design of the device,

reading system, control,

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Choice of technology and

manufacturing Test Product

Equipment, Instruments, Machinery…

Mechanical design and

simulation

Need / New functionality /

Machinery ad hoc

Electrical and electronic

design of the device,

reading system, control,

...

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Choice of technology and

manufacturing Test Product

3D modeling and design

of components

+

Case Studies Complete redesign and manufacture a set of instruments for bone surgery highly innovative

Case Studies Design and manufacture of a diagnostic device and electrochemical detection. Objective: miniaturization, microfluidics [capillary electrophoresis chips], portable, communication USD / Bluetooth.

Case Studies Instrumentatión Rakes

Instrumentation rakes or combs.

- Pressure and temperature probes - To manufacture complex parts - Withstands high temperatures Manufacture:

- SLS part made by Inconel - Polished finish - Manufactured in one piece

EOSINT M-270 EOS FORMIGA P-100

Machine Fabrication of direct metal laser sintering: Able to work with steels, stainless steels, cobalt chrome, brass, titanium, etc.. Layered fabrication technology that can produce finished parts from 3D CAD and metal powders. Typical applications: complex geometric parts, tools, molds with conformal channels, custom inserts, prosthetic devices, etc..

Manufacturing Machine direct laser sintering of plastics: Able to work with plastics, nylons, etc.. Layered fabrication technology that can produce finished parts from 3D CAD and polymeric materials. Typical applications: complex geometric parts, machinery parts and small series without making molds, etc..

EOS P-395

Equipment

EOSINT M-280

Aplications

OBJECT CONNEX 500 EDEN 330 multijet

Rapid Prototyping: Prototyping PolyJet technology by injection consisting of photoresists and later cured by ultraviolet light. Direct connection to CAD and engineering software reverse PRODINTEC

Rapid Prototyping: Prototyping PolyJet technology by injection consisting of photoresists (possibility of use of 2 different polymer resins simultaneously) and later cured by ultraviolet light. Direct connection to CAD and engineering software reverse PRODINTEC

Equipment

Aplications Industries Materials Case Studies

ZCORP Z510 MCP 4/04

Vacuum Casting: Making pre-series in plastic and metal from a physical part.

Rapid prototyping, prototyping based on material by dust and its suburbs by colored liquid. Infiltration finish with cyanoacrylate (getting very hard piece) or epoxy resin (flexible piece collection).

Equipment

Aplications Industries Case Studies

KERN Evo Wittmann-Battenfeld

Microsystem50

Microinjection machine, that allows the injection of plastic parts, metal and ceramic micro geometries, handling, quality control and automatic blister packaging clean room.

Micromilling machining by chip removal in high speed, to obtain absolute accuracies in the vicinity of one micron. Applications in the field of micro and nanotechnologies

Equipment

Micromilling Microinjection

Deckel Maho

Milling fully equipped robotic cell for automated manufacturing via the machining of large parts (measuring up to several metres), with accuracies of tenths of a millimetre and in materials such as resin, wood, expanded polystyrene, etc. We also have a high-speed 5-axis milling machine that allows us to produce very high precision parts with complex geometries in any material

Mecathronics CemLab

Electromagnetic Compatibility Laboratory: Performing

compatibility tests or external devices developed at the Center for CE marking

Mechatronics: Design and development of electronic circuits. Instrumentation, control and measurement. Process automation. PCB prototyping equipment.

Equipment

In short…

1.- Full development of device from companies know how to prototype or functional first series. 2.- Manufacturing direct piece further tools and functionalities in teams. 3.- Design and manufacture of machinery and devices for analysis, sensors and biosensors for diagnosis. 4.- Design and manufacture of interfaces, cells supports analysis kits ... 5.- Manufacture of medical model to patient. 6.- Design and manufacture of devices for detection and sampling. 7.- Unlocking the design constraints of traditional manufacturing processes. 8.- Access to new market niches. 9.- Reduce costs in small series. 10.- "Mass customization", batch unit, as ... EXAMPLES OF APPLICATION medical implants, orthopedic products, support structures, surgical tools, diagnostic devices, interfaces, flow cells, envelopes, microarrays ....

EKA

International Projets

ESTIIC RFID4SME

NANO4M www.nano4m.eu/

INTERREG

Frame Program

FP6: Syntex www.syntex.or.at/

FP7: Light-Rolls (coordinador) www.light-rolls.eu/

FP7: NANOfutures (CSA)

FP7: CIS3D (NMP)

Technology Platforms

Rapid Manufacturing European Plaftorm

Prodintec manager is a board member European Technology Platform Manufuture Platform manufacturing technologies. In his likeness created the regional platform PRODINTEC Manufacturias MINAM +NANOfutures Micro and nanofabrication platforms Prodintec Manager is a board member

Prodintec also a member of: Iberian Red RICAI Center for Innovation, Red PYMERA, Europe InterCluster, HISPAROB Spanish Technology Platform on Robotics and Technical IDESA Consortia

International Presence

Our Team and facilities

Centro tecnológico para el diseño y la producción industrial

PRODINTEC

EDIFICIO CENTROS TECNOLÓGICOS

PARQUE CIENTÍFICO Y TECNOLÓGICO

33203 GIJÓN. ASTURIAS

T +34 984 390 060

F +34 984 390 061

www.prodintec.com

DELEGACION EN MADRID

T +31 667 728 947

www.prodintec.com