biosocial research: biological data quality issues
TRANSCRIPT
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Methodological considerations
• Biosocial research framework
• Biological data quality issues
• Missing data in biosocial research
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Biological Data in Social Surveys• Does the mode or collection condition influence
levels of biomarkers?
• What Quality Control (QC) processes are important?
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Investigating mode/ collection conditions
A number of biosocial studies tend to use two methods to collect biomarker data:• Clinic collection: participants are invited to a clinic where blood
samples are collected and stored/processed immediately • ALSPAC • National Study Health and Development (NSHD) @63 • Hertfordshire Cohort Study• Whitehall II
• Home Nurse visit: participants are visited at home; blood samples are collected and posted to the laboratory • Understanding Society: UKHLS • Southampton Women’s Study • National Child Development Study • NSHD@53• Health Survey for England• English Longitudinal Study of Ageing
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Clinic vs home visit biological data
• Ideal sample collection conditions (usually in a clinical setting):– Venepuncture to collect blood sample
– Immediate sample processing
– Immediate analyte measurement or storage in a -80 freezer
• Typical sample collection conditions (usually in population surveys):– Venepuncture to collect blood sample
– Delayed sample processing and storage
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Are collection conditions important?
Clinic vs Home
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Daily variation: many biomarkers vary by time of day
Bi-modal distribution of nurse visits
Diurnal variation in cortisol
0 0.5 2.5 8 12 16
normal
stressed
'burnout'
Hours since awakening
nmol/L
Understanding Society: The UK Household Longitudinal Study
https://www.understandingsociety.ac.uk/
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Title | Date
Quality control Data on biomarkers
Internal and external Quality control (QC) processes
Internal: - Some biomarkers have impossible values- How well do measurements compare across
time within a laboratory (ie does a sample measure the same if the measurement is made on day ‘a’ as it does on day ‘a’+1).
- Measured through intra-assay coefficient of variation
- Less than 5% is within acceptable limits.
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Title | Date
Quality control Data on biomarkers
External quality control reflects how the laboratory compares to other laboratories measuring the same analyte. -Measured through the standard deviation index (SDI) an index of total error, including components of inaccuracy and imprecision- lower values of SDI suggest more accurate measures- score below 1 SDI is good, and between 1-2 SDI is acceptable
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C-Reactive Protein (CRP)
• Systemic inflammation: 3-10mg/L
• Current/recent infections: >10mg/L (often excluded)
• In general, CRP levels of over 3mg/L are considered as
levels that are high risk for Cardiovascular disease.
• CRP is influenced by medication: anti-inflammatory
medications, statins and contraception and hormone
replacement therapy
Specific biomarkers: methodological considerations
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Distribution of C-Reactive Protein (CRP)
by gender
Notes: Excluded cases with CRP>10mg/L
0.1
.2.3
.4.5
De
nsity
0 2 4 6 8 10c reactive protein (high sens) mg/l
kernel = epanechnikov, bandwidth = 0.2146
Males
0.1
.2.3
.4
De
nsity
0 2 4 6 8 10c reactive protein (high sens) mg/l
kernel = epanechnikov, bandwidth = 0.2635
Females
Understanding Society: The UK Household Longitudinal Study https://www.understandingsociety.ac.uk/
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Methodological considerations when analysing biological data
• Consider:
– normal ranges of biological variables (if available)
– identify outliers
– relevant medication use
– transformations (for skewed biological dependent variables)
– context of blood sampling like time of day, room temperature, recent operations, smoking, food & alcohol, etc
– quality control processes in producing biological data