biosensor using aptamer
DESCRIPTION
Biosensor using aptamer. C ontents. What is biosensor? What is aptamer ? How can we use aptamer ? How can we find aptamer ?. What is Biosensor?. Analytical device using biological element Sensing organic molecule’s state or concentration. Biomarker of Heart attacks. - PowerPoint PPT PresentationTRANSCRIPT
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Biosensor us-ing aptamer
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ContentsWhat is biosensor?What is aptamer?How can we use aptamer?How can we find aptamer?
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What is Biosensor?• Analytical device
using biological element
• Sensing organic molecule’s state or concentration
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Biomarker of Heart attacks
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What is aptamer?
• Piece of single strand DNA or RNA
• High affinity for cer-tain molecule
• Used for bioreceptor of biosensor
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• Small size easy production, modification
• High stability easy to handle, regeneration
• Economically efficient
• No immune rejection response
• Adjust to many toxic material or complex pro-
tein
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How can we find aptamer?
vitro selection
SELEX(Systematic Evolution of Lig-ands by Exponential Enrichment)
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Different kind of SELEX Cell SELEX
Capillary electrophoresis SELEX (CE SELEX)
Speigelmer
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How can we use aptamer?Sensor
Diagnosis
Cure
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DiscussionWhere can aptamer be used in
another way?
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Reference 장승훈 , 정기준 , 압타머 (Aptamer) 개발의 최근 연구 동향 ,
한국과학기술원 생명화학공학과 Li Cai, Ze-Zhong Chen, Min-Yan Chen, Hong-Wu Tang*,
Dai-Wen Pang, MUC-1 aptamer-conjugated dye-doped silica nanoparticles for MCF-7 cells detection, 2013, Biomaterials
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Thank you!!