Biomoleculary background of Biomoleculary background of hypertensionhypertension

science is indeed the smart arttofindthe essence ofthe science is indeed the smart arttofindthe essence ofthe

complicated and difficult phenomenon, to be simplified and complicated and difficult phenomenon, to be simplified and then can beunderstood by othersthen can beunderstood by others (Albert Einstein 1917) (Albert Einstein 1917) POSTULATICBACKGROUND :1. Bio-organic 2. Biocellular 3. Biomolecular overlapping area teleologic

paradigm ioorganic BiocellularBiomolecular

Biogenesis, evolution based on the

natural physical laws The law of cosmic balance and biologic orderThe essence The fundamental physical laws of naturetrias existentialism, equilibrium, dialecticism, interdependency, feedback mechanism, the sum of zero, the limit of growthand effectiveness,thestruggle for survival, uncertainty principleThe contradictionor deviation toward thefundamentalphysical lawsof naturecalled disorder orthe disease.C!"# nucleus$%&.&&&'ndothermicbiochemistry(t!"#'xothermic biochemistry$. oxidant). 'nergy"o repairy (t!"#!ecreasing energy $.#gingprocess). (ets*. #utoimmune disease+. ,unctional disbalancing%. #poptosisThe cell$-.p.)* B./(/0'C10#2 #"! (.T/C3/"!2.#('!.C."' $. 4upportingtheparadigma of normative biocellular appliedmedicine). 3aving its own idea of Teleologicbiomolecular 5 mitochondriaapplied medicine367'2T'"4./"C#2!.#C /1T71T x 7'2.73'26

2'4.4T'"C6 $."atriuresis $. c!"# arrangement pressure disorder). /besity). 0ack of nephron*. 'ndothelial cytocine*. 4tress+.4tress %.2##4

AngiotensinogenAngiotensinogen renin. renin.ToninToninAngiotensin-1 Angiotensin-1CathepsinACE CathepsinACEt-PA Chymase t-PA ChymaseCAGE CAGE

Angiotensin-II Angiotensin-IIAt-1 R dan At-2 R At-1 R dan At-2 Rcortex glandula suprarenalis cortex glandula suprarenalisA!"P#$ A!"P#$nuclear %actor&appa 'nuclear %actor&appa ' At-Reseptor adiposit ( 1).p.1*+ At-Reseptor adiposit ( 1).p.1*+Inhi,it the production o% ACE Inhi,it the production o% ACE3epar#dipocyte $*.p.$&%gamma77#2 adipositokin $. ,,# ). leptin*. adiponectin. -. pre-angiotensin +. il-.&ongenitalC-A/P 0 c-G/PPeptida G 0peptida P1el glia ( catecholamin 0 acetyl cholin1omatopro2ac center 3 circulus 1echeno4i22.p.526 22.p.72 in coordinating EC/1).p.1*+ in adipocyte!ys%unctional ,aroreceptor 8 chemoreceptor "ephron 5 natriuresis mechansm EndotheliaTunica media1tressCardiac outputvs peripheralresistencyaldosteronobesity(t!"#7roducen of energy$./xydized "#!3 8 2educed obequinon*.2edox /bequionon 8 C cytochrome 2edoxC cytochrome9: ten enzyme; +.: ten 8 &) #T7 ase9 #(7 to be#T7 ;).4uccinat/bequinono !A Endonuclease !A polymerase !A ligase material for promoting (1. 1peci%ic amino acidArginin6 asparatic acid6 cystein6 alanin glutamic acid6 glycine6 histidin6 proline6 serine6l-thyrosine). large amount glycine 7reventing the- destroyers8 antioxidants3ypertensive syndrome < one of the mala=ustment of the disbalancing function between the (t!"# andthe c!"#

Hopeful Powerful Amazing dream Thank you for yourattention.f the biologic order does not deviate from the fundamentalphysical laws of nature. >enetic rearrangement,oetal programBlastula state.nterdependency0aw ? ontogeny vsmother@ endometrium 9Biopsychosocial;>enetic deviation$. $-.p.)* dysfunction). 3ereditary*. $*.p.$&%+. Centromere 5 Telomere%. Coordinating c(ic, c'rb$, c'rb)$.c-A/P4sc-G/P ). peptida G 0 peptida P*. Glia cell %unctioning %or catecholamin0 acetyl choline+. decreasing %unction o% 1omato-pro2ac center%. 1).p.1*+ innephron ontogeny A. 22.p.52 8 22.p.72in %orming EC/ -. !ys%unctioning,aroreceptor 8 chemoreceptor

nucleus arcuatus42 .2,insulin re9c#(7; ceptor, alpha (43 receptorleptin9c>(7; 7eptida >"europeptida 6"europeptida #gadiposit77#2 gama receptor>en $*.p.$&%#dipositokin$. ,,#). 0eptin*. #diponectin+. 2esistin%.#ngiotensinogen, #C', #t2 A.7#.$ -.7>#2 B.alpha T",, .lA 7eripheral resistencyobesityRAAS, ENDOTHELIAL CYTOCINE RAAS, ENDOTHELIAL CYTOCINEHEPATOCYTE HEPATOCYTEADIPOCYTE ADIPOCYTEANGIOTENSINOGEN ANGIOTENSINOGENPNEUMATOCYTE PNEUMATOCYTE

1. CATHEPSINRENIN 1. CATHEPSINRENIN

2. TONIN2. TONIN

3. T-PA 3. T-PA ANGIOTENSINI ANGIOTENSINI1. ACE 1. ACE 2. CHYMASE 2. CHYMASE. .

1. + At-1R + At-2 R1. + At-1R + At-2 R3. CAGE 3. CAGE

2. +CORTEXSUPRARENAL 2. +CORTEXSUPRARENAL

3. +NAD(P)H ANGIOTENSIN II 3. +NAD(P)H ANGIOTENSIN II4.+NUCLEAR FACTOR!4.+NUCLEAR FACTOR! ".+ ADIPOCYTE # 13.P.1$" ".+ ADIPOCYTE # 13.P.1$"

%.-ACE %.-ACE

ALDOSTERON ALDOSTERON

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2 2.. 50&-&'3'6t-& 50&-&'3'6t-&

T'1'/3'6,01-/ T'1'/3'6,01-/3.C,'.-&'3'6t-& 3.C,'.-&'3'6t-& 4./')&-/ +/t'&/)/3+01+( 4./')&-/ +/t'&/)/3+01+((7.60t,'t+3 0(3'/*'/ (7.60t,'t+3 0(3'/*'/

D+'/3'6,01-/D+'/3'6,01-/ 1. T,010.)( 1. T,010.)(1. S7.60t,'t+3 3'/t'& 1. S7.60t,'t+3 3'/t'&2. H76-t,010.)( 2. H76-t,010.)(2. /)31')( 0&3)0t)( 2. /)31')( 0&3)0t)(3. T,7&'-t&-6+/ 3. T,7&'-t&-6+/3. H76-6,7(' 3. H76-6,7('4. ACTH 4. ACTH". 80(-6&'((+/ 9 ADH 4. E6+6,7(' ". 80(-6&'((+/ 9 ADH 4. E6+6,7('%. 60/3&'-t&-6+/%. 60/3&'-t&-6+/ Centrum somatopro2ac in4ersiENDOTHELIALRECEPTOR ENDOTHELIALRECEPTORAt-1 RA-2RA&-3RAt-4R/)t&+t+-/ R At-1 RA-2RA&-3RAt-4R/)t&+t+-/ R1. 1.Chol:HDL Chol:HDL2. LDL:HDL 1.Atorvastatin Cell 22.p.72 et 92 2. LDL:HDL 1.Atorvastatin Cell 22.p.72 et 923. LDL:Apo B 2. imidapril 3. LDL:Apo B 2. imidapril4.Gluose ! 1"#3. Gl$ine 4.Gluose ! 1"#3. Gl$ine". %&idant:Antio&idant4. aeth$l holine ". %&idant:Antio&idant4. aeth$l holine'. (on Ca ".)iranda itro*olianutrition$toine'. (on Ca ".)iranda itro*olianutrition$toine 7. Homo$stein '.L+Ar,inin 7. Homo$stein '.L+Ar,inin-. )t+D.A:+D.A -. )t+D.A:+D.A9. Auto+immune 9. Auto+immune1#.Hs+C/0 1#.Hs+C/011.Central hormonal1nutrition$toine11.Central hormonal1nutrition$toine / /peripher$ hormonal peripher$ hormonal12.An,iotensin ( 12.An,iotensin (13.(n*eted vas2ulitis 13.(n*eted vas2ulitis14.3mo2in, pinotosis414.3mo2in, pinotosis4 oo2in, asoo2in, as

1".0s$ho,eni distress 1".0s$ho,eni distress1' (oni5in, radiation1' (oni5in, radiation17. De,eneration proessmessen,er17. De,eneration proessmessen,er $toine 4$toine 4

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