biomedical autism treatment - yes, it could help your autistic child!
DESCRIPTION
DOAST (Doctrine Oriented Art of Symbiotic Treatment), an integrated therapy centre for autism, Chennai is one of the best autism treatment centre in India, provides best solution for autistic children by improving their behaviour and cognition through integrated therapy. For more details,visit: http://www.autism-ent-specialist-chennai.comTRANSCRIPT
DOAST- NPK- Chennai- INDIA 1
‘DOAST Integrated Therapy’
Novel Bio-Medical approach
to
AMELIORATE AUTISM.
2004-201
3
‘DOAST Integrated Therapy’Successful in-vivo
techniquein synergy with Global
research.
Treatment Guided research which
Follows the LEADS and focuses on safe and effective interventions
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DOAST- NPK- Chennai- INDIA 3
Dr.Bernaud Rimland Authored the Neurobiological
approach.The First
POSITIVE TURN IN AUTISM RESEARCH
1964
Four decades of Global Research.Are we able to deliver peace at home?
Autism research exhibits analytical threads, but patterns remain
fragmented lacking a unified concept. As on date we lack a coherent view on brain function within the framework of
other organ systems.
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1964 to 2013
POSITIVE APPROACH of DOAST ‘Instead of studying it through a symptom by symptom approach,
autistic behavior should be understood better by studying the underlying intermediary biological
processes’
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Emerging qualitative changes in clinical status including loss of diagnosis suggest that a more
appropriate description for ASD could be a “chronic dynamic reversible
encephalopathy” rather than “static encephalopathy” as considered so far.
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“Cognitive, emotional and synaptic functions of the brain basically rely on
the macromolecular computing system of RNA protein- and protein to protein interactions which appear to be the result of fine grained information,
encoded and accumulated over evolutionary time”.
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DOAST- NPK- Chennai- INDIA 8
Autism Spectrum Disorder[ASD]
A “Two hit’ onset mechanism,
where ‘permissive genetic
landscape’ interact with a series of
environmentally destabilized
dominos.
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Behavior = Brain + Network
Neuro-Endo-Immune- GI Tract Network,
Autonomic Balance, &Neurotransmitters.
Bio feed back & Autonomic Balance
CNS-ENDO-IMMUNE-GI Tract- Network
Homeostasis
Normal Performance
Social&Cognitive, Activities
Genes,Molecular order,
Protein expression, Nerurotransmitters
Neuronal connectivity.
Behavior&Cognitive dysfunction.
Altered network
Homeostasis
Environment
Toxins
Susceptible Genetic
landscape
DownstreamSystemic
Inflammation
Upstream molecular
unrest
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AUTISM
“Decreased connectivity is at the heart of autism’.
Fairly close regions of the brains involved in motor tasks have difficulty coordinating
activity.It makes sense that social and communication
skills are greatly impaired, as they involve more complex synchronous coordination between more distant areas of the brain.
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Consequences of inflammatory factors
Breaking boundaries between the body and brain,
Destabilization and loss of synaptic connections.
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Upstream molecular
unrestDown stream inflammation
Dietary or environmental
triggers, Gut micro biome
systemic inflammatory cytokines on a chronic basis
Our Concept..
Synaptic connectivity
affected in in susceptible individuals.
Bio feed back & Autonomic Balance
CNS-ENDO-IMMUNE-GI Tract- Network
Homeostasis
Normal Performance
Social&Cognitive, Activities
Genes,Molecular order,
Protein expression, Nerurotransmitters
Neuronal connectivity.
Improved Behavior&Cognition
Restore Network
Homeostasis
Cellular Stressors
DownstreamMolecular
order
Upstream molecular
order
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INTEGRATED THERAPY
Integrated Therapy Hypothesis
Deviate from the ‘Hard wired’ concept and ‘untreatable’ stigma.
Effectively treating the ‘downstream inflammatory pathology’ could initiate reestablishment of ‘upstream
molecular order’ . Molecular order restored could activate the dormant neuronal pools, improve
connectivity and restore functional integration.
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DOAST
Hypothesis
DOAST Integrated therapy
Pioneering concept of therapeutic integration or fusion, where scientifically chosen traditional
Indian treatment methods are applied with modern medical understanding to treat specific chronic
ailments, and autism in particular.
DOAST- NPK- Chennai- INDIA
Treatment
Technique
The Components of Integrated Therapy.
The Science of Yoga, Ayurveda &Siddha &
Modern medical expertise.
DOAST- NPK- Chennai- INDIA
Reducing Cellular stressToxin elimination Rejuvenation and
Regeneration.
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Therapeutic
Concept
No reliable bio-marker. Observed improvements in behavior and cognition domains are the only reliable non-invasive indicators of restoration of molecular order and
integration of the upstream neuronal pools.
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Prognostic Evaluation
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Patient selection.
• DSM-IV guidelines, (CARS) and M-CHAT are the standard assessment tools used.
• Patient pool represents a spectrum of severity observed in autistic patients in general.
• Their racial origin is Asian. Age 3- 16 years.
• Cohort of 30 individuals on different follow up period on this therapy since 2004.
Therapeutic protocol The prescribed diet ‘Sathvik Diet’ practiced by
the science Yoga. Herbal medications, certified by the Ayurvedic
[including Siddha] pharmacopia of India are administered.
Yoga technique is a combinatorial approach. Oleation therapies with medicated oils.
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Ethical & safety guidelines followed A well informed consent, The therapy techniques and medicines are chosen
by evidence based risk benefit ratio, proven over centuries in their clinical application,
One to one & Group basis application along with the parent,
Documentation on paper and video, Pretreatment EEG and periodic monitoring of
biochemical parameters to assess renal, hepatic and hematological functions.
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Assessment of Clinical benefits
Eye contact, Play, Communication, Empathy & Generalizationare the behavior domains chosen to assess and quantify behavior and cognitive improvement.
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GI Tract,Respiratory,Sleep,Morbidity,Emotions,Behavior,Cognition.
Controls We follow each patient, from the time of admission and
through their recovery (or lack of it). Thus each participant in the study will serve as his/her own control.
Improvement is influenced by the age of induction into therapy, duration of follow-up and compliance to the details.
Parental compliance to be proportional to the trust on therapy.
Willful or accidental default in medicine or dietary regime 'influenced by the above listed ‘variables', resulted in temporary return of symptoms. Such events helped us understand the therapeutic role played by components of therapy in a better way.
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VALIDITYConsistent replication lends validity,Supports the hypothesis that chronic
inflammation could indeed be the common denominator.
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Future researchWe contemplate generating carefully characterized full
genome expression profiling data to validate our biomedical approach and to study the involvement of
the intestinal flora in the inflammation related etiology of autism.
The core of our study will be a repeated measures examination of the interplay
between the biology of inflammatory and oxidative stress markers on the one hand
and processing, connectivity and reactivity abnormalities on the other which may conceivably converge on to the autism
profile.
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Proposed Study Examine the gastrointestinal
metagenomic analysis of intestinal flora,
Non-coding RNA (ncRNA) expression profiles on lymphoblasts in a series of before and after comparison based molecular studies.
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Outcome of the proposalGenerate direct evidence in favor of a causal relationship between systemic inflammation and autism,
Generate diagnostic determinants for definition of this variant of autism,
Define a link between diagnostics and treatment by this and any future treatment technique.
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In the least invasive manner, using this DOAST treatment modality as a
physiological probe, we study the linear, causal relationship between cellular-level changes and behavioural problems within the high performance environment of the
human nervous system.
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The identification of relationships between the multiple levels, all of which can be expected to shift based on both huge amounts of clinical experience and a
growing wealth of published scientific data, will be a contribution to identifying
treatment targets that simultaneously address multiple features of autism at their
root.
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While there are risks associated with any dogma challenging proposal, the most compelling gains
of this project is that success in any of the multiple facets of this investigation will lead to
important new knowledge about epigenetic and molecular denominator based integrated
therapeutic approaches for a heterogeneous neural disorder that has so far not responded
significantly to mono therapy.
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In the research on treatment of
autism, this DOAST endeavor
aims to create a positive platform
where biomedical treatment
targets could be effectively used
to achieve functional
connectivity and independent
existence.