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5th International Essen Symposium on
Biomaterials:
Fundamentals and Clinical Applications
Essen, October 9-11, 2002
Program and Abstracts
Biomaterials 2002: Fundamentals and Clinical Applications - 2 -
University of Essen PROGRAM
5th International Essen Symposium Essen, October 9-11, 2002 Biomaterials: Fundamentals and Clinical Applications Organized by the Working Group on Biomaterials and Tissue Compatibility of the University Essen In collaboration with the Graduate school "Reactivity in the Near-Surface Range" and the Working Group Biomaterials NRW e.V.
Biomaterials 2002: Fundamentals and Clinical Applications - 3 -
Welcome to the 5th Essen Symposium on Biomaterials The organizers extend a cordial welcome to all of the participants of the 5th Essen International Symposium on Biomaterials. We sincerely hope that you will have a pleasant stay in the City of Essen, which is celebrating its 1150th birthday this year. It is our believe that this symposium will form a platform for communicating your scientific results to the biomaterial community and will stimulate your research in the years to come. We are happy that the international character of the symposium could be expanded with over ten countries being represented at the symposium this year. The future of implants lies in their surface. This holds for metallic and non-metallic biomaterials. In the case of metals excellent bulk materials such as titanium/titanium alloys, cobalt chromium and stainless steels have been developed. Some of these bulk materials shed metal ions from their surfaces possibly eliciting allergic reactions. Otherwise, the surfaces of these materials show a high degree of natural self-passivation in the presence of oxygen giving them excellent empirical biocompatiblity. Nonetheless, very little is known about the actual surface chemistry of these metals or their specific reactivity in biological media. In recent years artificial metallic surfaces of high hydrophilicity onto which cyto-mediators or drugs were immobilized have been rationally developed. Such bioactive surfaces may slowly release their bio-load in vivo leading to implant protection or locally engineered tissue for enhanced integration. It is the aim of the Essen Symposia on Biomaterials to bring together leading researchers from around the world working on the cutting edge of biomaterials science and clinical implantology to discuss and develop novel approaches to implantological therapies for the welfare of millions of patients in the time to come.
Organizers: H.P. Jennissen M. Laub H. Rumpf Organizing Committee: D. Bingmann R. Erbel A. Fischer K. Jahnke F. Löer International Advisory Committee: R.B. Heimann (Freiberg) V. Hlady (Salt Lake City) D. Grönemeyer (Witten-Herdecke) S.G. Steinemann (Waldenburg) H. Uludag (Edmonton)
Biomaterials 2002: Fundamentals and Clinical Applications - 4 -
Proceedings Volumes of Previous Symposia The previous Symposia have been published in the International Journal Materialwissenschaft und Werkstofftechnik (Materials Science and Engineering Technology).
1st International Essen Symposium 1998 Proceedings (Guest editor: H.P. Jennissen): Materialwiss. Werkstofftech., Vol. 30, pp. 731-885 (1999)
2nd International Essen Symposium 1999 Proceedings (Guest editors: A. Fischer & H. Brauer): Materialwiss. Werkstofftech., Vol. 32, pp. 109-210 (2001)
3rd International Essen Symposium 2000 Proceedings (Guest editors: D. Bingmann): Materialwiss. Werkstofftech., Vol. 32, pp. 889-1008 (2001)
4th International Essen Symposium 2001 Proceedings (Guest editors: D. Bingmann): Materialwiss. Werkstofftech., in preparation (2002)
This years symposium will also be published in a proceedings volume of the scientific journal Materialwissenschaft und Werkstofftechnik (Materials Science and Engineering Technology). Abstracts can be submitted after the symposium. Deadline will be announced.
Biomaterials 2002: Fundamentals and Clinical Applications - 5 -
Sponsors and exhibitors We are most grateful to the following sponsors who have made this symposium possible. Scientific sponsors
Fördervereinigung für die Stadt Essen
Arbeitsgemeinschaft Biomaterialien NRW e.V.
Graduate school of the University of Essen "Reactivity in the Near-Surface Range"
FET (Zentralstelle für Forschungs- und Entwicklungstransfer), University of Essen
Industrial sponsors ATMOS MedizinTechnik GmbH & Co. KG, Lenzkirch
Fahrzeug-Werke LUEG AG/ Essen
Heraeus Kulzer GmbH
Stiftsquelle Johann Spielmann GmbH/ Essen
Stryker Trauma Science and Technology, Schoenkirchen
Exhibitor L.O.T. – Oriel GmbH & Co. KG, Darmstadt
Biomaterials 2002: Fundamentals and Clinical Applications - 6 -
Miscellaneous and social events Language: The official language of the symposium is English. All abstracts should be in this language. However lectures in German are also permitted. Localities: The conference venue is located at the University Essen - Audimax (S04 T01 A02). Slide and film Facilities are available for 24 x 26 mm slides, projection simultaneous projection of: two slides, overhead projection, VHS video and Powerpoint/ Acrobat presentation. Posters: Bulletin boards for poster display: 80 cm (wide) by 120 cm (high). Exhibition: University Essen - Audimax (S04 T01 A02). Social events: Reception by the Lord Mayor of Essen and Symposium dinner (October 9, 19:00) Special Symposium event (October 10, 19:00) - Villa Hügel: Exhibition "Sense and Sensuality - Flemish still life 1550 - 1670". After the exhibition dinner at the "Dampfbier" brewery. Tickets are available at the Symposium desk (32 Euro). Symposium Prof. Dr. H.P. Jennissen Secretary's Office: Mrs. Heidi Buballa Institut für Physiologische Chemie Universität Essen, Universitätsklinikum Hufelandstr. 55 D-45122 Essen Tel.: +49-201-723-4126 Fax.: +49-201-723-4130 E-Mail: [email protected] Symposium Audimax (S04 T01 A02) Secretary Desk Tel.: +49-201-183-4477 during the Fax: +49-201-183-4646 Symposium: Homepage of the http://www.biomaterials.uni-essen.de Symposium:
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Wednesday, October 9, 2002
9:00 WELCOME
Plenary Lecture
H. P. Jennissen
9:15 Metallic Biomaterials
PROTEINS AT INTERFACES 10:00 – 11:20
S. Steinemann
Chairmen: V. Hlady, D. Klee 10:00
10:20
10:40
11:00
Protein Interactions with PEO Brushes
Protein Interactions with Heterogeneous Interfaces
Statistical Mechanical Modeling of Protein Adsorption
Surface Topography of BMP-2
V. Hlady, University of Utah, Salt Lake City
D. Britt, Utah State University, Logan
P. von Tassel, Wayne State University, Detroit
M. Laub, University of Essen
11:20 COFFEE BREAK CELLS AT INTERFACES
11:40 – 13:00
Chairmen: D. Brunette, S. Vukicevic 11:40
12:00
12:20
12:40
Regeneration Of Bone And Cartilage By Bone Morphogenetic Proteins (BMPs) And Cartilage-Derived Morphogenetic Proteins (CDMPs)
The Control of Cellular Responses by Biomaterial Topography
Cellular Motility on Implants
Biodegradable Hydrogel Implants Induce Cell Type Specific Responses
S. Vukicevic, University of Zagreb
D. Brunette, Uni- versity of British Columbia, Vancouver
L. Winkler, University of Essen
H. Hall, ETH Zürich
13:00 LUNCH
Biomaterials 2002: Fundamentals and Clinical Applications - 8 -
IMPLANT MATERIALS 14:00 – 15:40
Chairmen: A. Fischer, G. Bensmann 14:00
14:20
14:40
15:00
15:20
The Performance of Ni-free Stainless Steels for Medical Applications under Superimposed Stresses
Cobalt Chromium in Medical Applications
Entrapment of Wear Debris on Electro- chemically Microstructured Surfaces in a Metal-on-Metal Contact Situation
In Vitro Characterization of Micro- structured Titanium Implant Surfaces
Nuclear Magnetic Resonance (NMR) Studies on Plasma-Sprayed Hydroxy- Apatite Coatings: Influence of Bioinert Bond Coats on Phase Composition and Resorption Kinetics in Simulated Body Fluid
A. Fischer, University of Duisburg
A. Piotrowski, gb Implantat Technologie GmbH, Essen
R. Büscher, University of Essen
L. Scheideler, Universityof Tübingen
R.B. Heimann, Freiberg University
IMPLANT DESIGN AND SURFACE
MODIFICATIONS 15:40 – 16:20
Chairmen: H. Uludag, M. Wiemann 15:40 16:00
A Combinatorial Approach for Designing Synthetic Materials for Osteogenic Cell Differentiation: A Case Study with NiPAM Polymers Designed for RGD Grafting Biological Multi-layer Systems as Implant Surface Modification
H. Uludag, Edmonton University R. Willumeit, GKSS Research Center, Geesthacht
16:20 COFFEE BREAK
Biomaterials 2002: Fundamentals and Clinical Applications - 9 -
POSTER BREAKOUT SESSION 1 16:45 – 18:00
Chairmen: M. Laub, M. Schwarz 4 Minute Poster Exposés
Engineering with Nitinol: Characterisation and Optimisation Experimental Studies on the Interface Ingrowth Characteristics of Hydroxyapatite Coated Lumbar Intervertebral Implants Alumina Short Fibre Reinforced and Unreinforced Hydroxyapatite: Nano- and Microstructure Characterization of MD05 - A Bone Substitute Device Having Osteo- inductive and Osteoconductive Properties Tissue Reaction of Coronary Arteries after Implantation of Coated Stents with Anti-Inflammatory and Anti-Proliferative Drug Release First Analysis of Explanted Silicone Breast Implants Modification of Surfaces to Control Protein Adsorption and Cell Growth A Novel Type of Mechano-Protein with Promising Properties for Nanoscale Engineering Shear Strength of Experimental "Bone-Isoelastic" Titanium Alloys in the Ovine Femur
Importance on In-Vitro Biocompatibility Investigations by Nanocolloids from Metallic Wear in Implant Materials Therapy and Prophylaxis of Adhesion After Traumatic Right-sided Rupture of the Diaphragm - A Case Report
D. Aslanidis, @medical technologies, Belgium Y. Chen, University of Essen A. Dorner-Reisel, Freiberg University of Mining and Technology K. Hellerbrand, Scil Biomedicals, Martins- ried I. Karousssos, University of Essen A. Klocke, University of Aachen
M. Müller, Fraunhofer IGB, Stuttgart
W. Peters, University of Frankfurt (Main) A. Pingsmann, University of Essen L. Podleska, University of Essen T. Porté, Berufsge- nossenschaftliches Un- fallkrankenhaus Hamburg
Biomaterials 2002: Fundamentals and Clinical Applications - 10 -
Therapy and Prophylaxis of Periarticular Ossifications After Long-Term Ventilation - A Case Report Reducing Adhesions in Experimental Animal trials By an Antiadhesion - Foil - A Review Incorporation of Two Different Meshes for Hernial Surgery - Immunohisto- chemical and Ultrastructural Results - Porcine Heart Valve Interstitial Cells on Collagen Three-Dimensional Scaffolds: Characterization of Proteoglycans in the Newly Formed Extracellular Matrix
Structural Investigations of the Interaction of the Synthetic Peptide NK2 with Model Membranes
T. Porté, Berufsge- nossenschaftliches Un- fallkrankenhaus Hamburg T. Porté, Berufsge- nossenschaftliches Un- fallkrankenhaus Hamburg I. Schmitz, BG - Klinik Bergmannsheil, Bochum P. Vischer, Institut für Arteriosklerose- forschung, Münster R. Willumeit, GKSS Research Center, Geesthacht
18:00 End of Session 19:00 Reception by the Lord Mayor of Essen and
Symposium dinner
Address by: The Lord Mayor of Essen, Dr. W. Reiniger University Rector, Prof. Dr. K.-H. Jöckel Dean of Medical Faculty, Prof. Dr. H. Grosse-Wilde Presentation of 1st Young Scientist Award: Prof. Dr.-Ing. A. Fischer
Biomaterials 2002: Fundamentals and Clinical Applications - 11 -
Thursday, October 10, 2002
IMPLANT DESIGN AND SURFACE MODIFICATIONS 8:30 – 10:50
Chairmen: G. Fleminger/ R. Urban 8:30
8:50
9:10
9:30
9:50
10:10
10:30
Enhancement of Bone Growth by Coating of Osteoconductive Beta-Tricalcium Phosphate (Beta-TCP) with Recombinant Human Growth/Differentiation Factor-5 (rhGDF-5)
Covalent Surface Modelling of Medical Devices
A Bacterial TiO2-Binding Protein (TiBP) - Purification, Properties and Applications
Poly(vinylidenfluoride) as a Biomaterial in Bone Contact
Organization of Integrin Receptor Proteins in Response to the Material Surface Wettability
Surface Modification of a Porous TiO2/glass Ceramic
Adsorption and Desorption of BMP-2 and the Model Protein Ubiquitin on Hydrocarbon-Coated Metallic Surfaces
S. Pöhling, Scil Biomedicals GmbH, Martinsried
M. Keusgen, University of Bonn
G. Fleminger, Tel Aviv University
D. Klee, University of Aachen
G. Altankov, Bulgarian Acad. of Sci., Sofia
H.J. Erli, University of Aachen
H.P. Jennissen, University of Essen
10:50 COFFEE BREAK ADVERSE REACTIONS AND LOCAL
DRUG THERAPY 1 11:10 – 13:00
Chairmen: M. Morlock, G. Taeger 11:10 11:30
Micromotion at the Bone-Implant Interfaces Corrosion Products Generated from Interface Corrosion of Stainless Steel Implants
M. Morlock, Technical Univ. Hamburg-Harburg R. Urban, Rush-Presbyterian-St. Luke's Medical Center, Chicago
Biomaterials 2002: Fundamentals and Clinical Applications - 12 -
11:50
12:10
12:30
From Nickel-Interacting Proteins to Nickel-Reactive Human T-Cells
Porous Aluminia Coatings for Improved Bone Implant Interfaces
Comparison of Diamond-Like-Carbon and Ceramic Joint Bearings Articulating Against Polyethylene with Survivorship- Analysis
H.-J. Thierse, Max- Planck Institute for Immunobiology, Freiburg
P. Wilshaw, University of Oxford
G. Taeger, University of Essen
13:00 LUNCH
ADVERSE REACTIONS AND LOCAL DRUG THERAPY 2 14:00 – 15:20
Chairmen: J. Schierholz, L. Koole 14:00
14:15
14:25
14:35
14:50
15:00
Optimising Device Performance: the Drug- Device Interface from Development to Market
Novel Polylactide-Based Release Systems for Local Antibiotic Therapies
In Vitro Adherence and Accumulation of Staphylococcus Epidermidis RP 62 A and Staphylococcus M7 on Four Different Bone Cements
Controlled Release from the Polymer- Coated Surface of Medical Devices, Such as Wires, Coils and Catheter Tubes
Implant Related Risk Factors for Local Infection after Fracture Fixation
Different Materials to Repair an Incisional Hernias - Pro and Con
J. Schierholz, Research Center Caesar, Bonn
M. Schnabelrauch, Innovent Technologie- entw. e. V., Jena
D.P. König, Research Center caesar, Bonn
L. Koole, University of Maastricht
St. Arens, University of Bochum
M. Korenkov, University of Cologne
15:20 COFFEE BREAK
Biomaterials 2002: Fundamentals and Clinical Applications - 13 -
POSTER BREAKOUT SESSION 2 15:45 – 17:00
Chairmen: H. Rehage, R.B. Heimann 4 Minute Poster Exposés
A Laser Direct Writing Technique for Patterning of Organic Monolayers – A Fascinating Approach to New Biosensors ?! Dynamic Contact Angle Stability for Different Metal Surfaces Correlation of Particle Fluxes and Film Properties of Hard Carbon Coatings Electrochemical Studies of the Ad- sorption of Proteins on Conducting Surfaces Interaction of Natural and Synthetic Solutions with Concrete Materials Molecular Modelling Studies of the Interactions between Dystrophin and Beta-Dystroglycan Frost Dilatation and Pore System of Hardened Cement Paste under Different Storage Condition Biocompatibility of a Nickel-Free Steel (P2000) Assayed with Direct Metal Contact of Osteoblast-Like Cells Corrosion of Chemically Structured Metallic Surfaces Systemic Distribution of Cobalt and Chromium in Patients with Well Fixed and Loose Arthroplasties Langmuir-Blodgett Films of Nanosized Au55-Cluster Thin Films of BaTiO3 Prepared by R.F. Magnetron Sputtering
T. Balgar, University of Essen M. Chatzinikolaidou, University of Essen O. Filipov, University of Essen K. Gloddek, University of Aachen J. Krylova, University of Essen M. Leis, University of Essen A. Liebrecht, University of Essen M. Mölders, University of Essen A. Runiewicz, University of Essen N. Stais, University of Essen A. Vassiliev, University of Essen K. V. Reddy, University of Essen
Biomaterials 2002: Fundamentals and Clinical Applications - 14 -
Cytokine Expression of Human Donor Macrophages and Human THP-1 Leukaemia Macrophages after Challenge with Titanium Particles: Pharmacological Modulations Nickel-Specific Cytokine Production in Allergic Versus Non-Allergic Probands 3D-Reconstruction of Confocal Image Stacks: Visualisation of Live Cells in Bone Coating of Porous Bone Substitutes and of Metallic Prostheses with PALASEPT
Tissue Engineering on Natural, Biomaterial and Polymer Surfaces Adjusted to Laminar and Defined Gradient Hydrodynamics
M. Vendel, University of Essen M. Lindemann, University of Essen A. Roth, University of Applied Science (FH) Dortmund U. Gopp, Heraeus Kulzer GmbH & Co. KG, Wehrheim J. Wissler, ARCONS Applied Research, Bad Nauheim
17:00 General Poster Session 18:00 Presentation of Poster Award Prof. Dr. E. Winterhager,
Associate Dean of Research of the Medical Faculty of Essen
19:00 Special Evening Event with Dinner
Villa Hügel: Exhibition "Sense and Sensuality - Flemish still life 1550 - 1670" "Dampfbier" brewery
Biomaterials 2002: Fundamentals and Clinical Applications - 15 -
Friday, October 11, 2002 CELL COMMUNICATION AND CELL-
MATERIAL INTERACTIONS 9:00 – 10:20
Chairmen: D. Bingmann, F. Thévenod 9:00
9:20
9:40
10:00
Interactions of Osteoblastic and Other Cells with Bioactive Glasses In Vitro and In Vivo
Osteomalacia: Putative Role of Gap Junctional Dysfunctions in Bone Cells
Functional Significance of Gap Junctions for Growth and Differentiation of Bone Cells
Mechanisms of Cadmium Toxicity in the Kidney Proximal Tubule: A Tale of Traffic, Transport and Death
I. Silver, Bristol University
D. Bingmann, University of Essen
M. Wiemann, University of Essen
F. Thévenod, University of Manchester
10:20 COFFEE BREAK CLINICAL AND DENTAL APPLICATIONS
10:40 – 13:00
Chairmen: T. Kerschbaum, J. Wissler 10:40
11:00
11:20
11:40
12:00
Biomaterials for Ossicular Chain Reconstruction
A New Stapes Prosthesis Made of Titanium for the Surgical Treatment of Otosclerosis
Long-term Evaluation of Osseointegrated Implants ad modum Brånemark: Review and Results of our Clinic
Improvement of Mechanical Properties of Self Setting Calcium Phosphate Bone Cements with Several Metal Oxides Transcortical Test-Cylinders Implanted in Femurs of the Göttinger Minipig and Their Upgrading for a Gap Healing Model
A. Neumann, University of Essen
P. Dost, University of Essen
T. Kerschbaum, University of Cologne
U. Gbureck, University of Würzburg
M. Schwarz, University of Mannheim
Biomaterials 2002: Fundamentals and Clinical Applications - 16 -
12:20
12:40
Modified Cemented Stem Fixation in Hip Arthroplasty with Computer Based Analysis
Different Surface Materials for Osseointegration of Hip Arthroplasties in a Canine Model
B. Barden, University of Essen
M. Oldenburg, University of Essen
13:00 LUNCH
CLINICAL APPLICATIONS 14:00 – 15:40
Chairmen: P. Guggenbichler, M. Haude 14:00
14:20
14:40
15:00
15:20
Knochenmineral aus dem Labor: Mechanisch Stabiler Knochenersatz
Experimental and Clinical Results of Material Modifications with Nanosilver for Prevention of Central Venous Catheter Related Infections
Percutaneous In-Situ Coronary Venous Arterialization (PICVA)
Improved Intracoronary Imaging Techniques: A Clinician’s Perspective
First Experience with Intracoronary Thermography
M. Epple, Ruhr- University of Bochum
P. Guggenbichler, University of Erlangen
M. Haude, University of Essen
C. von Birgelen, University of Essen
A. Schmermund, University of Essen
15:40 INVITATION TO THE SYMPOSIUM 2003 D. Bingmann FAREWELL H.P. Jennissen
Biomaterials 2002: Fundamentals and Clinical Applications - 17 -
Posters ID-Number 01 Engineering with Nitinol: Characterisation and Optimisation
D. Aslanidis @medical technologies n.v., Nitinol Engineering (B)
02 Structural Investigations of the Interaction of the Synthetic Peptide NK2 with Model Membranes R. Willumeit, H. Kamusewitz, M. Schossig, H. Clemens GKSS Forschungszentrum, WFS (D)
03 Incorporation of Two Different Meshes for Hernial Surgery - Immunohistochemical and Ultrastructural Results - I. Schmitz, D. Weyhe, V. Zumtobel, K.-M. Müller BG - Klinik Bergmannsheil, Pathologie (D)
04 Shear Strength of Experimental "Bone-Isoelastic" Titanium Alloys in the Ovine Femur A. Pingsmann, C. Wüllenweber, A. Piotrowski Universitätsklinikum Essen, Klinik und Poliklinik für Orthopädie (D)
05 Surface Modification of Fine and Ultrafine Particles Affects Their Ability to Cause Inflammation: Mechanisms of Action P. Borm, C. Albrecht, A. Becker, G. Cakmak, D. Höhr, T. Shi, A. Knaapen, R. Duffin, R. Schins Institut für Umweltmedizinische Forschung GmbH (IUF), Particle Research Core (D)
06 Characterization of MD05 - A Bone Substitute Device Having Osteoinductive and Osteoconductive Properties K. Hellerbrand, P. Happersberger, S. Wank, A. Stich, B. Krämer, S. Lang, S. Pöhling, A. Schütz, U. Kohnert Scil Biomedicals, Biotechnologie (D)
07 Porcine Heart Valve Interstitial Cells on Collagen Three-Dimensional Scaffolds: Characterization of Proteoglycans in the Newly Formed Extracellular Matrix P. Vischer, E. Schönherr, M. Rothenburger, W. Völker Institut für Arterioskleroseforschung, Zellbiologie und Ultrastrukturforschung (D)
08 Alumina Short Fibre Reinforced and Unreinforced Hydroxyapatite: Nano- and Microstructure A. Dorner-Reisel, V. Klemm, G. Irmer, E. Müller Freiberg University of Mining and Technology, Institute of Ceramic Materials (D)
09 First Analysis of Explanted Silicone Breast Implants A. Klocke, D. von Heimburg, N. Pallua, B. Glasmacher RWTH Aachen, Institut für Biomedizinische Technologien, Helmholtz-Institut, Kryobiologie & Biomaterialien (D)
Biomaterials 2002: Fundamentals and Clinical Applications - 18 -
ID-Number 10 Coating of Porous Bone Substitutes and of Metallic Prostheses
with PALASEPT K.-D. Kühn, U. Gopp, S. Vogt, M. Schnabelrauch Heraeus Kulzer GmbH & Co. KG, Bereich Medizin (D)
11 Modification of Surfaces to Control Protein Adsorption and Cell Growth M. Müller, D. Hegemann, M. Müller, V. Sciarratta, C. Hoffmann, H. Brunner, C. Oehr Fraunhofer IGB, Grenzflächentechnologie und Materialwissenschaft (D)
12 A Novel Type of Mechano-Protein with Promising Properties for Nanoscale Engineering G. Noll, M. Knoblauch, D. Prüfer, A. van Bel, W. Peters J.W.Goethe-Universität, AK Kinematische Zellforschung (D)
13 Tissue Engineering on Natural, Biomaterial and Polymer Surfaces Adjusted to Laminar and Defined Gradient Hydrodynamics J. Wissler ARCONS Applied Research (D)
14 Therapy and Prophylaxis of Adhesion After Traumatic Right-sided Rupture of the Diaphragm - A Case Report Th. Porté, S. Strametz, C. Grimme, I. Burkard, Ch. Jürgens Berufsgenossenschaftliches Unfallkrankenhaus Hamburg (D)
15 Therapy and Prophylaxis of Periarticular Ossifications After Long-Term Ventilation - A Case Report Th. Porté, S. Strametz, C. Grimme, I. Burkard, Ch. Jürgens Berufsgenossenschaftliches Unfallkrankenhaus Hamburg (D)
16 Reducing Adhesions in Experimental Animal Trials by an Antiadhesion - Foil - A Review Th. Porté, S. Strametz, C. Grimme, I. Burkard, Ch. Jürgens Berufsgenossenschaftliches Unfallkrankenhaus Hamburg (D)
17 Tissue Reaction of Coronary Arteries after Implantation of Coated Stents with Inti-Inflammatory and Anti-Proliferative Drug Release I. Karoussos, H. Wieneke, O. Dirsch, Y. Ji, Y. Gu, U. Dahmen, R. ErbelUniversitätsklinikum Essen, Klinik für Kardiologie (D)
19 Importance on In-Vitro Biocompatibility Investigations by Nanocolloids from Metallic Wear in Implant Materials L.E. Podleska, G. Taeger, B. Schmidt, I. Tikhovski, A. Fischer, S. Ruchholtz Universitätsklinikum Essen, Klinik und Poliklinik für Unfallchirurgie (D)
20 Experimental Studies on the Interface Ingrowth Characteristics of Hydroxyapatite Coated Lumbar Intervertebral Implants Y.T. Chen, S.L. Liu, I. Michiels Universitätsklinikum Essen, Klinik und Poliklinik für Orthopädie (D)
Biomaterials 2002: Fundamentals and Clinical Applications - 19 -
ID-Number 21 Nickel-Specific Cytokine Production in Allergic Versus Non-
Allergic Probands M. Lindemann, J. Böhmer, M. Zabel, H. Grosse-Wilde Universitätsklinikum Essen, Institut für Immunologie (D)
22 Corrosion of Chemically Structured Metallic Surfaces A. Runiewicz, A. Fischer Universität Essen, Werkstofftechnik (D)
23 Interaction of Natural and Synthetic Solutions with Concrete Materials J. Krylova, M. Sulkowski, A.V. Hirner Universität Essen, Institut für Umweltanalytik, Fachbereich Chemie (D)
24 Molecular Modelling Studies of the Interactions between Dystrophin and Beta-Dystroglycan M. Leis, H. Kuhn, M. Laub, H.P. Jennissen Universität Essen, Physikalische Chemie (D)
25 Electrochemical Studies of the Adsorption of Proteins on Conducting Surfaces K. Gloddek, U. Simon RWTH Aachen, IAC (D)
26 A Laser Direct Writing Technique for Patterning of Organic Monolayers - A Fascinating Approach to New Biosensors ?! Th. Balgar, R. Bautista, N. Hartmann, E. Hasselbrink Universität Essen, Physikalische Chemie (D)
27 Frost Dilatation and Pore System of Hardened Cement Paste under Different Storage Conditions A. Liebrecht, M.J. Setzer Universität Essen, IBPM - Institute of Building Physics and Materials Science (D)
28 Cytokine Expression of Human Donor Macrophages and Human THP-1 Leukaemia Macrophages after Challenge with Titanium Particles: Pharmacological Modulations M. Vendel, C. Reiser, Y. Ding, B. Barden, S. Frede, F. Löer, J. Fandrey Universitätsklinikum Essen, Orthopädische Klinik und Poliklinik der Universität Essen (D)
29 Systemic Distribution of Cobalt and Chromium in Patients with Well Fixed and Loose Arthroplasties N. Stais, B. Barden, M. Sulkowski, F. Löer, A. Hirner Universitätsklinikum Essen, Klinik und Poliklinik für Orthopädie (D)
30 Langmuir-Blodgett Films of Nanosized Au55-Cluster A. Vassiliev, H. Rehage, G. Schmid Universität Essen, Institut für Physikalische Chemie (D)
31 Thin Films of BaTiO3 Prepared by R.F. Magnetron Sputtering K.V. Reddy, Z. Qiao, D. Mergel Universität Essen, Physics Department WG Thin Film Technology (D)
Biomaterials 2002: Fundamentals and Clinical Applications - 20 -
ID-Number 32 Correlation of Particle Fluxes and Film Properties of Hard Carbon
Coatings O. Filipov Universität Essen, Technische Physik (D)
33 The Immobilization of rhBMP-2 on Metals by Adsorption M. Chatzinikolaidou, H.P. Jennissen Universitätsklinikum Essen, Institut für Physiolog. Chemie/ Abtlg. Biochemische Endokrinologie (D)
34 Biocompatibility of a Nickel-Free Steel (P2000) Assayed with Direct Metal Contact of Osteoblast-Like Cells M. Mölders Universität Essen, Institut für Physiologie (D)
35 3D-Reconstruction of Confocal Image Stacks: Visualisation of Live Cells in Bone A. Roth, K. Melzer, K. Annacker (D)