biomaterials for lower-limb bone repairibruce/courses/ee3ba3_2012/...bone is the ideal material...
TRANSCRIPT
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Biomaterials for Lower-Limb Bone Repair
Matt Stone Nurul Matkamil
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Outline:
Introduction a. Bone structure and properties b. Ideal criteria for biomaterials used in bone repair History and examples of biomaterials: a. Grafts b. Metal c. Ceramics d. Polymer Future outlook Conclusion
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Bone structure and properties
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Key Terms Osteoconductivity
Osteoinductivity
Osteogenicity
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History
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History
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Challenges
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Grafts
Allograft Graft from donor of the
same species
Autograft Graft taken from the
patient’s own body
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Grafts
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Grafts
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Metals Internal fixation
Partial arthroplasty of the knee, hip, or ankle
Total arthroplasty of the knee, or hip
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Metals
Stainless steel Older uses
Co-Cr alloys Current staple
Titanium alloys Newer and promising
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Metals
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Metals
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Metals
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Ceramics
• Alumina • Bioglass • Hydroxyapatite
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Alumina
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Alumina
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Bioglass
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Hydroxyapatite (HA)
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Hydroxyapatite (HA)
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Polymers
PMMA Bone cement
High density polyethylene Low friction interface
Hydrogel Scaffolding
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Polymers
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Polymers
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Polymers
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Composites and Others
Metal coated with hydroxyapatite
Polymer-ceramics: collagen and hydroxyapatite
Inject bone marrow, growth factors, and bone morphogenic protein
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Future Outlook
Nanoengineering biocompatible surfaces for adhesion of osteogenic entities
Carbon nanotube re-enforcement
Tissue engineering
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Future Outlook
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Summary
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Conclusion
Bone is the ideal material
Current methods for procuring bone still have challenges
Metal is the mainstay of lower-limb reconstruction
Combinations of materials work even better
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Yuan, Huiping et al. (2010, March). “Osteoinductive ceramics as a synthetic alternative to autologous bone grafting”. Proceedings of the National Academy of Sciences. Aug 3, 2010. Vol 107. No 31. Available: http://www.pnas.org/content/107/31/13614 [Sep 20, 2012].
Gyger, L. S. et al. "Porous Gelcast Ceramics for Bone Repair Implants." Internet: http://www.bioinspired.umd.edu/files/SEM_05_gelcast.pdf [Sep 25, 2012]
Morais JM et al. (Feb 9, 2010). “Biomaterials/Tissue Interactions: Possible Solutions to Overcome Foreign Body Response” American Association of Pharmaceutical Scientists Journal. Jun 2010. Vol 12. No. 2. Available: http://www.ncbi.nlm.nih.gov/pubmed/20143194 [Sep 21, 2012].
Hench, Larry L. and Thompson, Ian. (2010, May 19). “Twenty-first century challenges for Biomaterials”. Journal of The Royal Society: Interface Focus. Available: http://rsif.royalsocietypublishing.org/content/early/2010/05/18/rsif.2010.0151.focus [Sep 23, 2012]
Cunniffe Gm et al. (Aug 1, 2010) “Development and characterisation a collagen nano-hydroxyapatite composite scaffold for bone tissue engineering.” Journal of Materials Science: Materials in Medicine. Available: http://www.ncbi.nlm.nih.gov/pubmed/20091099 [Sep 22, 2012]
Ficai, Anton et al. (2011) “Advances in Collagen/Hydroxyapatite Composite Materials”. InTech. Available: http://www.intechopen.com/books/advances-in-composite-materials-for-medicine-and-nanotechnology/advances-in-collagen-hydroxyapatite-composite-materials [Sep 22, 2012]
Wahl DA and Czernuszka JT (2006) “Collagen-Hydroxyapatite Composites For Hard Tissue Repair” European Cells and Materials Vol 11 2006. pg 43-56. Available: http://www.ncbi.nlm.nih.gov/pubmed/16568401 [Sep 21 2012]
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http://www.pnas.org/content/107/31/13614http://www.bioinspired.umd.edu/files/SEM_05_gelcast.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/20143194http://www.ncbi.nlm.nih.gov/pubmed/20143194http://rsif.royalsocietypublishing.org/content/early/2010/05/18/rsif.2010.0151.focushttp://www.ncbi.nlm.nih.gov/pubmed/20091099http://www.intechopen.com/books/advances-in-composite-materials-for-medicine-and-nanotechnology/advances-in-collagen-hydroxyapatite-composite-materialshttp://www.intechopen.com/books/advances-in-composite-materials-for-medicine-and-nanotechnology/advances-in-collagen-hydroxyapatite-composite-materialshttp://www.ncbi.nlm.nih.gov/pubmed/16568401
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References do Nascimento, Cassio et al. (2007)“Biomaterials Applied to the Bone Healing Process” International Journal
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Martin, RB et al. (April 13, 1993) “Bone ingrowth and mechanical properties of coralline hydroxyapatite 1 yr after implantation”. Biomaterials. Vol. 14 Issue 5. Available: http://www.sciencedirect.com/science/article/pii/0142961293900524 [Sep 24 2012]
Cristofolini, Luca et al. (2010) “Structural behaviour and strain distribution of the long bones of the human lower limbs” Journal of Biomechanics. Available: http://www.ncbi.nlm.nih.gov/pubmed/20031136 [Sep 25 2012]
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http://www.scielo.cl/scielo.php?pid=S0717-95022007000400025&script=sci_arttexthttp://www.tissueeng.net/lab/papers/hydrogels in regenerative medicine.pdfhttp://www.pnas.org/content/early/2012/02/29/1201122109http://www.sciencedirect.com/science/article/pii/S1748013208000182http://www.sciencedirect.com/science/article/pii/S1748013208000182http://www.ncbi.nlm.nih.gov/pubmed/21129153http://www.sciencedirect.com/science/article/pii/0142961293900524http://www.ncbi.nlm.nih.gov/pubmed/20031136
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References Asmani M. et al (2001) “Influence of Porosity on Young’s Modulus and Poisson’s Ratio in alumina ceramics.”
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Brydone AS et al. (2010)“Bone grafting, orthopaedic biomaterials, and the clinical need for bone engineering” Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. Available: http://www.ncbi.nlm.nih.gov/pubmed/21287823 [Sep 19 2012]
Stocker, Steven and Wolinetz, Carrie D. (2009)“Bone Builders: The Science of Grafts, Biomaterials, and Bone Engineering” Breakthroughs in Bioscience. Available: http://www.faseb.org/LinkClick.aspx?fileticket=whm%2Fgm9ClxU%3D&tabid=366 [Sep 19 2012]
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Enderle John et al. Introduction to Biomedical Engineering. USA: Elsevier Academic Press. 2005. pp 255-301
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References Matsumine A. et al. (Jul 2004). “Calcium hydroxyapatite ceramic implants inbone tumour surgery” The
Journal of Bone and Joint Surgery. Available: http://www.ncbi.nlm.nih.gov/pubmed/15274270 [Sep 25 2012]
Magdeski, J.S. (May 12, 2010). “The Porosity Dependence Of Mechanical Properties Of Sintered Alumina”. Journal of the University of Chemical Technology and Metallurgy. Available: http://www.uctm.edu/journal/j2010-2/5_Magdeski_143-148.pdf [Sep 26 2012]
Hing, Karin A.(Dec 14, 2004) “Bone Repair in the Twenty-First Century: Biology, Chemistry or Engineering?” The Royal Society. Available: http://rsta.royalsocietypublishing.org/content/362/1825/2821.full.pdf [Sep 24 2012]
Kanaya, F., Maehara, H. and Tanaka, K. (Mar 2012) “Vascularized fibular graft for bone defects after wide resection of musculoskeletal tumors”. Journal of Orthopaedic Science. Available: http://www.springerlink.com/content/m057854446787220/ [Sept 20 2012]
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Hoffman, A. S. et al. “Classes of Materials Used in Medicine” in Biomaterials Science: An Introduction to Materials in Medicine, 2nd ed. San Diego: Elsevier Inc., 2004
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http://www.ncbi.nlm.nih.gov/pubmed/15274270http://www.uctm.edu/journal/j2010-2/5_Magdeski_143-148.pdfhttp://www.uctm.edu/journal/j2010-2/5_Magdeski_143-148.pdfhttp://rsta.royalsocietypublishing.org/content/362/1825/2821.full.pdfhttp://www.springerlink.com/content/m057854446787220/http://onlinelibrary.wiley.com/doi/10.1002/jor.1100180314/abstracthttp://www.springerlink.com/content/x1272w73843hu546/
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References de Boer, H.H. (Jan 1988) “The History of Bone Grafts”. Clinical Orthopaedics and Related Research. Available:
LibAccess McMaster [Sept 22 2012]
Rowe, D. et al. (2010) “History of lower limb reconstruction after trauma”. ANZ Journal of Surgery. Available: http://onlinelibrary.wiley.com/doi/10.1111/j.1445-2197.2012.06271.x/pdf [Sept 22 2012]
Furnival, T., and McCloskey, C. “Structure of bone and implant materials”. Internet: http://www.doitpoms.ac.uk/tlplib/bones/printall.php, Aug 2011 [Sept 25 2012].
Li, M. et al. (2008) “Preparation, microstructure and mechanical properties of porous titanium sintered by Ti fibres”. Journal of Materials Science: Materials in Medicine. Available: http://www.springerlink.com/content/p7l1408648p21w54/ [Sept 20 2012]
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http://onlinelibrary.wiley.com/doi/10.1111/j.1445-2197.2012.06271.x/pdfhttp://www.doitpoms.ac.uk/tlplib/bones/printall.phphttp://www.springerlink.com/content/p7l1408648p21w54/
Biomaterials for Lower-Limb Bone RepairOutline:Bone structure and propertiesKey TermsHistoryHistoryChallengesGraftsGraftsGraftsMetalsMetalsMetalsMetalsMetalsCeramicsAluminaAluminaBioglassHydroxyapatite (HA)Hydroxyapatite (HA)PolymersPolymersPolymersPolymersComposites and OthersFuture OutlookFuture OutlookSummaryConclusionSlide Number 31ReferencesReferencesReferencesReferences