BIOMANUFACTURING

World-class t raining programs

Top-ranked biotechnology industry

Ideal climate for business and life

BIOMANUFACTURING

IN NORTH CAROLINA

Companies invest hundreds of millions of dollars in biomanufacturing plants, which require physical infrastructure as well as human resources for support. North Carolina meets those needs with a unique combination of assets: a skilled workforce, a top-ranked biotech industry, a low cost of doing business and a high quality of life.

The state ranks highly in external surveys as well.

Site Selection• magazinerecognizedNorthCarolina’sbusinessclimateasbest in the countryforsixofthelastsevenyears,including2007.

ErnstandYoung’sannual•Beyond Bordersreportputsthestateconsistentlyonthelistoftop states for biotechnology.

IntheMilkenInstitute’s•cost-of-doing-businessindex,North Carolina’s costs are far less thanotherleadingstatesforbiotechnology.

SevenscientistswithtiestoNorthCarolinahavebeen•honoredwithNobel Prizes.

Some of the world’s largest pharmaceutical companies make their products in North Carolina. Novartis Vaccines and Diagnostics recognized the state’s advantages and chose Holly Springs over several other locations for a $267 million plant to produce flu vaccine. Merck, looking for a place to produce vaccines for measles, mumps, rubella, chicken pox and shingles, built a $300 million facility in Durham. Both companies have since announced growth plans and additional jobs at these plants.

Novo Nordisk Pharmaceutical Industries and United Therapeutics, two companies with a long-term North Carolina presence, are also expanding their

efforts in the state. Pfizer Poultry Health purchased North Carolina-

based Embrex and now operates a poultry vaccine plant near Laurinburg. GlaxoSmithKline, Diosynth and many other multinational companies operate facilities in North Carolina. Some are among the largest of their type in the world, including Wyeth, Talecris, Biogen Idec and Novozymes.

To add to this impressive roster, the Biotechnology Center is growing new companies from university research in plant science, vaccines and other technologies. The Biotechnology Center is also working with the Department of Commerce and statewide partners to bring in new biomanufacturing operations as well as to expand existing ones.

These companies, plus those offering development, analytical, production and engineering services have created a community that ranks among the best locations for biomanufacturing in the world.

A Home for BiomAnufActuring

“North Carolina’s business climate, low tax burden and high-skill workforce make this region an attractive place for industries like biotechnology and biomanufacturing.”—NorTH CarolINa GoVErNor MIKE EaSlEy

“We appreciate the support we have received from state and local officials and the Durham community since we located here four years ago. We are proud to be a part of North Carolina’s expanding biopharma sector.”

—JoHN WaGNEr, MaNaGEr of MErCK’S DUrHaM PlaNT

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A L A M A N C EA L E X A N D E R

A L L E G H A N Y

A N S O N

A S H E

AV E RY

B E A U F O R T

B E R T I E

B L A D E N

B R U N S W I C K

B U N C O M B E

B U R K E

C A B A R R U S

C A L D W E L L

CAMDEN

C A R T E R E T

C A S W E L L

C ATAW B AC H AT H A M

C H E R O K E E

CHOWAN

C L AY

C L E V E L A N D

C O LU M B U S

C R AV E N

C U M B E R L A N D

CURR I TUCK

D A R E

D AV I D S O N

D AV I E

D U P L I N

D U R H A M

E D G E C O M B E

F O R S Y T H

F R A N K L I N

G A S TO N

G AT E S

G R A H A M

G R A N V I L L E

G R E E N E

G U I L F O R D

H A L I FA X

H A R N E T T

H AY W O O D

H E N D E R S O N

H E R T F O R D

H O K E

H Y D E

I R E D E L L

J A C K S O N

J O H N S TO N

J O N E S

L E E

L E N O I R

L I N C O L N

M C D O W E L L

M A C O N

M A D I S O N

M A R T I N

M E C K L E N B U R G

M I TC H E L L

M O N TG O M E RYM O O R E

N A S H

N E W H A N O V E R

N O R T H A M P TO N

O N S LO W

O R A N G E

PA M L I C O

PASQUOTANK

P E N D E R

PERQU IMANS

P E R S O N

P I T T

P O L K

R A N D O L P H

R I C H M O N D

R O B E S O N

R O C K I N G H A M

R O WA N

R U T H E R F O R D

S A M P S O N

S C OT L A N D

S TA N LY

S TO K E S

S U R RY

S WA I N

T R A N S Y LVA N I A

T Y R R E L L

U N I O N

VA N C E

WA K E

WA R R E N

WA S H I N G TO N

WATA U G A

WAY N E

W I L K E S

W I L S O N

YA D K I N

YA N C E Y

Southport

Wilmington

Maxton

Fayetteville

Pisgah Forest

Marion

Brevard

Boone

Lenoir

Lincolnton

Huntersville

Landis

Charlotte

Burlington

WhitsettGreensboro

High Point

Franklinton

Holly Springs

PittsboroMorrisville

Clayton

RTP

Zebulon

Sanford

Durham

Raleigh

Rocky Mount

Farmville

Greenville

Wilson

Pharmaceutical Service Providers

Biomanufacturers

Manufacturers of Traditional Pharmaceuticals and Diagnostics

Manufacturers of traditional PharMaceuticals and diagnostics

c o m pa n y l o c at i o n p r o d u c t s

Actavis U.S. LincolntonOintments, creams, nasal sprays and other products

Banner High Point Pharmaceutical gel caps

BASF Corp. Wilmington Vitamins and nutrition products

Baxter Healthcare Marion Intravenous solutions

BD Diagnostics, TriPath Burlington Cervical cancer screening kits

bioMerieux Durham Diagnostic kits

Carolina Medical Products Farmville Ointments, powders, non-injectable solutions

Covidien Mallinckrodt Raleigh Acetaminophen

Eisai RTP Alzheimer’s drug

GBF Medical Group Greensboro Diagnostic kits

GlaxoSmithKline Zebulon Drug formulation and packaging

Hospira Rocky Mount Injectable solutions and drugs

MEDTOX Diagnostics Burlington Drug testing kits

Merck & Company Wilson Pharmaceuticals

Microban International Huntersville Antimicrobial polymeric additives

Nitta Gelatin USA Fayetteville Gelatin powder for pharmaceuticals and food

Novo Nordisk Pharmaceutical Industries Clayton Human insulin formulation and sterile filling

Purdue Pharmaceuticals LP Wilson Pain relief and asthma drugs

Qualicaps Whitsett Pharmaceutical gel caps

Sandoz Wilson Oral-dosage pharmaceuticals

United Therapeutics RTPCardiovascular, cancer and infectious disease treatments

Vintage Pharmaceuticals Charlotte Pharmaceuticals

BioManufacturers

c o m pa n y l o c at i o n p r o d u c t s

Ajinomoto USA Raleigh Amino Acids

Alphavax Durham Vaccines

Archer Daniels Midland Southport Citric acid

Argos Therapeutics Durham Vaccines

Biogen Idec RTPMultiple sclerosis, psoriasis and Crohn’s disease treatments

Biolex Therapeutics Pittsboro Therapeutic proteins

Catalent Pharma Solutions RaleighDevelopment, manufacture and packaging services for bio-based products

CellzDirect RTP Specialized cells and their products.

Diosynth Biotechnology RTP Contract biopharmaceutical manufacturing

Greer Laboratories Lenoir Allergenic extracts, vaccines

KBI BioPharma Durham Contract biopharmaceutical manufacturing

Merck & Company Durham Vaccines

Molecular Toxicology BooneResearch and testing products; contract manufacturing

Novartis Vaccines and Diagnostics Holly Springs Vaccines

Novozymes North America Franklinton Industrial enzymes

Pfizer Poultry Health Maxton Poultry vaccines

Talecris Biotherapeutics Clayton Blood and plasma-related therapeutics

Wyeth Pharmaceuticals Sanford Vaccines

Biomanufacturing is a clean manufacturing process that uses living cells as miniature factories. It’s how a child’s measles vaccine and the

supplement in an athlete’s protein shake are produced.

Making these and other products through both biomanu-facturing and traditional processes creates jobs, con-

tributes to the state’s economy, and improves lives here and around the globe. Approximately 18,000 North Carolina residents are employed by a broad range of companies including biomanufacturers, manufacturers of traditional pharmaceuticals and

diagnostics, as well as pharmaceutical service pro-viders, which offer analytical and production services.

(tables below, right)

Although they won’t replace all of the lost furniture and textile manu-facturing jobs, these companies offer higher-paying jobs than traditional manufacturing:

Entry-level technicians typically earn $25,000 to $30,000 with basic •training and often earn more than $50,000 after five years of experience.

The average salary for all jobs in the pharmaceutical manufactur-•ing industry—including those requiring more education—exceeds $82,000 in the state.

Also, biomanufacturing plants are located around the state, which distrib-utes these jobs throughout North Carolina.

Wherever the location or whatever the product, biomanufacturing plants are complex operations that typically run 24 hours a day,

seven days a week, under stringent regulation by the U.S. Food and Drug Administration. Biomanufacturing companies require trained technicians to operate these plants efficiently and in compliance with FDA rules.

The NCBioImpact partnership was formed to meet those rigorous demands. North Carolina’s universities and community col-

leges collaborated with industry, the North Carolina Biosciences Organization and the Biotechnology

Center to produce and deliver workforce-train-ing programs across the state. The Golden LEAF Foundation has committed nearly $70 million of North Carolina’s tobacco-settlement money to sup-

port this initiative. Industry partners have allocated millions of dollars of in-kind services and equipment.

And the state’s General Assembly supplies ongoing fund-ing for operations.

This broad partnership has yielded a three-pronged approach:

The Golden LEAF • Biomanufacturing Training and Education Center on Centennial Campus at North Carolina State University. BTEC is the world’s largest hands-on training location dedicated to learning the ins and outs of biomanufacturing. (www.btec.ncsu.edu)

The • Biomanufacturing Research Institute and Technology Enterprise at North Carolina Central University. BRITE is dedicated to research and higher-level training in the life sciences, and to also uncovering ways to improve biomanufacturing processes. (brite.nccu.edu)

NCBioNetwork• is a collection of more than 20 community colleges across the state connected by their biotechnology program offerings. The effort includes seven specialized centers that meet specific needs of life-science industry sectors. (www.ncbionetwork.org)

From certificate to Ph.D., NCBioImpact trains and helps retain job-ready employees at all levels. This comprehensive strategy creates a continuum of education in scientific, technical and engineering disciplines. (www.ncbioimpact.com)

PharMaceutical service Providers

c o m pa n y l o c at i o n p r o d u c t s

aaiPharma Wilmington Analytical and manufacturing services

Catalent Pharma Solutions Morrisville Analytical services

DSM Pharmaceuticals GreenvilleBulk chemical synthesis, fill and finish, aseptic filling services

Gorbec Pharmaceutical Services Durham Contract analysis and production services

Harmony Labs LandisDevelopment and manufacture of topical pharmaceuticals and cosmeceuticals

Hospira ClaytonSterile solutions and emulsions for infusion and nutrition therapy

Laboratory Corporation of America Burlington, RTP Clinical laboratory services

Metrics Greenville Analytical services

PharmAgra Labs Brevard Custom organic compounds

PharmaCore High Point Organic chemical synthesis

Pisgah Labs Pisgah Forest Organic chemical synthesis

JoBs for north carolina

Manufacturing locations

high-Quality Workforce

“North Carolina understands the bioscience manufacturing sector needs an abundant supply of specially trained workers, so we work hard to develop a job-ready workforce that can help make businesses more productive and profitable.”

—Norris TolsoN, PresideNT aNd Ceo, NorTh CaroliNa BioTeChNology CeNTer

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15 T.W. AlexAnder drive • P.O. BOx 13547 • reseArch TriAngle PArk, nc 27709-3547 919-541-9366 • fax 919-990-9544 web WWW.ncBiOTech.Org email infO@ncBiOTech.Org

With offices in Asheville • chArlOTTe • greenville • WilmingTOn • WinsTOn-sAlem

North Carolina’s thriving biotechnology industry, top-notch science, unbeatable climate for business and great quality of life create the ideal place for a biomanufacturing facility.

The state ups the ante with a workforce-development system that is second to none and the largest dedicated training facility in the world for biomanufacturing. In fact, the Milken Institute’s Biotech Index report has ranked the Research Triangle area No. 1 in human capital and biotechnology workforce.

Supporting that community are a number of architecture, construction, engineering, instrumentation and consulting firms that design, build and validate bioprocessing plants in compliance with FDA requirements.

Rounding out the mix are the state affiliate of BIO, chapters of ISPE, PDA and ASQ, plus the

Biotechnology Center’s Bioprocessing and Process Development Group, where process-development scientists and engineers discuss issues, challenges and developments in biomanufacturing.

Find out what makes North Carolina like nowhere else in the world for biomanufacturing. Contact Bill Bullock at 919-541-9366 or bill_bullock@ncbiotech.org.

A Community Like nowhere eLse in the worLd