Biological Pathways

Interlocutors

Sheldon Cohen, Jill Cyranowski, Pete Gianaros, Joel Greenhouse, Anna Marsland

What we do now…

Cardiovascular psychophysiology— Sympathetic/parasympathetic

Neuroendocrine—Cortisol, catecholamines, oxytocin

Neuroimmune

Brain imaging

In settings of:

Ambulatory and Lab

Netter (1962) CIBA collection of Medical Illustrations. Pp 164-165

Response Systems..

What measures should we use in the future?

Illustrate an approach to this question--- for critique by the interlocuters and all of you

Measure MusingsHow should we approach the literature?

Last month’s encounters.

Questions:

Is it a Mind measure?

Is it a Body/Disease measure?

Is it a Mind<>Body measure?

Is it feasible in human research lab, in epidemiology?

Does it link us to new development in bench science? Genetics?

• Stress on reproductive hormones—Allopregnanolone

• Vascular stiffness from ambulatory recording

• Microparticles and atherosclerosis

• Endoplasmic reticulum and stress

Four Recent Candidates for evaluation

Girdler et al. Psychophysiology (2006)

Score:

Mind 1 (responds to stress)

Body/Disease .5

Mind<>Body 1

Feasibility 1

Innovative 0

Comment: nice to explore ethinic differences.

Dolan et al. HYPERTENSION, 2006

Score:

Mind .5

Body/Disease 1

Mind<>Body .5

Feasibility 1

Innovative .5 (novel but not bench)

Comment: Useful with archival data

Boulanger,et al., HYPERTENSION, AUG 2006

Score:

Mind .75

Body/Disease 1 (complex)

Mind<>Body .75

Feasibility .5

Innovative 1

Comment: Promising, might wait for more development.

Marx, SCIENCE, 15 SEPT 2005

Score:

Mind .25 (responds to stress)

Body/Disease 1

Mind<>Body .25

Feasibility .25

Innovative 1

Comment: Cell stress/can’t connect.

Measurement models—time permitting