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BIO – DATA 1. Name and full correspondence address:
Name: Dr. Srinivas Kantevari
Designation: Senior Scientist
Address: Crop Protection Chemicals Division (Organic Chemistry
Division–II) CSIR–Indian Institute of Chemical Technology, Hyderabad–500 007, INDIA
2. Email and contact number:
3. Institution: CSIR-Indian Institute of Chemical Technology, CSIR,
Hyderabad
4. Date of Birth: 05 May 1969
5. Gender (M/F): M
6. Category (Gen/SC/ST/OBC): OBC
7. Whether differently abled (Yes/No): No
8. Academic Qualification (Undergraduate Onwards)
S. No.
Degree Year Subject University/ Institution % of marks
1 B.Sc. 1989 Chemistry Andhra Loyala College, Vijayawada, Nagarjuna University, Guntur, A.P.
78
2 M.Sc. 1991 Applied Chemistry Department of Chemistry, NIT, Warangal, A.P. 75
3 Ph.D 1996 Organic Chemistry Department of Chemistry, IIT Delhi, New Delhi
4 Post Doctoral
2001-2003
Organic Chemistry Drexel University College of Medicine and Univ. of Pensulvania, Philadelphia, USA
9. Ph.D Thesis title: Synthesis of new calix(n)arenes for ionic and molecular recognition. Supervisor: Prof. H.M. Chawla, Department of Chemistry, IIT Delhi.
10. Work experience (in chronological order)
Sl No. Institution Place Position From (Date) To (date) 1. CSIR-IICT, Hyderabad Principal Scientist 01.04.2012 Till date 2. CSIR-IICT, Hyderabad Senior Scientist 01.04.2008 31.03.2012 3. CSIR-IICT, Hyderabad Scientist C
(NIH research Fellow) 13.02.2001 31.03.2008
4. Drexel University College of Medicine/ Mount Sinai Medical School, New York, USA
Research Scientist (NIH research Fellow)
Dec 2006 Oct 2008
5 Drexel University College of Medicine Philadelphia, USA
Post Doctoral Fellow July 2001 June 2003
6. CSIR – IICT, Hyderabad Scientist B 13 March, 1997 12 Feb. 2001
7. National Institute of Immunology, New Delhi
Research Associate June, 1995 10 March, 1997
8. Department of Chemistry, IIT Delhi, New Delhi
Research Associate Oct ,1995 May, 1996
Ongoing Projects / Funding
DBT- project (26thDec,2013-Dec 2016)
Novel immunomodulatory agents for type II diabetes through targeting the NLRP3 inflammasome signalling cascade Indo-Australian Biotechnology Fund 2012-13. Budget: Rs. 96.45 Lakhs. (Role: PI and Coordinator from Indian side)
DBT- project (2013-16)
”Identification of the early diagnostic biomarkers and effective small molecules for the therapy of retinoblastoma eye tumour: A Functional proteomics approach." DBT-BIOCARE project (other PI: Dr. Anjana Devi, Chemical Biology)-2013. IICT Budget: Rs 15,20,000.00.
Sponsored / Consultancy NCEs for Pesticide activity (Sponsored by Hyderabad Chemicals Pvt. Ltd.) Rs. 7.65 Lakhs
CSIR-12th FYP Projects
(2012-17)
1) Organic Reactions in Generating Innovative & Natural Scaffolds (CSC0108-ORIGIN ) (Role: Activity Leader)
2) Development of Novel Vaccine Adjuvants (CSC0205 – DENOVA) (Role: Activity Leader)
3) Intelligent Coatings (INTELCOAT) (Role: Activity Leader)
4) TAPSUN ( NWP-0054) (Role: Activity Leader)
5) OLED (NWP-0055) (Role: Activity Leader)
ICMR Project
“In vitro and in vivo evaluation of synergistic effect of novel microtubule-interfering agent amino-noscapine and taxotere for prostate cancer therapy” ICMR approved project (Ref No. 5/13/186/2012-NCD III) IICT Budget: Rs. 22,00,000 (Waiting Sanction orders)-2015.(Other PI: Dr. Usha Agrawal, NIP, New Delhi)
Sponsored projects (Completed)
1. New chemical entities screening for agrochemical use (Hyderabad Chemicals, Hyderabad).
2. Process for the preparation of LOSARTAN-K, an angiotensin receptor antagonist (Cadila Pharmaceuticals, Gujarat)
3. Synthesis of isoquinoline alkaloid R-S NOSCAPINE ( INGA Pharmaceuticals, Mumbai) 4. Value added products from n-butylbenzene (Vinati Organics Ltd., Mumbai) 5. Cost-effective process for the conversion of 3-cyanopyridine to 2-chloro nicotinic acid
(Jubilant Organics Ltd., Delhi) 6. Synthesis of INDOXACARB, A Neonicotinoid insecticide (Consortium of PMA)
11. Professional Recognition/ Award/ Prize/ Certificate, Fellowship received:
7. Preparation of Inkjet dyes & other specialty chemicals (Vasant Chemicals) 8. New molecules for pesticide activity (NIMITLI Programme, CSIR) 9. New chemical entities screening for agrochemical use (DuPont) 10 Custom synthesis of speciality chemicals (Anu Laboratories, Hyderabad) 11 Preparation of n-butyl acrylate and 2-ethylhexylacrylate (Andhra Petrochemicals, A.P)
Research Activities
1 Design, synthesis and evaluation of novel antitubercular agents 2 Dual inhibitors for cardiovascular diseases. 3 Inhibitors targeting NLRP3 inflammasome cascade for treating Type 2 Diabetes 4 Development of new photolabile compounds to control cellular chemistry and physiology
using photo release technology
5 Development of imaging agents for probing Alzheimer’s Disease (AD) 6 Receptor targeted approaches for the development of new chemical entities
i) New molecules as Ryanodine receptor activators
ii) Structure-activity relationship of Oxadiazine compounds with voltage gated sodium channels for agrochemical use
7. Synthesis of novel calix-pyrroles and calix-benzodipyrroles for ionic and molecular recognition in solution and gas phase
8. Logic-based Single Reactant Replacement (SRR) approaches for multi-component reactions (MCRs)
9. Dendrimer chemistry 10. Organic reactions and Heterocyclic chemistry
1. ACS Reviewer appreciation award 2011 2 Editorial Board Member-Merck Index Online-Royal Society of Chemistry, London. 2. NIH Research Fellowship 3. Advisory editorial board Member for i) Current Green Chemistry
ii) Open Journal of Catalysis
iii) Pathobiology and Toxicology
iv) Member, Editorial board of reviewers of ARKIVOC
v) Serving as Reviewer for Journal of Medicinal Chemistry, Journal of Organic Chemistry, Organic Letters, Current Medicinal Chemistry, Current Topics in Medicinal Chemistry, Drug Design, Discovery and Therapy, Organic and Biomolecular Chemistry, Synlett, Synthesis, Montasch Chemie, Canadian J Chemistry, Organo Metallic Chemistry, J. Applied catalysis, J. Molecular Catalysis A, Catalysis Communications.
4 Awarded Research Associate ship from Council of Scientific and Industrial Research (CSIR), New Delhi, INDIA.
5 Best Research Scholar award during the year 1995-96, IIT Delhi. 6 Senior Research Fellowship by Indian Institute of Technology, New Delhi August 1993
to December 1995). Junior Research Fellowship by Indian Institute of Technology, New Delhi (August 1991 to July 1993).
7 Member, American Chemical Society (ACS), USA
12. List of Publications:
78. Design, synthesis and evaluation of novel 2-butyl-4-chloroimidazole derived
peptidomimetics as Angiotensin Converting Enzyme (ACE) inhibitors
Anvesh Jallapally, Dinesh Addla, Pankaj Bagul, Balasubramanian Sridhar, Sanjay K.
Banerjee, Srinivas Kantevari*
Bioorganic & Medicinal Chemistry, 2015, 23(13) 3526-3533.
77. One-pot synthesis and UV-Visible absorption studies of novel tricyclic heterocycle
tethered Xanthene-1,8-diones
Yempala Thirumal, Kantevari Srinivas*
Journal of Chemical Sciences, 2015, 127 (5), 803-810.
76. Investigation of anion-pi interactions involving thiophene walls incorporated
calix[4]pyrroles
Chintapalli Dinesh Kumar, Katukuri Sirisha, Devendra Kumar Dhaked, Pulipati Lokesh,
Akella V. S. Sarma, Prasad V. Bharatam, Srinivas Kantevari, Prabhakar Sripadi.
J. Org. Chem. 2015, 80 (3), pp 1746–1753.
75. Design and synthesis of novel carbazole tethered pyrrole derivatives as potent
inhibitors of Mycobacterium tuberculosis
Goverdhan Surineni, Perumal Yogeeswari, Dharmarajan Sriram, Srinivas Kantevari*
Bioorg. Med. Chem. Lett., 2015, 25(3), 485-491.
74. Rational design, synthesis and evaluation of novel substituted 1, 2, 3-triazolyl methyl
carbazoles as potent inhibitors of mycobacterium tuberculosis.
Goverdhan Surineni, Perumal Yogeeswari, Dharmarajan Sriram, Srinivas Kantevari*
Med. Chem. Res., 2015, 24 (3), 1298-1309.
73. Rational design of biarylpharmacophore inserted noscapine derivatives as potent
tubulin binding anticancer agents.
Seneha Santoshi, Naresh Kumar Manchukonda, Charu Suri, Manya
Sharma, Balasubramanian Sridhar, Silja Joseph, Manu Lopus, Srinivas
Kantevari, Iswar Baitharu, Pradeep Kumar Naik.
J Comput Aided Mol Des. 2015, 29(3), 249-270.
72. Synthesis of novel l-rhamnose derived acyclic C-nucleosides with substituted 1,2,3-
triazole core as potent sodium-glucose co-transporter (SGLT) inhibitors.
Siddamal Reddy Putapatri, Abhinav Kanwal, Sanjay K. Banerjee, Srinivas Kantevari*
Bioorg. Med. Chem. Lett., 2014, 24(6), 1528-1531.
71. Evaluating the cation binding strength and selectivity of calix[4]pyrroles:a computational
and ESI-MS/MS study.
Chinthapalli Dinesh Kumar, Bhaskar Sharma, Yarasi Soujanya Vadla Naresh Chary,
Santhosh Reddy Patpi, Srinivas Kantevari, Garikapati Narahari Sastry and Sripadi
Prabhakar.
Phys.Chem. Chem. Phys. 2014, 16, 17266-17271.
70. Synthesis of L-Rhamnose derived chiral bicyclic triazoles as novel sodium-glucose
transporter (SGLT) inhibitor.
Siddamal Reddy Putapatri, Abhinav Kanwal, Sanjay K. Banerjee, Srinivas Kantevari*
Org.Biomol.Chem. 2014, 12, 8415-8421.
69. Synthesis and biological evaluation of novel biaryl type α-noscapine congeners.
Naresh Kumar Manchukonda, Pradeep Kumar Naik, Balasubramanian Sridhar,
Srinivas Kantevari*
Bioorg. Med. Chem. Lett., 2014, 24(24), 5752-5757.
68. 2-Butyl-4-chloroimidazole based substituted piperazine-thiosemicarbazone hybrids as
potent inhibitors of Mycobacterium tuberculosis.
Anvesh Jallapally, Dinesh Addla, Perumal Yogeeswari, Dharmarajan Sriram, Srinivas
Kantevari*
Bioorg. Med. Chem. Lett., 2014, 24(23), 5520–5524.
67. Design and green synthesis of 2-(diarylalkyl)aminobenzothiazole derivatives and their
dual activities as angiotensin converting enzyme inhibitors and calcium channel
blockers.
Praveen Kumar Kalavagunta, Pankaj K. Bagul, Anvesh Jallapally, Srinivas
Kantevari, Sanjay K. Banerjee, Narender Ravirala
Eur. J.Med. Chem. 2014, 83 (18), 344-354.
66. Design, synthesis and evaluation of 1,2,3-triazole-adamantylacetamide hybrids as
potent inhibitors of Mycobacterium tuberculosis.
Addla Dinesh, Jallapally Anvesh, Gurram Divya, Perumal Yogeeswari, Dharmarajan
Sriram, Srinivas Kantevari*.
Bioorg. Med.Chem.Lett. 2014, 24 (8), 1974-1979.
65. Rational design, synthesis and antitubercular evaluation of novel 2-(trifluoromethyl)
phenothiazine-[1,2,3] triazole hybrids.
Addla Dinesh, Jallapally Anvesh, Gurram Divya, Perumal Yogeeswari, Dharmarajan
Sriram, Srinivas Kantevari*.
Bioorg. Med.Chem.Lett. 2014, 24 (1), 233-236.
64. Rational design and synthesis of novel dibenzo[b,d]furan-1,2,3-triazole conjugates as
potent inhibitors of Mycobacterium tuberculosis.
Thirumal Yempala, Jonnalagadda Padma Sridevi, Perumal Yogeeswari, Dharmarajan
Sriram, Srinivas Kantevari*
Eur. J.Med. Chem. 2014, 71 (7), 160-167.
63. Synthesis of (aryl/heteroaryl)-(6-(aryl/heteroaryl)pyridin-3-yl)methanones
Dinesh Addla, Srinivas Kantevari*.
Res Chem Intermed. 2015, 41, 3759-3765.
62. Novel Synthesis of 6-Substituted 2-Picolines from Aryl/heteroaryl β-Enaminones and
Meldrum's Acid Using CeCl3.7H2O/NaI.
Dinesh Addla, Srinivas Kantevari*.
J. Heterocycl. Chem., 2014, 51 (S1), E384-E388.
61. Site selective acetoxylation of 5-aryl/ heteroaryl/ thiophenyl dihydro-6H-quinolin-5-ones
via Pd (OAc)2 catalyzed C-H activation.
Santhosh Reddy Patpi, Prabhakar Rao T, Balasubramanian Sridhar, Srinivas
Kantevari* RSC Advances 2013, 3, 10251-10261.
60. Identification of 10-substituted 2-hydroxy-2,3-dihydro-1H-benzo[e]pyrrolo [1,2-a] [1,4]
diazepine-5,11(10H,11aH)diones as potent Angiotensin Converting Enzyme (ACE)
inhibitors.
Dinesh Addla; Anvesh Jallapally; Abhinav Kanwal; Sridhar, Balasubramanian; Sanjay
Banerjee; Srinivas Kantevari*.
Bioorg. Med. Chem., 2013, 21, 4485-4493.
59. Design, Synthesis and antitubercular evaluation of novel 2-substituted-3H-benzofuro
benzofurans via palladium-copper catalysed Sonagashira coupling reaction. Thirumal
Yempala, Jonnalagadda Padma Sridevi, Perumal Yogeeswari, Dharmarajan Sriram,
and Srinivas Kantevari*
Bioorg. Med.Chem.Lett., 2013, 23(19), 5393-5396.
58. Rational Design, Synthesis and Biological Evaluation of Third Generation α-Noscapine
Analogues as Potent Tubulin Binding Anti-cancer Agents.
Naresh Kumar Manchukonda, Pradeep Kumar Naik, Seneha Santoshi, Manu Lopus,
Silja Joseph, Balasubramanian Sridhar, Srinivas Kantevari*
Plos One, 2013, 8(10): e77970.
57. Design, synthesis and antimicrobial evaluation of novel 1-benzyl 2-butyl-4-
chloroimidazole embodied 4-azafluorenones via molecular hybridization approach.
Dinesh Addla, Bhima, Balasubramanian Sridhar, Anjana Devi, Srinivas Kantevari*
Bioorg. Med.Chem.Lett., 2012, 22(24),7475-7480
56. Molecular hybridization of bioactives: Synthesis and antitubercular evaluation of novel
dibenzofuran embodied homoisoflavonoids via Baylis–Hillman reaction.
Thirumal Yempala, Dharmarajan Sriram, Perumal Yogeeswari, Srinivas Kantevari*.
Bioorg. Med.Chem.Lett., 2012, 22(24),7426-7430
55. Binding of alkali metal ions to Calix(4)pyrroles: An ESI-MS/MS and Theoretical Study.
Chinthapalli Dinesh Kumar, Vadla Naresh Chary, Patpi Santhosh Reddy, Kantevari
Srinivas, Yarasi Soujanya, Garikapati Narahari Sastry and Sripadi Prabhakar.
Rapid Commun. Mass Spectrometry, 2011, 25(19): 2815-2827.
54. Design, synthesis and structure-activity correlations of novel dibenzo[b,d] furan,
dibenzo[b,d]thiophene and N-methylcarbazole clubbed 1,2,3-triazoles as Potent
Inhibitors of Mycobacterium tuberculosis.
Santhosh Reddy Patpi, Lokesh Pulipati, Perumal Yogeeswari, Dharmarajan Sriram,
Nishant Jain, Balasubramanian Sridhar, Ramalinga Murthy, Anjana Devi T, Shasi
Vardhan Kalivendi, and Srinivas Kantevari*
J. Med. Chem., 2012, 55 (8), pp 3911–3922.
53. Copper (I) mediated facile synthesis of potent tubulin polymerization inhibitor, 9-amino-
α-Noscapine from natural α-Noscapine.
Naresh K. Manchukonda, Balasubramanian Sridhar, Pradeep K. Naik, Harish C. Joshi,
Srinivas Kantevari
Bioorg. Med.Chem.Lett., 2012, 22(8), 2983-2987
52. Synthesis and characterization of cell-permeant 6-nitrodibenzofuranyl-caged IP3.
Srinivas Kantevari, Yossi Buskila, and Graham CR Ellis-Davies
Photochem. Photobiol. Sci., 2012, 11, 508-513.
51. 3-O-Acyl triggered tandem Lewis acid catalyzed intramolecular cyclization of diacetone
glucose derivatives to 5-O-acyl-3,6-anhydro-D-glucose.
Rajashaker Bantu, Hari Babu Mereyala, Lingaiah Nagarapu, Srinivas Kantevari.
Tetrahedron Letters, 2011, 52(38), 4854-4856.
50. Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded
chalcones and pyrazoles as Angiotensin Converting Enzyme (ACE) inhibitors.
Srinivas Kantevari, Dinesh Addla, Pankaj K. Bagul, Balasubramanian Sridhar, Sanjay
K. Banerjee.
Bioorg. Med. Chem., 2011, 19 (16), 4772-4781.
49. Synthesis and antitubercular evaluation of novel dibenzo[b,d]furan and 9-methyl-9H-
carbazole derived hexahydro-2H-pyrano[3,2-c]quinolines via Povarov reaction.
Srinivas Kantevari, Thirumal Yempala, Govardhan Surineni, Balasubramanian Sridhar,
Perumal Yogeeswari and Dharmarajan Sriram.
Eur. J. Med. Chem., 2011, 46(10), 4827-4833.
48. Facile diversity-oriented synthesis and antitubercular evaluation of novel aryl and
heteroaryl tethered pyridines and dihydro-6H-quinolin-5-ones derived via variants of
Bohlmann-Rahtz reaction.
Srinivas Kantevari*, Santhosh Reddy Patpi, Dinesh Addla, Siddamal Reddy Putapatri,
Balasubramanian Sridhar, Perumal Yogeeswari and Dharmarajan Sriram.
ACS Comb. Sci., 2011, 13, 427-435.
47. A practical guide to the synthesis and use of membrane-permeant acetoxy methyl
esters of caged inositol-polyphosphates
Srinivas Kantevari, Graham C R Ellis-Davies
Nature Protocols, 2011, 6(3), 327.
46. Rational design, synthesis and biological evaluations of amino-noscapine: a high
affinity tubulin-binding noscapinoid.
Pradeep K. Naik, Biswa Prasun Chatterji, Surya N. Vangapandu, Ritu Aneja, Ramesh
Chandra, Srinivas Kanteveri and Harish C. Joshi
J. Comput. Aided Mol. Des., 2011, 25, 443-454.
45. Synthesis and antitubercular evaluation of amidoalkyl dibenzofuranols and 1H-benzo
[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-ones
Srinivas Kantevari, Thirumal Yempala, Perumal Yogeeswari, Dharmarajan Sriram and
Balasubramanian Sridhar
Bioorg. Med.Chem.Lett., 2011, 21(14), 4316-4319.
44. Synthesis and evaluation of deep cavity imidazolyl calix[n]arenes
H. M. Chawla, S. Kumar, N. Pant, A. Santra, K. Srinivas, N. Kumar, David StC. Black
J. Incl. Phenom. Macrocycl. Chem., 2011, 71, (1-2), 169-178.
43. Synthesis and antitubercular evaluation of novel substituted aryl and thiophenyl
tethered dihydro-6H-quinolin-5-ones
Srinivas Kantevari , Santhosh Reddy Patpi, Balasubramanian Sridhar, Perumal
Yogeeswari, Dharmarajan Sriram.
Bioorg. Med.Chem.Lett., 2011, 21, 1214-1217.
42. Photochemically initiated intracellular calcium astrocytic waves in living mice using
two-photon uncaging of IP3.
Sarah E Crowe, Srinivas Kantevari, Graham Ellis-Davies
ACS Chemical Neuroscience, 2010, 1 (8) 575-585.
41. Two-color, two-photon uncaging of glutamate and GABA.
Srinivas Kantevari, Masanori Matsuzaki, Yuya Kanemoto, Haruo Kasai & Graham C
R Ellis-Davies.
Nature Methods, 2010, 7(2), 123-126.
40. Cerium (III) catalyzed facile synthesis of dihydrobenzofuran tethered pyridines and
dihydro-6H-quinolin-5-ones from β-enaminones.
Srinivas Kantevari* Dinesh Addla and Balasubramanian Sridhar
Synthesis, 2010, 3745-3754.
39. Synthesis of novel acyclo-C-nucleoside analogues from L-Rhamnose via variants of
Bohlmann-Rahtz reaction.
Srinivas Kantevari* and Siddamal Reddy Putapatri
Synlett, 2010, 2251.
38. A new one-pot three-component, solvent free synthesis of amidoalkyl dibenzofuranols
and dibenzofuran-condensed 1,3-oxazin-3-ones.
Srinivas Kantevari*, Thirumal Yempala and Srinivasu V N Vuppalapati
Synthesis, 2010, 959-966.
37. A formal enantioselective synthesis of (+)-dodoneine via cyclic sulfate methodology.
Srinivasu V N Vuppalapati, Siddamal Reddy Putapatri and Srinivas Kantevari*
ARKIVOC, 2009, XIV, 217-226
36. An efficient one pot-three component synthesis of 4-Phenyloctahydro pyrano[2,3-d]
pyrimidin-2-one derivatives.
Srinivas Kantevari,* Srinivasu V. N. Vuppalapati, Rajashaker Bantu, Lingaiah
Nagarapu
J. Heterocycl. Chem, 2010, 47, 687.
35. An Efficient One-Pot Three Component Synthesis of 1,2-Dihydro-1-aryl naphtho[1,2-
e][1,3] oxazin-3-ones using Montmorillonite K10 under solvent free conditions.
Srinivas Kantevari,* Srinivasu V. N. Vuppalapati, Rajashaker Bantu, Lingaiah
Nagarapu
J. Heterocycl. Chem., 2010, 47, 313.
34. Astrocyte-Mediated Distributed Plasticity at Hypothalamic Glutamate Synapses,
G. R.J. Gordon, K. J. Iremonger, S. Kantevari, G.C.R. Ellis-Davies, B. A. MacVicar,
and J. S. Bains*.
Neuron, 2009, 64, 391.
33. Microwave-assisted regioselective one-pot synthesis of trisubstituted pyridine scaffolds
using K5CoW12O40.3H2O under solvent free conditions
Srinivas Kantevari,* Mahankhali Venu Chary, Srinivasu V.N. Vuppalapati, N. Lingaiah
J. Heterocycl. Chem., 2008, 44(5), 1099.
32. Tetrabutylammonium bromide (TBAB) in iso-propanol: an efficient, novel, neutral and
recyclable catalytic system for the synthesis of 2,4,5-trisubstituted imidazoles
Mahankhali Venu Chary, Nallani Chakravarthula Keerthysri, Srinivasu V.N.
Vupallapati, N. Lingaiah, Srinivas Kantevari*.
Catalysis Commun., 2008, 9 (10), 2013-2017.
31. Catalysis by an ionic liquid: highly efficient solvent-free synthesis of aryl-14H-
dibenzo[a.j] xanthenes by molten tetrabutylammonium bromide under conventional and
microwave heating
Srinivas Kantevari, Mahankhali Venu Chary, A.P. Rudra Das, Srinivasu V.N.
Vuppalapati and N. Lingaiah
Catalysis Commun. 2008, 9(7), 1575-1578.
30. A facile synthesis of polyhydroquinoline via the Hantzsch reaction under solvent free-
conditions using Potassium dodecatungsto cobaltate trihydrate K5CoW12O40.3H2O
Lingaiah Nagarapu*, Subhashini Gaddam, Satyender Apuri, Rajashaker Bantu,
Srinivas Kantevari.
Letters in Organic Chemistry, 2008, 5(1), p60-64
29. Synthesis and antimicrobial activity of novel C-linked imidazole glycoconjugates
Lingaiah Nagarapu, A. Satyender, P. Rupa Rani, K. Radhika, G. Subhashini, Srinivas
Kantevari
Bioorg.Med.Chem.Lett., 2008, 18(3), 1167-1171.
28. A highly efficient regioselective one-pot synthesis of 2,3,6-trisubstituted pyridines and
2,7,7-trisubstituted tetrahydroquinolin-5-ones using K5CoW12O40·3H2O as a
heterogeneous recyclable catalyst
Srinivas Kantevari, Mahankhali Venu Chary and Srinivasu V.N. Vuppalapati
Tetrahedron, 2007, 63 (52), 13024-13031.
27. Synthesis and two photon photolysis of 6-(O-Nitroveretryl)-caged IP3 in living cells.
Srinivas Kantevari, Caroline J. Hoang, Jakob Ogrodnik, Marcel Egger, Ernst Niggli,
Graham C.R. Ellis- Davies
Chem Bio Chem., 2006, 7, 174-180.
26. Mass spectral studies of meso dialkyl, alkylaryl and cycloalkyl calyx(4)pyrroles under
positive and negative ion electron spray ionization conditions.
Bhaskar, G.; Prabhakar, S.; Ramanjaneyulu, G.S.; Vairamani, M.; Srinivas, V.N.V.;
Srinivas, Kantevari.
Journal of Mass Spectrometry, 2007, 42, 1194.
25. An Efficient Synthesis of 2,5-Diamino-1,4-Benzoquinon
Hari Babu Mereyala, Mahankhali Venu Chary, Srinivas Kantevari
Synthesis, 2007, 187.
24. An Efficient One-Pot Three Component Synthesis of Amidoalkyl Naphthols using
montmorillonite K10 under solvent free conditions.
Srinivas Kantevari, V.N.V. Srinivas, Lingaiah, Nagarapu
Catalysis Commun., 2007 , 8 (11), 1857-1862.
23.. MCM-41 catalyzed rapid and efficient one-pot synthesis of polyhydroquinolines via the
Hantzsch reaction under solvent-free conditions
Lingaiah Nagarapu*, M. Dharani Kumari, N. Vijaya Kumari, Srinivas Kantevari
Catalysis Commun., 2007 8 (12), 1871-1875.
22. HClO4–SiO2 and PPA–SiO2 catalyzed efficient one-pot Knoevenagel condensation,
Michael addition and cyclodehydration of dimedone and aldehydes in acetonitrile,
aqueous and solvent free conditions: Scope and limitations
Srinivas Kantevari, Rajashaker Bantu and Lingaiah Nagarapu
Journal of Molecular Catalysis A: Chemical, 2007, 269, 53-57
21. Efficient Synthesis of Aryl-14H-dibenzo[a.j]xanthenes using NaHSO4-SiO2 or 5%WO3/
ZrO2 as Heterogeneous Catalysts under Conventional Heating in a Solvent-Free Media
Lingaiah Nagarapu, M. Baseeruddin, N. Vijaya Kumari, Srinivas Kantevari, A. P.
Rudradas
Synthetic Communications, 2007 (37), 2519 – 2525
20. Potassium dodecatugstocobaltate trihydrate (K5CoW12O40· 3H2O): A mild and efficient
reusable catalyst for the one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles under
conventional heating and microwave irradiation
Lingaiah Nagarapu, Satyender Apuri and Srinivas Kantevari
Journal of Molecular Catalysis A: Chemical, 2007, 266(1-2), 104-108.
19. HClO4–SiO2 as a novel and recyclable catalyst for the one-pot synthesis of homoallylic
amines
Lingaiah Nagarapu, Venkateswarlu Paparaju, Gopal Pathuri, Srinivas Kantevari,
Rupa Rani Pakkiru and Radhika Kamalla
Journal of Molecular Catalysis A: Chemical, 2007, 267, 53-56
18. Potassium dodecatungstocobaltate trihydrate (K5CoW12O40·3H2O): A mild and efficient
reusable catalyst for the synthesis of aryl-14H-dibenzo[a.j]xanthenes under
conventional heating and microwave irradiation
Lingaiah Nagarapu, Srinivas Kantevari, Venu Chary Mahankhali and Satyender Apuri
Catalysis Communications, 2007, 8, 1173-1177.
17. Potassium dodecatungstocobaltate trihydrate (K5CoW12O40·3H2O): A mild and efficient
reusable catalyst for the synthesis of β-acetamido ketones under solvent-free
conditions
Lingaiah Nagarapu, Srinivas Kantevari, Venkata Narasimhaji Cheemalapati,
Satyender Apuri and N. Vijaya Kumari
Journal of Molecular Catalysis A: Chemical, 2007, 264(1-2), 22-25.
16. Highly efficient, one-pot, solvent-free synthesis of tetrasubstituted imidazoles using
HClO4–SiO2 as novel heterogeneous catalyst
Srinivas Kantevari, Srinivasu V.N. Vuppalapati, D. O. Biradar and Lingaiah Nagarapu
Journal of Molecular Catalysis A: Chemical, 2007, 266(1-2), 109-113
15. Characterisation of a series of acetals/ketals of bis(2-nitrophenyl) ethanediol and
bis(4,5-dimethoxy-2-nitrophenyl) ethanediol under APCI mass spectrometric conditions.
Bhaskar, G.; Prabhakar, S.; Kumar, M. Ravi; Narsimhaji, Ch. V.; Srinivas, Kantevari.;
Vairamani, M.
Journal of Mass Spectrometry, 2006, 41, 1608-1614.
14. A practical synthesis of 5-(4'-methylbiphenyl-2-yl)-1H-tetrazole.
Srinivas Kantevari, C.K.S. Nair, M. Pardhasaradhi,
J. Heterocycl. Chem., 2006, 43, 1353-1356.
13. 13) TMSCl mediated highly efficient one-pot synthesis of octahydro quinazolinone and 1,8-
dioxo-octahydroxanthene derivatives
Srinivas Kantevari, Rajashekar Bantu, Lingaiah Nagarapu
ARKIVOC, 2006 136-148.
12. Bis(4,5-dimethoxy-2-nitrophenyl)ethylene glycol: a new and efficient photolabile
protecting group for aldehydes and ketones
Srinivas Kantevari, Ch. Venkata Narasimhaji and Hari Babu Mereyala
Tetrahedron, 61(24), 2005, 5849-5854.
11. A rapid and efficient synthesis of 2-butyl-5-chloro-3H-imidazole-4-carboxaldehyde.
Srinivas Kantevari, C.K.S Nair, M. Parthasaradhi,
Synthesis, 2004, 506.
10. An improved synthesis of 5-(2-flurophenyl)-1H tetrazole.
Srinivas Kantevari, CKS Nair and M. Pardhasaradhi, S. Ramesh
Org. Prep., Proc. Int., 2004, 36, 69-71.
09. A Novel and Efficient Synthesis of 9-(2-hydroxyethyl)-7,11-dioxaspiro [5,5] undecane
useful in the preparation of antiviral Acyclonucleoside.
Srinivas Kantevari, M. Pardhasaradhi, C. K. Snehalatha Nair, P. Srinagesh Kumar;
Tetrahedron Lett., 1998, 39, 7411-7412.
08. Synthesis of new bisazobiphenyl capped calix(4)arenes and their bearing on the
mechanism of mcalixarenes with amines,
H.M. Chawla and K.Srinivas ;
Ind. J. Chem., 1996, 35B, 181.
07. Synthesis of new chromogenic calix (4) arenas bridged at the upper rim through bisazo
biphenyl linkages,
H. M. Chawla and K. Srinivas.
J. Org. Chem., 1996, 61, 8464.
06. Calix-Quinone interactions: Molecular recognition of 2,6-naphthoquinone by
5,11,17,23, 29, 35-Hexa-tert-butyl-37,38,39,40,41,42-hexahydroxycalix (6) arene,
H.M. Chawla, K.Srinivas and Meena,
Tetrahedron, 1995, 51, 2709.
05. Molecular recognition of 2,6-naphthoquinone by 5,1,17,23,29,35-hexa-tert-butyl-37,38,
39,30,41,42-hexahydroxycalix (6) arene,
H. M. Chawla, K. Srinivas.
Indian J. Chem., 1995, 34B, 230.
04. Molecular Diagnostics: Synthesis of new Chromogenic calix (8)arenes as potential
reagents for detection of amines;
H. M. Chawla and K. Srinivas.
J. Chem. Soc., Chem. Commun. 1994, 2593.
03. Synthesis of new chromogenic calix (8)arenes;
H.M. Chawla, K.Srinivas.
Tetrahedron Lett., 1994, 35, 2925.
02. Synthesis of new fluorescent ionophores: First examples of calix-coumarin analogs;
H.M. Chawla and K.Srinivas.
J. Inst. Sci., 1994, 74, 515.
01. Synthesis of 25,26,27-Tris(ethoxycarbonylmethoxy)-28-(4’-methy-7’-coumarinyloxy
Carbonyl methoxy) calix(4)arenes.
H. M. Chawla and K. Srinivas.
Ind. J. Chem., 1993, 32B, 1162-1164.
13. Detail of patents:
No. of Patents granted / Applied 5
1) Malladi, Pardhasaradhi; Kantevari, Srinivas; Nair, Chembumkulam Kamala kshyamma Snehalatha. Process for the synthesis of 5-(2-fluorophenyl)-1H-tetrazole from 2-fluoro benzonitrile and an inorganic azide in the presence of an amine salt. U.S. (2001), 3 pp. US 6326498 B1 20011204 CAN 136:5996 AN 2001:875259 2) Malladi, Pardhasaradhi; Kantevari, Srinivas; Nair, Chembumkulam Kamalakshyamma Snehalatha. Synthesis of 5-(2-fluorophenyl)-1H-tetrazole. Jpn. Kokai Tokkyo Koho (2002), 10 pp. JP 2002284770 A 20021003 CAN 137:263040 AN 2002:747733
3) Pardhasaradhi, Malladi; Srinivas, Kantevari; Nair, Chembumkulam Kamalakshyamma Snehalatha; Das, Arun Kanti; Ramesh, Sunkanapally. Process for the preparation of 2-butyl-4-chloro-5-formylimidazole from valeronitrile. Indian (2004), 10 pp. IN 194591 A1 20041120 CAN 145:397516 AN 2006:907447 4) Pardhasaradhi, Malladi; Srinivas, Kantevari; Nair, Chembumkulam Kamalakshyamma Snehalatha. An improved process for the synthesis of 5-(2-fluorophenyl)-1h-tetrazole. Indian (2004), 9pp. IN 192966 A1 20040619 AN 2006:797987
5) Rao, Indarapu Balkishan; Das, Arun Kanti; Pardhasaradhi, Malladi; Prakash, Kamafajugadda Venkata Lakshminarayana; Nair, Chembumkulam Kamalakshyamma snehalatha; Srinivas, Kantevari. An improved process for the preparation of a alpha-formyl aryl acetates. Indian (2004), 9 pp. IN 192838 A1 20040522 CAN 145: 124293 AN 2006:745181
14. Dissertation Supervised
a) Ph.D
Completed 6 Ongoing 6
b) Post Graduation Completed 23 Ongoing 1
(A) Ph.D.
1 V.N.V Srinivasu (Awarded Ph.D., in Organic Chemistry, Nagarjuna University, Guntur, A.P.)
July 2010.
Thesis Title: Synthesis of biologically active natural products, synthesis and resolution of novel
dibenzofuranyl ethyl amine, Multicomponent construction of new heterocyclic scaffolds and
synthesis of chromogenic azacrown ether.
2 Siddamal Reddy Putapatri (Awarded Ph.D, in Organic Chemistry, Osmania University,
Hyderabad) December 2013.
Thesis title: Synthesis of L-rhamnose derived heterocyclic C-nucleosides as sodium
dependent glucose co-transporter inhibitors.
3 Y. Thirumal (Awarded Ph.D, in Organic Chemistry, Kakatiya University, Warangal)
December 2013
Thesis Title: Synthesis and Evaluation of Antitubercular / Photophysical properties of novel
dibenzofuran derived heterocycles.
4 Santosh Reddy
Thesis Title: Synthesis and Evaluation of Hybrid Heterocycles as Novel Antitubercular Agents
and Total synthesis of 5-Hydroxygoniothalamin.
5 A.Dinesh (Awarded Ph.D, in Organic Chemistry, Osmania University, Hyderabad). March 2014
Thesis Title: Studies on the synthesis of pharmacophoric Heterocyclic hybrids as potent
inhibitors of Angiotensin converting enzyme (ACE) and Mycobacterium Tuberculosis.
6 S. Goverdhan (Submitted thesis in Department of Chemistry, Kakatiya University, Warangal).
February 2014
Thesis Title: Synthesis and Biological evaluation of Carbazole,Dibenzofuran, Dibenzothiophene
derived heterocycles and photophysical properties of coupled carbazoles.
(B) M.Pharm / M.Sc. / M.Tech
23) Goutham Reddy, M. (June 2015 – September 2015) submitted to Department of I
Chemistry, Kakatiya University, Warangal for the award of Master of Science in 5 year’s
integrated Chemistry.
ThesisTitle: Synthesis of alkynones and their pyridine derivative.
22) Rakesh, K. (June 2015 – September 2015) submitted to Department of I Chemistry,
Kakatiya University, Warangal for the award of Master of Science in 5 year’s integrated
Chemistry.
ThesisTitle: Synthesis of piperonal from commercial vanillin.
21) Sai Kumar. P (July 2014 – September 2014) submitted to Department of Integrated
Chemistry, Palamuru University, Mahabubnagar for the award of Master of Science in 5
year’s integrated Chemistry.
ThesisTitle: Synthesis of novel 2-butyl-4-chloro-1H-imidazole-5-carbaldehyde derived
chalcones.
20) Geetha. G (Dec 2013-Dec 2014) submitted to Sarojini Naidu Vanita Pharmacy Maha
Vidyalaya, Faculty of Technology Osmania University, Hyderabad for the award of Master
of pharmacy in Pharmaceutical Chemistry.
Thesis Title: Synthesis and Biological Evaluation of Novel Derived Heterocycles.
19) Anuhya Goud. G (Dec 2013-Dec 2014) submitted to Sarojini Naidu Vanita Pharmacy
Maha Vidyalaya, Faculty of Technology Osmania University, Hyderabad for the award of
Master of pharmacy in Pharmaceutical Chemistry.
Thesis Title: Synthesis and Biological Evaluation of Novel Derived Heterocycles.
18) Vasanth Kumar. A (May 2013 – July 2013) submitted to Department of Chemistry,
Kakatiya University, Warangal for the award of Master of Science in 5 year’s integrated
Chemistry.
ThesisTitle: Synthesis of 9-bromo and 9 –amino-noscopines for cancer therapy.
17) Madhuri . D.S.R (Oct 2012 – Oct 2013) submitted to Department of Pharmacy, Krishna
University, Machilipatnam for the award of Master of Pharmacy in Pharmaceutical
Chemistry
Title: Derivatization of Natural Products as possessive Anticancer Agents.
16) Vani. T (Oct 2012-Oct 2013) submitted to Sarojini Naidu Vanita Pharmacy Maha
Vidyalaya, Faculty of Technology Osmania University, Hyderabad for the award of Master
of pharmacy in Pharmaceutical Chemistry.
Thesis Title: Synthesis and Biological Evaluation of Novel Derived Heterocycles.
15) Divya. G (Dec 2012-Dec 2013) submitted to Faculty of Technology Osmania University,
Hyderabad for the award of Master of Pharmacy in Pharmaceutical Chemistry.
Thesis Title: Synthesis and Antitubercular Evaluation of Novel 2-(trifluoro methyl)
phenothiazine-[1,2,3] triazole hybrids.
14) Anusha.T (Dec 2011-Dec 2012) submitted to Sarojini Naidu Vanita Pharmacy
MahaVidyalaya, Faculty of Technology Osmania University, Hyderabad for the award of
Master of pharmacy in Pharmaceutical Chemistry.
Thesis Title: Synthesis and Bio-evaluation of Novel Dibenzofuran based heterocycles.
13) Swetha.G (Dec 2011-Dec 2012) submitted to Sarojini Naidu Vanita Pharmacy Maha
Vidyalaya, Faculty of Technology Osmania University, Hyderabad for the award of Master
of pharmacy in Pharmaceutical Chemistry.
Thesis Title: Synthesis and Bio-evaluation of Novel heterocycles Derived from L-
Rhamnose.
12) Jilla soujanya (Dec 2011-Dec 2012) submitted to Faculty of Technology Osmania
University, Hyderabad for the award of Master of pharmacy in Pharmaceutical
Chemistry.
Title: Synthesis and evaluation of novel Substituted imidazole-Chalcone Hybrids as
Anticancer agents.
11) Anvesh Jallapally (Oct 2011-Oct 2012) submitted to Rajiv Gandhi University, Bangalore
for the award of Master of Pharmacy in Pharmaceutical Chemistry
Thesis Title: Design and Synthesis of Pyrrolobenzodiazepine derivatives as inhibitors of
Angiotensin converting enzyme.
10) Kunta Srinivas (June 2011- Sep 2011) submitted to Kakatiya University, Warangal for the
award of Master of Science in Chemistry.
Thesis Title: Synthesis of 2-Dibenzofuranol to construct biologically active novel
heterocycles.
09) Aluvala Santhosh Babu (June 2011- Sep 2011) submitted to Kakatiya University,
Warangal for the award of Master of Science in Chemistry.
Thesis Title: Synthesis of novel Sugar Chalcones from L-Rhamnose.
08) Enagandula Shyam Kumar (June 2011- Sep 2011) submitted to Kakatiya University,
Warangal for the award of Master of Science in Chemistry.
Thesis Title: Synthesis of novel 2-Butyl-4-chloro-1H-Imidazole-5-carboxaldehyde derived
Chalcones.
07) U. Padma (Feb –Aug 2010) submitted to Osmania University College for women, Koti,
Hyderabad for the award of Master of Science in Pharmaceutical Chemistry.
Thesis Title: Synthesis of novel bioactive heterocycles from L-Rhamnose.
06) 6) J. Jeevitha (Feb –Aug 2010) submitted to Osmania University College for women, Koti,
Hyderabad for the award of Master of Science in Pharmaceutical Chemistry.
Thesis Title: Synthesis and evaluation of novel imidazole analogues as Antimicrobial
agents.
05) Keerthi sri C (May 2006- June 2007) submitted to Vellore Institute of Technology, Vellore,
Tamilnadu for the award of M.Tech. Pharmacy.
Thesis Title: Synthesis of novel imidazole and pyridine derivatives as antifungal
compounds using solid and supported acid catalysts.
04) Rupa Rani Pakkiru (April 2005–March 2006) Submitted to Osmania University,
Hyderabad, India for the award of Master of Pharmacy (Pharmaceutical Chemistry).
Thesis Title: Synthesis of novel chiral resolving agents, carbohydrate intermediates,
2-substituted chiral imidazoles and analysis of primaquine diphosphate as per
pharmacopeia.
03) Shanthi Yadav Matla (April 2006) Submitted to Andhra University, Vishakhapatnam for
the award of Master of Pharmacy in Pharmaceutical Chemistry (Co-Guide)
Thesis Title: Synthesis and biological evolution of triazolyl antifungal agents, photolabile
ligands for study of photobionics and analysis of Noscapine as per pharmacopeia.
02) Sreelatha Kamalla (April 2006) submitted to Andhra University, Vishakhapatnam for the
award of Master of Pharmacy in Pharmaceutical Chemistry. (Co-Guide).
Thesis Title: Synthesis and biological evaluation of novel triazolyl antifungal compounds,
analysis of cetirizine as per pharmacopeia and the synthesis of impurities.
01) B.Sreedhar (March 2006) submitted to National Institute of technology (NIT),Warangal for
the award of Master in Science (M.Sc.) Industrial Chemistry. (Co-Guide).
Thesis Title: Process development for the synthesis of sulphonated amino biphenyl dyes
for printing inks.
( C) Ph.D., M.Sc.,M.Tech and M.Pharm Thesis Ongoing
1. Naresh Manchukonda (CSIR-SRF, Joined on June 18, 2010 in Ph.D. Programme).
2. Pulipati Lokesh (CSIR-SRF, Joined on June 18, 2010 in Ph.D. Programme).
3. 5. P. Naga Malleshwari (UGC-JRF, Joined on July 8, 2013 in Ph.D. Programme).
4. 6. Praveen Reddy ( UGC-JRF, Joined on December 10, 2013 in Ph.D. Programme).
5. 7. M.Sandeep Kumar (UGC-JRF, Joined on December 12, 2013 in Ph.D. Programme).
6. 8. D. Mahender (CSIR – JRF, Joined on January 01, 2015 in Ph.D. Programme).
15. Invited Lectures
18) Med-Science 2015 @CSIR-IICT, An interactive meet of Scientists & Medical professionals July 8, 2015. Title: Medicinal chemistry in drug discovery.
17) Delivered invited lecture in an national seminar “ Advances in Microbial Technology” being organised by the Department of Microbiology, Osmania University, Hyderabad from May 29-30, 2015. Synergising chemistry & biology: Application towards drug discovery
16) Delivered invited lecture in an International Conference “Asian Network for Natural & Unnatural Materials (ANNUM 3)” being organised by the Department of Chemistry Panjab University, Chandigarh from February 28, 2015. Title: Synchronizing chemistry and biology: Few examples from our journey towards drug discovery and diagnostics.
15) Delivered an invited lecture in National Seminar “ Bio-Adhyayan 2K15” at Osmania University, Organized by Avanti group of iNstitutions.25th Jan 2015. Title: Heterocyclic Compounds in Drug Discovery.
(Covered in National New papers 26th Jan 2015)
14) Delivered an invited lecture at International centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, 10th December 2014. Tiitle: Synchronizing chemistry and biology: An indispensable necessity to succeed in drug discovery.
13) Delivered an invited lecture in “Emerging Trends in Chemical and Pharmaceutical Sciences and Pharma Chem Expo-2014” Organized by Science Tech Foundation, 15-17 October, 2014, at CSIR-Indian Institute of Chemical Technology, Hyderabad. Title: Chemistry & biology of Heterocycles.
12) Talk on “Bioactive Heterocycles” 25th November, 2013 at National Institute of
Technology (NIT), Warangal.
11) Talk on "Synchronizing Biology and Chemistry - Translation approach to Drug discovery" on 1st August, 2013 at CSIR - Indian Institute of Chemical Technology,
Hyderabad. 10) Talk on “Noscapinoids: New generation natural α-noscapine analogues as potent tubulin
binding anti-cancer agents” International Conference and Exhibition on Pharmacognosy, Phytochemistry and Natural Products, October 21-23, 2013, Hyderabad, India (Abstract published in Biochem & Pharmacol 2013, 2:4 doi.org/10.4172/2167-0501.S1.004).
9) Presented on "Crop Protection Chemicals" in "Agro - Meet 2012" on 17 December, 2012
held at CSIR - Indian Institute of Chemical Technology, Hyderabad. 8) Presented in "2nd International Conference and Exhibition on Pharmaceutical
Regulatory Affairs" November 23-24, 2012, Hyderabad International Convention Centre
(HICC), India on "Hybridization strategies in the development of anti tubercular
agents"
7) Given talk in "Pest - Tech" on 16-18 August, 2012 at CSIR - Indian Institute of Chemical
Technology, Hyderabad. 6) Given Talk on "Supramolecular Chemistry: Principles and Applications" on 26
April, 2012 at Kakatiya University,Warangal. 5) Talk on "Supramolecular interactions: Principles and Applications in Medicinal
Chemistry" on 2nd April, 2012 at Jawaharlal Nehru Technological University (JNTU),
Hyderabad. 4) Invited lecture in Photolabile compounds to control cellular chemistry using photo release
technology APA International congress on Advances in Human Healthcare Systems Healthcare India, Feb 20-23, 2012, New Delhi India.
3) Invited lecture in International Conference & Exhibition on “Bioequivalence & Bioavailability 2010: Pharmaceutical R&D Summit”, March 1-3, 2010. Hyderabad.
2) Invited lecture in drug discovery and development at AICTE sponsored national conference on “Emerging trends in pharmaceutical sciences”, Feb 27-28, 2009, MNR College of
Pharmacy, Sangareddy, Hyderabad. 1) Invited lecture in drug discovery and development at UGC sponsored national seminar
on “New vistas in chemistry during 21st century” Sept 11-12, 2009, Department of
Chemistry UG & PG College, Kakatiya University, Warangal.