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ACUTE MYELOID LEUKEMIAACUTE MYELOID LEUKEMIA

(AML)(AML)

Presented by Judi McCarter

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Clinical Overview

Acute myeloid leukemia (AML) is one of four types ofleukemia.

AML is cancer of the blood-forming tissue (bone marrow).

Normal bone marrow produces red cells, white cells, and

platelets. AML causes bone marrow to produce too many immature

white blood cells (blast cells).

Suppresses normal blood cell production.

Anemia, leucopenia, thrombocytopenia

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Signs and Symptoms

Fatigue

Shortness of breath on exertion

Easy bruising

Petechiae

Bleeding in the nose or from the gums

Prolonged bleeding from minor cuts

Recurrent minor infections or poor healing of minor cuts Loss of appetite or weight loss

Mild fever

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11,920 new cases expected in U.S. in 2004

8,870 estimated deaths 2004 M:54%, F:46%

Statistics

5-year survival rate in adults under 65 is 33%

5-year survival rate in adults over 65 is 4%

Incidence:

Mortality:

Prognosis:

Prognosis:

Prognosis:

Incidence:

Mortality:

Prognosis:

Prognosis:

Prognosis: 20-30% experience remission or are cured

Sources: American Cancer Society, 2003; The Leukemia & Lymphoma Society, 2003

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Risk Factors Age

Older adults are more likely to develop AML

Smoking 20% of AML cases are linked to smoking

Doubles the risk of disease in people older than 60 Genetic disorders

Down syndrome, Fanconis anemia

High doses of radiation Long-term survivors of atomic bombs

Previous chemotherapy treatment Breast cancer, ovarian cancer, lymphoma

Exposure to industrial chemicals Benzene

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Treatments for AML

Chemotherapy

Phase One Remission induction therapy

Phase Two Remission continuation therapy Radiation therapy for certain cases

Bone marrow transplantation

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The Future

Clinical trials

New drug treatments

Vaccines

Immunotherapy

Leukemia type-specific therapy

Gene therapy Block encoding instructions of an oncogene

Target the oncoprotein

Blood and marrow stem cell transplantation Bone marrow transplantation provides long-term, disease-freesurvival among patients in remission

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Jillian had leukemia. She was only

one year old. She needed a

transplant, but no one in her family

was a match. Joe had joined the

Registry at the encouragement of a

friend. Brought together by the

National Marrow Donor Program,

this donor and recipient now have alife-long connection.

http://www.marrow.org

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1-800-4MY-SDBB 1-800-469-7322

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Questions??

Thank you.