Research Solution

• Bilcare Research offers a comprehensive packageof research solution for drugs and packagingmaterials, components and systems to support allyour manufacture and new product developmentactivities.

BilcareOptimaTM

* Sensitivity Profiling of solid dosage formulations

and

* Scientific Identification of Optimum Packaging

Applications of BilcareOptimaTM

New formulations Bottles Blister Alu-Alu Alu-Strips Double Packs

Optimum packaging

Product Parameters for Sensitivity

Profiling

• Hygroscopicity

• Degradation – Physical

– Chemical

• Drug release properties (DT and Dissolution)

• Mechanical properties (Hardness / Friability)

• Photosensitivity as a function of RH & Temperature

• Gas liberation tendency

• Dimensional aspects (Film Thinning)

All are studied under various conditions and identify the factors affecting

the degradation and its threshold values.

Identification of Optimum

Packaging Solution

Determine barrier requirements of package through mathematical modeling Moisture barrier requirements Light Barrier requirements Gas barrier requirements Dimensional requirements

Thinning profile through simulation software Defining Film structure

BilcareOptima is a professional service for customers to optimize the formulation

and determine optimum packaging.

Dimensional Aspects

• Thinning Profile on cavity formation using FEM software

• % Maximum, Minimum and Average thinning

• 3 D modeling of the blister Design using Solid work software

• Determination of Strip Area and blister area

Benefits of Bilcare OptimaTM

• Formulation sensitivity profiling

• Reduce analytical resource loading

• Shorten package development time

• Start stability test without worry

• End of over-packaging

• Long-term saving on materials

• Prevent under-packaging

• Prevent after sales quality issues

• Optimum packaging solutions