Biennial Report 2009 - 2011

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EDITORIAL 4

INTRO Department Professors 7Structure of the Department 8Events 10Awards 17Colloquia 21Staff News 23Plenary and Keynote Lectures 25

EDUCATIONOverview 28Evaluation 31Students’ Council 32Ten-Star Service 34Alumni 35 RESEARCHProcess Intensification 36

Polymer Science and Engineering 38Biotransformations 40Modeling 42Highlights 44Network 51The European Project Office 52

FACTS & FIGURESDoctoral Degrees 54Publications 57Graduates and Theses 58Patents 59Staff 60Students 61Finances 63Tuition Fees 64Infrastructure 66International Exchange 67Publications 68

CONTENTS

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Biennial ReportJuly 2009 - June 2011

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EDITORIAL

This is the second biennial re-port of our department which we prepare every two years on the occasion of the meeting of our Advisory Board. While the general orientation of the department has remained un-changed, continuous adapta-tions are being made in order

to cope with new challenges and to use new opportu-nities. Our mission statement that we formulated in 2008:Research and education for the development and op-timization of safe, sustainable and efficient production processes based on a strong interaction of natural and engineering sciencescontinues to define our efforts in teaching and in re-search.

With the appointment of Professor Dr. Oliver Kayser as a full professor in Technical Biochemistry who as-sumed his position on April 1, 2010, the extension and re-structuring of our research and teaching in biochemical engineering has been finalized. Thanks to the sponsoring of the BAYER AG, we could establish a new professorship in Equipment Design that has been assumed by Dr. Norbert Kockmann who joined us from Lonza, Switzerland, on April 1, 2011. The de-partment now is in a position to develop chemical and biochemical transformations from the foundations in chemistry, biochemistry and thermodynamics to their technical realization and systematic, model-based optimization. Our colleague Prof. Dr. Hans Fahl-enkamp who held the professorship in Environmental Technology retired on July 31, 2011, but some of his projects are still on-going. I wish to thank him warmly

for his contributions to the teaching and research of the department. We are very happy that our first stage programs, the Bachelor programs in Biochemical Engineering (BIW) and Chemical Engineering (CIW) are very well ac-cepted. In 2010 with enrollment restrictions in both programs, we could welcome about 180 first year students. In order to cope with the increasing num-bers of young people who want to start their univer-sity studies due to the reduction of the duration of the high school education and the abolishment of the military service, we removed the restriction for Chem-ical Engineering in 2011 and increased the intake to 110 for Biochemical Engineering.

In the transition to a Bachelor/ Master system, the department opted for a 7 semester Bachelor program which, in contrast to shorter programs, is planned such that the graduates are indeed employable by in-dustry. However, in all German universities currently the vast majority of the students opt for the continu-ation towards a Master degree. After our first experi-ences, we made some adaptations to the Bachelor programs and we now look forward to many years of operating a stable system. One major change was the modification of the introductory courses in the first semester in both programs where the students will now also work on small problems in groups to in-crease their motivation and help them to understand the importance of the basic subjects that are taught in the first semesters to real biochemical and chemi-cal engineering problems. We hope that this will con-tribute to a further reduction of the still considerable drop-out rate during the first semesters.

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EDITORIAL

While the beginning students are now educated ac-cording to the new rules, a large number of students have finished their Diplom-Ingenieur studies within the last two years and were in high demand both by the research groups of the department and by indus-try.On the Master level, we have been offering a spe-cialization in Process Systems Engineering as an international four semester English taught program for several years now. Up to now, the program has only been chosen by foreign students and by gradu-ates of German Fachhochschulen. After having coped with the adaptation of the learning strategies to the German university style of independent learning and requesting problem solving skills in the exams, the students perform well academically and are suc-cessful on the job market. Besides, the Department is strongly involved in the Master Programs in Polymer Science (together with the department of Chemistry and the FH Gelsenkirchen) and in Automation and Robotics (interdepartmental). It can be observed that the graduates of all these Master programs are also well accepted by the employers.The department puts significant efforts into the international dimension of the education of the stu-dents. Besides semesters abroad in the context of the European Erasmus scheme or organized indi-vidually, we can offer semesters abroad in top-level US universities and in Hong Kong, reciprocating the participation of their students in the Dortmund In-ternational Summer Program which is a unique low-threshold opportunity to study in Germany and was initiated and is still for a large part organized by our department. Thanks to the availability of funds from the Tuition Fees that were collected from 2007-2011, we could

invest significantly both in the infrastructure (lab experiments, computers, software etc.) and in stu-dent assistants for tutorials and in additional staff to improve the student-staff ratio. These fees also ena-bled the hiring of our Academic Coordinator whose work improved the information and counseling of the students as well as the coordination of the teaching activities very significantly. In 2011, a former storage area will be revamped into a student center to offer the students good working conditions for individual and group learning on the university premises. Over-all we will have spent more than 1,1 M€ on improve-ments of the learning conditions of the students from these fees. After the change of the provincial govern-ment, the tuition fees have been abolished and are replaced by a provincial program for the improvement of the quality of teaching, and we hope to be able to continue these activities as in the previous years.

The research of the department continued to grow in size and in impact. In 2010, we spent a record 6,89 M€ third party funding, for the first time surpassing our budget from the university and putting us in sec-ond place among the departments of the university. Besides a growing number of high-level publications the research of the department has been recognized in two really outstanding honors to members of our department: Gabriele Sadowski received a Leibniz-Prize of the German Research Council, and Andrzej Górak received the Bundesverdienstkreuz in recogni-tion of his contribution to the scientific cooperation with Poland. Congratulations! During the reporting period, we were very happy to be awarded a DFG Transregio-SFB on Integrated Proc-esses in Several Fluid Phases together with TU Berlin and the OvGU Magdeburg, the first time that several

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EDITORIAL

research groups of the department are involved in a SFB. A strength of the department is the high number of European projects and networks in which groups from the department participate which not only provide funding for research but also opportunities for interaction with researchers in many European countries for the young researchers in the depart-ment, adding an international dimension to their personal development. The management of and the application for such projects has been strongly sup-ported by the establishment of the EU project office of the department, sponsored by the Land NRW. In conjunction with the European Integrated Project F3, Bayer and TU Dortmund joined forces to set up a joint research and education facility in the area of process intensification in a public-private partnership. The INVITE Center in Leverkusen will be opened in Sep-tember and provide us with additional facilities for pilot scale and industrial scale developments.

Despite our continuing success in teaching and re-search, the department is facing significant challen-ges during the next years, in particular on the budget side. For the next years it is likely that we will have additional income from the extra funds for the additi-onal student intake, but in the long run TU Dortmund expects a significant reduction of the overall budget that is available for teaching and research. This will necessitate strategic discussions and decisions both on the university and on the department levels. Due to the uncertainty about our budget situation, we already had to put the process of hiring a new professor for environmental process engineering on halt. More than ever, we will need external funding and sponsoring to be able to continue to operate on our current level. Nonetheless we are confident that we will be able to maintain our high standards and will continue to be a member of the top-tier of similar departments in Europe.

Sebastian EngellDepartment Chair

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Laboratory of Process Dynamicsand Operations (DYN)Prof. Sebastian Engell

Laboratory of Particle Technology (MV)Prof. Peter Walzel

Laboratory of Plant and Process Design (APT)Prof. Gerhard Schembecker

Laboratory of Chemical Process Development (TCA)Prof. Arno Behr

Laboratory of Reaction Engineering (TCB)Prof. David W. Agar

Laboratory of Thermodynamics (TH)Prof. Gabriele Sadowski

Laboratory of Biomaterials and Polymer Sciences (BMP)Prof. Jörg C. Tiller

Laboratory of Chemical Biotechnology (BT)Prof. Andreas Schmid

Laboratory of Biochemical Engineering (BVT)Prof. Rolf Wichmann

Laboratory of Environmental Technology (UT)Prof. Hans Fahlenkamp

Laboratory of Fluid Separations (FVT)Prof. Andrzej Górak

Laboratory of Fluid Mechanics (SM)Prof. Peter Ehrhard

Laboratory of Technical Biochemistry (TB)Prof. Oliver Kayser

Laboratory of Equipment Design (AD)Prof. Norbert Kockmann

INTRO - DEPARTMENT PROFESSORS

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INTRO - STRUCTURE OF THE DEPARTMENT

The Department of Biochemical and Chemical Engi-neering is one of 16 departments at the Technische Universität Dortmund. The Department BCI consists of 14 laboratories. The Department Chair and the two Vice-Chairs administer the department and perform offi cial duties.

The central facilities support the work of the labo-ratories in research and education. The Chief Ad-ministrative Offi cer manages these facilities and is responsible to the Department Chair. The Academic Coordinator is responsible for all matters regarding students affairs.

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INTRO - STRUCTURE OF THE DEPARTMENT

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2009

Prof. Kim Dam-Johansen of the Technical University of Denmark (DTU) visits the Department of Biochemical and Chemical Engineering. (July 3rd)

The Department receives the „Hallmark of Excellence“ (Gütesiegel) of the Society of German Faculties for Mechanical and Chemical Engineering (FTMV e.V.). (July 9th)

Prof. Sebastian Engell chaired the IFAC Symposium on Advanced Process Control in Istanbul. (July 13th- 15th)

Ten stars for very good teaching service were awarded to the Laboratories of Fluid Mechanics, Fluid Separa-tions and Thermodynamics. (July 22nd)

The team of the Department of Biochemical and Chemical Engineering wins the national ChemCar-Competition 2009. (September 9th)

The new Advisory Board of the Department BCI discuss-es with the members of the Department BCI for the first time. (October 8th)

Biochemical and Chemical Engineering Open Day: the laboratories and working groups present their latest research results. At the graduation ceremony, the De-partment BCI conveys Bachelor, Master and Diploma degrees. (October 9th)

Participation in JOBtec at the Dortmund CineStar. (No-vember 11th)

The research proposal „Integrated Chemical Processes in Liquid Multiphase Systems“ (INPROMPT), part of the SFB/TR 63, is funded by the German Science Founda-tion. (November 18th)

Study Information Day. (November 19th)

The Department BCI takes part in the „Kinder-Uni“ (Chil-dren’s University). Titel of the presentation: What are

INTRO - EVENTS

Meeting of the Advisory Board 2009 ChemCar-Award 2009

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INTRO - EVENTS

synthetic materials are able to do? – About baby dia-pers, Lego bricks and football boots. (November 20th)

The project meeting of the EU-project EMBOCON takes place at the Laboratory of Process Dynamics and Opera-tions. (December 3rd)

Signing of the cooperation agreement between the Department of Biochemical and Chemical Engineering and the Technical University of Denmark (DTU), Lyngby. (December 14th)

The European Project Office, part of the Department of Biochemical and Chemical Engineering, is founded. It offers project management services to all researchers from Technische Universität Dortmund. (December 17th)

2010

In the course of Ruhr 2010, Capital of Culture, every month the Department BCI provides for the BCI homepage one artistic image of its research results (Engineering Meets Art)

Study Information Day. (March 4th)

Kick-off Meeting of the project „European Multilevel Integrated Biorefinery Design for Sustainable Biomass Processing (EuroBioRef)“. (March 22nd)

On the Girls Day, the participants are given an insight into the work of the Department. (April 22nd)

Priv. Doz. Lars Blank gives his inaugural lecture “Sys-tems Biotechnology and Biocatalysis”. (April 28th)

Seminar lecture Prof. Shah: “The new role of digital au-tomation systems in process monitoring: Sensor-fusion and signal processing for plant health management“. (April 28th)

The Department BCI opens its doors for the campus fes-tival. (June 19th)

The students’ council takes part in the “Stillleben”, a cul-tural activity on the closed A40 motorway. (July 19th)

The Laboratory of Prof. Kayser achieved the success-ful heterologous biosynthesis of Tetrahydrocannabinol (THC) in microorganisms. (August 18th)

The Department BCI participates with different activi-ties in the „SchnupperUni“ [A Taste of University]. (Au-gust 26th)

Prof. Dr. Gabriela P. Henning from INTEC Universidad Nacional del Litoral, Santa Fe, Argentina gives a course “Conceptual models and their applications”. (September 13th -15th)

Engineering Meets Art. Picture submitted by Dipl.-Inf. Martin Hüfner & Dipl.-Ing. Stephan Fischer, Laboratory of Process Dynamics and Operations

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The Process Dynamics and Operation Group celebrates its 20th anniversary with an international colloquium on “Perspectives in Process Operations”. (September 17th)

Participation in JOBtec at the Dortmund CineStar. (September 29th)

A student team from the Department BCI takes 4th place at the ChemCar-Competition 2010. (September 30th)

The Minister for Innovation Svenja Schulze, visits the INVITE-Center at Bayer AG in Leverkusen, a project in which the Department Biochemical and Chemical Engi-neering is closely involved. (October 4th)

Biochemical and Chemical Engineering Open Day: the laboratories and working groups present their latest research results. The program includes the graduation ceremony, the Department bids farewell to the gradu-ates. (October 8th)

The Department conducts the first professional train-ingworkshop for the secretaries of the Department. (November 22nd)

Melik Bugra Dogru is the first graduate of the new Mas-ter Program Process Systems Engineering. (December 2nd)

Biotrends 2010 conference organised by the Research and Development Network ChemBiotec and the Labo-ratory of Technical Biochemistry at the TU Dortmund. (December 1st-2nd)

2011

Kick-off Meeting of the project “Energy Efficiency Ma-nagement”. (January 27th)

The conference eLEARNing-TuDO2011 takes place at TU Dortmund. Dipl.-Inf. Martin Hüfner, Laboratory of Pro-cess Dynamics and Operations, presents the web-based

INTRO - EVENTS

Degree certificate conferral in graduation ceremony

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INTRO - EVENTS

learning program Learn2Control, which supplements the classical engineering education at the Technische Universität Dortmund. (January 28th)

The international Symposium “Challenges in Fluid Sepa-rations” takes place at the TU Dortmund on the occasion of the 60th birthday of Prof. Dr. Andrzej Górak. (February 18th)

Gottfried Wilhelm Leibniz Prize awarded to Prof. Dr. Gabriele Sadowski. (March 16th)

Study Information Day. (March 17th)

The Department BCI obtains financial support from TeachingLearnIng for a new teaching project. The dona-tion is used to extend the lecture “Technische Biologie” towards project-oriented contets. (March 24th)

Prof. Sebastian Engell and M.Sc. Tiago Fiorenzano Finkler congratulate the first Master in Process Systems Engineering: M.Sc. Melik Bugra Dogru

The Laboratory of Thermodynamics organizes the Sym-posium “Thermodynamik 2011“. (March 25th)

On Girls’ Day, the participants are given an insight into the work of the Department. (April 19th)

Marlene Senftleben is the first Bachelor graduate in Chemical Engineering and Jens Kamplade is the first Bachelor graduate in Biochemical Engineering at the TU Dortmund. (April 7th)

Prof. Sebastian Engell visits R&D institutions in India as a member of a delegation of the European project EUCLID. (April 18th-23th)

First Workshop of the „Stiftung zur Förderung des Kokereiwesens in Technik und Wissenschaft“ and the Department of Biochemical and Chemical Engineering is conducted. (May 4th)

First Bachelor in CIW/BIW: B.Sc. Jens Kamplade and B.Sc. Marlene Senftleben with Prof. Sebastian Engell

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INTRO - EVENTS

“Perspectives in Process Operations“

International Colloquiumon the Occasion of the20th Anniversary of the

Process Dynamics and Operations Groupat TU Dortmund

September 17th, 2010

Speakers

Bjarne Foss, NTU Trondheim, NorwayProcess Control - Vertical and Horizontal Integration

Bruce H. Krogh, Carnegie Mellon University, Pittsburgh, USAVerification of Hybrid Dynamic Systems

Ignacio E. Grossmann, Carnegie Mellon University, Pittsburgh, USAProgress in Mixed-integer Programming and Applications in Process Systems Engineering

Gabriela P. Henning, Universidad Nacional del Litoral, Santa Fe, ArgentinaProduction Scheduling in the Process Industries - Trends, Challenges and Opportunities

Cesar de Prada, Universidad de Valladolid, SpainTrends and Needs in Process Control

Sebastian Engell, TU Dortmund, Germany20 Dynamic Years and More to Come

Norbert Kuschnerus, Bayer Technology Services, Leverkusen, GermanyFuture Automation in the Process Industries

Hans Georg Bock, IWR, Universität Heidelberg, GermanyWhat Separations Brought TogetherProf. Dr. Sebastian Engell

Prof. Gabriela P. Henning

Dr. Achim Küpper and Prof. Hans Georg Bock

Prof. Ignacio E. Grossmann and Prof. Cesar de Prada

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INTRO - EVENTS

Speakers

Welcome Addresses

Prof. Dr. Ursula Gather, Rector, Technische Universität Dortmund, GermanyProf. Dr.-Ing. Sebastian Engell, Vice Chair Department BCI, Tech-nische Universität Dortmund, GermanyJörg Hunold, Ministry of Innovation, Science, Research and Tech-nology of North Rhine-Westphalia, GermanyDr. Andreas Förster, Managing Director ProcessNet, DECHEMA , Germany

Lectures, Chairwoman: Prof. Dr. Gabriele Sadowski, Technische Universität Dortmund, Germany:

Prof. Dr.-Ing. Hans Hasse, University of Kaiserslautern, Germany:The driving forces of fluid process engineeringDr.-Ing. Helmut Mothes, Bayer Technology Services GmbH, Ger-many: Open innovation - a successful approach for challenges in fluid separationsProf. dr. ir. Andrzej Stankiewicz, Delft University of Technology, The Netherlands: Advancing fluid separations via fundamental concepts of process intensificationProf. dr. ir. André de Haan, Eindhoven University of Technology, The Netherlands: Challenges in exploiting ionic liquids as advanced fluids in future fluid separations

Lectures, Chairwoman: Prof.ssa Dott.ssa Elisabetta Brunazzi, University of Pisa, Italy:

Dr. Wilfried Seyfert, BASF SE, Germany: Fluid separation research - how to match academic haute cuisine and industrial barbecueProf. dr hab. inz. Stanislaw Ledakowicz, Technical University of Lódz, Poland: Abatement of NOx emission from chemical industryDr. Søren Bøwadt, European Commission, Belgium:Visions in chemistry - from virtual institutes to open innovationProf. Dr.-Ing. Günter Wozny, Technische Universität Berlin, Ger-many: Distillation - a science or a kind of artProf. Dr.-Ing. Andrzej Górak, Technische Universität Dortmund, Germany: Fluid separations - tradition with a promising future

International Symposium“Challenges in Fluid Separations”

TU Dortmund

February 18th, 2011

Prof. Dr. Sebastian Engell, Prof. Dr. Ursula Gather, Prof. Dr. Andrzej Górak, Dr. Andreas Förster, Jörg Hunold

Prof. Dr. Ursula Gather

Scientific staff, Laboratory of Fluid Separations

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INTRO - EVENTS

International Symposium“Thermodynamic”

TU Dortmund

March 25th, 2011

Speakers

Prof. Dr. Joachim Groß, Universität Stuttgart:Von Flüssigkeitstheorien zur Anwendung von Flüssigkristallen

Prof. Dr. Hans Hasse, Technische Universität Kaiserslautern:Molekulare Simulationen mit Kraftfeldmethoden: Von der Strukturfluider Systeme zu deren physikalisch-chemischen Eigenschaften

Dr. Kai-Martin Krüger, Evonik Industries AG:Was Polymere im Öl zu suchen haben

Dr. Klaus-Dieter Hungenberg, BASF SE:On-line Methoden zur Verbesserung der Sicherheit und Leistungvon Polymerisationsreaktoren

Prof. Dr. Ralf Dohrn, Bayer Technology Services GmbH:Messung von Phasengleichgewichten bei hohen Drücken:Eine immer neue Herausforderung

Prof. Dr. Gabriele Sadowski, Technische Universität Dortmund:2001-2011: 10 Jahre Thermodynamik an der TechnischenUniversität Dortmund

Prof. Dr. Gabriele Sadowski

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INTRO - AWARDS

Barbara and Prof. Dr. Andrzej Górak, Sabine Kelm-Schmidt, Joanna Górak and Dr. Markus Rostek

Federal Cross of Merit to

Prof. Andrzej Górak,

June 29th, 2010

Professor Dr. Andrzej Górak has been awarded the Federal Cross of Merit on ribbon (Verdienst-kreuz am Bande) of the Federal Republic of Germany on 29th of June 2010. The head of the Laboratory of Fluid Separations at TU Dortmund, who additionally is full professor at TU Lodz, received the high state award for his contribu-tions to mutual understanding and cooperation between Poland and Germany. 17

INTRO - AWARDS

Gottfried Wilhelm Leibniz Prize awarded to Prof. Dr. Gabriele Sadowski

Gottfried Wilhelm Leibniz Prizeawarded to Prof. Gabriele Sadowski

March 16th, 2011

A highly successful researcher at the interface of engineering and natural sciences, Gabriele Sadowski is a recognised authority in the international thermo-dynamics research community. Her research in the areas of polymer thermodynamics and statistical thermodynamic equations of state has been truly groundbreaking. Among her other achievements, Sadowski has extended the scope of the SAFT theory, used to create molecular models of fluids, to include polymer systems. Known as PC-SAFT, the equation of state which she developed has become an indus-

trial standard and is used in software packages to process and predict states. In her more recent work Sadowski has expanded the scope of thermodynamic research to the life sciences and the study of com-plex mixtures containing biologically derived agents and biological agents. This research in the emerging field of bio-thermodynamics is especially relevant to medical science and biotechnology, and, for instance, can contribute to the production of particulate phar-maceutical substances.

After completing her degree and doctorate at the Technical University of Leuna-Merseburg, Sadowski shifted the focus of her studies to process enginee-ring and completed her habilitation thesis in this discipline at TU Berlin in 2000. She was appointed Head of the Laboratory of Thermodynamics at the TU Dortmund in 2001 at just thirty-six years of age. Her numerous research awards and keynote lectures at leading international conferences testify Gabri-ele Sadowski‘s academic standing and expertise. In addition to initiating and coordinating a DFG Priority Program, Sadowski was Department Chair and a member of numerous academic advisory boards in the chemical industry. Her reputation for scientific excellence has enabled Sadowski to attract both top-class scientists from abroad as well as early career researchers to her projects.

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INTRO - AWARDS

2009

Poster Award: Rühl J., Blank L. M. and Schmid A.; “Selected P. putida strains can grow in the presence of high butanol concentrations”; DECHEMA Jahresta-gung Biotechnology, (2009); Mannheim. (September 8-10th)

Sonja Hermes and Katrin Sulzbacher receive the Bayer Technology Services (BTS) Prize for the best degrees (Diploma Certificate) in biochemical and chemical engineering. (October 9th)

Andreas Hofmann (Chemical Engineering) and Julian Treese (Biochemical Engineering) receive the Wacker Chemie Prizes for best intermediate diploma. (Octo-ber 9th)

The students’ council of the Department of Biochemi-cal and Chemical Engineering receives the „Lehr-preis“ of the TU Dortmund. (December 16th)

Katrin Sulzbacher (Laboratory of Plant and Process Design) receives a prize as the best graduate of the Department of Biochemical and Chemical Engineer-ing. (December 16th)

2010

Together with his working group at Lonza, CH-Visp, Norbert Kockmann wins the prestigious Sandmeyer-Preis 2010 of the Swiss Chemical Society for their ground-breaking work in the area of microreactor technology and its application to industrial chemistry. (February 11th)

Norbert Kockmann was awarded a prize as the ASME-ICNMM2009 outstanding researcher for his contributions on transport phenomena in microchan-nels. (June 23rd)

Professor Dr. Andrzej Górak is awarded the Federal Cross of Merit with Ribbon (Verdienstkreuz am Ban-de) of the Federal Republic of Germany. (June 29th)

Patrick Schmidt, Laboratory of Fluid Separations, is awarded the Springorum-Denkmünze of RWTHAachen. (August 31st)

Tim Roth, Laboratory of Fluid Separations, receives the second best presentation prize at the Distillation and Absorption 2010 conference. (September 15th)

Katharina Koch, Laboratory of Fluid Separations, re-ceives the second best poster prize at the Distillation and Absorption 2010 conference. (September 15th)

Axel Mescher, Laboratory of Particle Technology, re-cieves the Best Presentation Award at 23rd Annual Conference on Liquid Atomization and Spray Sys-tems, Brno (CZ). (September 16th)

Arnold EuckenPrize is awarded to Dr.-Ing. Feelly Rüther, Laboratory of Thermodynamics. (September 21st)

ProcessNet 2010: Poster Award to Monika Sellerberg, Laboratory of Particle Technology. (September 30th)

Thermodynamics-Colloquium: Lecture prize awarded to Christoph Held, Laboratory of Thermodynamics. (October 6th)

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INTRO - AWARDS

Bayer Technology Services (BTS) Prize winners 2009 and 2010

Daniel Sudhoff and Sebastian Heitmann receivethe Bayer Technology Services (BTS) Prize for thebest degrees (Diploma Certificate) in biochemical and chemical engineering. (October 8th)

Franziska Horbach (Chemical Engineering) and MalteFittkau (Biochemical Engineering) receive the Wacker Chemie Prizes for the best results in the bachelor courses in Biochemical and Chemical Engineering. (October 8th)

The Klaus-Goerttler Prize awarded to Dr.-Ing. HendrikKortmann, Laboratory of Chemical Biotechnology, for his outstanding PhD thesis. (October 14th)

The PSE Model-Based Innovation Prize 2010 is awar-ded to Ala Eldin Bouaswaig and Sebastian Engell, Laboratory of Process Dynamics and Operations. (October 15th)

Sebastian Heitmann, Laboratory of Fluid Separa-tions, receives the “Jahrgangsbestenspreis” of the “Gesellschaft der Freunde der TU Dortmund e.V.” for his diploma thesis. (December 16th)

2011

Gottfried Wilhelm Leibniz Prize 2011 is awarded to Prof. Gabriele Sadowski from the Laboratory of Thermodynamics. (March 16th)

Daniel Sudhoff receives the Hans-Uhde-Prize for his outstanding scholarly achievements in the chemical engineering programme. (March 29th)

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INTRO - COLLOQUIA

2009

Dr. Klemens Kohlgrüber, Bayer Technology Services, Leverkusen: “Neue Entwicklungen und Modellierun-gen von Apparaten für die Polymerherstellung und -aufbereitung”, (July 15th).

Priv. Doz. Dr. Christian Hertel, Deutsches Institut für Lebensmitteltechnik e.V., Quakenbrück: “Molekular-ökologische Aspekte von Laktobazillen in Lebens-mittelfermentationen”, (July 22nd).

Prof. Holger Wormer, TU Dortmund, Ombudsmann: “Dunkle Materie? - Vom Umgang mit Fälschungen, der Sicherung guter wissenschaftlicher Praxis und der Rolle des Ombudsmanns”, (October 21st).

P. Matulka / Prof. P. Ehrhard, TU Dortmund: “Experi-mente zur Partikeltrennung in laminarer Rohrströ-mung; Simulationen zur Partikeltrennung in lamin-arer Rohrströmung”, (October 28th).

Prof. Dr.-Ing. Ulf Plöcker, ehem. Evonik Degussa GmbH, Hanau: “Überleben in der Krise”, (November 4th).

M. Sellerberg / R. Karande, TU Dortmund: “Lamina-res Dispergieren; Application of segment flow microsystems to enzymatic catalysis”, (November 11th).

Prof. D. Agar / Prof. P. Ehrhard, TU Dortmund: “Kapil-lar-Mikroreaktoren; Mikrokanäle mit internen pro-grammierbaren Elektroden”, (November 18th).

2010

Prof. Dr. David J. Cole-Hamilton, University of St. An-drews, Fife, Schottland: “Biphasic hydroformylation of alkenes, using water, ionic liquids and/or super-critical fluids”, (January 6th).

Prof. Ireneusz Zbicinski, Technical University, Lodz, Polen: “Advanced analysis of spray drying process”, (January 20th).

Dr. Martin H. G. Prechtl, Universidade Federal do Rio Grande do Sul, Brasilien: “Molecular Ruthenium Hy-dride and Nanoscale Catalysts: Synthesis, Properties and Application in Catalysis”, (January 27th).

Dr.-Ing. habil. Lars M. Blank, TU Dortmund: “Systems Biotechnology and Biocatalysis”, (April 28th).

Prof. Dr. Udo Kragl, Universität Rostock: “Simulation, ionische Flüssigkeiten und Mikroverfahrenstechnik - Werkzeuge für die Prozessintensivierung enzyma-tischer Reaktionen”, (May 26th).

Prof. Juan A. Asenjo, University of Chile, Sandiago de Chile: “The Rational Purification of Proteins: Pro-teomics, Expert Systems, Modelling, Process Condi-tions and Optimization”, (June 2nd).

Prof. dr. ir. Luuk A. M. van der Wielen, TU Delft,Niederlande: “In-situ product recovery”, (June 9th).

Dr. Hans-Juergen Henkel, Akzo Nobel GmbH, Frank-furt-Höchst: “Entwicklung einer neuen Brenner-Technologie - vom Labor in die Praxis”, (June 16th).

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INTRO -COLLOQUIA

Prof. John Woodley, DTU Lyngby, Dänemark: “Future challenges for biocatalytic processes”, (June 30th).

Prof. Dr. Gerhard Kreysa, ehem. DECHEMA e.V., Frankfurt/M.: “Klima und Klimaschutz aus Sicht des Chemieingenieurwesens”, (July 7th).

Prof. Dr.-Ing. Andreas Pfennig, RWTH Aachen: “Glo-bale Bilanzen als Wegweiser für zukünftige Entwick-lungen in der Verfahrenstechnik”, (July 14th).

Prof. Xiong-Wei Ni, Director NiTech Solutions Ltd., School of Engineering and Physical Science, Heriot-Watt University, Edinburgh, UK: “Continuous crystal-lisation is right here and right now”, (October 13rd).

Prof. Dr.-Ing. Oliver Kayser, TU Dortmund: “Kombi-natorische Biosynthesen - neue Strategien zur Gewinnung pharmazeutisch relevanter Naturstoffe”, (October 13th).

ao Univ. Prof. Dr. Bernhard Lendl, TU Wien, Öster-reich: “Neue Entwicklungen der IR- und Raman-Spektroskopie für die Analytischen Wissenschaften”, (November 17th).

Prof. Dr. Piet van Leeuwen, Institute of Chemical Research of Catalonia (ICIQ), Tarragona, Spain: “Rho-dium catalyzed hydroformylation: New covalent and supramolecular ligands”, (December 1st).

2011

Dr. Robert Franke, Evonik Oxeno GmbH, Marl: “Großtechnische homogene Katalyse - Neue Ansätze für alte Probleme am Beispiel der Hydroformylierung”, (January 26th).

Prof. Dr.-Ing. Jerzy Mackowiak, ENVIMAC Engineer-ing GmbH, Oberhausen und Lehrbeauftragter TU Dortmund: “Fortschritte bei der Modellierung der Fluiddynamik und des Stofftransportes in den Trenn-apparaten der thermischen Trenntechnik (Antritts-vorlesung)”, (April 6th).

Prof. Christos Georgakis, Tufts University, Medford, Massachusetts, USA: “Data-Driven Optimization of Batch Processes: The Design of Dynamic Experi-ments”, (April 27th).

Dr. Matthias Rauls, BASF SE, Ludwigshafen: “Hoch-reinigung von Chemikalien durch Schmelzekristal-lisation - Industrielle Bedürfnisse und methodische Ansätze”, (June 1st).

Prof. Gabriele Sadowski, Prof. Jörg Tiller and Prof. Oliver Kayser, TU Dortmund: “Pharmazeutische Formulierungen”, (June 8th).

Prof. Dr. Stephan Scholl, TU Braunschweig: “Mikrosysteme für partikuläre Life Science-An-wendungen”, (June 15th).

Prof. Dr. Hans-Jürgen Federsel, AstraZeneca, Södertälje, Sweden: “Chemistry and Engineering as Key Contributors in the Development of Novel Drugs”, (June 29th).

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INTRO - STAFF NEWS

2010Dr. Lars Blank from the Laboratory of Chemical Bio-technology completes his Habilitation and qualifies as a professor. (January 13th)

New Chair: Prof. Dr. Andrzej Górak. (February 24th)

Prof. Dr. Oliver Kayser is appointed Director of the Laboratory of Technical Biochemistry. (April 1st)

Dr. Jerzy Mackowiak is awarded an honorary profes-sorship. (May 1st)

Prof. Dr. Andrzej Górak was awarded the Federal Cross of Merit with ribbon (Verdienstkreuz am Ban-de) of the Federal Republic of Germany. (June 29th)

2011Dr. Achim Hoffmann, leader of a research group in the Laboratory of Fluid Separations, passes away at the age of 42. (January 11th)

Prof. Dr. Gabriele Sadowski wins the Gottfried Wil-helm Leibniz Prize, Germany’s most prestigious research prize. (March 16th)

Prof. Dr. Norbert Kockmann is appointed Director of the Laboratory of Equipment Design. (April 1st)

New Chair / Vice Chair: Prof. Dr. Sebastian Engell (Chair) und Prof. Dr. Gerhard Schembecker (Vice Chair). (May 11th)

Dr. Daniela Zander from the Laboratory of Biomateri-als and Polymer Sciences completes her Habilitation and qualifies as a professor. (May 11th)

Engineering Meets Art. Picture submitted by Dipl.-Ing. Sebastian Heitmann from Laboratory of Fluid Separations

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INTRO - STAFF NEWS

Prof. Dr. rer. nat.Oliver Kayser

Prof. Kayser was appointed Director of the Laboratory of Technical Biochemistry of the Department of Biochemical and Chemical Engineering April 1st, 2010.

Born: 1967 in Recklinghausen, Germany

Education: 1986 - 1991 Pharmacy study at the Westfälische Wilhelms Universität Münster1991 – 1992 Predoctoral Fellow at the University of Florida, Gainesville, USA

PhD: 1992 – 1997 PhD Thesis at the Institute of Pharmaceutical Biology, FU Berlin, Germany

Postgraduate Qualification: 1998 – 2003 Institute of Pharmaceutical Technology, Biopharamacy and Biotech-nology, FU Berlin, Germany

Positions: 2003 – 2010 Professor for Natural Product Biosynthesis at the University of Groningen, The Netherlands

Research Interests- Biosynthetic pathways of secondary natural products in plants - Metabolic Engineering - Metabolomics - Synthetic Biology - Medicinal Plant Biotechnology - Applications to white biotechnology and pharmaceutical biotechnology

Prof. Dr.-Ing. Norbert Kockmann

Prof. Kockmann was appointed Director of the Laboratory of Equipment Design of the De-partment of Biochemical and Chemical Engineering April 1st, 2011.

Born: 1966 in Burgsteinfurt, Germany

Education: 1985 - 1991 Mechanical Engineering at Technische Universität München

PhD: 1991 – 1996 PhD Thesis at the Institute of Techni-cal Thermodynamics, Heat and Mass Transfer, Universi-tät Bremen

Positions:1997 – 2001 Messer Griesheim GmbH, Project manage-ment for air separation units and syngas plant2001 – 2007 Group leader at Lab of Design of Microsys-tems for Micro Process Engineering, Albert-Ludwigs-University of Freiburg, IMTEK2007 – 2011 Head of Microreactor Technology, Conti-nuous-flow reaction technology, Lonza AG, Visp, Schweiz

Research Interests- Modular equipment and plants - Micro process engineering- Process intensification - Transport phenomena in microstructured devices- Multiphase flow and particle generation

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Chemical Biotechnology (BT)

Blank, L. M., Heyland, J., Kortmann, H., Schmid, A.: Einzelzellanalyse und quantitative Physiologie für die systembiotechnologische Untersuchung der Protein-produktion in Hefen. Jahrestagung der Biotechnolo-gen, Aachen, Germany, September 21st-23rd, 2010.

Buehler, B., Blank, L. M., Schmid, A.: Biocatalysis meets Systems Biotechnology. Jahrestagung der Biotechnologen, Aachen, Germany, September 21st-23rd, 2010.

Buehler, B., Kuhn, D., Ebert, B. E., Blank, L. M., Schmid, A.: Ecoefficiency and metabolic evaluation of recom-binant microbial biocatalysts for specific carbon oxyfunctionalization. BioTrends 2010, Dortmund, Germany, December 1st-2nd, 2010.

Halan B., Schmid, A., Buehler, K.: Productive catalytic biofilms on solid support membrane aerated reac-tors: process design for fine chemical synthesis. DECHEMA Bioverfahrenstechnik an Grenzflächen, Potsdam, Germany, May 30th-June 1st, 2011.

Buehler, B., Collins, J., Brandenbusch, C., Kuhn, D., Park, J. B., Schrewe, M., Blank, L. M., Sadowski, G., Schmid, A.: Whole-cell biocatalysis in organic-aque-ous two-liquid phase systems. Frontiers 2011, Delft, The Netherlands, June 21st-22nd, 2011.

INTRO - PLENARY AND KEYNOTE LECTURES

Chemical Process Development (TCA)

Behr, A.: How to transfer homogeneous catalysis into a technical scale: the miniplant technique, 17th International Symposium on Homogeneous Catalysis, Poznan, Poland, July 4th-9th,2010.

Behr, A.: Use of carbon dioxide via catalytic conversi-ons of a lactone platform chemical, 11th Internatio-nal Conference on Carbon Dioxide Utilization, Dijon, France, June 27th-30th, 2011.

Equipment Design (AD)

Kockmann, N.: Transport limitations in multiphase-flow microreactors – Current status and challenges, Keynote lecture 1st Joint ETPFG-EFCE Multi-Phase Meeting, Bled, Slovenia, June 3rd-6th, 2009.

Kockmann, N.: Transitional Flow and Related Trans-port Phenomena in Complex Microchannels, Keynote lecture ICNMM09 ASME NanoMicroMiniChannels, Pohang, South Korea, June 22nd-24th, 2009.

Kockmann, N., Eyholzer. M., Gottsponer, M., Roberge, D.M., Brunner, A.: Microreactors in Pharmaceutical Industry-From Lab-Scale to Production, Keynote lecture GRAMS, Group for Research on Automated Flow and Microreactor Synthesis, Kinki Chemical Society, Japan, Osaka, August 7th, 2009.

Kockmann, N.: Microstructured Devices – Opport-unities in Lab R&D and Production, VDMA-Roadshow Mikrofluidik, Introductory lecture on 4 events in Germany, June 16th-30th, 2010.

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INTRO - PLENARY AND KEYNOTE LECTURES

Dittmeyer, R., Kockmann, N.: Mikroverfahrenstech-nik: Wo stehen wir mit der Apparate- und Prozess-entwicklung? Tandemvortrag auf der ProcessNet-Jahrestagung, Aachen, Germany, September 21st-23rd, 2010.

Kockmann, N., Roberge, D.M.: Continuous-flow Mi-croreactors for New Chemical Routes and Scale-Up from Lab to Production, invited keynote lecture 4th Siegfried Symposium, Zurich, Switzerland, Septem-ber 23rd, 2010.

Kockmann, N.: Sicherheitsrelevante Reaktionen in der Flüssigphase mit Mikroreaktoren, 671, Dechema Kolloquium, Frankfurt, Germany, October 28th, 2010.

Fluid Mechanics (SM)

Wälter, B., Ehrhard, P.: Numerical simulation ofelectrical double layers and internal electrodes in microchannels, Jahrestagung GAMM, Danzig, Polen, February 9th-13th, 2009.

Boettcher, K., Holbach, A., Ehrhard, P.: Radial spreading and stability of a thin rotating liquid droplet, Jahres-tagung GAMM, Graz, Österreich, April 18th-21st, 2011.

Particle Technology (MV)

Walzel, P.: Influence of spray method on product quality and morphology in spray drying, 17th Interna-tional Drying Symposium (IDS 2010), Magdeburg, October 3rd-6th, 2010.

Walzel, P.: Einfluss des Zerstäubungsprozesses auf die Produktparameter, APV-Seminar Sprühtrocknung zur Herstellung fester Arzneiformen, Fulda, Feburary 28th-March 1st, 2011.

Technical Chemistry B (TCB)

Agar, D. W.: Liquid-Liquid slug flow capillary microre-actors. 6th ERA-Chemistry Flash Conference, Roscoff, France, February 28th-March 4th, 2010.

Agar, D. W., Kreysa, G.: Decarbonisation of fossil fuels via methane pyrolysis. DGMK Int. Conf. Berlin Future role of hydrogen in petrochemistry and energy supply, October 4th-6th, 2010.

Agar, D. W.: Non-catalytic gas-solid reaction-modelling and measurement, ProcessNet 2010, Aachen, September 29th, 2010.

Engineering Meets Art. Picture submitted by Dipl.-Ing. Jan-Bernd Große-Daldrupfrom Laboratory of Plant and Process Design

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Engineering Meets Art. Picture submitted by Dipl.-Ing. Sven Kaiser from Laboratory of Environmental Technology

INTRO - PLENARY AND KEYNOTE LECTURES

Technical Biochemistry (TB)

Kayser, O.: Metabolic engineering strategies for the optimization of medicinal and aromatic plants: expectations and realities, ISMAP 2009, Lubljana, Slovenia, June 18th, 2009.

Kayser, O.: Metabolic engineering for improved heterologous terpenoid biosynthesis. 58th GA Meeting (Society for Medicinal Plants and Natural Product Research), Berlin, Germany, September 1st, 2010.

Kayser, O.: Development of phytochemicals into commercial pharmaceutical products (International Workshop), Yogjakarta, Indonesia, July 5th-8th, 2010.

Kayser, O.: Metabolic engineering for improved heterologous terpenoid biosynthesis, Terpenist, Istanbul, Turkey, September 27th, 2010.

Kayser, O.: Phytoöstrogene – ihre Chemie, Bio-chemie und Wirkung im Menschen, Phytoestrogene – Sekundäre Pflanzeninhaltstoffe mit tumorpräven-tivem Potenzial? (Workshop Phytomedizin), Rostock, Germany, December 10th, 2010.

Kayser, O.: Metabolic engineering of microorganisms for the production of terpenoids from plants. (Drug Discovery and Development Seminar) Basel, Switzer-land, March 28, 2010.

Thermodynamics (TH)

Sadowski, G., Held, C., Naeem, S.: Modeling of elec-trolyte and polyelectrolye systems, ProcessNet Work-ing Party “Molecular Modelling and Simulation for Process and Product Design” and the EFCE Working Party on Thermodynamics and Transport Properties, Würzburg, Germany, March 22nd-23rd, 2010.

Sadowski, G.: Modellierung von Polymer-Phasen-gleichgewichten unter hohem Druck, Fachausschuss Hochdruckverfahrenstechnik, Maribor, Slowenien, March 10th-11th, 2011.

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Engineering education – focused on fundamentals

According to the mission statement of the Depart-ment of Biochemical and Chemical Engineering, its study programmes are designed to optimally prepare and qualify graduates for their professional careers, enabling them to develop and improve material-conversion processes that are both ecologically sustainable and effective. This philosophy entails an intimate dovetailing of scientific and engineering coursework. Even though practical aspects are cov-ered in the broadly based and intensive lectures on fundamental principles, the syllabus remains basi-cally research-oriented.

The Department BCI offers two Bachelor’s programmes:

Biochemical Engineering Chemical Engineering

In the first three semesters of the Bachelor’s study programmes, teaching concentrates predominantlyon fundamental mathematics and scientific courses. For students in the biochemical engineering option, courses on the basics of biology and biochemistry are included. Fundamental engineering subjects are introduced in the third semester, and process engi-neering subjects are taught from the fourth semester onward. In addition, students can select a variety of elective courses. Further coursework on basic personal skills and technical English, complements the technical-scientific material.

EDUCATION - OVERVIEW

Besides lectures and tutorials, a significant number of practical courses are included within all degreeprogrammes. Laboratory practicals designed to im-part practical knowledge are incorporated to underpin the scientific and process engineering fundamental courses and their applied aspects. Industrial internships and excursions to industrial firms are an integral component of these practical courses.

The knowledge acquired within the first six sem-esters is utilised in the seventh semester during the process design project, which is carried out as a joint group project by 8 to 10 students. The task posed is an exercise in pre-planning design for an industrial production plant within a limited time frame and under realistic conditions. In the final Bachelor’s thesis, the students demonstrate their ability to conduct systematic and independent research work.

Following completion of the Bachelor’s degree, graduates can obtain postgraduate education in one of the following three Master’s degree programmes:

Biochemical Engineering Chemical Engineering Polymer Science

The Master’s study programme in Chemical Engineering offers students a choice of two specialisations in either:

Chemical Engineering (taught mainly in German) or Process Systems Engineering (taught entirely in English)

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EDUCATION - OVERVIEW

Apart from the mandatory study programme con-sisting of lectures and tutorials and laboratory practicals, the students can select elective courses according to their particular interests and chosen areas of specialisation. The Master’s study pro-grammes conclude with a Master’s thesis of six months’ duration.

Teaching Quality Assurance

The Department of Biochemical and Chemical Engineering has defined rules for the teaching quality assurance which lay down:

the objectives of quality assurancethe structures needed to ensure quality

assurancemeasures to further enhance the quality of

teaching by 2011 - 2013

In conjunction with the existing commission for teaching and studies and the examination commit-tee, a special commission has been established for the enhancement of the quality of teaching and studies, which will analyse the present status, identify shortcomings and propose countermeasures to the faculty council.

Innovative teaching projects

High drop-out rates of students in engineering study course programmes are common in Germany and are often caused by examination failures in the initial phase of the degree course. The existing situation is characterised by:

Too little systematic guidance and direct support of studies and scientific learning.

The fact that, during the first semesters, educa- tion takes place almost exclusively in external faculties. This leads to a certain alienation from the actual degree course. The students often have the impression that knowledge is being provided in isolation without an overall context, which first becomes apparent in a much later phase of their studies.

Exclusively ‘talk-and-chalk’ teaching in large groups. Lectures and non-interactive tutorials dominate.

Problems of a “commuter-university”. Students cannot always establish a social network, e.g. for learning groups. This can aggravate problems with motivation and performance.

Higher education entrance qualification after 12 (instead of previously13) years of primary and secondary education.

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From the analysis of these problems, the Depart-ment of Biochemical and Chemical Engineering has developed a new course teaching format for the first semester, for which the faculty has obtained external funding.

The trial run of this project work in the first semester of the Biochemical Engineering degree during the winter semester 2010/2011 was extremely success-ful and convinced TeachIng LearnIng, the competence centre for engineering education, to fund this innova-tive educational project with more than 15,000 €.

As of the winter semester 2011/2012, freshmen in both study course programmes will carry out project work in their first semester. After an initial lecture (“Industrial Biology” for biochemical engineering and

“Introduction to Industrial Chemistry” for chemical engineering) project work will be conducted in groups of three to five students.

This project work is intended to provide a bridge bet-ween everyday life and the future profession. Stimu-lating problems or applications encountered daily life will be investigated experimentally and then analysed using simple engineering tools.

The students will comes to understand how engineers approach the solution of a problem and which tools are required. Interdisciplinarity and perspectives will become tangible, hopefully strengthening the commit-ment to the chosen career path.Basic skills needed for studies (e.g. use of the library, proper citation, writing of reports) will be conveyed, as well as soft skills, such as team work, design of pos-ters and papers, presentation and time management.

The potential for generating of social contacts amongst the students and to the supervising doctoral students, who – even without an explicit mentoring programme – will be accessible for questions and advice, should not to be underestimated.

With the project work in the first semester, the De-partment of Biochemical and Chemical Engineering is embarking into promising territory. Contacts to the competence centre for teaching and learning in engineering science TeachIng LearnIng should help to avoid mistakes and guarantee success. A local indus-trial cooperation partner - Uhde GmbH - has declared its willingness to provide funding for the infrastructure necessary.

EDUCATION - OVERVIEW

Student Information Day

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EDUCATION - EVALUATION

Evaluation - An Instrument for Quality Assurance in Teaching

To ensure the high quality of the courses offered in the study programmes, the students evaluate the courses given by the teachers of the department.

Toward the end of the semester, all students receive questionnaires about the courses they have attend-ed. These forms are distributed by a representative of the Student ‘s Council and they are immediately filled out and collected without being viewed by the instructor. The lecturers are informed of the results of the questionnaires, but all comments remain anony-

mous. The evaluation results are posted (without comments) in the Department BCI and mailed to all students and scientific staff in the department.

Once a semester, the Commission for Teaching and Studies examines the teachers’ evaluation results. It makes suggestions about certain courses, but it can also take measures on a more general scale, for instance, to deciding that a lecturer must attend a further training course. In the case of a negative eval-uation, the Commission for Teaching and Studies will organise a consultation with the lecturer concerned to try to eliminate the problems in the future.

Average Results of the Evaluation

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The Students’ Council is an elected group of students in the Department of Biochemical and Chemical Engineering, representing the interests of their fel-low students. The main focus of its work lies on the improvement of study conditions and the quality of teaching. For this purpose, the Students’ Council meets once a week to discuss current issues. In order to influence the department’s decisions and poli-cies, members of the Students’ Council participate in all committees, e.g. the Department Council, the Teaching and Studies Commission, the Budget and Structures Commission, the Commission for the dis-embursement tuition fees and the Public Relations Committee.

The Students’ Council itself is organised in sev-eral working groups, for example Public Relations, Evaluation, Homepage, Party, Old Exams, Students’ Studyroom and, especially, the 10-Star-Service. The 10-Star-Service was introduced in 2008 and rates the performance of the department’s laboratories in different categories such as teaching, exams and availability of the teaching staff. This rating influ-ences the distribution of the department’s budget to the different laboratories. Furthermore, the Students’ Council organises tutorials and revision courses for exams. It has direct contact to the Students’ Union Executive Commission, to the Department Chair and external organizations. All students are regularly informed about the Students’ Council’s activities via circular emails or its homepage.

EDUCATION - STUDENTS’ COUNCIL

The Students’ Council 2011

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EDUCATION - STUDENTS’ COUNCIL

The Department of Biochemical and Chemical Engi-neering and the Students’ Council have been work-ing together successfully for many years. The main achievements of this cooperation in the last two years were the following:

Improvement of the 10-Star-Service

Modification and improvement of the course of study in the bachelor’s and master’s programmes

Public relations work for many local events, including a stall on the motorway A40 as part of the project “European Capital of Culture 2010” and schools’ open days

organisation of tutorials in many subjects for all students of the department

Counselling of pupils during the University Open Day or the Consulting Night

Organisation of orientation programmes for freshmen, e.g. the orientation week, the “Doing”-programme, which provides information about the university’s daily procedures, or a 3-day-field trip for socialising and meeting fellow freshmen

Social events for students

Planning of a modern students’ workroom with workspace for over 50 students, realized from the tuition fees

The students’ workroom: opening from winter term 2011

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EDUCATION - TEN-STAR SERVICE

The Ten-Star Service: Quality Control for good Study Conditions

In June 2008 binding service rules for teaching and studying were agreed upon between the Department BCI and the students. These “Ten-Star Service” rules define the Departments obligations toward the stu-dents and include following points:

Teaching in FocusExaminationsDiploma thesesLetters of Recommendation and CertificatesAvailabilityComplaint managementStudy Information and Lecture MaterialsEvaluation and TeachingWork space and InfrastructureLaboratory courses

Once a year the stars are awarded to the Laborato-ries.Following Laboratories have fulfilled all points in the undertaking and received ten stars:

2009

Laboratory of Fluid MechanicsLaboratory of Fluid SeparationsLaboratory of Thermodynamics

2010

Laboratory of Environmental TechnologyLaboratory of Fluid SeparationsLaboratory of Thermodynamics

10-Star Service: Winner 2010

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Alumni of the Department of Biochemical and Chemical Engineering

The Department of Biochemical and Chemical Engineering has its own section in the Association of Alumni of the Technische Universität Dortmund, the Friends‘ Association (Freundegesellschaft).

The Department is proud of its graduates, who have been successful all over the world, and who, in some cases, still take an active interest in the life of their alma mater, giving both moral and financial support by, for example, giving lectures to the students and members of the Department, taking teaching as-signments, the supervision of group projects or term assignments, or donations.

In return, they are informed about the latest research projects and the results of research through a news-letter send out twice a year. In addition, the alumni can acquaint outstanding graduates with their com-panies as potential employers.

For the future, in addition to the annual Open Day of the Department of Biochemical and Chemical Engi-neering‘, the Department‘s plans include more events and establishing a discussion forum. Polls of gradu-ates will allow courses to be adapted more rapidly to the changing requirements of industry.

Finally, the Alumni Association offers an opportunity for meeting former fellow-students and for making new professional contacts.

First BCI Alumni newsletter, January 2011

EDUCATION - ALUMNI

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Introduction to Research

Besides their excellent work in the classical research fields, the Department has specialised in the follow-ing main areas:

Process Intensification Polymer Science and Engineering Biotransformations Model-based Design & Operation

Process Intensification

The goal of process intensification is to enable a chemical or biological process to achieve its maxi-mum performance liberated from extraneous trans-port resistances and dispersive statistical phenom-ena. Crucial aspects of process intensification are well-defined operating conditions and its integrative approach, which considers the overall process objec-tives and integrates the individual characteristics of single process steps. Due to often extreme pro-cess conditions, tight operating windows of coupled process and their non-linear behavior, integrated processes form challenging control and equipment issues.

The Department of Biochemical and Chemical Engi-neering has gained considerable experience in the area of process intensification e.g. in a joint research initiative on intergrated reaction and separation processes funded by German Research Council. At the moment many projects on reactive extraction, membrane-assisted distillation, and absorption processes are performed in some laboratories.Microstructured devices allow for enhanced heat and mass transfer rates and controlled process condi-tions and can improve the performance of chemical and biochemical processes. The Depatment has wide experience with design and application of microreac-tors and expands their field by downstream process-ing steps and a consistent scale-up strategy from lab development to pilot production. A continuous-flow plant with static-mixer-heat exchange elements is currently under investigation for polymerization. Further current research fields are modular design and their fabrication from various materials, catalyst coatings, profound characterization of fluid dynamics

RESEARCH - PROCESS INTENSIFICATION

36

RESEARCH - PROCESS INTENSIFICATION

and transport phenomena, as well as application in polymerization, particle formation, and others.Catalytic research falls also under process inten-sification measures, where the Department has high-profile international reputation. Modification of solubility properties of homogeneous catalyst and ef-ficient use of non-uniform activity in heterogeneous catalysis are, amongst others, active research areas. Integration of catalytic material in microstructured reactors is a viable research area, which benefits from the enhanced transport characteristics and adapted catalytic activity. Wider integration and rationalization of chemical plants in the context of process synthesis, optimization of batch scheduling and transformation of batch recipes to continuous processes are further topics in process intensifica-tion, in which the Department possesses consider-able expertise.

Not only equipment and processes contribute to intensification, but also the choice of reagents and solvents can start and accelerate chemical and bio-chemical transformations. Ionic liquids with tunable characteristics and catalytic activity are investigated in this context, carbon dioxide serves as supercriti-cal solvent or as raw material for advanced polymers, and precious catalyst can easily be recovered by design solvents. In the last years considerable ef-fort has been invested into the research of alterna-tive energy sources to initiate and control reaction, for instance microwave irradiation for volumetric heat transfer, and into beneficial effects of counter-current flows under centrifugal fields for enhanced mass transfer and two-phase dispersion.

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Polymer Science and Engineering

The Department of Biochemical and Chemical Engineering has intensified the research and teaching involving polymers over the last two years. The number of student research projects together with bachelor, diploma, master and PhD theses on the subject of polymers and polymerization has been increased significantly. Furthermore, the production of monomers and polymers has also been addressed in several group plant design projects.The joint Master’s programme with Gelsenkirchen Polytechnic in the field of polymer science graduated its first master in polymer sciences in 2009. Since then, several more graduates have finished their studies with master theses carried out at laboratories in BCI and the Chemical Department as well as in industry. The Master’s programme will be re-accredited in 2012. The polymer-oriented research in the Department BCI is spread over a wide range of topics, covering polymer design, modelling, processing, polymer physics, product design, and applications of polymers, such as protein separation, biocatalysis, and antifouling techniques.

The following groups are involved in this research:

Biomaterials and Polymer Sciences: The Biomaterials and Polymer Sciences Group is generally interested in polymer designs that interact with or mimic biological elements or systems. We are currently working on designs that can be applied as smart materials (Polymer 2010), energy storage systems (Adv. Mater. 2011a), separation techniques (J. Membran Sci 2011), ultrahydophobic mimics of crokea leaves (Adv. Mater. 2011b) as well as in anti-

fouling systems (Macromol. Biosci. 2011). Future research work of BMP will address the development of novel smart dynamic shape memory systems. Furthermore, it is planned to develop switchable biocidal polymers and non-toxic polymeric disinfectants. The development of hybrid enzyme/inorganic tandem catalysts is also currently in focus.

Fluid Separations:Dense polymeric membranes are often used as semipermeable materials to separate fluid mixtures into single components. In the Laboratory of Fluid Separations, several kinds of membranes have been used in organophilic nanofiltration, pervaporation and vapour permeation process to separate multicomponent organic mixtures. “The Material by design” approach has been established, in which the membrane manufacturer supply the desired polymer properties, which are then tested in experimental cells in the Laboratory and applied in pilot-scale plant with the help of membrane module providers in close collaboration with Laboratory of Thermodynamics.

Particle Technology:The joint project “Integrated Development Centre for Speciality Rubber” INTEK is part of the BASF framework concept “Production for tomorrow”. Together with LANXESS, Bayer Technology Services and the university of Bonn we are developing optimal configurations for novel rubber manufacturing processes. Our own contributions concern the analysis of heat transfer processes in scraped reactors with complex phase behaviour and the micro-dispersion of low viscosity liquids in high viscosity rubber solutions. It is expected that the knowledge acquired will lead to a more intelligent

RESEARCH - POLYMER SCIENCE AND ENGINEERING

38

choice of industrial processes and equipment and considerable savings in raw materials and energy.

Chemical Process Development:The Group of Technical Chemistry A is just investigating the catalytic polymerisation of epoxides with carbon dioxide to aliphatic polycarbonates. The main objective is the optimisation of the metal catalyst, which enables both high turn over numbers and regulation of the molecular weight. Further work is planed to react lactones to polyesters. Another interesting goal is the catalytic polymerisation of renewable feedstocks.

Reaction Engineering:The activities of Group of Technical Chemistry B in the field of polymerisation research are focused on the exploitation of two phase slug flow to yield better defined conditions for polymerisation reactions than is feasible in conventional stirred tank reactors. Through mitigation of stochastic phenomena in polymerisation it is hoped that polymers with superior properties for high performance applications can be more readily synthesised. The second phase may either be inert, serving only to tighten reaction time distributions, or may function actively as a source of initiator or a sink for product or product fractions.

Thermodynamics:The Laboratory of Thermodynamics focusses on the measurement and modeling of diffusion and phase equilibria in polymer systems. To model the non-Fickian diffusion behavior in glassy polymers, the group has derived a model which combines the mass flow within the polymer with the mechanical properties of the solvent-loaded polymer. This model was applied to vapour sorption in polymers

as well as to liquid sorption in materials used for organic nanofiltration. Moreover, a new apparatus was designed that, for the first time, allows the measurement of the mechanical properties of a polymer film in a solvent atmosphere. A new modeling approach for polyelectrolyte solutions has been proposed. The influence of polymer charges and counterions on water activity as well as on aqueous two-phase systems can be predicted almost quantitatively.Finally, the thermodynamic modeling has been extended to consider the swelling/shrinking of polymer networks (hydrogels) in water.

Process Dynamics and Operations:The modeling and optimal operation of polymer production processes is one of the focal research areas of the DYN group. The goal is to develop methods that help to produce high-quality polymers in a reproducible and economically optimal fashion. Model-based state estimation, i.e. the computation of important but not measurable quantities as e.g. conversion or monomer concentration from available measurements is a tool that is used in all applications. In cooperation with BASF, the modeling and optimal operation of emulsion co-polymerisations is currently studied. In a project sponsored by the NRW CheK initiative, new control schemes for a solution polymerization at Evonik, Marl are developed. In the context of the project F3, in cooperation with BASF and Rhodia, the continuous production of co-polymers with acrylic acid is investigated experimentally. Recently, also the modeling and control of the evolution of the particle size distribution in emulsion polymerizations has been investigated.

RESEARCH - POLYMER SCIENCE AND ENGINEERING

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RESEARCH - BIOTRANSFORMATIONS

Bioprocess Development – „Biology meets Engineering“

The development of industrial biotechnological pro-cesses is characterized by interdisciplinary coopera-tion demanding considerable expertise and experi-ence from the cooperating scientists involved. This is implemented in the department by intensive net-working between research groups defining common goals and sharing scientific staff and equipment. The following projects illustrate this intradepartmental research model.

Production of Rhamnolipids as Biotensides

Rhamnolipids are interesting biotensides for indus-try and domestic use, because, besides their tenside and emulsifying characteristics, they also exhibit antimicrobial properties. Rhamnolipids are produced by Pseudomonas aeruginosa, a human pathogen bacterium, which explains why their economic pro-duction is not feasible. In a cooperation between the Blank group of the Laboratory of Chemical Biotech-nology (Schmid) and the Laboratory of Biochemical Engineering (Wichmann), the biosynthesis has been investigated and established in genetically modified strains of Pseudomonas putida. Subsequently, a bio-process of up to 150 l fermentation medium and the corresponding downstream processing was devel-oped with product recovery by foam separation and adsortion/desorption.

Bioseparations for complex culture media

The separation of compounds from complex culture media is a technical, economic, chemical and analyti-cal challenge in process engineering. To answer fun-damental questions in the field of extracting target molecules, joint projects between the Laboratory of Thermodynamics (Sadowski) and the Laboratory of Fluid Separations (Górak) have been initiated, since both laboratories share a bioextraction-laboratory, which was inaugurated in July 2011. In this labora-tory, the use of aqueous two phase systems (ATPS) is being investigated for the separation of biotechno-logically produced substances. By using two aqueous phases, the separation of the target product from the impurities can be achieved without product denatur-ation. A classical solvent system is the aqueous solu-tion of two polymers or of a polymer and a salt. Apart from this, other systems based on ionic liquids are being analyzed in common projects. These solvents, referred to as advanced fluids are used for the purifi-cation of propandiol or butanol obtained by a fermen-tation process. To survey the application of this ATPS, the fundamental phase equilibria of each system are measured and modeled using the PC-SAFT equation of state by the Laboratory of Thermodynamics. With help of this thermodynamically model, a process model will be developed in the Laboratory of Fluid Separations and validated using experimental data. These experimental data are obtained with help of a multi-stage mixer-settler apparatus, which was pur-chased specially for this project.

40

RESEARCH - BIOTRANSFORMATIONS

Whole-cell biotransformations in stable emulsions and their Down-Stream Processing (DSP) with com-pressed carbon dioxide

Whole-cell redox biocatalysis (e.g. for regiospecific oxyfunctionalizations) has become a highly attractive and easy-to-use technique for fine chemical produc-tion. Its implementation for hydrophobic compounds, which often lead to biocatalyst deactivation due to their toxicity is, typically and most easily accom-plished in organic/aqueous emulsion systems. Such two-liquid phase biotransformations face major challenges with respect to efficient and cost-effec-tive DSP. Complications mainly arise from the forma-

tion of stable emulsions due to various interfacial phenomena present in this system. In order to solve this problem, the biotransformation-related causes of emulsion stability were investigated in detail in a collaboration between the Laboratory for Chemical Biotechnology (Schmid) and the Laboratory of Thermodynamics (Sadowski). Furthermore, a novel and innovative work-up was developed using super-critical carbon dioxide (scCO2) for both phase separa-tion and product purification purposes.

41

Model-based design and operation of chemical and biochemical production processes

The development of predictive mathematical models that describe elementary physico-chemical phenom-ena, such as phase equilibria, the formation of drop-lets or the transfer of heat, mass and momentum, and composition, to models for processing units and of whole plants and the use of these models in simu-lation studies and for optimization has become the heart of the discipline of chemical engineering in the last two decades. Most research groups of the de-partment are active in this area, performing model-ling, numerical simulation and optimization on differ-ent scales from molecular to plant. A characteristic feature of the research in our department is that the work on modelling and optimization is closely related to experimental work and experimental validation. Some examples of recent activities are:

Thermodynamics: The Laboratory of Thermo-dynamics is concerned with modelling thermody-namic properties of complex substances and their mixtures with particular focus on life-science ap-plications. Over the last two to three years, an ap-proach for modelling the solubility of pharmaceutical substances in pure solvents and solvent mixtures was developed. This work is financed by the indus-trial consortium COMPOSIT, which was founded in 2008. Moreover, modelling approaches for systems containing charged components (electrolytes and polyelectrolytes) and zwitterionic substances (amino acids) were developed. Special attention was paid to accounting for the pH dependence of thermodynamic properties in these systems. The thermodynamic in-vestigation of compatible solutes (osmolytes) helps to explain the biological impact of these substances.

RESEARCH - MODELING

Fluid Mechanics: Dispersed gas bubbles play an important role in distillation, extraction, and hetero-geneous catalysis. The bubble-size distribution and the rising velocity determine both, interfacial area and residence time, the two most important para-meters for heat and mass transfer. The influence of contaminants, adsorbed on the surface of small air bubbles, rising in water, is being examined by numeri-cal simulations. From these investigations, we are able to resolve an open question on why, for example, gas bubbles in water rise much slower than predicted theoretically.

Fluid Separations: In the Laboratory of Fluid Separations a family of mathematical models of reactive and hybrid separation processes of various

Rising velocity of air bubbles in water, various correlations and present simulations. The parameter E characterizes the strength of the contamination.

complexities have been developed. In current work, a nonequilibrium-stage model was successfully applied to design a pilot-scale reactive distillation column for multiple-product operation. Experiments show that high selectivity can be achieved for each product by changing the operating conditions of the column. For the first time, the potential of a reactive distillation column to act as a multi-purpose reactor was demonstrated experimentally.

42

RESEARCH - MODELING

Equipment Design: The Laboratory of Equip-ment Design started the investigation of carrying out in-tensified mixing processes in microchannels and microstructured devices. These devices provide an ideal process space for chemical and biochemical transformations under optimal conditions. Single and multiphase flow processes are investigated by nume-rical and experimental analysis to yield a consistent description and methodology for efficient scale-up from laboratory studies to production scale. Modular reactor and separation devices are being developed, fabricated, and tested together with academic and industrial partners.

Process Dynamics and Operations: The Process Dynamics and Operations Group has been developing methods for the systematic model-based selection of control structures in complex units of chemical plants. The key idea is to base the selection of control structures on the comparison of the operating per-formance of the unit in the presence of disturbances, employing a rigorous plant model. As the number of possible structures can be very large, system-theore-tical tools are first employed in a pre-screening step. The stationary performance of the remaining struc-tures is then compared, and for the most promising

Product selectivity as a function of time between two steady-state operating points.

structures, the dynamic rejection of disturbances is also taken into account. Recently, this method has been applied to two integrated processes that are being developed in the EU-funded Integrated Project F – Fast Flexible Future Factory.

In recent years, in addition to the use of models for exploration and for the validation of designs by simu-lation, model-based optimization has been increasin-gly applied to compute optimal plant configurations and optimal operating regimes and production sche-dules. Several groups use evolutionary algorithms in the optimization of plant designs (e.g. membrane reactors, reactive absorption and reactive distillation) and also basic research on so-called mimetic algo-rithms (algorithms that integrate evolutionary and mathematical optimization) is being performed in the department by the Process Dynamics and Opera-tions Group. The new algorithm can determine a large number of local optima in design problems in a very efficient manner.

Different local optima for the design of a reactive distillation column with side-reactor for the productin of MTBE, leading to almost identical annual profits

43

RESEARCH - HIGHLIGHTS

SFB InPrompt - Transregio

The Department BCI is part of a research initiative called INPROMPT. This research program involves about 20 research groups from three universities: TU Berlin and TU Dortmund and Universität Magdeburg. It is funded by the German Science Foundation for four years with the possibility of an extension. BCI research groups are funded to the tune of about 2 Mio € for 2010 until 2013. INPROMPT stands for “Integrated Chemical Proces-ses in Liquid Multiphase Systems“. The objective of this collaborative research initiative is the develop-ment of efficient production processes which involve liquid multiphase systems during reaction and/or product work up.

The process development is being carried out for the hydroformylation of long-chain olefins using Rhodi-um catalysts as a model reaction. The rhodium cata-lyst is soluble in very polar media only, which causes a phase separation into an unpolar educt-rich phase and the polar catalyst phase. The main idea of the project is to induce mixing of these two phases under reaction conditions by applying thermomorphic or micellar solvent systems. After reaction, however, phase splitting is induced by a temperature change or by separation of the micelles resulting in an al-most complete recovery of the catalyst.

Research groups of the department are involved with the following sub-tasks:

Chemical Process Development (Prof. Behr):

- Rhodium-complex Catalyzed Hydroformylation with Temperature-Controlled Catalyst Separa- tion in Gas/Liquid/Liquid-Systems- Design, Construction and Start-up of a Miniplant for the Hydroformylation of Long-chain Alkenes in Thermomorphic Solvent Systems

Thermodynamics (Prof. Sadowski):

- Phase Equilibria and Interfacial Properties of Complex Mixtures

Thermodynamics (Dr. Ruether) & Fluid Separations (Prof. Górak):

- Hybrid Separation Processes for Purification of Wide and Close Boiling Mixtures in the Hydrofor- mylation of Long-chained Olefins

Plant and Process Design (Prof. Schembecker) &Process Dynamics and Operations (Prof. Engell):

- Model-based Management of the Development of Novel Chemical Production Processes

For process development, a combined bottom-up-analysis and a top-down-solution are combined. The bottom-up-approach is based on the reaction and leads to a proposed overall process. The top-down-solution approach derives requirements for individu-al process steps from all possible process variants. Consequently, not only the reaction step but the entire process chain from raw material to the pure

44

RESEARCH - HIGHLIGHTS

product is considered to attain an integral and rapid process development. With this integrated process development in mind, the following methods for

– precise identification of the kinetic and thermo- dynamic properties,– optimal design of the unit operations for reaction and separation,– and accelerated process development and optimisation

are developed.

The Transregional Collaborative Research Centre strives to open the door for the technical implemen-tation of a new class of chemical production proces-ses. The above mentioned methodological studies are carried out using the hydroformylation of long-chain olefins with the use of thermomorphic or micellar

solvent systems as a model reaction. The Transre-gional Collaborative Research Centre is divided into three clusters of projects that apply and develop experimental and theoretical methods from the disciplines of chemical engineering, thermodynamics and process- and systems engineering. In cluster A, the chemo-physical phenomena of representative substrate systems are studied. Based on this, cluster B investigates individual process steps and partial sequences of chemical reactions and separation processes. Cluster C develops methods and tools for process modeling and optimization.

In the TR/SFB, more than 60 scientists from diffe-rent universities and institutions such as Technische Universität Berlin, TU Dortmund, Otto-von-Guericke-Universität Magdeburg, ETH Zürich and Max-Planck-Institut für Dynamik komplexer technischer Systeme are involved.

Prof. Arno Behr, Prof. Sebastian Engell, Dr. Feelly Rüther, Prof. Gabriele Sadowski und Prof. Andrzej Górak

45

RESEARCH - HIGHLIGHTS

INVITE, Cooperation of Bayer and TU Dortmund

In the spring of 2010, Bayer Technology Services (BTS) and TU Dortmund have established the INVITE GmbH research company, which operates a new research center at Chempark Leverkusen, Germany. The new building is partly funded by 5 Mio Euro from the state North Rhine-Westphalia and is officially opened on September 21st, 2011. This “factory of the future” will provide the framework to develop and test modern, flexible and efficient production con-cepts that help to improve production processes and conserve resources. The open research center INVITE stands for INnovations, VIsions, and TEchnology. INVITE is intended not only to develop innovative

reaction and process technologies with the help of process intensification, microreactor technology and modular, standardized fabrication units, but INVITE should also serve as an open platform for all stakeholders involved to develop their own efficient production technologies. The building can host three standard shipping containers filled with modular chemical equipment for testing and has also labo-ratory and lecture room capacities. Besides a EU project on modern production concepts (F , Flexible, Fast, Future), INVITE is hosting MoBiDiK on modular bio-production and CO2RRECT on the chemical use of CO2 to manufacture innovative materials. Results from the research projects will also be disseminated to students in their education programs as well as to working professionals in advanced training programs.

On October 4th, 2010, Svenja Schulze, minister of research in North Rhine-Westphalia visited the Leverkusen site and was informed about the planning and progress of INVITE by Prof. Metin Tolan, TU Dortmund, Dr. Michael Lorenz, CEO INVITE GmbH, Dr. Wolfgang Plischke, Bayer management board mem-ber, and Dr. Dirk Van Meirvenne, CEO BTS.

46

RESEARCH - HIGHLIGHTS

F Factory

F Factory is a 30 Mio € collabora-tive research programme that seeks to strengthen the European chemi-cal industry’s global technological leadership through faster, more flexible production methods. It is one of the leading projects in the re-

search priority of the European Community’s Seventh Framework programme. The F Factory consortium comprises 25 leading companies and research insti-tutions from nine EU Member states that are cross-ing competitive boundaries to collaborate on new technologies for process intensification and innova-tive new production concepts.

Specific objectives of the project are:

to deliver radically new ‘plug and play’ modular chemical production technology, capable of widespread implementation throughout the chemical industry

to design and develop a modular continuous plant (the F Factory ‘backbone’ plant in Leverkusen)

to standardise processes and their interfaces by developing methodologies for entire process design focussed on modular plant.

Four Laboratories of our department are involved in the project. We focus on:

the “green route” for producing acrylates in a heterogenously catalysed reactive distillation column

a decision support tool to select the most eco- nomic production method

the continuous production of co-polymers of acrylic acid in intensified reactors

the control and operation of flexible intensified processing plants.

47

RESEARCH - HIGHLIGHTS

Cluster Industrial Biotechnology CLIB2021

Members of the CLIB-Graduate Cluster during the 2nd Annual Retreat in Bonn, March 2011

Founded in March 2007, today CLIB2021 is the leading German Cluster in industrial biotech-nology. Its more than 80 members comprise large chemical and pharmaceutical companies, small and medium enterprises, investors, infrastructure and academia. The cluster initiates cooperative projects in research and development between the partners. Currently projects with a total volume and 44 Mio € worth of are ongoing, for another 25 Mio € new projects are under review.The Department of Biochemical and Chemical Engineering of TU Dortmund plays a major role in this cluster, since it acts as cooperation partner in several

48

collaborative research projects and hosts the two technology platforms ‘Biocatalysis’ and ‘Downstream Processing’. In these CLIB-projects, 26 PhD students and 3 post docs are performing research in the field of new biocatalytic routes to intermediate products, sustainable chemistry utilizing renewable carbon sources, the development of new reactor formats, systematic process synthesis procedures, simulation of bioprocesses, and innovative downstream processes, like foam fractionation, centrifugal partition chromatography or crystallization.To strengthen the fundamental research in CLIB2021, in 2009 the CLIB Graduate Cluster started as a joint post-graduate school of TU Dortmund and the uni-versities of Bielefeld and Düsseldorf. The programme supports 84 young scientists to perform research torwards a doctoral degree on the highest interna-tional level. Currently, 25 scholarship holders are working on their doctoral theses in the Department of Biochemical and Chemical Engineering with 7 labora-tories being involved. Their topics cover a wide range of research questions from the development of new biocatalysts, continuous fermentation processes, physical property prediction of complex mixtures, to the use of ionic liquids and aqueous two phase sys-tems for product removal.

RESEARCH - HIGHLIGHTS

ChemBioTec – Network for sustainable chemical and biotechnological production processes

ChemBioTec is funded by the Deutsche Bundesstif-tung Umwelt (DBU) and the Department of Bioche-mical and Chemical Engineering at the TU Dortmund and is working in the field of industrial biotechnology. Its aim is the implementation of new, sustainable biotechnological production processes in the che-mical, pharmaceutical and in related industries. In the long run the aim is to realise, an interdisciplinary research and development network in Germany, that comprises both an academic as well as industrial institutions.A particular emphasis is placed on the integration of chemical, biotechnological and downstream proces-sing research. In this context, innovative products and technologies are being established by German companies and research institutions in the field of „environmentally-friendly (Bio) Catalysis”.

49

RESEARCH - HIGHLIGHTS

ChemBioTec goals:

Monitoring of application procedures for project funding in the field of sustainable bioproduction processes (over 36 months, with about 47 % support for research and small and medium- sized enterprises [SMEs])

Development of regional and national compe- tence networks (science/industry)

Creating a knowledge-based Internet platform for the exchange of know-how, product ideas and project partners

Help and assistance in product development along the value chain

Supportive measures in the field of education and training

Currently ChemBioTec supports 26 projects with more than 90 Partners from academia and industry (large and small and medium-sized enterprises), the total budget is more than 23 Mio €.

BioTrends 2010 - New Biotrends in Green Chemistry - Dortmund , December 1st-2nd, 2010

50

RESEARCH - NETWORK

Networking of the Laboratories

The Department of Biochemical and Chemical Engi-neering is engaged in several national and internatio-nal (research-) projects and is in contact with resear-chers all over the world.There is also a strong cooperation between the labora-tories of the department. There are several projects in which three or more laboratories are working together as indicated by the fi gure above.

51

RESEARCH - THE EUROPEAN PROJECT OFFICE

The European Project Office

The European Project Office resulted from an initia-tive of the Department of Biochemical and Chemical Engineering. The unit founded in 2010 offers project management services to all researchers of Techni-sche Universität Dortmund, especially with regard to planning and executing cooperation projects within the 7th Framework Programme of the European Commission, where the management effort of inter-national interdisciplinary consortia is high. The idea was stimulated by the daily experience with project work. Over the course of time, it became evident that employing additional staff with mana-gerial expertise, complementing the research excel-lence of the faculty, was necessary. Going one step

further and clustering projects by placing repetitive managerial tasks in the hands of a permanent team for several projects with different research themes allows the efficient use of staff, since parallel work on solving similar problems is no longer necessary. The team members gain experience more quickly and retain it beyond the duration and budget constraints of a single project.

“The experience gathered from past and current pro-jects can be retained, developed and further applied to face further challenges more efficiently”, says Dorota Pawlucka, the leader of the office.

Services provided by the European Project Office

52

RESEARCH - THE EUROPEAN PROJECT OFFICE

Currently, the team consists of four empoyees who possess the complementary skills and coordinate eight projects, assuming tasks such as communi-cation, organization, controlling and counseling. It also acts as an interface between the university’s administration, the project partners, the European Commission and the National Contact Points, thus offering a one-stop shop for the researchers.

“We understand our role as that of a science support service: Thanks to this service, the researcher has his hands free to devote himself fully to science and teaching, without even noticing all the burdens of organization and administration that arise”, explains Dorota Pawlucka. As a part of the EPORR project (European Project Office Rhein-Ruhr) in cooperation with the University of Duisburg-Essen, the EU project office is sponsored by the Ministry of Innovation, Science and Research of North Rhine-Westphalia.

The European Project Office

53

July 2009 - June 2011

Chemical Biotechnology (BT)

Dr. rer. nat. Reto Ruinatscha„Asymmetric biocatalytic epoxidation in a scalable electrochemical reactor using FAD-dependent sty-rene monooxygenase”

Dr.-Ing. Hendrik Kortmann„The Envirostat: A Lab-on-a-Chip Reactor Concept for Single Cell Biotechnology”

Dr. rer. nat. Rainer Gross„Catalytic Biofilms in Membrane Reactors: Continu-ous Asymmetric Epoxidation of Styrene and Regiose-lective Hydroxylation of Alkanes“

Dr. rer. nat. Sasidhar Maddula„Cell cycle phase metabolism of colon cancer cells: a metabolome study”

Dr. rer. nat. Jan Heyland„ -Aminopeptidases: Recombinant production and cell based biocatalysis”

Chemical Process Development (TCA)

Dr.-Ing. Martin Halama„High-Throughput-Sreening homogen katalysierter Hydrierungen im kontiniuerlich durchströmten Membranreaktor”

Dr.-Ing. Thomas Beckmann„Mehrphasige Telomerisation im Labor- und Miniplantmaßstab”

Dr. rer. nat. Sebastian Reyer„Katalytische Funktionalisierungen des Isoprens - Wertprodukte aus Basischemikalien”

Dr.-Ing. Marc Becker„Der Strahlschlaufenreaktor als alternatives Reak-torkonzept für homogen katalysierte Mehrphasen-reaktionen am Beispiel der Hydroaminomethylierung”

Dr.-Ing. Falk Lindner„Katalysator- und Verfahrensentwicklung der heterogen katalysierten Glycerinoligomerisierung”

Environmental Technology (UT)

Dr.-Ing. Tobias Nöthe„Zur Ozonung von Spurenstoffen in mechanisch-biologisch gereinigten Abwässern”

Dr.-Ing. Frank Radon„Über Untersuchungsmethoden als Beitrag zu einer verbesserten Abfallwirtschaftung in lateinamerika-nischen Schwellenländern”

Dr.-Ing. Alexander Kroll„Modellierung und Simulation der SO2-Reaktivad-sorption an Wassertropfen mittels CFD zur rigorosen Berechnung effektiver Stoffdurchgangskoeffizienten”

Dr.-Ing. Vanessa Kubacz„Vereinfachtes Modell zur Bewertung der Leistungs-fähigkeit von Aminen und deren Mischungen bei der Entfernung von CO2 aus Kraftwerksrauchgas”

FACTS & FIGURES - DOCTORAL DEGREES

54

FACTS & FIGURES - DOCTORAL DEGREES

Dr.-Ing. Bernhard Epp„Grundlegende Untersuchungen zum Absorptions- prozess bei der Dekarbonisierung von Rauchgasen mit Membrankontaktoren”

Dr.-Ing. Christina Stankewitz„Analyse zur verbesserten energetischen Integration einer Postcombustion Carbon Capture Wäsche in den Kraftwerksprozess”

Fluid Mechanics (SM)

Dr.-Ing. Brain Stöver„Experimentelle und numerische Betrachtung der Vorgänge bei der Demineralisierung eines festen Energieträgers”

Dr.-Ing. Peter Lakshmanan„Gas bubbles in pure and contaminated liquids”

Fluid Separations (FVT)

Dr.-Ing. Constantin Frerick„Rigorous Modelling, Simulation and Evolutionary Optimisation of Generic Protein Downstream Processes”

Dr.-Ing. Sebastian Lauterbach„Membranunterstützte Reaktions- und Trenn-prozesse - Scale-up und Prozessanalyse”

Dr.-Ing. Jan Mackowiak„Direktkondensation und Desorption von reaktiven Mehrkomponentengemischen in Packungskolonnen”

Particle Technology (MV)

Dr.-Ing. Rafael Grochowski„Behavior of Granular Material on an Vibrating Conveyor”

Dr.-Ing. Sven Bensmann„Zu Misch- und Transportprozessen granularer Median in kontinuierlich betriebenen Drehrohren”

Plant and Process Design (APT)

Dr.-Ing. Christian Bramsiepe„Beitrag zur Modellierung diffuser Emissionen an flüssig beaufschlagten Flanschverbindungen mit Graphitdichtungen”

Process Dynamics and Operations (DYN)

Dr.-Ing. Tanet Wonghong„Adaptation by Evolutionary Algorithms in Unfalsified Control”

Dr.-Ing. Achim Küpper„Optimization, State Estimation and Model Predictive Control of Simulated Moving Bed Processes”

Dr.-Ing. Wolfgang Mauntz„A Contribution to Observation and Time-optimal Control of Emulsion Co-Polymerization Reactions”

Dr.-Ing. Jian Cui „Medium-term Planning of a Multi-product Batch Plant under Multi-period Multi-uncertainty by Two-stage Stochastic Programming”

55

Dr.-Ing. Thomas Tometzki„Hybrid Evolutionary Algorithms for Efficient Solution of Planning Problems under Uncertainty”

Reaction Engineering (TCB)

Dr.-Ing. Sven Reßler„Selektivitätslenkung in multifunktionalen adsorptiven Reaktoren”

Dr.-Ing. Sebastian Lohse„Experimentelle Bestimmung der Verweilzeit-verteilung in Mikroreaktoren”

Dr.-Ing. Ivo Müller„Theoretische Untersuchung innovativer integrierter Trennverfahren”

Dr.-Ing. Yudy Halim Tan„Study of CO2-Absorption into Thermomorphic Lipophilic Amine Solvents”

Dr.-Ing. Manuel Nau„Desorptive Kühlung chemischer Reaktoren: Untersuchungen zur Selektivitätssteigerung und Maßstabsvergrößerung”

Dr.-Ing. Aras Ghaini„Untersuchung der flüssig-flüssig Pfropfen-strömung im Kapillar-Mikroreaktor zur Intensivierung stofftransportlimitierter Reaktionen”

FACTS & FIGURES - PHDS

Technical Biochemistry (TB)

Dr.-Ing. Yue Xuan„Investigation of the functional diversity of the low-molecular-weight metal species in plants”

Dr.-Ing. Christiana Borrelli„Imprinted Polymers Targeting Phosphoryladed Peptides and Engineering Functionalised Mem-branes for Selective Recognition of Riboflavin”

Thermodynamics (TH)

Dr.-Ing. Jan Fischer„Molecular Modeling of Complex Systems for Applications in Thermodynamics”

Dr.-Ing. Matthias Funke„Analyse von Verbesserungpotentialen der Gaserzeugung eines PEMFC-Hausenergiesystems”

ISAS

Dr. rer. nat. Arunachalam Venkatachalam„ICP-MS based analytical screening of phosphorylated and labelled proteins”

56

FACTS & FIGURES - PUBLICATIONS

Total Number of Publications

For details see page 68 pp

57

FACTS & FIGURES - GRADUATES AND THESES

Total Number of Diploma Graduates and Master Graduates

Number of Diploma-, Bachelor- and Master Theses in the different Laboratories

58

Chemical Biotechnology (BT)

Schmid, A., Karande, R., Buehler, K.: Segmented Flow Biofilm Reactor, (2011) PCT/EP2011/057724, filed.

Buehler, B., Julsing, M. K., Schmid, A., Schrewe M., Cornelissen S.:Biokatalytisches Oxidationsver-fahren mit alkL-Genprodukt, Germany, (2010), DE 102010015807.0, filed.

Karau, A., Sieber, V., Haas, T., Häger H., Grammann, K., Buehler, B., Blank, L. M., Schmid, A.: omega-amino carboxylic acids, omega-amino carboxylic acid es-ters, or recombinant cells which produce lactams thereof, (2009), WO/2009/077461.

Chemical Process Development (TCA)

Behr, A., Kleyensteiber, A.: Verfahren zur kontinuierlichen Herstellung von Glycerintertiärbutylethern, DE102009055928, 27.11.2009.

Behr, A., Perez Gomes, J., Krema, St.: Verfahren zur Herstellung von Dicarbonsäuren oder Dicarbon-säureestern durch Metathese, DE102010010984, 10.03.2010.

Behr, A., Johnen, L., Bastian, D.: Verfahren zum Recycling von Biokatalysatoren, EP2010/004357, 16.07.2010.

Behr, A., Kleyensteiber, A.: Verfahren zur kontinuierli-chen Herstellung von Glycerintertiärbutylethern, EP 2010/068294, 26.11.2010.

Fluid Separations (FVT)

Górak, A., Kreis, P.,van Beijeren, P., Faber, R., Demmer, W., Frerick, C.: Device and method for material sepa-ration, WO 2010/083859, 2010.

Pitner, W.-R., Schulte, M., Górak, A., Santangelo, F., Wentink, A.E.: Use of ionic liquids with tetracyanobo-rate anions as a solvent for extraction of alcohols from aqueous solutions, WO 2009/152906, 2009.

Plant and Process Design (APT)

Schembecker, G., Winkelnkemper,T. : Prozess zur grosstechnischen Produktion von Taxanen, DE 10 2008 031 208 B4 (2010).

Schembecker, G., Burghoff, B., van Winssen, F. A.: Verfahren zur Trennung/Reinigung von Biomolekülen, AZ 10 2011 001 743.7, applied April 1st, 2011.

FACTS & FIGURES - PATENTS

59

FACTS & FIGURES - STAFF

Age Distribution of the Scientific Staff with-out the Professors in 2011

Age Distribution of the Technical Staff in 2011

Age Distribution of the Professors in 2011Staff (Person Years)

Total 124.0 229.5

Technical Staff 67.5 10.5 78

Scientific Staff 42.5 95 137.5

Professors 14 0 14

Budget Third Party Funds Total

105.5

60

Students from Abroad in %

Female Students in %

FACTS & FIGURES - STUDENTS

New and First Enrolments

Overall Number of Students

61

Duration of Studies in SemestersDiploma (Median)Chemical Engineering (CE)Biochemical Engineering (BE)

Duration of Studies in SemestersMasters (Median)Chemical Engineering

FACTS & FIGURES - STUDENTS

62

Third-Party Funds 2010

Development of the University Budget in Mio €, 2008 - 2010

Development of Third-Party Fundsin Mio €, 2006 - 2010

The Department of Biochemical and Chemical Engi-neering has funds from the following sources at its disposal:

University Budget Third-Party Funds Tuition Fees (page 64)

FACTS & FIGURES - FINANCES

63

Use of Tuition Fees

Since tuition fees were introduced in North Rhine- Westphalia in 2007, the department has benefited from these new funds to improve study conditions. At the beginning of each year, these funds are allo-cated in collaboration with the student representa-tives. At the end of the financial year, representatives of the students’ council check whether they have been used according to the plan through site inspec-tions.

Spending of Tuition Fees 2009Sum: 399,477 EUR

FACTS & FIGURES - TUITION FEES

64

Spending of Tuition Fees 2010Sum: 313,056 EUR

Spending of Tuition Fees 2011(planned)Sum: 411,000 EUR

FACTS & FIGURES - TUITION FEES

65

FACTS & FIGURES - INFRASTRUCTURE

To fulfill its research and teaching tasks, the Department of Biochemical and Chemical Engineer-ing has a good infrastructure at its disposal.

AreasOffices 3,140 m

Laboratories 2,890 m

Pilot plants 2,700 m

Seminar rooms 1,020 m

Workshops 1,700 m

Student labs 930 m

Storage 1,840 m

Other 410 m

Total 14,630 m

Common service units The common service serve all groups of the depart-ment. They advise and support the research groups, in the planning of experimental set-ups and fabricate individual components or complete equipment items for research projects. Their long-standing experience and direct contact with the scientists ensure that they can react immediately to the demands of the in-dividual research groups.

Electronic WorkshopCustomised automation and programming solutions. Acquisition, design, maintenance, and repair of elec-tronic equipment and components.

Electromechanical WorkshopDesign and construction of electrical equipment and sub-assemblies; acquisition and repair of all electri-cal and electromechanical equipment.

Media LabProfessional digital photographs of staff, events, and equipment, digital image processing. Design and processing of print media.

Glass WorkshopAcquisition and fulfilling special orders for all glass components. Mechanical WorkshopCustomised development, construction, and repair of metal, glass, and plastic components ranging from the smallest precision-made components to set-ups that weigh tons. Computer Operations GroupInstallation, support and maintenance of the entire IT structure; advice and acquisition of hard- and soft-ware.

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FACTS & FIGURES - INTERNATIONAL EXCHANGE

Hong Kong University of Science and Technology, China

TU Lappeenranta, Finland

INSA, Rouen, FranceINP, Toulouse, France

Kyoto University, Japan

TU Twente, The NetherlandsDelft University, The NetherlandsTU Eindhoven, The Netherlands

Universidad Rey Juan Carlos Madrid, SpainUniversidad de Valladolid, Spain

KTH, Stockholm, SwedenUniversity of Lund, Sweden

Universidade de Aveiro, Portugal

Yildiz Teknik Üniversitesi, TurkeyAnkara Üniversitesi, Turkey

University of Newcastle, UK

Carnegie Mellon University, USALehigh University, USAUniversity of Pennsylvania, USAPrinceton University, USA

Technische Universität Graz, Austria

Poznan University of Medical Science, PolandTechnical University of Lodz, Poland

DTU Lyngby, Denmark

Université de Liége, Belgium

University of Osijek, Hungary

TU Brnê, Brno, Czech Republic

Zürcher Hochschule fürAngewandte Wissenschaften, Switzerland

Student and teaching staff exchange

UFRGS Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil

67

FACTS & FIGURES - PUBLICATIONS

Laboratory of Biochemical Engineering (BVT)

Zabor, S.; Nowacki, C.; del Amor Villa, E.-M.; Müller, H.: ”Di-rect Ethanol Determination”, G.I.T. BIOprocessing, 14, (2010), 34-35

del Amor Villa, E.-M.: ”Continuous bio-ethanol production by means of yeast”; BlueSens Report, 1, (2010) 10-11

Laboratory of Biomaterials and Polymer Sciences (BMP)

Fik, C.P.; Meuris, M.; Salz, U.; Bock, T.;Tiller, J.C.: ”Ultrahigh-Aspect Ratio Microfiber-Furs as Plant-Surface Mimics Derived from Teeth”, Advanced Materials 23, DOI: 10.1002/adma.201101102 (2011)

v. Czarnecki, P.; Kampert, A.; Barbe, S.; Tiller, J.C.: “Bifunc-tional Aryloxalate Esters as Potential Oxidatively Cleavable Linkers”, Tetrahedron Letters 52 (28), (2011) 3551-3554

Katzenberg, F.; Heuwers, B.; Tiller, J. C.: “Superheated Rubber for Cold-Storage”; Advanced Materials 23, (2011) 1909–1911

Tiller, J. C.: “Antimicrobial Surfaces“. in:Bioactive Surface, Advances in Polymer Science, Band 240, (2011) 193-217

Dech, S.; Cramer, T.; Ladisch, R.; Bruns, N.; Tiller, J. C.: “Solid-solid interface adsorption of proteins and enzymes in nanophase-separated amphiphilic conetworks“, Biomacro-molecules 12 (5), (2011) 1594–1601

Tobis, J.; Boch, L.; Thomann, Y.; Tiller, J. C.: “Amphiphilic poly-mer conetworks as chiral separation membranes”, Journal of Membrane Science 372, (2011) 219-227

Fik, C. P.; Konieczny, S.; Krumm, C.; Schönfeld, I.; Tiller, J. C.: “Telechelic Poly(oxazoline)s for Bioactive Conjugates”, Mac-romolecular Rapid Communications 32 (2), (2011) F73-F74

Bieser, A. M.; Tiller, J. C.: “Mechanistic Considerations on Contact-Active Antimicrobial Surfaces with Controlled Functional Group Densities”, Macromolecular Bioscience 11(4) (2011) 526-534

Bieser, A. M.; Thomann, Y.; Tiller, J. C.: “Contact-Aktive Anti-mikrobial and Potentially Self-Polishing Coatings Based on Cellulose”, Macromolecular Bioscience 11, (2011) F73-F74

Mendorf, M.; Moenter, A.; Moll, T.; Agar, D. W.; Tiller, J. C.: “Polymerisation of Butyl Acrylate in the two phase slug flow regime of parallel microcapillary reactors”, Macromo-lecular Symposia, DOI: 10.1002/masy.201000067 (2010)

Mueller, F.; Heuwers, B.; Katzenberg, F.; Tiller, J. C.; Sadows-ki, G.: “Tensile Creep Measurements of glassy VOC-loaded Polymers”, Macromolecules 43, (2010) 8997-9003

Tobis, J.; Thomann, Y.; J. C. Tiller, J. C.: “Synthesis and cha-racterization of chiral and thermo responsive amphiphilic conetworks”, Polymer 51, (2010) 35-45

Tiller, J. C.; Ho, C. H.: “Hyperbranched polylysine-synthesis, characterization and applications”, Polym. Mater. Sci. Eng 239, (2010) 13965-13966

Schaup, J.; Katzenberg, F.: ”Phase diagram of PMMA/PVDF-blends and effect of mixture-intensity on crystallization behaviour”, Polym. Mater. Sci. Eng 239, (2010) 5951-5952

Bruns,N.; Hanko, M.; Dech, S.; Ladisch, R.; Tobis, J.; Tiller, J. C.: “Amphiphilic Polymer Conetworks as Matrices for Phase Transfer Reactions”, Macromolecular Symposia 291-292, (2010) 293-301

Hadjiantoniou, N. A.; Patrickios, C. S.; Thomann, Y.; Tiller, J. C.: “Amphiphilic Conetworks Based on End-Linked Multi-block Copolymers of Different Numbers of Blocks and Con-stant Molecular Weight and Composition”, Macromolecular Chemistry and Physics 210, (2009) 942-950

Barbosa, A. P.; Stranz, M.; Katzenberg, F. et. al.: “Cryogenic mechanical milling of high density polyethylene”, e-Poly-mers 096 (2009)

68

Laboratory of Chemical Biotechnology (BT)

Books & Bookchapters

Brandenbusch, C.; Buehler, B.; Sadowski, G.; Schmid, A.: “Bio-katalytische Epoxidierung von Styrol zu enantiomer-enreinem (S)-Styroloxid“, in Chmiel H. Bioprozesstechnik, Spektrum Akademischer Verlag, Heidelberg, (2011), Ger-many:486-488, ISBN: 978-3-8274-2476-1

Hollmann, F.; Buehler, K.; Buehler, B.: “Oxidation of Alcohols, Aldehydes and Acids”, in Drauz, K., Gröger, H., May, O. En-zyme Catalysis in Organic Synthesis, Wiley-VCH, Weinheim, (2011), Germany

Buehler, B.; Buehler, K.; Hollmann, F.: “Oxyfunctionalization of C-C-Multiple Bonds”, in Drauz, K., Gröger, H., May, O. En-zyme Catalysis in Organic Synthesis, Wiley-VCH, Weinheim, (2011), Germany

Ütkür, F. Ö.; Schmid, A.; Buehler, B.: “Regioselective Aromatic Hydroxylation of Quinaldine Using Living Pseudomonas putida Cells Containing Quinaldine 4-oxidase”, in John Whitthal and Peter Sutton Practical Methods in Biocataly-sis and Biotransformations, John Wiley & Sons Ltd, (2011); Chichester, UK

Blank, L. M.: Habilitation Thesis: “Systems Biotechnology & Biocatalysis”, TU Dortmund; (2010), Dortmund, Germany

Buehler, K.; Schmid, A.: “Biopetrochemicals via biocatalysis by hydrocarbon microbes and their enzymes“, in Kenneth Timmis Handbook of Hydrocarbon and Lipid Microbiology.Springer, (2009), Berlin, Germany, Vol. 1, ISBN: 3540775889

Buehler, B.; Blank, L. M.; Ebert, B. E.; Buehler, K.; Schmid, A.: “Energy and cofactor issues in fermentation and oxy-functionalisation processes”, in Smolke C. D. The metabolic pathway engineering handbook, CRC Press, Boca Raton, Florida, USA, Vol. 2:21 1-32, ISBN: 978-1-4200-7765-0

Buehler, K.; Schmid, A.: “Synthesis of enantiopure (S)-sty-rene oxide by selective oxidation of styrene by recombinant E. coli”, in John Witthall and Peter Sutton Practical Methods in Biocatalysis and Biotransformations, John Wiley & Sons Ltd, Chichester, UK:385-390, ISBN: 978-0-470-51927-1

Peer Reviewed Articles

Halan, B.; Schmid, A.; Buehler, K.: “Real time solvent tolerance analysis of Pseudomonas sp. strain VLB120 C catalytic bio-films”, Applied and Enviromental Microbiology, 77(5), (2011), 1563-1571

Heyland, J.; Fu, J.; Blank, L. M.; Schmid, A.: “Carbon metabolism limits recombinant protein production in Pichia pastoris”, Bio-technology and Bioengineering, (2011), DOI: 10.1002/bit.23114

Cornelissen, S.; Liu, S; Deshmukh, A. T.; Schmid, A.; Buehler, B.: ”Cell physiology can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization”, Journal of Indus-trial Microbiology and Biotechnology, (2011), DOI: 10.1007/s10295-010-0919-y

Hollmann, F.; Arends, I. W. C. E.; Buehler, K.; Schallmey, A.; Buehler, B.: “Enzyme-mediated oxidations for the chemist”, Green Chemistry, 13, (2011), 226-265

Kortmann, H.; Blank, L. M.; Schmid, A.: “Single cell analytics: an overview”, Advances in Biochemical Engineering and Biotech-nology, 124, (2011), 99-122

Fritzsch, F.; Kortmann, H.; Lonzynski, J.; Blank, L. M.; Schmid, A.: “Pressure resistant and reversible on-tube-sealing for microfluidics”, Microfluidics and Nanofluidics, 10(3), (2011), 679-684

Ütkür, F. Ö.; Gaykawad, S.; Buehler, B.; Schmid, A.: “Regioselec-tive aromatic hydroxylation of quinaldine with water using quinaldine 4-oxidase in recombinant Pseudomonas putida”, Journal of Industrial Microbiology and Biotechnology, (2010), DOI: 10.1007/s10295-010-0883-6

FACTS & FIGURES - PUBLICATIONS

69

FACTS & FIGURES - PUBLICATIONS

Hollmann, F.; Arends, I. W. C. E.; Buehler, K.: “Biocatalytic redox reactions for Organic Synthesis: Nonconventional re-generation methods”, ChemCatChem; 2(7), (2010), 762-782

Gross, R.; Lang, K.; Buehler, K.; Schmid, A.: “Characterization of a biofilm membrane reactor and its prospects for fine chemical synthesis”, Biotechnology and Bioengineering, 105(4), (2010), 705-717

Vickers, C. E.; Blank, L. M.; Krömer, J. O.: “Chassis cells for industrial biochemical production”, Nature Chemical Bio-logy (Grand Challenge), 6(12), (2010), 875-877

Schmid, A.; Kortmann, H.; Dittrich, P.; Blank L. M.: “Chemical and biological single cell analysis”, Current Opinion in Bio-technology, 21(1), (2010), 12-20

Brandenbusch, C.; Buehler, B.; Hoffmann, P.; Sadowski, G.; Schmid, A.: “Efficient phase separation and recovery in organic-aqueous bioprocessing using supercritical carbon dioxide”, Biotechnology and Bioengineering, 107(4), (2010), 642-651

Karande, R.; Schmid, A.; Buehler, K.: “Enzyme catalysis in an aqueous/organic segment flow microreactor: ways to stabi-lize enzyme activity”, Langmuir, 26(11), (2010), 9152-9159

Gardossi, L; Poulsen, P. B.; Ballesteros, A.; Hult, K.; vedas, V. K.; Vasi -Ra ki, .; Carrea, G.; Magnusson, A.; Schmid, A.; Wohlgemuth, R.; Halling, P. J.: “Guidelines for reporting of biocatalytic reactions”, Trends in Biotechnology, 28(4), (2010), 171-180

Kuhn, D.; Kholiq, A.; Heinzle, E.; Buehler, B.; Schmid, A.: “In-tensification and economic and ecological assessment of a biocatalytic oxyfunctionalization process”, Green Chemistry, 12(5), (2010), 815-827

Heck, T.; Makam, S.; Lutz, J.; Blank, L. M.; Schmid, A.; See-bach, Dieter; Kohler, H.-P. E.; Geueke, B.: “Kinetic analysis of L-carnosine formation by beta-aminopeptidases”, Ad-vanced Synthesis and Catalysis, 352(2-3), (2010), 407-415

Halan, B.; Schmid, A.; Buehler K.: “Maximizing the produc-tivity of catalytic biofilms on solid supports in membrane-aerated reactors”, Biotechnology and Bioengineering, 106(4), (2010), 516-527

Holm, A. K.; Blank, L. M.; Oldiges, M.; Schmid, A.; Solem, C.; Jensen, P. R.; Vemuri, G. N.: “Metabolic and transcriptional response to cofactor perturbations in Escherichia coli”, The Journal of Biological Chemistry, 285(23), (2010), 17498-17506

Blank, L. M.; Kuepfer, L.: “Metabolic flux distributions: ge-netic information, computational predictions, and experi-mental validation”, Applied Microbiology and Biotechnology, 86(5), (2010), 1243-1255

Heyland, J.; Fu, J.; Blank, L. M.; Schmid, A.: “Quantitative physiology of Pichia pastoris during glucose-limited high cell-density fed-batch cultivation for recombinant protein production”, Biotechnology and Bioengineering, 107(2), (2010), 357-368

Blank, L. M.; Ebert, B. E.; Buehler, K.; Buehler, B.: “Redox biocatalysis and metabolism: molecular mechanisms and metabolic network analysis”, Antioxidants & Redox Signal-ing, 13(3), (2010), 349-394

Heyland, J.; Antweiler, N.; Lutz, J.; Heck, T.; Geueke, B.; Koh-ler, H.-P. E.; Blank, L. M.; Schmid, A.: “Simple enzymatic pro-cedure for carnosine synthesis: whole-cell biocatalysis and efficient biocatalyst recycling”, Microbial Biotechnology, 3(1) (2010), 74-83

Schmid, A.; Blank, L. M.: “Systems biology: Hypothesis-driven omics integration”, Nature Chemical Biology (News & Views), 6, (2010), 485-487

Kuhn, D.; Blank, L. M.; Schmid, A.; Buehler, B.: “Systems biotechnology - rational biocatalyst and bioprocess design”, Engineering in Life Sciences, 10(5), (2010), 384–397

Rosche, B.; Li, X. Z.; Schmid, A.; Buehler, K.: “Microbial bio-films: A concept for industrial catalysis?”, TRENDS in Bio-technology, 27(11), (2009), 636-643

70

Ruinatscha, R.; Dusny, C.; Buehler, K.; Schmid, A.: “Produc-tive asymmetric styrene epoxidation based on a next gen-eration electroenzymatic methodology”, Advanced Synthe-sis and Catalysis, 351, (2009), 2505-2515

Kortmann, H.; Kurth, F.; Blank, L. M.; Dittrich, P.; Schmid, A.: “Towards real time analysis of protein secretion from single cells”, Lab-on-a-Chip, 9, (2009), 3047-3049

Wierckx, N. J. P.; Ruijssenaars, H. J.; de Winde, J. H.; Schmid, A.; Blank, L. M.: “Metabolic flux analysis of a phenol producing mutant of Pseudomonas putida S12: verifica-tion and complementation of hypotheses derived from transcriptomics”, Journal of Biotechnology, 143(2), (2009), 124–129

Heyland, J.; Fu, J.; Blank, L. M.: “Correlation between TCA cycle flux and glucose uptake rate during respiro-fermen-tative growth of Saccharomyces cerevisiae”, Microbiology, 155, (2009), 3827-3837

Rühl, J.; Schmid, A.; Blank, L. M.: “Selected Pseudomonas putida strains able to grow in high concentrations of bu-tanol”, Applied and Environmental Microbiology, 75(13), (2009), 4653-4656

General

Schmid, A.; Neubauer, P.: “Analytical biotechnology: From single molecule and single cell analyses to population dynamics of metabolites and cells”, Current Opinion in Bio-technology, 21(1), (2010), 1-3

Laboratory ofChemical Process Development (TCA)

Behr, A.; Pérez Gomes, J.; Bayrak, Z.: ”Cross-metathesis of methyl 10-undecenoate with diethyl maleate: Formation of an , -diester via a metathesis reaction network“, Eur. J. Lipid Sci. Technol. 113 (2011), 189-196

FACTS & FIGURES - PUBLICATIONS

Behr, A.; Pérez Gomes, J.: “The cross-metathesis of methyl oleate with cis-2-butene-1,4-diyl diacetate and the influ-ence of protecting groups“, Beilstein J. Org. Chem. 7 (2011), 1-8

Behr,A.; Henze, G.: ”Use of carbon dioxide in chemical syn-theses via a lactone intermediate“, Green Chemistry 13 (2011) 1, 25-39

Behr, A.: ”Catalysis, Homogeneous“, Ullmann’s Encyclopedia of Industrial Chemistry, DOI 10.1002/14356007.o05_o01

Behr, A.; Johnen, L.; Vorholt, A. J.: “Telomerization of Myrcene and Catalyst Separation by Thermomorphic Sol-vent Systems“, ChemCatChem 2 (2010), 1271-1277

Behr, A.; Johnen, L.; Rentmeister, N.: “Novel Palladium-Cat-alysed Hydroamination of Myrcene and Catalyst Separation by Thermomorphic Solvent Systems“, Adv. Synth. Catal. 352 (2010), 2062-2072

Behr, A.; Becker, M.; Reyer, S.: “A highly efficient method for the hydroaminomethylation of long-chain alkenes under aqueous, biphasic conditions“, Tetrahedron Letters 51 (2010), 2438-2441

Behr, A.; Kleyensteiber, A.; Hartge, U.: “Alternative Synthe-sewege zum Ethylen“, Chem.Ing.-Tech. 82 (2010) 3, 201-213

Behr, A.; Pérez Gomes, J.: “The refinement of renewable resources: New important derivatives of fatty acid and glyc-erol”, Eur.J.Lipid Sci. Technol. 112 (2010), 31-50

Behr, A.; Agar, D. W.; Jörissen, J.: “Einführung in die Tech-nische Chemie“, Spektrum - Akademischer Verlag, 2010

Behr, A.; Johnen, L.: “Myrcene as a Natural Base Chemical in Sustainable Chemistry: A Critical Review”, ChemSusChem 2 (2009) 12, 1072-1095

Behr, A.; Neuberg, S.: “Mögliche Nutzungen von Kohlendi-oxid in der chemischen Industrie”, Erdöl Erdgas Kohle 125 (2009) 10, 367-374

71

FACTS & FIGURES - PUBLICATIONS

Behr, A.; Beckmann, T.; Nachtrodt, H.: “Multiphase telomeri-sation of butadiene with phenol: optimisation and scale-up in different reactor types“, Dalton Trans. (2009), 6214-6219

Behr, A.; Vorholt, A.; Johnen, L.: “Aus der Natur für die Chemie“, Nachrichten aus der Chemie 57 (2009), 757-761

Laboratory of Environmental Technology (UT)

Fahlenkamp, H. et al: “Post-Combustion capture with chemical Absorption”, in: Efficient Carbon Capture for Coal Power Plants; Wiley-VCH Verlag GmbH & Co. KGaA, Wein-heim (2011)

Vogt, M.; Goldschmidt, R.; Bathen, D.; Epp, B.; Fahlenkamp, H.: “Comparison of membrane contactor and structured packings for CO2 absorption”; Energy Procedia, 4 (2011), 1471-1477

Epp, B.; Fahlenkamp, H.; Vogt, M.: “Degradation of solutions of Monoethanolamine, Diglycolamine and Potassium Glyci-nate in view of tail-end CO2 absorption”, Energy Procedia, 4 (2011), 75-80

Stankewitz, C.; Fahlenkamp, H.: “Integration of a subse-quent CO2 Scrubbing in the coal-fired power plant pro-cess”; Energy Procedia, 4 (2011), 1395-1402

Nöthe, T.; von Sonntag, C.; Fahlenkamp, H.:“Ozonation of wastewater: rate of ozone consumption and the hydroxyl radical yield”; Environmental Science & Tech-nology, 43 (2009), 5590-5595

Nöthe, T.; Launer, M. J.; von Sonntag, C.; Fahlenkamp, H.:“Computer-assisted determination of reaction parameters for the simulation of micropollutant abatement in waste-water ozonation”; Ozone: Science & Engineering, 32 (2010), 424-429

Laboratory of Equipment Design (AD)

Book contributions

Dreher, S.; Engler, M.; Kockmann, N.; Woias, P.: “Theoretical and Experimental Investigations of Convective Micromixers and Microreactors for Chemical Reactions”, in Micro and Macro Mixing, Bockhorn, H.; Mewes, D.; Peukert, W.; War-necke, H. J. (Eds.) pp. 325–346, Springer Verlag Berlin, 2010

Kockmann, N.: “Microfluidic Networks”, in Micro Process Engineering, Vol. 1, Hessel V.; Renken, A.; Schouten, J.; Yosh-ida, J-i. (Eds.) pp. 41-60, Wiley-VCH Weinheim, 2009

Journal contributions

Kockmann, N.; Gottsponer, M.; Roberge, D. M.: “Scale-up Concept of Single-Channel Microreactors from Process De-velopment to Industrial Production”, Chemical Engineering Journal, 167 (2011), 718-726

Kockmann, N.; Roberge, D. M.: “Transitional Flow and Re-lated Transport Phenomena in Curved Microchannels”, Heat Transfer Engineering, 32 (2011), 595-608

Dittmeyer, R.; Kockmann, N.: “Alles Mikro? Gasphasenkata-lyse“, CIT+, 04 (2011), 46-49

Dittmeyer, R.; Kockmann, N.: “Alles Mikro? Schnelle Reak-tionen in der Flüssigphase“, CIT+, 03 (2011), 19-21

Kockmann, N.; Roberge, D. M.: “Harsh Reaction Conditions in Continuous-Flow Microreactors for Pharmaceutical Production”, Chemical Engineering & Technology, 32 (2009), 1682-1694

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Laboratory of Fluid Mechanics (SM)

Book contributions

Ehrhard, P.: “Microflows”, in: Prandtl – Essentials of Fluid Mechanics, Applied Mathematics Sciences Vol. 158, (ed. Oertel, H. H.), 3rd Edition, Springer, New York, 2010, 639-683

Journal contributions

Wibel, W.; Ehrhard, P.: “Experiments on the laminar/turbu-lent transition of liquid flows in rectangular microchannels”, Heat Transfer Engineering, Vol. 30, (2009), 70-77

Wälter, B.; Ehrhard, P.: “Numerical simulation of electrical double layers and internal electrodes in microchannels”, Proc. Angewandte Mathematik und Mechanik, Vol. 9, (2009), 31-34

Boettcher, K.; Ehrhard, P.: “Stability of a thin layer, spreading on a quasi-rotating disk”, Proc. Angewandte Mathematik und Mechanik, Vol. 9, (2009), 469-470

Lakshmanan, P.; Ehrhard, P.: “Numerical simulation of sin-gle gas bubbles under shear flow conditions”, Proc. Ange-wandte Mathematik und Mechanik, Vol. 9, (2009), 471-472

Lakshmanan, P.; Ehrhard, P.: “Marangoni effects caused by contaminants adsorbed on bubble surfaces”, Journal of Fluid Mechanics, Vol. 647, (2010), 143-161

Stieglitz, I.; Ehrhard, P.: “A hybrid model for electroosmotic flows in microchannels induced by internal electrodes”, Proc. Angewandte Mathematik und Mechanik, Vol. 10, (2010), 461-462

Lakshmanan, P.; Peter, F.; Fries, N.; Ehrhard, P.: “Gas bubbles in simulation and experiment”, Journal of Colloid and Inter-face Science, Vol. 354, (2011), 364-372

Barz, D.; Farangis Zadeh, H.; Ehrhard, P.: “Measurements and simulations of time-dependent flow fields within an electrokinetic micromixer”, Journal of Fluid Mechanics, Vol. 676, (2011), 265-293

FACTS & FIGURES - PUBLICATIONS

Laboratory of Fluid Separations (FVT)

Roth, T.; Lauterbach, S.; Hoffmann, A.; Kreis, P.: “Scale-up und detaillierte Prozessanalyse eines Membranreaktors am Beispiel einer heterogen katalysierten Veresterung”, Chemie Ingenieur Technik 83, (2011), 456-464

Weber, A.; Hoffmann, A.; Górak, A.: “Optimierung der Her-stellung von Biotensiden auf Basis nachwachsender Roh-stoffe”, Chemie Ingenieur Technik 82, (2010), 1239-1243

Kobus, A.; Górak, A.: “Re-Design verfahrenstechnischer Pro-zesse zur Steigerung der Material- und Energieeffizienz in der chemischen Produktion”, Chemie Ingenieur Technik 82, (2010), 563

Altman, E.; Kreis, P.; van Gerven, T.; Stefanidis, G. D.; Stank-iewicz, A.; Górak, A.: “Pilot plant synthesis of n-propyl pro-pionate via reactive distillation with decanter separator for reactant recovery. Experimental model validation and simulation studies”, Chemical Engineering and Processing: Process Intensification, Vol. 49 (2010) 9, 965-972

Koch, K.; Kreis, P.; Müller-Meskamp, S.; Wick, A.; Górak, A.: “Prozessanalyse zum Einsatz von Membrantrennverfahren bei der Umesterung von Fettsäureestern”, Chemie Ingenieur Technik 82, (2010), 704-710

Roth, T.; Kreis, P.: “Rate Based Modelling and Simulation Studies of Hybrid Processes consisting of Distillation, Va-pour Permeation and Adsorption for the Dehydration of Ethanol”, Computer Aided Chemical Engineering 26, (2009), 815-819

Mackowiak, J. F.; Górak, A.; Kenig, E. Y.: “Modelling of com-bined direct-contact condensation and reactive absorption in packed columns”, Chemical Engineering Journal 146, (2009), 362-369

73

FACTS & FIGURES - PUBLICATIONS

Mitkowski, P. T.; Buchaly, C.; Kreis, P.; Jonsson, G.; Górak, A.; Gani, R.: “Computer aided design, analysis and experimen-tal investigation of membrane assisted batch reaction-separation systems”, Computers and Chemical Engineering 33, (2009), 551-574

Kortmann, H.; Chasanis, P.; Blank, L. M.; Franzke, J.; Kenig, E. Y.; Schmid, A.: “The Envirostat – a new bioreactor con-cept”, Lab on a Chip 9, (2009), 576-585

Laboratory of Particle Technology (MV)

Schaldach, G.; Pieloth, D.; Kohnen, B.; Großmann, M.; Walzel, P.: “CFD Simulation der Feststoffeinbindung in ei-nen Sprühstrahl”, Chem. Ing. Tech. 83, (2011) 6, 893-899

Majid, M.; Wiggers, H.; Walzel, P.: “Experimentelle Untersu-chung der Partikelkonzentrationsprofile am Ausgang eines Pilot-Elektrofilters”, Gefahrstoffe – Reinhaltung der Luft 71, (2011) 6, 271-276

Olayiwola, B.; Schaldach, G.; Walzel, P.: “Residence Time Distribution of Steady and Pulsed Flow in a Parallel-Plate Channel with Staggered Fins”, Chem. Eng. Technol. 34, (2011) 6, 937-945

Gramlich, S.; Mescher, A.; Piesche, M.; Walzel, P.: “Modeling and Numerical Simulation of the Gas-Induced Breakup of Liquid Threads Stretched by Gravity”, Chem. Eng. Technol. 34, (2011) 6, 921-926

Walzel, P.; Furuta, T.: “Morpholoy and Properties of Spray Dried Particles” In: Modern Drying Technology, Wiley, Chap-ter 6, Volume 3, Editor E. Tsotsas

Musemic, E.; Walzel P.: “Durchsatzverhalten von Hohl-kegeldüsen”, Chem. Ing. Tech. 83, (2011) 3, 237-246

Gramlich, S.; Mescher, A.; Piesche, M.; Walzel, P.: “Model-lierung und experimentelle Untersuchung des gasinduzier-ten Zerfalls gedehnter Flüssigkeitsstrahlen im Erd-schwerefeld”, Chem. Ing. Tech. 83, (2011) 3, 273-279

Smikalla, M.; Mescher, A.; Walzel, P.; Urbanetz, N. A.: “Im-pact of excipients on coating efficiency in dry powder coat-ing”, International Journal of Pharmaceutics 405, (2011) 1-2, 122-131

Bensmann, S.; Lockow, E.; Walzel, P.; Weihs, C.: “Tracer per-centage prediction of dive reflex samplers”, Powder Tech-nology 208, (2011) 1, 63-71

Majid, M.; Rojek, A.; Wiggers, H.; Walzel P.: “Visualisierung der Rücksprühvorgänge in Staubschichten in Elektrofiltern”, Chem. Ing. Tech. 82, (2010) 12, 2201-2207

Matulka, P.; Walzel, P.: “Partikeltrennung in laminaren Rohrströmungen mit nachgeschalteter Strömungsaufwei-tung”, Chem. Ing. Tech. 82, (2010) 10, 1671-1678

Sellerberg, M.; Walzel, P.: “Verhalten gedehnter Flüssig-keitsfäden in viskosen Flüssig-Flüssig-Systemen”, Chem. Ing. Tech. 82, (2010) 10, 1713-1719

Olayiwola, B.; Schaldach, G.; Walzel, P.: “CFD Study of Ef-fects of Module Geometry on Forced Convection in a Chan-nel with Non-Conducting Fins and Flow Pulsation”, Chem. Eng. Technol. 33, (2010) 10, 1706-1711

Maas, S.; Schaldach, G.; Walzel, P.; Urbanetz, N. A.: “Tailoring dry powder inhaler performance by modifying carrier sur-face topography by spray drying”, Atomization & Sprays 20, (2010) 9, 763-774

Olayiwola, B.; Schaldach, G.; Walzel P.: “Effects of Flow Pul-sation on Forced in a Channel containing Regularly Spaced Non-Conducting Fins”, Chem. Eng. Tech. 33, (2010) 9, 1506-1514

Majid, M.; Wiggers, H.; Walzel P.: “Comparison of dust re-sistivity measurement methods: plate-plate and needle-plate”, Gefahrstoffe Reinhaltung der Luft 70, (2010) 6, 247-250

Mescher, A.; Walzel, P.: “Störeinfluss durch Schlieren bei der Tropfengrößenmessung an Zweistoffdüsen durch La-serbeugungsspektrometrie”, Chem. Ing. Tech. 82, (2010) 5, 717-722

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FACTS & FIGURES - PUBLICATIONS

Bensmann, S.; Subayo, A.; Walzel, P.: “Residence time distri-bution of segregating sand particles in a rotary drum”, Par-ticulate Science and Technology 28, (2010) 4, 319-331

Walzel, P.: “Spraying and Atomizing of Liquids”, Ul-lmann’s Encyclopedia of Industrial Chemistry, Elec-tronic Release, 7th ed., Wiley-VCH, Weinheim, (2009), DOI : 10.1002/14356007.b02_06.pub2

Majid, M.; Mughal, M. T.; Wiggers, H.; Walzel, P.: “Experimen-tal determination of back discharge in electrostatic precipi-tators”, VGB PowerTech 89, (2009) 12, 98-103

Olayiwola, B.; Walzel, P.: “Average Crossflow Velocity in Lam-inar Flow Systems with Periodic Finned Surfaces”, Chem. Eng. Technol. 32, (2009) 10, 1605-1616

Olayiwola, B.; Walzel, P.: “Effects of in-phase oscillation of retentate and filtrate in crossflow filtration at low Reynolds number”, Journal of Membrane Science 345, (2009), 36-46.

Laboratory ofPlant and Process Design (APT)

Adelmann, S.; Schembecker, G.: “Influence of physical properties and operating parameters on hydrodynamics in Centrifugal Partition Chromatography”, (doi:10.1016/j.chroma.2011.01.064)

Adelmann, S.; Schwienheer, C.; Schembecker, G.: “Mul-tiphase flow modeling in Centrifugal Partition Chromato-graphy”, (doi:10.1016/j.chroma.2011.01.063)

Merz, J.; Zorn, H.; Burghoff, B.; Schembecker, G.: “Purifica-tion of a fungal cutinase by adsorptive bubble separation: A statistical approach”, Colloids and Surfaces A: Physico-chemical and Engineering Aspects, 382 (2011), 81–87

Schuldt, S.; Winkelnkemper, T.; Schembecker, G.: “Entwick-lung von Downstream-Prozessen”, in Chmiel, Horst (Hrsg.), Bioprozesstechnik (3. Auflage) Springer Verlag, Heidelberg, (2011), 363-368

Winkelnkemper, T.; Schuldt, S.; Schembecker, G.: “System-atic downstream process development for purification of baccatin III with key performance indicators”, Separation and Purification Technology, 77, (2011), 355-366

Burghoff, B.; Schembecker, G.: “Aufarbeitung: Entwicklung alternativer Verfahren zur Vermeidung des Bottlenecks in der biotechnologischen Produktion”, Chemie & more, 4, (2010), 22-24

Große Daldrup, J.-B.; Held, C.; Sadowski, G., Schembecker, G.; “Modeling pH and Solubilities in Aqueous Multisolute Amino Acid Solutions”, Industrial & Engineering Chemistry Research, 50, (2010), 3503-3509

Kussi, J; Schembecker, G.: “50% Idea: From product to pro-duction conditioning in half times”, Chemie Ingenieur Tech-nik, 82, (2010), 2031-2031

Schlinge, D.; Scherpian, P.; Schembecker, G.: “Comparison of process concepts for preparative chromatography”, Chemi-cal Engineering Science, 65, (2010), 5373-5381

Pansegrau, L.; Bramsiepe, C.; Schembecker, G.: “Diffusive Emissionen von flüssig beaufschlagten Flanschverbin-dungen. Ein Vergleich von Labor- und Betriebsmessungen”, Technische Überwachung, 51 (9), (2010), 29-33

Bramsiepe, C.; Pansegrau, L.; Schembecker, G.: “A model to predict fugitive VOC emissions from liquid charged flange joints with graphite gaskets”, Chemical Engineering Journal 159, (2010), 11-16

Winkelnkemper, T.; Schembecker, G.: “Purification Perform-ance Index and Separation Cost Indicator for experimen-tally based systematic Downstream Process Development”, Separation and Purification Technology, 72 (1), (2010), 34-39

Wohlgemuth, K.; Ruether, F.; Schembecker, G.: “Sonocrys-tallization and Crystallization with Gassing of Adipic Acid”, Chem. Eng. Sci. 65, (2010), 1016-1027

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FACTS & FIGURES - PUBLICATIONS

Winkelnkemper, T.; Schembecker, G.: “Purification Finger-prints for experimentally based systematic Downstream Process Development”, Separation and Purification Tech-nology, 71, (2010), 356-366

Große-Daldrup, J.-B.; Held, C.; Ruether, F.; Sadowski, G.; Schembecker, G.: “Measurement and modeling solubility of aqueous multi solute amino acid solutions”, Industrial & Engineering Chemistry Research, 49, (2010), 1395-1401

Wohlgemuth, K.; Kordylla, A.; Ruether, F.; Schembecker, G.: “Experimental Study of the Effect of Bubbles on Nucleation during Batch Cooling Crystallization”, Chemical Engineering Science 64 (19), (2009), 4155-4163

Merz, J.; Schembecker, G.; Riemer, S.; Nimtz, M.; Zorn, H.: “Purification and identification of a novel cutinase from Co-prinopsis cinerea by adsorptive bubble separation”, Separa-tion and Purification Technology, 69, (2009), 57-62

Scherpian, P.; Schembecker, G.: “Scaling up Recycling Chro-matography”, Chemical Engineering Science, 64, (2009), 4068-4080

Laboratory of Process Dynamics and Operations (DYN)

Book contributions

Cui, J.: “A medium-term production planning problem: The EPS logistics.”, in: Linear Programming - New Frontiers in Theory and Applications, Nova Publishers, (2011), Chapter 7

Cui, J.: ”Two-stage stochastic mixed integer linear program-ming.”, in: Linear Programming - New Frontiers in Theory and Applications, Nova Publishers, (2011), Chapter 1

Engell, S.; Handschin, E.; Rehtanz, C.; Schulz, R.: “Capacity planning and scheduling in electrical power systems and in chemical and metallurgical production plants”, in: Gröt-schel, M.; Lucas, K.; Mehrmann, V. (Hrsg.) : Production Fac-tor Mathematics, Springer-Verlag Berlin, (2010), 279-305

Sonntag, C.: “Modeling, Simulation, and Optimization Envi-ronments. “, Handbook of Hybrid Systems Control - Theory, Tools, Applications, Cambridge University Press, (2009), 325-360

Engell, S.; Lohmann, S.; Moor, T.; de Prada, C.; Raisch, J.; Sonntag, C.; Sarabia, D.: “Industrial controls”, in: Lunze, J.; Lamnabhi-Lagarrigue, F. (Hrsg.) : The HYCON Handbook of Hybrid Systems: Control Theory - Tools - Applications, Cam-bridge University Press, Cambridge UK, (2009), 405-437

van Beek, D. A.; Engell, S.: “Overview of tools development and open problems.”, in: Lunze, J.; Lamnabhi-Lagarrigue, F. (Hrsg.): The HYCON Handbook of Hybrid Systems: Control Theory - Tools - Applications, Cambridge University Press, (2009), 279-283

Journal contributions

Urselmann, M.; Engell, S.: “Flowsheet Optimization By Me-metic Algorithms.” Computer Aided Chemical Engineering, 29, (2011), 231-235

Urselmann, M.; Barkmann, S.; Sand, G.; Engell, S.: “Optimi-zation-based Design of Reactive Distillation Columns Using a Memetic Algorithm“, Computers & Chemical Engineering 35 (5), (2011), 787-805

Tometzki, T.; Engell, S.: “Systematic Initialization Techniques for Hybrid Evolutionary Algorithms for Solving Two-Stage Stochastic Mixed-Integer Programs”, Transactions on Evo-lutionary Computation 15, (2011), 196-214

Fischer, S.; Engell, S.: “Werkzeugunterstützung für den Ent-wurf von Ablaufsteuerungen auf Basis informeller Spezi-fikationen“, at- Automatisierungstechnik 59, (2011), 50-61

Hüfner, M.; Tometzki, T.; Kraja, T.; Engell, S.: “Learn2Control: Eine webbasierte Lernumgebung im Bio- und Chemie-ingenieurwesen“, Journal Hochschuldidaktik 22. Jg., (2011), 20-23

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Subbiah, S.; Schoppmeyer, C.; Engell, S.: “An Intuitive and Efficient Approach to Process Scheduling with Sequence-Dependent Changeovers Using Timed Automata Models”, Industrial and Engineering Chemistry Research (Special Is-suse to honour Prof. Luis Puigjaner), (2011), 5131-5152

Subbiah, S.; Engell, S.: “Short-Term Scheduling of Multi-Product Batch Plants with Sequence-Dependent Change-overs Using Timed Automata Models”, Computer Aided Chemical Engineering, (2010), 1201-1206

Tometzki, T.; Engell, S.: ”Risk management in production planning under unvertainty by multi-objective hybrid evolu-tionary algorithms.”, Computer Aided Chemical Engineering 28 C, (2010), 151-156

Subbiah, S.; Engell, S.: ”Short-term scheduling of multi-pro-duction batch plants with sequence-dependent change-overs using time automata models.”, Computer Aided Chemical Engineering 28 C, (2010), 1201-1206

Piana, S.; Engell, S.: “Hybrid Evolutionary Optimization of the Operation of Pipeless Plants”, Journal of Heuristics - Special Issue on Advances in Metaheuristics 16, (2010), 311-336

Küpper, A.; Wirsching, L.; Diehl, M.; Schlöder, J. P.; Bock, H.G.; Engell, S.: “Online Identification of Adsorption Isotherms in SMB Processes via Efficient Moving Horizon State and Parameter Estimation”, Computers & Chemical Engineering 34, (2010), 1969-1983

Frimat, J.-P.; Sisnaiske, J.; Subbiah, S.; Menne, H.; Godoy, P.; Lampen, P.; Leist, M.; Franzke, J. G.; Hengstler, J.: “The Net-work Formation Assay: A Spatially Standardized Neurite Outgrowth Analystical Display for Neurotoxicity Screening”, Lab On Chip 10 (2010), 701-709

Fischer, S.; Engell, S.: “Werkzeugunterstützung für den Ent-wurf von Ablaufsteuerungen auf Basis informeller Spezi-fikationen.“, at- Automatisierungstechnik 59, (2011), 50-61

Cui, J.; Engell, S.: “Medium-term Planning of a Multiproduct Batch Plant under Evolving Multi-period Multi-uncertainty by Means of a Moving Horizon Strategy”, Computers and Chemical Engineering 34, (2010), 598-619

Bouaswaig, A.; Engell, S.: “Comparison of high resolution schemes for solving population balances”, Industrial & En-gineering Chemistry Research 49, (2010), 5911-5924

Subbiah, S.; Engell, S.: ”Timed automata models for batch scheduling with sequence dependent changeovers”, Com-puter Aided Chemical Engineering 27 C, (2009), 1515-1520

Engell, S.: ”Online optimizing control: the link between plant economics and process control”, Computer Aided Chemical engineering 27 C, (2009), 79-86

Vautz, W.; Mauntz, W.; Engell, S.; Baumbach, J.: “Monitoring of Emulsion Polymerisation Processes using Ion Mobility Spectrometry? A Pilot Study”, Macromolecular Reaction En-gineering, (2009), 85-90

Tometzki, T.; Engell, S.: “Hybrid Evolutionary Optimization of Two-Stage Stochastic Integer Programming Problems: An Empirical Investigation”, Evolutionary Computation 17, (2009), 511-526

Subbiah, S.; Tometzki, T.; Panek, S.; Engell, S.: “Multi-pro-duct Batch Scheduling with Intermediate Due Dates Using Priced Timed Automata Models“, Computers and Chemical Engineering 33, (2009), 1661-1676

Lieftucht, D.; Völker, M.; Sonntag, C.; Kruger, U.; Irwin, G. W.; Engell, S.: ”Improved Fault Diagnosis in Multivariate Systems using Regression-based Reconstruction“, Control Engineering Practice 17, (2009), 478-493

Küpper, A.; Engell, S.: “Optimierungsbasierte Regelung des Hashimoto-SMB-Prozesses“, at-Automatisierungstechnik 57 (7), (2009), 360-370

FACTS & FIGURES - PUBLICATIONS

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FACTS & FIGURES - PUBLICATIONS

Hüfner, M.; Tometzki, T.; Engell, S.: “Two-layer planning and scheduling of batch production processes under uncer-tainty”, Computer Aided Chemical Engineering 27 C, (2009), 1197-1202

Küpper, A.; Diehl, M.; Schlöder, J. P.; Bock, H. G.; Engell, S.: “Real-time Moving Horizon State and Parameter Estima-tion for SMB Processes“, Computer Aided Chemical Engi-neering 27 C, (2009), 1233-1238

Pham, L. C.; Engell, S.: “Control structure selection based upon rigorous dynamic process models”, Computer Aided Chemical Engineering 27 C, (2009), 1347-1352

Reviewed Conference contributions

Tran, T. H.; Engell, S.: “Design of State Observers for Dis-cretely Controlled Continuous Systems“, in: Proceedings CONTROL 2010, Coventry/ UK, (2010), 1113-1118

Sonntag, C.; Fischer, S.: “Translating Sequential Function Charts to the Compositional Interchange Format for Hybrid Systems“, in: Proceedings 49th IEEE Conference on Deci-sion and Control (CDC10), (2010), 4250-4256

Shah, G.; Engell, S.: “Tuning MPC for Desired Closed-Loop Performance for SISO Systems“, in: Proceedings 18th Medi-terranean Conference on Control and Automation, Marra-kech/Morocco, (2010), 628-633

Neymann, T.; Wegerhoff, S.; Engell, S.: “Modelling and Simu-lation of Budding Yeast Cultures”, in: Proceedings IFAC, 11th Computer applications in biotechnology, Leuven, (2010), 461-466

Gholamzadeh Nabati, E.; Engell, S.: “An Improved Adaptive Control Algorithm Based Upon Unfalsified Control“, Proc. CD. IFAC ALCOSP Workshop, Antalya/Türkei, (2010), ID 68

Bouaswaig, A. E.; Engell, S.: “An Inverse Problem Approach to Extract the Growth Kernel in Particulate Processes”, in: Proceedings 9th International Symposium on Dynamics and Control of Process Systems (DYCOPS), Leuven/Belgien, (2010), 389-394

Tran, T. H.; Engell, S.: “Design of Logic Feedback Controllers for Discretely Controlled Continuous Systems”, in: Proceed-ings 3rd IFAC Conference on Analysis and Design of Hybrid Systems (ADHS’09), Zaragoza /Spain, (2009), 126-131

Sonntag, C.; Kölling, M.; Engell, S.: “Sensitivity-based Pre-dictive Control of a Large-scale Supermarket Refrigeration System”, in: Proceedings ADCHEM 2009, Istanbul, 354-359

Küpper, A.; Diehl, M.; Schlöder, J. P.; Bock, H. G.; Engell, S.:“Efficient Moving Horizon State and Parameter Estimation for the Varicol SMB Process”, in: Proceedings ADCHEM 2009 Istanbul, (2009), 619-624

Wonghong, T.; Engell, S.: “Application of a New Scheme for Adaptive Unfalsified Control to a CSTR with Noisy Meas-urements”, in: Proceedings ADCHEM 2009 Istanbul, (2009), 962-967

Pham, L. C.; Engell, S.: “Control Structure Selection for Optimal Disturbance Rejection “, in: Proceedings IEEE Multi-conference on Systems and Control (MSC), Sankt Petersburg, (2009), 707-712

Laboratory of Reaction Engineering (TCB)

Bludowsky, T.; Agar, D. W.: “Thermally integrated bio-syngas-production for biorefineries”, Chemical Engineering Re-search and Design (2009), 87(9), 1328-1339

Mendorf, M.; Nachtrodt, H.; Agar, D. W.: “Externes Num-bering-up für flüssig-flüssig Systeme in Kapillarreaktoren”, Chemie Ingenieur Technik (2009) 82, 259-264

Ghaini, A.; Mescher, A.; Franzke, J.; Agar, D. W.: “Be-rührungslose Überwachung mehrphasiger Mikrokapil-larströmungen anhand ihrer dielektrischen Eigenschaften”, Chemie Ingenieur Technik (2010), 82(4), 545–552

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FACTS & FIGURES - PUBLICATIONS

Bludowsky, T.; Pfaff, J.; Agar, D. W.: “Selektivitätsunter-suchungen beim Hochdruck-Aqueous-Phase-Reforming”,Chemie Ingenieur Technik (2010), 82(9), 1330-1331

Ghaini, A.; Kashid, M. N.; Agar, D. W.: “Effective interfacial area for mass transfer in the liquid–liquid slug flow capil-lary microreactors”, Chemical Engineering and Processing (2010), 49, 358–366

Mendorf, M.; Nachtrodt, H.; Mescher, A.; Ghaini, A.; Agar, D. W.: “Design and Control Techniques for the Numbering-up of Capillary Microreactors with Uniform Multiphase Flow Distribution”, Industrial & Engineering Chemistry Research (2010), 49(21), 10908-10916

Zhang, J.; Chen, J.; Misch, R.; Agar, D. W.: “Carbon dioxide absorption in biphasic amine solvents with enhanced low temperature solvent regeneration”, Chemical Engineer-ing Transactions (2010), Vol 21, 169-147; DOI: 10.3303/CET1021029

Jung, S.; Becker, M.; Agar, D. W.; Franke, R.: “Eindimensio-nale Modellierung und Simulation von Blasensäulenreak-toren”, Chemie Ingenieur Technik (2010), 82, No. 10, 1743-1751

Jung, S.; Becker, M.; Agar, D. W.; Franke, R.: “One-Dimen-sional Modeling and Simulation of Bubble Column Reac-tors”, Chemical Engineering Technology (2010), 33, No. 12, 2037–2043

Franke, R.; Hannebauer, B.; Jung, S.: “A Case Study in the Pre-Calculation of Henry Coefficients”, Chemical Engineer-ing Technology (2010), 33, No. 2, 251-257

Franke, R.; Hannebauer, B.; Jung, S.: “Fallstudie zur Voraus-berechnung Henryscher Koeffizienten”, Chemie Ingenieur Technik (2010), 82, No. 3, 265-272

Ufer, A.; Sudhoff, D.; Mescher, A.; Agar, D. W.: “Suspension catalysis in a liquid-liquid capillary microreactor”, Chemical Engineering Journal (2011), 167(2-3), 468-474

Mendorf, M.; Moenter, A.; Moll, T.; Agar, D. W.; Tiller, J. C.: “Polymerization of Butyl Acrylate in the Two Phase Slug Flow Regime of Parallel Microcapillary Reactors”, Macromo-lecular Symposia (2011), 302, 245-256

Ghaini, A.; Mescher, A.; Agar, D. W.: “Hydrodynamic studies of liquid-liquid slug flows in circular microchannels”, Chem-ical Engineering Science (2011) 66(6), 1168-1178

Zhang, J.; Nwani, O.; Tan, Y.; Agar, D. W.: “Carbon dioxide ab-sorption into biphasic amine solvent and reduction of sol-vent losses”, Chem. Eng. Res. & Des. (2011), DOI:10.1016/j.cherd.2011.02.005

Zhang, J.; Agar, D. W.; Zhang, X.; Geuzebroek, F.: “CO2 ab-sorption in biphasic solvents with enhanced low tempera-ture solvent regeneration”, Energy Procedia (2011), 4, 67-74

Scheiff, F.; Mendorf, M.; Agar, D. W.; Reis, N.; Mackley, M.: “The separation of immiscible liquid slugs within plastic micro-channels using a metallic hydrophilic sidestream”, Lab on a Chip, (2011), 11 (6), 1022 – 1029

Kreysa, G.; Agar, D. W.; Schultz, I.: “Decarbonisation of Fossil Energy via Methane Pyrolysis”, Proceedings of DGMK Con-ference, Berlin, 4.-6. Okt. 2010

Laboratory ofTechnical Biochemistry (TB)

Hendrawati, O.; Woerdenbag, H. J.; Hille, J.; Kayser, O.: “Sea-sonal variations in the deoxypodophyllotoxin content and yield of Anthriscus sylvestris L. (Hoffm.) grown in the field and under controlled conditions”, Journal Agricultural Food Chemistry (2011), 8132-8139

Limsuwan, S.; Hesseling-Meinders, A.; Voravuthikunchai, S.P.; van Dijl, J. M.; Kayser, O.: “Potential antibiotic and anti-infective effects of rhodomyrtone from Rhodomyrtus tomentosa (Aiton) Hassk. on Streptococcus pyogenes as revealed by proteomics”, Phytomedicine (2011), 934-940

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Rydén, A. M.; Ruyter-Spira, C.; Quax, W. J.; Osada, H.; Mu-ranaka, T.; Kayser, O.; Bouwmeester, H.: “The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua”, Planta Medica (2010), 1778-1783

Rydén, A. M.; Ruyter-Spira, C.; Litjens, R.; Takahashi, S.; Quax, W.; Osada, H.; Bouwmeester, H.; Kayser, O.: “Molecu-lar cloning and characterization of a broad substrate ter-penoid oxidoreductase from Artemisia annua”, Plant Cell Physiology (2010), 1219-1228

Rana, A.; Seinen, E.; Siudeja, K.; Muntendam, R.; Srinivasan, B.; van der Want, J. J.; Hayflick, S.; Reijngoud, D. J.; Kayser, O.; Sibon, O. C.: ”Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration”, Pro-ceedings of the National Academy of Science USA (2010), 6988-6993

Lemke, A.; Kiderlen, A. F.; Petri, B.; Kayser, O.: “Delivery of amphotericin B nanosuspensions to the brain and determi-nation of activity against Balamuthia mandrillaris amebas”, Nanomedicine (2010) 6, 597-603

Hendrawati, O.; Woerdenbag, H.J.; Hille, J.; Kayser, O.: “Metabolic engineering strategies for the optimization of medicinal and aromatic plants: realities and expectations“, Zeitschrift für Gewürz- und Arzneipflanzen, (2010) 15, 111-126

Laboratory ofThermodynamics (TH)

Ruether, F.; Sadowski, G.: “Solubility of complex natural and pharmaceutical substances”, in: Industrial Scale Natural Products Extraction, Eds. H.-J. Bart and S. Pilz, Weinheim, Wiley-VCH 2011

Sadowski, G.: “Modeling of Polymer Phase Equilibria Using Equations of State”, in: Advances in Polymer Science 238, 2011, 389-418, Springer-Verlag Berlin Heidelberg 2010

Held C.; Sadowski, G.: “Modelling Specific Ion Effects in En-gineering Science”, in: Specific Ion Effects. World Scientific Publishing Co. Pte. Ltd.Singapore 2010

Kleiner M.; Tumakaka, F.; Sadowski, G.: “Thermodynamic Modeling of Complex Systems”, in: Structure and Bonding, Springer-Verlag 2009

Mollerup, J. M.; Breil, M. P.; Vogelpohl, C.; Sadowski, G.: “Si-multaneous Correlation of Hydrophobic Interactions in HIC and Protein Solubility in Aqueous Salt Solutions and Mixed Solvents”, Fluid Phase Equilibria, 301, (2011), 163-170

Große-Daldrup, J.-B.; Held, C.; Sadowski, G.; Schembecker, G.: “Modeling pH and Solubilities in Aqueous Multisolute Amino Acid Solutions”, Ind. Eng. Chem. Res., 50 (2011) 3503-3509

Poggendorf, S.; Adama Mba, G.; Engel, D.; Sadowski, G.: “Dif-fusion of PEG in NIPAAm Hydrogels with Confocal Raman Spectroscopy”, Colloid and Polymer Science, 289, (2011), 545-559

Held, C.; Cameretti, L. F.; Sadowski, G.: “Measuring and Modeling Activity Coefficients in Aqueous Amino-Acid Solu-tions”, Ind. Eng. Chem. Res., 50, (2011), 131-141

Rüther, F.; Sadowski, G.: “Thermodynamische Berechnungs-methoden für Löslichkeiten“, Chemie Ingenieur Technik, 83, (2011),496-502

Wohlgemuth, K.; Ruether, F.; Schembecker, G.: “Sonocrys-tallization and Crystallization with Gassing of Adipic Acid”, Chemical Engineering Science, 65, (2010), 1016-1027

Brandenbusch, C.; Sadowski, G.: “Supercritical phase be-havior for biotransformation processing”, J. Supercritical Fluids, 55, (2010), 635-642

Cassens, J.; Ruether, F.; Leonhard, K.; Sadowski, G.: “Solu-bility Calculation of Pharmaceutical Compounds using Quantum-Chemical Methods”, Fluid Phase Equilibria, 299, (2010), 161-170

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FACTS & FIGURES - PUBLICATIONS

Miao, B.; Vilgis, T. A.; Poggendorf, S.; Sadowski, G.: “Effect of Finite Extensibility on the Equilibrium Chain Size”, Macro-mol. Theory Simul., 19, (2010), 414-420

Müller, F.; Heuwers, B.; Katzenberg, F.; Tiller, J. C.; Sadowski, G.: “Creep-tension measurements of glassy solvent-loaded polymers”, Macromolecules, 43, (2010), 8997-9003

Naeem, S.; Sadowski, G.: “pePC-SAFT: Modeling of Polyelec-trolyte Systems. 1. Vapour-Liquid Equilibria”, Fluid Phase Equilibria, 299, (2010), 84-93

Kiesow, K.; Ruether, F.; Sadowski, G.: “Solubility, Crystalliza-tion and Oiling-out Behavior of PEGDME. 1. Pure-Solvent Systems”, Fluid Phase Equilibria, 298, (2010), 253-261

Held, C.; Neuhaus, T.; Sadowski, G.: “Compatible solutes: thermodynamic properties and biological impact of ec-toines and prolines”, Biophys. Chem., 152, (2010), 28-39

Brandenbusch, C.; Bühler, B.; Hoffmann, P.; Sadowski, G.; Schmid, A.: “Efficient Phase Separation and Product Recov-ery in Organic-Aqueous Bioprocessing Using Supercritical Carbon Dioxide”, Biotechnology and Bioengineering, 107, (2010), 642-651

Große-Daldrup, J.-B.; Held, C.; Ruether, F.; Schembecker, G.; Sadowski, G.: “Measurement and modeling solubility of aqueous multi solute amino acid solutions”, Ind. Eng. Chem. Res., 49, (2010), 1395-1401

Wohlgemuth, K.; Kordylla, A.; Ruether, F.; Schembecker, G.: “Experimental Study of the Effect of Bubbles on Nucleation during Batch Cooling Crystallization”, Chem. Eng. Sci. 2009, 64, (19), 4155-4163

Ruether, F.; Sadowski, G.: “Modeling the solubility of phar-maceuticals in pure solvents and solvent mixtures for drug process design.”, J. Pharmaceutical Sci., 98, (2009), 4205-4255 81

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PublisherDepartment Chair Prof. Sebastian EngellFakultät Bio- und ChemieingenieurwesenTechnische Universität Dortmund

AddressEmil-Figge-Str. 70D-44227 DortmundGermany

+49-(0)231-755-2362 +49-(0)231-755-2251

EditorDr. Paul Kerzel

Layout Cornelia Nowicki

GraphicCornelia Nowicki Kirsten Lindner-Schwentick

PhotographyFakultät Bio- und ChemieingenieurwesenTU Dortmund

PrinterHeinze Druck & KommunikationRuhrallee 62D-44139 Dortmund

Printing run500September 2011

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