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BIENNIAL INTERNATIONAL CONGRESS ON THROMBOSIS MAY 23-26, 2018 Palazzo del Casino Venice Convention Center VENICE-ITALY www.thrombosis2018.org

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www.thrombosis2016.org

Istanbul, Turkey-May 4-7, 2016HALIÇ CONGRESS CENTER

BIENNIAL

INTERNATIONAL

CONGRESS ON THROMBOSIS

MAY 23-26, 2018Palazzo del Casino

Venice Convention Center

VENICE-ITALY

GESTIÓN DE CONGRESOS Y SOCIEDADES

TECHNICAL SECRETARIATT 34 93 221 22 42 ww.geyseco.es - [email protected]

www.thrombosis2018.org

2

WEDNESDAY, MAY 23 2018PERLA ROOM 

OPENING LECTURES

Introduction and chair: V. Pengo (Italy) and P. Prandoni (Italy)

14:00-15:30 THROMBOSIS BURDEN AND LIFE EXPECTANCY

14:00-14:30 The secret for a longer life expectancy

G. De Gaetano (Italy)

14:30-15:00 Influence of air pollution on life expectancy

P. M. Mannucci (Italy)

15:00-15:30 Hereditary Thrombophilia after 60 years: an update

P. Simioni (Italy)

Solicited reviews

Introduction: S. Iliceto (Italy)

15:30-16:00 Pulmonary Baloon Angioplasty: present and future

Z.C Jing (China)

16:00-17:00 BASIC SCIENCE (I)

  Chairs M.Camera (Italy) and V.Pengo (Italy)

  1. Complement-mediated endothelial damage 

L. Roumenina (France)

2. New anti-platelet therapies 

  D. Varon (Israel)

17:00-18:00 OPENING CEREMONY

V.Pengo(Italy) and A.M. Demir(Turkey)

3

THURSDAY, MAY 24 2018PERLA ROOM

09:00-11:00 STROKE PREVENTION IN ATRIAL FIBRILLATION

Chairs: R. De Caterina (Italy) and S. Iliceto (Italy)

1. NOACs use 2018: Does it still matter if for valvular or non-valvular Atrial Fibrillation? 

R. De Caterina (Italy)

2. How much atrial fibrlillation do you need to create a thrombus? 

A. Cappucci (Italy)

3. Risk stratification in AF: is everything clear?      

L. Friberg (Sweden)   

4.  Why do renal disease progress and how not to reach end-stage

G. Remuzzi (Italy)

5. Left Atrial Appendage occlusion: in whom? 

G. Patti (Italy)

11.40-12.00 COFFEE BREAK

12.00-13.00 ORAL PRESENTATIONS VENOUS THROMBOEMBOLISM I (7MINUTES + 3 DISCUSSION)

Chairs: D. Poli (Italy) and P. Colonna (Italy)

 

C0219 Accp Score to Assess the Risk of Bleeding During Anticoagulation: Application to Real-Life Data from the Start2-Registry Gualtiero Palareti, Emilia Antonucci, Daniela Mastroiacovo, Walter Ageno, Vittorio Pengo, Daniela Poli, Sophie Testa, Alberto Tosetto, Paolo Prandoni

 C0293 The Impact of Increased Systolic Pulmonary Artery Pressure on the Late Outcome of Patients with

Pulmonary Embolism. The Scope Investigators Group Raffaele Pesavento, Lucia Filippi, Paolo Prandoni

 

C0320 Safety And Efficiency Of Fixed Vs Age-Adjusted D-Dimer As Stand-Alone Tests In The Diagnostic Work-Up Of Deep Vein ThrombosisSynne G Fronas, Anders Dahm, Hilde Skuterud Wik, Frederikus Klok, Camilla Tøvik Jørgensen, Jostein Gleditsch, Nezar Raouf, Waleed Ghanima.

 

C0091 Case-Fatality Rate Of Recurrent Vte After Anticoagulant Treatment Cessation In Unprovoked Vte: A Systematic Review And Meta-AnalysisSake Van Der Wall, Liselotte Van Der Pol, Yvonne Ende-Verhaar, Suzanne Cannegieter, Sam Schulman, Paolo Prandoni, Marc Rodger, Menno Huisman, Frederikus Klok

 

C0173 Predicting Recurrence after Unprovoked Venous Thromboembolism: Retrospective Validation of the Damoves ScoreAna Isabel Franco Moreno, María José García Navarro, Cristina Lucía De Ancos Aracil, Alejandra Gimeno García, Carmen Montero Hernández, Ana Villa Martínez, Víctor Piedrafita Mateo, Judith Ortiz Sánchez, Irene Carmen Sanz Acevedo, José Manuel Ruiz Giardín

 

C0135 Venous Thromboembolism after Joint Surgery or TraumaJavier Gutiérrez-Guisado, Javier Trujillo-Santos, Juan Ignacio Arcelus, Laurent Bertoletti, Carmen Fernández-Capitán, Reina Valle, José Antonio Hernández-Hermoso, Alejo Erice Calvo-Sotelo, Jose Antonio Nieto, Manuel Monreal, Riete Investigators

13.00-14.00 LUNCH SYMPOSIUM - THROMBOSIS RESEARCH INSTITUTE 

Prevention of Venous Thromboembolism Rt Hon

A. Kakkar (UK) 

Treatment of Venous Thromboembolism 

P. Prandoni (Italy)

4

14.00-14.30 ORAL PRESENTATIONS ATHEROSCLEROSIS (7MINUTES +3 DISCUSSION) 

V. Pengo (Italy)

 

C0063 An International Collaboration Between Sweden and France to Assess the Risk Factors of Thrombosis in Immune Thrombocytopenia AdultsCharlotta Ekstrand, Bérangère Baricault, Marie Linder, Margaux Lafaurie, Laurent Sailler, Maryse Lapeyre-Mestre, Helle Kieler, Shahram Bahmanyar, Guillaume Moulis

 

C0309 Otogenic Lateral Sinus Thrombosis in Children: Are There Prognostic and Predictor Factors? Experience of 25 Cases and a Proposal of a Management ProtocolSilvia Foligno, Alessandro Scorpecci, Michela Massoud, Sara Giannantonio, Paola Zangari, Giovina Di Felice, Antonio Minozzi, Pasquale Marsella, Matteo Luciani

  C0281 Diagnostic Difficulties of Coronary EmbolismLászló Balogh, Péter Óvári

14.30-16.30 RECENT ADVANCES IN THROMBOTIC MICROANGIOPATHIES 

Chairs: P. Minuz (Italy) and V. Pengo (Italy)

  1. Innate immunity, inflammation and thrombosis 

T. Padró (Spain)

2. Thrombotic Thrombocytopenic purpura 

B. Ferrari (Italy)

4. Cathastrophic Antiphospholipid Syndrome 

A. Ruffatti (Italy)

5. Disseminated Introvascular Coagulation 

M. Levi (The Netherlands)

16.30-17.30 DEBATES

Chairs: G. Patti (Italy)

Treatment in patients with non gender related CHADVASC 1

YES P. Colonna (Italy)

NO F. Verheugt (The Netherlands)

17:30-18:30 POSTER VIEWING IN POSTER AREA

VOLPI ROOM

09.00-11.00 CANCER AND THROMBOSIS

Chairs: A. Falanga (Italy) and A. Kakkar (United Kingdom)

1. Search for occult cancer in patients with unprovoked VTE

M. Righini (Switzerland)

2. Controversies in the management of cancer associated thrombosis 

A. Kakkar (UK)

3. The role of biomarkers for assessing the risk of CAT

J. Thaler (Austria)

4. The role of NOACs 

W. Ageno (Italy)

11.00-11.30 COFFEE BREAK

5

11.30-13.00 ARTERIAL AND VENOUS THROMBOSIS

  Chairs: B. Cosmi (Italy) and Prandoni (Italy)

1. Venous and arterial thrombosis: reappraisal 

P. Prandoni (Italy)

2. The optimal duration of anticoagulation in the era of NOACs 

G. Palareti (Italy)

3. Risk of AMI and stroke in women on hormonal therapy

O. Lidegaard (Denmark)

4. Hormonal treatment in women with thrombosis 

I. Martinelli (Italy)

13.00-14.00 LUNCH SESSION 

14.00-14.30 ORAL PRESENTATIONS MISCELLANEA (7 MINUTES + 3 DISCUSSION)

Chair: Teresa Sartori (Italy)

  C0074 Intracranial Bleeding Risk After a Mild Traumatic Brain Injury in Patients on Antithrombotic DrugsSilvia Galliazzo, Lorenza Bertù, Massimo Dario Bianchi, Andrea Trucchi, Alexandra Virano, Walter Ageno

 

C0048 Evaluation of the Plasmic Score for the Prediction of ADAMTS13 Activity in Patients with Thrombotic MicroangiopathiesGiovanni Tiscia, Filomena Cappucci, Potito Scalzulli, Nicola Cascavilla, Cosima Battista, Antonio Abrescia, Filippo Aucella, Caterina Buquicchio, Maurizio Bregante, Giovanna Dandrea, Bruno Di Paolo, Giulio Giordano, Barbara Infante, Silvia Piano, Prudenza Ranieri, Livio Tullo, Angelo Ostuni, Elvira Grandone

  C0050 Apolipoproteins C-I, -II, -III and E, Coagulation Activity and Risk of Venous ThromboembolismFernanda Andrade Orsi, Willem Lijfering, Frits Rosendaal, Suzanne Cannegieter

14.30-16.00 NON VITAMIN K ORAL ANTICOAGULANTS (NOACS)

  Chairs: F. Marongiu (Italy) and R. De Cristofaro (Italy)

1. NOACs adherence and persistence 

F. Marongiu (Italy)

2. Reversal of NOACs (antidotes) 

M.T. Sartori (Italy)

3. NOACs in frail patients 

M. Monreal (Spain)

16.00-17.00 DEBATES

Chair: S. Testa (Italy) and M.B. Donati (Italy)

Determination of NOACs concentration

Yes A. Tripodi (Italy)

No M. Huisman (The Netherlands)

17:00-18:00 POSTER VIEWING IN POSTER AREA

17:30-18:30 SYMPOSIUM ON SULODEXIDE ON PREVENTION AND TREATMENT OF DVT

Chairs: P. Prandoni (Italy) and G. Palareti (Italy)

17:30-18:00 Treatment of DVT and its complications 

G. Palareti (Italy)

18:00-18:15 Future perspectives

P. Prandoni (Italy)

18:15-18:30 Discussion

6

FRIDAY, MAY 25 2018PERLA ROOM

09.00-11.00 ARTERIAL THROMBOSIS

  Chairs: R. Marcucci (Italy) and A. Rubboli (Italy)

  1. Stable CAD in AF patients on NOACs

M. Lettino (Italy)

  2. AF, PCI and triple therapy: which antiplatelet drug should be discontinued 

R. Storey (United Kingdom)

  3. Women thrombosis and cancer: a gender specific analysis 

B. Brenner (Israel)

4. Optimal duration of dual antiplatelet therapy: still a dilemma?

A. Rubboli (Italy)

  5. Ischemic stroke while on NOACs

D. Toni  (Italy)

11.00-11.30 COFFEE BREAK

11.30-13.00 LABORATORY THROMBOSIS

  Chairs: T. Ulutin (Turkey) and M. B. Mijovski (Slovenia)

  1. Improved FXa Generation Assays and Hypercoagulability in Coronary Artery Disease

F. Bernardi (Italy)

  2. Catheter-associated thrombosis: forgetting well-known 

E. Roytman (Russia)

  3. On the way to the harmony between clinical needs and lab capabilities

T. Vavilova (Russia)

  4. Global assays in anticoagulation management 

M. B. Mijovski (Slovenia)

13.00-14.00 LUNCH SYMPOSIUM

14.00-15.00 ORAL PRESENTATIONS VENOUS THROMBOEMBOLISM II (7 MINUTES + 3 DISCUSSION) 

Chair: D. Prisco (Italy) and V. De Filippis (Italy)

  C0017 Initial Results of Oral Thrombolytic Agent Clinical ApplicationPavel Madonov, Svetlana Mishenina, Dmitriy Kinsht, Stanislav Leontiev, Sergey Zotov, Maksim Ufimtsev

 C0294 The Diagnosis of Isolated Subsegmental Pulmonary Embolism is Poorly Reproducible in Symptomatic

PatientsRaffaele Pesavento, Davide Ceccato, Giorgio De Conti, Raffaella Motta, Paolo Prandoni

 C0327 Impact Analysis of Prognostic Stratification for Pulmonary Embolism: The Iapp Study

Marco Donadini, Walter Ageno, Marco Cei, Francesco Dentali, Patrizia Fenu, Nicola Mumoli, Fulvio Pomero, Roberta Re, Gerardo Palmiero, Laura Spadafora; Alessandro Squizzato

 

C0188 Rosuvastatin Use Reduces Thrombin Generation in Patients with Venous Thromboembolism: Results from a Randomized Clinical TrialFernanda Andrade Orsi, Joseph Biedermann, Marieke Kruip, Felix Van Der Meer; Frits Rosendaal, Mettine Bos, Frank Leebeek, Suzanne Cannegieter, Willem Lijfering

 

C0077 An Italian Registry on Risk Factors for Venous Thromboembolism in Blood Donors Clinicaltrials. Gov: Nct03282747Elvira Grandone, Angelo Ostuni, Lazzaro Di Mauro, Nadia Coffetti, Anna Turrini; Giobatta Cavallero, Patrizia Vergura, Filomena Cappucci, Antonio De Laurenzo, Michela Villani, Nicola Di Renzo, Alberto Tosetto, Maurizio Margaglione

7

 

C0343 Venous Thromboembolism in Hospitalized Pediatric Patients: Generation of a Risk Model from a Single-Center Prospective Nested Case-Control StudyGiovanni Del Borrello, Giulia Maria Matta, Marta Baricco, Elena Giachetti, Chiara Maddaloni, Alice Viano, Paola Saracco

15.00-16.30 BASIC SCIENCE (II)

  Chairs: F. Bernardi (Italy) and V. Pengo (Italy)

  1. Clot structure/function 

R. Ariens (UK)

  2. Tissue factor/soluble tissue factor 

H. H. Versteeg (The Netherlands)

  3. Prothombim structure

N. Pozzi (Italy/USA)

  4. Bacterial Proteases & Thrombosis 

V. De Filippis (Italy)

16.30-17.30 DEBATES

  Chair: M. Paciaroni (Italy) and Sergio Coccheri (Italy)

  Criptogenic stroke and PFO closure (yes/no)

  YES H. Sievert (Germany)

NO A. Pezzini (Italy)

17:30-18:30 POSTER VIEWING IN POSTER AREA

VOLPI ROOM

09.00-11.00 VENOUS THROMBOEMBOLISM (I)

  Chairs: M. Huisman (The Netherlands) and W. Ageno (Italy)

  1. Stratification of patients with PE 

M Huisman (The Netherlands)

  2. Role of thrombolityc therapy 

S. Konstantinides (Germany)

  3. Role of NOACs 

G. Agnelli (Italy)   

  4. Home treatment of patients with PE 

G.Meyer (France)

11.00-11.30 COFFEE BREAK

11.00-13.00 VENOUS THROMBOEMBOLISM (II)

  Chairs: A. Visonà (Italy) and S. Sokolovic (Bosnia Herzegovina)

  1. The value of CT angiography for PE risk stratification

C. Beccattini (Italy)

  2. Impact of residual obstruction on late complications 

R. Pesavento (Italy)

  3. Prevention and treatment of CTEPH 

F. Piovella (Italy)

8

  4. Prevention of PTS 

A. ten Cate (The Netherlands)

13.00-14.00 LUNCH SYMPOSIUM - DAIICHI SANKYO ITALIA

The high risk patient: the results of the HOKUSAI VTE study sub analysis 

W. Ageno (Italy) 

The cancer patient: the results of the HOKUSAI VTE Cancer study 

P. Prandoni (Italy) 

14.00-15.00 ORAL PRESENTATIONS PLATELETS AND INFLAMMATION (7 MINUTES + 3 DISCUSSION) 

D. Varon (Israel) and I. Elalamy (France)

  C0334 Matrix Metalloproteinase-13 Is A Novel Regulator Of Platelet Activation And In Vivo Thrombus FormationStefania Momi, Manuela Sebastiano, Emanuela Falcinelli, Paolo Gresele

  C0010 Platelet Rescue By Macrophage Depletion In Obese Adamts13 Deficient Mice At Risk For TtpRoger Lijnen, Lotte Geys, Elien Roose, Karen Vanhoorelbeke

 

CC0276 Platelet Adhesion Under Flow Condition Is Significantly Affected By Hematocrit (Hct) Levels In Polycythemia Vera (Pv) PatientsSara Gamba, Alfonso Vignoli, Paola van der Meijden, Marina Marchetti, Cinzia Giaccherini, Frauke Swieringa, Hugo ten Cate, Guido Finazzi, Alessandro Rambaldi, Johan Heemskerk, Anna Falanga

  C0168 Fine Adjusting Regulation Of Fibrinolysis In Women With Some DisordersEugene Roitman, Andrey Momot, Marine Tanashyan, Alla Shabalina

 

C0347 Genetic Testing For Inherited Thrombophilia: 20 Years Of Experience In A University And Tertiary Care Centre Cláudia Vaz, Francisco Bischoff, Fátima Monteiro, Manuela Lopes, Filipe Vasconcelos, Pedro Bastos, Gilberto Tavares, Marina Ferreira, Ana Amorim, Maria Koch

 

C0181 Apolipoprotein C-Iii Is A Predictor Of Activated Factor Vii-Antithrombin Complex Levels: A New Link Between Plasma Lipids And Coagulation PathwayFederica Tosi, Marcello Baroni, Annalisa Castagna, Filippo Stefanoni, Francesca Pizzolo, Antonella Bassi, Patrizia Pattini, Barbara Lunghi, Domenico Girelli, Barry Woodhams, Francesco Bernardi, Oliviero Olivieri, Nicola Martinelli

15.00-16.30 NOVEL ANTITHROMBOTIC DRUGS

  Chairs: F. Violi (Italy) and A. Tselepis (Greece)

  1. Factor XII and XI inhibitors as novel therapeutic options 

H. Büller (The Netherlands)

  2. Old and new antiplatelet agents 

P. Gresele (Italy)

  3. Cellular activities of coagulation factors Xa and thrombin. Are there pleiotropic effects of DOACs?

A. Tselepis (Greece)  

16.30-17.30 DEBATES

  Chair: P. Prandoni (Italy) and M. Marietta (Italy)

  Thromboprophylaxis in arthroscopy or lower leg injury

  YES D. Imberti (Italy)  

  NO S.C. Cannegieter (The Netherlands)

17:30-18:30 POSTER VIEWING IN POSTER AREA

17:30 EMLTD GENERAL ASSEMBLY

9

SATURDAY, MAY 26 2018PERLA ROOM

09:00-11:00 MEDITERRANEAN DIET AND VASCULAR RISK PREVENTION

Chairs: L. Iacoviello (Italy) and R. Estruch (Spain)

1. Mediterranean diet and the risk for chronic degenerative disorders 

F. Sofi (Italy)

2. The role of polyphenol in the beneficial effect of mediterranean diet

R. Zamora-Ros (France)

3. The effect of Mediterranean diet in the intervention studies 

R. Estruch (Spain)

4. Who is adhering to Mediterranean diet at the time of crisis? The experience of Moli.sani project 

L. Iacoviello (Italy)

11.00-11.30 COFFEE BREAK

11.30-11.55 LECTURE

INTRODUCTION: M. MOIA (ITALY)

Research in haemostasis and thrombosis: a look to the future 

F. Rosendaal (The Netherlands)

11.55-12.20 UPDATE ON THE DIAGNOSIS OF PULMONARY EMBOLISM

H. Bounameaux (Switzerland)

12.20-13.50 AWARDED ORAL PRESENTATIONS (10 MINUTES + 5 DISCUSSION)

Chairs: V. Pengo (Italy) and P. Prandoni (Italy)

C0229 Adalimumab-Based Regimen Versus Dmards for the Treatment of Venous Thrombosis in Behçet SyndromeGiacomo Emmi, Antonio Vitale, Elena Silvestri, Maria Boddi, Gerardo Di Scala, Augusto Vaglio, Luca Cantarini, Domenico Prisco

C0064 Differential Effects of Dabigatran and Rivaroxaban on FibrinolysisSuzanne Zwaveling, Saartje Bloemen, Joke Konings, Hilde Kelchtermans, Coenraad Hemker, Adam Miszta, Bas De Laat

C0195 State of Microcirculatory and Hemostasis Systems in Rats After Moderate HypothermiaNatalia Lycheva Alexandrovna

C0148 Variations in Mean Platelet Volume in Patients with Helicobacter Pylori Infection Before and After Eradication, Way Before Immune Thrombocytopenia?Burcu Dag, Elif Umit, Hasan Umit

C0144 Ticagrelor Inhibits the Platelet-Mediated Inflammatory ResponsesAikaterini N. Tsouka, Kenny M. Hansson, Alexandros D. Tselepis

C0136 Two Novel Variants of the Abcg5 Gene Cause Xanthelasmas and Macrothrombocytopenia; Review of Hematological Abnormalities Related to SitosterolemiaJose Maria Bastida, Rocio Benito, Kamila Janusz, Maria Luisa Giros, Jesus Maria Hernández-Sánchez, Maria Díez-Campelo, Shally Marcellini, Ana Hortal, Susana Riesco, Ana Rodriguez, Miguel Quijada, Maria Luisa Lozano, Jose Rivera, Jesus Maria Hernandez-Rivas, Jose Ramon Gonzalez-Porras

13.50-14.00 INTRODUCING THE 26TH INTERNATIONAL CONGRESS ON THROMBOSIS

A. TSELEPIS (GREECE)

14.00-14.30 AWARD CEREMONY

Chairs: A.M. Demir (Turkey), President of EMLTD and Vittorio Pengo (Italy), President of the ICT 2018.

SPONSORS

Karger Hematology Titles

SickKids Handbook of Pediatric Thrombosis and Hemostasis2nd, revised and extended editionEditors: Blanchette, V.S.; Brandão, L.R. (Toronto, Ont.); Breakey, V.R. (Hamilton, Ont.); Revel-Vilk, S. (Jerusalem)XX + 338 p., 31 fig., 13 in color, 80 tab., hardcover, 2017CHF 127.00 / EUR 119.00 / USD 149.00ISBN 978–3–318–03026–6

www.karger.com/sickkids

Editor: P. Ranaani (Petah Tikva)

www.karger.com/aha

Editor: P. Schlenke (Graz)

www.karger.com/tmh

BMA Medical Book Awards 2017: ‘highly commended’ in Paediatrics

A single source for international hematology research and clinical practice since 1948

Interdisciplinary journal for transfusion medicine, hemotherapy, immunohematology, and clinical hemostasis

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224

PLATINUM SPONSOR

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SPONSORS

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For more information, please visit:WWW.DAIICHI-SANKYO.EU

DS_Ad_4_EU_A4_4c_170131_fa.indd 1 1/31/17 11:50 AM

BIENNIAL

INTERNATIONAL

CONGRESS ON THROMBOSIS

MAY 23-26, 2018Palazzo del Casino

Venice Convention Center

VENICE-ITALY

GESTIÓN DE CONGRESOS Y SOCIEDADES

TECHNICAL SECRETARIATT 34 93 221 22 42 ww.geyseco.es - [email protected]

www.thrombosis2018.org

EUROPEAN BOARD FOR ACCREDITATION IN CARDIOLOGY

EBAC STANDARD TEXT ON ACCREDITATION

This text should be placed together with the EBAC logo on promotional/ printed materials concerning the accredited programme:

„The 25th International Congress on Thrombosis is accredited by the European Board for Accreditation in Cardiology (EBAC) for “number of hours” hours of External CME credits.

Each participant should claim only those hours of credit that have actually been spent in the educational activity.