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立体定向放射治疗在I期小细胞肺癌中的应用

Stereotactic Radiotherapy for Stage I Small Cell Lung Cancer

Vivek Verma Charles B Simone II Weining ZhenThe Oncologist 2016 21131-133 first published on January 13 2016 doi101634theoncologist2015-0348httptheoncologistalphamedpressorgcontent212131fullpdfzh+html

Pinedo Prize Lecture Genomic Profiling in Gastrointestinal Cancer Are We Ready To Use These Data to Make Treatment Decisions

Richard M GoldbergThe Oncologist 2015 201448-1456 first published on October 28 2015 doi101634theoncologist2015-0263httptheoncologistalphamedpressorgcgicontentabstract20121448

Breast cancer Prospective Biomarker Analysis of the Randomized CHER-LOB Study Evaluating the Dual Anti-HER2 Treatment With Trastuzumab and Lapatinib Plus Chemotherapy as Neoadjuvant Therapy for HER2-Positive Breast Cancer

Valentina Guarneri Maria Vittoria Dieci Antonio Frassoldati Antonino Maiorana Guido Ficarra Stefania Bettelli Enrico Tagliafico Silvio Bicciato Daniele Giulio Generali Katia Cagossi Giancarlo Bisagni Samanta Sarti Antonino Musolino Catherine Ellis Rocco Crescenzo and PierFranco ConteThe Oncologist 2015 201001-1010 first published on August 5 2015 doi101634theoncologist2015-0138httptheoncologistalphamedpressorgcgicontentabstract2091001

Breast cancer Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer

Libero Santarpia Giulia Bottai Catherine M Kelly Balaacutezs Győrffy Borbala Szeacutekely Lajos PusztaiThe Oncologist first published on July 6 2016 doi101634theoncologist2015-0369 httptheoncologistalphamedpressorgcontentearly20160706theoncologist2015-0369abstract

cancer diagnostics and MoLecuLar PathoLogy Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations

Siraj M Ali Sumanta K Pal Kai Wang Norma A Palma Eric Sanford Mark Bailey Jie He Julia A Elvin Juliann Chmielecki Rachel Squillace Edward Dow Deborah Morosini Jamie Buell Roman Yelensky Doron Lipson Garrett M Frampton Peter Howley Jeffrey S Ross Philip J Stephens and Vincent A MillerThe Oncologist 2016 2133-39 first published on December 15 2015 doi101634theoncologist2015-0241httptheoncologistalphamedpressorgcgicontentabstract21133

cancer diagnostics and MoLecuLar PathoLogy Picoliter-Droplet Digital Polymerase Chain Reaction-Based Analysis of Cell-Free Plasma DNA to Assess EGFR Mutations in Lung Adenocarcinoma That Confer Resistance to Tyrosine-Kinase Inhibitors

Yoshitaka Seki Yutaka Fujiwara Takashi Kohno Erina Takai Kuniko Sunami Yasushi Goto Hidehito Horinouchi Shintaro Kanda Hiroshi Nokihara Shun-ichi Watanabe Hitoshi Ichikawa Noboru Yamamoto Kazuyoshi Kuwano Yuichiro OheThe Oncologist 2016 21156-164 first published on January 14 2016 doi101634theoncologist2015-0288httptheoncologistalphamedpressorgcontent212156abstract

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2 Best of The Oncologist

gastrointestinaL cancer Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences

Kai Wang Adrienne Johnson Siraj M Ali Samuel J Klempner Tanios Bekaii-Saab Jeffrey L Vacirca Depinder Khaira Roman Yelensky Juliann Chmielecki Julia A Elvin Doron Lipson Vincent A Miller Philip J Stephens and Jeffrey S RossThe Oncologist 2015 201132-1139 first published on September 2 2015 doi101634theoncologist2015-0156httptheoncologistalphamedpressorgcgicontentfull20101132

Lung cancer Molecular Testing for Treatment of Metastatic Non-Small Cell Lung Cancer How to Implement Evidence-Based Recommendations

Benjamin P Levy Marc D Chioda Dana Herndon John W Longshore Mohamed Mohamed Sai-Hong Ignatius Ou Craig Reynolds Jaspal Singh Ignacio I Wistuba Paul A Bunn Jr and Fred R HirschThe Oncologist 2015 201175-1181 first published on September 1 2015 doi101634theoncologist2015-0114httptheoncologistalphamedpressorgcgicontentabstract20101175

Lung Cancer Comprehensive Genomic Profiling Facilitates Implementation of the National Comprehensive Cancer Network Guidelines for Lung Cancer Biomarker Testing and Identifies Patients Who May Benefit From Enrollment in Mechanism-Driven Clinical TrialsJames H Suh Adrienne Johnson Lee Albacker Kai Wang Juliann Chmielecki Garrett Frampton Laurie Gay Julia A Elvin Jo-Anne Vergilio Siraj Ali Vincent A Miller Philip J Stephens Jeffrey S RossThe Oncologist 2016 21684-691 first published on May 5 2016 doi101634theoncologist2016-0030httptheoncologistalphamedpressorgcontent216684abstract

new drug deveLoPMent and cLinicaL PharMacoLogy Bringing Model-Based Prediction to Oncology Clinical Practice A Review of Pharmacometrics Principles and ApplicationsNuacuteria Buil-Bruna Joseacute-Mariacutea Loacutepez-Picazo Salvador Martiacuten-Algarra Intildeaki F TrocoacutenizThe Oncologist 2016 21220-232 first published on December 14 2015 doi101634theoncologist2015-0322 httptheoncologistalphamedpressorgcontent212220abstract

new drug deveLoPMent and cLinicaL PharMacoLogy Chimeric Antigen Receptor T-Cell Therapy for the Community OncologistMarcela V Maus Bruce L LevineThe Oncologist 2016 21608-617 first published on March 23 2016 doi101634theoncologist2015-0421httptheoncologistalphamedpressorgcontent215608abstract

gLoBaL heaLth and cancer Exploring Knowledge Attitudes and Practices Related CME to Breast and Cervical Cancers in Mongolia A National Population-Based SurveyPooja Yerramilli Otgonduya Dugee Palam Enkhtuya Felicia M Knaul Alessandro R DemaioThe Oncologist 2015 201266-1273 first published on September 28 2015 doi101634theoncologist2015-0119httptheoncologistalphamedpressorgcontent20111266abstract

gLoBaL heaLth and cancer Distance as a Barrier to Cancer Diagnosis and Treatment CME Review of the Literature Massimo Ambroggi Claudia Biasini Cinzia Del Giovane Fabio Fornari Luigi Cavanna The Oncologist 2015 201378-1385 first published on October 28 2015 doi101634theoncologist2015-0110httptheoncologistalphamedpressorgcontent20121378abstract

中国乳腺恶性肿瘤根治术治疗方法的演变趋势为期10年的回顾性多中心研究gLoBaL heaLth and cancer Trends of Radical Surgical Treatment Methods for Breast Malignancies in China A Multicenter 10-Year Retrospective Review

Bai-Lin Zhang Priya G Sivasubramaniam Qian Zhang Jing Wang Bin Zhang Ji-Dong Gao Zhong-Hua Tang Guo-Ji Chen Xiao-Ming Xie Zhongzhao Wang Hong-Jian Yang Jian-Jun He Hui Li Jia-Yuan Li Jin-Hu Fan Xiang Wang You-Lin QiaoThe Oncologist 2015 201036-1043 first published on August 7 2015 doi101634theoncologist2014-0281httptheoncologistalphamedpressorgcontent2091036abstractzh

Abstracts 3

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中国乳腺癌治疗观念和实践的转变

coMMentary Changing Beliefs and Practices in Women with Breast Cancer in China

Michele A GaddThe Oncologist 2015 20979-980 first published on August 7 2015 doi101634theoncologist2015-0249httptheoncologistalphamedpressorgcontent209979fullpdfzh+html

Academia-Pharma Intersect Lung Cancer

免疫治疗在小细胞肺癌治疗中的前景

The Future of Immunotherapy in the Treatment of Small Cell Lung Cancer

Leora Horn Martin Reck David R SpigelThe Oncologist 2015 21910-921 first published on June 27 2015 doi101634theoncologist2015-0523httptheoncologistalphamedpressorgcontent218910abstractzh

Breast Cancer

接受二甲双胍治疗的糖尿病乳腺癌患者生存更佳meta分析

Metformin Use Is Associated With Better Survival of Breast Cancer Patients With Diabetes A Meta-Analysis

Hong Xu Kai Chen Xiaoyan Jia Yali Tian Yun Dai Dapeng Li Jing Xie Min Tao Yixiang MaoThe Oncologist 2015 201236-1244 first published on October 7 2015 doi101634theoncologist2015-0096httptheoncologistalphamedpressorgcontent20111236abstractzh

乳腺癌脑转移的多学科治疗诊所北卡罗来纳大学的经验

A Multidisciplinary Breast Cancer Brain Metastases Clinic CME The University of North Carolina Experience

Megan J McKee Kevin Keith Allison M Deal Amy L Garrett Amy A Wheless Rebecca L Green Julie M Benbow E Claire Dees Lisa A Carey Matthew G Ewend Carey K Anders Timothy M ZagarThe Oncologist 2016 2116-20 first published on December 9 2015 doi101634theoncologist2015-0328 httptheoncologistalphamedpressorgcontent21116abstractzh

在接受新辅助系统治疗联合曲妥珠单抗的HER2过表达局部晚期乳腺癌患者中高HER217号染色体着丝粒探针原位荧光杂交比值可预测病理学完全缓解和生存转归

High HER2Centromeric Probe for Chromosome 17 Fluorescence In Situ Hybridization Ratio Predicts Pathologic Complete Response and Survival Outcome in Patients Receiving Neoadjuvant Systemic Therapy With Trastuzumab for HER2-Overexpressing Locally Advanced Breast Cancer

Takahiro Kogawa Tamer M Fouad Diane D Liu Jimin Wu Yu Shen Hiroko Masuda Takeo Fujii Mariana Chavez-MacGregor Ricardo H Alvarez Gabriel N Hortobaacutegyi Vicente Valero Naoto T UenoThe Oncologist 2016 2121-27 first published on December 9 2015 doi101634theoncologist2015-0101httptheoncologistalphamedpressorgcontent21121abstractzh

乳腺神经内分泌癌现有证据与未来展望

Neuroendocrine Carcinoma of the Breast Current Evidence and Future Perspectives CME

Alessandro Inno Giuseppe Bogina Monica Turazza Laura Bortesi Simona Duranti Alberto Massocco Giuseppe Zamboni Giovanni Carbognin Filippo Alongi Matteo Salgarello Stefania GoriThe Oncologist 2016 2128-32 first published on December 9 2015 doi101634theoncologist2015-0309httptheoncologistalphamedpressorgcontent21128abstractzh

Abstracts

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他莫昔芬在乳腺导管内原位癌中的起始治疗

Tamoxifen Initiation After Ductal Carcinoma In Situ

Hazel B Nichols Erin JA Bowles Jessica Islam Lawrence Madziwa Til Stuumlrmer Diem-Thy Tran Diana SM BuistThe Oncologist 2016 21134-140 first published on January 14 2016 doi101634theoncologist2015-0310httptheoncologistalphamedpressorgcontent212134abstractzh

接受含蒽环类方案辅助化疗的乳腺癌患者的心室-动脉偶联

Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy

Graeme J Koelwyn Nia C Lewis Susan L Ellard Lee W Jones Jinelle C Gelinas J Douglass Rolf Bernie Melzer Samantha M Thomas Pamela S Douglas Michel G Khouri Neil D EvesThe Oncologist 2016 21141-149 first published on January 13 2016 doi101634theoncologist2015-0352httptheoncologistalphamedpressorgcontent212141abstractzh

高增殖预测早期乳腺癌新辅助化疗的病理学完全缓解

High Proliferation Predicts Pathological Complete Response to Neoadjuvant Chemotherapy in Early Breast Cancer

Emilio Alba Ana Lluch Nuria Ribelles Antonio Anton-Torres Pedro Sanchez-Rovira Joan Albanell Lourdes Calvo Jose Antonio Lopez Garciacutea-Asenjo Jose Palacios Jose Ignacio Chacon Amparo Ruiz Juan De la Haba-Rodriguez Miguel A Segui-Palmer Beatriz Cirauqui Mireia Margeli Arrate Plazaola Agusti Barnadas Maribel Casas Rosalia Caballero Eva Carrasco Federico RojoThe Oncologist 2016 21150-155 first published on January 19 2016 doi101634theoncologist2015-0312httptheoncologistalphamedpressorgcontent212150abstractzh

肿瘤浸润性淋巴细胞在不同疾病亚型的早期乳腺癌预测和预后中的作用辅助和新辅助治疗随机临床试验的敏感性分析

Predictive and Prognostic Role of Tumor-Infiltrating Lymphocytes for Early Breast Cancer According to Disease Subtypes Sensitivity Analysis of Randomized Trials in Adjuvant and Neoadjuvant Setting

Luisa Carbognin Sara Pilotto Rolando Nortilli Matteo Brunelli Alessia Nottegar Isabella Sperduti Diana Giannarelli Emilio Bria Giampaolo TortoraThe Oncologist 2016 21283-291 first published on February 10 2016 doi101634theoncologist2015-0307httptheoncologistalphamedpressorgcontent213283abstractzh

肥胖与乳腺癌分子内在联系及潜在临床应用

Obesity and Breast Cancer Molecular Interconnections and Potential Clinical Applications

Valeria Simone Morena DrsquoAvenia Antonella Argentiero Claudia Felici Francesca Maria Rizzo Giovanni De Pergola Franco SilvestrisThe Oncologist 2016 21404-417 first published on February 10 2016 doi101634theoncologist2015-0351httptheoncologistalphamedpressorgcontent214404abstractzh

紫杉醇联合曲妥珠单抗与帕妥珠单抗治疗HER2阳性转移性乳腺癌患者的心脏安全性

Cardiac Safety of Paclitaxel Plus Trastuzumab and Pertuzumab in Patients With HER2-Positive Metastatic Breast Cancer

Anthony F Yu Carlos Manrique Shawn Pun Jennifer E Liu Elton Mara Martin Fleisher Sujata Patil Lee W Jones Richard M Steingart Clifford A Hudis Chau T DangThe Oncologist 2016 21418-424 first published on March 16 2016 doi101634theoncologist2015-0321httptheoncologistalphamedpressorgcontent214418abstractzh

Abstracts 5


接受骨调节剂治疗的乳腺癌骨转移患者发生骨骼相关事件的危险因素

Risk Factors for Developing Skeletal-Related Events in Breast Cancer Patients With Bone CME Metastases Undergoing Treatment With Bone-Modifying Agents

Ryota Tanaka Kan Yonemori Akihiro Hirakawa Fumie Kinoshita Naoki Takahashi Jun Hashimoto Makoto Kodaira Harukaze Yamamoto Mayu Yunokawa Chikako Shimizu Manabu Fujimoto Yasuhiro Fujiwara Kenji TamuraThe Oncologist 2016 21508-513 first published on March 14 2016 doi101634theoncologist2015-0377httptheoncologistalphamedpressorgcontent214508abstractzh

接受芳香化酶抑制剂治疗的绝经后早期乳腺癌女性的患者报告转归与早期停药

Patient-Reported Outcomes and Early Discontinuation in Aromatase Inhibitor-Treated Postmenopausal Women With Early Stage Breast Cancer

Kunal C Kadakia Claire F Snyder Kelley M Kidwell Nicholas J Seewald David A Flockhart Todd C Skaar Zereunesay Desta James M Rae Julie L Otte Janet S Carpenter Anna M Storniolo Daniel F Hayes Vered Stearns N Lynn HenryThe Oncologist 2016 21539-546 first published on March 23 2016 doi101634theoncologist2015-0349httptheoncologistalphamedpressorgcontent215539abstractzh

接受曲妥珠单抗辅助治疗的早期乳腺癌患者发生充血性心力衰竭的风险Meta分析

Risk of Congestive Heart Failure in Early Breast Cancer Patients Undergoing Adjuvant Treatment With Trastuzumab A Meta-Analysis

Hui-Dong Long Yun-En Lin Juan-Juan Zhang Wen-Zhao Zhong Rui-Nian ZhengThe Oncologist 2016 21547-554 first published on March 29 2016 doi101634theoncologist2015-0424httptheoncologistalphamedpressorgcontent215547abstractzh

荷兰临床实践中曲妥珠单抗辅助治疗过程中的心脏毒性和心脏监测荷兰东南部乳腺癌联盟研究

Cardiotoxicity and Cardiac Monitoring During Adjuvant Trastuzumab in Daily Dutch Practice A Study of the Southeast Netherlands Breast Cancer Consortium

Shanly C Seferina Maaike de Boer M Wouter Derksen Franchette van den Berkmortel Roel JW van Kampen Agnegraves J van de Wouw Manuela Joore Petronella GM Peer Adri C Voogd Vivianne CG Tjan-HeijnenThe Oncologist 2016 21555-562 first published on March 23 2016 doi101634theoncologist2015-0230 httptheoncologistalphamedpressorgcontent215555abstractzh

基线心功能筛查在早期乳腺癌治疗中的用途评价

Evaluating the Utility of Baseline Cardiac Function Screening in Early-Stage Breast Cancer Treatment

Sandy R Truong William T Barry Javid J Moslehi Emily L Baker Erica L Mayer Ann H PartridgeThe Oncologist 2016 21666-670 first published on April 22 2016 doi101634theoncologist2015-0449httptheoncologistalphamedpressorgcontent216666abstractzh

Gastrointestinal Cancer

家族性胃癌

Familial Gastric Cancers CME

Namrata Setia Jeffrey W Clark Dan G Duda Theodore S Hong Eunice L Kwak John T Mullen Gregory Y LauwersThe Oncologist 2015 201365-1377 first published on September 30 2015 doi101634theoncologist2015-0205httptheoncologistalphamedpressorgcontent20121365abstractzh

TheOncologistreg




当前对临界可切除胰腺癌和不可切除的局部进展期胰腺癌的管理

Contemporary Management of Borderline Resectable and Locally Advanced Unresectable Pancreatic Cancer

Walid L Shaib Andrew Ip Kenneth Cardona Olatunji B Alese Shishir K Maithel David Kooby Jerome Landry Bassel F El-RayesThe Oncologist 2016 21178-187 first published on February 1 2016 doi101634theoncologist2015-0316httptheoncologistalphamedpressorgcontent212178abstractzh

奥曲肽LAR剂量与晚期神经内分泌肿瘤老年患者的生存

Octreotide LAR Dosage and Survival Among Elderly Patients With Distant-Stage Neuroendocrine Tumors

Chan Shen Ying Xu Arvind Dasari Ya-Chen Tina Shih James C YaoThe Oncologist 2016 21308-313 first published on February 24 2016 doi101634theoncologist2015-0381httptheoncologistalphamedpressorgcontent213308abstractzh

结直肠癌幸存者健康相关生活质量的备选预测因素系统综述

Candidate Predictors of Health-Related Quality of Life of Colorectal Cancer Survivors A Systematic Review

Martijn JL Bours Bernadette WA van der Linden Renate M Winkels Fraumlnzel J van Duijnhoven Floortje Mols Eline H van Roekel Ellen Kampman Sandra Beijer Matty P WeijenbergThe Oncologist 2016 21433-452 first published on February 24 2016 doi101634theoncologist2015-0258httptheoncologistalphamedpressorgcontent214433abstractzh

妊娠期结直肠癌的治疗细胞毒化疗与靶向治疗的挑战

The Treatment of Colorectal Cancer During Pregnancy Cytotoxic Chemotherapy and Targeted Therapy Challenges

Jane E Rogers Arvind Dasari Cathy EngThe Oncologist 2016 21563-570 first published on March 21 2016 doi101634theoncologist2015-0362httptheoncologistalphamedpressorgcontent215563abstractzh

结直肠癌错配修复状态对辅助化疗治疗决策的影响基于人群的澳大利亚多中心研究

The Impact of Mismatch Repair Status in Colorectal Cancer on the Decision to Treat With CME Adjuvant Chemotherapy An Australian Population-Based Multicenter Study

Emily Y He Nicholas J Hawkins Gabriel Mak Felicia Roncolato David Goldstein Winston Liauw Philip Clingan Melvin Chin Robyn L WardThe Oncologist 2016 21618-625 first published on March 23 2016 doi101634theoncologist2015-0530httptheoncologistalphamedpressorgcontent215618abstractzh

乳腺癌的差异中国与美国肿瘤诊断特征和手术治疗的多中心比较

Breast Cancer Disparities A MultiCenter Comparison Between Tumor Diagnosis CME Characteristics and Surgical Treatment in China and the US

Priya G Sivasubramaniam Bai-Lin Zhang Qian Zhang Jennifer S Smith Bin Zhang Zhong-Hua Tang Guo-Ji Chen Xiao-Ming Xie Xiao-Zhou Xu Hong-Jian Yang Jian-Jun He Hui Li Jia-Yuan Li Jin-Hu Fan You-Lin QiaoThe Oncologist 2015 201044-1050 first published on August 3 2015 doi101634theoncologist2014-0290httptheoncologistalphamedpressorgcontent2091044abstractzh

Abstracts 7


评价careHPVCervista人乳头瘤病毒检测及第二代杂交捕获法在诊断新疆维吾尔族妇女宫颈上皮内瘤变2级及以上级别病变中的应用

Evaluation of careHPV Cervista Human Papillomavirus and Hybrid Capture 2 Methods in Diagnosing Cervical Intraepithelial Neoplasia Grade 2+ in Xinjiang Uyghur Women

Gulixian Tuerxun Awaguli Yukesaier Ling Lu Kailibinuer Aierken Patiman Mijiti Yujie Jiang Axianguli Abulizi Yuanyuan Zhang Guzhanuer Abuduxikuer Guzhalinuer Abulizi Hua LiThe Oncologist 2016 21825-831 first published on June 17 2016 doi101634theoncologist2015-0447httptheoncologistalphamedpressorgcontent217825abstractzh

RAS和BRAF野生型转移性结直肠癌患者的原发肿瘤病灶部位与抗表皮生长因子受体单克隆抗体治疗的获益

Location of Primary Tumor and Benefit From Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies in Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer

Roberto Moretto Chiara Cremolini Daniele Rossini Filippo Pietrantonio Francesca Battaglin Alessia Mennitto Francesca Bergamo Fotios Loupakis Federica Marmorino Rosa Berenato Valentina Angela Marsico Marta Caporale Carlotta Antoniotti Gianluca Masi Lisa Salvatore Beatrice Borelli Gabriella Fontanini Sara Lonardi Filippo De Braud Alfredo Falcone The Oncologist 2016 21988-994 first published on July 5 2016 doi101634theoncologist2016-0084httptheoncologistalphamedpressorgcontent218988abstractzh

Gynecologic Oncology

2型糖尿病对亚洲早期子宫颈癌患者预后的影响

The Prognostic Impact of Type 2 Diabetes Mellitus on Early Cervical Cancer in Asia CME

Hung-Yang Kuo Zhong-Zhe Lin Raymond Kuo Wen-Yi Shau Chiu-Lin Lai Yen-Yun Yang Yu-Yun Shao Chiun Hsu Wen-Fan Cheng Ann-Lii Cheng James Chih-Hsin Yang Mei-Shu LaiThe Oncologist 2015 201051-1057 first published on August 3 2015 doi101634theoncologist2015-0111httptheoncologistalphamedpressorgcontent2091051abstractzh

Hepatobiliary

索拉非尼联合或不联合动脉化疗栓塞治疗晚期肝细胞癌合并门静脉主干癌栓回顾性分析

Sorafenib With and Without Transarterial Chemoembolization for Advanced Hepatocellular Carcinoma With Main Portal Vein Tumor Thrombosis A Retrospective Analysis

Yingqiang Zhang Wenzhe Fan Yu Wang Ligong Lu Sirui Fu Jianyong Yang Yonghui Huang Wang Yao Jiaping LiThe Oncologist 2015 201417-1424 first published on October 7 2015 doi101634theoncologist2015-0196httptheoncologistalphamedpressorgcontent20121417abstractzh

纤维板层型肝细胞癌相关性高氨血症性脑病案例报告文献综述与建议治疗方案

Hyperammonemic Encephalopathy Associated With Fibrolamellar Hepatocellular Carcinoma CME Case Report Literature Review and Proposed Treatment Algorithm

Claudia I Chapuy Inderneel Sahai Rohit Sharma Andrew X Zhu Olga N KozyrevaThe Oncologist 2016 21514-520 first published on March 14 2016 doi101634theoncologist2015-0267httptheoncologistalphamedpressorgcontent214514abstractzh

TheOncologistreg




美国40年间胆管癌的发病率变化趋势肝内病变的发病率正在升高

Forty-Year Trends in Cholangiocarcinoma Incidence in the US Intrahepatic Disease on the Rise

Supriya K Saha Andrew X Zhu Charles S Fuchs Gabriel A BrooksThe Oncologist 2016 21594-599 first published on March 21 2016 doi101634theoncologist2015-0446httptheoncologistalphamedpressorgcontent215594abstractzh

结直肠癌肝转移肝切除术后的早期复发最佳定义是什么预测因素又是什么

Early Recurrence After Hepatectomy for Colorectal Liver Metastases CME What Optimal Definition and What Predictive Factors

Katsunori Imai Marc-Antoine Allard Carlos Castro Benitez Eric Vibert Antonio Sa Cunha Daniel Cherqui Denis Castaing Henri Bismuth Hideo Baba Reneacute AdamThe Oncologist 2016 21887-894 first published on April 28 2016 doi101634theoncologist2015-0468httptheoncologistalphamedpressorgcontent217887abstractzh

Lung Cancer

厄洛替尼应答的晚期非小细胞肺癌患者发生进展后继续厄洛替尼治疗的II期随机研究

Randomized Phase II Trial of Erlotinib Beyond Progression in Advanced Erlotinib-Responsive Non-Small Cell Lung Cancer

Balazs Halmos Nathan A Pennell Pingfu Fu Shumaila Saad Shirish Gadgeel Gregory A Otterson Tarek Mekhail Michael Snell J Philip Kuebler Neelesh Sharma Afshin DowlatiThe Oncologist 2015 201298-1303 first published on August 25 2015 doi101634theoncologist2015-0136httptheoncologistalphamedpressorgcontent20111298abstractzh

表皮生长因子受体抑制剂在肺鳞癌治疗中的作用

Epidermal Growth Factor Receptor Inhibition in the Management of Squamous Cell Carcinoma of the Lung

Glenwood D Goss Johanna N SpaansThe Oncologist 2016 21205-213 first published on January 14 2016 doi101634theoncologist2015-0209httptheoncologistalphamedpressorgcontent212205abstractzh

非小细胞肺癌中的MET外显子14跳读

MET Exon 14 Skipping in Non-Small Cell Lung Cancer

Rebecca S Heist Hyo Sup Shim Shalini Gingipally Mari Mino-Kenudson Long Le Justin F Gainor Zongli Zheng Martin Aryee Junfeng Xia Peilin Jia Hailing Jin Zhongming Zhao William Pao Jeffrey A Engelman A John IafrateThe Oncologist 2016 21481-486 first published on March 28 2016 doi101634theoncologist2015-0510httptheoncologistalphamedpressorgcontent214481abstractzh

在疾病进展的新时代中重新评估疾病进展间变性淋巴瘤激酶阳性非小细胞肺癌的一线和二线治疗综述

Re-Evaluating Progression in an Era of Progress A Review of First- and Second-Line CME Treatment Options in Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer

Emily H Castellanos Leora HornThe Oncologist 2016 21755-761 first published on April 6 2016 doi101634theoncologist2015-0396httptheoncologistalphamedpressorgcontent216755abstractzh

Abstracts 9


综合性基因组分析可鉴别出荧光原位杂交检验未测出的对克唑替尼治疗有应答的ALK重排非小细胞肺癌患者亚组

Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive CME ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization

Siraj M Ali Thomas Hensing Alexa B Schrock Justin Allen Eric Sanford Kyle Gowen Atul Kulkarni Jie He James H Suh Doron Lipson Julia A Elvin Roman Yelensky Zachary Chalmers Juliann Chmielecki Nir Peled Samuel J Klempner Kashif Firozvi Garrett M Frampton Julian R Molina Smitha Menon Julie R Brahmer Heber MacMahon Jan Nowak Sai-Hong Ignatius Ou Marjorie Zauderer Marc Ladanyi Maureen Zakowski Neil Fischbach Jeffrey S Ross Phil J Stephens Vincent A Miller Heather Wakelee Shridar Ganesan Ravi SalgiaThe Oncologist 2016 21762-770 first published on May 31 2016 doi101634theoncologist2015-0497httptheoncologistalphamedpressorgcontent216762abstractzh

Melanoma and Cutaneous Malignancies

循环肿瘤细胞DNA和mRNA在黑色素瘤患者中潜在的临床应用

Circulating Tumor Cells DNA and mRNA CME Potential for Clinical Utility in Patients With Melanoma

Melody J Xu Jay F Dorsey Ravi Amaravadi Giorgos Karakousis Charles B Simone II Xiaowei Xu Wei Xu Erica L Carpenter Lynn Schuchter Gary D KaoThe Oncologist 2016 2184-94 first published on November 27 2015 doi101634theoncologist2015-0207httptheoncologistalphamedpressorgcontent21184abstractzh

Radiation Oncology

立体定向放射治疗联合酪氨酸激酶抑制剂用于治疗癌基因驱动的IV期肺癌

Integration of Stereotactic Body Radiation Therapy With Tyrosine Kinase Inhibitors in Stage IV Oncogene-Driven Lung Cancer

Meghan Campo Hani Al-Halabi Melin Khandekar Alice T Shaw Lecia V Sequist Henning WillersThe Oncologist 2015 201216-1222 first published on September 4 2015 doi101634theoncologist2015-0178httptheoncologistalphamedpressorgcontent20101216abstractzh

Symptom Management and Supportive Care

步行-饮食干预可改善接受新辅助放化疗的食道癌患者的转归

A Walk-and-Eat Intervention Improves Outcomes for Patients With Esophageal CME Cancer Undergoing Neoadjuvant Chemoradiotherapy

Yu-Juan Xu Jason Chia-Hsien Cheng Jang-Ming Lee Pei-Ming Huang Guan-Hua Huang Cheryl Chia-Hui ChenThe Oncologist 2015 201216-1222 first published on September 4 2015 doi101634theoncologist2015-0178httptheoncologistalphamedpressorgcontent20101216abstractzh

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西妥昔单抗联合多西他赛和顺铂用于不可切除的局部晚期头颈癌患者诱导化疗的随机多中心II期研究

A Randomized Multicenter Phase II Study of Cetuximab With Docetaxel and Cisplatin as Induction Chemotherapy in Unresectable Locally Advanced Head and Neck Cancer

Keun-Wook Lee Youngil Koh Sung-Bae Kim Sang-Won Shin Jin-Hyoung Kang Hong-Gyun Wu Myung-Whun Sung Bhumsuk Keam Dong-Wan Kim Tae Min Kim Kwang Hyun Kim Tack-Kyun Kwon J Hun Hah In-Ah Kim Soon-Hyun Ahn Dok Hyun Yoon Sang-Wook Lee Sang Yoon Kim Soon Yuhl Nam Kwang-Yoon Jung Seung-Kuk Baek Sook Hee Hong Se-Hoon Lee Dae Seog HeoThe Oncologist 2015 201119-1120 first published on August 24 2015 doi101634theoncologist2015-0208httptheoncologistalphamedpressorgcontent20101119abstractzh

首次应用于人体的概念验证研究黑色素瘤皮肤转移病灶内注射内皮素受体B拮抗剂BQ788

First-in-Human Proof-of-Concept Study Intralesional Administration of BQ788 an Endothelin Receptor B Antagonist to Melanoma Skin Metastases

Jasper Wouters Robert E Hunger Terence Garrod Benoit Dubuis Thomas Hunziker Joost J van den Oord Ronit Lahav-le CoutreThe Oncologist 2015 201121-1122 first published on September 1 2015 doi101634theoncologist2015-0139httptheoncologistalphamedpressorgcontent20101121abstractzh

吉西他滨与多西他赛联合帕唑帕尼用于软组织肉瘤新辅助治疗的IbII期研究

A Phase IbII Study of Gemcitabine and Docetaxel in Combination With Pazopanib for the Neoadjuvant Treatment of Soft Tissue Sarcomas

Rodrigo R Munhoz Sandra P DrsquoAngelo Mrinal M Gounder Mary L Keohan Ping Chi Richard D Carvajal Samuel Singer Aimee M Crago Jonathan Landa John H Healey Li-Xuan Qin Meera Hameed Marietta O Ezeoke Arun S Singh Mark Agulnik Bartosz Chmielowski Jason J Luke Brian A Van Tine Gary K Schwartz William D Tap Mark A DicksonThe Oncologist 2015 201245-1246 first published on October 8 2015 doi101634theoncologist2015-0245httptheoncologistalphamedpressorgcontent20111245abstractzh

替西罗莫司用于去势难治性前列腺癌多西他赛诱导治疗后的维持治疗

Temsirolimus Maintenance Therapy After Docetaxel Induction in Castration-Resistant Prostate Cancer

Urban Emmenegger Christopher M Booth Scott Berry Srikala S Sridhar Eric Winquist Nesan Bandali Annabelle Chow Christina Lee Ping Xu Shan Man Robert S Kerbel Yoo-Joung KoThe Oncologist 2015 201351-1352 first published on November 5 2015 doi101634theoncologist2015-0220httptheoncologistalphamedpressorgcontent20121351abstractzh

S0502SWOG伊马替尼联合或不联合贝伐珠单抗用于初治转移性或不可手术切除的胃肠道间质瘤患者III期随机临床研究

S0502 A SWOG Phase III Randomized Study of Imatinib With or Without Bevacizumab in Patients With Untreated Metastatic or Unresectable Gastrointestinal Stromal Tumors

Charles D Blanke Cathy Rankin Christopher Corless Janet F Eary Karen Mulder Scott H Okuno Suzanne George Michael HeinrichThe Oncologist 2015 201353-1354 first published on November 17 2015 doi101634theoncologist2015-0295httptheoncologistalphamedpressorgcontent20121353abstractzh

Clinical Trial Results

Clinical Trial Results 11


在仅有肝脏转移的转移性KRAS野生型结直肠癌患者中给予FOLFOXIRI联合帕尼单抗治疗后评价切除术情况的II期研究

A Phase II Study of FOLFOXIRI Plus Panitumumab Followed by Evaluation for Resection in Patients With Metastatic KRAS Wild-Type Colorectal Cancer With Liver Metastases Only

Johanna C Bendell Ahmed Zakari James D Peyton Ralph Boccia Mark Moskowitz Victor Gian Andrew Lipman David Waterhouse Richard LoCicero Chris Earwood Cassie M Lane Anthony MeluchThe Oncologist 2016 21279-280 first published on February 24 2016 doi101634theoncologist2015-0439httptheoncologistalphamedpressorgcontent213279abstractzh

贝伐珠单抗联合替莫唑胺用于一线治疗转移性葡萄膜黑色素瘤患者的II期临床试验

Phase II Trial of Bevacizumab in Combination With Temozolomide as First-Line Treatment in Patients With Metastatic Uveal Melanoma

Sophie Piperno-Neumann Alhassane Diallo Marie-Christine Etienne-Grimaldi Franccedilois-Cleacutement Bidard Manuel Rodrigues Corine Plancher Pascale Mariani Nathalie Cassoux Didier Decaudin Bernard Asselain Vincent ServoisThe Oncologist 2016 21281-282 first published on February 24 2016 doi101634theoncologist2015-0501httptheoncologistalphamedpressorgcontent213281abstractzh

II期研究中接受雷莫芦单抗治疗的晚期实体瘤患者的校正QT间期心电图特征

Electrocardiographic Characterization of Ramucirumab on the Corrected QT Interval in a Phase II Study of Patients With Advanced Solid Tumors

Anthony J Olszanski David C Smith Luis H Camacho John Thompson Suresh S Ramalingam R Donald Harvey Luis Campos David Ferry Shande Tang Ling Gao Howard SafranThe Oncologist 2016 21402-403 first published on March 16 2016 doi101634theoncologist2015-0467httptheoncologistalphamedpressorgcontent214402abstractzh

催乳素受体拮抗剂LFA102用于转移性乳腺癌和去势抵抗性前列腺癌的I期研究

Phase I Study of the Prolactin Receptor Antagonist LFA102 in Metastatic Breast and Castration-Resistant Prostate Cancer

Neeraj Agarwal Jean-Pascal Machiels Cristina Suaacuterez Nancy Lewis Michaela Higgins Kari Wisinski Ahmad Awada Michela Maur Mark Stein Andy Hwang Rebecca Mosher Ernesto Wasserman Gang Wu Hefei Zhang Renata Zieba Mohamed ElmeliegyThe Oncologist 2016 21535-536 first published on April 18 2016 doi101634theoncologist2015-0502httptheoncologistalphamedpressorgcontent215535abstractzh

顺铂替加氟尿嘧啶伊立替康三联方案用于治疗复发性转移性头颈鳞状细胞癌III期临床研究

CisplatinTegafurUracilIrinotecan Triple Combination Therapy for RecurrentMetastatic Head and Neck Squamous Cell Carcinoma A Phase III Clinical Study

San-Chi Chen Peter Mu-Hsin Chang Muh-Hwa YangThe Oncologist 2016 21537-538 first published on April 18 2016 doi101634theoncologist2015-0515httptheoncologistalphamedpressorgcontent215537abstractzh

来那度胺和索拉非尼用于晚期肝细胞癌患者的I期研究

Phase I Study of Lenalidomide and Sorafenib in Patients With Advanced Hepatocellular Carcinoma

Safi Shahda Patrick J Loehrer Romnee S Clark A John Spittler Sandra K Althouse E Gabriella ChioreanThe Oncologist 2016 21664-665 first published on June 2 2016 doi101634theoncologist2016-0071httptheoncologistalphamedpressorgcontent216664abstractzh

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组蛋白去乙酰化酶抑制剂帕比司他治疗低级别神经内分泌瘤的II期临床试验

A Phase II Trial of a Histone Deacetylase Inhibitor Panobinostat in Patients With Low-Grade Neuroendocrine Tumors

Ning Jin Sam J Lubner Daniel L Mulkerin Saurabh Rajguru Lakeesha Carmichael Herb Chen Kyle D Holen Noelle K LoConteThe Oncologist 2016 21785-786 first published on June 3 2016 doi101634theoncologist2016-0060 httptheoncologistalphamedpressorgcontent217785abstractzh

磷脂酰肌醇3激酶（PI3K）和哺乳动物雷帕霉素靶蛋白（mTOR）双重抑制剂BEZ235治疗晚期肾细胞癌患者的Ib期研究

A Phase Ib Study of BEZ235 a Dual Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) and Mammalian Target of Rapamycin (mTOR) in Patients With Advanced Renal Cell Carcinoma

Maria I Carlo Ana M Molina Yulia Lakhman Sujata Patil Kaitlin Woo John DeLuca Chung-Han Lee James J Hsieh Darren R Feldman Robert J Motzer Martin H VossThe Oncologist 2016 21787-788 first published on June 10 2016 doi101634theoncologist2016-0145 httptheoncologistalphamedpressorgcontent217785abstractzh

在大型肿瘤年会投稿的临床试验摘要的最终发表情况评估

Assessing the Eventual Publication of Clinical Trial Abstracts Submitted to a Large Annual Oncology Meeting

Paul R Massey Ruibin Wang Vinay Prasad Susan E Bates Tito FojoThe Oncologist 2016 21261-268 first published on February 17 2016 doi101634theoncologist2015-0516httptheoncologistalphamedpressorgcontent213261abstractzh

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gastrointestinaL cancer Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences

Kai Wang Adrienne Johnson Siraj M Ali Samuel J Klempner Tanios Bekaii-Saab Jeffrey L Vacirca Depinder Khaira Roman Yelensky Juliann Chmielecki Julia A Elvin Doron Lipson Vincent A Miller Philip J Stephens and Jeffrey S RossThe Oncologist 2015 201132-1139 first published on September 2 2015 doi101634theoncologist2015-0156httptheoncologistalphamedpressorgcgicontentfull20101132

Lung cancer Molecular Testing for Treatment of Metastatic Non-Small Cell Lung Cancer How to Implement Evidence-Based Recommendations

Benjamin P Levy Marc D Chioda Dana Herndon John W Longshore Mohamed Mohamed Sai-Hong Ignatius Ou Craig Reynolds Jaspal Singh Ignacio I Wistuba Paul A Bunn Jr and Fred R HirschThe Oncologist 2015 201175-1181 first published on September 1 2015 doi101634theoncologist2015-0114httptheoncologistalphamedpressorgcgicontentabstract20101175

Lung Cancer Comprehensive Genomic Profiling Facilitates Implementation of the National Comprehensive Cancer Network Guidelines for Lung Cancer Biomarker Testing and Identifies Patients Who May Benefit From Enrollment in Mechanism-Driven Clinical TrialsJames H Suh Adrienne Johnson Lee Albacker Kai Wang Juliann Chmielecki Garrett Frampton Laurie Gay Julia A Elvin Jo-Anne Vergilio Siraj Ali Vincent A Miller Philip J Stephens Jeffrey S RossThe Oncologist 2016 21684-691 first published on May 5 2016 doi101634theoncologist2016-0030httptheoncologistalphamedpressorgcontent216684abstract

new drug deveLoPMent and cLinicaL PharMacoLogy Bringing Model-Based Prediction to Oncology Clinical Practice A Review of Pharmacometrics Principles and ApplicationsNuacuteria Buil-Bruna Joseacute-Mariacutea Loacutepez-Picazo Salvador Martiacuten-Algarra Intildeaki F TrocoacutenizThe Oncologist 2016 21220-232 first published on December 14 2015 doi101634theoncologist2015-0322 httptheoncologistalphamedpressorgcontent212220abstract

new drug deveLoPMent and cLinicaL PharMacoLogy Chimeric Antigen Receptor T-Cell Therapy for the Community OncologistMarcela V Maus Bruce L LevineThe Oncologist 2016 21608-617 first published on March 23 2016 doi101634theoncologist2015-0421httptheoncologistalphamedpressorgcontent215608abstract

gLoBaL heaLth and cancer Exploring Knowledge Attitudes and Practices Related CME to Breast and Cervical Cancers in Mongolia A National Population-Based SurveyPooja Yerramilli Otgonduya Dugee Palam Enkhtuya Felicia M Knaul Alessandro R DemaioThe Oncologist 2015 201266-1273 first published on September 28 2015 doi101634theoncologist2015-0119httptheoncologistalphamedpressorgcontent20111266abstract

gLoBaL heaLth and cancer Distance as a Barrier to Cancer Diagnosis and Treatment CME Review of the Literature Massimo Ambroggi Claudia Biasini Cinzia Del Giovane Fabio Fornari Luigi Cavanna The Oncologist 2015 201378-1385 first published on October 28 2015 doi101634theoncologist2015-0110httptheoncologistalphamedpressorgcontent20121378abstract

中国乳腺恶性肿瘤根治术治疗方法的演变趋势为期10年的回顾性多中心研究gLoBaL heaLth and cancer Trends of Radical Surgical Treatment Methods for Breast Malignancies in China A Multicenter 10-Year Retrospective Review

Bai-Lin Zhang Priya G Sivasubramaniam Qian Zhang Jing Wang Bin Zhang Ji-Dong Gao Zhong-Hua Tang Guo-Ji Chen Xiao-Ming Xie Zhongzhao Wang Hong-Jian Yang Jian-Jun He Hui Li Jia-Yuan Li Jin-Hu Fan Xiang Wang You-Lin QiaoThe Oncologist 2015 201036-1043 first published on August 7 2015 doi101634theoncologist2014-0281httptheoncologistalphamedpressorgcontent2091036abstractzh

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