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Page 1: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

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Page 2: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

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DEPART.MEhT H E A L T H & HU,VAN SERVICES Public Health Service < .

National Institutes of Health National Cancer institute Bethesda, Maryland 20205

. . . . . I

March 23, 1984

Oui Reference: Interagency Agreement No. YO1-CP-90203

Department of Energy Oak Ridge Operations P . O . Box E Oak Ridge, TN 37830

A t ten t i on : Mr . W i l l i a m R. Bibb

Dear Mr . Bibb:

The above referenced interagency agreement expi red on February 28, 1982. We a re i n the process o f a d m i n i s t r a t i v e l y c l o s i n g out t h i s agreement. According t o our records, an unexpended balance o f $66.00 i s s t i l l remaining i n t h a t agreement.

We woul d l i k e t o deobl igate the unexpended funds and woul d apprec iate your o f f i c e conf i rm ing t h i s f i g u r e w i t h your records. Also, please i n f o r m us i f there a r e any unpaid expenses associates w i t h t h i s agreement.

I f add i t i ona l in format ion i s needed o r you have any quest ions please fee l f r e e to c a l l me on (301) 427-8888.

S i ncere ly ,

E l izabeth J . Osinski Contract ing O f f i c v

1 0 1 8 b 2 5

Page 3: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

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Page 4: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

Our Reference: Interdgency Agreement No. Y O 1 -CP-90203

UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830

Attention: Wi 1 1 i am R. Bibb Di rector, Research Division

Ladies and Gent1 ernen:

Performance of the subject interagency agreement was completed on February 28, 1982. To permit us t o close t h i s contract administra- t ive ly , i t i s requested t h a t the following documents be submitted within 30 days.

( 1 ) A s stated in Article IV, Pa rag raph B of our agreement, 4 copies of a f ina l report are required w i t h i n t h i r t y days of the expiration date. Please forward in accordance with the dis t r ibut ion called f o r in your agreement .

( 2 ) A S t a n d a r d Forn 1081, Voucher and Schedule of Withdrawals and Credits, fo r the final quarter, in sextupl icate , covering costs incurred for final quarter.

The above referenced report shall be submitted t o :

Contract Speci a1 i s t i‘4ational Cancer i n s t i t u t e d l a i r e u i l a i n g , Koon 2A07 National Inst i tutes of Health 9Wd Kockvi 1 l e Pike Bethesda, Mary1 a n d 20205

Si ncprely yours, A

Contracting ‘bfficer.1 Carci nogenesi s Contracts Sect ion Research Contracts Branch National Cancer Ins t i tu te

Page 5: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

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Page 6: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

O u r Eieference: I n t e r a g e n c y Agreement No. YO1-CP-90203 M o d i f i c a t i o n No. 2

Depar tmen t of Energy Oak Ridge O p e r a t i o n s P.O. Box E Oak Ridge , Tennessee 37830

A t t e n t i o n : W i l l i a m R. Bibb , D i r e c t o r Resea rch D i v i s i o n

Gent lemen:

W e are e n c l o s i n g an execu ted copy o f t h e s u b j e c t agreement f o r your r e t e n t i o n . I f you have any q u e s t i o n s r e g a r d i n g i t s a d a i n i s t r a t i o n c a l l t h i s o f f i c e (301) 4 2 7 - 8 7 7 1 o r w r i t e t o :

Rodol fo M. Reyes C o n t r a c t S p e c i a l i s t Research C o n t r a c t s Branch , CCS N a t i o n a l Cancer I n s t i t u t e S a t i o n a i I n s t i t u t e s o f H e a l t h B l a i r B u i l d i n g , Room 2A07 Beth?sda , Xary land 2 0 2 0 5

S i n c e r e l y y o u r s , A

Contrsccing Of-. Carc inoge i?es i s C o n t r a c t s S e c t i o n Research C o n t r a < r s Eranch N a t i o n a l Cancer I n s t i t u t e

L 1ci.r

E n c l o s u r e

Page 7: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

0 0 DEPARTMENT OF HEALTH AND HU"IAN

PUBLIC H E b - T H SERVICE

\ A T i O * . i A L INS' '-u'ES OF H E A L ' H

B E T H E D 4 V A D f L A ' u D 2 0 0 ' 4

March 5 , 1981

Our Reference: Contract No. YO1-CP-90203 Modification No. 2

Department of Energy Oak Ridge Operat ions P.O. Box E Oak Ridge, Tennessee 37830 Attention: William R. Bibb, Director

Research Division

Gentlemen :

Enclosed are three copies of the referenced proposed agreement. Please sign and return two copies to:

Rodolfo M. Reyes Contract Specialist Carcinogenesis Contracts Section, RCB National Institutes of Health Blair Building, Room 2A07 Bethesda, Maryland 29205

This modification has already been signed (copy enclosed), however, it is not binding because we do not have an original signature. The modification should be back-dated to March 1, 1981 to comply with the effective date of this increment.

When this agreement is accepted by the Government, an executed copy of this agreement will be returned to you.

Sincerely,

,

Vernon Raine Contracting Officer

4 Enclosures

Page 8: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

Depa r t n e n t o f Ener gV Oak Ridge Operat i o n s

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rd / I P I U ~ I ? . s w r .

odr I P.O. Box E oak Ridge, Tennessee 37830 J I 9 MODIFICATION CCNTPACTIORDER OF NO ___ YO?-CP-90203

4-1-79 D A T E D __ I ‘ r r l i h x & I I I

The Changer L I (om 10 b.ocb I 2 ore modt Io Iht obove n v m k r e d cont rod lordcr !

The p u r p o s e of t h i s m o d i f i c a t i o n i s t o a l l o t a d d i t i o n a l funds t o t h e s u b j e c t zgreement i n t h e amount of $129,279 i n a c c o r d a n c e t o t h e ” L i m i t a t i o n of Funds“ c l a u s e , a n d t o I r e d u c e t h e t o t a l amount o f t h e a g r e e m e n t bv $26,301. I

. , . The agrt‘excn: Ls . e r c3 ; l-i i , inrcd as r e f l e c t e d i n ::IC i t t , l c h e d 1 1 ~ ~ ~ ~ , 1 : ! , ~ O ~ I . , ; _ .

The a g r e e m e n t amount i s h e r e b y changed from S417,358 t o $391,057.

The e x p i i d t i u n d a ~ e r t m i i n s unchanged a t FeSi-uar;. 23, 1983.

30- 101

Page 9: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

., C O N T R A C T NO.

4 .

. YO1-CP-90203

NOW THEREFORE, THE PARTIES DO SIUTUALLY AGREE TO AXEND T H E AC,REE!lENT AS F3LLOWS:

P A G E 2 OF 2 P A G E S -- SPECIAL PROVISIONS

ARTICLE IV - COXSIDERATIOS - is he reby amended a s fo l loy r s :

A. For pe r fo rmance of t h i s Agreement, t h e Sponsor a g r e e s t o r e imburse t h e Agency i n t h e e s t i m a t e d amount of $391,057 i n s t e a d o f $417,358.

B. To ta l f u n d s c u r r e n t l y a v a i l a b l e f o r payment and a l l o t t e d t o t h i s agreement are $391,057. F u r t h e r a l l o c a t i o n of f u n d s h e r e u n d e r will b e accomplished a t t h e o p t i o n o f t h e Sponsor , depending upon t h e p r o g r e s s and r e s u l t s of tlie work and s e r v i c e s per formed u n d e r ARTICLE I l u r i r i b t h e peLidd of c h i s Agreement.

C. It i s e s t i i n a t e d t h a t t h e amount of funds c u r r e n t l y a l l o t t e d uader B. above, w i l l c o v e r t h e per formance from March 1, 1981 th rough February 28, 1932. The C o n t r a c t i n g O f f i c e r may a l l o t a d d i t i o n a l f u n d s t o t h e Agreement wi thou t t h e concur rencg of t h e Agency.

H E W - 5 5 5

Page 10: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

MAR 2 7 1981

Mr. Ralolfo W. WycS Cantract Spectallst brcf msrls Contrrctr SeCtton, RCZ! COationa "p Inritltu$rr of Health Blair Bullding, rtaaa 2AD7

bear Hr. R e y w

- Betherda Haryhfd PO205

* OF& PROJECT, WA REPAIR 1% CMClNOCENfSIS' (IKTERAG€MCY ACP.EE-1ENT DOE NO. ~ - 1 0 1 i . n ~ CICI NC;. Y O ~ - C P - ~ O Z ~ ~ )

!-loafficatlon Ho, 2 to the subject agrefmnt i s acceptable, and two copim signed on behrlf of the Department of ERIW w e enclosed. -

Upon receipt of e f i t l y executed copy o f the agreement, wc wlll authorize the Oak RidSe Natfonal L a k r a t o r y t o conduct the project, as described I n the agremente throusii fetruary 29, 1922, 4 t h addlttonal fundtng of 1129,;75.

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Page 11: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

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' 0 D E P A R T V E \ T OF H E A L T H EDUCATIOX A N D WELFARE

PUBLIC H E A L T H 5 t R i i I C t

Reference: Interagency Agreement No. YO1 -CP-90203 Modification No. 1

Department of Energy Oak Ridge Operations P.O. Box E Oak Ridge, Tennessee 37830

Attention: Mr. William R. Bibb Director, Research Division

Gentlemen:

The attached modification referenced above was signed and returned to our o f f ice . required on this modification and we are therefore returning your copy to you for re tent ion.

The Contractor's signature was not

Si ncerel y ,

\Contract Special is t Carcinogenesis Contracts Section Research Contracts Branch National Cancer Ins t i t u t e

i

Page 12: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

I

i ; T h e p u r p G s e o f t h i s m o d i f i c a t i o n i s t o a l l o t a d d i t i o n a l funds t o t h i s a g r e e m e n t .

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Page 13: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

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P A G E 2 O F 2 P A C E S -- S P E C I A L PROVISIONS 0 *i..S- NO -

.Y 01 -c3-90203 1

: r 8 1 s mog'f icat ion =1 i s b?ing e n t e r e d i n t c betweec tne G?jcrz--ient of Ecsrgy . h b : Ricc,e Sa t iona l L a b w a t o r y and the Nati3r.al I n s t i t u t e s c f Kea1 t h , i : a t i o r , ' Lancer i n s t i t u t e (NCI).

Nw t h e r e f o r e , the p a r t i e s do m u t u a l l y a g r e e t o ayend the a g r e m e n t as f o l l c ; . s :

ARTICLE IV - CONSIDERATION - Paragraphs B and C a r e amended t o read a s fOllG;.S:

B . Total funds c u r r e n t l y a v a i l a b l e f o r reimburser,ent and a l l o t t e d t o t h i s Agreement i s $261,778. Further a l l o c a t i o n of funds hereunder w i l l be accomplished a t the o p t i o n of the Sponsor, depending upon the p r o g r e s s and r e s u l t s of t h e work and s e r v i c e s performed under A r t i c l e I d u r i n g the per iod of t h i s Agreement.

C . I t i s es t imated t h a t the amount of funds c u r r e n t l y a l l o t t e d ucder 6. above w i l l cover the performance through February 28, 1981. The Contract ing O f f i c e r may a l l o t a d d i t i o n a l funds t o the Agreement wi thout the concurrence of the Agency.

Page 14: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

Department of Energy Oak Ridqe Operations P O . B O ~ E . Oak Ridge.Tennessee 37830

Union Carbide Corporation Nuclear Division A l l N : Dr. H e m n Postma, Director

Post Of f ice Box X Uak Ridge, Tennessee 37830

Oak Ridge National Laboratory

Gent 1 men:

ORNL PRUJECT, "DNA REPAIR MECHANISMS I N CARCINOGENESIS" (INTERAGENCY AGREEMENT DUE NU. 40-1011-79, NCI YO1-CP-90203)

The Department of Energy and the National Cancer I n s t i t u t e (NCI) have executed Modification No. 1 t o the subject agreement author- i z ing additional avai lable funds of $143,643.

You are authorized t o continue the pro ject fo r N C I i n accordance wi th the enclosed m d i f i c a t i o n . The $143,643 authorized by t h i s l e t t e r w i l l be included in the UCCND contract f o r reimbursable work under Ac t i v i t y 40 04 04.

Please conf inn your w i l l ingness to conduct the requested work f o r N C I as incidental o r related t o the approved DUE progran a t ClRNL pursuant to A r t i c l e 111, Paragraph (c> o f Contract No. W-7405-Eng-26 by signing and dating a copy o f t h i s l e t t e r and returning i t to us.

S i ncerel y,

* . L

Joseph A. Lenhard, Assistant Manager ER- 13: WRB

Enclosure: Modification Accepted ?

for Energy Research and Devel opnen t

/- p /

cc w/enc l : R. F . Hibbs, UCCND I - /e,

J. K. Denton, UCCND , I G. W. Horde, UCCND Date -5/d I 2- 71 - ,

W. T. Carter, UCCND

W. P. Snyder, CC-10, ORa M. M. Dare, PB-10, URO (2 )

H. S. aster, AD-43, URU $0, i r ! ! e

?

Page 15: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

Department of Energy Oak Ridge Operations PO. Box E Oak Ridge, Tennessee 37830

Mr . Daniel J. Longen Contracting Clfficer Carcinogenesis Contracts Section Research Contracts Branch National Cancer I n s t i t u t e Bethesda, Maryland 20205

Dear H r . Longen:

URNL PWJECT, "DNA REPAIR MECHANISMS I N CARCINOGENESIS" (INTERAGENCY AGREEMENT WE NU. 40-1011-79, N C I YO1-CP-90203)

Modif icat ion No. 1 to the subject agreement i s acceptable, and the or ig ina l copy signed on behalf of the Department o f Energy i s enclosed.

We have authorized the Oak Ridge National Laboratory to continue the project, as described i n the agreement, w i th additional funding of $143,643,

Sincerely,

ER- 13: WRB

Enclosure: Modification

cc w/o encl: J. E. Carr, ClRNL W. P. Snyder, CC-10, CIRCI

rrJ&&&& W i l l i a m R. Bibb, Director Research D i v i s ion

Page 16: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

'1 . February 25 , 1980 . . . .

Our R e f e r e n c e : I n t e r a g c n c y Agreement Yo. Yo1 CP 90203 Modi f ica t ion No. 1

Department o f Energy Oak Ridge Operations P.O. Box E Oak Ridge, Tennessee 37830

A t t e n t i o n : M r . W i l l i a m R. Bibb D i r e c t o r , Research D i v i s i on

L a d i e s and c e n t l e m e n :

We a re e n c l o s i n g a n e x e c u t e d copy o f t h e s u b j e c t agreement € o r your r e t e n t i o n : c i l l t h i s off i c e (301-427-8771) o r w r i t e t o :

If you have a n y q u e s t i o n s r e g a r d i n g i t s a d m i n i s t r a t i o n

Rodolfo M. Reyes C o n t r a c t S p e c i a l i s t Research C o n t r a c t s Branch N a t i o n a l Cancer I n s t i t u t e N a t i o n a l I n s t i t u t e s of H e a l t h Blair B u i l d i n g , Room B-24 Cethesda , ?fargland 2C205

S i n c e r e l y y o u r s ,

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. -

C o n t r a c t i n g o f f i c e r C a r c i n c g e n c s is. C o n t r a c t s S e c t ion Research C o n t r a c t s Branch N a t i o n a l Cancer I n s t i t u t e

E n c l o s u r e

L

.. -.

,

'.

Page 17: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

I rlatio!:al Cancer I n s t i t u t e , N ' I H Carc inogenes is Contracts Sec t ion , RC3 B l a i r Bu i ld ing , RCGZ E - 2 4 ' Ty;;e o f Agreement: Cosi-qeinbursement Bethesda , Maryland 20205 I s egm e n t : ;qo 1 ec ,, 1 a r ca r c i nog e nes i s I

7 CONTRACTOR C9D€ F. iCILIT>' CODE i 3 i NAN ANO ADDRESS AYENCMENT OF

50LlClTATIOti NO

1 DATED (Set block 9)

Department of Energy Oak Ridge Operat ions

Oak Ridge, Tennessee 37830

I f S l r n t . C l r ) . roumty. iiote. P. 0. B O X E ~ HODWA:ION OF -cP-90203

CONTRACT/ORDER NO

DATED 4-1 -79 (Str b l d 1 I )

1

I i ; The agreement amodnt i s unchanged a t $417,358. i 1 The e x p i r a t i o n da te i s unchanged a t February 28, 1982.

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Page 18: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

--- - , - - R a C T N O

5 P E C i A L P R O Y l S l O N S

Now therefore, the parties do m u t u a l l y agree t o amend the agrement as f c 1 1 G a :

f - , !I. P A S E 2 OF 2 P A C E S 5 * ' . . - -

A R T I C L E IV - CONSIDERATION - Paragraphs B and C are amended t o read as follows:

6. Total funds currently available for reimbursement and allotted t o this Agreement i s $261,778. Further allocation o f funds hereunder will be accomplished a t the option of the Sponsor, depending upon the progress and resul ts o f the work and services performed under Article I during the period of t h i s Agreement.

C. I t i s estimated tha t the amount of funds currently a l lo t ted ucder B . above w i l l cover the performance t h r o u g h February 28, 1981. The Contracting Officer may a l l o t additional funds to the Agreement without the concurrence of the Agency.

: ;

Page 19: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

f € 8 2 1 1980

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DEPARTMENT O F HEALTH. EDUCATION. A N D WELFARE

P U B L I C H E A L T H SERVICE

I A T l O h A L I V 5 T I T U T E S OF H E A L T H

B E ' H E . P A U A R Y C A Y D 2011'4

Our R e f e r e n c e : C o n t r a c t No. Yo1-CP-90203 T i t l e : DNA R e p a i r Mechanisms i n C a r c i n o g e n e s i s

Department of Energy Oak Ridge O p e r a t i o n s P . 0. Box E Oak Ridge , Tennessee 37830

A t t e n t i o n : M r . W i l l i a m R. Bibb D i r e c t o r Resea rch D i v i s i o n

Gent 1 emen :

I n r e f e r e n c e t o t h e s u b j e c t c o n t r a c t , a f u n d i n g inc remen t i s due

March 1, 1980 f o r t h e p e r i o d t h r o u g h F e b r u a r y 28, 1981 . P l e a s e

inform t h i s o f f i c e i n w r i t i n g , by F e b r u a r y 20, 1980 whe the r t h e r e w i l l

b e any unexpended f u n d s f o r t h e p e r i o d end ing F e b r u a r y 28, 1980.

Th i s i n f o r m a t i o n w i l l e x p e d i t e t h e p r o c e s s of t h e a c t i o n t o add t h e

n e x t f u n d i n g i n c r e m e n t .

S i n c e r e l y , f

C o n t r a c t i n g O f f i c e r C a r c i n o g e n e s i s C o n t r a c t s S e c t i o n Resea rch C o n t r a c t Branch N a t i o n a l Cancer I n s t i t u t e

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Department of Energy Oak Ridge Operations P.O. Box E Oak Ridge, Tennessee 37830

Attention: Mr. William R . Bibb, Director Research Division .

Subject : Interagency Agreement No. ~01- Cp-90203

Gentlemen:

We are enclosing an executed copy of the referenced agreement for your retention. If you have any questions regarding this document, call this office (301-427-8771) or write t o :

Cont rac t Spec ia 1 is t Carcinogenesis Contracts Section, RCE, NCI National Institutes of Health Blair Building, Room 8-20 Bethesda , Maryland ~e~M20205

Sincerely yours,

Enc losute

Joseph Federl i ne Contracting Officer

NIH-FL-2 Rev. 4-76

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. . . . .

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0 . I

. _.

c - .-

. -

2 . A n n u a l / F i n a l l j p s o r t

Annua 1 .., 3 i

1 I

k'i n a l L I

A X T L C L E V I I'iioJECZ CFFICEK

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P r i n c

TI'i'LS

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i o 1 CP 90203

h . b .

L . 0 . c . r- . G . h . L . J . K. L. ?I .

u i r e c t LaDor r'r i n g e Y Q n - L i t s 'I r a v e 1 p i a t e r i a l s / S u p p l i + s H i s t o l o g y A n i a a l Care h a i n t P n a n c e / Cra t t S u p p o r t Lomputer S e r v i c e l e c n n i c a l Infor inat ion

D i v i s i o n A a m i n i s t r a t i o n U t i l i t i e s b c r A

assware nashin;:

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.

Unf on Ca rbl de Corpora t Ion Me1 ear D1 VI rlon A n R : Or. H e w n Postm, Director

Post Offlcs %ox x I .

Oak Rldge, Tennessee 37830

Gent 1 emen:

Oak RIdga WIt loMl laboratory -

> - c*

HCI P W E C T "DNA R E P A I R RECHANISr! 111 CAUCfNOGEKSIS'. (IWTEIMGENCY ACPEPEYT DOE NO. a ~ o i i - t ~ , NCI NO. yo1 CP 90203)

T?IC 9epartment of Energy and Natlonal Cancer Inrtltute haw a x a u t d the subject agrement as desertbed fn .th.e Dropooal tranmlttd by p u r letter of F&rury 23, 1979 and che enclosed agreement. ' lb period of perfomnce Will be through February 28, 1982. . $1B,135 Is prwlded for thc period of April 1, 1979 through February 28, 1980.

You a r e authorlzed to conduct the project for NCI In accordrnca wi th thc OWL proposal and enclosed sgreenent. the $118.135 ruthorired by t h f r letter wlll be Included tn the U C U f D contract for reiaborrable work un+r q c t f v f t y 49 C4 nt. Thfs work 1s of proaramatfc lnterest t o rpF and shal l be conducted on M actual cost basls, dcprcclatlon and ME added factor waived.

Current ttrndlnq ob

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z ... * *.

4

' I n i o n C a rh I ri e Cc mo f a t 1 on -?-

Please c o n f i m p u r wlllfnqncss t o conduct ?be requested work for K I a s i n c i d e n t a l or r e l a t e d t o the approved DOE prwran a t ORHL plirsuant to A r t i c l e 111, Paracjraph ( c ) of Contract rto. w-7435-eng-26 by signing rnd dat ing a copy of thls letter and returning I t t o us.

Slncercly, 'ORIGINAL SIGNED BY B L C U b EuJ

- /

Agreement

cc w/cncl : 8. F. Hibbs, UCCND c . u. Horde, ucm9 C d J . K. Denton, UCCND 'R. 1. Carter, UCCRO c. w. H i l l H. S. Ortar

, T u W. M i t e (2)

Joseph A. Lanhard, Assistant Wager ~ for Energy Research and Devalopent

c

ACCEPTED B Y :

DATE:

79 ' . . .. .

OFFICIAL FllE ' COW

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APR 2 5 1979

Pr. Joseph Federl ine Contract S x c i a l i s t Carcinogenesls Contracts Section, RCI! Yatfona? I n s t l tutes a i t'ealt)! Nalr Cuilding, Foon 9-24 fletbcsda. Vary land 202P5

Dear Vr. Federl ine:

The Interagent:! asreecent t ransmitted by your letter of Aprll 5 , 1973 i! acceptable, and twc conies signed an hehalf o f the Departnept of Enerqy arc enclosed. The asrcemnt provides ?IC1 funding the amunt o f t118,13! t o supwrt the F Y ' s ?ak Rf4ae Rational Laboratory subject prc.ject,

Please r e t u r n a CODY o f the enclosed acjreenent t o t h f s off ice when I t has ken slgned on behalf o f the flatfanti1 Cancer Institute. Upon receict of the fully c x e c u t d agrement, we wlll authorlre ORIlL to conCuct the ?ro?ect i n accordance wi th the OWL Drowsal t r a n s d t t c d to 'XI 3y 'Ir. J O S P P ~ A. L e n h a e ' s l e t t e r February 23, 1578, and as md1fip-I by the enclosed agreewnt.

5 1 ncerel y ,

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. . . _ - A _ -

i ,[. -,

Department of Energy Oak Ridge Operations P.O. Box E Oak Ridge, Tennessee 37830

t j t t e n t l a n : K . M . Haythorn, Director

s l J b J eC t '

Energy Programs and Support Division I n t c : , l - . no . r ' i , rcel~snt Nc. YO1 CP 90203 ' I n i l l ] ' 1 > . L . 1

Joseph Federline Contracting Officer, CCS, RCB, N C I

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..

Eepar tmen t o f Energy 1000 Independence i\.venuc, ::. la l .

- - - " L - c b " L t I C

Oak, R i d % € , Tennessee i t e m a n d c o n d i t i o n s of ARTICLE I /

' x ' a t i c n a l Cancer I n s t i t u t e C

DEPARTMENT OF ENERGY

I I

Deputy Assistmt F::zna>?r c for I

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7 0 u

3 . S?,LLAL PKCi'JLSIOSS

Ari l ICLE. 1

A i l i - I C L E Ii

ARTICLL I11

AKTICLT; IV

AXTICLE VI1

A K i ; C L E V L L I

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. .

. . 0

&Oh', T H E R E F O R E , t h p p a r t i p s d o z g r o + a s follows:

1 .

2 . P K O J E C T E : I n h i b i t i o n o f G & A R e p a i r

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..

a . Th* i n t : i b i t i o n o t p o s t r + p ; i r a t i o n r e p a i r J u r t o v i r a l infert!?n t-ouiCi 5. d u e t o e i t h P r o f two d i s t i n c t c a u s a s . r o n s e q u * n c * o f t h * i n s o r t i o n of t h e v i r a l CNA ( p r o v i r u s 1 i n t o t n s ,:i.st g ~ ; i ~ x e uti i ~ t i i n a n a s y - t u ; i s p @ c i f i p 3 iila1in-r d i s r u p t s n o r x a l p o s r r ~ p : i - c a t i o n r + p a i r . S ~ c o n d . i t c o u l d D p a c-ons*qusnc@ o f :h+ i x t p r z r i i o n Uf a v i r a l gpii* p r o d u c t o r p r o d u c t s ( p e r h a p s t n s e n t i r e v i r i o n ) w i t h Z i t h G r h o s t c e l l UXA or t n e r d p a i r a p p a r a t u s i t s a l f . A d i s t i n c t i o n be :u=pn ;:ipse

a l t ~ r n a t i v s h y p o t n p s e s b y u s i n g t P n p G r a t u r e c o n d i t i o n l e t h a l {TS, a u t a n c s cf K L V w i l l 5- m a d e .

F i r s t , i t c o u l d sir,;p;;: ;a a

13. LEVEL OF EFFOLT -- --

I . Zn a c r o s p l i s h i n ~ t h e w o r k se t f o r t h i n AkTICL5 I h e r e o f . the. Cent-ac:or 3h11 i p r o v i d e 6 . 0 d i r e c t l a b o r :n3n--ypars d u r i n g t n s p e r i o d se t f o r : h i n .A.KTILLE 111. I t i s @ s t i t n a t o d t ha t t h e m a n - y a a r s a r p c o n s t i t u t e d a s f o l lows:

Page 38: BEST COPY · Our Reference: Interdgency Agreement No. YO1 -CP-90203 UepartmeriL of Energy Oak Kid ye Uperat i ons 9.0. 8ox E Oak Ridge, Tennessee 37830 Attention: Wi 11 i am R. Bibb

Principal : n v s s t 1 g a t o r .21 .23 .?8

1 .63 1.80 1 .30 T o t 2 1 1.84 2 . 0 8 2 .08

-- 8GsParc-h S c p p o r t ( 2 )

A R T I C L E 111 P E R I O D OF P L R F O P i A N C E

The period of p p r i o r m a n r e of t n e k g r p p r . e n t s h a l l b e f rom A p r i l I , 1 9 7 9 :n rough Febrcrary 23, 1982.

I O / 1 / 79 r r o g r a 2 ;i a na r lO/l/tO (;n prn i c a I /;lo i Q C u a r I O i l / S I Carcinogenpsis Trogram

C i J C B , K L I L a n d o v e r 51 d g . lioor.1 sc-2s 2 9 1 Q Noodmonr A v o . b a t h p s d a , N a r y l a n d 20209

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Annual L(

31,

1

E'iiial i

A R T I C L E VI PRQJZCT CFFICER

L)r . Da'I i a Long f. 1 1 ow C h i e f , ? l o l ~ c u l a r Cark-inoSPnesis S s c t i o n , C P L ~ N a t i o n a l Cancer I n s t i t u t e Landow B l d g . , Koom 8C-29 791 0 L'oodmont AVQI-~U~ B e t h e s d a , h a r y l and 20205

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. .

For g u i d a n c e f r o 3 t h e P r o j + c t 0 t f i r . j r t o t h a C o n t : - a r t \ > r io 00 v a l i d , i t m u s r : ( I ) BQ c o n s i s t e n t w i t h tii+ dPsL-r ipt ion o f r r o r k SJY t o r : h i n t n i i c o n t r a c t ; ( 2 ) n o t c o n s t i t u t p n e w assign::pnt o f work o r c n a n g ~ ; o t h s + x p r d s s * d t”r-r.s, c o n d i t i o n s , o r s p e c i f i c a t i o n s i n c o r p o r a t e d i n t o t h i s c o n t r a c t ; ( 3 ) not c o n s t i t u : p a b a s i s f o r an e x t e n s i o n t o t n a poriod o f p p r f o r n a n c ? o r co i l t r ; i c t d * l i v + r y sch+dulp; ( 4 ) n o t c o n s t i t u t p a b a s i s fsr aa;; i n c r p a s s i n t h e c o n t r a c t c o s t .

i&i E -_L

T i l i S

C o n t r a c t i n g O i f i c a r Care i nogenpsi s Cont r a c t s S r c t i on Kpsparch C o n t r a c t s Branch iu’at iona l CancOr I n s : i tu:+ G l a r i b u i l d i n g , ZooiX E-16 S 3 G O Col p sv i 1 1 Road Silv0.r S p r i n g , Eiaryland 20235

.- . . . . . . . . ..

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8 0 U

A . n . c . u. L. E . I;.

ti. 1. J . K . L . .il .

D i r e c t LaDor Fringe bPnPfits i r d v ~ l riater iais/auppl I P S

HIS t 0 1 o j y Animal LarP kl a int na nc e / C r a t t 5 J ppo r t Lomputer S e r v i c e l ~ c n n i c a l Lniorinat i n n Glassware nasning Uivlsion Administration L t l 1 It 1 0 s L c x A