becoming a pi – how do i get from here to there? philip norris bsri

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Becoming a PI – How do I get from here to there? Philip Norris Philip Norris BSRI

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Page 1: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Becoming a PI –How do I get from here to there?

Philip NorrisPhilip Norris

BSRI

Page 2: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Success rates for R01 grants

0%

10%

20%

30%

40%

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

NIAID R01 success rates

New R01 (all NIH)

http://report.nih.gov/success_rates/index.aspx

Page 3: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Funding by submission #

0% 10% 20% 30% 40% 50%

SecondResubmission (A2)

First Resubmission(A1)

First (Original)Submission

http://report.nih.gov/success_rates/index.aspx

Page 4: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Average Age of New Investigators at Initial R01 Equivalent award

34

36

38

40

42

44

19

70

19

71

19

72

19

73

19

74

19

75

19

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19

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19

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19

98

19

99

20

00

20

01

20

02

20

03

20

04

MDMD-PhD

PhD

http://grants.nih.gov/grants/new_investigators/Average_age_initial_R01.xls

Page 5: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Case study of a PI start-up

Page 6: Becoming a PI – How do I get from here to there? Philip Norris BSRI

PI support

$-

$50,000

$100,000

$150,000

$200,000

$250,000

2004 2005 2006

PI direct

PI indirect

PI total

Page 7: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Grant applications

0

1

2

3

4

5

6

2004 2005 2006

PI

Total

Page 8: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Publications during start-up

0

1

2

3

4

5

6

2004 2005 2006

First/last author

Total

Page 9: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Collaboration can save lives

Page 10: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Overall support increasing in spite of decreased PI awards

$-

$200,000

$400,000

$600,000

$800,000

2004 2005 2006

Overall direct

Overall indirect

Overall total

$-

$50,000

$100,000

$150,000

$200,000

$250,000

2004 2005 2006

PI direct

PI indirect

PI total

PI funding Total funding

Page 11: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Keep trying!

Page 12: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Grant applications

0

4

8

12

2004 2005 2006 2007 2008 2009

PI

Total

Page 13: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Extramural supportPI funding

$-

$400,000

$800,000

$1,200,000

$1,600,000

$2,000,000

2004

2005

2006

2007

2008

2009

2010

pro

jecte

d

PI direct

PI indirect

PI total

Page 14: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Extramural supportTotal

$-

$400,000

$800,000

$1,200,000

$1,600,000

$2,000,000

2004

2005

2006

2007

2008

2009

2010

pro

jecte

d

Overall direct

Overall indirect

Overall total

Page 15: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Publications

0

4

8

12

2004 2005 2006 2007 2008 2009 2010

First/last author

Total

Page 16: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Don’t spread yourself too thin

Page 17: Becoming a PI – How do I get from here to there? Philip Norris BSRI

Diverse projects and funding streams

Funding sources HIVHIV -- CHAVI, CFAR,

WIHS WNV – NHLBI / NIAID MicrochimerismMicrochimerism – NHLBI TRALI – REDS /

SCCOR Pathogen reduction –

DOD / Industry Transfusion immunology

–NHLBI / DOD

HIV Immunology Immune correlates of protection Early HIV/SIV immunity

WNV Immunology CD4+ T cell epitope definition Treg quantification

Transfusion Immunology Defining immunology of

microchimerism Immune responses to transfusion TRALI / HLA antibody quantification Pathogen reduction effects on WBCs