beam directed radiotherapy - methods and principles
TRANSCRIPT
![Page 1: Beam Directed Radiotherapy - methods and principles](https://reader036.vdocuments.site/reader036/viewer/2022081415/555722a1d8b42a067f8b4b75/html5/thumbnails/1.jpg)
Beam Directed Radiothe
rapy – Principle
s and practice
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Definition
Exact Calculations Beam Directing devices
Advance Planning
Beam directed radiotherapyBeam directed radiotherapy
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Need for Beam directionHomogenousHomogenous Tumor Dose LowLow normal tissue dose
Best therapeutic ratio
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
StepsPositioning
Immobilization
Localization
Field SelectionDose distribution
Calculations
Verification
Execution
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Positioning• Patient positioning is the most vital
and often the most NEGLECTEDNEGLECTED part of beam direction:
• Good patient position is ALWAYS:– Stable.– Comfortable.– Minimizes movements.– Reproducible.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Examples
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Standard Positions
• MC used body position.• Also most comfortable.• Best and quickest for
setup.• Minimizes errors due to
miscommunication.
• Best for treating posterior structures like spine
• In some obese patients setup improved as the back is flat and less mobile.
Supine
Prone
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Positioning aids• Help to maintain patients in non
standard positions.• These positions necessary to
maximize therapeutic ratio.• Accessories allow manipulation of
the non rigid human body to allow a comfortable, reproducible and stable position.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Positioning aids…
Pituitary Board
Prone Support
3 way support
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Breast Boards• Disadvantages:
– Possibility of skin reactions in the infra mammary folds
– Access to CT scanners hampered
• Solutions:– Thermoplastic
brassieres.– Breast rings.– Prone treatment
support.
• Allow comfortable arm up support ► brings arms out of the way of lateral beams.
• Positions patient so that the breast / sternum is horizontal ► avoiding angulation of the collimator.
• Pulls breast down into a better position by the pull of gravity.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Breast boards…
Modern Breast Board
Indexed Arm supports
Indexed wrist support
Head rest
Carbon fiber tilt board
Wedge to prevent sliding
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Arm Support
• Also known as the T bar.
• Allows the arm to be positioned laterally when treating the thorax using lateral beams.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Belly boards & leg immobilizer`
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Mould making
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Mould making : Contd..
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Mould making : Contd..
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Thermoplastics• Thermoplastics are
long polymers with few cross links.
• They also possess a “plastic memory” - tendency to revert to normal flat shape when reheated
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Thermoplastics : Principle
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Foam systems• Made of polyurethane• Advantages:
– Ability to cut treatment portals into foam.
– Mark treatment fields on the foam.
– Rigid and holds shape.
• Disadvantages:– Chance of spillage– Environmental hazard
during disposal
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Vacuum bags
• Consist of polystyrene beads that are locked in position with vacuum.
• Can be reused.• However like former immobilization not perfect.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Bite Blocks• A simple yet elegant
design to immobilize the head.
• A dental impression mouthpiece used.
• The impression is attached to the base plate and is indexed.
• Head position recorded with 3 numbers.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
SRS devices• Sterotactic frames.• Gill Thomas
Cosman System.• TALON® Systems –
NOMOS corp.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Localization• The target volume and critical normal
tissues are delineated with respect with respect toto patient’s external surface contour.
• What to localize?– Tumor– Organ
• Methods?– Clinical examination– Imaging
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Why Localize?• Irradiate the tumor and spare the
normal tissue.• Allow calculations and beam
balancing.• Define radiation portals.• Use the beam directing devices.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Clinical localization• Advantages:
– Available everywhere. – Cheapest and quickest(?).– Needs little additional equipment.
• Disadvantages:– Error prone in the wrong hands.– Accessible areas required.– Volumetric data not easily obtained.
• Clinical localization is mandatory despite advanced imaging – need to know what to image!
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Imaging Localization• Imaging:
– X-rays:• Plain • Contrast Studies
– CT scans– MRI scans – USG scans– PET scan– Fusion imaging
• Type of study selected depends on:– Precision desired.– Cost considerations– Time considerations– Labour
considerations
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
X rays• The most common and
cheapest modality available.
• However 2-D data acquired only.
• Orthogonal films can be used with appropriate contrast enhancement for localization in 3 dimensions.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Estimation of depth• From data gained by localization
studies:– CT / MRI – Accurate data– Lateral height method– Tube shift method
• Depth estimation necessary for:– Calculations– Selection of beam energy
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Lateral height method
d
d
H1 + H2
2d =
H1H2
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Tube shift method• Image shift and tube shift are
interrelated WHEN the tube to target distance remains constant.
• Goal: To obtain a graph of different object heights against the tube shift.
• Serial measurements of image shift measured (for same tube to film distance) while varying the height of the markers above the table.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Tube shift principles
Marker
d2
y
f
S
Tumor
x1
x2
d1
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Calculation
d1
f
yyd2
x1
x2
x1
S=
d1
f – d1
S
x2
S=
d2
f – d2
yy = d2 – d1
= fx2 + S
x2 -x1 + S
x1
TumorMarker
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
CT scans• Provides electron density
data which can be directly used by the TPS.
• Volumetric reconstruction possible.
• Good image resolution - better where bony anatomy is to be evaluated.
• The image is a gray scale representation of the CT numbers – related to the attenuation coefficients.
• Hounsfield units = (μtissue – μwater) x 1000/ (μwater)
253 265 235
125 125 112
56 450 156
135 158 247
269 300 65
36 123 598
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
CT scan perquisites• Flat table top • Large diameter scan aperture
(≥ 70 cm).• Positioning, leveling and
immobilization done in the treatment position.
• Adequate internal contrast – external landmarks to be delineated too.
• Preferably images to be transferred electronically to preserve electron density data.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
MRI scans• Advantages:
– Imaging in multiple planes without formatting.– Greater tissue contrast – essential for proper
target delineation in brain and head and neck– No ionizing radiation involved.
• Disadvantages:– Lower spatial resolution– Longer scan times– Inability to image calcification or bones.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Fusion Imaging• Includes PET – CT
imaging and Fusion MRI.
• Allows “biological modulation” of radiation therapy.
• Technology still in it’s infancy – (?) The future of radiotherapy.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Patient Contouring• Contour is the representation of
external body outline.• Methods:
– Plaster of Paris– Lead wire– Thermoplastic contouring material– Flurographic method– CT/MRI
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Contour Plotter
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Radiation Field
• Types:– Geometrical: Area DEFINED by the light beam at any
given depth as projected from the point of origin of the beam.
– Physical: Area encompassed by the 50% isodose curve at the isocenter. In LINACs often defined at the 80% isodose.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Single Field• Criteria for
acceptability:1. Dose distribution to
be uniform (±5%)2. Maximum dose to
tissues in beam ≤ 110%.
3. Critical structures don’t receive dose exceeding their normal tolerance.
• Situations used:– Skin tumors– CSI– Supraclavicular
region– Palliative treatments
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
2 Field techniques• Can be :
– Parallel opposed– Angled
• Perpendicular• Oblique
– Wedged pair
• Advantages:– Simplicity– Reproducibility– Less chance of
geometrical miss– Homogenous dose
• Dose homogeneity depends on:– Patient thickness– Beam energy– Beam “flatness”
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Multiple fields• Used to obtain a “conformal” dose
distribution in the modern radiotherapy techniques.
• Disadvantages:– Integral dose increases– Certain beam angles are prohibited due to
proximity of critical structures.– Setup accuracy better with parallel
opposed arrangement.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Dose distribution analysis• Done manually or in the TPS.• Manual distribution gives a hands on
idea of what to expect with dose distributions.
• Inefficient and time consuming.• Pros:
– Cheap– Universally available– Adequate for most clinical situations.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Calculations• Techniques:
– SSD technique (PDD method)– SAD technique– Clarkson’s technique– Computerized
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Prescription• Mandatory statements:
– Dose to be delivered.– Number of fractions– Number of fractions per week
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
SSD technique• PDD is the ratio of
the absorbed dose at any point at depth d to that at a reference depth d0.
• D0 is the position of the peak absorbed dose.
• Dmax is the peak absorbed dose at the central axis.
Total Tumor dose
Number of fieldsx
Number of #s
=T
Incident dose =
T x 100
PDD
Time =ID
Output
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
SAD Technique• Uses doses normalized at isocenter for
calculation.• In this technique the impact of setup
variations is minimized.• Dose homogeneity is better with the
SAD technique.• Setup is easier but manual planning
not possible / difficult.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
SAD calculations
Total Tumor dose
Number of fieldsx
Number of #s
=T
Incident dose =
T x 100
TMR/TARTime =
IDOutput
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
TAR vs. SSD• TAR = Tissue Air
Ratio• TAR introduced by
Jones for rotation therapy.
• Allows calculation of dose at isocenter WITHOUT correcting for varying SSDs.
• TAR is the ratio of dose at a point in the phantom to the dose in free space at the same point (Dq /D0)
Dq D0
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
TAR• TAR removes the influence of SSD as it
is a ratio of two doses at the SAME point.
• However like PDD the TAR also varies with:– Energy– Depth– Field Size– Field Shape
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Verification• Can be done using:
– Portal Films– Electronic Portal images– Cone Beam CT mounted on treatment
machines (IGRT).• Portal Films:
– Cheapest.– Legal necessity(?)– But have several disadvantages.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Port film disadvantages• Factors leading to poor image
contrast:– High beam energy (> 10 MV)– Large source size ( Cobalt)– Large patient thickness (> 20 cm)
• Slow acquisition times.• Image enhancement not possible.• Storage problems.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Electronic Portal Imaging• Video based EPIDS• Fiber optic systems• Matrix liquid ion
chambers• Solid state detectors• Amorphous Si
technology*
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Electronic Portal Imaging
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Advantages of EPIDs• Allow real time verification
of patient setup.• Acquisition times short.• Multiple images possible.• Reasonable image quality.• Software assisted image
enhancement.• Online corrections
possible.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Disadvantages of EPIDs• Cost of equipment.• Added service and software update
requirements.• Fragility of the equipment – Si matrix
deteriorates with time and exposure.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Cone Beam CT• Incorporates a
special CT scanner on the LINAC.
• Useful to obtain 3 D real time images of the patient.
• Can use kilovoltage or megavoltage CT
• Allows IGRT.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Beam direction devicesThe main beam direction devices are:
– Collimators– Front pointer / SSD indicator– Back Pointer– Pin and arc– Isocentric mounting– Lasers
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Collimators• Collimators provide beams of desired
shape and size.• Types:
– Fixed / Master collimator.– Movable / Treatment collimator.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Fixed Collimators• Protects the patient from bulk of the
radiation.• Dictates the maximum field size for
the machine.• Maximum beam size is when exposure
at periphery is 50% of that of the center.
• In megavoltage radiotherapy beam angle used is 20°.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Master Collimator : Design
20°
• In megavoltage x ray machines beam energy is maximum in forward direction.
20°
• Beam energy is equal in telecurie sources so primary collimators are spherical.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Movable Collimators• Define the required field size and
shape.• Placed below the master collimators
results in trimming of the penumbra.• Types:
– Applicators– Jaws / Movable diaphragms
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Applicators: Design
Metal Plate with hole
Lead Sheet
Box
Plastic Cap
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Applicators • Advantages:
– Indicate size and shape of beam.
– Distance maintained.– Direction shown.– Plastic ends allow
compression.– Compression allows
immobilization.– Penumbra
minimized.
• Disadvantages:– Useful for low
energy only.– Separate sizes and
shapes required.– Costly.– Shapes may change
due frequent handling.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Jaws• Handling of heavy weight
not required.• Skin sparing effect
retained.• Jaws moved mechanically
– accurately.
Jaw border lies along the line radiating from
focal spot
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Jaws: Disadvantages
Disadvantages RemedySize and shape of field remain unknown
Light beam shining through the jaws
Patient to source distance unknown
SSD indicator used.
Compression not possible
A Perspex box may be applied to the head
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Front & Back Pointers
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Front Pointer/ SSD indicator• Detachable device to measure the SSD
and align the beam axis.• Designed so that it may be swung out
of the beam path during treatment.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Back Pointer• The pointer can be moved in the sleeve.• A nipple is used to allow compression.• The arrow lies along the central ray.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Limitations• Requires skin marks – inherently
unreliable.• Back pointer is unreliable when
compression is desired.• Both front and back points must be
accessible.• Accurate localization of tumor center
is mandatory.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Pin & Arc
Pin
Arc
Bubble
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Pin & Arc: Principle
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Pin & Arc : Methodd
D
d DD
This is the isocenter
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Advantages of Pin & Arc• Allows Isocentric treatment of
– Deep tumors.– Eccentric tumors.
• Can be used with compression e.g. in treating deep seated tumors.
• Can be used for manual verification of Isocentric placement of machines
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Isocentric Mounting• First used by Flanders and Newberg of
Hammersmith Hospital for early linear accelerators.
• The axis of rotation of the three structures:– Gantry– Collimator– Couch
coincide at a point known as the Isocenter.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Principle of Isocentric mounting
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Why Isocentric Mounting?• Enhances accuracy.• Allows faster setup and is more
accurate than older non isocentrically mounted machines.
• Makes setup transfer easy from the simulator to the treatment machine.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Lasers• LASER = Light Amplification Of
stimulated Emission Of Radiation• Typically 3 pairs are provided with
the machine and intersect at the isocenter.
• Also define:– Beam Entry– Beam Exit
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
Lasers• Other uses:
– Checking the isocenter– Reproducing the setup on the simulator at
the treatment couch.
• Fallacies:– Accurate setup depends on proper
alignment of the lasers themselves– Lasers known to move frequent
adjustments needed.
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
How to setup with LASER
2. Align the fiduciary marks with the laser
system
3. Move the couch by to bring the
planned isocenter to the machine
isocenter
1. Note the coordinates of the isocenter
4. Verify the Setup
5. Treat
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Moderator: Dr F D Patel , Department of Radiotherapy, PGIMER
ConclusionTeam Work Precision
Quality Assurance
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Thank You