barts and the london school of medicine and dentistry pg 2011.pdf

Barts and The London Schoolof Medicine and DentistryPostgraduate Prospectus Entry 2011

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Contents

Why study at Barts and the London 2Medicine and Dentistry Graduate School 4Structure of the School ofMedicine and Dentistry 6Blizard Institute of Cell and Molecular Science 10

Institute of Cancer 38

Institute of Dentistry 52Institute of Health Sciences Education 76William Harvey Research Institute 86Wolfson Institute of Preventive Medicine 108

How to apply 120

Tuition fees 122Living costs and funding your study 126International students and English languagerequirements 132Campus life and accommodation 136

Useful Queen Mary websites 139

Programme index 140

Why study at Bartsand The London?

Barts and The London School of Medicine and Dentistry 3

Why study at Barts and The London?

WelcomeWelcome to Barts and TheLondon School of Medicine andDentistry. It’s a fantastic place tostudy. We’ve got world experts intheir areas of research andparticularly in cancer research, in stem cell research, incardiovascular research andcoupled with that, we’re locatedright in the heart of London.We’ve got two main campuses of the medical school, one’s inCharterhouse Square which is just round the corner from theBarbican. And the other inWhitechapel which is a thrivingarea of London with so muchhappening in it.

The School offers taught Mastersand Postgraduate Diplomaprogrammes in a wide range ofareas, including: Surgical Science;Clinical Drug Development;Forensic Medical Sciences;Healthcare Research Methods;Clinical Microbiology;Gastroenterology; Primary Care;Cancer Therapeutics; MolecularPathology and Genomics; Sportsand Exercise Medicine; ClinicalDermatology; Transcultural MentalHealthcare; Dental Public Health;Experimental Oral Pathology;Orthodontics (incorporated inMOrth Training); PaediatricDentistry; Periodontology andProsthodontics. The WilliamHarvey Research Institute is hometo the distinctive MRes degree inInflammation: Cellular andVascular Aspects.

You will find out more about theseprogrammes and others in thepages of this prospectus.

Professor Joy HinsonChair of Postgraduate Education,Barts and The London School ofMedicine and Dentistry

Medicine andDentistry GraduateSchool Professor Joy Hinson is the Deanfor Postgraduate Studies and isthe Director of the GraduateSchool. She is supported by anAssociate Dean for ResearchDegrees, Dr Paul Allen, and by an Associate Dean for TaughtCourses, Dr Martin Carrier. TheDental Institute also has anAssociate Dean for TaughtCourses, Professor Ray Croucher.

The Graduate School wasestablished in the School ofMedicine and Dentistry in order to ensure that students on bothpostgraduate taught courses andresearch degrees receive teachingof the highest academic standardand appropriate supervision andpastoral support.

Barts and The LondonSchool of Medicine andDentistry is a major centreof medical and dentalteaching and research in London. Ourpostgraduates learn from,and work alongside,renowned experts. Ifyou’re keen to build onyour existing skills andknowledge, be part of athriving postgraduatecommunity, and gain aqualification recognisedaround the world for itsquality, then this could bethe place for you.

Research is at the heart ofeverything we do at Barts and TheLondon. We have more than 250research associates or fellows, andan annual budget of approximately£30 million.

Our research activities arearranged in academic teams.Therefore, a typical researchproject might involveundergraduates on project work;intercalated or MSc students; staff supervisors who may beprofessors or consultants; doctorsundertaking postgraduate study;and non-medical basic scientistsworking for a PhD. In mostresearch centres there arepostdoctoral fellows, emeritus staffand international visitors, whichgenerates a lively and enthusiasticatmosphere for vigorous research.

The funds to support medical anddental research come from manysources. These include the HEFCEfunds administered by the College,the Charitable Foundation of StBartholomew’s and the RoyalLondon Hospitals, the Departmentof Health, industry, and bodiessuch as the Medical ResearchCouncil, the Engineering andPhysical Sciences ResearchCouncil, the Wellcome Trust andmany medical charities.

Our researchexcellenceThe 2008 Research AssessmentExercise results showed Barts andThe London School joining Oxford,Cambridge, Imperial College andUniversity College London in thetop five research-active medicaland dental schools in England.The Dental School was ranked 1st equal in the UK (withManchester).

According to rankings publishedin the Times Higher Education,Barts and The London scored inthe top five nationally in:

• The Institute of Cancer wasranked 3rd out of 14submissions in terms of 3* and4*outputs and joint 5th in theUK overall, ahead of Oxford,Imperial, King’s College Londonand University College London.

• The Blizard Institute of Cell andMolecular Science, returned inHospital-Based ClinicalSubjects, was ranked 1st equalwith Cambridge and Edinburghin terms of 3* and 4* outputs

and was joint 7th overall out of 28, ahead of Manchester,Newcastle and Southampton.

• Dentistry was ranked 1st equalwith Manchester based on 3*and 4* outputs, and 2nd overallon Grade Point Average out of14 UK dental schools. TheInstitute of Health ServicesResearch was ranked 4th overallout of 28 ahead of Oxford,University College London andKing’s College London, bothoverall and by 3* and 4*outputs.

• The William Harvey ResearchInstitute, returned in Preclinicaland Human Biological Sciences,was ranked 3rd in terms of 3*and 4* outputs, and 4th overallout of 13, ahead of King’sCollege London, Bristol andNottingham.

• The Wolfson Institute ofPreventive Medicine, returned inEpidemiology and Public Health,was 2nd out of 21 in terms of 3*and 4* outputs, and 3rd overall,ahead of Oxford, UniversityCollege London and Bristol.

Barts and The London School of Medicine and Dentistry4

Why study at Barts and The London?


Our outlookBarts and The London wasformed in 1995 following themerger of the Medical College ofSt Bartholomew’s Hospital and theLondon Hospital Medical College,both renowned traininginstitutions with long anddistinguished histories. Thisunited the strengths of theseinstitutions and the skills of thestaff that are involved in clinicalcare and internationally acclaimedresearch.

The School’s teaching hospitalsserve a large area of east Londonand the wider Thames Gateway,with a high prevalence ofdiabetes, hypertension, heartdisease, tuberculosis and otherchronic lung diseases, HIV, oraldisease, and cancer.

Barts and The London is a major referral centre offering acomprehensive range of specialityservices. The Royal LondonHospital has its own helipad anddeals with major trauma patientsflown in from around the country.The Dental School works intandem with the Dental TeachingHospital at the Royal Londonwhich has modern clinical andlaboratory facilities.

Medicine and DentistryGraduate School


Medicine and Dentistry Graduate School

The School focuses its researchactivities around six researchinstitutes. These are:

• Blizard Institute of Cell and Molecular Science

• Institute of Cancer

• Institute of Dentistry

• Institute of Health Sciences Education

• William Harvey Research Institute

• Wolfson Institute of Preventive Medicine

Each of the six Institutes has aDirector of Graduate Studies whois responsible for the researchstudents in that Institute. You willfind out more about currentresearch activity and specialistfacilities in each institute sectionfurther on in this prospectus.

Postgraduate studyopportunities The School has around 800registered postgraduate students:400 MPhil/PhD students, 100MDRes students and 300postgraduate taught coursestudents.

As a research student, you willreceive training in transferableskills in accordance with theResearch Councils skills/trainingrequirements for researchstudents. Some of this training isdelivered by the Education andStaff Development team at QueenMary and much is provided by theInstitutes.

The Graduate School organises athree-day induction programmeevery autumn term, whichincludes general research skillssuch as presentation skills,statistics, ethics, health andsafety. This is followed by awelcome party giving the newstudents an opportunity to meetother postgraduate students, theirInstitute Graduate Tutor and thestudent representatives on thePostgraduate Research student-staff committee.

Every year, usually in the summerterm, each institute hosts aPostgraduate Research day whereall research students have theopportunity to present posters andgive an oral presentation of theirresearch.

The Graduate School alsoorganises a Careers Day forresearch students with invitedspeakers from academia, thepharmaceutical industry, teaching,publishing, the Civil Service andbanking.

Postgraduate students in Bartsand The London enjoy anexcellent social life. Most socialactivities take place withinInstitutes. The Graduate Schoolalso organises social events,including a summer barbecue onthe lawn at Charterhouse Squareand a curry night in Whitechapel.These events give researchstudents and postdoctoralresearchers an importantopportunity to meet researchersfrom other Institutes across theSchool.

Taught programmes You can find detailed informationon the taught programmes listedbelow further on in thisprospectus.

Medicine• Aesthetic Surgery, PgDip(distance learning)

• Analytical Toxicology, MSc /PgDip / PgCert

• Burn Care, PgDip (distance learning)

• Cancer Therapeutics, MSc

• Clinical Dermatology, PgDip(distance learning)

• Clinical Drug Development, MSc / PgDip / PgCert

• Clinical Microbiology, MSc

• Diabetes, MSc

• Endocrinology and Diabetes,MSc / PgDip (distance learning)

• Forensic Medical Sciences, MSc / PgDip / PgCert

• Gastroenterology, MSc / PgDip

• Healthcare Research Methods,MSc / PgDip

• Inflammation: Cellular andVascular Aspects, MRes

• PGCert Advanced Mental HealthAssessmentt

• Mental Health: TransculturalMental Healthcare, MSc / PgDip

• Mental Health: PsychologicalTherapies, MSc / PgDip


Medicine and Dentistry Graduate School

• Molecular Pathology andGenomics, MSc

• Non-Invasive AestheticTechniques, PgCert (distance learning)

• Operative Gynaecology andMinimally Invasive Skills, MSc /PgDip

• Operative Orthopaedic andArthroscopic Skills, MSc / PgDip

• Primary Care, MSc / PgDip

• Public Health, MSc / PgDip

• Sport and Exercise Medicine,MSc / PgDip

• Surgical Skills and Sciences,MSc

• Translational Neuroscience,MSc / PgDip / PgCert

Dentistry• Dental Clinical Sciences, PgDip

• Dental Implantology, MClinDent

• Dental Public Health, MSc

• Dental Technology, MSc / PgDip/ GradCert

• Experimental Oral Pathology(Oral Sciences), MSc

• Implant Dentistry, MSc

• Oral Biology, MSc

• Oral Medicine, MSc

• Oral Surgery, MClinDent

• Orthodontics, MSc

• Paediatric Dentistry, MClinDent

• Periodontology, MClinDent

• Prosthodontics, MClinDent

Research degreesThere are research opportunitieswithin each of the Institutes andyou can find more information onkey research areas within eachInstitute and the researchinterests of senior staff withineach Centre in the followingsections. The School offers thefollowing research degrees withinthe various institutes:

PhD Minimum period of registration for a Doctor of Philosophy is twoyears full-time or four years part-time. Applicants must hold aminimum of an upper secondclass honours degree or overseasequivalent.

MD(Res) Minimum period of registration fora Doctor of Medicine is two yearsfull-time or three years part-time.Applicants must have full orlimited registration with theGeneral Medical Council of theUnited Kingdom.

MPhilMinimum period of registration for a Master of Philosophy is twoyears full-time or three years part-time. Applicants must hold aminimum of an upper secondclass honours degree or overseasequivalent.

CareeropportunitiesBarts and The London provides a unique postgraduate learningatmosphere for both cliniciansand basic scientists.

Our Masters level programmesprovide opportunities forexperienced clinicians to developspecific skills as well as for morejunior clinicians who wish todevelop their particular specialtiesto enhance their chosen careerpaths. Other Masters programmesprovide opportunities in areasranging from cancer therapeuticsto inflammatory disease. In manycases this allows students to gaininvaluable expertise forprofessional development, in awide variety of workplace settings,such as government laboratories,pharmaceutical companies anduniversities.

Our extensive PhD programme is widely regarded as an idealenvironment within which toacquire key research skills. Wealso put a strong emphasis onother transferable skills which areessential to equip students for asuccessful career after theirdegree.


Our PhD students are thereforesought after and highlyemployable, not only in a researchsetting (private and public sector),but also in related career pathswhere a PhD is an importantasset; notably, scientificpublishing, patenting, education,civil service, regulatory bodies,and technological and productspecialities. Our ex-students willalso be found in careers inbanking and market research andsome have established companiesof their own.

We are also involved in thetraining of clinicians who study for a PhD or an MD(Res) (oftentogether with our associated NHS

Trust Hospitals). These aredoctors who will go on tospecialist training posts, take upconsultant and clinical academicpositions, whilst continuing withclinical-based research activities.

You will find a number of graduateprofiles in this prospectusalongside the detailed programmedescriptions in each institutesection.

Further informationPlease contact:Admissions and Recruitment OfficeTel: +44 (0)20 7882 5533Fax: +44 (0)20 7882 5588email: [email protected]

A full list of the staff of the School is available from:www.smd.qmul.ac.uk

Blizard Institute of Celland Molecular Science


Institute DirectorProfessor Mike Curtisemail: [email protected]

Director of Graduate StudiesDr Paul Allen email: [email protected]

The BICMS is composed of six Centres and one Group:

• Cutaneous Research

• Diabetes

• Digestive Diseases

• Immunology and InfectiousDisease

• Neuroscience and Trauma

• Paediatrics

• Pathology Group

Key research areasCross cutting research themes ingenomic medicine, stem cells andregenerative medicine; Cutaneousresearch including epithelial stemcell biology, the genetics of skindisease and skin cancer; Diabetesincluding genetic susceptibility todiabetes, insulin biology and cellsignalling; Digestive diseasesincluding human nutrition, thegenetics of gastrointestinaldisease, neuro-gastroenterology,hepatology, gastrointestinalsurgery, colorectal cancergenetics; Immunology andInfectious Disease including T-cellbiology, mucosal immunology, TB,HIV and oral pathogens; andhaematological malignancies;Neuroscience and Traumaincluding mechanisms ofneuroprotection andneuroregeneration,

neuroimmunology, neural stemcells, neuro-oncology and traumaresearch; Paediatrics includingbone marrow failure research,Down’s syndrome research andchildhood respiratory function.

The Blizard Institute of Cell andMolecular Science is the largestInstitute of the School of Medicineand Dentistry and is based in theaward winning Blizard Building onthe Whitechapel campus. Theaims of the Institute are:

• Creation of an environment forworld class biomedical research

• Development of innovative,interdisciplinary and cuttingedge programmes of research

• Provision of the intellectualenvironment and physicalfacilities for high quality training

• Development of partnershipswith neighbouring NHS Trustsand local communities in eastLondon to build researchcollaborations which addressthe health needs of our localpopulation.

The Centres are closely allied tothe large clinical departmentswithin Barts and The London NHSTrust and the priorities of the localPrimary Care Trusts.

We aim to build a pipeline ofactivity from basic science,clinical research and translationalmedicine to develop improvedmethods of diagnosis,management and therapy ofdisease with particular relevanceto the clinical activity of Barts andThe London NHS Trust and to thebenefit of our local population ineast London.

The geographic location of theBICMS and its close liaison withprimary care and NHS Trustsprovides an excellent opportunityfor the development oftranslational medical research.Clinical academics in the BICMSare championing these links withthe recently awarded NE LondonDiabetes Local Research Network(LRN), Medicines for ChildrenLRN (joint with GOSH), a hub ofthe Thames Stroke LRN, a spokeof the North Thames Dementiaand Neurodegenerative DiseasesLRN, and the relocation of theHPA Mycobacterial ReferenceUnit from King’s College London.

Blizard Institute of Cell and Molecular Sciencewww.icms.qmul.ac.uk

12 Barts and The London School of Medicine and Dentistry

Blizard Institute of Cell and Molecular Science

All BICMS Centres and Groups arehoused in the Blizard Building, a£44 million purpose-builtdevelopment in Whitechapel. Thisunique, award winning, researchbuilding provides state-of-the-artlaboratory accommodation basedon an innovative open plan designfor 400 staff and postgraduatestudents. The laboratory facilitiesare located on a single laboratoryfloor of approximately 3,500 m2,the design of which aims toencourage maximal interactionbetween different research groupsand cost efficient usage of coreequipment and facilities. TheBICMS has also benefited from £4 million investment from QueenMary for equipment which hasenabled the establishment of corefacilities in Genomics (jointly withthe Genome Centre atCharterhouse Square) FlowCytometry, Imaging, Transgenicsand a global siRNA screeningfacility all of which are equippedto a high standard with the latesttechnology.

Staff of the Institute were returnedunder two Units of Assessment:UoA4 (Other Hospital basedsubjects) and UoA10 (Dentistry).

Over 60 staff were returned inUoA4 and 80 per cent of ourresearch activity in this return wasjudged to be 4*/3*. In terms ofnational rankings, this placed theInstitute first equal (withCambridge) out of a total of 28submissions.

In UoA10, 75 per cent of ourresearch activity was rated 4*/3*which placed the School firstequal (with Manchester) out of 14returns from UK Dental Schools.

The annual research income ofthe Institute in 2008/9 was inexcess of £13 million and majorresearch funders include theMedical Research Council, theBiotechnology and BiologicalSciences Research Council, theWellcome Trust, Cancer ResearchUK and the Leukaemia ResearchFund.

Research findings from theInstitute are frequently reported inthe national media, including thediscovery of the genetic causes ofskin disease and diabetes.

Postgraduate programmes are an important element of theacademic activity of the BICMSand we currently offer:

• Postgraduate Certificate in Non-Invasive Aesthetic Techniques

• Postgraduate Diploma in Aesthetic Surgery

• Postgraduate Diploma in Burn Care

• Postgraduate Diploma in Clinical Dermatology

• MSc/Postgraduate Diploma in Clinical Microbiology

• MSc in Diabetes

• MSc/Postgraduate Diploma in Gastroenterology

• MSc/Postgraduate Diploma inTranslational Neuroscience

These programmes havedeveloped in response to theresearch teaching and trainingneeds of individuals pursuingcareers in disciplinesencompassed by the Institute.Each programme has a uniquestructure designed to best meetthese needs.

The Blizard Building also houses abioscience education centre, theCentre of the Cell, which aims toengage young people and schoolsin the principles of scientific andbiomedical research and thebackground to many of the majorscientific and ethical issues facingyoung people, educationally andsocially. The practical work beingdone by researchers in the BICMSand elsewhere in the Medical andDental School is showcased in thisunique educational facility.

Centre for Cutaneous ResearchThe Centre for CutaneousResearch is one of the largestacademic dermatology groups inEurope. Research within theCentre is currently organised intodistinct programmes, which bringtogether a critical mass of clinicaland non-clinical researchersunder the current themes:

• Cancer biology

• Genetics

• Stem cells

• Epithelial differentiation and barrier formation

• Burns and wound repair


Major achievements within theCentre include:

• Mechanistic evidence for thecarcinogenicity of theimmunosuppressiveazathioprine in skin, revealing atherapy-related cancer risk.

• Evidence for humanpapillomavirus (HPV)modulation of AKT signalling,and a possible role for AKT2 insquamous cell carcinoma(SCC).

• The genetic and molecularmechanisms underlying basalcell carcinoma (BCC).

• That Axl is a novel marker ofsquamous cell carcinoma.

• ABCA12 as the gene for thesevere congenital skin diseaseHarlequin Ichthyosis resulting inthe development of rapid pre-natal screening for affectedfamilies.

• RSPO4 as the gene foranonychia, therefore a key rolefor the Wnt pathway in naildevelopment.

• Translational research intoidentification of novel newpolymers to support tissueengineered skin andcharacterisation of survivalcharacteristics of engineeredskin on patients.

• Development of a Burnsnetwork.

• Promotion of cell migration byhypoxia via metalloproteinase-9and phosphorylation of focaladhesion kinase in keratinocytemigration on matrix.

• A signalling role for cadherins ofthe epidermal desomosome andthe role of AKT signalling and itsdownstream pathway in skinbarrier formation.

• The first description of a nongap-junction functional role forconnexin 31.

Centre for DiabetesThe Centre has a major interest ingenetic susceptibility to diabetesand related disorders. Barts andThe London is at the forefront ofthe international gene discoveryprograms in these disorders(including genome-wideassociation scans, candidategenes, functional genomics andprevention strategies). In addition,the Centre has an ongoingprogramme of research intoepigenetic influences on diabetesdevelopment. Clinical research isunderpinned by: DOH funded NELondon Diabetes Local ResearchNetwork; prevention initiatives intype 1 diabetes; LADA; type 2diabetes (T2D) focusing on thelocal Bangladeshi population.

Current research is focused in thefollowing areas:

• Genetics and diabetes

• Insulin action and secretion inmetabolic and cardiovasculardisease

• Inositide signalling

• Stem cells


• Discovery of novel genesassociated with T2D using a

genome wide association scanand the first evidence of gene to gene interaction increasingsusceptibility to disease.

• A landmark study (CARDS)demonstrating the feasibility of primary prevention ofcardiovascular disease in T2Dusing a statin.

• Establishing the role of thepyruvate dehydrogenase kinasesin the control of the function ininsulin-sensitive tissues and inpancreatic beta cells.

• Identification of a novelsignaling pathway important forinsulin action in muscles andadipocytes

• Identification of the critical roleof the enzyme phospholipase Cgamma1 in metastasisdevelopment.

Centre for Digestive DiseasesThe newly formed Centre forDigestive Diseases undertakesresearch and teaching into allaspect of the gastrointestinal tract,liver and nutrition. The Centre wasestablished in 2009 and bringstogether the former Centres forGastroenterology and AcademicSurgery. In so doing the Centre isdirectly aligned to the DigestiveDiseases Clinical Academic Unit(CAU) at Barts and The LondonNHS Trust.

The Centre is one of the very fewunits that undertakes research inboth paediatric and adult disease.It is organised as a researchcommunity with principalinvestigators grouped into major



interdisciplinary research groupsencompassing: epithelial cellbiology; infection, immunity andinflammation; hepatology;neurogastroenterology; ano-rectalphysiology; colorectal cancer andcolorectal surgical development

The Gastrointestinal PhysiologyUnit, an integral part of the Centreand national referral centre,develops new investigations ofcolorectal function. Reconstructivesurgery is conducted in theColorectal Development Unit,established in 1997 with NSCAGfunding.

There is a longstanding traditionof research inneurogastroenterology within theCentre, established by ProfessorDavid Wingate in the 1970s. Thisgroup is housed in a purpose builtfacility, the Wingate Institute andis closely linked with theneurogastroenterology interests ofthe Academic Centre of Surgery.


• Establishing the field of nutritionand gene regulation in theintestine, particularly epigeneticregulation

• Identification that thechromosomal region harbouringIL1 and IL21 underlies thesusceptibility to coeliac diseaseusing a genome wideassociation scan

• Elucidating the mechanism bywhich Dengue and Hepatitisviruses inhibit interferonsignalling

• Discovering the centralimportance of interferongammain the intestine resistance toinfection with Cryptosporidium

• Developing a new vaccineplatform to immunize againstviruses

• Cerebral imaging of visceralpain; and elucidation of painneuronal pathways from theupper GI tract in order toidentify new therapeutic targets.

The Centre also teachesgastroenterology, hepatology and nutrition to undergraduates.Postgraduate teaching isundertaken in the MScProgramme in Gastroenterology.

Centre for Immunology and Infectious DiseaseThe Centre includes researchgroups investigating cutting-edgetopics in microbiology, virologyand immunology. Full details canbe found on our websitehttp://www.icms.qmul.ac.uk/centres/immunologyandinfectiousdisease/index.html.

Investigators in the centre receiveblue-chip funding from MRC,Wellcome Trust, BBSRC andEUFP7, and publish in topjournals. At mucosal surfacessuch as the mouth and the gutthere is intimate associationbetween the immune system, food antigens, and the residentcommensal bacteria. Severalgroups are investigating how thisrelationship is regulated in health,what goes wrong in inflammatorydiseases such as Crohn’s diseaseand periodontitis, and how theimmune system distinguishesbetween pathogens and thenormal microbiota. Studiesinclude understanding mucosal Tcell biology in health and disease,how dendritic cells modulate T-cell activity, the development ofunconventional T-cells, andanalysis of bacterial surfacemacromolecules.

People who settle in east Londoncome from many parts of theworld, where TB (Mycobacteriumtuberculosis) and AIDS (HIV) areendemic. We investigatepathogenic mechanisms, newdrug targets, and strategies forimproved disease prevention inboth of these globally important


infections. We host the HealthProtection Agency NationalMycobacterium Reference Unitwhich contributes to the Centre’sresearch strength on this topic.We also investigate epidemiologyand pathogenic mechanisms ofother organisms includingvaricella zoster virus,Pseudomonas aeruginosa, andStreptococcus pneumoniae.

Resistance to antibiotics andantiviral agents presents a majorchallenge to modern medicine.We study the molecular andgenetic mechanisms of resistanceto antimicrobials, how resistancespreads, and novel strategies forcombating resistance. Particularstrengths are in drug resistant HIVand multiply antibiotic resistantgram negative bacteria.

Centre for Neuroscience and TraumaThe Centre has eighteenacademic staff and research isfocused on three interrelatedtopics: Trauma;Neuroinflammation and pain;Neuro-oncology and genomics.

TraumaThe focus is on spinal cord and peripheral nerve injury andcoagulation. The group hasidentified several therapeuticstrategies to preventcomplications of injury, and tolimit and repair its damage.

Neuroinflammation and painThe main disease focus of theNeuroimmunology group ismultiple sclerosis. £5 million ofgrants is being used will be usedto research immune tolerancestrategies, developneuroprotective andneurorestorative therapies forprogressive multiple sclerosis andmanipulate cannabinoid biologyas a therapeutic strategy toimprove the symptoms of multiplesclerosis.

Neuro-oncology and genomicsResearch includes:

• A molecular and developmentalbiology approach in mousemodels which shows howcellular and molecularmechanisms control thedevelopment of the centralnervous system and cancontribute to braintumorigenesis whenderegulated.

• A study of the function ofhuman chromosomes and thegenetic basis of cancer, with the discovery of distinct higherorder chromatin configurationsand loop domains that aredependent on gene density and transcriptional activity.

Research also focuses on critical pathways involved in tumorigenesis, with an emphasis on brain tumours.

There are also active researchprogrammes in motor neuronedisease, pain, muscleregeneration, biomarkers andclinical outcomes.

Future objectives for the Centreinclude the establishment ofresearch and clinical units inspinal injury and neuroinfectiousdiseases and further developmentof basic research in CNS tumourbiology.

16 Barts and The London School of Medicine and Dentistry


Centre for PaediatricsThe Centre for Paediatricsfacilitates paediatrics research, aswell as Child Health teaching onthe MB BS programme. We workclosely with the paediatric clinicalservices provided by Barts andThe London (BLT), the secondlargest paediatric services inLondon (Barts and The LondonChildren’s Hospital).

The Centre regularly publishesscientific findings in journalsincluding, Nature, NatureGenetics, New England Journal of Medicine and The Lancet.Research in Paediatrics isorganised into the followingthemes:

HaematologyThe principal research interest isbone marrow failure focusing onthe pathophysiology of theinherited bone marrow failuresyndromes, particularlydyskeratosis congenita (DC).Studies are also being undertakenon other haematological disordersincluding: the pathophysiology ofmyelodysplasia/ leukaemia andthe establishment of a clinicalnetwork for sickle cell disease ineast London.

Neonatal MedicineA major initiative within NeonatalMedicine relates to investigation ofthe associations between low birthweight and airway function andthe underlying mechanisms. Otherareas of research include:

• The use of Doppler ultrasoundin the investigation of theneonatal circulation

• The mechanisms and control ofplacental transport of nutrientsfrom mother to foetus.

Respiratory and EnvironmentalMedicineMain research interests arepaediatric asthma, and the impactof environmental pollutants on thedeveloping lung. An environmentalresearch group is studying thecellular and molecularmechanisms underlying theincreased vulnerability topneumococcal pneumonia inchildren exposed to particulate air pollution.

Down’s syndromeProfessor Nizetic utilises afunctional genomics approach tothe study of effects of gene dosein human aneuploidy with anemphasis on Down’s syndrome asa model. In particular, gene doseeffects of trisomy of humanchromosome 21 on embryonicstem cell differentiation and cellfate, and myeloid stem celllineages in relation to childhoodleukaemia in Down’s syndromeare under investigation. The workinvolves gene expression arrays,proteomics and potentially ZFtransgenic modelling.

Pathology GroupThe focus of this group is the exploration of cellularpathogenesis. Members areexperts in the morphologicalaspects of disease, gene andprotein expression in health and in disordered function eg cancer,inflammation and trauma.Members of the group play a largeand important role in the ongoingteaching programmes across themedical and dental schools, andplay an integral role in theresearch of groups in Pathology aswell as other centres. Major linksexist with groups working ingastroenterology, cancer,neurosciences, cutaneous andchild health.

The Academic Haematology Unithas developed from a broadclinical base and particular areasof clinical excellence includinghaematological malignancies andautoimmune thrombocytopenia(ATP). The ATP research has ledto the development of particularexpertise in flow cytometry underProfessor Marion Macey and across Centre interest inautoimmune disorders.

Other research interests lie ingene therapy for haemophilia,molecular pathology of vonWillebrands disease, the linkbetween cancer and thrombosisand the mechanisms of inhibitordevelopment in haemophilia A.


Senior staff research interestsBlizard Institute of Cell and Molecular Science

Malcolm Alison PhD(Newcastle)DSc(Newcastle) FRCPath(Lond) Professor of Stem Cell Biology,Centre Lead for DiabetesProfessor Alison’s researchfocuses on stem cell biology inhuman pancreas, liver and gut in both health and disease,specifically fibrosis and cancer.Through searching for cellsdeficient in mtDNA-encodedcytochrome c oxidase (COX), wecan map the movement of cellsthrough tissues, and can establishthe monoclonality of COX-deficientpatches by whole mtDNAsequencing of laser-capturedcells. The technique allows us toinfer the location of the stem cellniche. Using human pancreaticcancer cell lines, we are studyingthe clonogenicity of specific sub-populations such as the SP andALDHbright fractions, andexploring the roles of trefoilpeptides in tumour progression.The group is also studying the roleof bone marrow-derived cells(BMDCs) in pancreatic and gutdisease, specifically thecontribution of BMDCs to chronicpancreatitis in animal models withcerulein treatment and an IL-10KO background.

Qasim Aziz PhD FRCPProfessor ofNeurogastroenterologyProfessor Aziz’s major researchinterest is to study themechanisms of visceral pain inhealth and disease. His work has contributed to the currentunderstanding of the brain neuralnetwork involved in processinghuman visceral pain usingfunctional brain imagingtechniques and has demonstrated

the role of psychological factors inmodulating this network. He hasstudied the role of inflammation /injury in sensitising visceral nervesleading to pain and is currentlystudying psycho-physiologicalfactors causing inter-individualvariability in pain perception inhealth and patients withFunctional GastrointestinalDisorders. Other researchinterests include theneurophysiological mechanisms ofnausea and the link between JointHypermobility Syndrome andgastrointestinal symptoms.

David Baker BSc PhDProfessor of NeuroimmunologyProfessor Baker’s researchinterests have focused onexperimental delayhypersensitivities most notably inthe brain where his research hasfocused on understanding andcontrolling established immuneresponses. Aspects ofimmunological tolerance inductionin the skin initiated during PhDstudies were adapted for studiesfor the control of autoimmunity ofthe central nervous system andare being developed for thecontrol of immunity in multiplesclerosis. This follows on from thedevelopment and characterisationof novel models of multiplesclerosis. His research hasspanned many areas ofimmunobiology including,immunopathology, cytokinebiology, blood brain barrierdysfunction; myelin autoantigens,genetic mapping of disease, genetherapy and immunologicaltolerance induction in establishedimmune responses. Most recentlyhe has been involved in

understanding the involvement of the cannabinoid system insymptom control,neurodegeneration and immunityas they relate to multiple sclerosis,as well as the development ofagents for the treatment ofchronic neurogeneration andsymptom control.

David Beach PhD FRSProfessor of Stem Cell BiologyProfessor Beach's research is focused on the molecularpathways that regulate theproliferation and fatedetermination of human and othermammalian cells in particular, themechanisms of cell cycle controland cellular senescence. Furtherareas of investigation concern thegenetic mechanisms by whichnormally proliferating cellsbecome oncogenicallytransformed when the regulationof pathways affecting cellularsenescence, anchoragedependence, motility andangiogenic activation becomealtered. His group is alsointerested in the biology of stemcells: by studying the unusual cellcycle regulatory mechanisms ofboth embryonic and adult stemcells, they will gain anunderstanding of how growthpotential becomes restrictedduring normal development andwill define the role of adult stemscells in the development andmaintenance of tissues andorgans.

Karim Brohi FRCS FRCAProfessor of Trauma SciencesKarim Brohi is the lead forresearch for the Trauma ClinicalAcademic Unit at Barts and The

and led the international efforts to implement the MinimumInformation for Publication ofQuantitative Real-Time PCRExperiments (MIQE) guidelines.Professor Bustin has written andedited two books on PCR,published the most-cited reviewarticle on this topic (approaching1,600 citations) and is playing acentral role in defining the use ofthis technology as a clinicaldiagnostic tool.

Carolyn Byrne BSc PhD(Sydney)Professor of Skin BiologyProfessor Byrne is interested inhow the skin barrier preventsmicrobial assault and ultravioletdamage. The skin barrier residesin both the epidermal stratumcorneum and the underlyingadhesion complexes. ProfessorByrne’s group is interested in theregulation of epidermalkeratinocyte differentiation andskin barrier formation during fetaldevelopment, and the role andregulation of specific classes ofskin barrier proteins (LCEproteins) that are differentiallyexpressed and responsive toultraviolet B. The group has latelyfocused on the PI-3kinase-AKTpathway with the proposal that itpleiotropically regulates skinbarrier formation. The group hasshown that this pathway is atarget of environmental influencessuch as viral infection andultraviolet radiation causingbarrier compromise. AKT kinasesare also differentially alteredduring skin carcinogenesis andwith clinical collaborators we areinvestigating the role this pathwayplays in skin tumour progression.

London NHS Trust. Researchwithin the Trauma Group coversthe breadth of the traumasciences, from injury preventionand public health, the effects oftrauma and the body’s responsesto injury and through all stages ofmanagement through torehabilitation.

A strong focus of the research has been the identification andcharacterisation of AcuteTraumatic Coagulopathy, and thedevelopment of experimentalmodels to explore new diagnostictools and therapeuticinterventions. We received £2million funding from the NationalInstitute of Health Research tocontinue our research in the fieldof trauma coagulopathy andmassive transfusion inconjunction with the NationalBlood Service.

Along with other academicpartners, the group is alsodeveloping a systems biologymodel to haemostasis.

Stephen Bustin BA PhD(TCD)Professor of Molecular ScienceProfessor Bustin's main researchinterests focus around threeresearch themes: the role ofdietary, hormonal and growthfactors in colorectal cancertumorigenesis, development ofmolecular diagnostic assays forthe detection of nosocomialinfections and the standardisationof real-time PCR technology fornucleic acid quantification. Mostrecently his group hasinvestigated a newly identifiedmolecular mechanism underlyingthe protective effects of vitamin D



Kathleen Costeloe MB BCHirFRCP FRCPCHProfessor of PaediatricsA major initiative within NeonatalMedicine relates to investigation ofthe associations between low birthweight and airway function andthe underlying mechanisms. Thishas necessitated long termcollaborative studies involvingneonatologists from Barts and TheLondon (Professor Costeloe, DrHusain and Dr Kempley) andfrom other institutes (ProfessorDezateux and Professor Stocks).Important contributions includethe documentation of outcome invery premature infants in the UKand how this is changing withmodern interventions.

Nick Croft MB BS(Lond)PhD(Edin) DCH(Glas) MRCPFRCPCHReader in Clinical PaediatricGastroenterologyDr Croft’s research interests are based around clinical andtranslational research focusing on paediatric gastroenterologicaldiseases such as inflammatorybowel disease, coeliac disease,food allergy, gastro-oesophagealreflux and gastrointestinalinfections. This has recentlyincluded examining theunderlying genetics of growthfailure in IBD, the growthresponse to enteral nutrition inchildren and the phenotype ofIBD in children and adults. He isa co-director of the London andsouth east medicines for childrenlocal research network whichsupports the development andrunning of trials of treatments inchildren. He is also the co-Chairof the UK Paediatric


Gastroenterology, Hepatology and Nutrition Clinical StudiesCommittee. Dr Croft’s mainteaching role lies in organising the MSc and Diploma inGastroenterology which supportsresearch through projects run aspart of the taught programme, aswell as attracting quality studentsto study for higher degrees. As amember of the HumanDevelopment Systems planningunit he is a member of theundergraduate paediatric teachingteam.

Mike Curtis BSc(Bris) PhD(Lond) Professor of Microbiology, Directorof Blizard Institute of Cell andMolecular ScienceProfessor Curtis’s current researchis focused in two main areas.First, the cell surfacepolysaccharides, lipo-polysaccharides and proteolyticenzymes of Porphyromonasgingivalis, one of the keypathogens in periodontal disease,are key virulence determinantsand play important roles in boththe persistence of this bacteriumin chronic disease and itsinteraction with the immune andinflammatory systems of the host.In MRC funded studies, we areusing biochemical and classicalgenetics approaches to determinethe structure and biosyntheticpathways of thesemacromolecules. The second areaof research, funded through theNIH, aims to determine the role of the commensal bacteria in thedevelopment of the innateimmune response andmaintenance of health in the oraltissues. These studies involvecomparative molecular analysis of

periodontal tissues from germ freeversus conventionally reared miceand examination of the influenceof individual bacterial species onthe expression of markers ofhealth.

Inderjeet Dokal MBChB MD FRCPFRCPCH FRCPathChair in Child Health, Centre Leadfor PaediatricsProfessor Dokal’s main researchinterest is the pathophysiology ofaplastic anaemia/bone marrowfailure. In order to understand thebiology of aplastic anaemia (AA)he has focused on monogenicdisorders associated with AA. Thisincludes Dyskeratosis Congenita(DC) and Fanconi Anaemia (FA).He has had a close collaborationwith his colleague Dr TomVulliamy (Senior Lecturer inMolecular Biology) since 1995.They have elucidated the geneticbasis of several subtypes of DC.They have also demonstrated alink between DC and AA and thatthis group of disorders arise fromdefects in the enzyme telomerase.The main focus of currentresearch is to establish the

pathophysiology of the manyuncharacterised cases of DC and AA. Studies are also beingundertaken to explore thepossibility of correction oftelomere length in-vitro as thismay represent a new therapeuticapproach for DC/AA patientsfailing conventional therapies. The group also has a clinical andresearch interest in other geneticdisorders associated with bonemarrowfailure/myelodysplasia/leukaemia.

Paola Domizio BSc MB BSFRCPathProfessor of Pathology Education,Teaching Lead, Blizard Institute ofCell and Molecular ScienceProfessor Domizio is Professor of Pathology Education andHonorary Consultant inHistopathology. Her major fields of interest are medical educationand gastrointestinal pathology, inwhich she has a nationalreputation. For many years shehas been Director of Pathologyteaching at Barts and TheLondon, but also has a wider rolein curriculum development and



management and runningexaminations. Professor Domiziois currently Lead Teacher for theBlizard Institute of Cell andMolecular Science. She is anexternal examiner for severaluniversities and also examines forthe Royal College of Pathologistsand the Royal College ofSurgeons. She has also heldseveral positions of responsibilityin relation to postgraduateeducation, including educationalsupervisor and regional adviser inpostgraduate education.

Sina Dorudi BSc MB BS PhDFRCS FRCS(Gen)Professor of Surgical OncologyProfessor Dorudi’s clinicalresearch interests are in surgicaltraining, pelvic cancer surgeryand inflammatory bowel disease.His research interests centrearound detailed prognosticstratification of colorectal cancerpatients using microarraytechnology and the investigationof host-immune responses incolorectal cancers. His researchhas focused on the use anddevelopment of high throughputassays to distinguish between thewell-delineated colorectal cancerphenotypes. A key aim of thisresearch programme is to stratifypatients with colorectal cancer bytheir identified developmentalpathway for more accurateprognosis and to identify patientswith chemo-resistant disease forthe purposes of tailored therapy.His postgraduate educationinterests have centred on thedevelopment of multimediasimulation platforms for training in operative colorectal surgery.

Francis Drobniewski MA(Dub)MSc MB BS(Lond) PhD(Cantab)DTM and H FRCPathProfessor of Tuberculosis andMycobacterial Diseases, Directorof the Health Protection AgencyNational MycobacteriumReference Unit (MRU),Consultant Microbiologist and TBPhysicianThe research interests of theClinical TB and HIV Group andthe UK Health Protection Agency(HPA) National MycobacteriumReference Unit (MRU) relate to all aspects of tuberculosis,international public health, AIDSand opportunistic infections.Specifically the group focuses on the diagnosis, and molecularepidemiology of tuberculosis and other mycobacteria, theunderstanding drug resistanceand disease tropisms, host-pathogen interactions and theinterplay between TB and HIV

and broader public healthproblems posed by these diseasesboth in the UK and overseas. Staffalso work outside the laboratoryon collaborative internationallaboratory and public healthtopics relating to TB and HIV inRussia and Ukraine currently and in partnership with severalcountries in Africa. We have aninternational group with one-thirdcoming from overseas and mainresearch collaborations withgroups in the UK, USA, Russian,Italy, Germany, Sweden, Malawi,Zambia, South Africa, Argentina.

Marco Falasca Professor of MolecularPharmacologyProfessor Marco Falasca workswith the Inositide Signalling Groupfocusing on the role ofphosphoinositides and theirregulatory enzymes in humandiseases such as diabetes and

21Barts and The London School of Medicine and Dentistry

cancer. Phosphoinositidescomprise a family of eightmembrane lipids which playimportant roles in many signaltransducing pathways in the cell.Indeed, phosphoinositides aresources of the secondmessengers, diacylglycerol,inositol(1,4,5) trisphosphate andphosphatidylinositol (3,4,5)trisphosphate. Signaling throughvarious phosphoinositides hasbeen shown to mediate cellgrowth and proliferation,apoptosis, cytoskeletal changes,insulin action and vesicletrafficking. A number of advancesin signal transduction in the lastdecade have resulted in thediscovery of a growing list ofproteins which directly interactwith high affinity and specificitywith distinct phosphoinositides.These interactions occur throughspecific phosphoinositide bindingdomains such as the pleckstrinhomology domain. Researchprojects are particularly focusedon the signaling pathwaysactivated by phosphoinositide 3-kinase, phospholipase C andlysophospholipids.

Graham Foster BA(Oxon) MRCPFRCP PhDProfessor of HepatologyProfessor Foster has researchinterests in the clinical andscientific aspects of chronic viralhepatitis, which is the major focusof the Liver Unit at Queen Mary.Clinical research programsinclude an assessment of thedisease burden in ethnic minoritygroups - the unit is co-ordinatinga Department of Health fundedstudy looking at the prevalence ofviral hepatitis throughout the UK.

The Liver Unit has a very activeclinical trials program and clinicalresearch projects include studiesof novel antiviral agents for themanagement of chronic hepatitisC are in progress as well asstudies evaluating the factorsresponsible for changes in therate of fibrosis progression inpatients with chronic hepatitis C.The Liver Unit runs a successfullaboratory research programstudying novel replication systemsfor the hepatitis C virus and theimmune response to viral hepatitisinfections. Studies to identify hostand viral factors that determinethe response to therapy withchronic hepatitis B and chronichepatitis C are in progress.

Gavin Giovannoni MBBCh PhDFCP(Neurol) FRCP FRCPathProfessor of Neurology, CentreLead for Neuroscience andTraumaProfessor Giovannoni’s researchand clinical interests includeMultiple Sclerosis (MS) and otherinflammatory disorders of the

central nervous system. ProfessorGiovannoni runs a MS clinicaltrials unit and is the principalinvestigator on several phase IIand III MS trials. Other interestsinclude biomarker discovery, forstudying the pathogenesis of MSand to establish predictive testing.Professor Giovannoni believes thelatter will become increasinglyimportant in the future to identifypatients most likely to respond todisease-modifying therapies, toselect patients for clinical trialsand to assess individual’sresponse to treatment. He isparticularly interested in issuesthat relate to optimising MSdisease modifying therapies andparticularly the impact andimmunology of neutralising anti-interferon beta antibodies. Heruns a specialist clinicalneuroinflammatory service and aresearch group investigating bothbasic science and clinical aspectsof MS. Other research interestsinclude antibody mediatedautoimmune disorders of thecentral nervous system.



Stephen Greenwald BA(Oxon)PhD(Lond)Professor of CardiovascularMechanicsProfessor Greenwald’s researchinterests include a search formechanical factors in the genesisof arterial disease, with emphasison the role of fatigue failure inarterial elastin, foetal programmingof essential hypertension andwave propagation in arteries. Thelink between the elastic propertiesof arteries, pulse pressure and themechanical load on the heart isnow thought to be the explanation,at least in part, for the widelyrecognised association betweenraised vascular stiffness andincreased risk of cardiovascularmorbidity and mortality.

On the applied side, ProfessorGreenwald’s interest in arterialmechanical properties has lead to studies evaluating the efficacycompliant intravascular stents andthe development of a novel opticalmethod for the non-invasivemeasurement of arterialcompliance. The possibility ofapplying similar optical techniquesto the measurement of cardiacoutput and the assessment ofendothelial function is now underactive investigation.

Jonathan Grigg BSc MB BS MDMRCP FRCPCHProfessor of Paediatric Respiratoryand Environmental MedicineProfessor Grigg's researchinterests are paediatric asthma,and the impact of environmentalpollutants on the developing lung.Drawing on a new method ofassessing individual exposure ofchildren to air pollution, his

environmental research group are studying the cellular andmolecular mechanisms underlyingthe increased vulnerability topneumococcal pneumonia inchildren exposed to particulate air pollution. His clinical researchgroup, in close liaison with theNHS service, is developing newtherapies targeted at airwayinflammation in asthma and cysticfibrosis.

Lucinda Hall BA(York) MSc(Lond)PhD(Glas)Reader in Molecular Microbiology,Centre Lead for Immunology andInfectious DiseaseLucinda Hall’s research group is exploring the genetic andevolutionary mechanisms bywhich bacteria respond to medical interventions such as the widespread use of antibiotics.Previous work has included thedescription of mechanisms ofantibiotic resistance andinvestigation of bacterialpopulation structure, as well as collaborative work with MA Curtis on a virulence factor in the periodontal pathogenPorphyromonas gingivalis. Thegroup’s current projects involvemutational mechanisms andgenome rearrangements inStreptococcus pneumoniae, and the factors mediating thepersistence of sulphonamideresistance in Escherichia colidespite dramatically reducedprescribing. The group is alsoinvestigating the response of thegut microbiota to treatment ofCrohn’s disease by enteralfeeding, in collaboration withcolleagues in the Centre forGastroenterology. This forms part

of a developing strategy within CIDto understand the interactionsbetween microbiota and the hostimmune system.

Graham Hitman MB BS MDFRCP(Lond)Professor of Molecular Medicineand Diabetes, Deputy (Research)Head Blizard Institute of Cell andMolecular Science, Clinical Leadof the North East London DiabetesLocal Research NetworkProfessor Hitman’s main interestsare directed to gene discoveryarising from genome-wideassociation scans in type 2diabetes and the use ofepigenetics to study the geneenvironmental interaction. He is also one of the principalinvestigators of the CARDS(Collaborative AtorvastatinDiabetes Study) trial that hasinfluenced the development ofcurrent lipid lowering guidelines in diabetes and is a principalinvestigator of two pilot diabetesprevention trials one of which isan RCT of vitamin Dsupplementation. He has almost200 peer reviewed publicationsand is currently Editor-in-Chief of Diabetic Medicine.

Virginia Hubbard MB BSMSc(MedEd) MRCPProgramme Director forPostgraduate Diploma in ClinicalDermatology (InternationalProgramme), Honorary ConsultantDermatologist at HomertonUniversity Hospital NHSFoundation TrustDr Hubbard’s academic interest is Medical Education, with aparticular focus on E-learning. She is programme director for the


Postgraduate Diploma in ClinicalDermatology (InternationalProgramme), and is activelyinvolved in the education ofundergraduates and chairs an E-learning group within the MedicalSchool.

Victoria ML Jolliffe MA(Cantab)MRCP FRCS(Ed) MRCGP ARCMDirector of Postgraduate Diplomain Clinical Dermatology, HonoraryConsultant Dermatologist andClinical Senior Lecturer, Centre for Cutaneous ResearchDr Jolliffe is a clinical academicwho is Programme Director for thePostgraduate Diploma in ClinicalDermatology for UK students. Incollaboration with Dr VirginiaHubbard, she has developed thediploma into a web-basedblended learning programmeencompassing E-learning via web-CT, clinical DVDs and Clinical

are the major cause of genetichearing loss worldwide. Hisstudies then focused on humangenodermatoses and theimportant role of proteins involvedin epidermal cell junctionsincluding gap junctions. Hiscurrent studies include thecellular functions of connexins,genetic and functional studies ofdesmosomes in skin disease andcardiomyopathy, and the role ofABCA12 in the devastating skindisease Harlequin Ichthyosis.

‘‘‘‘Staff profile:David Kelsell BSc PhD, Professor of HumanMolecular Genetics

The main focus of my research group is theidentification of the genetic and molecularmechanisms underlying skin disease though myresearch also includes investigating genesimportant in cardiomyopathy and hearing loss.Examples of skin diseases include atopic eczemain the local Bangladeshi community and the rarebut devastating condition Harlequin Ichthyosis. Ina more quirky study we identified the first geneassociated with nail development.

I’m proud to have identified a number of genes important in skin conditions,cardiomyopathy and hearing loss, and we arelucky to have state-of-the-art genetic and

molecular facilities that allow studies to be done that were impossible a few years ago.

I teach genetics to the undergraduates and have a number of postgraduate students studying for PhDs. I’ve enjoyed the fact that a number of the medical students have worked in my lab either as part of a module or for experience.

Teaching Days with patient casesand interactive tutoring. Researchinterests include the use of digitalimaging in patient triage anddiagnosis and the widerapplications of teledermatology.

David Kelsell BSc PhDProfessor of Human MolecularGeneticsProfessor Kelsell's main researchfocus is the identification of thegenetic and molecularmechanisms underlying epidermaldisease. His PhD involved geneticstudies to identify the two breastcancer genes, BRCA1 andBRCA2 and their importance infamilial and sporadic breastcancer. Publications include alandmark paper in Nature,identifying Cx26 mutationsassociated with non-syndromichearing loss, leading to thediscovery that Cx26 mutations



Parveen Kumar CBE BSc MD DMFRCP FRCP(E)Professor in Medicine andEducation, Vice-Chairman MSc in GastroenterologyProfessor Kumar is not only a veryexperienced gastroenterologist butalso one of Britain's leadingmedical educators. She isProfessor of Medicine andEducation at Barts and TheLondon and is highly appreciatedas a teacher by students in theUK and abroad. She is co-authorof one of the world's mostsuccessful textbooks in medicine,Kumar and Clark's ClinicalMedicine (7th edition, 2009Elsevier) as well as many otherbooks. She has been the Vice-President of the Royal College ofPhysicians (where she establishededucational programmes andintroduced online ContinuingProfessional Development),President of the British MedicalAssociation and Chairman of theMedicines Commission UK and is currently President-Elect of theRoyal Society of Medicine. Sheestablished the first MSc inGastroenterology in the UK in1992.

David Leslie MB BS MRCS MDFRCPProfessor of Diabetes and AutoimmunityDavid Leslie’s research involvesstudies using major patientresources (such as patients withadult-onset autoimmune diseaseand twins with diabetes), andmolecular studies on these casesincluding collaborations with theHuman Epigenome Consortiumand the NIH in America. Recentstudies have led to identification

of a genetic component to proteinglycation using healthy anddiabetic twins and thecharacterisation of latent onsetdiabetes of the adults following a major multi-million pound EUgrant to Professor Leslie. Recentstudies have led to thedevelopment of novel vaccination-type therapies to limit the diseaseprocess in type 1 diabetes whichare now proceeding to Phase 3studies.

Professor Leslie is an editor ofDiabetic Medicine and on theboard of Diabetes MetabolismResearch and Reviews.

Kenneth Linton BSc(Edin)PhD(Glas)Professor of Protein BiochemistryThe Membrane Transport Biologygroup are funded by the MRC,Diabetes UK and Novartis toinvestigate the relationshipbetween the structure andfunction of transport proteins incellular membranes, and how thisrelates to human physiology anddisease. Three classes ofmembrane proteins are studied:(1) the ATP Binding Cassettetransporters ABCB1, B4 and B11;(2) the scavenger receptor CD36;and (3) the fatty acid transportproteins or FATPs. ABCB1, amultidrug resistance pump, is animportant determinant of barrierfunction at the cellular and tissuelevel and can confer multidrugresistance on cancer cells. Theclosely related ABCB4 and B11proteins are responsible for thetransport of lipids and bile salts,respectively, into the bile duct(mutations of either cause a rangeof cholestatic liver diseases). The

scavenger receptor CD36 is apolyspecific receptor of, amongothers, oxidised LDL andthrombospondin. It is implicatedin atherosclerosis, fibrosis andtumour angiogenesis. FATPs areimportant for the uptake andcatabolism of long chain fattyacids and implicated in thedevelopment of diabetes and skin disease.

Thomas MacDonald BScPhD(Glas) FRCPath FMedSciProfessor of Immunology, Dean for ResearchProfessor MacDonald is interestedin the way in which the gutimmune system functions inhealth and disease, particularlyinflammatory bowel disease andcoeliac disease. He also has agrowing interest in how gutbacteria manipulate gut immunity.

Ian Mackenzie BDS FDSRCS PhDProfessor of Stem Cell ScienceIan Mackenzie's groupinvestigates various aspects of thebiology of normal and malignantsomatic stem cells with support of the MRC/NC3Rs, BBSRC, andcancer charities. Areas of majorinterest include (a) the role ofstem cells in the generation andgrowth of epithelial malignancies,(b) the nature of molecular andphenotypic differences betweenmalignant stem and amplifyingcells, (c) the effects of suchdifferences on therapeuticresistance and stem cellresponses to therapeutic agents,and (d) the significance ofepithelial-mesenchymal transitionoccurring within malignantpopulations.


Further areas of interest are (a)the roles of connexin expressionin the maintenance of the stemcell phenotype, (b) mechanismsassociated with transition of stemcells into defined differentiationpathways, and (c) thedifferentiation of mesenchymaland embryonic stem cells intoepithelial lineages.

Silvia Marino MDProfessor of NeuropathologyThe focus of Professor Marino’sresearch group is on molecularmechanisms controlling thedevelopment of the centralnervous system and on how thesevery same mechanisms cancontribute to tumourigenesiswhen deregulated. Their work ismainly centred on the biology ofneural stem cells and neuralprogenitor cells, on the pathwaysand genes involved in control oftheir proliferation anddifferentiation, in particular theSonic Hedgehog pathway and thePolycomb group genes. Moreoverthe group is investigatingpathways and molecularmechanisms involved in theformation, development andprogression of brain tumours in experimental models and inhuman tumour samples.

Joanne Martin MA(Cantab) MBBS PhD(Lond) MA FRCPathProfessor of Pathology, DivisionalDirector – Clinical and DiagnosticServices, Head of BICMSPathology GroupProfessor Martin’s researchinterests lie in neurodegenerationrelated to motor neuron disordersand to motility disorders of thegut. Her team have identified anew method of drug delivery for

the treatment of a wide range ofconditions, including tumours.Other projects involve theinvestigation of smooth muscleand neuronal function in intestinalpseudo-obstruction, with thediscovery of the underlyingdisorder for a range of patientswith intestinal failure.

Aine McKnight MSc PhDProfessor of Viral PathologyProfessor McKnight’s researchfocuses on HIV/AIDS. HIV’senormous diversity makes vaccinedevelopment very challenging.HIV-1 group M viruses are dividedinto 10 clades (A to K). Circulatingrecombinant forms (CRFs) arisethrough recombination betweenclades within multiply infectedindividuals. Clade B is almostubiquitous in the Western world.East London is unique; the patientpopulation comes, and settles,from throughout Africa and Asiaresulting in a clade distributionreflecting worldwide distribution.This diversity affords us theopportunity to study how to tacklethe problem of cross cladevaccines. We have establishedclinical patient cohorts - such asthose who control viral replication,or do not progress to disease - tostudy the correlates of immuneprotection from AIDS.

A further research focus is oninnate anti-viral activities withinhuman cells that obstruct HIVreplication after cellular entrysuch as Lentiviral-restriction-factor-2, described by us.Currently Professor McKnight’sgroup is characterising this, andnew restrictions, and mapping thegene(s) responsible.

Adina Michael-Titus Lic Sci M esSci Doct en SciReader in Neuroscience and PharmacologyDr Michael-Titus has a researchprogramme focused on thedevelopment of newneuroprotective treatments withpotential in neurotrauma andneurodegenerative disease. She isan inventor of several patents andis currently focused on strategieswith significant translationalpotential. Her recent research has demonstrated the efficacy of erythropoietin analogs andpolyunsaturated fatty acids inneurotrauma. Her currentresearch is exploring thetherapeutic value of novel metal-binding compounds in spinal cordinjury and Alzheimer’s disease. Dr Michael-Titus is the GraduateTutor for the Centre forNeuroscience and Trauma andProgramme Director of the MSc in Translational Neuroscience.The programme will draw on theconsiderable strengths of theCentre for Neuroscience andTrauma in translationalneuroscience, to offer studentsspecialised training in thisemerging field.

Simon Myers PhD FRCS(Plast)Director of Postgraduate Diplomain Aesthetic Surgery, PostgraduateDiploma in Burn Care andPostgraduate Certificate in Non-Invasive Aesthetic Techniques,Clinical Senior Lecturer in PlasticSurgery and Wound Healing,Honorary Consultant PlasticSurgeonHaving completed a PhD inkeratinocyte growth anddifferentiation in wound healingand cultured keratinocyte grafting



within the CCR, Dr Myers hasspent some years as clinical leadfor the central London burnservice in Chelsea. Currentresearch priorities include theestablishment of a burn-careresearch network in the South-east of England, with a chair inburn care based at the BICMS,concentrating on the mechanismsof burn wound healing, thecomplications of burn injury, andtherapeutic interventions, andparticularly infection control andinnate immunity. Educationalprogrammes under developmentinclude a WebCT distancelearning postgraduate diploma inburn surgery, and an MSc inplastic and reconstructive surgery.

Harshad Navsaria BSc MSc PhDProfessor in Cell and TissueEngineeringProfessor Navsaria's maininterests are in the field ofkeratinocyte biology and tissueengineering. His current interestin the field of tissue engineering of skin is on the application ofstem cell technology and theidentification of stem cells, whichcan give rise to a keratinocytephenotype. The aim is to establisha stem cell centre within thecollege from different tissuedisciplines with an interest instem cell biology for translationalresearch. He is currently trying toestablish a licensed clean room toprovide a service for cell basedtherapies. His research group incollaboration with others is alsostudying epithelial/mesenchymalinteractions and identifying geneexpression in combination withvarious mesenchymal cell types in different skin pathologies andwound healing. The aim of the

work is to understand thedistinction between regenerationand repair of damaged skin.Professor Navsaria also has aresearch programme to establishinvitro sweat gland and 3D hairfollicle models. His group is alsoworking on Keloid andHypertrophic scar biology.

Adrian Newland MA(Cantab)FRCP FRCPathProfessor of Haematology,Academic Haematology Unit,Pathology GroupAdrian Newland's main researchinterests are in the fields ofImmunohaematology. He haspublished extensively onapoptosis, and has developed theGuidelines and Clinical Studies inImmune Thrombocytopenia. Forthe latter, his department andlaboratory are the main referralcentre in the UK and run theNational Registry, with links inNorth America and Europe. Hisresearch has received extensivegrant support from the LeukaemiaResearch Fund, the Wellcome,Barts and The London CharitableFoundation and industry. Papershave been published in Blood,British Journal of Haematology,Oncogene and Cancer Research.He is also Director of the NorthEast Thames Cancer Network,immediate past President of theRoyal College of Pathologists and Chairs the NICE DiagnosticAssessment Programme.

Dean Nizetic MD PhD Professor of Cellular and Molecular BiologyThe long term research theme ofProfessor Nizetic's group is thestudy of chromosome and genedose effects (aneuploidy and

haploinsufficiency) on cellularfunctions, specifically thephenotypic features of Down’ssyndrome (DS), caused by justone extra copy of perfectlynormal, chromosome 21.Professor Nizetic is one of theworld leading scientists inresearch into DS-associatedleukaemia.

Professor Nizetic's groupparticipated in the generation of aunique mouse model for DS, thefirst mouse to contain the humanchromosome 21. This mousemodel (article in Science in 2005)represented a major scientificbreakthrough in research intoaneuploidies.

Recently, the research group wasthe first to use this system as agenetic dissection tool to pinpointthe single HSA21 generesponsible for the NRSF/RESTde-regulation, the developmentallyearliest disturbance so far seen inDS, in embryonic stem cells (seehttp://news.bbc.co.uk/1/hi/health/7597761.stm).

Edel O’Toole MB PhD FRCPI FRCPDCHProfessor of MolecularDermatologyProfessor O’Toole’s researchfocuses on keratinocyte biology.Research includes signallingmechanisms in squamous cellcarcinoma invasion and survival,the role of type VII collagen inSCC and normal keratinocytebiology, the role of keratins 6a and K16 in keratinocyte cell-celladhesion, and determinants oflocalization of varicella-zosterreplication in skin. ProfessorO’Toole also has an interest in


development of novel treatmentsfor severe skin disease, inparticular, the ichthyoses and skin cancer in severe generalisedepidermolysis bullosa andcollaborates on various geneticsprojects including genetics ofatopic eczema in the Bangladeshipopulation, pachyonychiacongenita, harlequin andsyndromic ichthyoses.

John Oxford BSc PhD Professor of VirologyProfessor Oxford has co-authoredtwo standard texts: Influenza, theViruses and the Disease with SirCharles Stuart-Harris and GCSchild and most recently thefourth edition of Human Virology,a Text for Students of Medicine,Dentistry and Microbiologypublished by Oxford UniversityPress. Professor Oxford has alsopublished 250 scientific papers.His research interest is thepathogenicity of influenza, inparticular the 1918 SpanishInfluenza strain, which hecombines with conducting clinicaltrials using new influenzavaccines and antiviral drugs. Thisresearch has been featured onscience television programmesrecently in the UK, USA, Germanyand Holland. He is ScientificDirector of the college researchvirology company calledRetroscreen Virology Ltdwww.retroscreen.com).

Tanya Parish BSc (Lond) PhD(NIMR)Professor in MycobacteriologyProfessor Parish’s researchfocuses on the important humanpathogen Mycobacteriumtuberculosis, the causative agentof tuberculosis, which is

responsible for the greatestnumber of deaths from bacterialinfections. Her group works onunderstanding the basic biology of the organism in relation to itsability to respond to theenvironment (gene regulation, two component systems, stress

responses), as well as the basicmetabolic pathways required forpathogenesis (isoprenoidbiosynthesis, nitrogen metabolism,cell wall biosynthesis). She is alsointerested in the identification andvalidation of novel drug targetsusing novel genetic methods and

‘‘‘‘

Staff profile: Professor Aine McKnightProfessor of Viral Pathology

Throughout my academic career, Ihave had an interest in HIV/AIDS. In1987, I joined a team at the Instituteof Cancer Research, (London), tostudy the role of neutralisingantibodies to HIV-1 and HIV-2 inpathogenesis. I was awarded anMSc in Immunology, and a PhDboth by the University of London.

“In 2000, I won a fellowship (RCDF)from The Wellcome Trust to developan independent research group tofocus on non-coreceptordeterminants of HIV replication incells at The Wohl Virion Centre,University College London. I amcurrently a Medical Research Council (MRC) Senior Non-clinical Fellow(awarded in 2005).

“The current focus of my research group is mainly on the interfacebetween HIV and the immune system with regard to humoral immunityand a novel innate immune mechanism (Lv-2) that inhibits HIVreplication after cellular entry resulting in abortive infection. The two viralgenes involved in overcoming this antiviral effect have already beenmapped, and we are currently mapping the host gene(s) involved. Otheractive research interests lie in HIV tropism and co-receptor use.

“I am also among a number of scientists taking part in a $25.3 millioninternational research consortium searching for an HIV vaccine. Thegrant is one of the largest awards in a $287 million, five-year programmeof 16 grants provided by the Bill and Melinda Gates Foundation toestablish an international network of HIV vaccine discovery consortia,known as the Collaboration for AIDS Vaccine Discovery.



is involved in the development ofimaging technologies to monitorthe efficacy of drug treatment.Professor Parish is also theDirector of Drug Discovery at theInfectious Disease ResearchInstitute in Seattle. Currentfunding is from the BBSRC, MRC,European Union and the Bill andMelinda Gates' Foundation.

K John Pasi MB ChB PhD FRCPFRCPath FRCPCHProfessor of Haemostasis and ThrombosisProfessor Pasi’s research interestslie in gene therapy forhaemophilia, molecular pathologyof von Willebrands disease, thelink between cancer andthrombosis and the mechanismsof inhibitor development inhaemophilia A.

A gene therapy trial for usingadeno- associated virus for thetransfer of factor IX forhaemophilia B has recently beenapproved in conjunction withcolleagues at University College,London.

Mike Philpott BSc(Wales)DPhil(Oxon)Professor of Cutaneous Biology,Centre Lead for CutaneousResearchProfessor Philpott’s researchinterests lie within two main areasof research within his group. Thefirst is to use the hair follicle as amodel to investigate the role ofgrowth and transcription factors inregulating epithelial-mesenchymalinteractions and the actions ofsteroids. Secondly, they areinterested in understanding themechanisms of sonic hedgehogaction in skin and especially in

relation to development of basalcell carcinoma and stem cell fate.

Raymond Playford PhD(Lond)FRCP(Lond) FRCPath FMedSciProfessor of MedicineRaymond Playford runs agastrointestinal GI Inflammationand Repair Group. Their overallaim is to understand how the gutmaintains itself and rapidly repairsitself following injury.Understanding these processesshould help us understand whysome people go on to get diseasesof the gut and also allow us todevelop new therapeutic options.Research interests include:mechanisms of repair in thegastrointestinal tract; use ofrecombinant peptides to treat orprevent gastrointestinal injury; use of bioactive food products(‘Nutriceuticals’); inflammatoryprocesses in coeliac disease;genetics of coeliac disease andinflammatory bowel disease.

John Priestley BA(Cantab)DPhil(Oxon)Professor of Cell BiologyProfessor Priestley’s researchinterests focus on the anatomyand neurochemistry of dorsal rootganglion (DRG) and spinal cordneurons, with a particular focuson their response to injury and the organisation of pain pathways.Most of this work involvessophisticated techniques forlocalisation of biomolecules intissue sections, together withexperimental studies manipulatingspinal cord and peripheral nervesin vivo. Studies on DRG neurons,have revealed important principlesconcerning their regulation bytarget-derived and injury-derivedgrowth factors. Another major area

of work focuses on spinal cordinjury. Current work includes thedevelopment of biomaterial-basedconduits for peripheral nerve andspinal cord repair, and thedevelopment and evaluation ofnovel neuroprotective agents. Thiswork is funded by Barts and TheLondon Charity, by a spinal injurycharity (ISRT), and by a UK-Chinacollaboration programme (ICUK).

David Rampton DPhil FRCPProfessor of ClinicalGastroenterologyProfessor Rampton's mainresearch activities relate to theinflammatory bowel diseases,ulcerative colitis and Crohn'sdisease. Over the years, he hasstudied various aspects of thepathogenesis of inflammatorybowel disease, and undertakentherapeutic trials of novel agentsaimed at specificpathophysiological targets. Morerecently, he has been in involvedin studies of the use and efficacyof complementary therapies widelyused by patients, and has beeninvestigating the pathogenic role of psychological stress and thepotential therapeutic benefits ofstress reduction in patients withulcerative colitis.

Ian Sanderson BA MA MSc(Oxon)MB BS MD FRCP(Lond) FRCPCHProfessor of PaediatricGastroenterology, Centre Lead for GastroenterologyProfessor Sanderson was the firstto show:

(i) that the enterocyte has distincttransporters on the basolateralaspect for the exit of differentamino acids (published 1980);


Gareth Sanger BSc(N’cle) PhDDSc(Manc) FBPharmacolSProfessor of NeuropharmacologyProfessor Sanger’s laboratory useshuman gastrointestinal tissues,removed as a normal part ofsurgery for gastrointestinaldisorders, to explore humangastrointestinal motility andsecretion by measuring differentneuromuscular and mucosalfunctions in combination withimmunohistochemistry. Theresearch is currently focused intwo main areas. First, thelaboratory is investigatingmechanisms by which hormonessuch as motilin, ghrelin and GLP-1, released from the gut duringfasting or after meals, influencegastro-colonic motility and whendisordered, play roles in obesity,nausea and diarrhoea. Thesecond area of research usessimilar technologies to investigatethe roles of different 5-HTreceptors and other products oftrypotophan metabolism on smalland large bowel neuromuscularfunction, peristalsis and secretion.In both areas, industrialcollaboration means that thelaboratory places its science andits human tissue expertise at theforefront of new medicinedevelopment.

Armine Sefton MB BS MSc MDFRCP(Edin) FRCPathProfessor of Clinical MicrobiologyArmine Margaret Sefton has beenProfessor of Clinical Microbiologyat Barts and The London since2003 and holds an honoraryconsultant contract with thehospital. She is on the SpecialistRegister for both MedicalMicrobiology and Infectious

Diseases. She has a particularinterest in antimicrobialresistance, dangerous pathogensand education / training.

Professor Sefton runs the MSc in Clinical Microbiology whichnormally has around 25 full-timeequivalent students on it. She hasbeen a member of her localMicrobiology Specialty Trainingcommittee since 1996 and was itschair for six years. She is currentlyChair of the Board of Examiners inMicrobiology for the Royal Collegeof Pathologists and sits on theirCollege Advisory Training Team in Microbiology, their SpecialtyAdvisory Committee inMicrobiology, the jointRCP/RCPath Committee onInfection and the joint RCPath /Department of HealthModernising Scientific CareersCommittee. She is also a memberof the National AdvisoryCommittee on DangerousPathogens

Denise Sheer BSc DPhilProfessor of Human GeneticsProfessor Sheer’s research isbased on two inter-relatedthemes: the structure andfunction of human chromosomesand the genetic basis of cancer.Her laboratory is examining theprinciples that govern higher order chromatin architecture and determine its significance forgenome regulation in health anddisease. Current approachesinclude analysis of crucialchromatin modifications duringactivation of the MajorHistocompatibility Complex andduring differentiation of neuralstem cells. The key goals of her

(ii) that enteral feeds are asefficacious in treating childrenwith Crohn's disease as highdose steroids, while showing asignificant benefit for growth(1987);

(iii) that diet can regulate immunegene expression by theepithelium in vivo (1993);

(iv) that short chain fatty acids(SCFA) regulate chemokineand IGF binding proteinexpression in enterocytes through histoneacetylation (1997);

(v) that breast milk contains VEGFin high concentrations, andthat there is a VEGF receptoron the intestinal epithelial cell(1999);

(vi) by epithelial cell-specifictransgenic techniques, thatchemokine expression by theepithelium orchestratesneutrophil and lymphocyteinvasion in vivo (2001);

(vii) that diet and age interact atthe nuclear protein level toregulate gene expression(2004);

(viii) that IL-6 mediates growthretardation in Crohn'sdisease (2005);

(ix) that myofibroblasts enhancechemokine activity of theepithelial cell (2006).

As a clinician he has alsopublished many observations,including being the first todescribe four new diseases ofchildhood, two of which involveinflammation in the GI tract.



cancer research are to expose the critical pathways, providediagnostic and prognosticinformation, and identifymolecular targets for therapy. In the past, her group identifiedcritical genetic aberrations in awide variety of malignancies. They are now conductingcomprehensive genetic andepigenetic studies of braintumours, and recently identifiedactivation of the MAPK pathwayby RAF gene fusions in pilocyticastrocytomas.

Daniel Sifrim MD PhD Professor of GI PhysiologyProfessor Sifrim’s researchinterests are extensive. Recentinvestigations include in vitrostudies on changes in esophagealmucosa permeability due to stressor exposure to bile acids; in vivoanimal studies on pharmacologyof the lower esophageal sphincterand TLESRs; analysis of therelationship between esophagealinflammation and motility; thephysiology of the esophageallongitudinal muscle layer andesophageal shortening;physiological studies in healthyhuman subjects on the role of

inhibitory mechanisms in theregulation of primary andsecondary peristalsis; therelationship between inhibition inthe esophageal body and TLESRs;measurements of tone in theesophageal body; pharmacologicalstudies on TLESRs and reflux;studies in patients with primaryesophageal motor disordersdefining the role of incompleteinhibitory mechanisms in thepathophysiology of diffuse spasmand achalasia; and studies inpatients with GERD characterizingdifferent types of reflux (acid andnon acid) during TLESRs.

Andrew Silver BSc PhDProfessor of Cancer GeneticsProfessor Silver leads theColorectal Cancer Genetics Group.The Group focuses onindividualising treatment andsurveillance protocols for patientswith colorectal cancer (CRC).Current programmes includepredicting outcome to pre- andpost-operative therapy andrecognising which patients withulcerative colitis will develop CRC.Preoperative therapy has a centralrole in rectal cancer treatment,but a sizable

number does not respond. We are developing tests that identifypatients least likely to benefit fromthis therapy. Patients with CRCtreated post-operatively withchemotherapy often have acancer that is partly or completelyresistant. We are analysing CRCsto identify cancers unlikely torespond to find biomarkers thatwill permit more tailored therapy.Patients with longstandingulcerative colitis have anincreased risk of CRC. Throughcollaborations with UC patientsurveillance centres we aredeveloping biomarkers for theearly detection of neoplasticconversion and cancer.

Mary Sugden MA DPhil(Oxon)DSc(Lond)Professor of Cellular BiochemistryProfessor Sugden’s researchstrengths in the regulation ofmammalian metabolism have led to current research projectsrelated to insulin secretion andresistance and associatedmetabolic diseases (eg type 2diabetes and cardiovasculardisease). This research isundertaken in collaboration with


Dr Mark Holness, a Reader in theCentre for Diabetes and MetabolicMedicine. They are currentlyinterested in how insulin secretionis regulated normally and how thepancreatic islet compensates forinsulin resistance induced bychanges in diet or lifestyle,including that associated with latepregnancy, with increased insulinsecretion. They believe that bystudying how mammalian systemsrespond to metabolicperturbations, including thedevelopment of insulin resistance,they may be able to obtain abetter understanding of thefundamental cell biology involvedin cellular adaptation.

David van Heel BM BCh MADPhil MRCPProfessor of GastrointestinalGeneticsProfessor van Heel’s group areresearching the inherited causesof human disease - particularlyintestinal inflammation. Recentsuccesses include identification of new genetic risk factors forcoeliac disease. Many of the riskfactors for coeliac disease overlapwith type 1 diabetes, suggestingstrong similarities between the two conditions. Current researchincludes: identifying furthercoeliac disease risk variants,including structural variants; finemapping existing coeliac diseaseregions to determine causalvariants; understanding how riskvariants influence biologicalfunction; understanding overlapsbetween different autoimmunediseases.

We are major users of the Bartsand The London Genome Centrefor high throughput genotyping,transcriptomics and solexasequencing.

Ping Wang MD(China)PhD(Sweden)Professor of ExperimentalImmunologyProfessor Wang’s researchinterests are in two areas;molecular mechanisms of MHCclass I antigen presentation andantigen-mediated molecularsignalling in T cells. Studies ofMHC class I antigen presentationfocus on the mechanisms forcontrolling the presentability ofantigenic peptides by MHC class Imolecules in antigen presentingcells (APC). His group isinterested in the mechanisms thatretain low-quality MHC class Imolecules in the ER, especiallythe function of tapasin. AlthoughAPC stably present antigen to Tcells, different antigens ordifferent forms of antigenstimulation in a compatibleantigen-presenting environmentcould result in different responsesof antigen specific T cells. Basedon the findings from their basicresearch, the group hasestablished a novel vaccineplatform to develop therapeuticvaccines for melanoma, HIV andHCV.

Norman Williams LRCP(Lond)MRCS(Eng) MB BS(Lond)FRCS(Eng) MS(Lond) FMedSciProfessor of Surgery, Head of Academic Surgical UnitProfessor Williams’ abidinginterest has been theunderstanding of large bowelfunction in health and diseaseand the application of suchknowledge to improve the care of patients, particularly from thesurgical perspective. He hasconcentrated on the feasibility of restoring gastrointestinalcontinuity and normal function inpatients who required anorectalexcision for benign and malignantdisease. He has devised severalnew techniques including aprocedure to replace the analsphincter completely using anelectrically stimulated gracilismuscle and various innovativeinterventions to improve rectalevacuation.

More recently his group hasbecome interested in tissueengineering, and is investigatingthe interaction between porcinecollagen and the human gut witha view to using this inreconstructive colorectal surgery.He has also lead a successful bidto NIHR for the Centre to host oneof only two Healthcare TechnologyCo-operatives designed to bringtogether patients, doctors,scientists and manufacturers todevelop and assess newtechnology and products in thefield of bowel function. Anotherinitiative is to develop a NationalCentre for Bowel Research andSurgical Innovation.


Degree programmesBlizard Institute of Cell and Molecular Science

PostgraduateDiploma inAesthetic SurgeryTwo years part-time – Distance learning

Programme descriptionThe Postgraduate Diploma inAesthetic Surgery is organised by the Centre for CutaneousResearch.

Programme outlineThis programme is designedspecifically to provide a corecurriculum for establishedsurgeons or surgical trainees, who wish to practice in the field of aesthetic surgery followingcompletion of specialist training.

The programme starts in Octoberand runs for two academic years.

The programme consists of amixture of structured distancelearning, DVD/theatre-basedclinical teaching, and adissertation. We cover the entirespectrum of aesthetic surgery with an emphasis on fundamentalprinciples and instruction in awide range of techniques.

Clinical training days will beprovided for up to four days, with video links to theatre and live discussions with the operatingconsultant.

AssessmentA weekly assignment, of which 80 per cent must be successfullycompleted. A dissertation must besubmitted with an examination atthe end of the programme.

Entry requirementsQualification requirements for thecourse are MB BS; MRCS (Part 2)or equivalent. Assessments aremade only of those areas relevantto each specialty based on theirarena of practice.

For language requirements,please see the internationalstudents section on pages 133.

For further information, please see our website at:www.icms.qmul.ac.uk/courses

Further informationSam MatthewTel: +44 (0)20 7882 7173email: [email protected]

PostgraduateDiploma in Burn CareTwo year part-time - Distance learning

Programme descriptionThe Postgraduate Diploma inBurn Care is organised by theCentre for Cutaneous Research.

Programme outlineThe programme is deliveredonline as eight, ten-week modulesover two years. This material issupplemented with DVD materialand limited clinical days (two perannum).

The programme covers:

• The structure and function ofskin, pathophysiology of theburn wound, inhalation injury,the systemic response to burninjury, wound healing andscarring

• Medicolegal and psychiatricaspects of burn practice

• The principles of burnanaesthesia and burn criticalcare within a multidisciplinaryteam environment

• The science and use of dressings and tissue engineered products

• The prehospital, and acute care of burn patients

• Burn reconstruction, scarmanagement, and burnrehabilitation.

AssessmentAssessment is made by weeklyessay or MCQ assignments, and adissertation and exam within thefinal module.

Entry requirementsAn MB BS or equivalent isrequired for entry to the diploma.


Further informationSam MatthewTel: +44(0)20 7882 7173email: [email protected]


PostgraduateDiploma in ClinicalDermatologyOne year part-time - Distance learning

Programme descriptionThere are two separate but linkedprogrammes: one for UK-basedGeneral Practitioners and one fordoctors outside the UK.Successful completion of eitherprogramme leads to award of aPostgraduate Diploma in ClinicalDermatology from the Universityof London.

The programme was extensivelyredesigned in 2009 and combinesclinical expertise with innovativetechnology to facilitate first classtraining in dermatology.

Programme outlineThis programme covers coreaspects of dermatology over a one year period, with particularemphasis on the diagnosis andmanagement of skin disease froma primary care perspective. Thereare 30 weekly modules, producedby experts in the field. Eachmodule comprises written andaudiovisual material and aformative quiz.

Key features - UK programme

• Seven clinical days with clinicalcases, throughout the course ofone year

• Small group consultant-ledteaching

• Weekly interactive web-basedmaterial

• Weekly audiovisual material todemonstrate cases and goodpractice

Key features – Internationalprogramme

• This programme can be studiedanywhere. No travel to the UK isrequired

• Regular small group tutorials,with live chat

• Live interactive lectures

• A discussion forum allows fordiscussion of cases and topicsat your convenience

• Weekly audiovisual material todemonstrate cases and goodpractice

AssessmentStudents are required to write adissertation and to pass a writtenfinal examination. All studentsmust complete at least 80 percent of the weekly formativeassessments during the year.

Please see our webpage for moredetailed programme information:www.londondermatology.org



For informal enquiries, please contactDr Vicky JolliffeProgramme DirectorTel: +44 (0)20 7882 7169email: [email protected]

MSc/PostgraduateDiploma in ClinicalMicrobiologyOne year full-time, two years part-time

Programme descriptionThe programme develops yourskills and understanding inclinical microbiology, and providea thorough knowledge ofassociated subjects (eg molecularbiology). The formal teachingincludes lectures, practicals andworkshops. The lecturers arespecialists in their fields and areinvited from many institutions inthe UK. The practicals areextensive and give you themaximum hands-on experience inall aspects of clinical microbiology.The practicals are taught in alarge purpose-built teachinglaboratory.

Many students use the MSc aspreparation for the MRCPathexaminations and the MSc isaccredited by the Association ofClinical Microbiologists as part ofthe training for clinical scientists.

Programme outlineYour studies are broad-based,with extensive coverage of thefollowing topics:

bacteriology • virology • mycology• parasitology • bacterialpathogenicity • immunology •molecular biology • microbialdisease – diagnosis, treatmentand prevention • antimicrobialsand chemotherapy • epidemiologyand public health • hospitalinfection.


Degree programmesBlizard Institute of Cell and Molecular Science

AssessmentThere are a series of in-courseassessments throughout theprogramme. These assessmentsinclude practical and writtenexaminations, posters, oralpresentations, case reports,essays and comprehension of scientific papers. Eachassessment is designed as alearning experience as well as atest of knowledge. There are fouror five incourse assessments eachyear and they form approximately25 per cent of the end of yearmarks.

The final examinations at the endof year one include a practicalexam and a written paper. Thefinal examinations at the end ofyear two include two writtenpapers, a research project ordissertation and a viva.

Entry requirementsIf you are a medical practitioner,scientist or nurse currentlyworking in the field of infectiousdisease the part-time programmeis most likely to be the best way to study the MSc. Part-timeapplicants must hold anappointment or attachment in a microbiology department of ahospital, HPA or other appropriateinstitution for the duration of theprogramme.

If you are an overseas student ora recent graduate in biomedicalscience you are more likely towant to follow the full-timeprogramme. Graduates in otherrelated disciplines are consideredfor either programme providedthey have suitable experience inmicrobiology.


Further informationPlease contactMichele Branscombe Tel: +44 (0)20 7882 7216email:[email protected]

For informal enquiries, please contactProfessor Armine Sefton Programme DirectorTel: +44 (0)20 7882 8167email: [email protected]

MSc/PostgraduateDiploma inGastroenterologyOne year full-time (MSc) Eight months full-time (PgDip)Distance learning optionavailable

Programme descriptionThe Centre for Digestive Diseasesis one of the largest academicdepartments in the UK andincludes professors in GI genetics,nutrition, paediatrics, surgery,neurogastroenterology, clinicalgastroenterology.


The programme is designed as acurriculum in gastroenterology,hepatology and nutrition for newentrants into these fields and asan update and extension for thosealready in it. The programmeprovides clinicians with theoreticaland clinically applied aspects oftheir discipline with a focus on therelevant basic sciences andresearch techniques.

It is aimed at clinicians wishing to gain strong knowledge of thesciences underpinning the clinicaldiseases and their management.The programme includes the‘taught programme’ from Octoberuntil April and the projects fromApril until submission in August.Those undertaking the Diplomawill complete only the taughtprogramme.

The Centre for Digestive Diseaseshas two endoscopy trainingsimulators and so training inendoscopy on these simulators isprovided throughout the year. Thiswill provide basic skills ofendoscopy and enhances futuretraining in patients.

As a programme based in a largeclinical department there areopportunities to observe clinicalmeetings, audit and occasionalclinics or endoscopy sessions inthe latter part of the programme.

Other opportunities: there arelimited opportunities to stay for amaximum of one year after theMSc for a clinical attachmentwithin the Centre for DigestiveDiseases. Successful completion

of the MSc is required. Additionalfees apply and places are verylimited in numbers. Pleaseindicate on the application form ifyou are interested in continuingwith these opportunities.

For selected high-achievingstudents there are alsoopportunities to stay in the Centreas clinical research fellowsstudying for higher degrees(MD(Res) or PhD).

Programme outlineThe taught programme isorganised into six modules.

Module 1 and 2:The Scientific Basis of GI Diseases

Module 3:Liver and Pancreatic diseases

Module 4:Adult GI Diseases I: Upper GI and IBD

Module 5:Adult GI Diseases II: Lower GI,Neurogastroenterology, Nutrition

Module 6:Paediatric and AdolescentGastroenterology

Assessment1 ‘Taught programme’

• Continuous assessment(including up to six essays)

• Two three hour written exams in April

2 Project

• Written dissertation

• Oral viva

To be awarded the MSc requirespassing both the ‘taughtprogramme’ and the project. To beawarded the Diploma requirespassing the ‘taught programme’alone.

Entry requirementsMinimum requirements forapplications to the programme areMB BS or basic medical degreefrom universities recognised bythe University of London.

For language requirements, pleasesee the international studentssection on page 133.

All students are interviewed by asenior member of the programmebefore being accepted to ensurethey are suitable for theprogramme and the programme is suitable for them.

Further informationNici KingstonTel: +44 (0)20 7882 7191email: [email protected]/courses


Degree programmes – MedicineBlizard Institute of Cell and Molecular Science

PostgraduateCertificate in Non-invasive AestheticTechniquesEight months part-time

Programme descriptionThis intensive programme isdesigned specifically to provide acore curriculum for establishedgeneral practitioners, dentists anddermatologists who wish topractice in the field of aestheticsurgery.

Programme outlineThe programme starts in Januaryand October of each year andruns for eight months.

The programme consists of amixture of structured distancelearning, on line multimedia/ liveclinical teaching, and four essays.We cover the entire spectrum ofnon invasive aesthetic surgerywith an emphasis on fundamentalprinciples and instruction in awide range of techniques.

Two clinical training days will beprovided to demonstrate thepractical applications of the theorystudied in the course material.

AssessmentEach of the teaching packagesincludes bi-weekly multiple choiceexams. A 3,000 word essay mustbe submitted at the end of eachmodule.

Entry requirementsQualification requirements for the course are MB BS/ DDS orequivalent.


For further information, please see:www.icms.qmul.ac.uk/courses


MSc/PostgraduateDiploma/PostgraduateCertificate inTranslationalNeuroscienceOne year full-time

Programme descriptionThe aim of the programme, whichis at present the first of its kind inthe UK and Europe, is to providea thorough training in the mainconcepts and methods oftranslational medicine, with aparticular focus on unmet needsin diseases of the nervous systemand the challenge of developingbetter therapies. At the end oftheir studies students will have adetailed knowledge of the drugdiscovery and developmentprocess, and of clinical trialdesign and methodology and the regulatory environment.

The formal teaching takes placein the Centre for Neuroscienceand Trauma at the BlizardInstitute of Cell and MolecularScience, Barts and The LondonSchool of Medicine and Dentistry,and includes lectures, seminars,clinical workshops and a researchproject. The lecturers arespecialists in their field and are preclinical scientists andclinicians. There are also invitedspeakers, who are leadingresearchers from other UK orinternational academic institutionsand senior scientists from thepharmaceutical industry.

Programme outlineThe programme providescoverage of the following topics:

• Mechanisms of disease anddrug targets in the nervoussystem

• Unmet therapeutic needs in major disease areas inneurology

• Biomarkers of disease and their role in drug development

• Genomics, proteomics,metabolomics, systems biology and bioinformatics

• Drug discovery

• Drug development

• Personalized medicine

• Clinical trial design andregulatory requirements

• Intellectual property

The taught programme starts witha core module which coversfundamental concepts in drug


discovery and development, andcontinues with five specialmodules which covercomprehensively specific diseaseareas. The taught programme isdelivered in two half-days perweek, throughout the academicyear. After the completion of thetaught programme, students carryout a research project, which canbe library-based, laboratory-basedor clinically-based.

AssessmentThe taught modules are assessedusing a combination of finalwritten examinations and in-course assessments. The in-course assessments consist ofliterature reviews, oralpresentations, case analyses andclinical trial protocols. They aredesigned as a learning experienceas well as a test of knowledge.They represent 30 per cent of the module marks. The researchproject assessment is based on awritten dissertation and an oralexamination, which represent 85per cent and 15 per cent of themark, respectively.

Entry requirementsIf you are a recent graduate in medicine, pharmacy orbiomedical science, you are morelikely to want to follow the full-timeMSc programme.

If you are a medical graduate,dentistry graduate, pharmacist ornurse, or scientist in the public orprivate sector, and are currentlyemployed, the PostgraduateCertificate or PostgraduateDiploma may appeal more to you

if you want a shorter programmeof study, more compatible withfull-time professional activity.


Further informationMr Surinder PalTel: +44 (0)20 7882 8605email: [email protected]

For informal academic enquiries,please contact:Dr. Adina Michael-Titus Programme DirectorTel: +44 (0)20 7882 2290email: [email protected]

‘‘‘‘

Cheen Peen Khoo, PhD in AdultStem CellsI am researching the use ofadult stem cells to repair thedamaged pancreas as futuretreatment for diabetes. Mywork primarily focus on the use of stem cells from thebone marrow and blood cells.

I am undertaking my research in the Blizard Building, which houses the BICMS,which is made up of manydifferent departments. Thisclosely knit community allows the exchange of ideas and advice,which is important for my development of my research project.Additionally, the Blizard offers excellent core facilities.

My supervisors are very supportive of my research. They are veryknowledgeable in my field and they have provided me with veryuseful advice which has helped me to develop the direction ofmy current research. Additionally, other staff members fromdifferent departments have been very helpful in giving me advicerelated to their own research fields.

During my time at Queen Mary, I have been accepted to do anoral presentation and two poster presentations. Besides havingthe opportunity to present my results to the scientific community,I have had the opportunity to travel to places that I had not beenbefore, such as Germany and Amsterdam.

Institute of Cancer

39

Institute DirectorProfessor Nick Lemoineemail: [email protected]

Director of Graduate StudiesDr Simon Joelemail: [email protected]

The Institute of Cancer along withthe Centre for Epidemiology,Mathematics, and Statistics hasbeen awarded Cancer ResearchUK Centre status with the aim ofenhancing cancer research in theUK and to train the clinical andnon-clinical research workforce ofthe future.

This new Barts Cancer ResearchUK Centre brings together ourtop-ranked scientists in themedical school with the expertclinical teams in the brand-newCancer Hospital to push forwardlaboratory discoveries into benefitsfor patients. The Centre willparticularly focus on pancreaticcancer, as well as breast, ovarianand prostate cancer, leukaemiaand lymphoma. The laboratoryprogramme explores the genesthat drive cancer, aiming toidentify markers for earlydiagnosis and targets for newtherapies. The Barts Centre is atthe forefront in cancer genetherapy and stem cellapproaches, with a wide-rangingprogramme of clinical trials ofexperimental agents.

The Institute currently representsone of the largest cancer researchbodies in the UK with extensiveinfrastructure investment. Underthe leadership of the Director,Professor Nick Lemoine, theInstitute is at the forefront of bothclinically-based research andbasic science. The spectrum ofresearch spans laboratory studiesin genomics and informatics,through cancer cell biology andtarget discovery, to biomarkerdevelopment and clinical trials of novel therapeutics. At presentaround 30 per cent of theSchool’s research degrees arecancer-related, making theInstitute a cornerstone of theSchool’s research activity.

The concentration of expertiseand state-of-the-art facilitiesprovides an excellent setting forthe delivery of postgraduateteaching and research.

The Institute is committed toproviding its students with acomprehensive set of skills, aninvaluable knowledge base andexposure to the most moderntechnologies, and offers achallenging and innovativelearning environment. Theexperience is designed to furtherunderstanding and enhancecareer prospects in the field ofcancer research.

Overview of researchat the Institute ofCancerOur research strategy is built on an integrated molecular andcellular approach to the problemof cancer in individuals and inpopulations. A spectrum ofresearch is underway andincludes: therapeutic anddiagnostic target identification andvalidation in both haematologicaland solid malignancies; clinicaltrials exploring new therapies; thedevelopment of novel molecularapproaches for diagnosis,classification and treatment of human cancers; andinvestigations into the regulationof tumour spread and host anti-tumour responses. The Institutecurrently has over 300 personnelwithin the following six ResearchCentres:

Centre for Cancer and InflammationCentre lead: Professor FranBalkwillThis centre focuses on the links between cancer andinflammation, in particular the roleof immune cells and mediatorsfound in experimental and humancancers.

Institute of Cancerwww.cancer.qmul.ac.uk

Barts and The London School of Medicine and Dentistry


Institute of Cancer

Centre for Cell SignallingCentre lead: Professor Bart This is a world-class centre of expertise in both basic andapplied PI3K signalling research.The programme focuses on theway in which uncontrolled PI3Ksignalling is one of the mostcommonly deregulated pathwaysin cancer.

Centre for Experimental Cancer MedicineCentre lead: Professor John GribbenThis centre focuses on earlyphase trials of novel therapeuticsdeveloped in the Institute ofCancer, as well as recruitment into late clinical trials, includingNCRN, pharma-sponsored andinvestigator-initiated clinical trialsopen at Barts and The LondonNHS Trust.

Centre for Molecular Oncologyand ImagingCentre lead: Professor Nicholas LemoineThis is an internationallyrecognised centre of expertise ingene therapy for cancer, with anactive programme of clinical trials,as well as programmes for theidentification of molecularbiomarkers of disease progressionand treatment response. It housesthe state-of-the-art molecularimaging facilities for bothpreclinical and clinical studies.

Centre for Medical OncologyCentre lead: Professor AndrewListerThis centre has a long anddistinguished history in haemato-oncology, urological andpaediatric malignancies, havingled several pivotal trials in thetreatment of these cancers.

Centre for Tumour BiologyCentre lead: Professor Ian HartThis centre is concerned primarilywith understanding the role thatcytoadhesion plays in modulatingcancer spread and has focusedparticularly on the involvement ofmembers of the integrin family ofadhesion receptors.

More information on our researchstrategy and staff researchinterests can be found at:www.cancer.qmul.ac.uk


Senior staff research interestsInstitute of Cancer

Norbert Avril Dr med Dr medhabil MDReader, Nuclear Medicine, Centre for Molecular Oncologyand ImagingDr Avril works on the use ofmolecular imaging with positronemission tomography (PET) fornon-invasive monitoring ofchemotherapy and gene therapyto define (early) markers oftreatment response in clinicaltrials.

Fran Balkwill PhD FMedSciProfessor of Cancer Biology,Centre Lead, Centre for Cancerand InflammationProfessor Balkwill’s research aims to understand links betweencancer and inflammation,especially the role of inflammatorycytokines and chemokines andtranslate this information intonovel clinical trials.

Subham Basu PhDHonorary lecturer, Centre forMolecular Oncology and ImagingDr Basu’s research interestsinclude understanding signaltransduction pathways responsiblefor both tumourogenesis and theresistance of tumour cells tocytotoxic and other apoptoticagents, as well as theidentification and characterisationof the protein substrates of theserine/threonine kinase Akt, animportant regulator of severalcellular processes frequentlyderegulated in cancer.

Dan Berney MA MB B ChirFRCPathSenior Clinical Lecturer, Centre forExperimental Cancer MedicineDr Berney’s research focus is inprostate, penile and testicularcancers, using tissue micro-arrayto create high throughput arraysto examine numerous biomarkers.

Claude Chelala PhDLecturer, Centre for MolecularOncology and ImagingDr Chelala’s current researchwork focuses on the developmentand application of computationalsolutions to cancer research.

Finbarr Cotter PhDProfessor of ExperimentalHaematology, Centre for MedicalOncologyProfessor Cotter’s researchinterests include functionalgenomics and proteomics for B-cell malignancies (in particularindolent lymphoproliferationincluding Chronic LymphocyticLeukaemia (CLL) and FollicularLymphoma), myelodysplasia andmolecular therapy.

Tatjana Crnogorac-Jurcevic MD PhDSenior Lecturer, Centre forMolecular Oncology and ImagingDr Crnogorac-Jurcevic is workingon the development of abiomarker programme inpancreatic cancer, with specialemphasis on searching for novelindicators of early disease. She is concerned with the functionalanalyses of markers expressedearly in the development ofpancreatic adenocarcinoma.

Pedro Cutillas PhDLecturer, Centre for Cell SignallingDr Cutillas is using a range ofsystem biology approaches toquantify cell signalling pathways.Taking leukaemia cells as aparadigm, the aim is to provideinsights into the mechanism ofoncogenic signalling and howthese contribute to the onset andprogression of cancer.

Jude Fitzgibbon BA(Genetics)PhDSenior Lecturer, Centre for Medical OncologyDr Fitzgibbon works on thedissection of the molecular eventsleading to the development andprogression of lymphoma andleukaemia by studying bothfamilial and sporadic cases.

John Gribben MD DSc FRCPFRCPath FMedSciProfessor Centre Lead, Centre forExperimental Cancer MedicineProfessor Gribben leads studieson immunological responses toleukaemia and lymphoma. Theaim is to implementimmunological treatments,including allogeneictransplantation, to improve the outcome for patients withhaematological cancers.

Richard Grose BSc PhDLecturer, Centre for Tumour BiologyDr Grose uses geneticallymodified mouse models and cellculture approaches to delineatethe functions of Fgfs and theirreceptors in epithelial repair andcarcinogenesis.


Thorsten Hagemann MD PhDSenior Clinical Lecturer, Centre for Cancer and InflammationDr Hagemann’s research groupaims to understand thefundamental mechanisms by which cancer associatedinflammation promotes tumourprogression in pancreatic cancer;with particular reference to therole of macrophages and theirphenotype in carcinogenesis.

Gunnel Halldén PhDSenior Lecturer, Centre forMolecular Oncology and ImagingDr Halldén's research interestsinclude the development of novelreplication-selective oncolyticadenoviral mutants targetingprostate and pancreatic cancers.Her focus is the identification ofcellular mechanisms involved inthe selective cancer cell killingand the synergistic effects of virusand chemotherapy combinations.

Ian Hart BVSc PhD FRCP FRCPathMRCVS FMedSciDeputy Director Centre Lead,Centre for Tumour BiologyProfessor Hart focuses on integrinexpression and function in tumourinvasion and progression;regulation of tumour spreadspecifically by cell adhesionreceptors and their associatedmolecules as expressed at thetumour cell surface.

Kairbaan Hodivala-Dilke PhDSenior Lecturer, Centre forTumour BiologyHodivala-Dilke using integrin-deficient mice to investigate the functions of integrins in

pathological angiogenesis andwound healing, exploiting theavb3-integrin-null endothelial cells to understand better themechanism by which avb3-integrin regulates growth factorreceptors. She is investigating the identification of differentiallyregulated angiogenesis relatedmolecules as novel candidates for anti angiogenesis therapy.

Helen Hurst MA PhDProfessor of Transcription Biology,Centre for Tumour BiologyProfessor Hurst focuses onunderstanding the role of the AP-2 family of transcription factors inthe pathogenesis and response totreatment of breast cancer,understanding the gene targets ofAP-2 factors in breast cancer andthe regulatory mechanismsinvolved in their expression. Inparallel she is working on definingthe hallmarks of anti-hormonerefractory breast cancer in patientsamples and exploring links withAP-2 positive disease.

Li Jia PhD MDSenior Lecturer, Centre for Medical OncologyDr Jia’s research interests are cellular and molecularmechanisms of cell death andapplication in the treatment ofhuman leukaemia. Her currentwork focuses on understandingthe regulation of Bcl-2 family ofproteins (Bax) by proteasome andimplication in the prognosis ofchronic lymphocytic leukaemia(CLL) and developing novel anti-cancer compounds based onnutural occurring peptide.

Simon Joel BSc FIMLS PhDSenior Lecturer, Centre forExperimental Cancer MedicineDr Joel’s research focuses on theinvestigation and development ofnovel therapies and optimisationof the use of established agents,mainly in haematologicalmalignancies. He also works on the development of modelsystems for evaluating newtherapeutic agents, using celllines, primary culture assays,tumour xenografts and primarytumour material.

Louise Jones MB ChB PhDFRCPathProfessor Breast Cancer, Centre for Tumour BiologyProfessor Jones leadsinvestigations in breast cancer of mechanisms that promoteprogression of in-situ to invasivedisease with the aims ofidentifying markers which canpredict behaviour, and noveltherapeutic targets. He focuses on the analysis of the functionalsignificance of phenotypicchanges identified in ductalcarcinoma in situ in order toidentify markers that may predictdisease progression, and noveltherapeutic targets.

Stephanie Kermorgant PhDLecturer, Centre for TumourBiologyDr Kermorgant works onfurthering the understanding of the temporal and spatialregulation of tyrosine kinasereceptor, c-Met, signalling thatlead to metastasis by theemerging concept of ‘endocytic



signalling’. She is concerned withevaluating how c-Metinternalisation and subsequentsignalling events regulate tumourcell migration and invasion.

Hemant Kocher MB BS MS MDFRCSClinical Senior Lecturer ClinicianScientist, Centre for TumourBiology Dr Kocher leads studies onpancreatic cancer progressionwith special reference to thestromal reaction in pancreaticcancer. He researches thedevelopment of in vitro models of pancreatic cancer, andinvestigation of pancreatic stellate cells.

Toby Lawrence BSc PhDSenior Lecturer, Centre for Cancer and InflammationDr Lawrence undertakes studieson the cell biology of inflammationand particularly endogenous anti-inflammatory mechanisms toreveal insights into mechanisms of chronic inflammation. He isparticularly interested in theinvestigation of the tissue specificrole for IKK‚ in inflammation andimmunity.

Nick Lemoine MD PhD FRCPathFMedSciInstitute Director Centre Lead,Centre for Molecular Oncologyand ImagingProfessor Lemoine’s researchinterests include targetidentification and validation in studies on the molecularpathology of pancreatic cancerand target exploitation throughviral and genetic therapies.

Andrew Lister BA MA MD FRCPFRCPath FRCR FMedSciCentre Lead, Centre for MedicalOncologyProfessor Lister’s research groupfocuses on the pathogenesis andtherapy of haematologicalmalignancies. The aim is toimprove the prognosis of germinalcentre-derived lymphoma andacute myeloid leukaemia throughrational design of clinical trialsdemonstration of prognosticfactors that will allow informedrisk taking in selection of therapy;and identification of newtherapeutic targets particularly in relation to the mechanism oftransform of follicular lymphomato large B cell lymphoma.

Yong Jie Lu MD PhDSenior Lecturer, Centre forMolecular Oncology and ImagingDr Lu’s research interests includeidentification of regions of thegenome of significance in thedevelopment, progression andtreatment of male urogenitaltumours and identification of thegenes from these regions likely tobe involved. He is involved instudies of genetic alteration asuseful markers of tumourbehaviour and potential targets for novel therapies.

John Marshall PhDSenior Lecturer (Hon), Centre for Tumour BiologyDr Marshall undertakes studies of the biology of the epithelial-specific integrin, avb6 in cancer.He focuses on the development ofavb6-antagonists for imaging andtherapy, with the aim of

developing novel targetingapproaches to avb6-expressingcarcinomas.

Stephen Mather BPharmFRPharmS MSc(Biopharmacy)PhDDeputy Centre Lead, Centre forMolecular Oncology and ImagingProfessor Mather is concernedwith the development ofradiolabelled peptides andantibodies for diagnosis andtherapy of cancer in clinical and pre-clinical research.

Iain McNeish MA PhD MRCPMRC Senior Clinical FellowDeputy Director Centre forExperimental Cancer Medicine,Centre for Molecular OncologyProfessor McNeish works onutilising abnormalities in thecontrol and execution of apoptosisin ovarian carcinoma cells aspotential targets for viral andgenetic therapy. He is involved in establishing an early phaseclinical trial programme ofselectively replicatingadenoviruses in women withrecurrent ovarian carcinoma.

Silvia Montoto MB BS MD Clinical Senior Lecturer, Centre for Medical OncologyDr Montoto focuses on naturalhistory and prognostic factors ofpatients with follicular lymphoma(FL), specifically, the analysis ofthe risk factors and prognosis ofhistological transformation in FLpatients,as well as the clinicalimpact of the diagnosis of Fl inpatients with diffuse large celllymphoma (DLCL).

Heather Oakervee BSc MB BSMRCP MRCPath Clinical Senior Lecturer, Centre forExperimental Cancer MedicineDr Oakervee runs clinical trials in haematological malignancies,multiple myeloma and has beeninvolved in many clinical trials ofthe new agents recentlyintroduced in myeloma andoptimising their use. Her mainwork now comprises early phaseclinical trials, in particular inmyeloma and also in trialmanagement.

Daniel Oberg Lecturer, Centre for MolecularOncology and ImagingDr Oberg’s research is on in vivo imaging and eradication oftumours using cancer-targetedviruses armed with genes for:visualisation of viral oncolyticactivity, local conversion of pro-drugs into cytotoxic metabolitesand induction of anticancerimmune responses.

Bijendra Patel MS FRCSFRCSGen Surg)Clinical Senior Lecturer, Teaching CentreMr Patel's main academic interestis in virtual reality surgicalsimulation as a tool for theacquisition and retention ofsurgical technical skills. As aclinical senior lecturer he hasestablished the MSc in SurgicalSkills and Sciences, the UK's firstMasters course for surgicaltraining by simulation.

Tom Powles MB BS MD MRCPClinical Senior Lecturer, Centre forExperimental Cancer MedicineDr Powles research focuses oncomparing sequential cancertissue (or cancer cells isolatedfrom the blood) before and aftersunitinib therapy.

David Prowes BSc PhDSenior Lecturer, Centre forMolecular Oncology and ImagingDr Prowes’ research aims tounderstand and target themolecular events involved in thedevelopment and progression ofprostate and penile cancer.

Manoj Raghavan MA MB BS PhDMRCP FRCPathClinical Senior Lecturer, Centre for Medical OncologyDr Raghavan’s research continuesto analyse genomic changes inthe DNA of relapsed AML, usingmicroarray technologies that cover the whole genome andinvestigates whether their low-level presence at diagnosis canpredict who may relapse.

Rodney Reznek MB ChB MRCPDMRD(Diploma in MedicalRadiodiagnosis) FRCR FRCP Professor of Diagnostic Imaging,Centre for Molecular Oncologyand ImagingProfessor Reznek’s work focuseson the use of magnetic resonanceimaging and computer topographyin the diagnosis, prognosis andtreatment of cancer, particularlygynaecological, abdominal, andendocrine cancer.



Ama Rohatiner MD FRCPProfessor of Haemato-Oncology,Centre for Medical OncologyProfessor Rohatine’s interest is in the development of curativetreatment for haematologicalmalignancy, with special emphasison diffuse large B-cell lymphomaand follicular lymphoma.

Rebecca Roylance BSc MB BSMRCP PhD Clinical Senior Lecturer, Centre forMolecular Oncology and ImagingDr Roylance’s research interestsinclude the identification of genesinvolved in low grade breastcancer and elucidation ofpathways of progression in breasttumorigenesis.

Peter Szlosarek BSc MRCP PhDClinical Senior Lecturer, Centre forMedical Oncology and ImagingDr Szlosarek’s group is exploringwhy argininosuccinate synthetase(ASS), a rate-limiting enzyme in L-arginine synthesis, is aberrantlyexpressed in human cancers.

David Taussig BSc MB BS MRCPFRCPath PhD Clinical Senior Lecturer, Centre for Medical OncologyDr Taussig’s interests includeelucidation of the mechanism bywhich acute myeloid leukaemia(AML) induces bone marrowfailure and the study of leukaemiastem cells.


Bart Vanhaesebroeck PhD Centre Lead, Centre for CancerCell SignallingProfessor Vanhaesebroek workson understanding the biologicalfunctions and signallingmechanisms of the class IAphosphoinositide 3-kinases(PI3Ks), implicated in the controlof various cellular processes suchas growth, proliferation, survival,differentiation and cell migration.He also uses genetically modifiedmice in which the genes for theseenzymes are inactivated touncover the functions of theindividual PI3K isoforms inembryology, immunologicalsignalling, and in regulation of theactin cytoskeleton as it regulatescell migration.

Yaohe Wang MD PhDSenior Lecturer, Centre forMolecular Oncology and ImagingDr Wang’s research focuses onthe development of replication-selective oncolytic viruses forcancer therapy, examining themodulation of the innate immuneresponse to enhance theantitumour potency of oncolyticadenovirus, and identification ofgenetic events in tumour cells thataffect the life cycle of adenovirus.He is working on the developmentof a new generation of oncolyticadenovirus and vaccinia virus withincreased potency and reducedtoxicity based on dissection of thefunction of viral genes

Bryan Young BSc PhDProfessor Molecular Oncology,Centre for Medical OncologyProfessor Young is involved in

studies on the pattern andsignificance of uniparental disomyand microdeletions in leukaemiausing high density SNP arrays. Healso works on the integration of

large genome-based data sets todevelop a functional view of theleukaemia genome. Acute myeloidleukaemia is the main modelused.

Staff profile: Professor Bart VanhaesebroeckCentre Lead, Cell Signalling

‘‘‘‘

I studied at the University of Ghent, Belgium, gaining aMasters degree (1985) inBiology (Physiology andBiochemistry) and a PhD(1990) in Molecular Biology.My PhD work focused onimmunology and signaltransduction by cytokines.

I joined the Institute of Cancerto set up the Centre for Cell Signalling, a group with a focus on understandingsignalling through PI 3-kinases(PI3Ks), combiningfundamental research withefforts to translate findings into diagnostic and therapeuticapplications.

Our team proposed the now universally acceptedclassification andnomenclature of the PI3KsPhilosophical Transactions ofthe Royal Society of London1996:351:217, TiBS1997:22:267).

Other team activity includespioneering the use of so-called'kinase knockin' mice in whichthe active site carries a

mutation in an ATP-bindingamino acid residue, leading to inactivation of the kinase.These provide a moreadequate physiological modelfor the effects of smallmolecule kinase inhibitorsthan classical gene knockoutapproaches (Cell2004:118:274; TiBS2005:30:194).

Partly through these researchefforts, p110delta has becomea drug target in cancer,inflammation and auto-immunity. These discoverieswere successfully incorporatedinto the drug developmentprogramme of Piramed, and isnow being further developedby Roche.

In addition to being a memberof EMBO (European MolecularBiology Organisation), I haveworked as a consultant forSerono (Geneva), PIramed,AstaZeneca and Intellikine.


Degree programmesInstitute of Cancer

MSc in CancerTherapeuticsOne year full-time, two years part-timeDistance learning optionavailable

Programme descriptionThis programme aims to provideyou with a clear understanding ofthe scientific basis underlying theprinciples and practice of cancer

therapeutics and thedevelopment, evaluation andimplementation of newtreatments. This is underpinnedby a thorough knowledge ofcancer biology and pathology,research methodologies, drugdevelopment and regulatoryissues. There is an emphasis onpractical skills during the researchskills module and the three monthlaboratory project undertakenduring semester three.

On completion of the programmeyou will:

• Have a thorough knowledge ofthe principles underlying cancertreatment

• Be able to demonstrate skills ingathering, recording, analysingand presenting information

• Understand the regulatoryframework underlying clinicalresearch

• Understand the principles of laboratory methodologiesapplied to clinical trials

• Understand the steps involvedin developing and implementingnew treatments

• Be able to apply this knowledgein a professional role

• Be able to contribute to theresearch activity and knowledgebase in improving cancer care.

Programme outlineCore modules: Research Skillsand Sciences • Cancer Biology •Cancer Pharmacology • SiteSpecific Tumour Treatment •Ablative Therapy • BiologicalTherapies • Drug Development •Lab Project

Optional modules: Imaging •Pathology of Cancer • GenomicApproaches to Human Diseases •Paediatric and AdolescentOncology • Cancer Preventionand Screening

‘‘‘‘Sarit Badiani, MSc in SurgicalSkills and Sciences

With a background in surgicaltraining, I was interested inundertaking a Mastersprogramme where I couldacquire both research andpractical skills. Having lookedextensively at the various MSccourses available I believe thiswas the only availableprogramme to cover both theseaspects.

This MSc is unique in the way it provides an opportunity to be part of, as well as undertake academic research, along with the practicalskills training involving the use of endoscopic and laparoscopicsurgical simulators. There has always been a high level of supportfrom all members of the department which makes studying here avery positive experience. I would strongly recommended this MSc for anyone wishing to pursue any surgical career.

I was aware of Queen Mary's high reputation, and the work carriedout at the Institute of Cancer in particular. I was excited to be part of such a highly recognised institution. Overall, I think the facilitiesassociated with the University are of an extremely high standard.There is a real opportunity to be part of something special.

I am keen squash player so I try and keep on top of my game.Squash is great physical exercise, and I’ll always enjoy it.


Assessment Assessment will be based onwritten assignments, poster andoral presentations, written or MCQexaminations, and a full labproject write-up.

Entry requirementsThe programme is open tograduate scientists, nurses,clinicians and other medicalprofessionals working inhealthcare, the pharmaceuticalindustry or contract researchorganisations. Entry to theprogramme will require a degree,or degree equivalent qualification,from a recognised academicinstitution or an appropriateprofessional qualification orexperience.

For language requirements,please see the internationalstudents section on pages XX.

Distance learning optionThis programme is also availableas a distance learning option andis delivered via our web basedlearning system known asblackboard. You will be able tofollow each lecture online viaaudio recordings andslide/whiteboard content. Allwritten assignments are submittedthrough the Blackboard systemand poster and oral presentationsassessed through SKPE/webcamsystem. You are encouraged tointeract with teaching staff andother students in onlinediscussion forums and join groupactivities and be part of theInstitute’s student community.

Further informationGeneral programme enquiries:Tel: +44 (0)20 7882 2081email: [email protected]

For informal enquiries pleasecontact:Dr Simon JoelProgramme Directoremail: [email protected]

MSc in MolecularPathology andGenomicsOne year full-time, two yearspart-timeDistance learning optionavailable

Programme descriptionThis programme combines coreteaching of disease mechanismsand molecular technologies, withan emphasis on the developmentof critical and practical skills. Itwill provide you with the essentialknowledge and skills to pursue aresearch career, either in a clinicalor scientific setting, andcontribute to the growing need for scientists and clinicians topromote the translation ofmolecular advances into theclinical situation.

On completion of the programmeyou will:

• Demonstrate a coreunderstanding of humanpathology and molecular biology

• Have an in-depth knowledge ofthe principles and applications

of molecular technologies asapplied to human disease

• Be proficient in experimentaldesign, bioinformatics, datamining and interpretation

• Demonstrate skills in oral andwritten presentation and incritical review of the literature

• Contribute to the researchprocess through experience of a laboratory project placement

• Understand the ethicalframework of the researchprocess

• An emphasis on development ofpractical skills is reflected in theResearch Skills Module, and thethree month laboratory-basedproject.

Programme outlineCore modules: Basic MolecularBiology • Basic Pathology •Cancer Prevention and Screening• Genomic Approaches to HumanDiseases • Molecular Diagnosticsand Therapeutics • MolecularPathology of Solid Tumours •Research Skills and Sciences •Lab project

Module options: BiologicalTherapies • Introduction to Bio-Informatics • Molecular Geneticsof Haematologic Malignancies

AssessmentAssessment will be based onwritten assignments, poster andoral presentations, written or MCQ examinations, and a fulldissertation write-up.



Entry requirementsThe programme will be open toclinicians, graduate scientists,nurses, and other medicalprofessionals working in a clinical,industrial or academic researchenvironment. Entry to theprogramme will require a gooddegree, or degree equivalent,qualification from a recognisedacademic institution or anappropriate professionalqualification or experience.

For language requirements,please see the internationalstudents section on page 133.

Further informationGeneral enquiriesTel: +44 (0)20 7882 2081email: [email protected]

For informal enquiries, please contactProfessor Louise JonesProgramme Directoremail: [email protected]

MSc/PostgraduateDiploma inOperativeGynaecology andMinimally InvasiveSkillsOne year full-time, two yearspart-time

Programme descriptionThis unique programme offersstudents a highly advancedtheoretical and practical

understanding of OperativeGynaecology and MinimallyInvasive Skills. Using innovativesimulation technology, the aim of this programme is to providesurgeons in training with a year of instruction to develop operativesurgical skills.

This course provides ‘hands-on’practical training to helpaccelerate the surgical trainingand improve surgical skills thatare essential for buildingconfidence and competence intrainees and thus maximise thetraining opportunity in NHS.

On completion you will be able to:

• perform basic laparoscopytasks.

• perform laparoscopic suturing

• perform laparoscopicprocedures (Salpingostomy,Salpingectomy, Tubal ligationand Oophorectomy)

• perform specific open surgicalskills

• understand the tools andmethodologies for conductingresearch.

For suitably able students, thecourse will provide an excellentfoundation for MS/MD orMPhil/PhD studies and obtaininggrants, in open competition, fromthe work carried out in theirdissertation.This uniqueprogramme offers the opportunityto develop or extend expertise inthe established and rapidlydeveloping areas of Laparoscopic

Surgery and GastrointestinalEndoscopy.

Programme outlineCore modules: Practical SkillsAssessments by simulation andcertification by the course tutor •Written examination: A final theoryexam consisting of short andessay questions • ContinuousAssessments: essay writing,critical appraisals andpresentations • Dissertationproject write-up and presentation

AssessmentYou will be assessed in thefollowing ways: practical skillsassessments by simulation andcertification by the course tutor •written exam: a final theory examconsisting of short and essayquestions • continuousassessments: essay writing,critical appraisals andpresentations • dissertationproject write-up and presentation.

Entry requirementsThis programme is aimed at trainees in Obstetrics inGynaecology and specialistregistrars, non-carrier gradeSurgeons, associate specialists. A medical degree from arecognised institution is requiredand some postgraduateexperience in surgery is desirable.

The programme does not involveany direct contact with thepatients so GMC registration is not required for overseas doctors.



Further informationGeneral enquiriesTel: +44 (0)20 7882 3847email:[email protected]

For informal enquiries pleasecontact:Bijen PatelProgramme Directoremail: [email protected]

MSc/PostgraduateDiploma inOperativeOrthopaedics andArthroscopy SkillsOne year full-time, two yearspart-time

Programme descriptionThe aim of this programme is toprovide surgeons in training with a year of instruction to developoperative surgical skills inorthopaedics using state-of-the-artsimulation technology.

With the modernisation of medicaleducation resulting in a decreasedperiod of surgical trainingcombined with the new EU timedirective, trainees must acquiretechnical skills within a shorterperiod of time. This programmewill help you accelerate thesurgical training and improvesurgical skills that are essential for building confidence and

competence in trainees and thusmaximise the training opportunityin NHS.

On completion you will be able to:

• perform specific core skills in orthopaedics surgery

• perform basic diagnosticarthroscopy for knee andshoulder

• perform arthroscopic procedure

• perform Practical specific opensurgical skills techniques

• understand basic researchmethods and submission of a dissertation.

For successful students, theprogramme will provide anexcellent foundation for MS/MD orMPhil/PhD studies and obtaining

grants, in open competition, fromthe work carried out in theirdissertation. This wouldencourage more doctors tobecome clinical scientists.

Programme outlineCore modules: Core Skills inOperative Orthopaedic Surgery •Open Surgery Skills • ArthroscopyProcedural Skills • Upper LimbArthroscopy Skills • Lower LimbArthroscopy Skills • ResearchMethods • Dissertation

AssessmentYou will be assessed in thefollowing ways: practical skillsassessments by simulation andcertification by the course tutor •written exam: a final theory examconsisting of short and essayquestions • continuous

Graduate profile: Linsey Madadi

Studied:MSc Cancer Therapeutics – graduated 2007

Currently:Studying for a PhD in the CancerPharmacology lab within the Institute of Cancer, Barts and TheLondon School of Medicine and Dentistry at Queen Mary.

Why did you choose Queen Mary?The Cancer Therapeutics programme most closely matched what Iwas looking for, combined with the great facilities and location ofQueen Mary.

What are your career plans in the next five years?To finish my PhD and then either return to my previous role as aclinical oncology and haematology pharmacist, or continue myresearch in academia or the pharmaceutical industry.



assessments: essay writing,critical appraisals andpresentations • dissertationproject write-up and presentation.

Entry requirementsThis programme is aimed atsurgeons in training, trainee andspecialist registrars, non-carriergrade Surgeons, associatespecialists. A medical degree froma recognised institution is requiredand some postgraduateexperience in surgery is desirable.





MSc in SurgicalSkills and SciencesOne year full-time, two years part-time

Programme descriptionThis unique programme offers theopportunity to develop or extend

expertise in the established andrapidly developing areas ofLaparoscopic Surgery andGastrointestinal Endoscopy.

The MSc accelerates surgicaltraining and improves surgicalskills that are essential forbuilding confidence in clinical

practice. The programme willprovide you with a uniqueopportunity to gain postgraduatetraining and development incognitive and motor skills usingthe surgical simulators.

‘‘‘‘

Dr Georgios KallisMSc degree in Surgical Skillsand Sciences

The continuous development ofcurrent surgical techniques aswell as the constant stream ofrevolutionary advancements inthe surgical field sparked myinterest to further broaden mylearning in and experience of

surgical techniques. However, I did not wish to embark on either a general course or a very classroom-orientated one. The MSc inSurgical Skills and Sciences offered by Queen Mary is unique inoffering exclusive surgical skills through interactive learning andtraining at the state-of-the-art Virtual Reality Surgical SimulationCentre in a low-stress, high-feedback environment.

I very much enjoy learning and training at the state-of-the-art VirtualReality Surgical Simulation Centre which provides me with theopportunity to enhance and develop a broad range of skillsincluding my laparoscopic and endoscopic skills in a risk-free andcontrolled environment.

I would rate the MSc course in Surgical Skills and Sciences veryhighly in terms of teaching excellence and academic facilities. Inaddition to the surgical skills training, the weekly journal clubpresentations have allowed me not only to develop a higher level of scientific appreciation but also to learn how to critically appraiseresearch papers and perform literature reviews. The focusedsyllabus and scope of the course has enabled me to advance thecompetencies relevant to my chosen specialty of surgery, both froma surgical perspective and the development of other necessaryskills such as academic writing, presentation techniques andorganisational/time management abilities.


The state-of-the-art Virtual RealitySurgical Simulation Centreremoves the patient from theequation to allow novice learningand skill mastery to occur in alow-stress, high-feedbackenvironment while protecting the patient from proceduralinexperience.

You will also be taught techniquesof secure suturing, knot tying andbowel anastomosis using nonbiological materials.

This programme will also provideyou with a clear understanding ofthe concept and theoriessurrounding the issues ofresearch and critical appraisalalong with academic writing.

This surgical skills gained on thisprogramme aims to enhance yourfuture career prospects inSurgery. If you perform well andexpress an interest you may begiven the opportunity to proceedto MD(Res) or PhD studies.

Programme outlineThe programme comprises of thefollowing surgical skills areas anda research/literature project:

Core modules: BasicLaparoscopic Skills • AdvancedLaparoscopic Skills • LaparoscopyProcedural Skills (LaparoscopicCholecystectomy) • BasicEndoscopy skills • EndoscopyProcedural skills (FlexibleSigmoidoscopy) • EndoscopyProcedural skills II (Upper GIEndoscopy) • Research Methods• Dissertation

AssessmentPractical Skills Assessments bysimulation and certification by the course tutor • Written exam: a final theory exam consisting ofshort and essay questions •Continuous Assessments: essaywriting, critical appraisals andpresentations • Dissertationproject write-up and presentation

Entry requirementsThis programme is aimed atsurgeons in training, trainee andspecialist registrars, non-carriergrade Surgeons, associatespecialists. A medical degree froma recognised institution is requiredand some postgraduateexperience in surgery is desirable.





Institute of Dentistry


Institute of Dentistrywww.smd.qmul.ac.uk/dental

Institute DirectorProfessor Farida Fortuneemail: [email protected]

Director of Graduate StudiesProfessor Wagner Marcenesemail: [email protected]

Barts and The London is aninternational leader in oral anddental sciences. In the 2008Research Assessment Exercise,the school was ranked 1st in theUK for 4* and 3* outputs and2nd in the UK overall, accordingto the Times Higher Education.Combining a strong tradition ofclinical, epidemiological andpublic health research and a soldresearch base, Barts and TheLondon is at the forefront of theadvancement of dental care.Cutting-edge laboratories and firstclass facilities enable the work ofthese research teams and clinicaltrials to be carried out to thehighest ethical and governancestandards.

The Dental School of The LondonHospital Medical College wasformed in 1911 and moved intothe current Dental Institutebuilding in 1965. Barts and TheLondon School of Medicine andDentistry was formed in 1995 and merged with Queen Mary,University of London in the sameyear. The School shares the visionof Queen Mary that learning takesplace in a research environmentthat enriches the teachingprocess. It also acknowledges its location in east London andembraces the potential this offersfor teaching and learning. The

Institute of Dentistry offers afriendly, focused and successfulenvironment for postgraduatestudy.

Since 1996 the Institute ofDentistry’s external income hasexceeded £5 million. Over 80 percent of our full-time staff publishon a regular basis in prestigiouspeer-reviewed internationaljournals. Overall responsibility forthe research degree programme is delegated to the Director ofGraduate Studies, currentlyProfessor Wagner Marcenes, butday-to-day responsibility rests withthe research student’s supervisor.Our policy is that our dentalresearch should always be in the main stream of BiomedicalResearch, contributing to it and at the same time benefiting fromstrong interdisciplinary links.Research students are normallyinitially registered for an MPhildegree and are required to attenda taught course in their first year.On successfully presenting theirfirst year’s research to anacademic from outside the DentalSchool, they are transferred to thePhD.

Postgraduate resourcesThe well established Centre forOral Biometrics, comprising thefifth and sixth floors of theInstitute of Dentistry, provides afocus for clinical postgraduateactivity, offering seminar space,office, computing and clinicalfacilities. It includes a DentalMetrology Unit equipped withfacial laser scan and facial imageanalysis. Microbiology and Cell

and Molecular Biology resourcesare based in the award winningBlizard Building, which is one ofthe multidisciplinary researchfacilities housing over 300Biomedical Scientists. Coreresearch facilities within theSchool of Medicine and Dentistryalso include a new GenomicsCentre development for highthroughput DNA sequencing,genotyping and realtime PCR; anew Functional Genomics facilitycontaining robotics andmicroarray readers; and a newImaging Centre containingconfocal and electron microscopy.Biophysics and Biomaterials arebased in modern, well-equippedlaboratories on the Mile Endcampus, adjacent to relevantcollaborators in the Department of Chemistry and Department ofMaterials Science at Queen Mary.In addition, the Institute ofDentistry is located in east Londonand serves the largest multi-cultural population with highsocio-economic diversity in theUK. This provides a uniqueopportunity to carry out populationbased studies and inferconclusions to nearly allenvironments.

You can find details of staffmembers, their research interests,publications and contact detailson the Institute of Dentistrywebsite:www.smd.qmul.ac.uk/dental


Institute of Dentistry

You will also find titles of theseswritten by current researchstudents, as well as links to othersources of information within theCollege at:www.smd.qmul.ac.uk/postgraduate/index.html)

Research degreesThe Institute of Dentistry has along tradition of high quality andoriginal research. There are about40 academic members of staffactively pursuing researchprogrammes, about half beingbasic scientists. We currently have about 56 research students.Within the Institute, researchinterests cover many areasincluding physics, chemistry,materials science, anatomy,biochemistry, physiology,bacteriology, cell and molecularbiology, pathology andepidemiology, in addition to thevarious specialisms of clinicaldentistry, for exampleorthodontics, prosthetics,geriodontics, periodontology, oralmaxillofacial surgery, paediatricand conservative dentistry. Weencourage joint supervision ofresearch students betweendisciplines, including members of the main Medical School andwider College. Entry requirementsare a good science or clinicaldegree appropriate to theresearch to be undertaken.Research students may start atany time with the agreement oftheir supervisor.

For information about applying fora research degree please contact:

Professor Wagner MarcenesDirector of Graduate StudiesTel: +44 (0)20 7377 7632 Fax: +44 (0)20 7377 7064 email: [email protected]

Research areasResearch in the Institute ofDentistry is organised withinmultidisciplinary research groupswhich provide critical mass ofexpertise, common interests and a fulfilling academic environment.Major areas of research are:Infection and Immunity, Lead: DrRobert Allaker, Oral Cancer, Lead:Professor Ken Parkinson, PhysicalSciences in Dentistry, Lead:Professor Robert Hill and Clinicaland Population Research, Lead:

Professor Wagner Marcenes).Research interests within thesegroups include the following:

Infection and immunity• Microbial pathogenesis and virulence

• Microbial-host interactions and immune defences

• Naturally occurring antibacterialpeptides and other molecules

• Mucosal immune responses

• Clinical studies and geneticfactors in oral ulceration

• Host bacterial reactions in periodontal diseases.

• Cell biology of bone formationand tissue regeneration

• Risk and prognostic factors in Periodontitis.


Oral cancer• Oral epithelial ageing and role of telomerase in oral cancer

• Epithelial stem cells in cancer

• Keratinocyte biology

• Biology of tumour invasion and role of integrins.

• Clinical studies of treatments in oral cancer

• Behavioural factors andsmoking cessation.

Physical sciences in dentistry• Physical chemistry of dentalcaries

• X-ray microtomography of dental hard tissues

• Crystallographic studies ofenamel and biomaterials

• Changes in bone structureassociated with ageing andtooth loss

• Salivary proteins in enamelhomeostasis and dental caries

• Biomechanical properties ofbone and dental hard tissues

• Polymer chemistry and dentalmaterials

• Development of polymers for drug delivery devices

Clinical and population research• Clinical and population studieson socio-psychological,economic, and behaviouraldeterminants of oral healthinequalities

• Clinical and population studieson tobacco cessation in the oralhealth environment

• Clinical and population studieson oral health impact on qualityof life

• Population studies on theburden of oral diseases

• Clinical studies on determinantsof treatment outcomes of oraland dental conditions, includingoral cancer, Behçets Syndrome,Dry mouth, Periodontaldiseases, and malloclusion

• Clinical studies on minimumintervention

• Development of primary carenetworks for practice basedresearch

• Systematic reviews(collaborative work with theCochrane Oral Heath Group)

Rob Allaker BSc PhD(UWE) FHEAReader in MucocutaneousMicrobiologyDr Allaker’s research interestsfocus on microbial-hostinteractions in the oral cavity andtheir relationship to local andsystemic disease. The role ofantimicrobial peptides and NitricOxide in non-specific immunity iscurrently under investigation. Heholds research awards from the StBartholomew’s and the RoyalLondon Charitable Foundation.His publications includeAdrenomedullin and mucosaldefence: interaction between hostand microorganism, as well asnumerous papers on skin and oralmicrobiology. He currentlysupervises research students onthe following topics: The use ofplant extracts in oral hygiene andAdrenomedullin and mucosaldefence in the oral cavity.

Paul Anderson BSc(Leeds)PhD(Lond) MInstP CPhysReader in Biophysics in Relation to DentistryDr Anderson’s main researchinterests are model systems fordental caries; salivary proteins in enamel homeostasis; X-raymicroscopy; and diffusionprocesses in porous solids. Hiscurrent publications focus ondemineralisation in enamel andhydroxyapatite aggregates atincreasing ionic strength; GR3DX-ray microscopic study of theextent of variations in enameldensity in first permanent molarswith idiopathic enamelhypomineralisation; boneformation in polymeric scaffolds

evaluated by proton magneticresonance microscopy and X-raymicrotomography; and X-raymicrotomographic study ofmineral concentration distributionin deciduous enamel.

Lesley Bergmeier CBiol MSBFHEA PhD(Lond)Senior Lecturer in AppliedMucosal Immunology (nonclinical)Dr Bergmeier’s research focuseson mucosal immunology. Herbackground has been in thedevelopment of mucosal vaccinein particular the development ofvaccine strategies against HIV.This work has expanded toinclude investigation of innate and cognate responses to noveladjuvants (heat shock proteins -HSPs) in relation to viral proteinsand the HIV co-receptor CCR5.Recent projects included theinduction of immune responses to peptide bound to human heatshock protein as a vaccinestrategy against HIV infection.Investigation of theimmunomodulatory properties ofHSPs has also involved studies oftheir involvement in Behçets andCrohn’s Diseases, both of whichhave significant oralmanifestations. The main focus of the current research is tounderstand the oral proteome inthe context of oral manifestationsof health and disease.

Ray Croucher BSc MA PhD(Lond)ILTMProfessor of Community OralHealth, Associate Dean for DentalPostgraduate Taught ProgrammesProfessor Croucher’s researchcareer has focused on psycho-social risk factors for oraldiseases. Initially he worked in dental health educationprogrammes for adolescents andthe young child. Current interestsare multidisciplinary studies ofstress as a risk factor forperiodontal disease, the role oftobacco use in oral and systemicdiseases, the potential role of thedental workforce in tobaccocessation and the development of alternative models of servicedelivery for underservedpopulations. He manages atobacco cessation programme for east London’s Bangladeshicommunity. Professor Croucherhas published widely on thesetopics. He is the joint author ofAchieving Oral Health, recentlytranslated into Japanese, and acollaborator in the newlypublished text Dental PublicHealth: a primer.

Alan Cruchley PhD(Lond)Senior Lecturer in Oral PathologyDr Cruchley’s research activity isprimarily concerned with thedefensive and protective capacityof oral mucosa. More recently, thishas expanded into exploring therole of permeability barrier indisease; drug delivery within theoral cavity; mechanisms involvedin oral permeability barrier repair;the role of saliva derived growthfactors in oral mucosa; and the


Senior staff research interestsInstitute of Dentistry


response of the oral mucosa toexternal challenge. This hasincluded exploring the effect ofaetiologic agents associated withthe development of oral disease(mercury; paan extracts) as wellthe effect of oral health productsand dental materials.

Elizabeth Davenport BDS PhDMSc(Lond) FDS RCS ILTMProfessor of Dental EducationProfessor Davenport’s researchinterests focus on the delivery ofeducation in the dental setting.This research has resulted in thedevelopment of a Progress FileLearning System for use byundergraduate dental students,supported by funding from theGovernment Office for London. An Electronic Progress File for thedental education continuum is inongoing development. Shereceived the IADR EducationResearch Group Travel Award for work completed in this area.Professor Davenport also retainsan interest in the investigation ofthe relationship of maternalperiodontal disease and thedelivery of pre-term and low birth weight infants.

Graham Davis BSc (Eng) PhD(Lond)Reader in 3D X-ray imaging.Dr Davis’s background is inelectronic engineering and hisprimary research interest is thedevelopment and application of X-ray microtomography (XMT). Hehas developed a unique XMTscanning facility here that isoptimised for obtaining highquality 3D images for mapping

and quantifying mineralconcentration in biological hardtissue. His scanners have alsobeen used in a variety of otherfields and he currently holds anEPSRC grant to develop a newsystem sensitive enough to resolveink in rolled parchment (a team ofcomputing engineers at CardiffUniversity are working on softwareto take these images and virtuallyunroll them). The ultimate is to beable to read historical scrolls thatare too damaged to unroll. At thesame time, this will also providethe next generation scanner forcontinuation of hard tissueresearch.

Stephanie Dowker BSc(Nott) PhDBDS(Lond) CChem MRSC Senior Lecturer in ConservativeDentistryDr Dowker’s main researchinterests focus onphysicochemical mechanisms ofde- and remineralisation in dentaltissues and synthetic analogues,the chemistry and crystallographyof apatitic calcium phosphates,and x-ray absorption methods forquantitative imaging. Her researchis supported by the MRC, EPSRC,St Bartholomew’s and The RoyalLondon Charitable Foundation, aswell as industry.

Farida Fortune CBE BDS MB BSMRCP PhD FRCP FDSRCS FRSAand DipEdT (Med and Dent)Dean of Dentistry, Director of theInstitute of Dentistry, Professor ofMedicine in Relation to OralHealthProfessor Fortune is the Directorfor the Institute of Dentistry and

Centre Lead for the Centre forClinical and Diagnostic OralSciences (CDOS) which includesoral biology, oral microbiology, oralpathology, oral medicine, oralsurgery and oral and maxillofacialradiology. Her research focuseson the role of inflammation andimmune related mucosaldiseases. She is especiallyinterested in the influence ofgenetic profile on inflammatorymucosal disease; themicroenvironment changes andthe genetic basis of oro-facialCrohn's Disease; the influence of inflammatory status on woundhealing and the prognosis and theregulation of healing in normal,fibrotic and ulcerative lesionsaffecting the oral mucosa. TheCentre has established a majorresearch group in head and neckcancer. She is also involved ineducational and research supportprojects in HIV/AIDS as well assupporting African researchers. In addition she has contributedwidely both to undergraduate andpostgraduate dental and medicaleducation, especially thespeciality of human disease.

Mark Hector BSc BDS PhD(Lond)Professor of Oral Health ofChildrenProfessor Hector’s researchcentres on the physiologicalcontrol of oral function,specifically how salivary calciuminteracts with salivary proteins toprevent demineralisation andpromote remineralisation ofdeciduous and permanentenamel; the physico-chemicalaspects of dentine and tooth



sensitivity; and the developmentand validation of a numericalmodel of food comminution. Inthis research he collaborates withcolleagues both within andoutside Queen Mary.

Robert Hill BSc MsC PhD(Lond)DICProfessor of Physical Sciences in Relation to DentistryProfessor Hill’s research centreson degradable glasses, bioactiveglasses, restorative dental fillings,glass (Ionomer) cements, glass-ceramics, demineralisation,remineralisation phenomena andcaries, toothpastes, mode ofaction of strontium and fluorideon hard tissues. He is currentlyworking on new biodegradablecements for use as adegradablebone glue. He is the UKrepresentative of technicalcommittee four of theInternational Congress of Glassthat deals with glasses for medicalapplications and the UKrepresentative on TechnicalCommittee seven that deals withnucleation and crystallisation ofglass.

Ama Johal BDS MSc PhD FDSRCSMOrthRCS FDS(Orth) RCSSenior Clinical LecturerDr Johal’s principle researchareas include sleep-relatedbreathing disorders and quality-of-life issues. He has publishedwidely and both his clinical andresearch work has been rewardedby numerous national prizes andan international prize. He is sub-editor of the European Journal ofOrthodontics and is academic

lead in Orthodontics, which hasrecently established a PhDprogramme.

Ginny Kingsmill BDS PhD(Lond)FDSRCSSenior Lecturer in RestorativeDentistryDr Kingsmill’s main researchinterest centres around the bonechanges that occur in the jawsfollowing tooth loss, and theeffects of osteoporosis. In someindividuals the bone loss is soexcessive that it is difficult toprovide any satisfactory form oftooth replacement (eg dentureswith or without implants). Shecurrently holds a research awardfrom the Department of Health.She has published several paperson this topic and has given talksboth nationally and internationallyon the subject.

Helen Liversidge B Ch D MScPhD(Lond)Senior Clinical LecturerDr Liversidge’s research centreson the worldwide variation in thetiming of permanent toothformation; application of dentalmaturity standards to estimateage; third molar development andestimating age of majority. Shehas collaborated with researchersin South Africa, East Africa, WestAfrica, Italy, Middle East,Malaysia, Brazil, Japan, Australia,New Zealand. She is an associateresearcher in the Human Originssection of the Natural HistoryMuseum, London. Her researchhas international importance inthe field of forensic dentistry andanthropology.

Ian McKay BA Dphil(Oxon)LecturerDr McKay is part of the groupinvestigating the risk factors forthe development of periodontaldisease. Current work focuses onthe relationship between geneticpolymorphisms and the levels ofproteins including interleukin-1aand matrix metalloproteinases inthe gingival tissues. The aim is toidentify genetic risk factors for thedevelopment of periodontaldisease and understand howtheses may act at the cellularlevel. Other ongoing researchincludes the analysis of thecellular activity of novel bioactiveceramic materials and especiallythe role played by silicon inmineralisation of bones and teeth.Dr McKay’s work has resulted inthe recent award of a grant fromthe NIHR.

Wagner Marcenes BDSMSc(Brasil) PhD(Lond)Professor of Oral EpidemiologyProfessor Marcenes' researchprogramme has concentrated onestablishing a new paradigm tofurther elucidate oral healthinequalities from the socialenvironment, throughpsychosocial factors, exploringbehavioural and biologicalpathways to oral health. The mainfocus is on socio-psychologicalprotective (internal and externalresources) and risk factors(stress), and their interaction withupstream (ie: environment) anddownstream (ie: behaviour)factors. His innovative researchadopted the life course approachto elucidating the occurrence of


‘‘

‘‘Staff profile:Wagner Marcenes BDS MSc PhDProfessor of Oral Epidemiologys

I enjoy teaching at the Schoolof Medicine and Dentistry. Theinnovative curriculum is basedon Problem Based Learning,which makes teaching astimulating experience. Myteaching is informed by thebelief that it is more effective to provide students with achallenge to allow them todevelop reasoning skills andmake rational judgments,avoiding giving them the "right"solution to a problem. Studentsenjoy this approach and theteaching sessions areintellectually stimulating.

The School of Medicine andDentistry’s strong researchculture offers a supportiveinfrastructure and theopportunity for multi-disciplinary researchcollaboration. Its location ineast London provides anexciting research environmentfor population studies becauseit resembles the modern multi-cultural and complex society,and presents the medical andsocial challenges of we need toaddress in the new millennium.

The opportunity to develop pre-eminent multi-disciplinarycollaborative research projectsat Queen Mary has contributed

greatly to my researchon explaining oralhealth inequalities fromthe social environment,through psychosocialfactors, exploringbehavioural andbiological pathways to oral health.

My researchprogramme hasconcentrated onestablishing a newparadigm to elucidateoral health inequalitiesfrom the socialenvironment, throughpsychosocial factors, exploringbehavioural and biologicalpathways to oral health. In aseminal study we demonstratedthat oral health is related towork stress (risk factor) andmarital quality (protectivefactor).

This work provided a solidreputation and foundation forseveral collective works thatdemonstrated the harmfuleffects to oral health ofexperiencing unfavourablesocio-psychologicalcircumstances (ie negative life events, daily hassles) and socio-psychological status (personal relationshipdifficulties, risk-takingbehaviour), belonging to lowsocio-economic groups, andliving in socially and materiallydeprived areas. Also, we

showed the protective effect of schooling, favourable socio-psychological circumstances(positive life-events,social/family support) andsocio-psychological status(Sense of coherence, locus ofcontrol, pro-social behaviour).Furthermore, we demonstratedthe plausibility of theserelationships through abehavioural pathway (Oralhygiene, diet, smoking, dentalattendance). Our next step is to test the interactive effect ofupstream (Socio andpsychological environment)and downstream (Biomedicalfactors) determinants of oraldiseases, and demonstrate abiological pathway to furtherexplain the relationshipbetween environmental factorsand oral health.



oral diseases and the outcome oftreatment. His paper “Doespsychological stress mediatesocial inequalities in tooth loss?”published in 2008 was awardedthe prestigious IADR prize forBest Clinical Research in 2009.Professor Marcenes has carriedout several clinical trials andpopulation studies to demonstratethe burden of oral diseases in theUK and abroad, which includesimpact of oral health status onpeople’s quality of life. Currentlyhe is leading the oral health groupof experts carrying out the GlobalBurden of Diseases studyhttp://www.globalburden.org/.

Valeria Marinho MSc PhD(UCL)Senior Lecturer in BioinfomaticsDr Marinho joined the Centre forAdult Oral Health in April 2005.Previously she worked at theDepartment of Epidemiology andPublic Health (UCL), and for boththe Cochrane NeuromuscularDisease Group at Guy's, King'sand St Thomas' School ofMedicine (King's College London)and the Oral Health SpecialistLibrary (National Library forHealth – NHS). As part of herPhD, and under the aegis of theCochrane Oral Health Group, shehas conducted a series ofsystematic reviews on topicalfluorides for caries prevention, of impact on national andinternational level/practice. Hermain research interests are inevidence synthesis, andsystematic reviews methodology,with particular applications indental health, public health, and

evidence based health care. DrMarinho is an editor of theCochrane Oral Health Group, amember of the Cochrane RevManAdvisory Group (CochraneInformation Management SystemGroup), and Chair of the selectionpanel for The CochraneCollaboration Aubrey SheihamPublic Health and Primary CareScholarship.

Ken Parkinson BSc PhD(Glas)Professor of Head and NeckCancerProfessor Parkinson’s researchinterests are focused onmechanisms of human oralepithelial cell ageing and howthese mechanisms break downand lead to oral neoplasia. Themechanism of oral epithelialageing is unknown but mayinvolve the reduction of repeatsequences at the chromosomeends (telomeres) due toinsufficient telomerase and/or theaccumulation of the cell cycleinhibitor p16INK4A. The ability to understand and manipulateepithelial replicative lifespan mayhave therapeutic benefit in a widerange of human diseases,including cancer and ageing.Professor Parkinson is a memberof the European TelomeraseConsortium and currently holdsgrants from the EuropeanCommunity and CR UK.

Mangala Patel BSc MScPhD(Lond) Senior Lecturer in DentalMaterialsDr Patel’s research activity isprimarily concerned with the

development of novel polymericmaterials for use in clinicaldentistry and orthopaedics, basedon the fundamental principles ofpolymer science. In orthopaedicsher work has resulted in a boneand cartilage repair material.Biocompatible, low shrinkagemethacrylate based systems,involving detailed studies ofphysico-mechanical propertieshave also been developed. Otherwork includes the generalevaluation of proprietary dentalmaterials. Further researchcentres on developing novelpolymeric drug delivery systems(biomaterials) for the transport of therapeutic (active) species,locally within the oral cavity and in the body, including detailedstudies of the kinetics of waterabsorption and release of activeagents. Dr Patel was awarded anESPRC grant for her work onformulating a self disinfectingalginate impression material.

Sharanbir K Sidhu BDS MScPhD(Lond) MFDSRCS FADM FICDClinical Senior Lecturer/HonoraryConsultant in Restorative DentistryDr Sidhu’s main researchactivities are in dental materials,adhesion as well as interfaceswith hard tissues, and she is aleading authority on glass-ionomermaterials. She has publishedextensively and presentedinternationally. Other areas of research include dentineperfusion, laser preparation of teeth, and interest in dentalmaterials and the biologicalinterface as well as cariology. Shehas previously been awarded a


prestigious international researchaward, the 2001 IADR ToshioNakao Fellowship, from theInternational Association forDental Research and has been on funded research sabbaticalsworking under eminent authoritiesin the USA and Japan. She hasalso been a member of theEditorial Board of one ofdentistry’s most highly-rankedjournals, the Journal of DentalResearch, for two terms since2001 and is a member of acommittee at the InternationalAssociation for Dental Research.

Anwar Tappuni LDS RCS,PhD(Lond), MRACDS (OM), FHEAClinical Senior Lecturer in OralMedicineAnwar Tappuni is the AcademicLead for Oral Medicine. She isresponsible for the managementof the undergraduate andpostgraduate subjectprogrammes. Dr Tappuni is amember of the Royal College ofSurgeons Examination Board forDiploma in Special Care Dentistryand Chair of the BDA RefugeeDentists Stakeholder Forum. Shehas a special interest in the oralmanifestations of HIV/AIDS and isa member of the InternationalScientific Committee for OralHealth and Disease in AIDS. Herresearch focus is on the causeand effect relationship in oraldisease. Currently she is involvedin research projects on dry mouthand Behçets disease. Dr Tappunihas developed a subjectivemethod for assessing and scoringthe severity of ulcerative disease.She has supervised and published

research projects on thedevelopment of a novel methodfor examining and diagnosing skinand oral vascular lesions and atechnique for the assessment ofthe swelling of the lips in patientswith oro-facial granulomatosis.She is on the BDA Roll ofDistinction for outstanding serviceto UK dentistry.

Ahmad Waseem BSc MSc MPhilPhD (AMU, Aligarh, India)Reader in Oral BiologyDr Waseem’s research interestfocuses around the mechanismsidentifying molecular markers ofhead and neck cancer that canbe used in the diagnosis of thedisease, which can then beemployed in clinical settings. Hisaim is to decipher the molecularpathways that are altered in oralcancer and this knowledge will beemployed to identify the molecularperturbations in the disease,which will lead to thedevelopment of novel treatment

modalities. Dr Waseem is amember of the Editorial Board of the International Journal ofDentistry.

Hong Wan BSc MScPhD(Liverpool)Non Clinical Senior Lecturer in Molecular ImmunobiologyDr Wan originally was trained indentistry and moved to researchafter having obtained her PhD inthe Department of ClinicalEngineering, Faculty of Medicine,University of Liverpool in 1995.Her research focuses ondesmosome junctions in normalepithelia and diseases,particularly, in recent years, onthe novel role of the desmosomalcadherin, desmoglein 3 (Dsg3), in the regulation of cell-celladhesion, cell proliferation,differentiation and morphogenesisand also on its modulation indiseases such as oral cancer andpemphigus. This study has beenmade possible after her

‘‘‘‘Staff profile:Dr Muy-Teck TehLecturer in Head and NeckCancer

My research interests arefocused on finding newbiomarker genes for predictingearly oral cancer formation.

Currently studies are based around a known cancer gene calledFOXM1B using human oral keratinocytes cells as the researchmodel. Early results have showed that FOXM1B may be an earlycancer marker which is expressed at a higher level in pre-cancerand cancer cells compared to normal cells. The future aim is todevelop a diagnostic test using the Gene Chip technology that canguide treatment strategy.



successful cloning of human Dsg3a few years ago. Currently, DrWan together with her team aretrying to characterise this novelfunction of Dsg3, which willprovide new insight into thebroader functions of this gene in epithelial cell biology that isexpected to have importantimplication for our understandingthe pathogenesis of variousdiseases including pemphigusand cancer.

Robert Whiley BSc(Leeds)PhD(Lond) Cbiol MBiolSenior Lecturer in OralMicrobiologyDr Whiley’s main researchinterests focus on the diversity of the commensal flora of themouth, particularly the oralstreptococci, and the diseaseassociations of opportunisticpathogens. This work has beenfunded by the MRC and TheLondon Hospital Special Trustees.Current studies include the role of a human-specific cytotoxinproduced by Streptococcus

intermedius, a resident of dentalplaque that is associated withserious abscesses at non-oralsites. Long-term collaborationsexist with colleagues from QueenMary and Japan. He haspublished widely on describingnew species of streptococci andwill be contributing the chapter onthe genus Streptococcus for theforthcoming second edition ofBergey’s Manual of SystematicBacteriology. Dr Whiley is a co-applicant on a recently awardedEPSRC grant which aims todevelop a fully functional, self-disinfecting dental alginateimpression material.

Ferranti Wong BDS MScPhD(Lond) FDSRCSEdFDSRCS(Eng) Professor of Paediatric DentistryProfessor Wong's main researchinterest is cariology and themanagement of caries in children.He is a main collaborator of amulticentre clinical trial toinvestigate a new biologicalapproach in treating caries in

children. Professor Wong'sbroader interests include dentaltrauma, dental anomalies anddevelopment of dental materials.

Paul Wright BDS PhD(Lond)FDSRCSProfessor of Prosthetic Dentistry,Honorary Consultant inRestorative DentistryProfessor Wright’s researchinterests are firmly based inremovable prosthodontics with astrong bias to clinical research. A continual thread of interest inmasticatory function has led himinto biomaterial research with adefined interest in using soft liningmaterials and implant-stabilisedprostheses. The opportunitiesoffered by implant stabilisedprostheses have enabled work on the effects of the occlusion on masticatory function and theeffects of prostheses on thesupporting tissues, especiallybone. Current work includes thedevelopment and validation of anumerical model of foodcomminution and the effects offood surrogates on the long-termdurability of soft lining materials.


PostgraduateDiploma in DentalClinical SciencesOne year full-time

Programme descriptionThis programme offers dentalgraduates a comprehensivegrounding in five key trainingareas: basic sciences and theirapplication to modern day dentalpractice, principles of clinicalissues in dentistry, principles ofcommunication skills, principlesof professionalism and principlesof management and leadership.This programme aims torecognise previous professionalexperience and to augment anddevelop that experience.

Two pathways are available. Bothprovide strong foundations forcontinuing postgraduate study.Students wishing to undertake theMembership of the Joint DentalFaculties professionalexaminations (MJDF) arerecommended to apply for thecore pathway. The enhancedpathway is recommended forthose students seeking bothMembership of the Joint DentalFaculties professionalexaminations (MJDF) and theoverseas Registration Examination(ORE) or possible progression to aclinical MSc or MClinDentprogramme.

Programme outlineThe syllabus is taught throughlectures, seminars, tutorials andsymposia. Communication and IT

skills are developed throughweekly journal club reports andpresentations on dental andclinical governance topics.Students will be tutored inObjective Structured ClinicalExaminations (OSCE) andStructured Clinical Reasoning(SCR) exams using the facilities in the newly equipped state-of-the-art Dental skills laboratory

All students will observe currentUK dental practice via clinics inOral Medicine, Oral andMaxillofacial Surgery,Periodontology, Paediatricdentistry, Orthodontics, Sedationand General Anaesthesia. Theywill practice taking radiographsusing phantom heads. Theenhanced pathway offers studentsgreater emphasis on clinical skillsdevelopment, using phantomhead and teeth.

Students will prepare andcontinuously update aProfessional DevelopmentPortfolio for gathering evidence on lectures, tutorials, clinics, selfstudy and self reflection sessions.Upon completion of theprogramme, students will attaincertificates in core skills, requiredfor continuing professionaldevelopment (CPD).

AssessmentStudents are continuouslyassessed through written multiple-choice papers in single-bestanswer (SBA) and extendedmatching questions (EMQ) format.The final examination will includetwo written papers, an OSCE and

SCR exam. An audit project andclinical case presentation will alsoform part of the final programmeassessment.

Entry requirementsApplicants should have arecognised degree in Dentistryfrom an approved University and12 months post qualificationexperience.


Further informationDr Eleni Hagi-PavliTel: +44 (0)20 7882 7141email: [email protected]

or

Ryan Salucideenemail: [email protected]

MSc in DentalPublic HealthOne year full-time, two yearspart-time

Programme description For dentists and other graduateswishing to pursue a career indental public health, oralepidemiology and healthpromotion in a service oruniversity setting, this programmeoffers supervised experience inthe theory and practice of dentalpublic health and the opportunityto develop specialist knowledgeand skills. It can contribute to athree year specialist trainingprogramme in Dental PublicHealth. Completion offers

Degree programmesInstitute of Dentistry


Degree programmes Institute of Dentistry

eligibility to enter the Diploma inDental Public Health examinationof the Royal College of Surgeons(England).

Programme outline Your programme includestimetabled seminars, personalstudy and supervised research. All taught modules are consideredcore modules, although you haveconsiderable choice whenselecting a research topic. Thetaught modules’ content includes:

• Oral health needs and demandsassessment, including criticallyevaluating the dental literature,preparing scientific reports,familiarity with indices anddeterminants of oral disease,epidemiological principles andinformation sources

• Information technology,including computer skills in data analysis, analysingepidemiological data andcompetencies in commoncomputer software packages

• Service planning and evaluation,including resource allocation,measuring service quality andconducting audits

• Promoting oral health, includingthe principles, methods andlimitations of prevention andoral health promotion, healthdeterminants and preventivestrategies

• Research methodologies, bothsocial science and clinical, andthe application of scientificprinciples to research.

Students are encouraged todevelop appropriate key written,oral, group work and timemanagement skills.

Assessment You are assessed on a modularbasis. The assessmentprocedures vary between eachmodule and include writtenpapers, in which three questionswill be answered from a choice,long essays, drafting studyprotocols, proposing a solution tooral health needs and a criticalreview of a published paper usingappropriate criteria. One third ofyour final grade is through yourcompletion of a 20,000 wordproject report. You will also takepart in an oral examination basedon your project report.

Entry requirementsWe acknowledge professionalpractice gained from a widevariety of relevant backgrounds,requiring a minimum of two year’spost qualification full-timeexperience in addition to having a recognised degree.


Further informationProfessor Ray CroucherTel: +44 (0)20 7882 8662email: [email protected]

MSc/PostgraduateDiploma in DentalTechnologyOne year full-time, two yearspart-time

Programme description As a future leader/technician inthe field of Dental Technology youwill be better prepared to advanceyour knowledge through researchand training, and to strengthenlinks with clinical members of thedental team. This is an importantstep in the future education andmanagement of otherprofessionals working in areascomplementary to dentistry. Thisprogramme is carried out in theSchool of Medicine and Dentistryand involves both technicalpractice and academic study. Youwill be a dentist or basic scientistwho may be responsible for theteaching of related subjects, oryou may need a greaterunderstanding of the subject inorder to plan your future industrialor academic/research careers.

Programme outlineThis programme includestechnical training, formal teachingand a supervised researchproject. All the taught andtechnical modules in theprogramme are core modules.You will be able to select the topicof your research project from yourarea of interest.


The programme comprises eightmodules and technical practice,covering Statistics, Ethics andResearch Methods, the Propertiesof Dental Materials, Occlusion, anIntroduction to Implantology,Aesthetics, Technical Practice and a Project Report.

AssessmentIf you are following the one-yearfull-time programme you will beexamined on your coursework inJune. This will be through twowritten papers, together with anoral examination on a submittedtechnical case. The PostgraduateDiploma can be awarded at thispoint. Your accumulated markswill go towards the final MScaward for which you should alsosubmit a project report by theSeptember of the year that youcomplete the programme.

Entry requirementsApplicants should possess arecognised qualification in DentalTechnology through assessments,including a written examination ofa standard comparable to a three-year Foundation Degree in DentalTechnology or a GraduateCertificate in Dental Technology(SMD) awarded at the level ofmerit. A minimum of two yearspost-initial qualificationexperience, and the ability todemonstrate advanced Technicalexpertise in the field, is required.Applicants may also be requiredto satisfy a practical trade testprescribed by the programmelead before admission.

Other applicants require a degree(minimum of second classhonours) in a subject relevant toDentistry, such as basic sciencesor medical/bioengineering, or theequivalent in professionalqualifications and experience.


Further informationDr Mike CattellTel: +44 (0)20 7377 7000 ext 2160email: [email protected]

GraduateCertificate inDental TechnologyFour months full-time

Programme descriptionThis programme is designed tohelp future leaders/technicians in the field of Dental Technology,without a degree, to build on theirqualifications and to improve theirskills and knowledge beforeconsidering entry to Masters leveleducation. The on-campusGraduate Certificate programme is conducted over four months atlevel 6. Successful completion ofthe Certificate will allow studentsto progress to the Diploma/MSc in Dental Technology. This

‘‘‘‘

Jonathan Collier, PhD inDentistry

I researched the role ofchemokine receptors in oralcancer metastasis. Oral cancer is a devastating disease and thisstudy focused on a possiblemechanism by which thesetumours spread around thebody.

There is an enormous amountoffered by the College withregards to facilities and furtherdevelopment. As a clinician itwas important to be close to amajor teaching hospital. The facilities are first class and there is ahuge diversity of departments within the College that really facilitatescollaborative research. If you are stuck and don’t know how to tacklesomething then there is a wealth of resources (academic andpractical) available to help you.

I was proud to be able to present my work in competitions at thenational and then the international conferences for dental research. The latter was in Brisbane, Australia – and the bonus was I won!



programme is also available toapplicants with a dental/sciencequalification who may beresponsible for teaching of relatedsubjects.

Programme outlineThis programme includes formalteaching, technical practice and asupervised project. All the taughtmodules in the programme arecore modules. You will be able toselect project topics according toyour area of interest.

The programme comprises four modules:

• Basic Science I

• Basic Science II

• Technical practice

• Project.

AssessmentStudents will be expected to complete 12 essays ascoursework assessments whichwill constitute 40 per cent of thetotal marks for the GraduateCertificate. At the end of Modulefour, students will be examined bytwo written papers on the subjectscovered. A project report and oralexamination will also be expected.A reflective practice log book willbe kept for the technical work.

Entry requirementsApplicants should possess theappropriate broad-based training,experience and knowledge forentry. This might be measured bypossession of a recognised Dental

Technology qualification (seebelow), a minimum of two yearspost-initial qualificationexperience, and the ability todemonstrate advanced technicalexpertise in the field. Applicantsmay be required to satisfy apractical trade test.

A recognised qualification inDental Technology throughassessments, including a writtenexamination of a standardcomparable to the Higher NationalCertificate in Dental Technology orthe Dental Technicians AdvancedCertificate of City and Guilds ofLondon Institute.

A minimum IELTS score of 6.5 (or an equivalent alternativequalification) is also required foroverseas students where Englishis not the first language.


Students will be required tocomplete the Graduate Certificateto progress to the PostgraduateDiploma/MSc.

Further informationDr Mike CattellTel: +44 (0)20 7377 7000 ext 2160email: [email protected]

MSc inExperimental OralPathology (OralSciences)One year full-time

Programme descriptionThis one year full-time programmeis designed as an introduction tothe principles of experimentalpathology applied to oral disease.It is principally intended toprovide a grounding inexperimental method for dentalgraduates who plan to followeither a career in academicdentistry or one of the clinicalspecialities. It also provides anopportunity for science graduatesto learn about oral disease, inpreparation for a career in dentalresearch. The programme offersfundamental training in theprinciples of laboratory researchmethods and the range oftechniques used to study thebehaviour of oral tissues in healthand disease.

Programme outlineYour programme will be modular,focused on acquiring laboratoryskills and knowledge. The taughtmodules provide the basicunderstanding to help with theresearch component. There is astructured course of seminarswith associated practical work,dealing with the structure andbehaviour of cells and tissues inhealth and disease. This corebegins with fundamental andgeneral concepts of cell biology


and continues with the applicationof these concepts to aconsideration of oral and dentaldisease. Related disciplines suchas oral microbiology andimmunology are also covered.

Throughout the programme,emphasis is placed on theevidence upon which theconcepts are based and the way in which such evidence isobtained by observation andexperiment. You are activelyencouraged to take part in theseminars.

Running in parallel with the coreprogramme are several relatedseries of seminars dealing withresearch methods, statistics and techniques of fundamentalimportance to experimentalpathology such as tissue culture,molecular biological techniques,immunocytochemistry, light andelectron microscopy.

Students undertake a laboratory-based research project in the finalmodule of the programme,exploring any aspect of oraldisease.

AssessmentThe programme is assessed by two written papers, thesubmission of a project report and an oral examination.

Entry requirementsA degree in dentistry or medicineor a good BSc honours in abiological science subject.


Further informationDr Alan Cruchley Tel: +44 (0)20 7882 7134email: [email protected]

or

Dr L BergmeierTel: +44 (0)20 7882 8654email: [email protected]

Studied: MSc in Experimental Oral Pathology – graduated 2006

Currently: PhD in Dentistry

Why did you choose Queen Mary?I chose Queen Mary, because ofthe diverse cultural environment but more importantly, its reputationas a University par excellence for high quality teaching and researchin Dentistry.

What did you gain from your time at Queen Mary?I researched the role of Human Papilloma-virus 16 (HPV16) in Oralcancer at the new, open plan Blizard Building, which providedaccess to excellent facilities and the opportunity to collaborate with a diverse range of research groups. I particularly enjoyed presentingmy research via posters at international conferences, such as theBritish Society of Oral and Maxillofacial Pathologists day. I wasprivileged to get a publication in an international journal and therare chance of meeting high profile clinicians, researchers andexecutives. Overall, my experience on the MSc was so enjoyablethat I inevitably wanted to continue my research here. Aftergraduating with a Distinction, I am delighted to now be a PhDstudent, researching diagnostic imaging for oral mucosal diseases.

What your career plans in the next five years?On completion of my PhD at Queen Mary, I intend to undergo aspecialist training in Oral Pathology with a view to having anexcellent background in the pathologic basis of Oral diseases.

Graduate profile: Oluyori Adegun



MSc in ImplantDentistryOne year part-time

Programme descriptionFor dentists wishing to upgradetheir core knowledge and skills of evidence-based dentistry inidentifying and understanding thescientific basis of implanttreatment.

Programme outline The programme includestimetabled seminars, personalstudy and supervised research. All programme taught modulesare core options, although yourhave considerable choice whenselecting a research topic. Thetaught modules’ content includes:

• Searching, critically reading and analysing the literature

• Formulating appropriatehypotheses for investigation

• Demonstrating knowledge ofclinical techniques and how to evaluate them

• Interpreting the results of these techniques

• Planning, conducting andreporting original research.

Students are encouraged todevelop appropriate key written,oral, group work and timemanagement skills.

Assessment The assessment procedures are:

• a research report on an individual project

• an oral examination on your research report.

Candidates will be examined inthe year in which they completetheir research report.

Entry requirementsYou should have successfullycompleted the two-year part-timeDiploma programme in ImplantDentistry, accredited by theFaculty of General DentalPractitioners of the Royal Collegeof Surgeons of England.


Further informationDr Gianlucca MartuscelliTel: +44 (0)20 7882 8663email: [email protected]


MSc in OralBiologyOne year full-time

Programme descriptionYou will join a one year full-timeprogramme, the only UK MSc inOral Biology. It is designed to beappropriate for both dental andbasic or applied sciencegraduates who may in future beresponsible for the teaching ofrelated subjects, or who need agreater understanding of thesubject in order to develop theirfuture academic or researchcareers.

Oral Biology encompasses a rangeof basic sciences fundamental tothe understanding of theunderlying scientific principlesrelevant to developing moderndentistry. You will study dentalanatomy, oral physiology, anddental biophysics, as well as basic biochemistry in relation todentistry, chemistry of bone andtooth biominerals andcomponents, aetiology of dentalcaries and erosion, salivabiochemistry, oral microbiology,dental materials science, modern2D and 3D x-ray imaging.

Programme outlineYou will follow a group ofmodules, including Statistics,Ethics and Research Methods, an Introduction to Oral Biology,Dental Hard Tissues and theMicroenvironment, OralMicrobiology, Minimally InvasiveDentistry and Properties of DentalMaterials. In addition to these

basic science lectures, there willalso be lectures from practisingclinicians on current issues inmodern clinical dentistry.

You will also complete a laboratorybased project, which will be partlyassessed by an oral examination.

Entry requirementsA medical or dental degree, anon-clinical degree in basicsciences, biological sciences, orbioengineering, or the equivalentin professional qualifications andexperience.

A minimum IELTS score of 6.5 (or an equivalent alternativequalification) is also required foroverseas students where Englishis not the first language.

Further informationDr Paul AndersonTel: +44 (0)20 7883 7933email: [email protected]

PostgraduateDiploma inEndodontic PracticeTwo years part time

Programme descriptionThis programme is designed fordental graduates who wish todevelop their clinical skills in andunderstanding of endodontics.The aim is to enable thepractitioner to develop and applythe current evidence base to theirclinical practice.

Programme outlineBy entering this programme youwill embark on: clinical training(30 per cent), laboratory practicalsessions (25 per cent) formalseminar teaching (45 per cent).All modules in this programmeare core.

AssessmentYour progress will be monitoredthroughout the programme byformative in-course assessments.These may include essays, criticalpaper reviews and practical testsof laboratory based skills. Oncompletion of the programme, you will be assessed by twoclinical case reports of not morethan 2,000 words each and anoral examination. Your in-courseassessments will contribute up to40 per cent, the two clinical casereports up to 40 per cent and theoral examination up to 20 percent of your final mark.



Entry requirementsYou will have a UK dental degreeor equivalent (such as IQE), holdfull registration with the GeneralDental Council and have aminimum of two years post-initialqualification experience. Offers tojoin the programme follow acompetitive interview.


Further informationChathura MalalasenaTel +44 (0)20 7377 7057email:[email protected]

or

Dr Sharan SiddhuTel: +44 (0)20 7882 8617email: [email protected]

MClinDent in OralMedicineTwo years full-time

Programme descriptionThis programme is designed fordental graduates who wish topursue a career in oral medicine,either in primary or secondarycare services or in a universitysetting. The programme aims todevelop your knowledge,understanding and clinical skillsin oral medicine and relatedtopics.

Programme outlineBy entering this programme youwill embark on: clinical training(60 per cent), formal teaching (25 per cent) and researchactivity (15 per cent). Theprogramme aims to enable you tounderstand basic sciences relatedto oral medicine and apply this toNorth and East London’s uniqueclinical case mix. All the taughtand clinical modules in theprogramme are core teaching.The research element of thisprogramme involves a report or aliterature review on a topic chosenwith the advice of your tutor and aclinical audit report.

Assessment Your clinical activity will beassessed through casepresentations and a clinicallogbook whilst the taught elementwill be assessed through onewritten paper and oralassessment. Your research activitywill be assessed by a report of aliterature review on a topic chosenwith the advice of your tutor and aclinical audit report. Weightings ofeach of the major components willreflect their contribution to theprogramme: clinical training (60per cent), formal teaching (25 percent), and research activity (15per cent).

Entry requirementsPlease refer to the personspecification table for all clinicalmasters programmes in Dentistryon page 75.


Further informationDr Anwar TappuniTel: +44 (0)20 7882 8655email: [email protected]

or

Ryan Salucideenemail: [email protected]

MClinDent in Oral SurgeryTwo years full-time

Programme descriptionThis programme is designed fordental graduates who wish topursue a career in oral surgery,either in primary or secondarycare services or in a universitysetting. It can contribute to thefirst two years of clinical trainingleading to the Membershipexamination of The Royal Collegeof Surgeons.

Programme outline By entering this programme youwill embark on: extensive clinicaltraining (60 per cent) formalteaching (25 per cent) and asupervised research project (15per cent). All the taught andclinical modules in theprogramme are core modules.You will however haveconsiderable choice whenselecting a topic for your researchproject.


The full programme includespatient diagnosis and treatmentplanning, teeth and rootextraction, surgical endodontics,management of dental trauma,implantology and painmanagement, and anxiety control.

AssessmentYou will be assessed at the end of the first year through a writtenpaper and a clinical viva voceexamination. At the end of thesecond year there are two writtenpapers, four case presentations(two seen and two unseen) and atreatment planning exercise. Youwill also take part in an oralassessment of your researchreport.

At the moment all three majorcomponents of the second yearexams (written, clinical, research)are equally weighted.

During an optional additional thirdyear, you will undertake, if eligible,the Royal College of SurgeonsMembership examination. Thisentails case presentations, clinicaldiagnostic and treatment planningexercises.



Further informationDr Judith JonesTel: +44 (0)20 7882 7154email: [email protected]

MClinDent inOrthodonticsTwo years full-time

Programme description This programme is designed fordental graduates who wish topursue a career in orthodonticseither in primary or secondarycare services, or in a universitysetting. The two-year full timeMasters programme is integratedinto a three-year clinicalprogramme, with a strongemphasis on close chairsidesupport. Students will undertakethe MSc examination (Universityof London) at the completion oftheir second year and the RoyalCollege of Surgeons Membershipexamination during the third year.The programme aims to enableyou to:

• Understand the biomechanicalprinciples of tooth movement

• Understand the development,growth and influence of theskeletal and soft tissues on thedentition

• Understand the importance of materials science inorthodontics

• Formulate a diagnosis ofmalocclusion and appropriatetreatment plan

• Apply the theory and practice of clinical orthodontics to treat a variety of malocclusions.

Programme outline By entering this programme youwill embark on a course whichincludes extensive clinical training(60 per cent), formal teaching (25per cent) and a supervisedresearch project (15 per cent). Allthe taught and clinical modules inthe programme are core teaching.

‘‘‘‘

Bana Abdulmohsen, MSc DentalTechnology, Syria

Queen Mary has a goodreputation amongst Syrianstudents. A friend of minehighly recommended studyinghere at postgraduate level. Ithas been a great opportunity to meet colleagues in the samefield and exchange knowledge.The College itself is a reallyfriendly environment, withgreat facilities such as theLibrary, computers andmodern accommodation.

Ideally I would like to teach aswell as practise dentistry, andhope to apply for a PhD atQueen Mary. I enjoy attendingconferences and learningabout up to date research. I would also like to work onsome research and publisharticles.



You will however haveconsiderable choice whenselecting a topic for your researchproject. The three-yearprogramme includes the followingareas:

• Growth and development of thehead, face and dentition

• Anatomical and physiologicalconsiderations of the face andjaws, including thetemporomandibular joint

• The aetiology of malocclusion

• Clinical assessment, diagnosisand treatment of malocclusion

• State-of-the-art treatmentmechanics

• Concepts and practice ofretention and stability

• Inter-disciplinary care, includingsurgical and restorativeinterfaces.

AssessmentYou are currently assessed at theend of the second year (MScexamination) by two writtenpapers, case presentations, aclinical diagnostic and treatmentplanning exercise. You will alsotake part in an oral assessment ofyour research report. During thethird year, you will undertake, ifeligible, the Royal College of Surgeons Membershipexamination (M.Orth). This entailscase presentations, clinicaldiagnostic and treatment planningexercises.

Entry requirementsPlease refer to the personspecification table for all clinical

masters programmes in Dentistryon page 75.


Further informationLorraine Low Tel: +44 (0)20 7882 8744 email: [email protected]

or

Dr Ama JohalTel: +44 (0)20 8662 8651 email: [email protected]

MClinDent inPaediatric DentistryTwo years full-time, three yearspart-time

Programme description This programme is designed fordental graduates who wish topursue a career in paediatricdentistry either in primary orsecondary care services, or in auniversity setting. The programmecan contribute the first two yearsof clinical training leading toMembership in PaediatricDentistry of The Royal College of Surgeons, Edinburgh and fullactive membership of theEuropean Academy of PaediatricDentistry. Both of these optionsare possible following successfulcompletion of an optional thirdyear of training which is availablethrough competitive entry.

Programme outline By entering this programme youwill undertake extensive clinical,

formal teaching and a supervisedresearch project. All the taughtand clinical modules in theprogramme are core modules butyou will have considerable choicein selecting a topic for yourresearch project.

The programme comprises nine modules:

1 Foundation Course

2 Statistics, Ethics and ResearchMethods

3 Basic Knowledge in PaediatricDentistry including the following:

• Behaviour science/patientmanagement, sedation andgeneral anaesthesia

• Dental Traumatology

• Prevention of Caries andPeriodontal Disease

• Diagnosis and TreatmentPlanning

• Basic Orthodontics

4 Advance Knowledge inPaediatric Dentistry I

• Consolidation of the BasicKnowledge

• Oral Surgery, Oral Medicine and Oral Pathology

• Children with special needs

5 Advance Knowledge inPaediatric Dentistry II

• Paediatric medicine and surgery

• Dental Anomalies

• Multi-disciplinary treatmentplanning


6 Basic Clinical Skills and case-mix

7 Specific Clinical Skill

8 Clinical Diagnosis and Treatment Plan

9 Research Project

You will undertake the care ofchild and adolescent patients togain experience and prepare foryour case presentations in thefinal examination. An importantfeature of the programme is thatyou will also participate in medicalclinics held in the main hospital.You will also attend specialistclinics such as cleft lip andpalate, and developmentaldisorders.

AssessmentEach module is assessedseparately, including essays,written, clinical and viva voceexaminations.



Further informationLorraine Low Tel: +44 (0)20 7882 8744 email: [email protected]

or

Professor Mark Hector Tel: +44 (0)20 7882 8676 email: [email protected]

or

Dr Ferranti WongTel: +44 (0)20 7882 8745email: [email protected]

MClinDent inPeriodontologyTwo years full-time

Programme description This programme is designed fordental graduates who wish topursue postgraduate leveleducation or a career inPeriodontology. The programme isrecognised by the UK SpecialistAdvisory Committee in RestorativeDentistry as suitable for the firsttwo years of specialist training inPeriodontology. An optional thirdyear of training is availablethrough competitive entry forUK/EU applicants wishing to beentered on the GDC specialist list.This option must be agreed byThe London Deanery prior toentry.

Programme outline The programme consists ofclinical training, formal taughtelements and the completion of aresearch project and dissertation.The clinical training (60 per cent)in diagnosis and management ofperiodontal disease emphasisesthe practice of advancedtechniques in periodontology andincludes the relationship betweenperiodontology and other dentaldisciplines. The formal teachingelement (25 per cent) is designedto provide a wide scientificbackground in the practice ofperiodontology. The supervisedresearch project consists of 15per cent of total programmeactivity.

All the taught and clinicalmodules in the programme arecore modules. However, you havea wide range of opportunities andtopic choices for the researchproject in our exemplary modernresearch laboratory and clinicalfacilities. The full programmeincludes attendance at weeklynew patient diagnostic clinics,


clinical practice in periodontologyincluding surgical, antimicrobial,regenerative and mucogingivalprocedures, management ofperiodontal disease in patientswith other restorative problems,and principles and practice ofimplant dentistry.

AssessmentYou are currently assessed at theend of Year One by a singlewritten examination paper and aclinical oral examination on thescientific basis of Periodontology.At the end of the second yearthere are two written papers, fourcase presentations, and a clinicaldiagnosis and treatment planningtest. You will also produce awritten report of your researchproject. You will also take part inan oral assessment of yourresearch report. At the moment all three major components of thesecond year exams (written,clinical, research) are equallyweighted.



Further informationDr Kevin SeymourTel: + 44 (0)20 7882 8663email: [email protected]

MClinDent inProsthodonticsTwo years full-time

Programme description This programme is designed fordental graduates who wish topursue a career in Prosthodontics.It can contribute to the first twoyears of the three year clinicaltraining leading to Membership in Restorative Dentistry (MRD) ofThe Royal College of Surgeons,Edinburgh. Membership isgranted following successfulcompletion of an optional thirdyear of training without additionalexamination. This option is onlyavailable through competitiveentry. For UK/EU applicantswishing to be entered on the GDCspecialist list this option must beagreed by The London Deaneryprior to first year entry.

Programme outline The programme comprisesextensive clinical training (60 percent), formal teaching (25 percent), and a supervised researchproject (15 per cent). All thetaught and clinical modules onthe programme are core options.You will have considerable choicewhen selecting a topic for yourresearch project.

The programme includes modulescovering all aspects of fixedprosthodontics, removableprosthodontics, implantology and related subjects.

You will value the opportunity ofattending new patient diagnosticclinics, providing you with theopportunity of formulatingcomplex treatment plans.

AssessmentYou will currently be assessed atthe end of year one by a singlewritten examination paper and aclinical oral examination. At theend of the second year there aretwo written papers, two casepresentations (four for the MRDcandidates), a treatment planningexercise, and a clinical test inboth fixed and removableprosthodontics. You will also takepart in an oral examination of yourresearch report.

At the moment all three majorcomponents of the second yearexams (written, clinical, research)are equally weighted.



Further informationDr Paul D TaylorTel: +44 (0)20 7882 8619 email: [email protected]



Person specification for entry to postgraduateclinical dentistry programmes

1 You may not apply for more than one speciality inthe hope of acceptance on one. We do though recommend applicants considerapplication for the Diploma in Dental ClinicalSciences course here prior to applying for any of theclinical programmes as it will show commitment andallow us to assess the candidates’ work ethic andknowledge before any decisions are made.

2 The personal statement should show genuineenthusiasm for the speciality, such as attendance at relevant conferences, membership of appropriateprofessional bodies and postgraduate courseattendance and not be generic in nature.

Education

Experience

English Language

Career intentions

Generic skills

Primary qualification in Dentistry - BDSor equivalent.

Two years full time (or equivalent) postqualification clinical practice of dentistry.

English as first language

OR

Minimum IELTS score of 7.0 (no lessthan 6.5 in any part), TOEFL scores asfollows: internet based 106, computerbased 263, paper based 627 and musthave been completed within the last twoyears.

Clear commitment to pursuingpostgraduate studies in the onespecialty/discipline applied for.

Ability to use a computer and familiarwith common programs such as MSOffice.

Primary dental qualification registerablewith the General Dental Council in theUK;

MFDS, MJDF or FDS or equivalent;

Other postgraduate diplomas, degrees;

Other evidence of high academicachievement (eg Course grades, awardof degree with honours or equivalent.Previous first degree [-BSc]).

Evidence of experience of practice of a broad range of general dentistry;Completion of formal Vocational Trainingcourse, General Professional Trainingprogram, or equivalent such as hospitalinternship. Specific clinical experiencein discipline/specialty to which they areapplying.

Other equivalent tests will be consideredon merit.

Criterion Essential Desirable

Institute of Health Sciences Education


Institute of Health Sciences Educationwww.ihse.qmul.ac.uk

Institute DirectorProfessor Susan Dillyemail: [email protected]

Director of Graduate StudiesProfessor Clive Sealeemail [email protected]

It comprises three Centres:

• Centre for Medical Education

• Centre for Health Sciences

• Centre for Sports and ExerciseMedicine

Centre for Medical Education The Centre is concerned withmanaging, maintaining anddeveloping teaching. The majorityof staff are involved in teaching,largely undergraduate, but alsosome postgraduate modules.

The units within the Centre are asfollows:

Quality and EducationDevelopmentThis unit concentrates on qualityassurance of teaching, facultydevelopment and educationresearch

Curriculum DeliveryThis unit concentrates on thedelivery of teaching within the MBBS and degree programmes

Human Development This unit leads teaching onwomen’s health, paediatrics and medicine for the elderly.

AssessmentThis unit leads in managingassessment within the MB BScourses.

E-LearningThis unit is developing E-learningfor undergraduate modues, andis working closely with IVIMEDS,the international virtual medicalschool, developing virtual patientsand interactive E-learning.

Turnbull CentreThis unit manages and deliversteaching in the Turnbull Centre,delivering anatomy and medicalsciences practical teaching.

Performing MedicineThis unit is a collaborative projectdelivering a programme of arts inmedicine. The Centre runs anintercalated degree in MedicalEducation.

Centre for Health Sciences The Centre includes two researchorientated units: The GeneralPractice and Primary CareResearch Unit and HumanScience and Medical EthicsActivities which are consolidatedon the Medical School’sWhitechapel Campus, adjacent tothe Royal London Hospital. Thegeographical position of theCentre for Health Sciences in eastLondon, with the surroundingmulticultural population spanningthe economic spectrum, providesa major focus for our researchprogramme.

We use a wide range ofmethodological approaches,ranging from observationalepidemiology, social surveys and randomised controlled trials,through systematic reviews, toqualitative studies and healthpolicy research to inform thedevelopment of health and socialcare services.

The research programme includes five linked domains:

1. Inner-city health servicedelivery including:

• ethnicity and healthcarevariation

• inequality in health service use and outcomes

• Mass media reporting of health topics

2. The evaluation of models of primary and social caredevelopment, including:

• healthcare responses todomestic violence

• primary care development

• evaluation of small areavariations in health andhealthcare

• Communication in health care consultations

• End-of-life decision-making


Institute of Health Sciences Education

3. Chronic disease managementincluding:

• cardiovascular disease

• asthma, COPD and tuberculosis

• chronic musculoskeletal pain

4. Health services research

• analysis of routine data statistics

• decision aids in healthcare

• models of service delivery

• ethical aspects of research,policy and delivery in publichealth and healthcare services

• statistical method for communitybased research

5. Ethnicity and Health

• evaluation of a schoolcounselling service forBangladeshi girls who self-harm

• ethnic health behaviours inrelation to prostate cancer

• lifestyle narratives of ethnicadolescents in relation to health behaviour

Centre for Sports and Exercise MedicineThe Centre includes two major domains:

• The high performance athlete

• Health and the generalpopulation, physical activitylevels and exercise as a healthtool


Cathy Baker BSc PhDSenior Lecturer in Histopathology;Head of Graduate Entrants’Programme (GEP); Senior Tutorfor Medical AdmissionsDr Baker’s interests in educationinclude selecting the beststudents, student learning styles,curriculum development andinter-professional education.

Mark Carroll BSc PhDSenior Lecturer in Biochemistry;Senior Tutor for Education QualityDr Carroll’s interests are inbiochemical education,educational quality and facultydevelopment.

Vivien Cook BSc PGCE MA EdDSenior Lecturer in the Centre forMedical EducationDr Cook is an educationalist withinterests in faculty development,work-based, non-formal learningand qualitative research methods.She teaches educational theoryand practice within the MB BSprogramme and BSc in MedicalEducation.

Susan Dilly BSc MB BS FRCPathProfessor Dilly joined Barts andThe London in September 2006as Director of the Institute forHealth Sciences Education andAssociate Dean for UndergraduateMedical Education. As anHonorary ConsultantHistopathologist for Barts and TheLondon NHS Trust, shespecialises in perinatal pathology.

Sandra Eldridge MSc(Lond)PhD(Lond)Professor of Biostatistics, Directorof the UKCRC registeredPragmatic Clinical Trials UnitProfessor Eldridge’s specificmethodological research interestsare in cluster randomised trials,and in modelling process data inpilot studies in order to inform thedesign of trials. Methodologicalwork includes the largestsystematic review of themethodology of empirical clusterrandomised trials, and work onsample size calculations andinternal and external validity ofthese trials. She is currentlycollaborating on a large number ofpragmatic clinical trials includingthose concerned with the care ofasthma, chronic obstructivepulmonary disease and angina.She also has a wider interest inthe quantitative research methodsused in primary health care and isa leading figure in the RoyalStatistical Society primary healthcare study group, which providesa forum for those working in thisarea to exchange ideas aboutquantitative methods and learnfrom each other. She is on theeditorial board of Family Practice.

Jon Fuller MB BS BSc FRCGPMHPEdSenior Lecturer in MedicalEducation, Centre LeadDr Fuller is a General Practitionerin Hackney. He trained in medicaleducation at Maastricht University,Netherlands. His interests includefaculty development, teachingabout education, developingeducational quality andcurriculum development.

Christopher Griffiths MADPhil(Oxon) FRCP(Edin) FRCGPProfessor of Primary CareProfessor Griffiths has been aGeneral Practitioner in Hackneyfor twelve years and a Trustee ofAsthma UK for three years. Hismain research interests are healthinequalities and ethnicity, relatingin particular to asthma, chronicobstructive pulmonary diseaseand tuberculosis. He currentlyserves on the development groupsfor NICE guidelines for type IIdiabetes and tuberculosis, and for the BTS/SIGN national asthmaguidelines. He is an internationaleditorial board member of thejournals Thorax and the PrimaryCare Respiratory Journal.

Nicola Maffulli MD MS PhDFRCS(Orth) DipSportsMed Centre Lead and Professor ofSports and Exercise MedicineProfessor Maffulli's continuingresearch interests are varied, andreflect his training in molecularbiology, cardiovascular physiology,and musculo-skeletal medicine.The recent research thrust hasbeen in the genetics oforthopaedic conditions, in tissueengineering of tendons, andmesenchimal stem cell therapy fortendinopathy. He performs clinicalresearch on tendinopathy, andhas carried out many randomizedcontrolled trials in musculo-skeletal medicine. During theyears, Nicola has established ahost of collaborations in the UKand abroad, and has leadmultidisciplinary research teamsin multicentre trials.

Senior staff research interestsInstitute of Health Sciences Education


Senior staff research interestsInstitute of Health Sciences Education

Adrian Martineau, B Med SciDTM&H MRCPClinical Lecturer in Centre forHealth Sciences and alsohonorary research fellow inDivision of Mycobacteriology atNational Institute of MedicalResearch and Department ofMedicine, Imperial College.Dr Martineau’s interests includeimmunomodulatory actions ofvitamin D in respiratory infection,and pathogenic / protective role ofneutrophils in tuberculosis. Hiswork includes in vitro studies andclinical trials.

Dylan Morrissey PhD MScMMACP MCSPConsultant Physiotherapist andSenior Clinical Lecturer in Sportsand Exercise Medicine.Dr Morrissey combines clinicalactivity at Tower Hamlets andBarts and The London NHStrusts, with an academic role inthe Centre for Sports and ExerciseMedicine. His main researchinterest concerns the link betweenmovement and pathology, with anumber of studies ongoing in thenewly re-equipped HumanPerformance Laboratory.Collaborators include groups at Queen Mary, SouthamptonUniversity and King’s CollegeLondon. Other research interestsinclude the translation of evidenceinto clinical practice and optimalmethods of inter-professionaleducation. He runs the MScsports injury assessment modulesand is course lead for theintercalated BSc in SEM.

John Patterson BSc PhDAssociate Dean for UndergraduateMedical Studies and Head of MBBS assessmentDr Patterson is responsible for MB BS degree regulations,assessment strategy andacademic aspects of all MB BSassessments. His academicinterests are in good assessmentdesign (including assessmentreliability) and standard settingmethodologies. He is Barts andThe London co-ordinator for agroup of four UK medical schoolspiloting progress testing inassociation with the US NationalBoard of Medical Examiners.Formerly he has been Chair of the University of London ExtendedMatching Question Bank

Clive SealeProfessor of Medical Sociology,Lead for Human Science andMedical EthicsProfessor Seale’s researchinterests include palliative andend-of-life care, communication in health care settings, the massmedia, internet and health, andsocial research methods. His workinvolves the use of a variety ofsocial research methods,including social surveys anddifferent forms of qualitative datacollection and analysis. He editsthe journal Sociology of Healthand Illness.

Stephanie Taylor MB BS MscMD(Lond)Reader in Applied ResearchDr Taylor is a part-time salariedGeneral Practitioner and is alsoaccredited in Public Health. Her

research interests includecomplex interventions for themanagement of chronic disease in the community with particularreference to heart failure, chronicobstructive pulmonary diseaseand chronic pain. Long-terminvolvement with a largelongitudinal study of adolescenthealth in east London(www.relachs.org) has led to a research interest aroundadolescent overweight and obesityand its prevention. She hasexperience in the synthesis of research evidence,epidemiological field studies andclinical trials. She is an editorialboard member (and deputy editorelect) for the journal Perspectivesin Public Health (formerly Journalof the Royal Society of Health).


Robert Walton BSc MD FRCPFRCGP DCHProfessor of Primary Medical CareProfessor Walton is a GeneralPractitioner, his research interestsare genetics andpharmacogenetics, smokingcessation and chronic liverdisease. His work involvesapplication of molecular medicineand novel diagnostic tests inPrimary Care. He is currentlyinvestigating personalisedtreatments for tobacco addiction,performing studies on geneticaspects of therapy for tuberculosisand malaria and working on teststo identify those at high risk ofcomplications from chronic viralhepatitis (hepatitis B and C) suchas cirrhosis and liver cancer.

Olwyn Westwood BScPhD(FIBMS; FHEA)Professor of Medical EducationProfessor Westwood has workedfor around 20 years in medicaleducation. She co-ordinated theset-up of the curriculum and itslaboratories for the Graduate EntryProgramme in Medicine atSwansea, then became theprogramme director. She has a keen interest in making thebiosciences both accessible and relevant to medicine.

Patricia Revest BA PhDSenior lecturer in Medical Studies.Dr Revest joined the educationsection of the medical school in2000 and is currently Head of theYear One MB BS. With an interestin E-learning Patricia Revest isalso head of the SMD E-LearningUnit and leads on a number of E-

learning projects includingIVIMEDS (International VirtualMedical School). She is author ofa number of student textbooksincluding The Nervous System(Michael-Titus, Revest andShortland, 2007) and MedicalSciences (ed. Naish, Revest andSyndercombe Court, 2009).

Michael Roberts MA(Med Ed) MDFCRP ILTHE Professor of Medical Education for Clinical Practice, Dean forStudents and Head of Year five,Consultant Physician WhippsCross University HospitalProfessor Roberts’s clinicalresearch interests include COPDand oxygen therapy. He isAssociate Director of the ClinicalEffectiveness and Evaluation unitof the Royal College of Physiciansof London and leads the nationalCOPD audit programme for theUK. Education research includesthe transition from undergraduateto postgraduate medicine and E-learning. He is currently involvedin research projects with theDepartment of Health andLiverpool University.

MRes in MedicalResearch One year full-time; two years part-time(Subject to approval)

Programme description This programme offers anopportunity to gain an excellenttraining in generic research skills.This is achieved through taughtmodules as well as conducting a

novel research project. Oncompletion, you will be well-equipped to undertake a doctoralprogramme of study.

Programme outlineModule options include:Governance framework andresearch management • Criticalevaluation • Engagement with awider audience • Presentationskills • Dissertation literaturereview

AssessmentYou will be assessed through a series of written and oralpresentations including: Criticalevaluation of a research method• Application to an ethicscommittee • Referees report of a paper and a grant proposal •Literature review • Proposal for a pilot study • Report of the pilotstudy (written, poster and oralpresentations) • Fellowshipproposal/grant application • Pressrelease, topical article and oralpresentation • Criticalpresentation of research papers

Entry requirements For entry on to the programmestudents will need either MB BS,BDS or a BSc with an uppersecond class honours in anappropriate subject.

Further informationProfessor Joy HinsonTel: +44 (0)20 7882 2090email: [email protected]


Taught programmesInstitute of Health Sciences Education

MSc/PostgraduateDiploma in PrimaryCareOne year full-time, two years part-time

Programme description This is a flexible, modular,multidisciplinary programme thataims to facilitate learning in topicsthat are meaningful to all primarycare staff including GPs. Itcaptures the rapid developmentsthat are taking place in PrimaryCare, and is designed to providenew and exciting learningopportunities which will enhanceyour work experience.

This programme is run jointly withCity University and offers you adiverse range of routes. The oneyou choose to follow will dependon your career aspirations. Youcan either complete eightmodules to attain thePostgraduate Diploma or continueto Masters level by submitting a15,000 word dissertation.Modules can also be taken as‘stand alone’ modules as part ofyour personal development plan,as required by the NHSknowledge and skills framework.

Programme outline The programme offers four routes:

• Primary Care Route: a flexibleroute which allows students tochoose from a wide range ofoptions to meet their individuallearning needs

• District Nursing Route

• Long Term Conditions Route:particularly designed to meetthe needs of those incommunity matron/casemanager roles

• Advanced Nurse PractitionerRoute: RCN accredited route forthose who wish to develop theirskills as advanced practitioners

For the full list of modules androute structures, please see theprogramme website:www.ihse.qmul.ac.uk/chs/education/primarycare

Each module includes 30 hours ofgroup teaching. Students are alsoexpected to spend 120 hours foreach module on private study(reading, preparation for sessions,project work and assignments).

Assessment The programme consists of both formative and summativeassessments. Students arerequired to complete anassessment at the end of eachmodule. These include essays,presentations, reflective essaysand an unseen written exam. Inorder to obtain the Masters awarda 15,000 word dissertation mustalso be completed Students whohave obtained the PostgraduateDiploma in Primary Care mayconvert this to a Masters degreeby submission of the preparatorywork and then the finaldissertation, any time up to fiveyears after starting theprogramme.

Entry requirementsThe programme requires asuitable level of prior academicachievement and/or practicalexperience of deliveringhealthcare, either personally or ina managerial capacity. This canbe shown by a medical, nursingor dental qualification of anappropriate standard, plusrelevant professional experience.This can also be demonstrated bya good honours degree in anothersubject plus relevant professionalexperience. Applicants for aMasters Degree are usuallyrequired to have achieved anupper second class honoursdegree or equivalent standard inother qualifications. Applicantswith other qualifications plusrelevant experience, or withoutprofessional qualifications but withextensive relevant experience, willalso be considered.


Further informationProgramme AdministratorTel: +44 (0)20 7882 2541email: [email protected]/chs/courses/primarycare


MSc/PostgraduateDiploma in PublicHealthOne year full-time, two years part-time

Programme description This programme is run jointly byQueen Mary, University of Londonand City University. This highlypractical programme aims toenable you to develop the skillsand knowledge to become aleader in public health, healtheconomics or food policy andpractice. By the end of theprogramme, you will also have theopportunity to cover the majorityof the skills and knowledgerequired for the MFPHM part 1examination. It offers studentsfrom a wide range of disciplinesthe opportunity to study practicalaspects of public health with astrong emphasis on current publichealth issues, food policy orhealth economics.

Programme outline The programme offers four routes:

• Public Health

• Health Economics

• Food Policy

• Community Public HealthSpecialist Practice Nursing:Health Visiting; School Nursing;District Nursing

For the full module list and routestructures, please see theprogramme website:

www.ihse.qmul.ac.uk/chs/education/publichealth orhttp://www.city.ac.uk/study/courses/communityhealth/public-health-msc-pgdip.html

Each module includes 30 hours of group teaching and 120 hoursprivate study for each module.

‘‘‘‘Carol Rivas, PhD in Social andCultural Contexts and DomesticViolence

I’m looking at the effect thatculture has on women’sresponses to psychological abusefrom a male partner. I amparticularly interested in howwomen deal with their situation

and how they manage their social identities when they stay within therelationship. I have interviewed Caribbean, African and white Britishwomen for the study.

I think all three campuses are great for different reasons and it isnice that you can make use of the facilities at all three. The librariesare well resourced and there are libraries at each campus which isuseful – you can return or renew at all of them interchangeably. Ihave found the staff to be nurturing and keen for me to get a goodquality PhD. I work with some leading experts in my field who arevery accessible and who also present great networking and otheropportunities.

There are great opportunities to mix at Queen Mary, from thepersonal development courses to curry nights, barbecues, specialtalks and so on. There is also a performance arts group, whosometimes provide free ‘theatre’ workshops and shows. The gymhas a women only room. There are several good eateries both withinand outside the college (some of them are of very high quality butstill reasonably priced), and the canal and park at Mile End. Themarket at Whitechapel is vibrant and useful for bargains.

I also help out with teaching, which I love, and taking childrenround the Centre of the Cell, which is the amazing new interactiveexhibition at Whitechapel. I am also a science ambassador forschools, which means I go to special events for schools to promotescience as a career. This might involve conducting mock jobinterviews, helping children do experiments or talking about mywork. Last year I took children around the Big Bang, which alsogave me the chance to enjoy it and have a go at everything.


Taught programmesInstitute of Health Sciences Education

AssessmentThe MSc requires the completionof six core modules, two optionmodules and a dissertation.Option modules are taken fromprogrammes at both CityUniversity and Queen MaryUniversity.

Diploma students will be requiredto complete eight modules only.Assessment varies per moduleand may include: essay writing, a policy paper or article suitablefor submission for peer reviewpublication, an oral or posterpresentation of work, completing a reflective learning diary andcompleting a grant proposal form.Many or all the projectsundertaken by students on thisMSc will be closely related to yourdaily work.

Entry requirementsWe recognise professionalexperience from a wide range of relevant backgrounds in thepublic sector, with a minimum oftwo years’ professional experiencefor applicants together with atleast a second class honoursdegree. International studentsneed to have a degree-levelqualification in an area related to public health, and equivalentprofessional experience.


Students in local PCTs mayundertake this programmethrough the NHS LondonCommissioning Contract with

City University with supportingdocumentation.

Further informationCaroline HumphreyAcademic Administrator MSc Public Health, School ofCommunity and Health Sciences City University, 20 BartholomewClose, London EC1A 7QN

Tel: +44 (0)20 7040 5470email: [email protected]/chs/courses/publichealth

Graduate profile: Dan Lewindon

Studied: MSc in Sports Medicine, graduated 2007

Currently: I work full-time as Senior Physiotherapist for NorthamptonSaints RFC and as a locum physiotherapist for England RFU.

Why did you choose Queen Mary?As a physiotherapist working in professional rugby, it was always myintention to complete an MSc in Sports Medicine both to improve myunderstanding and expertise in this rapidly evolving field. After muchresearch I found Queen Mary to be the best programme for my needs.It offered the best mix of ‘foundation’ modules in assessment andinjury management, and modules of interest and innovation, includingteam medicine, podiatry/ biomechanics and injection therapy. Theflexibility of the programme also allowed me to limit time lost from workand spread the workload, which was essential in placating myemployers.

What did you gain from your time at Queen Mary?Although by no means easy and often requiring significant personalsacrifice, the MSc has been an extremely worthwhile experience forme, both with regard to my work within sport and also in generalpractice. It has improved the quality of my assessment skills and myability to generate rehabilitation plans, which are criteria driven andevidence-based. I also gained an insight into the latest innovations ininjury management and had the opportunity to network with leaders inthe field of sports medicine, both lecturers on the programme andthrough organised shadowing sessions. I would whole-heartedlyrecommend this programme to any physiotherapist with an interest insports medicine or an intention to work in the field.


MSc/PostgraduateDiploma in Sportand ExerciseMedicineOne year full-time, two to fouryears part-time

Programme description This internationally renownedprogramme is open to doctorsand physiotherapists. Theprogramme is based on thephilosophy of total care for theathlete and the promotion ofphysical activity in the generalpopulation. It is unique in the UK for the delivery of integratedacademic and practical tuition.Based on the main Mile EndCampus, the maximum intake is30 students.

Working in sport is a largelypractical discipline and theemphasis on the programme is for regular clinical experience.Programme participants benefitfrom regular contact withmembers of the Centre as well as visiting clinicians and lecturerswho are experienced sportmedicine specialists. The Centreis ideally situated on the samecampus as the sports injury,physiotherapy, podiatry and theinterdisciplinary combined sportsclinics. Additionally you will havethe opportunity to attendrecognised external clinics aroundLondon, as well as the chance toattend sporting events and visitsto national centres of excellencewhere possible.

Many of our alumni now work inboth professional and amateursport, 14 worked at Athens 2004Olympic Games, and the Centrewas involved for the bid forLondon 2012 Olympic Games.

Programme outline MScEight taught modules plus aresearch project (equivalent to four modules)

Postgraduate DiplomaEight taught modules

• Semester 1: September –December (12 weeks) fivemodules available

• Semester 2: January – March(12 weeks) five modulesavailable

• MSc Research project:December – September Clinics:compulsory attendance of 32clinics

ModulesSports Injury Assessment I •Sports Injury Assessment II •Sports Injury Treatment • SportsInjury Rehabilitation • Exercise as a Health Tool • Podiatry andBiomechanics • MedicalProblems in Sport • ExercisePhysiology and Team Medicine •Injection of the Spine andAppendicular Skeleton •Research Methods

Assessment Taught modules are assessed by a variety of written exams,coursework and clinical exams. All are weighted in varying

degrees, the dissertation accountsfor one third of the total marks.

Entry requirementsDoctors and physiotherapists withat least one year’s postgraduaterelevant clinical experience.Current involvement with sportwould be an advantage.Physiotherapists with overseasqualifications must be registeredwith the Health ProfessionsCouncil.


Further informationDr Peter MalliarasTel: +44 (0)20 8223 8255email: [email protected]/sportsmed

William HarveyResearch Institute


William Harvey Research Institutewww.whri.qmul.ac.uk

Director of InstituteProfessor Mark Caulfieldemail: [email protected]

Director of Graduate StudiesDr Martin Carrieremail: [email protected]

Key research areasThe William Harvey ResearchInstitute has just celebrated itstwenty-fifth year with real successand growth in the depth andquality of our programmes incardiovascular, inflammation andendocrine research. Our majorstrength is in bringing scientistswith different skills together. Ourgoal is to combine disciplines,such as genetics, cell biology,pharmacology, epidemiology,advanced imaging and clinicaltrials, with therapeutic innovation.Recently we have strategicallyinvested over £4.1 million inexcellent researchers to supportour mission and increased staff by24 per cent.

This Institute was established bythe Nobel Laureate Sir John Vanein 1985, and is named afterWilliam Harvey who revolutionisedmedicine by the discovery of thecirculation of blood. The coreaims of the research in theinstitute are: to study the causes,mechanisms and therapy ofendocrine disease; to advanceknowledge as a basis for theidentification of new therapies toprevent heart and vascular andinflammatory disease and to treatrheumatoid arthritis, renal diseaseand the many complications ofdiabetes.

Our new state-of-the-artlaboratories host seven distinctcentres:

• ARC Bone and Joint Research Unit

• Biochemical Pharmacology

• Clinical Pharmacology

• Endocrinology

• Experimental Medicine and Rheumatology

• Microvascular Research

• Translational Medicine and Therapeutics

The Centres are organised in aflexible manner so as to promote,and assure maximal interactionand cross-fertilisation. We foreseethat the future of modernbiomedical science will inevitablyprogress through exchange ofideas, tools, models and systemsand benefit from teamwork and amulti-disciplinary approach. Thephysical structures of thelaboratories, complemented bythe shared interests across thecentres, guarantee theimplementation of this vision.

The aim of the centres is to createan integrated and focusedPharmacological Research Groupbased at the CharterhouseCampus. The research strategy isto fully integrate the basic andclinical research. The aim is todevelop the largest centre forheart disease research in Europe,and to develop a cardiovascularresearch centre that willcomplement the plannedcoalescence of clinical cardiac

services at St Bartholomew’sHospital. Similarly the AcademicDepartment of Rheumatologyinterlinks with the clinical serviceand supervises the widely praisedSPR training programmes. This isfurther enhanced by the clinicalresearch programmes, enablinglinks between the clinicaldepartment and Centres withinthe Charterhouse campus, andwith other researchers within theInflammation Research theme.These key clinical partnershipsensure our scientists remainstrongly connected to the patientand the disease process. Inaddition a brand new 3000m2,£14 million heart research centreis due to open later in 2010.

ARC Bone and Joint Research UnitThis Unit consists of amultidisciplinary faculty ofscientists and clinicians interestedin the basic molecularmechanisms of autoimmunediseases and connectivedisorders, including rheumatoidarthritis and systemic lupuserythematosus. Research in theUnit is aimed at developing newgene therapy tools andapproaches with stem cells fordelivering therapeutics and repairsites of chronic disease, with amajor, but not exclusive, attentionto the rheumatic joint, and todevelop gene delivery methods for treatment.

Other research activities include:signalling cascades in T cells andthe molecules that are found onlipid rafts and how this surface


William Harvey Research Institute

membrane localisation affects cellfunction; research devoted tounderstanding the role that Blymphocytes play in systemiclupus erythematosus and otherrheumatic diseases; using phagedisplay technology, humanmonoclonal antibodies have beendeveloped that specifically bind toarthritic cartilage and can be usedfor targeting therapeutic agents orcells only to arthritic joints.

A wide range of possibletherapeutic targets is beinginvestigated. Work in the grouphas already demonstrated atherapeutic effect of interferon ina model of rheumatoid arthritis.

Biochemical PharmacologyCentreThe research emphasis here is on the control of inflammatoryand immune diseases andmechanisms of immuno-modulatory and anti-inflammatorydrug action (such as Cox-2inhibitors and glucocorticoids). Of particular interest to the Centreare the nature and function ofendogenous regulators thatmitigate and control theinflammatory response and(normally) bring about its timelyresolution. We have pioneered the notion that malfunction ofendogenous counter-regulatorypathways may precipitate orprolong inflammation and that itmay be a causal factor in chronichuman inflammatory disease isbeing actively investigated.

We seek to generate novel drugsbasing targets on the properties of

such counter-regulatory factors.Work in this group has alsodefined the role of the proteinannexin A1 in inflammation andother disorders; research hasshown that it acts to regulate theflux of leucocytes duringinflammation.

The Centre utilises techniquesspanning in vivo and in vitroapproaches including molecularbiology, transgenic models,experimental pathology, cellbiology and human pharmacologyof anti-inflammatories.

Centre for ExperimentalMedicine and RheumatologyResearch activities focus on the development of innovativetherapeutic and diagnosticapproaches to inflammatoryarthropathies, particularlyrheumatoid arthritis. Thus,research goals in this Centre is infull synergy with that of the ARCBone and Joint Unit andBiochemical Pharmacology,contributing to an overall criticalmass of 80 clinicians andscientists dedicated toinflammation research,regenerative medicine, andrheumatology.

The emphasis is on translationalresearch by combining strengthsand expertise of basic andclinician scientists, The mainresearch themes include:Molecular mechanisms of tissuespecific homing, chemokines andcytokines in cell migration andjoint damage; the pathobiology ofsynovitis: relationship to clinical

phenotypes, biological anddisease outcomes. Why do only aproportion of patients that presentearly inflammatory arthritis carryon developing rheumatoidarthritis; target discovery, drugdelivery, imaging and proof ofconcept/efficacy studies usingplatform technologies based onphage display and thehuman/SCID mousetransplantation model, biologicaljoint tissue repair developingmolecular and stem cell basedtherapies for joint tissue repair.

The development of a qualitycontrolled cellular product for cell-based joint surface repair(currently being tested in a phase3, multicentre randomised clinicaltrial) is a major result. Thisresearch programme merges wellwith other on-going high qualityresearch projects on Stem Cells of our Medical School.

Centre for TranslationalMedicine and TherapeuticsThe Centre for TranslationalMedicine and Therapeutics wascreated by merging three distinctunits. This Centre reflects the newspirit pervading the WHRI, andthe strong commitment to sharingfacilities, ideas and researchprojects, with synergisticoutcomes. Common researchthemes evolve around vascularbiology, endothelial dysfunctionand preservation or restoration oforgan integrity. More specificallythe centre aims to: Develop novelapproaches for the therapy ofmyocardial infarction, acute andchronic renal failure and shock; tounderstand the ways in which


both endothelial and vascularsmooth muscle cell functionswithin the blood vessel changefollowing exposure to pro-inflammatory stimuli such ascytokines and free radicals. Thecentre also has a major interest inthe experimental and clinicaldevelopment of biomarkers thatcould become novel diagnostictools. Techniques spanning fromcomplex in vivo protocols to invitro approaches includingmolecular biology, transgenicmodels, cell biology and humanpharmacology to clinical trials.

Centre for Clinical PharmacologyThe William Harvey ResearchInstitute offers one of the largestCentres for Clinical Pharmacologyin the UK. Our research strategycombines basic science; rangingfrom vascular biology, genomicapproaches and large-scalegenetic epidemiology to innovativeclinical trials as a route topotential new therapies forcardiovascular disease, preventionof transplant rejection and painmanagement.

The major research themes aresummarised below:

Molecular genetics ofcardiovascular disease, fromClinical Pharmacology we co-ordinate the MRC British Geneticsof Hypertension (BRIGHT) Studyon behalf of five other UKuniversities. This collaborativeprogramme has assembled a highquality repository for theinvestigation of the genetic basisof hypertension. Other studiesinclude Genetics of pre-eclampsia

and the biological atlas of insulinresistance. As genetic studies arebeginning to progress to anintegrative biology approach weare developing a strong interest in Proteomic Medicine to facilitatedevelopment of cardiovascularproteomics and metabonomics.

Identification of positional andfunctional candidate genes forcoronary artery disease; animportant observation being onthe role of genes encoding matrixmetalloproteinases inatherosclerosis.

A further major area of interest isresearch into new mechanismsunderlying the protective actionsof the endothelium; whichincludes nitric oxide and

endothelium derivedhyperpolarising factor.

Centre for MicrovascularResearchThe overall research objectives of this centre are to investigatemolecular and cellular eventswithin the microvasculature,focusing on mechanismsassociated with leukocytetrafficking, vascular permeabilityand regulation of vascularintegrity, morphology andfunction, in vivo. The principalapproach employed is that ofcutting edge imagingmethodologies, in particular real-time imaging of themicrocirculation using fluorescentand confocal microscopy.


William Harvey Research Institute

Centre for EndocrinologyThe group’s research isunderpinned by an internationallyrenowned expertise in adult andpaediatric clinical endocrinology.Research activity in this Centrespans the range between clinicallyapplied research in endocrinologyto basic research in endocrinesignalling pathways. Clinicalresearch benefits from theextensive clinical endocrinologyexperience and the national andinternational referral practice forcomplex endocrine disorders thathas accumulated in over fortyyears as the UK’s foremost clinicalendocrinology unit. Endocrinologyresearch benefits fromconsiderable cross-fertilisationbetween clinical and laboratoryresearch components.

Molecular EndocrinologyResearch themes include growthdisorders in infancy andchildhood. This theme builds onthe extensive clinical practice inthe diagnosis and management ofgrowth hormone (GH) insensitivitywhich has led to identification ofseveral novel geneticmechanisms; studies into thebiological function of the peptideghrelin and in particular its role ingrowth and obesity; mechanism ofACTH action via the ACTHreceptor and its disturbance inACTH insensitivity; molecularbasis of pituitary and otherneuroendocrine tumour formation,building on longstanding clinicalexperience of the diagnosis andmanagement of these tumours;mechanisms regulating gene

expression in pituitarygonadotroph, bone and othercells.

Recent research exploits modernmolecular and cell biologicaltechnology to investigate aspectsof functional physiologicalgenomics and genetics as appliedto the hormone producing andhormone sensitive tissues.

Clinical EndocrinologyAs the largest centre for clinicalendocrinology in the UnitedKingdom, a wealth of clinical dataand expertise supports researchin several areas. It has been atthe forefront internationally interms of the assessment of newdiagnostic and treatmentmodalities in endocrinologygenerally, and more specifically inneuroendocrinolgy and endocrineoncology. More recently, clinicalinvestigation has centred on thevalue and effects of GH deficiencyin pituitary disease, and we haveone of the largest groups ofpatients in the world on GHreplacement therapy. On-goingprotocols include assessments of novel types of testosteronereplacement therapy, anassessment of the optimaldiagnostic strategies for Conn'ssyndrome andhyperparathyroidism, the use ofsomatostatin analogues in non-functioning neureoendocrinemaligancy, and the treatment ofosteoporosis in Cushing's disease.Many of these studies are initiated‘in-house’, but we have anestablished expanding portfolio of

studies in collaboration with thepharmaceutical industry. We haveaccess to all the latest assays anddiagnostic ‘hardware’, but mostimportantly our ever-expandingpatient base is now trulyinternational. We have adedicated and fully staffedinvestigation unit with 16 in-patient beds available for thestudy and treatment of all types of endocrine disease.

Barts and The London GenomeCentreThis is a state-of-the-art highthroughput genome centreembedded within the WilliamHarvey Research Institute. TheCentre provides technologies tosupport scientists, which includewhole genome gene expressionservice, fully automatedquantitative gene expressionservice, SNP genotyping, DNAsequencing from PCR andPlasmid templates and automatedDNA quantification.

Barts and The London MassSpectrometry UnitThis facility offer state-of-the-artMALDI-TOF and LC-MS/MSinstruments for a wide range ofprotein analyses. These includeprotein identification from 1D or2D gels, identification of post-translational modifications such as phosphorylation anddetermination of intact proteinmass.

The Unit provides support forcollaborative research and we arecurrently working with researchers


in cardiovascular disease researchprojects including hypertension,left ventricular hypertrophy andendothelial dysfunction, as well as other research areas such asfertility and cancer.

The William Harvey ResearchFoundationThe William Harvey ResearchFoundation (WHRF) has been a member of the Association ofMedical Research Charities since1990. The Foundation supportsresearch primarily in the WHRI.The Foundation also plays a keyrole in funding the training ofyoung medical researchersthrough PhD and Masters ofResearch Studentships.

William Harvey Research LimitedWilliam Harvey Research Limitedwas established in 1990 tofacilitate interaction between

academia and the pharmaceuticalindustry. Scientific personnel ofthe WHRI provide the foundationof experience and expertise tocomplement drug developmentfor pharmaceutical and biotechcompanies.

Opportunities at WHRIWHRI Research Graduate Studies TrainingThe Institute provides a widerange of PhD, MD (Res) andMasters training under theauspices of the Graduate School.More information can be obtainedby contacting the PostgraduateResearch Tutor who will ensureyour request is appropriately dealtwith.

WHRI Mentoring, Tenure trackOur approach to mentoringclinicians and scientists includesstrong encouragement for peopleto recognise when their research

training would benefit from a period in another researchinstitution so they may accruenew strengths and to return tosenior positions if they wish in the future. This approach whichinitiated the careers of most of theWHRI Principal Investigators isstill very active.

Clinical Academic careerdevelopmentThe WHRI is committed todeveloping high cadre nationaland international clinicalresearchers and we are closelyengaged through academicclinicians to cardiology,nephrology, endocrinology andrheumatology in our allied NHSTrust. We actively encourage andsupport undergraduate andpostgraduate clinicians to engagein our research projects andgarner pilot data for fellowshipapplications.

William Harvey Annual Research ReviewThe WHRI believes inencouraging and investing inpeople who will contribute hereand elsewhere to internationalquality research. As part of thisstrategy we hold the WilliamHarvey Annual Research Reviewwhere the strategic direction ofthe School and Institute isarticulated by senior academicstaff, but the majority of time is formore junior researchers and PhDstudents to showcase theirresearch. The William Harveyholds weekly seminars by nationaland international experts.


Senior staff research interestsWilliam Harvey Research Institute

Amrita Ahluwalia BSc PhDProfessor of VascularPharmacologyProfessor Ahluwalia's workfocuses on mechanisms ofvascular homeostasis ininflammation and particularly therole of the endothelium, also inthe identification of novelmediators protecting againstvascular dysfunction.Endothelium-derived vasodilators

including nitric oxide, prostacyclinand endothelium-derivedhyperpolarising factor (EDHF) playa key role in these processes.Professor Ahluwalia’s recent workhas further highlighted theimportance of these mediatorsand mechanisms whichcoordinate their bioactivity tooptimise the cytoprotective effectsof the endothelium. In particularher studies have provided further

insight into the gender difference(together with Dr RamonaScotland) in cardiovasculardisease, with EDHF appearing to play a prominent role inconferring a cytoprotectivephenotype in females, an effectlikely mediated by oestrogen. In a separate study we have shownthat eNOS can act in both a pro-and anti- inflammatory mannerand therefore is likely to be pivotalin the initiation and timecourse ofan inflammatory response,particularly with respect toinflammatory cardiovasculardisorders such as sepsis. Otherrecent work has identified theacute blood pressure lowering,vasoprotective, and antiplateletproperties of dietary nitrate.

Jacky Burrin BSc PhD FRCPathProfessor of ExperimentalEndocrinologyProfessor Burrin’s main researchinterests focus on the hormonalregulation of gene expression,particularly investigation of therole of transcription factors (SF-1,DAX-1, GATA) in thedifferentiation of pituitary celltypes and peptide-regulatedhormone gene transcription andtheir relevance to pituitary tumourpathogenesis. The role of BMPs in this system is currently underinvestigation (funded by theBBSRC). This work links withresearch into nuclear hormonereceptors (LXR and PPARs)mediating BMP actions

on osteoblast differentiation andthe role of glucocorticoids ininhibition of osteoblastproliferation. Investigation of the


signal transduction pathwaysinvolved in both systems,particularly MAPK signalling, is integral to this research.

Mark Caulfield MB BS MD FRCPProfessor of ClinicalPharmacology, Institute Directorand Centre lead ClinicalPharmacologyMark Caulfield graduated inMedicine in 1984 from TheLondon Hospital Medical College and trained in ClinicalPharmacology at StBartholomew’s Hospital where hedeveloped a research programmein molecular genetics ofhypertension. From 1996 he hasbeen National Co-ordinator of theMRC British Genetics ofHypertension (BRIGHT) Study on behalf of five UK Universitieswww.brightstudy.ac.uk. Ourpurpose-built clinical researchfacility the William HarveyResearch Institute played a keypart in the Anglo-ScandinavianCardiac Outcome Trial recruiting1,157 hypertensives(www.ascotstudy.org.uk). This trial has changed internationalguidance on lipid lowering andblood pressure. In 2000 hesuccessfully bid for £3.1 million to create the Barts and TheLondon Genome Centre, whichnow underpins over 40programmes of research. He was appointed Director of WilliamHarvey Research Institute in2002.

Other current research interestsinclude: Principal investigator ofthe Genetics of Pre-eclampsia

Consortium – which has identified1,000 families with pregnancy-related hypertension for geneticstudies; Co-grant holders withImperial, Cambridge and Oxfordfor the Biological Atlas of InsulinResistance to developobservations on metabolicsyndrome and translate thesefrom experimental models to man;Deputy Chair, The LondonBiobank regional collaboratingcentre, Chair of Biobank UKethnicity sub-group and amember of Biobank UKmeasurement sub-group.

Yuti Chernajovsky BSc MSc PhD ARC Professor of Rheumatology,Centre Lead of the Bone and JointResearch Unit

Professor Chernajovsky trained as a molecular biologist at TheWeizmann Institute of Science inIsrael. His research activities haveincluded the cloning of severalinterferons, interleukins and theirreceptors. He has contributed tothe cloning and development ofinterferon beta as a therapeuticagent and the use of suicidalgenes for cancer gene therapy.Current research interests includethe development of gene transferstrategies for the treatment ofrheumatoid arthritis via cellularengineering, molecular designand genetic engineering. He is amember of the editorial boards of the British Journal ofPharmacology, Gene Therapyand Arthritis Research andTherapy.

Shern Chew BSc MB BChir MDFRCP Professor of Endocrine MedicineDr Chew’s research investigatesthe mechanisms of regulation ofpre-mRNA splicing with clinicalresearch in clinical endocrinology.This research is funded byfellowships from the WellcomeTrust.

Adrian Clark DSc FRCP FMedSciProfessor of Medicine, CentreLead EndocrinologyProfessor Clark’s major researchfocus is on the molecular basis ofthe action of the pituitaryhormone ACTH and its role in thepituitary-adrenal axis in healthand disease. The group havedemonstrated the role of ACTHreceptor defects in inheritedsyndromes of ACTH insensitivitywhich have led to a detailedinvestigation of the functionalbiology of this receptor. Defects in a newly discovered gene thatappears to function as a receptorchaperone have recently beendescribed, providing major newinsights into receptor function. Inaddition, a longstanding interest in growth hormone insensitivity inconjunction with Professor MartinSavage has resulted in theidentification of several growthhormone receptor mutations thatlead to novel mechanisms ofreceptor impairment, and to theonly human case of IGF-I genedeletion. A prospective study ofmultiple candidate genes inaffected patient-parent trios isbeing pursued in the NESTEGGstudy, a large cross-Europeancollaborative programme. A



further interest focusesspecifically on mechanisms thatlead to hypertension and insulinresistance.

Roger Corder BSc MSc PhDMRPharmSProfessor of ExperimentalTherapeuticsProfessor Corder’s main researchinterests are the links betweendiabetes and atherosclerosis. Thisresearch has essentially two goals.Firstly, to discover newtherapeutic approaches that canbe used to prevent this ever-increasing health problem.Secondly, to identify biomarkers ofdisease, which can be used in theearly diagnosis of patients beforesymptoms of disease becomeapparent. These interests havealso led him to investigate theimportance of improving healthand cardiovascular well-beingthrough diet. During the past fiveyears he has studied themechanisms underlying thebeneficial effects of regular redwine consumption. He is alsopursuing research on alternativesto wine, such as grape seedextract, as these are moreamenable to conducting clinicaltrials. This research is providing awealth of new insights into howpolyphenol-rich diets can modifyvascular well-being. ProfessorCorder is currently supervisingstudents investigating themechanism of action ofpolyphenols on vascular function,biomarkers of vascular disease indiabetes, and regulation ofgluconeogenesis in type 2diabetes.

Rod Flower FRS BSc PhD DSc Professor of BiochemicalPharmacology and joint CentreLead, Biochemical PharmacologyRod Flower is a Wellcome TrustPrincipal Fellow and Professor of Biochemical Pharmacology.Throughout his life he hasresearched the mechanisms ofanti-inflammatory drugs and has a particular interest in NSAIDsand glucocorticoids.

His current interests include thepharmacology of annexin 1 andits relationship to glucocorticoidaction in host defence and theneuroendocrine system. RodFlower was formerly President of the British PharmacologicalSociety and is a Fellow of theAcademy of Medical Sciences andThe Royal Society.

Ashley Grossman BA BSc MDFRCP FMedSciProfessor of NeuroendocrinologyIn addition to clinical work in neuroendocrinology andendocrine oncology, ProfessorGrossman runs a research groupin translational research. Hismajor clinical interest is inoptimising diagnostic techniquesand therapeutic modalities inpituitary and neuroendocrinetumours. His major basic researchover the past years has been intothe hypothalamic control ofpituitary function, and particularlythe role of cytokines and gaseousneurotransmitters in regulating thepituitary-adrenal axis. Morerecently, he has focused on themolecular pathogenesis ofpituitary tumours, specifically on

abnormalities in cell cycle and cellsignalling pathways, usingpathological human material andas well as cell culture techniques.Much of this work has beencarried out in collaboration with Dr Márta Korbonits, andincreasingly the control ofmetabolic processes by ghrelinand related peptides has beenshown to interact with theregulation of cell proliferation.

Charles Hinds FRCP FRCAProfessor of ExperimentalMedicineProfessor Hinds is a pastPresident of the Intensive CareSociety and until recently wasChairman of Examiners for the UKDiploma of Intensive Care. He isUK representative on the Councilof the European Society ofIntensive Care Medicine, amember of the Education andTraining Subcommittee of theESICM and UK co-ordinator forthe European Diploma of IntensiveCare Medicine. Professor Hinds’research interests have includedthe pathophysiology andtreatment of sepsis, ‘goal directed’therapy, endocrine aspects ofcritical illness, critical illnesspolyneuromyopathy and intensivecare for patients with malignancy.More recently he has developedan interest in the genomics

of sepsis and has helped toestablish the UK Critical CareGenomics Group which isundertaking a large Nationalinvestigation (GAinS –www.ukccg-gains.org), as well asbeing National co-ordinator for


the European ‘GenOSept’ study(www.esicm.org). Other currentresearch interests include the use of a nitric oxide generatingmixture to prevent ventilatorassociated pneumonia and peri-operative optimisation for patientsundergoing high risk surgery.

Paul Jenkins MA BChir MD FRCPReader in Endocrine OncologyDr Jenkins’ research has centredon understanding the influence ofgrowth hormone and insulin-likegrowth factor-I (IGF-I) on thebowel and in particular their rolein colorectal cancer. This hasbeen facilitated by the study ofpatients with acromegaly, of whichmore than 400 are looked after bythis Department. Recent researchhas confirmed that these patientsare at increased risk of developingcolonic polyps and cancer, and isbeing undertaken to understandthe mechanisms by which thismight occur. The work will spanthe investigation of basicmolecular pathways to theirinvolvement in the clinicalsituation with the eventual aimbeing to modify these and thusalter clinical care. The other majorarea of interest is growth hormoneand exercise and the detection ofgrowth hormone doping byathletes, which is an area ofincreasing concern to sportsgoverning authorities.

Staff profile: Sussan NourshaghProfessor of MicrovascularPharmacologyCentre for MicrovascularResearch

‘‘

‘‘I was appointed Professor ofMicrovascular Pharmacology atthe William Harvey ResearchInstitute to head a new Centrefocusing on MicrovascularResearch. My research groupfocuses on the mechanisms ofleukocyte trafficking into sites of inflammation and theconsequence of this responseon regulating the phenotype of emigrated cells.

The group’s principal experimental approach is the use of advancedimaging techniques (eg intravital and confocal microscopy) foranalysis of leukocyte/vessel wall interaction in vivo. Our work issupported by The Wellcome Trust, The British Heart Foundation andfunds from the EU and has been published in high ranking journalssuch as Journal of Immunology, Blood, Journal of ExperimentalMedicine, Nature Reviews and Science.

My PhD project addressed mechanisms of neutrophil activation in vitro, and I extended my interests in this area to the in vivoinflammatory scenario through post-doctoral work at the MRCClinical Research Centre based in Harrow, and then at the NationalHeart & Lung Institute (NHLI) in London where I was appointed toLecturer position in 1988.

In 2001, I was awarded the Quintiles Prize for outstandingcontribution to Immunopharmacology and became Fellow of theBritish Pharmacological Society in 2005. I have acted as acommittee member on the British Heart Foundation Project Grantpanel (2002-2006), was a co-founder and committee member ofthe London Vascular Biology Forum (2001-2008) and am currentlythe Treasurer of the UK Adhesion Society and Programme &Fellowship Committee member for the American Society ofInvestigative Pathology (ASIP).



Atholl Johnston BSc MSc PhDFBPharmacolS FRCPathProfessor of ClinicalPharmacologyProfessor Johnston has over 30 years experience in themeasurement of drugconcentrations as a guide totherapy and in relation to toxicity.His research interests are inclinical trial design and statisticaldata analysis, modellingpharmacokinetics andpharmacodynamics, and inoptimal use ofimmunosuppressive,cardiovascular, analgesic and anti-cancer drugs. Potentialmechanisms for these differenceshave been explored further bydetailed examinations of thepharmacogenetics determinantsof the metabolism ofimmunosuppressant drugs.Professor Johnston has

contributed to internationalconsensus papers on the optimaluse of ciclosporin in psoriasis,ciclosporin monitoring, ciclosporingeneric substitution and itspotential impact on transplantoutcome. Professor Johnston has a commitment to continuingeducation. He has alreadyinitiated Masters courses inclinical drug development and in healthcare research and withProfessor Peter Vanezis hasdeveloped a modular course inforensic medical sciences.

Márta Korbonits MD PhD Professor of Endocrinology and MetabolismProfessor Korbonits studies thehormonal regulation of the cellularenergy sensor AMP-dependentprotein kinase (AMPK) inparticular regarding ghrelin andcannabinoids. Her current interest

in pituitary disease is focused onfamilial pituitary adenomas. Keyobjectives are: Ghrelin andcannabinoids stimulatehypothalamic and heart AMPKactivity but in contrast, they inhibitAMPK activity in liver and adiposetissue. Ghrelin and cannabinoidpathways are potential targets forobesity treatment. We have showna direct interaction betweenghrelin and cannabinoids. Furtherinvestigations of the relationshipwill improve the understanding of the underlying mechanism ofenergy homeostasis; Familialpituitary adenomas are rare butincreasingly recognised. ProfessorKorbonits in collaboration with UKand international colleagues hascollected a large cohort of familialpituitary adenoma families andstudies the clinical characteristicsas well as the genetic andfunctional basis of the alterations


of the gene, the AIP gene,mutated in a significant minorityof this cohort. She is workingclosely with Professor Grossmanin topics related to cell cycleregulation and endocrinetumorigenesis especially in thepituitary gland.

Richard Langford MB BS MRCSLRCP FRCAProfessor of Inflammation ScienceProfessor Langford’s currentresearch interests include acuteand chronic pain studies. He hasestablished the Pain ResearchGroup, which now has eleven full-time research staff conductingclinical trials; development andevaluation of patient monitoringdevices, including opto-electricalphotoplethysmography, and depthof anaesthesia / cerebralmonitoring during surgery andintensive care.

Rizgar Mageed BPharm PhD Professor of ExperimentalImmunologyProfessor Mageed’s interests arefocused on defining the cellularand genetic factors that underliethe development of immune-mediated diseases. Early studiesexamined the genetic basis thatunderpins defective lymphocyteactivity leading to the productionof pathogenic autoantibodies inpatients with chronic inflammatorydiseases such as rheumatoidarthritis (RA) and systemic lupuserythematosus (SLE). Thesestudies have indicated thatlymphocytes from patients withRA and SLE are inherently hyperactive. Current studies are

aimed at defining the preciseintracellular biochemical signallingdefects that cause lymphocytehyper activity includingdysregulated responses to selfantigens. These studies willprovide insights into howlymphocytes are regulated andhow intracellular biochemicalsignalling pathways determinewhether there is homeostasis orautoimmune disease. Some of thisdata is being used to design newtherapeutic targets by genetherapy. Professor Mageed haspublished numerous scientificpapers on the molecular basis of susceptibility to RA and SLE.

Anthony Mathur MA MB BChirMRCP PhDSenior Lecturer and ConsultantCardiologistDr Mathur divides his time equallybetween clinical work and basicscience with the aim ofconducting translational research.Key interests are directed atunderstanding the role of celltherapy in the treatment ofcardiovascular disease. Thiscovers a broad spectrum ofresearch ranging from a study of the mechanism by which celltherapy may improve cardiacfunction to optimisation of celltherapies to ultimately producecardiac regeneration. Clinicalresearch is directed at newtreatments for the 'no-option'patient - that is people who havecardiac disease and no furtherconventional treatments availableto treat on-going symptoms. DrMathur is the chief investigator ofone of the largest clinical trials to

date looking at the role of stemcells in cardiac repair for patientswith heart failure.

Patricia Munroe BSc MSc PhDProfessor of Molecular MedicineProfessor Munroe’s research is focused on determining themolecular basis of essentialhypertension. With Professor MarkCaulfield, she co-ordinates theBritish Genetics of Hypertension(BRIGHT) study on behalf of fiveother UK universities (Aberdeen,Cambridge, Glasgow, Leicesterand Oxford).

Sussan Nourshargh PhDFBPharmacolSProfessor of MicrovascularPharmacologyProfessor Nourshargh’s interestsare in the mechanisms ofleukocyte trafficking into sites of inflammation and theconsequence of this response on regulating the phenotype of emigrated cells. Her keyobjectives include: Dissecting themolecular and cellular interactionsthat mediate leukocytetransmigration through venularwalls, investigating themechanisms associated withleukocyte emigration throughendothelial cells, pericytes andthe EC basement membrane.Analyse and characterise theconsequences of leukocytetransmigration on regulation ofexpression of effector moleculesand regulation of leukocyteresponsiveness under differentinflammatory scenarios.Mechanisms of leukocytetransmigration in specific disease



models, to investigate the abovefundamental phenomena in bothphysiological inflammatoryscenarios and experimentalmodels of disease, such asmodels of ischemia/reperfusioninjury and vasculitis.

David Perrett BSc PhD FRSCCChemProfessor of Bioanalytical ScienceResearch interests extend tomany biomedical aspects ofseparation science having beenone of the first researchers inBritain to develop and use HPLC(1972). Since 1989 bioanalyticalresearch interests have includedextensive studies on theapplication of capillaryelectrophoresis (CE) to biologicaland clinical samples. Currentinterests extend these olderinterests into proteomics,metabolomics and mass

spectrometry. Research interestsinclude clinical proteomics, freeradical damage to proteins andmultidimensional chromatography.Much current research workrelates to the decontamination ofsurgical instruments in relation tovCJD. In 2002 he was awardedthe Jubilee Medal of theChromatographic Society cited forthe Development of SeparationScience in Biomedicine andClinical Chemistry. He is anelected member of the Council ofAnalytical Division of the RSC, theCouncil of the British Society ofProteome Research. He has alsochaired the Techniques Group ofthe Biochemical Society and theChromatography andElectrophoresis Group of the RSC.He serves on two Department ofHealth committees ondecontamination.

Mauro Perretti BSc MSc PhDFBPharmacolSProfessor ofImmunopharmacology, SeniorResearch Fellow of the ArthritisResearch Campaign, joint CentreLead Biochemical PharmacologyProfessor Perretti’s work focuseson the investigation of theendogenous mediators thatactively promote resolution ofinflammation and regain of tissuehomeostasis. To regain health after aninflammatory insult, the host mustorganise a proper inflammatoryresponse, which however, shouldresult from an appropriatetemporal and spatial balancebetween endogenous pro-inflammatory and anti-inflammatory mediators andpathways. The group studiesspecific elements of thisendogenous response, focusingon selected mediators andreceptors. Therefore, on one handthe patho-physiological relevanceof these mediators in models ofacute (air-pouch, peritonitis) andchronic inflammation (eg arthritis,endotoxaemia) is determinedusing a combination of molecular,cellular and integrate biologyapproaches (eg transgenic tools);on the other hand, an equallyimportant ethos of this research isthe identification of the target(s)mediating the effects ofendogenous anti-inflammation as a lead for innovative drugdiscovery: these new therapeuticswill potentially produce much lessside effects, since they will bemimicking the way our bodynaturally controls theinflammatory reaction.


Costantino Pitzalis MD PhDMRCPProfessor of ExperimentalMedicine and Rheumatology,Centre lead ExperimentalMedicine and RheumatologyProfessor Pitzalis’s main researchactivities focus on thedevelopment of innovativetherapeutic and diagnosticapproaches to inflammatory and degenerative arthropathies,particularly rheumatoid and osteo-arthritis. Specific research areasinclude: Molecular mechanisms of tissue specific homing,chemokines and cytokines in cell migration and joint damage.Applying a phage displaytechnology to the SCID model we have identified novel peptidesequences endowed with specifichoming to human rheumatoidsynovium. We are also exploitingthe use of these sequences fordeveloping tissue-specific imagingand drug delivery systems,thereby targeting anti-rheumaticdrugs as well as new treatmentsto the joint: The pathobiology ofsynovitis and the relationship toclinical phenotypes, biological and disease outcomes. This is animportant area of research withthe likelihood of high translationalimpact. This programme aims tocharacterise clinical phenotypespathobiologically in order toidentify markers that can tailoraggressive treatment to patientswith poor prognosis therebyimproving longitudinal diseaseoutcomes. We have developed a chimeric model in which cellhoming to human tissuetransplanted onto SCID mice can

be studied, both for pathwaycharacterisation (eg traffickingmechanisms), target identification(eg specific chemokine receptors)as well as dissecting immune-inflammatory pathogeneticmechanisms for novel therapeuticdevelopment. The latter aspect isextremely important and novel,since it enables us to investigatethe efficacy of potentialtherapeutics on human cells and human tissues (for examplerheumatoid synovium) such thatdrug effectiveness is likely to havetranslational value.

Martin Savage MA MB FRCPFRCPCHUnit head and Professor ofPaediatric EndocrinologyThe principal interests of the unitare; the molecular and endocrinecharacterisation of disorders ofthe GH-IGF-I axis, treatment ofGH resistance with therecombinant IGF-I/IGFBP-3complex, growth genetics and the investigation and treatment ofpaediatric Cushing’s syndrome.There is close collaboration withProfessor Adrian Clark’slaboratory, where identification ofseveral new mutations of the GH-IGF-I axis have beendemonstrated. We are currentlyco-ordinating a pivotal therapeutictrial of the recombinant IGF-I-IGFBP-3 complex (Insmed Inc) in patients with GH insensitivitysyndrome. The NESTEGG project(Network for the study of genes in growth) is directed by AdrianClark and co-ordinated by LindaJohnston. This project, whichunites populations of short stature

patients from London, Rotterdam,Toulouse and Tübingen, will studycandidate genes for linkage ofSNPs with phenotypic variants in idiopathic short stature andchildren born SGA. We currentlyhave a database of 46 patientswith paediatric Cushing’ssyndrome. Patients are referredfrom the UK, Europe and beyond.Characteristics of 30 patients withCushing’s disease have beenrecently published. We collaborateclosely with the Department ofAdult Endocrinology,Neurosurgery and Radiotherapy.

Ken Suzuki MD PhDProfessor of TranslationalCardiovascular TherapeuticsProfessor Suzuki has aninternational reputation incardiovascular stem cell and genetherapy research. His extensiveexpertise will strongly complementour on-going clinical programmeat Barts and The London (led byDr Anthony Mathur and ProfessorMartin Rothman) to evaluate anemerging strategy using adultstem cells for treating heartdiseases and thus significantlycontributing to the establishmentof a Centre of Excellence inclinical stem cell research whichis underpinned by strong basicscience programmes. Hisresearch approach acknowledgesthat the success of clinical trials of cell therapy critically depend on resolving several fundamentalissues by further laboratoryresearch. His researchprogramme has focused uponvarious aspects of behaviour of grafted cells in a cardiac



environment and interactionbetween native and grafted cellsat genetic, molecular and cellularlevels. Suzuki is now focusing onstudying, and therapeuticallycontrolling arrhythmias after celltherapy. Current research projectsevolves around the study ofcardiac side population cells,transendothelial migration ofdonor cells into the myocardialinterstitium and the role ofinflammatory response in celltherapy-mediated therapeuticeffect, the latter clearly ofpotential synergy with other labsof our Institute.

Chris Thiemermann MD PhDFBPharmacolS FMedSciProfessor of Pharmacology, Centrelead Translational Medicine andTherapeuticsProfessor Thiemermann is aleading expert in thepathophysiology and therapy ofmyocardial infarction, renal failureand shock. He holds VisitingProfessorships in Pharmacologyand Medicine at the Universitiesof Florence, Oslo, Messina,Vienna and Singapore. He iscurrently a Fellow of the Academyof Medical Sciences of the UnitedKingdom, a Foreign Member ofthe Academy of Sciences ofPortugal (Lisboa), Member of theCouncil of the European ShockSociety and the Federation ofShock Societies, Editor-in-Chief(Europe) of the journal Shock,Chief Executive of William HarveyResearch Limited, and a Memberof the Institute of Directors.According to the Institute ofScientific Information, he is

one of the 100 most-citedpharmacologists in the world(based on citations in the past 20years). Professor Thiemermann’smajor research areas includeunderstanding ischaemia-reperfusion injury, shock andmultiple organ failure, His key aim overall is to develop novelapproaches for the therapy ofmyocardial infarction, acute andchronic renal failure and shock.Whenever possible, we strive totranslate the discoveries made in our experimental laboratories(Translational Research) into abetter understanding of thepathophysiology of disease withthe ultimate hope to improvetherapy (Translational Medicine).

Adam Timmis MA MB BChirMRCP MD FRCP FESCProfessor of Clinical CardiologyProfessor Timmis’ researchinterests focus on outcomes ofstable and unstable ischaemicsyndromes and the effects oftreatment and comorbidities,particularly diabetes. He holdsresearch awards from the SDO(principle investigator) and BHF(co-investigator). He currentlydirects the coronary care unit atthe Barts and The London Trustand participates in theinterventional programme in the catheter laboratories of theLondon Chest Hospital.

Peter Vanezis OBE MBChB MDPhD FRCPath FRCP(Glas)DMJ(path)Professor of Forensic MedicalSciencesProfessor Vanezis has aninternational reputation in forensicmedical sciences and wasawarded the Order of the BritishEmpire awarded in the Queen’sBirthday Honours List of June2001 for his Forensic PathologyServices in Kosovo. He plans, overthe next few years, to develop thevarious specialities in forensicmedicine and allied subjects andto reintroduce forensic medicineas an academic discipline withinthe University of London. At thepresent time there are noacademic centres in London.Thus there is no provision fortraining, teaching, research anddevelopment of the specialty. It isclear that there is an urgent needfor the re-introduction of a viableforensic medical centre in theLondon and the South East ofEngland. Professor Vanezis hasintroduced a forensic scienceoption module on the Institute’sBMedSci course and his ForensicHuman Identification course hasproved popular with students. Heis developing Diploma andMasters programmes in forensicmedical sciences.

Tim Warner BSc PhD Professor of VascularInflammationProfessor Warner’s researchinterests are into the formationand action of endothelial derivedfactors, especially prostanoids andendothelins. A particular focus of


current research is the roles ofdifferent enzyme pathways in theformation of prostacyclin andthromboxane A2 in blood vesselsand blood cells, and measures ofplatelet reactivity. Researches intoplatelet reactivity are beingpursued in collaboration withclinical colleagues in theHaematology Department, theErnest Cooke Vascular andMicrovascular Unit, and theCardiac Directorate of the Bartsand The London NHS Trust. Incollaboration with Professor YutiChernajovsky research isbeginning into the use of rationallydesigned latent anti-inflammatorycytokines to reduceatherosclerotic disease in thewalls of blood vessels. Within the European integrated project“Eicosanox” Professor Warnerheads the William Harveygrouping, one of five mainpartners (together with FrankfurtUniversity, the Karolinska Institute,University College London, andthe University of Chieti)researching into the roles ofeicosanoids and nitric oxide inhealth and disease. Eicosanox hasa total budget in excess of £10million. Experimental approachesused range from biochemical,molecular and cell culturetechniques, through cell imaging,to classical pharmacological organbaths, and short term in vivostudies. Professor Warner is listedby the Institute for ScientificInformation as being among thetop 0.5 per cent of citedpharmacologists.

Magdi Yaqoob MB BS MD FRCPLead Clinician, Academic Headand Unit training Director of theDepartment of Renal Medicineand Transplantation at the Bartsand The London NHS TrustProfessor Yaqoob’s researchinterests include experimental andclinical aspects of cardiovasculardiseases in uraemia, clinical andexperimental aspects of diabeticnephropathy, pleiotropic effects of erythropoietin, chemicalnephrotoxicity and mediators ofischaemia reperfusion injury andclinical aspects of transplantimmunology. Professor Yaqoobhas participated and lead in manysmaller and larger, multi-centretrials in renal and intensive caremedicine.

Shu Ye MD PhD FRCPath Professor of Molecular Medicineand GeneticsProfessor Ye graduated inMedicine in China and obtained a PhD from University College

London. His main researchinterests focus on: Therelationships of genetic variantswith CHD risk and othercardiovascular traits; Functionalcharacterisation of geneticvariants using a variety oftechniques; The role of Matrixmetalloproteinases (MMPs) inatherosclerosis, in particularatheromatous plaque rupture. We are studying MMP expressionprofiles in atherosclerotic plaques,looking at the regulation of MMPgenes in vascular endothelial cellsand macrophages, role of MMPsin atherogenesis using in vivomodels, and MMP gene variantsin relation to atherosclerosis andCHD susceptibility; Inflammationplays an important role in thepathogenesis of atherosclerosis,we are undertaking studies intocell signalling in response toatherogenic molecules.


Degree programmesWilliam Harvey Research Institute

MSc/PostgraduateDiploma/Postgraduate Certificate inAnalyticalToxicologyTwo to five years part-time

Programme description This programme is aimedprimarily at those practising in theclinical field, but will be relevantand useful to students who wishto follow a career in forensic,pharmaceutical, or environmentaltoxicology as the skills andknowledge base needed for thosedisciplines are complementaryand overlapping.

The programme aims to provide atheoretical basis for gainingcompetence in the practicalaspects of analytical toxicology; todevelop competence in researchand development activities; and toenable the participants to reviewanalytical data critically. Themodular nature of theprogrammes is designed to fit inwith the needs of those studentswho are in full-time employment.The taught elements of themodules are delivered in three-day blocks every six weeks.

Programme outline Year 1Module 1: Essential ClinicalToxicology • Module 2: AnalyticalTechniques I • Module 3:Analytical Techniques II • Module4: Essential Therapeutics •Module 5: Trace Elements and

Toxic Metals • Module 6: DrugAbuse and Forensics

Year 2 Module 7: EssentialClinical Biochemistry • Module 8:Laboratory Operation • Modules 9– 12: Practical Project andDissertation (or CriticalDissertation)

Assessment For a Postgraduate Certificate,students must complete and passmodules one to four. Successfulcompletion of all eight taughtmodules leads to the award of the Postgraduate Diploma.Completion of a practical projectand submission of a dissertationbased on the project ofapproximately 20,000 words andsuccessful completion of all eighttaught modules is required for theMSc award. The assessment ofthe taught modules is 100 percent by continuous assessmentwith submission by the student of essay-style answers, a series ofshorter answers or a mixture ofboth.

Entry requirementsFor entry onto the programmestudents will need either anappropriate life sciences degree or equivalent from a recognisedacademic institution, or anappropriate professionalqualification or experienceacceptable to the ProgrammeDirector and Director of GraduateStudies.


Further informationProfessor Atholl JohnstonTel: +44 (0)20 7882 3404email: [email protected]

MSc/PostgraduateDiploma in ClinicalDrug DevelopmentMSc/PostgraduateDiploma inHealthcareResearch MethodsOne year full-time, two to five years part-time

Programme description Over the last 30 years healthcareresearch and drug developmenthave been transformed fromperipheral activities carried out onan ad hoc basis to become coreactivities that require trained,professional staff. However, theeducation and training of staffinvolved in healthcare researchand drug development has notkept pace with the scientific andregulatory changes that haveoccurred over this period. For thisreason the Clinical PharmacologyCentre of the William HarveyResearch Institute, in associationwith Barts and The London NHSTrust and HammersmithMedicines Research, hasdeveloped modular postgraduateprogrammes in healthcareresearch and in clinical drugdevelopment. The programmesare designed to give individualsthe necessary academic


background and specialist skillsneeded to carry out clinical drugdevelopment or healthcareresearch in a contract researchorganisation, pharmaceuticalindustry or Health Serviceenvironment.

Our target audience is graduates,nurses, medical doctors and otherhealth professionals working incontract research organisations,the pharmaceutical industry andhealthcare.

Programme outline These two postgraduateprogrammes share a commonspine, which cover the key areasof expertise needed for asuccessful clinical researchprogramme. For studentschoosing the Clinical DrugDevelopment programme theinitial modules will concentrate onearly drug development whereasfor those students taking theHealthcare Research Methodsprogramme the emphasis will berelated to health management.

The modular nature of theprogrammes is designed to fit inwith the needs of those studentswho are in full-time employment.The taught elements of themodules are delivered in three-day blocks every six weeks.

Core modulesClinical Study Design • PracticalAspects of Clinical Research andEarly Drug Development • Ethicsand Regulation • DataManagement and Statistics •Specific Topics in Clinical Trial

Design • Elective Dissertation •Health Outcomes andPharmacoeconomics • MarketingHealthcare • ResearchProject/Dissertation

Module options include:Health and the Human Body •Healthcare Organisation andDecision Making • Drug Discoveryand Preclinical Research andDevelopment • Toxicology

Assessment For a Postgraduate Diploma,students must complete and pass eight modules. Successfulcompletion of a further fourmodules, two of which willcomprise a critical dissertation ofapproximately 20,000 words, isrequired for the MSc award.

The assessment of the taughtmodules is 100 per cent bycontinuous assessment withsubmission by the student ofessay-style answers, a series ofshorter answers or a mixture ofboth. These are marked andreturned to the studentsaccording to the timetablespecified in the ProgrammeHandbook. There is no finalwritten examination.

Entry requirementsFor entry onto the programmestudents will need either anappropriate degree or equivalentfrom a recognised academicinstitution, or an appropriateprofessional qualification (forexample nursing) or experienceacceptable to the ProgrammeDirector and Director of GraduateStudies.


Further informationProfessor Atholl JohnstonTel: +44 (0)20 7882 3404email: [email protected]

MSc/PostgraduateDiploma inEndocrinology and DiabetesTwo years part-time – distance learning

Programme descriptionThe Postgraduate Diploma isdesigned both as a completecurriculum in endocrinology anddiabetes for new entrants intothese fields and as an update andextension for those already in it.The course provides clinicianswith theoretical and clinicallyapplied aspects of their discipline.

The programme will incorporateelements of the UK specialtytraining curriculum forendocrinology and diabetesmellitus including aspectsassessed at the knowledge-basedexamination required for RoyalCollege Certification. In additionthere will be a focus on up to datedevelopments in the field andexpert opinions and presentations.

In addition, students taking theMSc do a project on a topic to beapproved by the Course Organiserwhich is conducted at thecandidate’s home institution. The



project is examined in the form ofa written dissertation ofapproximately 10,000 words anda viva.

Programme outline Modules include: • Hypothalamus and pituitary

• Thyroid, parathyroids and bone

• Reproduction, pregnancy andpaediatric endocrinology

• Appetite, weight, energymetabolism, lipid metabolism

• Adrenals (medulla and cortex)

• Genetics, endocrine oncology,neuroendocrinology

• Diabetes mellitus

• MSc Project

Assessment Assessment for each module iscompleted during the progress ofthe module and submitted at theend of the module.

The assessment format varies witheach module (for example, EMQand ‘best of 5’ multiple choicequestions or short answer formator longer essays).

There is an end-of-coursesummative assessment aftercompletion of all eight modules.This comprises of a written papercomprising a combination of shortanswers, longer essay answersand ‘best of five’ multiple choicequestions. The exam will assesscontent from each of the modulesequally and the marks for theexam will be evenly distributedacross the modules taught.

Entry requirementsQualification requirements for the course are MB BS or basicmedical degree from universitiesrecognised by the University ofLondon.

Candidates should generally have worked for one year afterregistration (two – three years post qualification).

Applicants will be interviewedprior to acceptance and courseentry may be competitive.Students must have access to asuitable computer and broadbandaccess to the internet. Availabilityof minimum system specificationsfor using WebCT CE6 is required.Students must be able to sitexaminations at a British CouncilCentre under invigilation or beable to attend examinations in theUK.


Further informationDr Maralyn Druce Tel: +44 (0)20 7601 7078email: [email protected]

MSc/PostgraduateDiploma/PostgraduateCertificate inForensic MedicalSciencesOne year full-time, two to five years part-time

Programme descriptionThis programme aims to respondto the national and internationalneed for professionals who canapply a critical and scientificapproach to their forensicpractice, and who wish to have a broad understanding of thevarious interrelated disciplines of forensic medicine and science.The programme will providetheoretical and practicalknowledge of the forensic medicalsciences, and will train studentsto be able to critically evaluateand interpret forensic medical andscientific evidence.

The programme will cover severalaspects of forensic medicalscience and there is no otherprogramme which offers such awide range of specialist topicsunder the umbrella of the forensicmedical sciences, coupled withthe opportunity to carry outresearch in a specialist area.

The programme offers theopportunity for graduates tofurther their career prospectswithin their own professionalspecialty. The programme should


be regarded as intermediate levelfor pathologists and forensicmedical examiners who will beexpected to progress to specialistexit level exams, through theirrespective Academic Colleges.

Programme outline Core modules

Clinical Aspects of ForensicMedicine (two modules) •Forensic Pathology (two modules)

Module optionsLegal and Ethical Issues Relevantto Forensic Medicine and Science

• Forensic Toxicology I and II •Forensic Identification I and II

Research projectLaboratory based or a criticaldissertation (four modules)

AssessmentFull attendance is expectedthroughout the programme and is a pre-requisite for successfulcompletion of the programme.

For a Postgraduate Certificate,students must complete and passfour modules. Successfulcompletion of a further four

modules leads to the award of thePostgraduate Diploma, completionof a practical project bycandidates awarded the Diplomaand submission of a dissertationof approximately 20,000 words isrequired for the MSc award. Thefull programme comprises twelvemodules, with each contributingequally to the final mark (onetwelfth of the total). The result ofone module contributes amaximum of 8.33 per cent andthe project a maximum of 33.33per cent to the final mark.

‘‘‘‘Neil Dufton, PhD in Inflammation and Immunology

My tutor at Bath was a former friend and colleague ofProfessor Flower and both undertook their PhD research withJohn Vane who set up the William Harvey Institute. I came foran interview and was immediately struck by the enthusiasm forboth my project and the progression of science in thedepartment.

I am currently getting to grips with a huge number of newtechniques ranging from molecular biology, in vitro immunologyand in vivo pharmacology so there is plenty to keep me out oftrouble.

I have two very dynamic Professors, Perretti and Flower, as mysupervisors who are always open for discussion, often leadingto a raft of new ideas for both current and future work. Thegroup is always willing to help by either providing technicalexpertise or just bouncing ideas that may relate to their field ofinvestigation.

Charterhouse Square green is a great place to spend you lunch break when the sun is shining, and withthree barbecues available for general use you will often see people gathering on a summer evening. TheWilliam Harvey has a good social scene with curry nights, barbecues and a marquee ball in the summer.There is also an annual five-a-side football tournament that often leads to some amusing rivalriesbetween labs.

I enjoyed convincing fifteen colleagues predominantly from my department to take part in a four-milecharity space hop around London City for Red Nose Day. It was a great day all round, especially seeingthe professors on hoppers before we embarked round London, and we managed to raise more than£2,500.



Core and other modules will beassessed through tutorial work(including paper presentations),submitted assignments, practicalreports and short examinations(Short Answer Questions orMultiple Choice Question format).There will be variation in therelative contribution of eachassessment method withinmodules.

Entry requirementsFor language requirements,please see the internationalstudents section on page 133.

Further informationProfessor Peter VanezisTel: +44 (0)20 7882 3401email: [email protected]

MResInflammation:Cellular andVascular AspectsOne year full-time

Programme description The MRes in Vascular andCellular Inflammation provides a practical training in modernmolecular and proteomic researchtechniques and their applicationto traditional methods ofpharmacological investigation ofinflammatory and vasculardisease mechanisms. Theprogramme is specificallydesigned to develop the skillsnecessary to conduct biomedicalinflammatory research, forexample in rheumatoid arthritis,

atherosclerosis, hypertension,diabetes, nephrology, or cancer,and draws upon the uniquecombination of expertise ininflammatory disease, vasculardisease and pharmacology foundin the William Harvey ResearchInstitute. It is therefore aninvaluable foundation if you wishto pursue a career in industry oracademic research. Manystudents have continued on tocarry out a PhD within the School.

Programme outline In the first term students follow an initial three-month course oftutorials and practicals to obtain abroad grounding in inflammationmechanisms, and to develop thenecessary laboratory skills forconducting the project element of the programme. This is split up into generic skills (ie writing,presentation skills, statistics,laboratory safety and criticalanalysis), proteomics, molecularmethods, immunological andpharmacological methods. In thefollowing two terms, students areexpected to apply a variety oftechniques as part of anintegrated research project underthe guidance of an experiencedacademic supervisor.

Coursework continues throughoutthe year. Students are able todevelop their scientificunderstanding through the use ofproblem based learning (studentswrite-up one PBL as adissertation) and critical analysisand appraisal of key researchpapers.

AssessmentCoursework (36 per cent), Criticalanalysis of the literature (24 percent) and dissertation (12 percent).

Research project (64 per cent).This forms the major part of theassessment and is divided intothree elements, project write-up(50 per cent), project presentation(6 per cent) and project viva (8per cent).

Entry requirementsThe programme is suitable for life science graduates, with aminimum second class honoursdegree (or the equivalent from anoverseas university), MB BS withor without an intercalated degree.


Further informationDr Martin CarrierTel: +44 (0)20 7882 2104/2218email: [email protected]

Barts and the London School of Medicine and Dentistry107

Wolfson Institute ofPreventive Medicine


Wolfson Institute of Preventive Medicinewww.wolfson.qmul.ac.uk

Institute DirectorProfessor Nick Waldemail: [email protected]

Director of Graduate StudiesProfessor Stephen Duffyemail: [email protected]

Key research areasEnvironmental and preventivemedicine, epidemiology, antenatalscreening, cancer screening,medical statistics and psychiatry.

The Wolfson Institute ofPreventive Medicine is aninternationally renowned centre of excellence in epidemiology and preventive medicine that hasagain been highly rated in therecent Research AssessmentExercise (2008), with a gradepoint average (epidemiology) of 3.05. It is dedicated to thereduction of diseases anddisability through its focus onacademic discipline, research, thetranslation of research into publichealth strategies and theirpractical implications. Theresearch foci are screening, earlydetection and disease prevention.The Institute has a strong interestin medical statistics where thework focuses on methods forrunning trials, analysing the dataand developing new methodologyfor statistical problems arisingfrom epidemiological research.

The Institute comprises:

• Centre for Environmental and Preventive Medicine

• Cancer Research-UK Centre for Epidemiology, Mathematics and Statistics

• Centre for Psychiatry

Centre for Environmental andPreventive Medicine (CEPM)CEPM focuses on large-scalerandomised prevention trials,screening research (antenatal and cancer) and epidemiologicalstudies into the causation ofdisease, especially cardiovascular.It includes the TobaccoDependence Research Unit, oneof the leading centres in this fieldthat operates a large smokers’clinic providing an ample clinicalbase, to support its extensiveresearch programme. There areopportunities for postgraduateprojects concerning bothbehavioural and pharmacologicalapproaches to understanding andtreating nicotine dependence.

Cancer Research-UK Centre forEpidemiology, Mathematics andStatistics (EMS)EMS focuses on mainly clinicaltrials and epidemiology and thework tends to be collaborative.Current areas of interest arecancers of the breast, uterinecervix, prostate and colorectum.The work of this Centreencompasses prevention studies,treatment comparisons,prognostic factors for survival andaetiological studies of risk factors

for developing disease. The centrealso now is the home of the onlyClinical Trials Prevention Unit forcancer prevention and screeningtrials in the UK.

Centre for PsychiatryThe Centre for Psychiatry is amultidisciplinary centre of socialscientists, psychologists andpsychiatrists with special interestin ethnicity and culture, healthservices research and policy, andforensic, community and socialpsychiatry. The work of the Centretakes advantage of its location in a multicultural population of eastLondon, whilst also being ofimportance to international mentalhealth research. The Centre’sresearch includes strengths in:epidemiological psychiatry(environmental and cultural,forensic, bio-psycho-social) andmental health services researchthat develops concepts andprocesses in therapeuticinterventions and trials of complexinterventions. The Centre alsodelivers MScs in TransculturalMental Healthcare andPsychological Therapies andworks with NHS service providersin east London and national andinternational partners in researchand policy. The Centre ispioneering E-learning andsimulated learning environmentsand research into theireffectiveness.


Wolfson Institute of Preventive Medicine

Graduate profile: Rhian Gabe

Studied: An epidemiological / statistical basedPhD on the evaluation of breast cancer screeningusing mammography – graduated 2007

Currently: I’m a senior statistician at the MedicalResearch Council’s Clinical Trials Unit (MRCCTU). I’m project lead for a number of innovativestudies (randomised trials) that aim to find thebest therapies and care for patients with cancer.

Why did you choose Queen Mary?My background in mathematics andepidemiology, and an interest in cancer researchled me to the Cancer Research UK centre forEpidemiology, Mathematics and Statistics at theWolfson Institute. This department and theMedical School as a whole at Queen Mary havegood international reputations for cancerresearch. I was very interested in cancerepidemiology and in particular breast cancerscreening. I knew the Centre had some of the topresearchers in this field (Professors Duffy, Cuzick,Sasieni) and I was familiar with their work. I

visited the Centre and came away thinking thatnot only did they have a range of exciting projectsbut these Professors and their colleagues werefriendly, easy to talk to and learn from. I was notwrong and enjoyed my time there immensely.This research environment kept me motivatedthroughout my studies and I finished my PhD inthree years.

What did you gain from your time at Queen Mary?A greater in-depth knowledge of cancerscreening and prevention. Less obvious, is thegreater confidence acquired as a researcher,which comes from developing the right skill set,such as initiating and writing papers, presentingwork at international conferences, formulatingresearch ideas and applying for funding, andcommunication and contacts for successfulcollaborations. I also enjoyed meeting a variety of people and made some good friends along the way!

What are your career plans in the next five years?While I’m lucky enough to have found apermanent position with the MRC, it’s still hard to know where your work will be in five years, as it depends on the projects we manage to getfunded. I think studies in prostate and lungcancer, especially in the areas of prevention,screening or treatment of early disease should behigh priority for cancer research. I’m trying to usemy experience from my PhD and from clinicaltrials to take things in that direction with mycurrent portfolio of work. The next step up interms of a career at the MRC CTU would be“programme leader” (which is equivalent to agroup lead in a university setting) and hopefullymy current experience and efforts to get studiesoff the ground will help towards this.


Senior staff research interestsWolfson Institute of Preventive Medicine

Kamaldeep Bhui MDFRCPsych(Lond)Professor of CulturalPsychiatryand EpidemiologyKamaldeep Bhui's researchinterests include methodologicalinnovations for researching healthand social care of cultural andethnically defined populationgroups. Investigations are locatedat the interface betweenepidemiology and socialanthropology to improve researchquality in hard to reach andsocially excluded populations andpatient groups, for example, thehomeless and refugees andasylum seekers. As part ofresearch and service developmentroles, Professor Bhui pioneeredthe EPIC service innovations(enhancing pathways to care) andled on the outcomes compendiumfor professionals to use in mentalhealth care. He is involved in theevaluation of a nationalprogramme to improve raceequality in mental healthcare. He has championed culturalcompetency and culturalconsultation processes to developa skilled workforce that candeliver improved patient outcomesin a culturally diverse society.Current work includes asystematic review of the culturalcompetence literature, new dataon suicide and self harm amongethnic groups, and MRC fundedstudies of chronic fatigue andchronic fatigue syndromes,including a systematic review ofethnicity and chronic fatigue. Newwork includes investigations ofpersonality disorder (DH), workstress and the interventions to

‘‘

‘‘Staff profile: Dr David WaldSenior Lecturer and Consultant Cardiologist

As an Interventional Cardiologist,my main interest lies in theprevention of cardiovasculardisease, in particular bridgingthe interventional and preventiveapproaches to cardiovasculardisease which are often viewed as distinct. I am currently co-ordinating a proposedrandomised trial to assess thevalue of coronary angioplasty inpreventing future coronary heart

disease among patients receiving angioplasty to treat an acutemyocardial infarction.

This follows a randomised trial which showed the minimum fullyeffective dose of folic acid for serum homocysteine reduction, forwhich I was awarded the BMA Brackenbury Research Prize.

I have acted as an adviser to the Food safety Authority of Ireland inhelping them reach a decision on dietary fortication with folic acid.In collaboration with other members of the Institute, this led toresearch into the expected effect of folic acid intake oncardiovascular disease prevention. This in turn showed how even the largest randomised trials of folic acid supplementation wereunderpowered to show the expected effect.

Another recent joint initiative involved showing that screening forfamilial hypercholesterolaemia, by serum cholesterol measurement,is effective if done in early childhood after the first year of life. Thisfinding underpins a novel “child-parent” population screeningstrategy that screens children and their parents within the sameprogramme. This involved assessing imaging techniques like carotidultrasound and CT scanning in screening for coronary heart diseaseto determine their value in medical practice.

Additionally, I coordinate the Polypill Prevention Programme, a novelservice that adopts the Polypill approach in coronary heart diseaseand stroke prevention.


improve workforce stress (DH)and workforce capacity to workwith diverse populations.

Jeremy Coid MB ChB(Sheff)MRCPsych Mphil DipCriminol(Lond) FRCPsychMD(Lond)Professor of Forensic Psychiatry, Director of the Unit of ForensicPsychiatryJeremy Coid’s current principleresearch interests are theepidemiology of violence and high risk behaviour and theassociations between thesebehaviours and mental disorder.Current research, which includesan NIHR programme grant,comprises an evaluation ofdifferent methods of riskassessment for further seriousoffending in prisoners releasedinto the community, thetransmission of delinquency fromfathers to their children, and aprospective study of first episodepsychosis in east London.Previous research has examinedthe development of secureforensic psychiatry services in England and Wales andadmissions to these facilities in relation to socio-economicdeprivation. He is currentlyConsultant in Forensic Psychiatryto the East London ForensicPsychiatry service, ConsultantAdviser to the National Institute of Mental Health, a member ofthe Research Advisory Group tothe Home Office in theirprogramme for Dangerous andSevere Personality Disorder, andis a member of the monitoring

group of the Close SupervisionCentres, Prison Directorate.

Jack Cuzick BSc(Claremont,California) MSc(Lond)PhD(Claremont, California) ,FMedSci, FRSS, FIMSJohn Snow Professor ofEpidemiology, Head of CancerResearch-UK Centre forEpidemiology, Mathematics and StatisticsJack Cuzick’s interests are incancer prevention and screeningwith special attention to breast,cervix, colon and prostate cancer,and the development of statisticalmethodology. He is working withthe aromatase inhibitors both fortreatment and prevention ofoestrogen receptor positivepostmenopausal breast cancer.He is conducting the IBIS-IIchemoprevention trial comparinganastrozole with placebo in 6,000high risk women. There is alsointerest in mammographic breastdensity as a biomarker for riskand early indications of riskreduction when interventions areused. The main thrust in cervicalcancer has been the use of HPVDNA testing in screening with arecent Lancet paper on the HARTstudy of 11,000 women. A largestudy of 2,500 men with clinicallylocalised prostate cancertreatment is ongoing by watchfulwaiting. Tissue arrays have beenprepared to look for new markersof aggressive disease and severalpapers have been published. Alarge randomised trial of once-only flexible sigmoidoscopy as apopulation based screeningmethod for colorectal cancer in

men and women aged 55-64 isalso in the late follow-up stage. He is currently president of theInternational Society for CancerPrevention.

Stephen Duffy BSc(Edin)MSc(Lond) C StatProfessor of Cancer ScreeningStephen Duffy’s main researchinterests are: cancer screeningevaluation; markers of cancer riskand prognosis; and epidemiologyof dense, high-risk breastpatterns. Grant-funded researchincludes the NHS-fundedevaluation of mammographyscreening in young women with a family history of the disease, afeasibility study for a lung cancerscreening trial in the UK, alsofunded by the NHS, and aninvestigation of computer-aideddetection in breast screening,funded by Cancer Research UK.Recent publications include apaper on the use of computer-aided detection in the NewEngland Journal of Medicine anda commentary on the possibilitiesfor collaboration in lung cancerscreening in Lancet Oncology.

Peter Hajek MA(UJEP)PhD(Charles University) C ClinPsycholProfessor of Clinical PsychologyPeter Hajek’s main researchinterest focuses on tobaccodependence and its treatment. He directs the TobaccoDependence Research Unit at theRoyal London Hospital. He hascontributed to the development of a range of behavioural andpharmacological treatments for



dependent smokers used in theUK and worldwide. His unit is alsoinvolved in studies of weightmanagement. His research hasbeen supported by grants fromsources such as DoH, WellcomeTrust, MRC, HDA, NELHA,pharmaceutical industry andothers. He is a member of anumber of editorial boards, expertgroups and advisory committees,and his Unit is a part of the UKCentre for Tobacco ControlStudies.

Ania Korszun PhD MB BSMRCPsychProfessor of Psychiatry and EducationAnia Korszun’s research focuseson mood disorders andparticularly on the interface ofdepression and stress with othermedical conditions. She hascompleted studies onhypothalamic-pituitary-adrenalaxis function in facial pain,fibromyalgia and chronic fatiguesyndrome and has been Co-PI onlarge multi-centre genetic studiesof depression. Further work hasfocused on identifying theunderlying pathophysiologicalmechanisms that link depression,stress and atherosclerosis, namelyendothelial dysfunction andreduced baroreceptor sensitivity.More recently, she is working incollaboration with colleagues fromsurgery and oncology on theidentification of psychological and physiological predictors oftreatment outcome in cancerpatients.

Ania Korszun maintains a strongcommitment to medicaleducation. She is the AcademicLead for Psychiatry Education,Systems Lead for Brain andBehaviour and Academic Tutor inMedical Professionalism at Bartsand The London School ofMedicine and Dentistry, QueenMary, University of London. She is conducting research onundergraduate teaching andassessment of medicalprofessionalism and theeffectiveness of interdisciplinaryteaching of clinical skills inpsychiatry and leading a largemultidisciplinary project thatfocuses on overcomingstigmatizing attitudes to mentalhealth.

Malcolm Law MB BS(Adelaide)FFPH FRCP MSc(Lond)Professor of Epidemiology and Preventive MedicineMuch of Malcom Law’s work hasbeen in the prevention of heartdisease and stroke, with seminalpublications on salt and bloodpressure, serum cholesterol andheart disease, passive smokingand heart disease, and thereasons for the low heart diseasemortality in France (the Frenchparadox). Quantification of theeffects of changing risk factors on the incidence of myocardialinfarction and stroke has been aprominent feature of his work.Publications with Professor Waldand other colleagues on the effectof statins (according to specificstatin and dose) on LDLcholesterol and on risk of heartdisease and stroke, of the five

main categories of blood pressurelowering drug according to doseon blood pressure and on risk ofheart disease and stroke, and offolic acid on serum homocysteineand risk of heart disease andstroke led to the calculations ofthe effect of the ‘Polypill’ inpreventing ischaemic heartdisease events by 88 per cent and stroke by 80 per cent.

Attila Lorincz PhDProfessor of MolecularEpidemiologyAttila T Lorincz is a molecularbiologist recognized for hisresearch in human diagnosticsand the natural history of humanpapillomavirus (HPV) infections.Attila Lorincz’s work on HPVbegan as a collaboration with theNobel Laureate Professor HaraldzurHausen. In the years leadingup to 1990 he cloned andcharacterized several clinicallyimportant HPV types, provided aclearer understanding of thenatural history of HPV infectionand pioneered large clinicalstudies that revealed key evidenceof the association of HPV withcervical cancer. In 1990 AttilaLorincz co-founded DigeneCorporation (now QIAGEN Corp.)where he assumed the post of Sr.Vice President R&D until 2006.His work on a non-radioactiveassay for HPV culminated in theUS FDA approval of the HybridCapture (HC) series of HPV tests.These nucleic acid amplificationtests are generally recognized asthe gold standard in routine HPVscreening worldwide, with 10+million tests conducted annually.


More than 40 US andinternational patents concerningnovel HPV types and novel assaysystems have been awarded forhis work. He has authored 210original peer-reviewed researchpapers and books on diversetopics in epidemiology and thebasic molecular mechanisms of carcinogenesis. His currentresearch interests focus on theinterplay between genetics andepigenetics in the developmentand evolution of prostate, breast,and cervical cancers. His teamhave discovered and credentialedseveral new cancer biomarkersthat appear promising indiagnostics and are beinginvestigated for prognostic andpredictive potential.

Joan Morris BA MA(Cantab)MSc(Oxon) PhD(Lond) CstatProfessor of Medical StatisticsJoan Morris’s main researchinterest is in evaluating theeffectiveness of prenatalscreening strategies for differentdisorders, for example cysticfibrosis, fragile X syndrome,neural tube defects and Down’ssyndrome. As Director of theNational Down SyndromeCytogenetic Register she has astrong interest in the screening of, and epidemiology of, Down’ssyndrome. She is interested instatistical methodology withrelevance to screening and riskassessment. Her work withProfessors Nicholas Wald andMalcolm Law has involved manymeta-analyses investigating thevalue of low dose combinationtreatment with blood pressurelowering drugs, and the

associations of folate and serumhomocysteine with cardiovasculardisease, culminating in thepublication of a trio of papers inthe British Medical Journal on the prevention of cardio-vasculardisease by the use of the ‘Polypill’.

Stefan Priebe Dipl-Psych, Dr.med. (Hamburg) habil. (Berlin)Professor of Social andCommunity Psychiatry, Director of the Unit for Social andCommunity PsychiatryStefan Priebe’s extensive researchactivities have focused on threeareas: mental health servicesresearch including outcomestudies and trials of complex andinnovative interventions; patientviews (eg subjective quality of lifeand treatment satisfaction),therapeutic relationships andtherapeutic communication inpsychiatry; and studies on the

‘‘ ‘‘

James Cook, PhD in medical statistics

I am currently looking at the prevalence of trisomy 13 and trisomy 18in England and Wales as part of my PhD in medical statistics. I'dheard good things about the quality of research at Queen Mary, it waspart of the reason I chose to study here. I’m now surrounded byexcellent researchers, all of whom are happy to help and support mehowever they can. Working in central London has its perks too!

The facilities are amazing. Charterhouse Square and Whitechapel bothhave superb departments for medical research, and the Educationaland Staff Development (ESD) department at Mile End is great forlearning more general skills. Sitting outside in Charterhouse Square isa great place to work in the summer.

I also work as a Problem Based Learning (PBL) facilitator on theundergraduate medical degree programme. It's a really interesting wayto teach, which I think works much better than constant lectures.



history and concepts of mentalhealthcare. He has a specialinterest in advancingmethodological and conceptualissues, has co-ordinated anumber of major European multi-centre studies and is DeputyDirector of the Pragmatic ClinicalTrials Unit. He is author/ editor ofeight books and has more than400 scientific publications, twothirds of them in peer-reviewedjournals. He reviews on socialpsychiatric issues for most leadingjournals and research funders andis on the editorial board of severaljournals, including PsychiatrischePraxis and the InternationalJournal of Social Psychiatry.Professor Priebe is visitingprofessor at the HumboldtUniversity Berlin, the University ofModena and Reggio Emilia, andthe University of Belgrade. He hasbeen a member of the NationalMental Health Task Force inEngland and acting as advisor onmental healthcare development to regional and national bodies in several European countries.

Peter Sasieni BA MA(Cantab) MSPhD(University of Washington)Professor of Biostatistics andCancer EpidemiologyProfessor Sasieni’s researchfocuses on cancer screening andthe prevention of cervical cancerboth in the developed and thedeveloping world. He is alsointerested in statisticalmethodology with relevance toclinical trials and epidemiologicalresearch. He is currently runninga randomised controlled trial ofdiindolylmethane (DIM) in the

treatment of women with mildlyabnormal cervical smears in anattempt to prevent progression tohigh-grade disease. Hispublications include Benefit ofCervical Screening at DifferentAges: evidence from the UK Auditof Screening Histories (2003), aswell as numerous papers onHuman Papillomavirus (HPV)testing, breast screening andstatistical methods in survivalanalysis. He also maintains aninterest in statistical analysis ofdata from molecular biology. Heholds research awards/grantsfrom Cancer Research-UK, theNHS Cervical ScreeningProgramme and the EuropeanUnion.

Stephen Stansfeld MB BSPhD(Lond) MRCP MRCPsychProfessor of Psychiatry, CentreLead for PsychiatryStephen Stansfeld’s researchinterests include the effects of thephysical and social environmenton mental health. He has beeninvolved in several studiesexamining environmental noise

and mental health and morerecently on noise and children’shealth and cognition. He waspreviously Co-Director of theWhitehall II Study and isparticularly interested in thepsychosocial work environmentand social support as predictorsof common mental disorder. He has also investigated theexplanations of the social gradientin psychological distress in theWhitehall II Study and withProfessor Chris Power in the 1958Birth Cohort. He is interested inpsychosocial influences,especially depression, on coronaryheart disease and has co-edited abook on the impact of theenvironment on psychiatricdisorder. He is principalinvestigator in the RANCH andRELACHS Studies. He also worksas a consultant psychiatrist inpsychiatric rehabilitation.

Nicholas Wald MB BS DSc(Lond)FRCP FFPH FRCOG FMedSci CBiolFlBiol FRSInstitute Director Wolfson Instituteof Preventive MedicineProfessor Wald is known for hisresearch in epidemiology andpreventive medicine. He haspioneered the field of antenatalscreening for congenitalmalformation and madediscoveries that form the basis ofscreening for neural tube defectsand Down’s syndrome in earlypregnancy. He showed, in a largerandomised trial, that a lack offolic acid is a cause of neural tubedefects, and that an adequateintake of the vitamin immediatelybefore pregnancy can prevent


most cases. He has demonstratedthat passive smoking is a cause oflung cancer and with ProfessorLaw showed it also increased therisk of ischaemic heart disease.Screening procedures for earlydetection of certain cancers,notably breast cancer, have beenadvanced from his work. WithProfessor Law, he clarified therelationship between salt intake,blood pressure and cardiovasculardisease. Recent research activitiesinclude screening and treatmentfor Heliocobacter pylori infectionand subsequent stomach cancer,and screening and treatment ofhypothyroidism in pregnancy and subsequent intellectualdevelopment in children. He isthe innovator of the ‘Polypill’, aradical approach to the preventionof cardiovascular disease, andtrials are being developed. He haspublished widely in these areasover the past 30 years. His book,Antenatal and NeonatalScreening, won first prize in theBMA Medical Book Competition(2001) in the public healthcategory.

Peter White OBE BSc MB BSMD(London) FRCP FRCPsychProfessor of PsychologicalMedicinePeter White’s main research is inmind-body medicine, exploringthe aetiology and treatment offatigue and pain, specificallychronic fatigue syndromes (CFS –also known as myalgicencephalomyelitis, ME), post-viralfatigue syndromes, and diffuseupper limb pain disorder.Research successes include:establishing and replicating thediscrete nosology of both acuteand chronic fatigue syndromesafter glandular fever, showingEpstein-Barr virus can triggerCFS, establishing theheterogeneity of CFS in general,demonstrating the interactionbetween mind and body in thepathophysiology of CFS, andproviding the first evidence (since

replicated) that graded exercisetherapy is an effective treatmentof CFS. His work in regional upperlimb pain has shown that bothphysical and psychological factorsare important whether or not thepathology is established, and thatpain is likely to be maintained bycentral nervous systemsensitization. He is currently chiefinvestigator of the PACE trial(www.pacetrial.org); the largestever treatment trial for CFS. Hisrecently edited bookBiopsychosocial Medicine (OUP)concludes that an integratedbiopsychosocial managementapproach should be mandatoryfor all chronic medical conditions.


Degree programmesWolfson Institute of Preventive Medicine

MSc/PostgraduateDiploma in MentalHealth:PsychologicalTherapies MSc/PostgraduateDiploma in MentalHealth:TransculturalMental HealthcarePgCert AdvancedMental HealthAssessmentOne year full-time, two yearspart-time. Distance learningoption available

Programme descriptionStudents on this programme aim to:

• Develop more advancedunderstanding of the basis of assessment, diagnosis,formulation and caremanagement of psychologicaldisorders in general and then in diverse racial, ethnic andcultural groups drawing oncultural psychiatry, socialsciences and allied disciplines

• Have access to an academicprogramme that preparescompetent practitioners todeliver effective mental healthtreatments for people withpsychological problems

• Develop knowledge of researchmethods and systematic andcritical review

• Develop and have access to a network of mental healthprofessionals and establishedacademics

Students on the TransculturalMental Healthcare programmewill learn how to improve theirassessment of mental healthproblems. The specific strength of the MSc is that students willdevelop a knowledge baseinformed by a socialanthropological, medical,sociological, epidemiological andpharmacological understanding ofthe presentation, expression andmanagement of mental disordersand psychological distressamongst Black and Ethnicminorities.

Students on the PsychologicalTherapies programmes will alsolearn and utilise an advancedlevel of knowledge derived fromdifferent psychologicalinterventions including:

• Therapeutic paradigms

• Cognitive behavioural therapies

• Cognitive analytic therapies

• Group therapies

• Family therapy

• Psychoanalytic andpsychodynamic therapies

• Bio-psycho-social model

Programme outlineThe MSc programme consists of three 12 week modules.

Module 1 (Advanced MentalHealth Assessment) is compulsoryand completion of this alone isaccredited for exit with acertificate in mental healthassessment. This is a compulsorymodule for all students.

Module 2 We offer two pathwayoptions: psychological therapies or transcultural mental healthcare.Completion of this module andmodule one permits exit with adiploma in either PsychologicalTherapies or Transcultural MentalHealthcare.

Module 3 This is compulsory to all students and includes researchmethods and evidence basedpractice. Students aiming for the MSc award are required toundertake a dissertation on anoriginal topic that includes originalresearch or an original andcomprehensive literature reviewusing systematic methodswherever possible. Completion of modules one, two and three isaccredited for exit with an MSc ineither Psychological Therapies orTranscultural Mental Healthcare.

Postgraduate Certificate Full-time: completion in one term Part-time – N/A

Postgraduate Diploma Full-time: both modules arecompleted in Year One.

Part-time: One module iscompleted in each year.


MScFull-time: all three modules arecompleted in one year.

Part-time: we advise students thatit is best to complete the first twomodules in the first year, and thethird (research module) in YearTwo. However, we permit flexibilityif individual circumstances requirethis and if this still provides thestudent with the best chances ofprogressing.

The MSc programme includesthree modules, each lasting 12weeks, and each with 12 coreteaching and learning days. Theseare complemented by a half-daywork placement (TransculturalMental Healthcare students) formodule two or half a day a weekof supervised treatment of twoshort cases of 12 to 20 sessions(for students following thePsychological Therapies pathway)to develop better practices in realclinical settings. Students preparea report on this as part of theprogramme assessment formodules one and two. There arealso PBL sessions (one a week),and time is required to read twokey references each week andprovide a précis each week.

AssessmentModule 1: Practice placementplan, clinical therapy (one brieftherapy), research or literaturereview plan, tutor's assessmentreport on PBL write ups, oral andwritten examination.

Module 2: Practice placementreport or clinical practice (twobrief cases), pilot study report forthe main study, studentpresentation, tutor's assessmentreport on PBL write ups and oraland written examination.

Module 3: Tutor's assessmentreport on PBL write ups andattendance, grant writing report,dissertation (10-15,000 words),supporting publications andwritten examination.

Both programmes are alsoavailable as distance learningoptions. All students have accessto our established E-learningfacilities for each programmemodule, including: onlineprogramme syllabus (studenthandbook); Tools for E-lecturematerials; Tools for online PBLmaterials; Tools for submittingonline assignments/homework

WebCT email; Virtual discussionboard; Virtual classrooms(synchronous); E-calendar Toolsfor online student feedback; Toolsfor students to track onlineresults/progress; E-notice boardand Skype tutorials as well asSkype add-ons (ie whiteboard) to facilitate virtual classroominteractions. In addition, lecturesare recorded using screen capturetechnology and then uploadedonto WebCT.

Entry requirementsApplicants should have a basicdegree in a related subject and/ora professional qualification andhave worked in the relevantsubject area for at least one year.We wish to include people fromdiverse backgrounds and careerpathways especially peopleworking in the independent andvoluntary sector and NHS. Forlanguage requirements, pleasesee the international studentssection on page 133.

Further informationDr Nasir Warfa, Tel: +44 (0)20 7882 2035email: [email protected]

How to apply


How to apply

All applications should be madeon an official application form.

Application methodsApplications should be made on the official application forms.There are two ways in which youcan apply for a postgraduateprogramme:

1) Apply online – using our onlineapplication form

This is our preferred method ofapplication.

Please go to our website forfurther details of how to applyonline:http://www.qmul.ac.uk/postgraduate/apply/index.html

2) Paper-based applicationYou will find an application forminserted at the end of thisprospectus. Please complete it carefully and return to theaddress at the bottom of the form.

If no application form is enclosed,or if it has been misplaced ordamaged, please contact theAdmissions and RecruitmentOffice for a replacement.

The application form can also beobtained from the Queen Marywebsite: www.qmul.ac.uk/postgrad/pgapplyq.shtml

The Admissions and RecruitmentOffice is happy to answer anygeneral application queries youmay have. If you would like moreinformation on programmecontent, then please contact theperson listed at the end of therelevant programme description.

To apply for researchprogrammes, please first contactthe relevant person in the Schoolin which you would like to study.

There are no closing dates forapplications to postgraduatestudy, although entry to someprogrammes is very competitiveand places may be full severalmonths before the start of theacademic year.

If you are concerned aboutprogrammes filling up and wouldlike advice on availability, pleasecontact the Admissions andRecruitment Office. Internationalstudents applying overseas maywish to contact one of ourrepresentatives in-country. See www.qmul.ac.uk/international/countries/ for more information.

Admissions contact detailsFreephone 0800 376 1800If calling from outside the UK:+44 (0)20 7882 5511 email: [email protected]

Tuition fees


Tuition fees

Undertaking postgraduate study is a serious commitment and involves careful financial planning at the timeof application and for the duration of the programme. Prices will almost inevitably rise and you must allow forthis when planning your finances. Your costs will comprise tuition fees and living costs.

The postgraduate fee rates for 2010/11 are as follows:

Advanced Mental Health Assessment PgCert £1,900 N/A N/A N/A

Aesthetic Surgery PgDip N/A £2,400 N/A £3,100

Analytical Toxicology PgDip N/A £3,200 N/A £13,100

Burn Care PgDip N/A £2,100 N/A £2,600

Cancer Therapeutics MSc £6,000 £3,000 £16,200 £8,400

Clinical Dermatology PgDip £3,600 N/A £4,600 N/A

Clinical Drug Development MSc £2,500 £2,500 £13,000 N/A

Clinical Drug Development PgDip £4,000 £4,000 £8,200 N/A

Clinical Microbiology MSc £8,200 £2,000 £13,200 £4,300

Clinical Microbiology PgDip £8,200 £2,000 £13,200 £4,300

Dental Clinical Services PgDip N/A N/A £14,990 N/A

Dental Clinical Services (Enhanced) PgDip N/A N/A £23,400 N/A

Dental Public Health MSc £9,500 £4,750 £14,990 N/A

Dental Technology MSc £9,500 N/A £23,400 N/A

Dental Technology PgDip £7,000 N/A £14,990 N/A

Dental Technology PgCert £4,750 N/A £7,495 N/A

Endocrinology and Diabetes MSc N/A £2,000 N/A £2,500

Endocrinology and Diabetes PgDip N/A £3,900 N/A £4,900

Endodontic Practice PgDip N/A £7,000 N/A N/A

Experimental Oral Pathology (Oral Sciences) MSc £9,500 N/A £14,990 N/A

Forensic Medical Sciences MSc £6,400 £3,200 £12,900 N/A

Gastoenterology (12 month) MSc £5,800 N/A £15,700 N/A

Gastroenterology PgDip £3,600 N/A £11,700 N/A

Gastroenterology (24 months) MSc N/A N/A £24,400 N/A

Health Care Research Methods MSc £2,500 £4,000 £13,300 N/A

Implant Dentistry MSc N/A £4,750 N/A N/A

Inflamation: Cellular and Vascular Aspects MRes £6,000 N/A £16,200 N/A

Mental Health: Psychological Therapies MSc £4,000 £2,000 £7,600 £4,900

Home/EU students Overseas students

Programme Level Full-Time Part-Time Full-Time Part-Time


Tuition fees

Mental Health: Psychological Therapies PgDip £3,000 £1,500 £5,500 £3,800

Mental Health: Transcultural Mental Healthcare MSc £4,000 £2,000 £7,600 £4,900

Mental Health: Transcultural Mental Healthcare PgDip £3,000 £1,500 £5,500 £3,800

Molecular Pathology and Genomics MSc £6,000 £3,000 £16,200 £8,400

Non Invasive Aesthetic Techniques PgCert N/A £2,500 N/A £3,000

Operative Gynaecology and Minimally Invasive Skills MSc £12,000 N/A £24,100 N/A

Operative Gynaecology and Minimally Invasive Skills PgDip £9,000 N/A £14,200 N/A

Operative Orthopaedic and Arthroscopic Skills MSc £12,000 N/A £24,100 N/A

Operative Orthopaedic and Arthroscopic Skills PgDip £9,000 N/A £14,200 N/A

Oral Biology MSc £12,000 N/A £24,000 N/A

Oral Medicine MClinDent £20,000 N/A £34,000 N/A

Oral Surgery MClinDent £20,000 N/A £34,000 N/A

Orthodontics MSc £20,000 N/A £34,000 N/A

Orthodontics MSc N/A £10,000 N/A N/A

Paediatric Dentistry Associate £15,000 N/A £34,000 N/A

Paediatric Dentistry MClinDent £20,000 N/A £34,000 N/A

Paediatric Dentistry MClinDent N/A £10,000 N/A N/A

Periodontology Associate £15,000 N/A £34,000 N/A

Periodontology MClinDent £20,000 N/A £34,000 N/A

Primary Care MSc £4,600 £2,300 £11,800 £5,900

Primary Care PgDip £4,200 N/A £11,100 N/A

Prosthodontics Associate £15,000 N/A £34,000 N/A

Prosthodontics MClinDent £20,000 N/A £34,000 N/A

Public Health MSc £4,600 £2,300 £11,800 £5,900

Sports and Exercise Medicine MSc £6,200 £3,100 £13,300 N/A

Sports and Exercise Medicine PgDip £4,800 £2,400 £11,700 N/A

Surgical Skills and Science MSc £12,000 N/A £24,100 N/A

Translational Neuroscience MSc £3,600 N/A £14,400 N/A

Translational Neuroscience PgDip £2,500 N/A £9,300 N/A

Translational Neuroscience PgCert £1,200 N/A £4,600 N/A

Overseas studentsHome/EU students

Programme Level Full-Time Part-Time Full-Time Part-Time

Please note that these fees are correct at the time of going to print, and may be subject to change. For part-time programmes the fee quoted is payable each year. For the most up to date fees, please seewww.qmul.ac.uk/tuitionfees


For a comprehensive list ofinternational tuition fees andscholarships, please see thewebsite:www.qmul.ac.uk/international/feesfinance

If you are in doubt as to whetheryou will be classed as an overseasor home student please consultthe Admissions and RecruitmentOffice at an early stage.

No additional charges are madefor registration, examinations, ormembership of the Students’Union. Additional costs will beincurred, however, in the followingcases:

• Students attending field orlanguage courses away from theCollege will be required to paypart or all of the cost

• Examination re-entry fees arecharged to students who are not in attendance

• Research students taking longerthan twelve months afterfinishing their research to writeup their thesis will becomeliable to pay a writing-up feeequivalent to the relevant part-time fee.

The Research Councils and manyother funding bodies pay feesdirect to the College. Studentswho are not sponsored by publicbodies, either in this country orabroad, are required to pay theirfees either before, or at the timeof enrolment at the beginning ofthe session.

Living costs andfunding your study


Living costs and funding your study

Living costsThe cost of living in Londondepends on your lifestyle.Typically, however, postgraduatesneed at least £11,000 to coverfood, accommodation, travel,books and so on for a full year (52 weeks), plus adequate fundsto maintain any dependants.International students will need toshow evidence of having at least£7,200 for living costs plus 100per cent of tuition fees in order toobtain Entry Clearance under Tier4 of the UK Border Agency’sPoints Based System ofimmigration. Additional amountsneed to be shown for dependants.£7,200 is based on nine monthsof study and is an immigrationrequirement only – most studentsrequire more money than this for12 month’s living costs – normallyaround £11,000. Please note thatwhile the College will offer adviceto students who encounterfinancial difficulties, it is not ableto fund postgraduate studentswho have started a programmewithout adequate or reliablefunding. Although hardship fundsmay be available, payments aresmall and cannot cover fees orcompensate for not havingadequate funding in place.

Funding your studyUnfortunately there are nomandatory awards forpostgraduate study, andalternative funding sources arelimited. Consequently it is vitalthat you consider how you will payyour fees and maintain yourself at

an early stage in the applicationprocess. All funding informationfor taught and research studentsis available on our website. Pleasevisit:www.qmul.ac.uk/postgraduate/feesfunding/index

Research students Possible funding sources toconsider include:

• Queen Mary, University ofLondon Research Studentships

• Research Council Studentships

• Career Development Loans

• Charities and Trusts.

Queen Mary, University ofLondon Research Studentships (Home, EU and Internationalstudents)The College offers a number ofresearch studentships each year,which are tenable for up to threeyears. The studentships covertuition fees and providemaintenance at the basicresearch council level (forguidance: £15,290 during the2009/10 session). Any applicantfor admission to an MPhil or PhDprogramme to commence in the2009/10 session will automaticallybe considered for a studentship,there is no separate applicationform. Details on the number ofstudentships available in eachdepartment can be obtaineddirectly from the department.

PhD studentships, including thoselinked to specific funded projectswithin the College, are advertised

on our website as well as thefollowing external websites:www.findaphd.com andwww.jobs.ac.uk

Research Council Studentships (Home and EU students only)These are the primary source of funding for Home and EUstudents and cover tuition feesand maintenance costs. They areavailable for research and someMasters programmes. Candidatesmust ordinarily be resident in theUK for a period of three yearsprior to the date of application(excluding any period spent infurther or higher education). Thestudentships are normally onlyavailable for candidates who haveobtained a first degree of goodhonours standard.



For further information aboutfunding via the respectiveResearch Councils please visittheir websites:

• The Arts and HumanitiesResearch Council (AHRC)www.ahrc.ac.uk

• Biotechnology and BiologicalSciences Research Council(BBSRC): www.bbsrc.ac.uk

• Engineering and PhysicalSciences Research Council(EPSRC): www.epsrc.ac.uk

• Science and TechnologyFacilities Council (STFC)(incorporating former PartclePhysics and AstronomyResearch Council (PPARC):www.scitech.ac.uk

• Economic and Social ResearchCouncil (ESRC): www.esrc.ac.uk

• Natural and EnvironmentalResearch Council (NERC):www.nerc.ac.uk

• Medical Research Council(MRC): www.mrc.ac.uk

To be considered for researchfunding from the researchcouncils, contact the relevantacademic department for detailson the application process. Mostof the research councils nowoperate schemes where QueenMary is given a set amount offunding and selects the studentsto whom this will be offered –prospective students do not applydirectly to the research council.

Professional and CareerDevelopment Loans (Home and EU students)Postgraduate students wishing toundertake certain programmes toenhance their careerdevelopment, who cannot obtainalternative funding, may borrow amaximum of £8,000 to cover 80per cent of tuition fees plus livingexpenses. Repayments aredelayed and the Government paysthe interest for the duration ofyour study and for one monthafterwards. Details are availablefrom the Directgov website(www.direct.gov.uk) andparticipating banks.

British Council Awards (International students only)A number of scholarships areawarded via the British Council’srepresentatives in an applicant’scountry of origin. This schemeoperates in approximately 70countries. The British Councilpublicises the awards and isresponsible for the selection of candidates. See:www.britishcouncil.org.

The British Council may also beable to give information on otherschemes operating in particularcountries.

Chevening Scholarships (International students only)This is a special scheme to fundstudy by individuals who areidentified as having potential tomake a particular contribution totheir country’s future.

For further details see:www.chevening.com/

China Scholarship Councilscholarships (International students only)Queen Mary Joint PhDScholarships with the ChinaScholarship Council. Available to students from China for PhDstudy in various areas. Under thisscheme Queen Mary, University ofLondon provides a scholarship tocover all tuition fees and theChina Scholarship Council (CSC)provides living expenses and onereturn flight ticket to successfulapplicants. Please refer to:http://www.qmul.ac.uk/international/scholarships/index.html#CSC

Queen Mary, University ofLondon – Bangladesh CapacityBuilding Scholarships (International students only)Queen Mary is keen to contributeactively to the development of thehigher education sector inBangladesh and is pleased toannounce the creation of twoQueen Mary, University of London– Bangladesh Capacity BuildingScholarships. Each of thesescholarships will provide fulltuition fees for full time MPhil/PhDstudy at Queen Mary in one of thefollowing areas: Biological andChemical Sciences, ComputerScience, Electronic Engineering,Engineering, Materials,Mathematical Sciences andPhysics.

For more information, see:www.qmul.ac.uk/international/scholarships/index.html


Or contact: Ms Runa NomanAlpha-i Consultants LtdHouse:99 (4th Floor) Road: 11/ADhanmondi R/ADhaka-1209Tel: 880-2-9111957 Mobile: 01712-018876; 01713-040100 email: [email protected]

Ms Angeliki PolatouThe Graduate Admissions OfficeQueen Mary, University of LondonLondon E1 4NSPhone: +44 20 7882 3080 email: [email protected]

Queen Mary, University ofLondon – Pakistan CapacityBuilding Scholarships(International students only)Queen Mary is keen to contributeactively to the development ofPakistan’s higher education sectorand is pleased to announce thecreation of two Queen Mary,University of London – PakistanCapacity Building Scholarships.Each of these scholarships willprovide full tuition fees for fulltime MPhil/PhD study at QueenMary in one of the following areas:Biological and Chemical Sciences,Computer Science, ElectronicEngineering, Engineering,Materials, Mathematical Sciencesand Physics.

For more information, see:www.qmul.ac.uk/international/scholarships/index.html

Or contact: Mr Nabeel VehraRegional Manageremail: [email protected]

Mr Mahmood Ur RehmanBusiness Development Manageremail: [email protected]

Queen Mary, University of London(Regional Office)Tel: +92 42 5692705 Fax: +92 42 5692706



Ms Angeliki PolatouThe Graduate Admissions OfficeQueen Mary, University of LondonLondon E1 4NSPhone: +44 20 7882 3080 email: [email protected]

Taught MastersstudentsThere are also some scholarshipsfor international students. Pleaserefer towww.qmul.ac.uk/international/scholarships/

AHRC(Home, EU only)For Arts and Humanitiesdisciplines only. Apply to therelevant academic department for details.

Westfield Trust Bursaries (Home, EU and Internationalstudents)A small number of Westfield Trustbursaries worth £2,000 areavailable each year to students on selected taught postgraduateprogrammes. Any applicant foradmission to one of the selectedprogrammes will be automaticallyconsidered for a bursary, andthere is no separate applicationform. Details are available fromthe Admissions and RecruitmentOffice from January each year.

College Postgraduate Bursaries (Home, EU and Internationalstudents)A small number of Westfield Trustbursaries worth £2,000 areavailable each year to students

on selected taught postgraduateprogrammes. Any applicant foradmission to one of the selectedprogrammes will be automaticallyconsidered for a bursary, andthere is no separate applicationform. International Students areeligible for the bursary, but willonly receive the equivalent of theHome/EU fee deducted from thetuition fee Details are availablefrom the Admissions andRecruitment Office from Januaryeach year.

Professional and CareerDevelopment Loans (Home and EU students)Postgraduate students wishing toundertake certain programmes toenhance their careerdevelopment, who cannot obtainalternative funding, may borrow amaximum of £8,000 to cover 80per cent of tuition fees plus livingexpenses. Repayments aredelayed and the Government paysthe interest for the duration ofyour study and for one monthafterwards. Details are availablefrom the Directgov website(www.direct.gov.uk) andparticipating banks.

Casual/part-timepaid work –earning while youstudyPostgraduate students are allowedto undertake part-time work, butthe hours you are able to work willbe constrained by the demands ofyour studies. International

students can work for up to 20hours a week in term-time andfull-time during the vacations.

We know that many students mayneed to supplement their incomewhile they study and we do ourbest to help facilitate this byoffering paid work. Queen Maryprovides various types ofemployment in vacation and termtime – from assisting withconferences to working in QMSU’sbar, cafés and restaurants.Postgraduates are oftenparticularly attracted to stewardingwork, where Collegeaccommodation on campus isprovided at a reduced rate inreturn for residential supervisionduties.

For more information aboutcatering or stewarding work,please contact:Student and Campus ServicesBusiness SupportTel: +44 (0)20 7882 8615/7669 email: [email protected]

All jobs offered by the Collegehave rates of pay that arecompetitive with other localemployers, and students can restassured that they will not beexposed to unsafe conditions,unreasonable hours or unpleasantworking environments. Furtherdetails are also available from theStudents’ Union.


Financial adviceand guidanceOur experienced Welfare Advisershave specialist training to offeryou professional advice on arange of financial issues. Our aimis to advise you about possiblefinancial solutions and options, sothat you can concentrate on youracademic progress. Most of ourwork is about helping you withyour rights and entitlements,including:

• postgraduate funding

• financial support for studentparents (childcare costs etc)

• fee status

• planning a budget

• dealing with debt

• welfare benefits and tax credits

• hardship funds

• funding from trusts and charities

• council tax

As well as helping you to findsolutions to problems, we can giveyou information and advice tohelp you to avoid problems beforethey happen. We can also giveyou advice before you start yourstudies.

For example, we can help you toplan a budget, and check that youare getting all the funding that youare entitled to. We can offer youadvice by telephone if you cannotattend in person:Tel: +44 (0)20 7882 8717www.welfare.qmul.ac.uk

Further informationIf you have any queries abouttuition fees or the scholarshipsand bursaries available throughQueen Mary, please don’t hesitateto contact us:

Admissions and RecruitmentOffice Queen Mary, University of LondonMile End RoadLondon E1 4NSTel: +44 (0)20 7882 5533email: [email protected]

International studentsand English languagerequirements


International students and English language requirements

English language requirementsAll tuition and examinations at theCollege are in English, so a soundcommand of the language isessential for success in anycourse of study, or when followinga research degree. Queen Maryprovides a number ofprogrammes in English foracademic purposes to helpinternational students get themost out of their study. You needto be able to cope with reading,note taking from lectures, books,journals and other materials; tospeak well in seminars,discussions groups and tutorials;and to present yourself effectivelyin written assignments andexaminations.

If your first language is notEnglish, you must provideevidence that your English skillsare sufficient by including withyour application details ofrecognised language qualifications

and experience in using thelanguage. The table below showsthe minimum English languagerequirements for each degreeprogramme.

Applicants who score slightlybelow the required IELTS bandmay be offered a place oncondition that they attend a pre-sessional English languagesummer programme. For furtherinformation seewww.languageandlearning.qmul.ac.uk/elss/presessional.

You will also be able to work onyour English language skills afteryou have arrived at Queen Mary.There are a number of classesoffering opportunities to practiceyour grammar and vocabulary,speaking and listening skills. For more information see:www.qmul.ac.uk/international/englishlanguagecourses/index.html

Academic study supportTo help students with thetransition to higher degree study,the Language and Learning Unitruns an programme of shortcourses, tutorials and drop-inclasses in such skills asorganisation and timemanagement, research and note-taking, oral communication andpresentation, academic writing,personal development planningand revision and examinationskills.

For more information aboutEnglish Language and AcademicStudy programmes contact:

English Language and Study Skills officeTel: +44 (0)20 7882 2827Fax: +44 (0)20 8983 5857email: [email protected]/elss

Aesthetic Surgery 7 610 253 100

Analytical Toxicology 7 610 253 100

Burn Care 7 610 253 100

Cancer Therapeutics 7 610 253 100

Clinical Dermatology 6.5 580 237 92

Clinical Drug Development 7 610 253 100

Clinical Microbiology 7 610 253 100

Endocrinology and Diabetes 7 610 253 100

Forenisic Medical Sciences 7 610 253 100

Gastoenterology 6.5 580 237 92

English language test scores

IELTS TOEFL CBTOEFL IBTOEFL


International students and English language requirements

Health Care Research Methods 7 610 253 100

Inflamation: Cellular and Vascular Aspects 7 610 253 100

Mental Health: Psychological Therapies 7 610 253 100

Mental Health: Transcultural Mental Healthcare 7 610 253 100

Molecular Pathology and Genomics 7 610 253 100

Non Invasive Aesthetic Techniques 7 610 253 100

Operative Gynaecology and Minimally Invasive Skills 6.5 580 237 92

Operative Orthopaedic and Arthroscopic Skills 6.5 580 237 92

Primary Care 7 610 253 100

Public Health 7 610 253 100

Sports and Exercise Medicine 6.5 580 237 92

Surgical Skills and Sciences 6.5 580 237 92

Translational Neuroscience 6.5 580 237 92

English language test scores

IELTS TOEFL CBTOEFL IBTOEFL

International studentsQueen Mary offers a cosmopolitangraduate community, withstudents from all over the worldmaking a valuable and activecontribution to academic andsocial life. Whether you havestudied in England before, orwhether this will be a newexperience for you, you will find awarm welcome at the College.

We offer a range of supportservices to help our internationalstudents feel at home.

Airport collection New international students areoffered a free airport collectionservice before the start of term inSeptember 2011. This service willbe advertised on our websitealong with an online bookingform: www.qmul.ac.uk/prearrival/

The welcome programme A welcome programme isprovided for all new internationalstudents before the start of termin September 2011. This is anopportunity to meet otherinternational students studying avariety of programmes and gainpractical advice about studyingand living in London.

Advice and counsellingThe Advice and CounsellingService offers professional adviceand support to internationalstudents throughout your timehere. We can advise you onfinance and funding, visaextension issues, immigrationrequirements, UK work schemesafter study, and offer counsellingsupport for personal/emotionalissues. We also organise a rangeof events through the year

especially for internationalstudents at Queen Mary. Asidefrom the welcome programme,these include various socialevents such as visits to other partsof the UK and informationsessions to help you make themost out of your time here. See:www.welfare.qmul.ac.uk

As a member of the internationalcommunity at Queen Mary, youwill automatically havemembership of InternationalStudents’ House (ISH) in centralLondon. ISH offers a wide rangeof services to internationalstudents including advice ontravel, accommodation and anextensive social programme. Fordetails of these and other servicesplease see the ISH website:www.ish.org.uk


HealthcareThere is a Student Health Serviceon campus. You (and your spouseand children if they are in the UKwith you as your dependants) areentitled to free medical treatmenton the UK National Health Service(NHS) if you are registered on aprogramme lasting six months orlonger. If your programme lasts forless than six months, you shouldmake sure you have adequatemedical insurance cover. If youare an EEA national, you shouldobtain a European Health

Insurance Card (EHIC) beforecoming to the UK, which entitlesyou and your family to full NHStreatment.

For more information, please visitour website:www.studenthealth.qmul.ac.uk

Representatives in your countryIn many countries we have officesor educational representatives,who you can visit to discussapplying to Queen Mary. Contactdetails can be found atwww.qmul.ac.uk/international/countries/

International OfficeMembers of staff at Queen Mary,regularly make visits overseas tomeet with students and academicinstitutions. For more informationon any aspect of life at QueenMary as an international student,please seewww.qmul.ac.uk/international/events or contact us:

International OfficeTel: +44 (0)20 7882 3066email: [email protected]/international

Campus life and accommodation



We are a campus university withseveral different campuses acrosseast and central London. Thelargest campus, at Mile End,houses most non-medicaldepartments, as well as excellentstudent accommodation.

The School of Medicine andDentistry is largely based at ourWhitechapel, CharterhouseSquare and West Smithfield sites.Next to The Royal LondonHospital, the Whitechapel campusis home to the impressive BlizardBuilding, which provides state ofthe art facilities for students andstaff with open-plan researchlaboratories, office space, alecture theatre and a café. Thebuilding also contains a uniqueinteractive science centre, Centreof the Cell, for local schoolchildren, parents and teachers.

Based in the City of London closeto the Barbican, the CharterhouseSquare and West Smithfieldcampuses are five minutes walkand on the site of StBartholomew's Hospitalrespectively. Charterhouse Squarehosts the Genome Centre, theWilliam Harvey Research Institute,the Institute of Cancer and theWolfson Institute of PreventiveMedicine. Dawson Hall, one of theCollege's halls of residence isbased here, as well as a studentbar, multi gym and squash courts.

AccommodationFinding suitable accommodationwhile studying at Queen Mary isrelatively easy. The College’s ownfacilities are both extensive andcompetitively priced. TheCollege’s Student Village is theonly self-contained campus incentral London. Allaccommodation is in self-cateredhouses, flats and maisonettes.Queen Mary students also haveaccess to places in the fullycatered Intercollegiate Halls incentral London, which are ownedby the University of London.Additionally, there is a range ofprivate sector housing in the eastLondon area surrounding thecampus. If you’d prefer to live in private accommodation, theCollege can help you find asuitable place, by providing youwith guidance notes and up-to-date listings of availableproperties. Please note, you needto be in London to commenceyour search, as pre-booking fromoverseas is not advised. Viewingthe accommodation andnegotiating a suitable contract isessential.

Once you have firmly acceptedyour offer to study at Queen Mary,full details of how to apply forCollege housing will be sent to you by the Admissions Office.

Some residences are reservedsolely for postgraduates, whileothers may be shared with finalyear undergraduate students; allresidences are for both male andfemale students. Single sex

accommodation is available in thenon-en-suite style of housing,subject to availability.

Rent scales and information The prices quoted relate toSession 10/11 and are reviewedannually.

Queen Mary Student Village and Halls of ResidenceRents for single rooms range from£88-£119 a week, inclusive of gasand electricity bills.Accommodation rents are payableeach term in advance and arereviewed annually. The licenceagreements are for a 38-weekcontinuous period from thebeginning of the academic year. If your programme continues overthe summer vacation period, youwill have the opportunity to extendyour licence agreement. We offerhousing between June andSeptember, subject to availability,but you may be required totransfer from your original hall ofresidence into another one.

University Intercollegiate Hallsof ResidenceAbout 200 Queen Mary studentslive in the University of London’sIntercollegiate Halls in centralLondon, alongside students fromother London colleges. Rents forsingle rooms are from £130 perweek, inclusive of breakfast,evening meals and all gas andelectricity bills.



Privately-rented accommodationOnce settled in London, manypostgraduate students prefer theindependent lifestyle offered bysharing flats or houses withfriends. The Residences Officecan provide advice, informationand up-to-date listings of privatelyowned accommodation availablefor rent. Information can also befound on individual room lettingsor homestay accommodation.

Family accommodationIf you have a family, we wouldstrongly advise you not to bringyour partner or children to live inLondon until you have securedsuitable, affordable housing.There is very little university orhostel accommodation forstudents with families, andhousing in the private sector canbe very expensive.

ContactFull details of the accommodationoptions for postgraduates can befound on our website.

Normal office hours are 9am-5pmthroughout the year, exceptweekends and UK Bank Holidays.

For all enquiries aboutaccommodation:The Residences Office Student and Campus ServicesQueen Mary, University of LondonMile End RoadLondon E1 4NSTel: +44 (0)20 7882 5522 email: [email protected]


Useful Queen Mary websites

You can find out more aboutstudent life at Queen Mary online.We’ve put together a list of themost useful websites below.

Advice and Counselling Servicewww.welfare.qmul.ac.uk

Disability and Dyslexia Service www.dds.qmul.ac.uk

Application formswww.qmul.ac.uk/postgrad/pgapplyq.shtml

Careers Servicewww.careers.qmul.ac.uk

Faithwww.faith.qmul.ac.ukwww.qm-mfc.co.uk

International office www.qmul.ac.uk/international/

Nurserywww.nursery.qmul.ac.uk

Occupational Health Service(OHS)www.ohs.qmul.ac.uk

Residential Services www.residences.qmul.ac.uk

Students’ Union www.qmsu.org

Student Health Servicewww.studenthealth.qmul.ac.uk

Other useful websitesGreater London Authoritywww.london.gov.uk

International Students’ House(ISH)www.ish.org.uk

The National Union of Students(NUS)www.nusonline.co.uk

Student Travel Association (STA)www.statravel.co.uk

Transport for London www.tfl.gov.uk

University of London Union (ULU)www.ulu.co.uk

Barts and The London School of Medicine and Dentistry

Programme index

Advanced Mental Health Assessment 118

Aesthetic Surgery 32

Analytical Toxicology 102

Burn Care 32

Cancer Therapeutics 46

Clinical Dermatology 33

Clinical Drug Development 102

Clinical Microbiology 33

Dental Clinical Services 63

Dental Public Health 63

Dental Technology 64

Endocrinology and Diabetes 103

Endodontic Practice 69

Experimental Oral Pathology 66(Oral Sciences)

Forensic Medical Sciences 104

Gastroenterology 34

Health Care Research Methods 102

Implant Dentistry 68

Inflamation: Cellular and Vascular Aspects 106

Mental Health: Psychological Therapies 118

Mental Health: TransculturalMental Healthcare 118

Molecular Pathology and Genomics 47

Non Invasive AestheticTechniques 36

Operative Gynaecology andMinimally Invasive Skills 48

Operative Orthopaedic and Arthroscopic Skills 49

Oral Biology 69

Oral Medicine 70

Oral Surgery 70

Orthodontics 71

Paediatric Dentistry 72

Periodontology 73

Primary Care 82

Prosthodontics 74

Public Health 83

Sports and Exercise Medicine 85

Surgical Skills and Science 50

Translational Neuroscience 36

140

Barts and the London School of Medicine and Dentistry141WWW.SM

D.QMUL.AC.U

K

Queen Mary, University of LondonMile End RoadLondon E1 4NSFreephone: 0800 376 1800

If calling from outside the UK: Tel: +44 (0)20 7882 5533Fax: +44 (0)20 7882 5588email: [email protected]

This guide has been produced by thePublications and Web Office for Barts and The London School of

Medicine and Dentistry - Pub6087

The information given in this prospectus is correct at thetime of going to press. The College reserves the right to

modify or cancel any statement in it and accepts no responsibility for the consequences of any such

changes. This prospectus has been printed on environmentally friendly material from sustainable

sources using non-solvent inks

Any section of this publication is available upon requestin accessible formats (large print, audio, etc.).

For further information and assistance, please contact: Diversity Specialist, [email protected], 020 7882 5585

barts and the london school of medicine and dentistry pg 2011.pdf

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