bacterial endonuclease
TRANSCRIPT
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E Antiviral medication
N D O V I R A Z A
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Endoviraza®
Trade name of the product
Bacterial endonuclease
International non-proprietary name
ENDOVIRAZA®
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Registration certificate
Declaration of conformity
License for implementation of pharmaceutical activity
ENDOVIRAZA® official documents
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ENDOVIRAZA® Competitive advantages
It is the only enzyme medication in the world having a direct virusocidal effect. It is non-toxic, non-aggressive, and nonreactive towards mucosal surfaces and skin. It does not contain iodine, chlorine and other substances toxic for animal organisms.
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Beekeeping
Poultry breeding
Livestock breeding
ENDOVIRAZA® animal groups and modes of its application
Horse breeding
In the form of fine aerosol
Intranasal with fine aerosol
Treatment with “cold fog”
Intranasal with fine aerosol
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= + ENDONUCLEASE Activity 50 000 units An excipient is polysaccharide dextran – 45 mg
ENDOVIRAZA® Presentation and content of bottles
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Activator – MAGNESIUM SULPHATE 0.62 g
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ENDOVIRAZA® against diseases of cattle
parainfluenza of cattle
adenoviral bronchial pneumonia of cattle
adenovirosis of cattle
infectious bovine rhinotracheitis
herpes of upper respiratory airway of cattle
shipping fever of cattle
viral respiratory infection of cattle
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ENDOVIRAZA® against diseases of horses
viral respiratory infection
infectious rhinotracheitis of colts
pneumovirus of colts
equine rhinopneumonia
parainfluenza of horses
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viral respiratory infection
avian metapneumovirus
pneumovirus of chickens
infectious laryngotracheitis of chickens
avian bronchial pneumonia
influenza, avian parainfluenza
avian infectious laryngotracheitis
avian bronchitis
Newcastle disease
ENDOVIRAZA® against poultry diseases
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acute and chronic paralysis filamentovirosis
sacbrood disease
egyptovirosis
deformed wing disease
viral diseases of bees
disease of forest honey flow
black disease
May sickness
viral paralysis
ENDOVIRAZA® against diseases of bees
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ENDOVIRAZA® Spring-and-summer stimulation of development
of bee families
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The mechanism of stimulation and development of bee families:
Elimination of latent (persistent) viruses inhibiting development of bee families.
Acceleration of decomposition of organic substances forming the basis of bee food.
Stimulating effect of the enzyme on larval bees and a queen (increase in egg laying).
Increase in the amount of brood – up to 25%
Increase in the amount of honeyflow – up to 50%
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ENDOVIRAZA® Molecular structure of endonuclease
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ENDOVIRAZA® Mode of action
Animals
Intranasal,
fine aerosol,
“cold fog”
Adhesion and deep
penetration
Hydrolysis till nucleotides
Active ingredient – Bacterial endonuclease Activator – magnesium sulphate
Mucosa of respiratory passages
RNA or DNA of the virus
Prophylactic action and treatment of viral diseases of upper respiratory airway
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ENDOVIRAZA® Mode of action
Bees
Fine-divided spraying within a bee family
Penetration into bee hemolymph
Wellness of a bee family
Active ingredient – Bacterial endonuclease Activator – magnesium sulphate
Protection of a bee family against viral diseases
Stimulation of development of a bee family
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Intranasal with fine aerosol for 30 heads
Curative treatment
Preventive care
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Endonu-clease
Magne-sium sulphate + +
50 000 activity units
62 mg
2.5 ml into each nostril, once a day
Periodicity of treatment - 4-5 times at the interval of 1-3 days
2.5 ml into each nostril, once a day
Periodicity of treatment - 2 times at the interval of 7-10 days
150 ml
The working solution retains its properties for 24 hours
Water
ENDOVIRAZA® Scheme of application
Horses and cattle
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Treatment with “Cold fog”
Curative treatment and preventive care
Recommendations
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Endonu-clease
Magne-sium sulphate + +
50 000 activity units
62 mg
15 ml of the solution for 1 m2 if floor-managed
15 ml of the solution for 1 m2 or 0.5 m3 if cage-managed
Periodicity of treatment of chickens (broilers) - 3 times at the interval of 3 days, beginning at 21 days-old
Periodicity of treatment of poultry (without vaccination) - 5 times at the interval of 2 days, since their first days of life
Length of a blow-off body is 5 -10 meters
Height of a sprayable layer is at least 40 sm above the ground
Size of sprayable particles is from 5 to 15 microns
500 ml
The working solution retains its properties for 24 hours
Water
ENDOVIRAZA® Scheme of application
Poultry
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Treatment of 10 bee families in the form of fine aerosol
Curative treatment
Recommendations
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Endonu-clease
Magne-sium sulphate + +
50 000 activity units
62 mg
Each beeway should be sprayed with a dose of 4-5 ml for 2-3 seconds
for one bee family (10-12 standard frames) is 40-50 ml
Periodicity of treatment - up to 7 times according to indications at the interval of 7-10 days
In a spring-summer period at an air temperature above 14оС
In the morning (before bee flight) or in the evening (after bee flight)
500 ml
The working solution retains its properties for 24 hours
Water
ENDOVIRAZA® Scheme of application
Bees. Curative treatment
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Treatment of 10 bee families with a solution in the form of
fine aerosol
Preventive care
Recommendations
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Endonu-clease
Magne-sium sulphate + +
50 000 activity units
62 mg
Each beeway should be sprayed with a dose of 4-5 ml for 2-3 seconds
for one bee family (10-12 standard frames) is 40-50 ml
Periodicity of treatment - at least 3 times at the interval of 7-10 days
In a spring-summer period at an air temperature above 14оС
In the morning (before bee flight) or in the evening (after bee flight)
For better over-wintering of diseased families, they are treated once at the end of the summer season before family gathering
500 ml
The working solution retains its properties for 24 hours
Water
ENDOVIRAZA® Scheme of application. Bees
Stimulation of development and preventive care
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ENDOVIRAZA® Safety of application
Side effects and complications are absent
Peculiarities of action of this medication at the time of its first application or cessation are absent
When applying of this medication, symptoms of its overdose are absent
This medication is compatible with other drugs and feed supplements
Products obtained from animals that have been treated with this medication can be used without any restrictions
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Thanks for your time!
Contact details – OOO “Severniy stil” Location: 109202, Moscow Postal address: 630049, Novosibirsk, Krasniy prospekt, 153B, office 32; Phone: +7 916 656 5050 (English)
Manufacturer – JSC “Pokrov Biological Plant” Volginskiy, Petushinskiy Region, Vladimir Oblast., 601125, Novosemenkovskaya street