Awake Animal SPECT: Overview and Initial Results

OAK RIDGE NATIONAL LABORATORY

U.S. DEPARTMENT OF ENERGY

U.S. DEPARTMENT OF ENERGY

Drew Weisenberger1, Brian Kross1, Stan Majewski1, John McKisson1, Vladimir Popov1, James Proffitt1, Sasha Stolin1, Justin Baba2, Jim Goddard2, Mark Smith4,Ben Tsui3 and Martin Pomper3

1Thomas Jefferson National Accelerator Facility, 2Oak Ridge National Laboratory, 3Johns Hopkins University, 4University of Maryland.

SPECT camera

Infrared Tracking System

Awake Animal SPECT-CT Imaging System

An awake mouse with infrared reflectors for head tracking shown in imaging burrow.

Computer display illustrating real-time pose tracking via the stereo infrared CCD cameras.

SPECT camera

SPECT camera data and voltage cables

• Accommodate analog signals from two gamma cameras • Need to incorporate time stamp event by event• Software controlled high voltage to gamma cameras• Elimination of long signal wires by employing fiber optic USB2 repeater

SPECT Data Acquisition System Modifications

SPECT cameras

JLab FPGA data acquisition system

USB-fiber optic

Infrared Tracking System

mouse in burrow

Tc99m-MDP

SPECT Scan of Awake Mouse

Movie of Multiple SPECT Projections