avian influenza role of bio security

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    AVIAN INFLUENZA:Role of Biosecurity

    Dr.Kedar Karki

    M.V.St.Preventive Veterinary

    Medicine

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    Avian Influenza

    A Viral disease of Domestic and Wild

    Birds characterized by the full range of

    responses from almost no signs of thedisease to very high mortality. The

    incubation period is also highly variable,

    and ranges from a few days to a week(3 to 7 days).

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    Etiology of Avian Influenza

    Influenzavirus A genus of theOrthomyxoviridae family.

    They are enveloped, negative strandedRNA viruses.

    Influenza A viruses can be divided into15 Haemagglutinin (H) antigens. 9Neuraminidase (N) antigens.

    Extreme antigenic variability broughtabout by genetic reassortment in hostcells.

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    Influenza Viruses

    2 Pathotypes:

    HPAI LPAI

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    Ecology of Avian

    Influenza Viruses

    The greatest variety of Avian Influenzaviruses has been isolated from wild birds,particularly from waterfowls.

    Serve as reservoirs and gene poolsThese birds perpetuate only viruses of low

    pathogenecity

    Natural host of AI viruses to which theviruses are well adapted.Waterfowls are resistant to the disease

    induced by HPAI viruses.

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    Ecology of Avian Influenza

    VirusesDomestic Poultry does not appear to be

    the natural host of these viruses, thereforethe degree of adaptation to the host is low

    and this could possibly explain why

    documented virus mutation has virtually

    always occurred in domestic poultry

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    Highly Pathogenic Avian Influenza

    Worldwide Occurrences

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    Recent News

    Indonesia: Poultry Disease OutbreakDevastating Regional Sector. An article in the Jakarta Post on Dec. 18:

    Many poultry farmers forced out of business in theface of the current outbreak of ND. A spokespersonfor 1 of the Sleman and Kulonprogo Regency districtsector said: Out of 25 members of the neighborhood

    unit, only 3 still have chickens. The others birds areall dead. He added that only 25 % of farmers in hisarea are still operating. The virus had also spread toother areas of the regency. Some estimates suggest

    that a number of district have lost up to 80 % of theirpoultry

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    South Korea Latest Developments

    The Government is doing its best to support the

    industry but public are not buying poultry or eggsdespite assurances that this form of AI does notpose a health hazard.

    First confirmed case of bird flu Dec. 15, 2003:49 suspected farms14 cases confirmed positive for AI

    7 cases are from ducks1 from broiler breeder

    2 from broilers4 from layers

    17 cases were negativeThe other 18 farms are being tested

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    Taiwan Latest Developments

    Taipei (Reuters, Jan 5,2004) Taiwan

    reported its first case of a highlycontagious bird flu Wednesday (Dec.

    31,2003), but said six ducks smuggled

    from mainland China that had tested

    positive (H5N1) had been destroyed.

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    Avian Influenza

    Differential Diagnosis

    Infectious Bronchitis

    TRT/APV Newcastle Disease

    Respiratory viruses Mixed

    infections

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    Avian InfluenzaDiagnosis

    1. Clinical Signs

    2. Virus Isolation andCharacterisation

    3. Serology

    4. PCR

    5. Histopathology and

    Immunochemistry

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    3 Categories of TransmissionIntercontinentalTransport of live poultry, frozen poultry meat and

    untreated hatching eggs over long distances.Trade of poultry by-products unheated and eggproducts and possibly frozen poultry semen.Least importance are free living migrating birds

    InternationalTrade of commercial poultry including live birds,

    vehicles, crates, containers. Also, internationalexhibitions, shows, bird markets and similarevents. Least important are birds which displays

    seasonal migration pattern.LocalFarm personnel, technical crew (debeaker,

    vaccinators, catchers, etc.). Also, contaminated

    poultry manure and waste stuff as well asairborne particle and dust. Significant are live

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    BIOSECURITY

    DEFINITION : all procedures used to

    prevent the introduction of disease

    OBJECTIVES :

    - prevent the entry of disease

    - control the spread of disease

    BIOSECURITY IS EVERYONESRESPONSIBILITY!

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    BENEFITS OF BIOSECURITY

    HELPS KEEP OUT diseasesREDUCES THE RISK of zoonotic diseasesLIMITS THE SPREAD of diseasesHELPS PROTECT the public healthIMPROVES the overall flock healthCUTS COSTS of disease treatmentREDUCES LOSSES and improves

    profitability

    BETTER BIOSECURITY PROVIDES : Peace

    of mind, a healthier flock and a more

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    HOW DISEASES SPREAD

    MOVEMENT of people, animals,

    equipment, vehicles

    CONTACT with neighboring flock

    CONTACT with insects, rodents, stray

    animals and pets

    CONTAMINATED water & feeds

    INADEQUATE cleaning and disinfection

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    BIOSECURITY INFORMATION

    STRICTLY limit and control access to thefarm fencing w/ a controlled entry point

    KEEP an all-in, all-out flock management

    PROVIDE a security or decontaminationarea

    REQUIRE all persons entering the farm tosign a visitors logbook; vehicle platenumbers must also be recorded

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    BIOSECURITY INFORMATION

    CLEAN & DIRTY areas should be well-defined

    THOROUGHLY clean and disinfect all

    equipment & vehicles entering AND leavingthe farm

    BETTER NOT to borrow equipment or

    vehicles from other farms

    DONT USE same vehicles for transporting

    birds, feeds, equipment or waste products

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    BIOSECURITYINFORMATIONCLEAN, PROTECTIVE clothing and

    footwear must be worn in the farmHAVE a designated cleaning & disinfecting

    area

    WHEN DISINFECTING, remove all dirt &solid matter first Dirt & manure cannot bedisinfected!

    KEEP the farm surroundings clean & tidyFOOTBATH must be provided in every

    poultry house; footbath should be kept clean

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    BIOSECURITY INFORMATION

    KEEP WILD BIRDS off the poultry houses bird-proofing

    KEEP other animals, pets or other livestock

    out of the farmPEST & RODENT control programPROPER DISPOSAL of damaged eggs,

    dead birds, litter or manureREGULARLY clean & disinfect all

    equipment & vehicles before and after use

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    BIOSECURITY INFORMATION

    AFTER EVERY CYCLE, thoroughlyclean & disinfect all houses &equipment

    ONCE CLEANED, a farm should beclosed & left idle; the longer the downtime, the better the results.

    IMPLEMENTING A STABLE

    BIOSECURITY PROGRAM IS INDEEDAN EFFORT WORTH MAKING!

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    INI MUM BIOSE CURI TYSTANDA RDS

    No Visitors A sign-in log

    Clean clothing and sanitized footwear Properly maintained foot pans with

    disinfectant solution Rodent and insect control

    No other animals, esp. wild birds Vaccination All in, all out

    Sanitize hands

    IMPORTANT

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    IMPORTANT

    REMINDERS

    MAKEa flock health plan that includes basicbiosecurity measures

    ENSUREthat all records are accurate & up-

    to-dateALLpoultry personnel should be trainedLOOK OUTfor signs of disease early

    detection is key!REPORTimmediately if disease is suspected

    BE VIGILANT!

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    Reminders

    Effective Bird ProofingWorking Pest Control Program

    For Rodents and Fly

    No other animals especially waterfowl

    Sign in Log Book

    Power Sprayer at the farm gate

    Separate foot wear/Foot Dip

    Sanitation/disinfection

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    Prevention

    Surveillance / Monitoring

    Vaccination

    Biosecurity

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    Control

    BiosecurityQuarantine Intensify disinfecting measures

    Monitoring/SurveillanceStamping Out / DepopulationDIVA Vaccination - only for LPAI and

    not for HPAI because it might prolongthe shedding of the virus

    Proper Disposal