1108

AUTHOR INDEX

Abbott, Frank S., 1038Abdollah, Hoshiar, 846Abemethy, D. R., 180Athchi, Hideki, 245Adams,WadeJ., 527Aldrich, W., 429Al-Habet, Sayed M. H., 55

Allen, Richard C., 779Allenby, Susan M., 613

Alonso, I. G., 732

Amacher, David E., 659Anders, M. W., 50

Anderson, D. J., 441

Andrews, Allen F., 680Anliker, Sally L., 968Aoyama, S., 409Aoyama, Toshifumi, 383

Apseloff, Glen, 298Arai, Masayuki, 264Arison, B., 476Arison, Byron, 203

Armstrong, Paul W., 846Arnaud, Maurice J., 327Astoin, Jacques, 794Aungst,BruceJ., 288

Bach, Mostafa Z., 654Baillie,Thomas A., 527, 794

Baker,MaxT., 753Balfour, Celia, 168Barker, R., 435

Bar-On, Hanoch, 238Bates,JamesN., 753

Bauer, Carlo, 551Beattie,I., 146

Beck, W. S., 962Bend, John R., 1031

Benet, Leslie Z., 292, 639Berghmans, M. C. J., 999Bertrand, Marc, 804

Bevan, Rae, 369Bevill, R. F., 626Bezek, �tefan, 88, 96, 378Bialer, M., 571Bialer, Meir, 238Bienvenu, Thierry, 327Biglino,G., 771Billig, Hanna, 238

Billings, Ruth E., 304

Birch, D. W., 534Birkett, Donald J., 356Birnbaum, Linda S., 494

Birnbaum, L. S., 866Bjercke, Robert J., 759Blair, Ian A., 28Blake,T.J., 146Bock, K. W., 720Bockx, M., 704Boje, Kathleen M., I 27Bonati, Maurizio, 102Bonfils, Claude, 711

Bopp, B. A., 441Bortolotti, Angela, 102

Brashear, Wayne T., 488Brazzell, R. K., 435Bredberg,U., 338Brendel, K., 514Brennan, F. James, 846Brien, James F., 846Brocks, Dion R., 471

Brodfuehrer, Joanne I., 20Broly, F., 362Bromet, Norbert, 804Brouwer, Kenneth, 1084Brouwer, Kenneth R., 1078

Brouwer, Kim L. R., 197

Brown, N. K., 548, 1065Brown, S. Y., 546Brune, K., 962Brune, Kay, 939Brunner,LaneJ., 158

Buckpitt, Alan, 183Buonarati, Michael, 183Burka, L. T., 866Burnette, Thimysta C., 315

Caldwell, John, 115Callaghan, John T., 968Capello, S., 190Caputo,O., 771Castagnoli, Jr., Neal, 418

Cats, H. A., 954

Cavanaugh,J.H.,441Cederbaum, Arthur I., 393

Ceruti, M., 771Chages, V., 692Chambers, Mark A., 298Chang, Ann S., 686Chang, Tsun, 980Chapman, Dennis E., 929

Chauvelot-Moachon, Laurence,467

Chen, Di, 276

Chen, 1-Wu, 138, 836Chen, Theresa S., 882Chen, Tian-Ling, 815

Chenery, Richard J., 613Chenery, R. J., 146Chesson, Susan M., 779

Chiang, Chao-Kuo, 753Cho, Arthur K., 686Chong, S., 61

Christ, D. D., 1Clejan, Liviu A., 393Cleveland, Patricia, 72Colby, H. D., 543Colvin, 0. Michael, 815Constable, DebOrah A., 726

Cook, Chyung S., 42Coon, Minor J., 742Cooper, John K., 735

Copeland, Kenneth, 226Couch, R., 435Cousins, Michael J., 819

Cox, Jeffrey W., 726Cox,P.J., 146

Cretton, Erika M., 369Cribb, Alastair E., 784Cros, Suzie, 895Crouch, Ronald, 321Cumin, F., 831Cuvier, Gerard, 794

Dalet-Beluche, lsabelle, 711Damais, Chantal, 467

Daniel, Mick J., 1092

d’Athis, Philippe, 327Daugaard, Henrik, 231

deGasparo,M., 831

DeGrazia, F., 190

Dekant, Wolfgang, 911

deLuna, F. A., 388

deLuna, Florencia A., 484

Demby, Karen B., 197

de Miranda, Paulo, 315, 321DeSante, Karl A., 968Dey, M., 429de Zeeuw, R. A., 923

Dhahir, Patricia H., 968Dickinson, T. H., 180

Dietzel, K., 962DiLeo, Eva M., 779Diliberto, Janet J., 494

Diliberto,J.J., 866

Dimov, Vladimir, 107Ding, Xinxin, 742

Distefano, Emma W., 686Domergue, Jacques, 595

Donahue, B. S., 519Drenth, B. F. H., 923Dring, L. Graham, 726Duggan, Daniel E., 203, 218, 836

Duggan,D.E., 138,476

Duncan, A. E. W., 388Duncan, C. A., 138, 476

Durisov#{227},Maria, 96

Egtjord, Martin, 231

El Dareer, S. M., 842Elfarra,AdnanA.,917Endo,H.,212

Enever, R., 429Engler, H., 962Evans, Gary L., 1092

Fabre, Gerard, 595Fabre, Isabelle, 595, 7 1 1Feng, Paul C. C., 373Ferguson, Ronald J., 680Fermoso,J., 732Fernando, J., 514Ferrero,J.L.,44lFilla, Mark S., 175

Fleckstein, L., 281Flesher, James W., 163, 664

for, S. C., 1103Fong, Ho-Leung, 61

Forkert, P. G., 534Forti, Giorgio Cantelli, 551

Foth,H., lOll

Franz, Paula M., 968Fuhr,U., 1005Fujihara,M.,2l2Fujita, Shoichi, 812Fukuda, E. K., 546Fukushima, Kiyomi, 264

Funae, Yoshihiko, 943Fung, Ho-Leung, 127

Gar#{234}s,Mich#{232}le,895Garland, W., 190Garland, W. A., 546Gasinska, Izabella, 588Geary,R.S.,281

Geddes,B.A., 534Gehret, John R., 836Geisslinger, G., 962Gelboin, Harry Y., 383

Gele, Patrick, 804Gerber, Nicholas, 298

Gerding, T. K., 923Ghantous,H.N., 514Gilet, Gerard, 711

Gillette, James, 383Gillette, James R., 557, 974Ginsberg, Leonard C., 726

Giroud, Jean-Paul, 467Glass,S.J., 551Gmur, Denny J., 68Gondolfi,A.J., 514

Gonzalez, Frank J., 383

Good,StevenS., 315,321Graden, D. W., 949Green, Krister, 107Gregus, Zoltan, 10Grislain, Luc, 804Grosa,G., 771Gu#{232}nard,Daniel, 895Gu#{232}ritte-Voegelein, Fran#{231}oise,

895

Guilt, Peter R., 42Gupta, Samir, 42

Hakusui, Hideo, 698Halpert, James, 168Halpin, Rita A., 203Haistead, Gordon W., 527Hammond, Dianne K., 759Hanano, Manabu, 121

Harder, S., 1005

Harrington, G. W., 626Harvey, D. H., 571

Harvey, D. J., 350, 548, 1065Hasegawa, Takaaki, 565Hasinoff, Brian, 344Haughey, David B., 403Hem, David W., 680Hekster, Yechiel A., 852Held, Sara D., 5Hellkamp,J., lOll

Henderson, L., 190Hendrickx, J., 704

AUTHOR INDEX 1109

Heur, Young-Hun, 447Heykants, J., 704Hichens,Martin, 1025

Higgins, Catherine V., 659Hill, D. L., 842Hiramatsu, Masayuki, 686

Hirayama, Hiroki, 580, 588Hisaka, Akihiro, 621Hoffman, William F., 203Holder, Claude L., 1018

Honcharik, Nicholas, 226Hoogenboom, L. A. P., 999

Horn, A. S., 923Howard, M. 0., 607

Hrabie, Joseph A., 447

Hsieh, J. H., 388Hsu, Robert S., 779Hubbard, John W., 735, 1096

Huelle, B. K., 281Hultin, Theresa A., 175

Hurkmans, R., 704

Hurle, A. Dominguez-Gil, 732Hurst, Harrel E., 276, 504Hussain, Munir A., 288Hutchison, Michael, 613Hwang, In Young, 917

Ichimura, Fujio, 258

Imaoka, Susumu, 943Ishiguro, Masaji, 245

Ishikawa, H., 212

Jajoo, Hemant K., 28Jamali, Fakhreddin, 471James, Margaret 0., 552

Janssen, C., 704Jaw, John-Yan, 168Jenden, Donald J., 686

Jenner, Mark A., 819

Jimmo, Sandra, 846Johno, Ikuo, 565Johnson, John T., 992Johnson, M. J., 441Johnson, Robert L., 321

Jones, A. Daniel, 183Jones,JamiA., 197Juedes,Marlenei., 131Jusko, William J., 403

Kagoshima, T., 212Ka1i1,G.F., 1011Kaiser, David G., 527K#{227}llay,Zolt#{225}n,88

Kamata, K., 409Kaminsky, Laurence S., 168

Kamoun, Annie, 804Kanao, Munefumi, 698Kari, H. P., 476

Kari,PrasadH., 203,218, 1025

Karim, Azii� 42Kasamatsu, Satoe, 621

Kato, Hideo, 902

Keefer, Larry K., 447Kelly,DanielW., 1018

Kemper, C. J., 746Kemper, Ray, 504Kenna, J. Gerald, 788

Keohane, D. J., 607

Kerr, Bradley M., 540

Kimmel, H. B., 746

Kinns, M., 1100Kirlin,WardG.,680

Kitani, Kenichi, 812Kitazawa, Shikifumi, 565Klaassen, Curtis D., 10Klunk, Lewis J., 153Knuckle, Leali C., 1031Koble, Cecilia S., 321Kolmer, Eleonora W. J. Beneken,

852Komatsu, K., 212

Koob, Michael, 911Korchinski, Elarien D., 735

Korfmacher, Walter A., 1018

Korzekwa, Kenneth, 383Korzekwa, Kenneth R., 974Kowalski, Ken, 42Kozeniauskas, R., 626Kravchenko, L. V., 223Kuhnert, Betty R., 488Kuiper, H. A., 999Kukan, Mari#{227}n, 88, 96, 378Kumagai, Yoshito, 462Kumar, Rakesh, 735

Kunellis, E.-M., 1011Kupfer, David, 131Kurata, Norimitsu, 504Kuzmina, E. E., 223Kuzuya, Takafumi, 565

LaBudde, John, 28

Lafaurie, C., 692Lagarde, Jeanne, 1078Lamm, J. E., 441Lanao,J.M.,732

Lang,CalvinA., 882

Langone,JohnJ., 759

Lapka, Roman, 1060L.arson, Philip G., 726Lash, Lawrence H., 50

Lau, David T.-W., 292Laupattarakasem, Pisamai, 356Lauwers, W., 704

Lavrijsen, K., 704Lee,HenryJ., 55Lepage, Francis, 794

Levin, Wayne, 824Levine, Walter G., 36Levy, Ren#{233}H., 540Lhermitte, M., 362

Liberato, D., 190Libersa, C., 362Lin, J. H., 388

Lin, Jiunn H., 268, 484, 836Lindstrom, T. D., 674Linville, Anastasia R., 779

Liu,S.S., 1071Lloyd, J. R., 949

Lohr, D. P., 543Ludden,T.M.,281Luijten, Wim, 804Luke, David R., I 58Lukowski, Michael, 226

Macrae, P. V., 1100

Madhu, Cherukury, 10

Magdalou, J., 692Magee, P. N., 626Mangold, D. J., 281Mariel, Eric, 895Marrero, Diana, 153Marsh, K. C., 441

Martin, Billy R., 1046Martin,BrianM., 557

Martin, Jackie L., 788Martin, M. I., 732

Mason, William D., 654, 670

Massey, T. E., 534Mateos, A., 732

Matsunaga, Tamihide, 383, 943Maurel, Patrick, 595, 711

Mayol, Robert F., 28

Mays, Dennis C., 298McClanahan, Robert H., 373McCormick, David L., 175

McCue, B., 435McDonagh, Antony F., 639McKay, Gordon, 735, 1096McMahon, Timothy F., 494McManus, Michael E., 356Mehvar, Reza, 987

Meier, G. Patrick, 68Meuldermans, W., 704Michener, Sandra R., 929

Mico, Bruce A., 447

Midha, Kamal K., 735, 1096Migdalof, B. H., 253Miller, M. A., 281

Miller, Natalie E., 304Miller, Paul S., 815Miners,JohnO., 356

Miura, Iadayoshi, 852Miwa, Gerald T., 1078, 1084, 1092

Monsarrat, Bernard, 895Montague, Terrence J., 1055Moore, Tracy J., 929Morgado, John, 588

Morgan, Edward T., 649Morgan,E.T., 519Morris, Marilyn E., 809

Morrison, R. A., 253Mosher, Susan J., 1055Mourad, Georges, 595Mpezo, Mandi, 680Mulder, Gerard J., 270Murata, Mitsuo, 902Murata, Ryo, 403

Murphy, Joan S., 203Mutlib, Abdul E., 309, 331, 1038

Myers, Steven R., 163, 664

Myers, Timothy G., 765

Nadai, Masayuki, 565

Nagata, Kiyoshi, 383, 557, 974

Nagata, Osamu, 902Nakashima, Emi, 258Nanavati, Nitin T., 645Narimatsu, Shizuo, 943Nawoot, Sopone, 298Nelson, D. R., 626Nelson, Rita M., 50Nelson, Robert L., 968

Nelson, Sidney D., 765Nelson, Wendel L., 309, 331

Nerland, Donald E., 958Newton, J. F., 607Nims, Raymond W., 447Nishihara, Tatsuro, 245Noguchi, Teruhisa, 245Norman, Catherine A., 649Norman, S. J., 146Nuemberg, Bernd, 939

Oatis, Jr., J. E., 1

Obach, R. Scott, 508Ogolla, Fredrick, 680Ohannesian, Lena, 447Ohnuma, Norio, 245Ohtawa, Masakatsu, 621Oldfield, Neil, I 105Oklham,H.G., 146Olgaard, Klaus, 231

Olive, Georges, 327Olson, Michael J., 992Ono, Kenji, 698

Ono, Makoto, 852Oppermann, James, 42

Osborne, Peter M., 613

Overstreet, D., 866

Paalzow,L., 338

Pang, K. Sandy, 270, 580, 588

Paolini, Moreno, 551

Park,SangB., 68

Park, Y. H., 435

Parkinson, Andrew, 974

Parry, P. Simon, 1092Passerini, Flavio, 102Patanella, James E., 373, 1084,

1092

Patanella,Jim, 1078Pederson, Thomas C., 992Peterson, A. E., 253

Philpot, Richard M., 398Pichard, Lydiane, 595, 711

Pierce, Jr., William M., 276, 958

Piotrovskiy, Levon B., 88, 96, 378Pitzenberger, S. M., 476Pitzenberger, Steven M., 203, 1025

Plakas, Steven M., 552Plummer, John L., 819Pocetti, D. A., 253

Pohl, Lance R., 788

Pollack, Gary M., 197Pons, Gerard, 327Po#{252}s,Christian, 467Powis, Garth, 20, 929Prakash,ShimogaR., 218

Prakash, S. R., 476Probst,A., 831

Pue, Martin A., 613

Pullen,F.S., 1100

Pylypiw, Jr., H. M., 626

Quails, Jr., C. W., 607

Quigley, S. C., 441Quilliam, Michael A., 1055

Raichvarg, Denis, 467

1110 AUTHOR INDEX

Ramjit, Ham G., 203, 1025

Ramjit, H. G., 476

Raschdorf� F., 831

Rashed, Mohamed S., 765, 794

Ray, Gene F., 654Reidy, Charles A., 992Rejhole, V#{225}clav,1060

Rey, Elisabeth, 327Richard, Marie-Odile, 327Richert, P., 831Richie, Jr., John P., 882

Richter, Elmar, 398Rickert, Douglas E., SRideout, Janet L., 321

Rocco, F., 771

Rose, L. M., 842

Rosegay,A., 138Ross,DerekA., 613Rowe, Susan M., 288Rubin, Alan, 968Ruenitz, Peter C., 645Russell, John W., 153Ruterbories, K. J., 674

Saint Aubert, Bernard, 595Salvadori, Catherine, 804Samara,E., 548,571

Sanchez-Barona, D. 0. T., 281Sanders, S. W., 441Sandri, R., 1071

Sangalli, Lorenzo, 102

Sanins, Susan M., 527Sasame, Henry A., 557Sato, Hitoshi, 245, 902

Satoh, Hiroko, 788Satoh, Tetsuo, 264

Saverino, C. M., 607Scatina,J.A.,746

Schmid, K., 831Schneider, H. Thomas, 939Schnell, C., 831

Schrenk, D., 720

Schulze, Johannes, 398Schwartz, L. W., 607Schwartz, Michael S., 203

Schymanski, P., 1005Semmes, Robin L. 0., 80Shah, Jaymin, 670Sheffels, Pamela R., 447Shen, Danny D., 80Shen, Yu-Zen, 121

Shenvi, Ashok B., 288Shepard, Dale R., 298

Shepard,TeresaA., 613Shigenaga, Mark K., 418Shimoda, Minoru, 852

Shu, Yue-Zhong, 735, 1096Shutske,GregoryM., 779

Siest, G., 692

Singhvi, S. M., 253Sisenwine, S. F., 746Slatter, J. Greg, 1038

Slikker, Jr., William, 1018Smith, D., 429

Smith, Philip C., 639Smolarek, Teresa A., 659SmolIk, Stanislav, 1060

Sommadossi, Jean-Pierre, 369Sonders, R. C., 441Spielberg, Stephen P., 784

Srinivas, P., 866StaatS,D.A., 543

Staib,A.H., 1005

Standring, P., 146St. Claire, Robert L., 1078Stefek, Milan, 88, 96

Stiff, Dwight D., 888Stoddart, Albert M., 36Stokker, G., 476

Streeter, Anthony J., 447Strobel, Henry W., 759Strolin-Benedetti, Margherita, 1 15

Struck, R. F., 842Sugiyama, Yuichi, 121Suwa, Toshio, 264

Suzuki, Tokuji, 812

Swinney, David C., 859Swynnerton, N. F., 281

Szczepan, Edward W., 1031

Szelenyi, Istvan, 939

Takaiti,O., 212Takegoshi, Toshio, 698

Takenaga, Norihiro, 621Talaat, Rasmy E., 1038

Tamai, Ikumi, 245

Tanaka, Makoto, 698Tang-Liu, D. D. S., 1071Taraporewala, Irach B., 55

Tarbit,M.H., 1100Tatsumi, Kiyoshi, 876Tatsuno, Jun, 812

Tepper, P. G., 923

Terasaki, Tetsuya, 902

Teunissen, P. C., 954Thenot, Jean-Paul, 71 1

Thliveris, James, 226Thomas, Brian F., 1046Thomas, David, 304

Thurmon, J. C., 626Tillery, K. F., 842TOcCO,D.J., 388Tocco, Dominick J., 484Todaka, TakaShi, 462Told, Satoshi, 462

Tolman, K. G., 441Town,C., 190Trager, William F., 974

Trinidad, Alma, 680Trnovec, Tom#{225}�, 88,96

Trooster, J. F. G., 954

Tsao, 5.-C., 180Ts’o, Paul 0. P., 815Tsuji, Akira, 245, 902Tutelyan, V. A., 223

Ueda, Clarence T., 72

Ulm, Edgar H., 203, 484, 836

Ulrich, Roger G., 726Umehara,M.,212Unger, Steve E., 1084, 1092Usha, G., 866

Vadiei, Kiumars, 158Van Dyck, D., 704Van Dyke, Russell A., 50

Van Houdt, J., 704

van Lier, R. B. L., 551Van Loon, Jon A., 632Van Veldhuizen, A., 999

Van Vunakis, Helen, 508Vasquez, Maria T., 753

Verbeeck, R., 267Vergin, H., 962Veronese, Maurice E., 356

Vickers,S., 138,476

Viney, Nicholas J., 613Vree, T. B., 954Vree,TomB., 852

Vyas, Kamlesh P., 203, 218, 1025

Vyas, K. P., 476

Waddell, William J., 276, 504

Walker, David G., 613Walle,T., 1

Walle,U.K., 1Walsh, John, 1078Walsh, John S., 1084, 1092Warner, R., 429Watanabe, Kazuhito, 943Watanabe, Yoshifumi, 698Waterhous, D. Vincent, 369Webb, Andrew J., 613

Wei, Robert, 488Weierstall, R., 429Weil,Andre, 115

Weinshilboum, Richard M., 632Wells, D. S., 746Whiterock, Valerie J., 153

Whitfield, Lloyd R., 980Wijnands, W. J. A., 954Williams, David E., 418Wilson, Alan G., 373Wolff,T., 1005Wong, Bradley K., 980

Wong, F. A., 949, 1103WOOd,J. M., 831Wood, Phillipa J., 613

Woodcroft, Kimberly J, 1031Wooldndge, C. B., 435

Woolf, Thomas F., 980

Wratten, Stephen J., 373

Wright, Michel, 895

Yamamoto, Ikuo, 943Yamamoto, Toshinori, 276Yamano, Shigeru, 462

Yatscoff, Randall, 226Yee, Gary C., 68Yeh, S. Y., 453Yeung, Pollen K. F., 1055Yodis, L. P., 607Yokogawa, Koichi, 258York, B., 435

Yoshihara, Shin’ichi, 876Yoshikawa, M., 212Yoshimura, Hidetoshi, 943Yoshizumi, Hideo, 565Yu, Hsiu-Ying, 121

Zemaitis, Michael A., 888Zhang, Kanyin, 794Ziv, Ehud, 238

1111

SUBJECT INDEX

Acetaldehyde, inhibition ofethyl carbamate metabolism (humans, mice),

504

Acetaminophenbiliary and urinary excretion of metabolites, effect, microsomal en-

zyme inducers (rats), 10

detoxification, glutathione, life span profiles (mice), 882metabolism and cytotoxicity, hepatocyte cultures (rats, rabbits, dogs,

monkeys), 659

metabolite profiles, hepatic protein arylation (mice), 765vancomycin and antipyrine, pharmaceutics (swine), 387

Acetone, induction of cytochrome P-450 isozyme 3a, olfactory mucosa

(rabbits), 742N-Acetyl-S42,S-dihydroxyphenyl)-L-cysteine, urinary metabolite, ben-

zene, phenol and hydroquinone (rats), 958a-l-Acid glycoprotein, interleukin 113 and TNF-a, liver cytochrome P-

450 (rats), 467Acquired immunodeficiency syndrome, anti-AIDS drug 2’,3’-dideoxyi-

nosine, pharmacokinetics (rats), 654Adipose tissue, amiodarone disposition, desethylamiodarone, single-dose

and short-term drug regimens (dogs), 846

Adrenal cortex, inner and outer zones, carbon tetrachloride administra-tion, cytochrome P-450 and antioxidant levels (guinea pigs), 543

Aging

-associated alterations in diazepam, metabolizing enzyme activities

(rats), 812dose and, disposition and metabolism, salicyclic acid (rats), 494life span profiles, glutathione and acetaminophen detoxification

(mice), 882

-related distribution kinetics ofbiperiden, fat tissue volume (rats), 258

Alachior, metabolism by liver and nasal turbinate tissues (rats, mice),373

Alanine aminotransferase, metabolism and cytotoxicity, acetaminophen,hepatocyte cultures (rats, rabbits, dogs, monkeys), 659

Aiclometasone dipropionate, metabolic fate (rats, rabbits, mice), 409Aldehyde, ajI-unsaturated, metabolism of citral (rats), 866

Aldehyde oxidase, diphenyl sulfoxide metabolism in liver (guinea pigs),

876Aldose reductase, inhibitors, interspecies comparison (rats, dogs, mon-

keys, chimpanzees, humans), 435N-Alkyl amines, Best Paper Award, 823Alveolar type II cells, morphologic changes and covalent binding, 1,1-

dichloroethylene, lungs (mice), 534Amides, unsubstituted, potent inhibitors, microsomal epoxide hydrolase

(humans), 540

1-Aminobenzotriazolemetabolism and pharmacologic activity, flurazepam (mice), 190

three N-aralkylated derivatives, inhibition of pulmonary cytochromeP-450 (guinea pigs), 1031

Aminoboronic acid, derivative, inhibition of leucine enkephalin metab-olism, blood, plasma and tissues (rats), 288

Aminopyrine, formation and metabolism, N-nitroso-dimethylnitrosa-mine (pigs), 626

Amiodarone, disposition, single-dose and short-term drug regimens

(dogs), 846

Analgesic, opioid, racemic picenadol disposition (humans), 968Antiarrhythmic drugs

pharmacokinetics of disopyramide (dogs), 42recainam, excretion and metabolism (mice, rats, dogs, monkeys, hu-

mans), 746urinary metabolites of encainamide, structural characterization, 28

Anticonvulsant agents, zonisamide metabolism (rats), 888Antidepressants, tianeptine, metabolic pathways (humans), 804Anti-inflammatory agents, flobufen and its main active metabolite, phar-

macokinetics (rats), 1060

Antiischemic agents, LY256548 pharmacokinetics (rats, mice, dogs,monkeys), 674

Antipyrine, acetaminophen and vancomycin, pharmaceutics(swine), 387

Arylamine N-acetyltransferase, acetylator genotype-dependent expres-

sion, intestine and colon (hamsters), 680

2-Arylpropionic acids, glucuronidation by liver microsomes (rats, mice),

692

Aspartame, activity ofliver xenobiotic-metabolizing enzymes (rats), 223

3 ‘-Azido-3 ‘-deoxythymidine, glucuronidation, liver microsomes (rats,

humans), 369

Benz[a]anthracene, bioalkylation as biochemical probe, carcinogenic

activity (rats), 163Benzene

metabolism and covalent binding, liver (mice, rats, humans), 20

metabolism in hepatocytes (rats), 720

urinary metabolite N-acetyl-S-(2,S-dihydroxyphenyl)-L-cysteine (rats),958

Benzoic acid, disposition (channel catfish), 552

S-(2-Benzothiazolyl)-L-cysteine, metabolites as markers, cysteine conju-gate �i-lyase, thiol glucuronosyl transferase activities (rats, ham-

sters, guinea pigs), 917�

me, pharmacokinetics and tissue distribution (marmosets), 831

Bernard B. Brodie Award, functional diversity, hepatic cytochrome P-

450, 824

Bile

enterohepatic circulation model, reversible clearance, drug and con-

jugate metabolite pair, 80phenolic doxepin glucuronide (humans, rats), 1096

production, indomethacin elimination kinetics, sodium salicylate ef-

fects (dogs), 962taxol metabolism (rats), 895

Biperiden, age-related distribution kinetics, fat tissue volume (rats), 258

Blood, inhibition ofleucine enkephalin metabolism, aminoboronic acidderivative (rats), 288

Blood flowhepatic

formation of metabolites, 270

sequential infusions, indocyanine green or galactose (rats), 197rate, physiological pharmacokinetics, inaperisone, 902

Bone marrow, 3-methylcholanthrene metabolism (humans), 664Bromobenzene, metabolism (rats), 304

Caffeinecytochrome P-450-dependent metabolism, inhibition by quinoline,

liver microsomes (humans), 1005metabolism, growth hormone effect, hypophysectomized rats, 327

Cannabichromene, metabolism (mice, rats, guinea pigs, rabbits, ham-

sters, gerbils, cats), 1065

Cannabidiol1 ‘ ‘ ‘-dimethylheptyl analogue, microsomal metabolism (mice, rats,

guinea pigs, rabbits), 548urinary metabolites (dogs), 571

Cannabinoid analog, cis-3-[2-hydroxy-4-( 1, l-dimethylheptyl)phenyl]-trans-4 -(3-hydroxypropyl)cyclohexanol metabolism (mice), 1046

Cannabinoids, oxidative cleavage of pentyl side-chain (mouse), 350Carbonic anhydrase, inhibitor MK-4l7, dose-dependent pharmacoki-

netics (rabbits), 836Carbon tetrachloride, cytochrome P-450 and antioxidant levels, inner

and outer zones, adrenal cortex (guinea pigs), 543

Carbovirdisposition and metabolism (mice), 842

SUBJECT INDEX

phenolic glucuronides, urine and bile (humans, rats), 1096

urinary metabolites (humans), 735

glucuronide conjugate, urine (marmosets), 1092

metabolism and excretion (rats), 1084

pharmacokinetics (rats), 1078

Carcinogenesis, biochemical probe for carcinogenic activity, bioalkyla-

tion, benz[a]anthracene (rats), 163Cecum, microflora, enzymatic reduction, epoxysuccinic acid derivative

(rats), 264Cefazolin, diposition and renal handling, diabetes effect (rats), 565

CGP 38 560, pharmacokinetics and tissue distribution (marmosets), 831

2-Chloro-l,l-difluoroethene, metabolism to glyoxylic acid and glycolic

acid, hepatic microsomes (rats), 753Chlorofluoroacetamides, selective inactivation, phenobarbital-inducible

forms, liver cytochrome P-450 (rats), 168

Chloronitrobenzenes, metabolism in hepatocytes (rats), 5Chlorotrianisene, formation of reactive intermediate, role of P-450c,

hepatic microsomes (rats), 131

Cholesterol, -lowering prodrug, simvastatin, metabolic disposition (rats,

rabbits, mice, dogs), 138

Chromatography, high-performance liquid, DP-l904 and its ester glu-

curonide, urine (humans), 698Cimetidine, etintidine metabolism (rats, dogs, humans), 949

Ciprofloxacin, elimination ofdiazepam (humans), 954

Citral, metabolism (rats), 866

Clara cells, morphologic changes and covalent binding, l,l-dichloroeth-ylene, lungs (mice), 534

Clarithromycin, metabolism and disposition (humans), 441Codeine, pharmacokinetics, parenteral and oral dosing (rats), 670Colon, acetylator genotype-dependent expression, arylamine N-acetyl-

transferase, N-hydroxyarylamine O-acetyltransferase (hamsters),

680

Cotinineinteraction with hepatic microsomal P-450 (rats), 759radioimmunoassay, nicotine ion (rabbits), 508

2-Cyano-l-methyl 3-(4-(4-methyl-6-oxo-l,4,5,6-tetrahydropyridazin-3-yl)phenyl)guan idine, disposition (rats, dogs, mice), 613

Cyclosporin A

drug interactions (humans), 595novel human metabolite, 68prednisolone clearance in perfused liver, normal and uremic rats, 231

Cyclosporine

bioavailability assessment (rats), 158

disposition in pregnancy (rabbits), 102metabolite M-l 7, pharmacokinetics and biotransformation (rabbits),

226

Cysteineconjugate fl-lyase, purification, characterization (humans), 50conjugate fl-lyase and thiol glucuronosyl transferase, S-(2-benzothia-

zolyl)-L-cysteine metabolites (rats, hamsters, guinea pigs), 917

Cytochrome P-450antioxidant levels and, carbon tetrachloride administration, adrenal

cortex (guinea pigs), 543

Best Paper Award, 823biotransformation of lovastatin (humans), 218-catalyzed hydroxylation, N-nitrosodibutylamine (rats, guinea pigs,

hamsters), 398

cyclosporin A drug interactions (humans), 595

-dependent caffeine metabolism, inhibition by quinoline, liver micro-

somes (humans), 1005

flavin-containing monooxygenase, (.5)-nicotine metabolism, lung (rab-bits), 418

hepatic

functional diversity, 824vanadate, streptozotocin-diabetic rats, 519

IIA 1 and 11A2, cDNA-directed expression (rats), 378

induction of isozyme 3a, olfactory mucosa, ethanol and acetone (rab-bits), 742

interleukin lfi and TNF-a, serum a-I-acid glycoprotein concentrations

(rats), 467

isozymes, metabolic activation of tetrahydrocannabinol, liver micro-somes (rats), 943

isozymes that metabolize naphthalene, liver and lung (mice), 557major phenobarbital-inducible forms, selective inactivation, chloro-

fluoroacetamides (rats), 168

metabolic fate of stiripentol (rats), 794

progesterone metabolism in hepatic microsomes (humans, monkeys,

dogs, rats), 859pulmonary, three N-aralkylated derivatives, l-aminobenzotriazole

(guinea pigs), 1031

purified forms, tolbutamide hydroxylation, liver microsomes (humans,

rabbits, rats), 356

specificity and potency of inducers, 7-ethoxyresorufin, 551

suicide inactivator l-aminobenzotriazole, metabolism and pharmaco-logic activity, fluazepam (mice), 190

Cytochrome P-450c, formation of reactive intermediate, chlorotriani-sene, hepatic microsomes (rats), I 31

Cytochrome P-450h, pretranslational suppression of gene expression,interferon inducers (rats), 649

Cytochrome P-4SOIIA1, -catalyzed formation of �6-testosterone, fromtestosterone, isotope effect studies, 974

Cytochromes P-4SOIIIA, N-demethylation of diltiazem (rabbits, hu-

mans), 7 1 1

Desethylamiodarone, amiodarone disposition, single-dose and short-term drug regimens (dogs), 846

Deuterium, isotope effect, toxicokinetics, monomethylamine (rats), 447Diabetes

disposition and renal handling ofcefazolin (rats), 565

streptozotocin, vanadate, hepatic cytochrome P-450 expression (rats),

�19

Diazepam

age-associated alterations, metabolizing enzyme activities (rats), 812elimination, ciprofloxacin (humans), 954

l,l-Dichloro-cis-diphenylcyclopropane, metabolism by liver microsomes

(rats), 7711, l-Dichloroethylene, morphologic changes and covalent binding, Clara

and alveolar type II cells, lungs (mice), 534

2’,3’-Didehydro-3’-deoxythymidine, disposition (rats, monkeys, dogs),

153

2’,3’-Dideoxyinosine, pharmacokinetics (rats), 654

Diflunisal

disposition (mice), 937

elimination kinetics, role of sulfate conjugation (rats), 267, 268

Dihydro-CsA MI7, novel human metabolite, cyclosporine A, 68

Diltiazem

N-demethylation, cytochromes P-450111A (rabbits, humans), 71 1

parent drug biotransformation, metabolite inhibition (rats), 180

pharmacokinetics and metabolism (humans, dogs, rabbits, rats), 10553,7-Dimethyl-2,6-octadienal, metabolism (rats), 866

Dimethylaminoazobenzene, azoreduction, hepatocytes (rats), 36

1 ‘ ‘,1 ‘ ‘-Dimethylheptyl analogue, cannabidiol, microsomal metabolism(mice, rats, guinea pigs, rabbits), 548

Diphenyl sulfoxide, metabolism in liver (guinea pigs), 876Disopyramide, pharmacokinetics (dogs), 42

DNA, complementary, -directed expression, P450s hAl and 11A2 (rats),

378L-Dopa, absorption of novel prodrug (rats), 621

Dopamine

agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin, metab-

olism and disposition (monkeys), 923prodrug N-(N-acetyl-L-methionyl)-O,O-bis (ethoxycarbonyl) dope-

mine (humans), 212Dopazinol, metabolism by liver microsomes (rats), 1025Doxepine

SUBJECT INDEX 1113

isomeric naphthalene oxide conjugates, metabolism (mice), 183

DP-1904, ester glucuronide in urine, enantiomeric compositions (hu-

mans), 698

Encainide, urinary metabolites, structural characterization, 28Epoxide hydrolase, microsomal, potent inhibitors, unsubstituted amides

(humans), 540Epoxysuccinic acid, derivative, enzymatic reduction, cecal microflora

(rats), 264

Ethanol

induction ofcytochrome P-450 isozyme 3a, olfactory mucosa (rabbits),742

nitrendipine and, pharmacokinetic interaction, hypothermia (rats),127

single dose, kinetics of valproic acid (rats), 732Ether glucuronide, zidovudine, major metabolite (monkeys, humans),

321Ethmizol

disposition in liver and hepatocytes, 88enzyme induction and inhibition on disposition, 96

xanthine-related, hepatic extraction ratio, 3837-Ethoxyresorufin, specificity and potency, cytochrome P-450 inducers,

�

Ethyl carbamateinhibition of metabolism by acetaldehyde (humans, mice), 504metabolism (mice), 276

Etintidine, metabolism (rats, dogs, humans), 949Etodolac, enantiomers, pharmacokinetics (rats), 471

Fat, tissue volume, age-related distribution kinetics, biperiden (rats), 258Fenofibrate, metabolism and disposition (humans), 1 15Flavin, -containing monooxygenase, cytochrome P-450, (5)-nicotine me-

tabolism in lung (rabbits), 418

Flobufen, main active metabolite, pharmacokinetics (rats), 10605-Fluoro-2’-deoxyuridine, pulmonary elimination and metabolism, lung

and lung slices (rats), 10116-(4’-fluorophenyl)-S-(4’-pyridyl)-2,3-dihydroimidazo�2,I-6}-thiazole,

metabolism of novel antiinflammatory agent (rats), 607

Flurazepam, metabolism and pharmacologic activity, effect of 1-aminob-enzotriazole (mice), 190

Flurbiprofen, glucuronidation by liver microsomes (rats, mice), 692Fosinophil sodium, first-pass hydrolysis, relative contribution of gut,

liver and lung (dogs), 253

Galactose, determination of hepatic blood flow, sequential infusions(rats), 197

Gallopamil, pathways of metabolism, 309, 331Genes, cytochrome P-450h, pretranslational suppression, interferon in-

ducers (rats), 649Gentisamide

first-pass metabolismestimations, intestine and liver (rats), 588hepatic formation of conjugates (rats), 580

Glucuronidation3’-azido-3’-deoxythymidine, liver microsomes (rats, humans), 369role of sulfate conjugation, elimination kinetics, diflunisal (rats), 267,

268

Glucuronideconjugate, carbovir, urine (marmosets), 1092phenolic doxepin, urine and bile (humans, rats), 1096

Glutathioneacetaminophen detoxification and, life span profiles (mice), 882conjugate formation in kidney, hexafluoropropene metabolism (rats),

911hepatic protein arylation, metabolite profiles, acetaminophen (mice),

765

Glutathione S-transferase, nitroglycerin metabolism, subcellular frac-

tions, liver (rabbits), 292Glyoxylic acid, glycolic acid and, metabolism of 2-chloro-l,l-difluoroeth-

ene, hepatic microsomes (rats), 753Growth hormone, caffeine metabolism, hypophysectomized rats, 327Gut, first-pass hydrolysis, fosinophil sodium (dogs), 253

Halothane

biotransformation in liver slices (guinea pigs), 514factors affecting expression, trifluoroacetylated liver microsomal pro-

tein neoantigens (rats), 788metabolism and hepatotoxicity, 819

Hepatocytesazoreduction of dimethylaminoazobenzene (rats), 36benzene metabolism (rats), 720biotransformation of fl-nortestosterone (pigs), 999

cultures, metabolism and cytotoxicity, acetaminophen (rats, rabbits,dogs, monkeys), 659

cyclosporin A drug interactions (humans), 595disposition ofethmizol, 88

distribution and disposition, trospectomycin sulfate (rats), 726enzyme induction and inhibition, ethmizol disposition, 96

metabolism and chiral inversion of ibuprofen (rats), 527metabolism of chloronitrobenzenes (rats), 5metabolism of temelastine (rats, dogs, monkeys, humans), 146

Hepatotoxicity, metabolism and covalent binding to benzene, liver (mice,

rats, humans), 20Hexafluoropropene, metabolism (rats), 911Human immunodeficiency virus, disposition of 2’,3’-didehydro-3’-

deoxythymidine (rats, monkeys, dogs), 153

Hydrogen, cytochrome P-4SOIIA 1-catalyzed formation, �-testosteronefrom testosterone, isotope effect studies, 974

Hydroquinone, urinary metabolite N-acetyl-S-(2,S-dihydroxyphenyl)-L-

cysteine (rats), 958cis-3-[2-Hydroxy-4-( 1 , 1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypro-

pyl) cyclohexanol, metabolism (mice), 10463’-Hydroxyacetanilide, hepatic protein arylation, metabolite profiles,

acetaminophen (mice), 765N-Hydroxyarylamine O-acetyltransferase, acetylator genotype-depend-

ent expression, intestine and colon (hamsters), 680

4’-Hydroxy-delta-9-tetrahydrocannabinol, oxidative cleavage of pentylside-chain (mouse), 350

Hydroxylamine, hepatic microsomal metabolism, sulfamethoxazole

(mice), 7843-Hydroxy-3-methylglutaryl-C0A, biotransformation of simvastatin

(rats, dogs), 4761Sa-Hydroxy-norandrostenedione, biotransformation of /3-nortestoster-

one, use of hepatocytes (pigs), 999N-(4-Hydroxyphenyl)-all-trans-retinamide, distribution and metabolism

of metabolite, N-(4-methoxyphenyl)-all-trans-retinamide (mice),175

L-3-(3-Hydroxy-4-pivaloylOxyphenyl)alanine, absorption of novel pro-drug of L-dopa (rats), 621

4-Hydroxypropranolol, pharmacokinetics and metabolism (dogs), 14-Hydroxypyrazole, pyrazole and, interaction, liver microsomes (rats),

393

Hydroxytoluene, butylated, pharmacokinetics of LY256548 (rats, mice,dogs, monkeys), 674

Hypolipidemic agents, azoreduction of dimethylaminoazobenzene, he-

patocytes (rats), 36Hypophysectomy, effect ofgrowth hormone, caffeine metabolism, 327Hypothermia, pharmacokinetic interaction, ethanol and nitrendipine

(rats), 127

Ibuprofenglucuronidation by liver microsomes (rats, mice), 692metabolism and chiral inversion, hepatocytes (rats), 527

1114 SUBJECT INDEX

ICRF-187, hydrolysis activation, 344

Imidazole, quaternary N-glucuronide metabolite, tioconazole, I 100Inaperisone, physiological pharmacokinetics, blood flow rate, 902

Indocyanine green, determination of hepatic blood flow, sequential

infusions (rats), 197Indomethacin, elimination kinetics, bile production, sodium salicylate

effects (dogs), 962

Inotropes, disposition of SK&F 94836 (rats, dogs, mice), 613Interferon, inducers, pretranslational suppression, cytochrome P-450h

gene expression (rats), 649Interleukin 1/3, tumor necrosis factor-a and, liver cytochrome P-450,

serum cr-I-acid glycoprotein concentrations (rats), 467

Intestineacetylator genotype-dependent expression, arylamine N-acetyltransfer-

ase, N-hydroxyarylamine O-acetyltransferase (hamsters), 680enterohepatic circulation model, reversible clearance, drug and con-

jugate metabolite pair, 80estimations of first-pass metabolism, gentisamide (rats), 588

hepatic formation of conjugates, gentisamide, first-pass metabolism(rats), 580

Ischemia, antiischemic agent LY256548, pharmacokinetics (rats, mice,

dogs, monkeys), 674

Isoniazid, halothane metabolism and hepatotoxicity, 819Isosorbidedintrate, isosorbide-2-mononitrate and isosorbide-S-mononi-

trate, pharmacokinetic model (humans), 429

Ketoconazole, progesterone metabolism in hepatic microsomes (humans,

monkeys, dogs, rats), 859

Kidney

cysteine conjugate /3-lyase (humans), 50

glutathione conjugate formation, hexafluoropropene metabolism

(rats), 9 1 1handling and disposition ofcefazolin, diabetes effect (rats), 565

thiopurine methyltransferase isozymes (humans), 632

Leucine enkephalin, metabolism in blood, plasma and tissues, inhibition,aminoboronic acid derivative (rats), 288

Liver

acetylator genotype-dependent expression, arylamine N-acetyltransfer-

ase, N-hydroxyarylamine O-acetyltransferase (hamsters), 680

alachlor metabolism (rats, mice), 373

blood flow, formation of metabolites, 270

cytochrome P450interleukin 1/3 and TNF-a, serum a-l-acid glycoprotein concentra-

tions (rats), 467vanadate, streptozotocin-diabetic rats, 519

cytochrome P450 isozymes, naphthalene metabolism (mice), 557diphenyl sulfoxide metabolism (guinea pigs), 876disposition ofethmizol, 88

distribution and disposition, trospectomycin sulfate (rats), 726

enterohepatic circulation model, reversible clearance, drug and con-jugate metabolite pair, 80

enzyme induction and inhibition, ethmizol disposition, 96estimations of first-pass metabolism, gentisamide (rats), 588

first-pass hydrolysis, fosinophil sodium (dogs), 253

hepatic blood flow, sequential infusions, indocyanine green or galac-

tose(rats), 197

hepatic extraction ratio, xanthine-related nootropic drug ethmizol, 383

hepatic formation of conjugates, gentisamide, first-pass metabolism

(rats), 580major phenobarbital-inducible forms of cytochrome P450, selective

inactivation, chlorofluoroacetamides (rats), 168-mediated reduction of naloxone, morphine, stimulation (guinea pigs),

462metabolism and covalent binding ofbenzene (mice, rats, humans), 20

mexiletine metabolism (humans), 362

perfused

disposition of valpromide (rats), 238prednisolone clearance, normal and uremic rats, 231

protein arylation, metabolite profiles, acetaminophen (mice), 765slices, halothane biotransformation (guinea pigs), 514subcellular fractions, nitroglycerin metabolism (rabbits), 292xenobiotic-metabolizing enzymes, aspartame effect on activity (rats),

223

Liver microsomes

biotransformation oflovastatin (humans), 218biotransformation of sufentanil (rats, dogs, humans), 704cyclosporin A drug interactions (humans), 595l,1-dichloro-cis-diphenylcyclopropane (rats), 771

dopazinol metabolism (rats), 1025glucuronidation of 3’-azido-3’-deoxythymidine (rats, humans), 369glucuronidation of 2-arylpropionic acids (rats, mice), 692hepatic cytochrome P450, functional diversity, 824inhibition by quinoline, cytochrome P450-dependent caffeine metab-

olism (humans), 1005interaction, pyrazole and 4-hydroxypyrazole (rats), 393

metabolic activation of tetrahydrocannabinol, cytochrome P450 iso-

zymes (rats), 943

metabolism of 1 ‘ ‘ ‘-dimethylheptyl analogue, cannabidiol (mice,

rats, guinea pigs, rabbits), 548metabolism of 2-chloro-l,1-difluoroethene, glyoxylic and glycolic acid

(rats), 753

oxidative defluorination, l,1,l,2-tetrafluoroethane (rats), 992progesterone metabolism (humans, monkeys, dogs, rats), 859role of P-450C, reactive intermediate, chlorotrianisene (rats), 131

sulfamethoxazole metabolism, hydroxylamine (mice), 784tolbutamide hydroxylation, purified forms, cytochrome P450 (hu-

mans, rabbits, rats), 356toluene metabolism and covalent binding (humans, rats), 929trifluoroacetylated neoantigens, halothane treatment (rats), 788

Lovastatin, biotransformation (rats, mice), 203, 218

LungClara and alveolar type II cells, morphologic changes and covalent

binding, l,l-dichloroethylene (mice), 534cytochrome P450 isozymes, naphthalene metabolism (mice), 557

elimination and metabolism, S-fluoro-2’-deoxyuridine (rats), 1011first-pass hydrolysis, fosinophil sodium (dogs), 253inhibition of cytochrome P450, three N-aralkylated derivatives, 1-

aminobenzotriazole (guinea pigs), 1031(5)-nicotine metabolism, cytochrome P450, flavin-containing mon-

ooxygenase (rabbits), 418LY256548, pharmacokinetics (rats, mice, dogs, monkeys), 674/3-Lyase

cysteine conjugate, purification, characterization (humans), 50thiol glucuronosyl transferase activities and, S-(2-benzothiazolyl)-L-

cysteine metabolites (rats, hamsters, guinea pigs), 917

M-l7, cyclosporine metabolite, pharmacokinetics and biotransformation

(rabbits), 2264-MA, progesterone metabolism in hepatic microsomes (humans, mon-

keys, dogs, rats), 859

Methapyrilene, plasma elimination and urinary excretion (rats), 1018

N-(4-Methoxyphenyl)-all-trans-retinamide, distribution and metabolism(mice), 175

8-Methoxypsoralen, inhibition of induction of theophylline metabolism

(rats, humans), 298N-(l-Methyl-3,3-diphenylpropyl)isocyanate, formation and reversibility

ofS-linked conjugates (rats), 1038Methylcholanthrene, role of P-450c in formation of reactive intermedi-

ate, chlorotrianisene, hepatic microsomes (rats), 1313-Methylcholanthrene, metabolism in bone marrow (humans), 6643,4-Methylenedioxymethamphetamine, stereochemical differences in

metabolism (rats), 686

SUBJECT INDEX 1115

Methylphosphonate, disposition and metabolism (mice), 815

Methysergide, pharmacokinetics, metabolite methylergometrine (rats),

338

Metyrapone, interaction of cotinine with hepatic microsomal P450(rats), 759

Mexiletine, metabolism by liver (humans), 362Microflora, cecal, enzymatic reduction, epoxysuccinic acid derivative

(rats), 264Microsomal enzyme inducers, biliary and urinary excretion, acetamino-

phen metabolites (rats), 10Microsomes, skin, metabolic fate, l3-cis-retinoic acid (mice), 1 105MK-4l7, dose-dependent pharmacokinetics (rabbits), 836

MK-571plasma protein binding, species dependence(baboons, monkeys, cattle,

sheep, cats, rabbits, guinea pigs, mice, dogs, rats, humans), 484stereoselective protein binding and clearance, interspecies differences

(rats, dogs), 388Monoclonal antibodies, anti-cotinine, immunomodulation of cotinine,

metyrapone comparison (rats), 759

Monomethylamine, toxicokinetics, deuterium isotope effect (rats), 447Monooxygenase, flavin-containin& cytochrome P450, (5)-nicotine me-

tabolism in lung (rabbits), 418Morphine, stimulation mechanism, liver-mediated reduction, naloxone

(guinea pigs), 462Muscle relaxants, inaperisone, physiological pharmacokinetics, blood

flow rate, 902

NADPH 5a-reductase, inhibitor, progesterone metabolism, hepatic mi-

crosomes (humans, monkeys, dogs, rats), 859Naloxone, liver-mediated reduction, stimulation mechanism, morphine

(guinea pigs), 462Naphthalene, metabolism, cytochrome P450 isozymes, liver and liver

(mice), 557

Naphthalene oxide, glutathione conjugates, metabolism (mice), 183fi-Naphthoflavone, halothane metabolism and hepatotoxicity, 819

NB-355, absorption of novel prodrug (rats), 621Neoantigens, trifluoroacetylated liver microsomal protein, factors affect-

ing expression, halothane (rats), 788

Nephrotoxicity, kidney cysteine conjugate /3-lyase (humans), 50(3)-Nicotine, metabolism in lung, cytochrome P450, flavin-containing

monooxygenase (rabbits), 418

Nicotine ion, radioimmunoassay (rabbits), 508Nitrendipine, ethanol and, pharmacokinetic interaction, hypothermia

(rats), 127

Nitroglycerindegradation, thiol-mediated catalysis, serum proteins (humans), 61metabolism in subcellular fractions, liver (rabbits), 292

N-Nitrosodibutylamine, P450-catalyzed hydroxylation(rats, guinea pigs,

hamsters), 398N-Nitroso-dimethylnitrosamine, formation and metabolism (pigs), 626

/3-Nortestosterone, biotransformation, use of hepatocytes (pigs), 999Nucleosides

carbocyclic, metabolism and excretion, carbovir (rats), 1084

glucuronide conjugate, urine (marmosets), 1092

Ofloxacin, metabolism (humans), 1103

Olfactory mucosa, induction ofcytoch.rome P450 isozyme, ethanol andacetone (rabbits), 742

Oligodeoxynucleoside methylphosphonate, disposition and metabolism(mice), 815

Penem, SUN5555, physiologically based pharmacokinetics (rats), 245

Phencyclidine, Best Paper Award, 823Phenobarbital

halothane metabolism and hepatotoxicity, 819

-inducible forms of liver cytochrome P450, selective inactivation,

chlorofluoroacetamides (rats), 168

Phenol

glucuronidation, benzene metabolism, hepatocytes (rats), 720urinary metabolite N-acetyl-S-(2,5-dihydroxyphenyl)-L-cysteine (rats),

958

Phenytoin

disposition in pregnancy (rats), 72halothane metabolism and hepatotoxicity, 819

Picenadol, racemic, dispostion (humans), 968Pirprofen, glucuronidation by liver microsomes (rats, mice), 692Plasma

elimination, urinary excretion, methapyrilene (rats), 1018inhibition of leucine enkephalin metabolism, aminoboronic acid de-

rivative (rats), 288protein binding of MK-571, species dependence (baboons, monkeys,

cattle, sheep, cats, rabbits, guinea pigs, mice, dogs, rats, humans),484

Prednisolone

clearance in perfused liver, normal and uremic rats, 231interconversion and disposition, thyroid dysfunction (rats), 403

steroid-21-oate ester derivatives, pharmacokinetics (rats), 55

Pregnancy

cyclosporine disposition (rabbits), 102phenytoin disposition (rats), 72

Pregnenolone 16-a carbonitrile, halothane metabolism and hepatotoxic-

ity, 819

Progesterone, metabolism in hepatic microsomes (humans, monkeys,

dogs, rats), 859Propafenone, enantiomers, pharmacokinetics (rats), 987Propranolol, pharmacologically active 4’-hydroxylated metabolite (dogs),

24N-Propyl-N-2-thienylethylamino)-S-hydroxytetralin, metabolism and

disposition (monkeys), 923Prostaglandin F2, metabolism (sheep), 107

Protein

binding, pharmacokinetics, salicylate metabolites (rats), 809binding and clearance, MK-571, interspecies differences (rats, dogs),

388

serum, thiol-mediated catalysis, nitroglycerin (humans), 61Proteins, covalent binding of zomepirac glucuronide, Schiff base mech-

anism, 639Pyrazole, 4-hydroxypyrazole and, interaction, liver microsomes (rats),

393

Pyrilamine, N-depyridination and N-dedimethylaminoethylation, tripe-

lennamine (rats), 453

Quinoline, inhibition by cytochrome P450-dependent caffeine metabo-lism, liver microsomes (humans), 1005

Radioimmunoassay, nicotine ion (rabbits), 508

Recainam, excretion and metabolism (mice, rats, dogs, monkeys, hu-mans), 746

Receptors, histamine H2, etintidine metabolism (rats, dogs, humans),949

13-cis-Retinoic acid, metabolic fate, skin microsomal preparations

(mice), 1 105

Retinoids, acetylenic, systemic pharmacokinetics (rats), 1071Rimantadine, unusual glucuronide conjugate, 546Ritodrine, conjugated metabolites, structural determination, 488

Salicyclic acid, disposition and metabolism, age and dose effects (rats),494

Salicylatemetabolites, pharmacokinetics, protein binding (rats), 809pharmacokinetics of valproic acid (rats), 121phenytoin disposition in pregnancy (rats), 72

Schiffbase, covalent binding of zomepirac glucuronide, proteins, 639

1116 SUBJECT INDEX

Serum, proteins, thiol-mediated catalysis, nitroglycerin (humans), 61

Simvastatinbiotransformation (rats, dogs), 476metabolic disposition studies (rats, rabbits, mice, dogs), 138

SK&F 86002, metabolism of novel antiinflammatory agent (rats), 607SK&F 93944, metabolism in hepatocytes (rats, dogs, monkeys, humans),

146SK&F 94836, disposition (rats, dogs, mice), 613Skin, microsomal preparations, metabolic fate, 13-cis-retinoic acid

(mice), 1 105Sodium salicylate, elimination kinetics ofindomethacin, bile production

(dogs), 962Steroid-2l-oate ester derivatives, prednisolone, pharmacokinetics (rats),

55Steroids, cDNA-directed expression, P450S hA 1 and 11A2 (rats), 378

Stiripentol, metabolic fate (rats), 794Stomach, diflunisal disposition (mice), 937

Streptozotocin, -diabetic rats, vanadate, hepatic cytochrome P450expression, 519

Sufentanil, biotransformation in liver microsomes (rats, dogs, humans),

704Sulfa-6-monomethoxine, pharmacokinetics, N1-glucuronidation, N4-ace-

tylation (humans), 852

SUN5555, physiologically based pharmacokinetics (rats), 245

TA-87O, disposition (humans), 212Tacrine, urinary metabolites (rats), 779

Tamoxifen, acidic metabolites, identification and distribution (rats), 645Taxol, metabolism (rats), 895Temelastine, metabolism in hepatocytes (rats, dogs, monkeys, humans),

146Terpenes, metabolism ofcitral (rats), 866i�6-Testosterone, from testosterone, cytochrome P-45011A 1-catalyzed for-

mation, isotope effect studies, 974I, 1, 1,2-Tetrafluoroethane, oxidative defluorination, liver microsomes

(rats), 992Tetrahydrocannabinol, metabolic activation, cytochrome P450 iso-

zymes (rats), 943Theophylline, inhibition and induction of metabolism, 8-methoxypso-

mIen (rats, humans), 298

Thiazolidinone, pharmacokinetics of LY256548 (rats, mice, dogs, mon-keys), 674

Thiol, -mediated catalysis, nitroglycerin degradation, serum proteins(humans), 61

Thiol glucuronosyl transferase, /3-lyase and, S-(2-benzothiazolyl)-L-cys-teine metabolites (rats, hamsters, guinea pigs), 917

Thiopunne methyltransferase, isozymes, renal tissue (humans), 632Thyroid, dysfunction, prednisolone, interconversion and disposition

(rats), 403Tianeptine, metabolic pathways, new antidepressant (humans), 804Tioconazole, quaternary N-glucuronide metabolite, 1100Tolbutamide, hydroxylation by liver microsomes, purified forms, cyto-

chrome P450 (humans, rabbits, rats), 356Toluene, metabolism and covalent binding, liver microsomal fractions,

liver slices (humans, rats), 929

Trimetrexate, metabolic disposition (rats, dogs), 980Tripelennamine, N-depyridination and N-dedimethylaminoethylation

(rats), 453Trospectomycin sulfate, distribution and disposition, liver and hepato-

cytes(rats), 726Tubinates, nasal, alachlor metabolism (rats, mice), 373Tumor necrosis factor-a, interleukin 1/3 and, liver cytochrome P450,

serum a-l-acid glycoprotein concentrations (rats), 467

Uremia, prednisolone clearance, perfused liver (rats), 231Urine

cannabidiol metabolites (dogs), 571DP-1904 and its ester glucuronide, enantiomeric compositions (hu-

mans), 698excretion, plasma elimination, methapyrilene (rats), 1018glucuronide conjugate, carbovir (marmosets), 1092

metabolites of doxepin (humans), 735phenolic doxepin glucuronide (humans, rats), 1096tacrine metabolites (rats), 779

Valproic acid

kinetics, influence, single dose of ethanol (rats), 732pharmacokinetics, effects of salicylate (rats), 121

Valpromide

disposition, perfused liver (rats), 238unsubstituted amides, potent inhibitors, microsomal epoxide hydrolase

(humans), 540Vanadate, hepatic cytochrome P450 expression, streptozotocin-diabetic

rats, 519

Vancomycin, acetaminophen and antipyrine, pharmaceutics (swine), 387

WR-1065, pharmacokinetics and disposition (monkeys), 281

Xanthine

-related nootropic drug ethmizol

disposition in liver and hepatocytes, 88enzyme induction and inhibition, 96

hepatic extraction ratio, 383Xenobiotic-metabolizing enzymes, liver, aspartame effect on activity

(rats), 223

Xenobiotics, cDNA-directed expression, P450s IIA1 and 11A2 (rats), 378

Zidovudineether glucuronide, major metabolite (monkeys, humans), 321tissue distribution and metabolic disposition (rats), 315

Zomepirac glucuronide, covalent binding to proteins, Schiff base mech-anism, 639

Zonisamide, metabolism (rats), 888